Keytruda immune response trial aims to unlock cancer clues
NCT ID NCT02644369
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing how the immunotherapy drug pembrolizumab (Keytruda) changes immune-related genes and biomarkers in people with advanced solid tumors like head and neck cancer, triple-negative breast cancer, ovarian cancer, and melanoma. Researchers will analyze blood and tumor samples before, during, and after treatment to understand why some patients respond and others do not. The study enrolls 100 adults whose cancer has not responded to standard treatments or for whom no standard therapy exists.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pembrolizumab (Keytruda)
- What this could lead to
- If successful, this could help doctors predict which patients with advanced cancers are most likely to benefit from pembrolizumab, leading to more personalized treatment.
- What could go wrong
- This is an early-phase study focused on understanding immune markers, not on proving the drug works. The results may not change treatment directly, and pembrolizumab can cause immune-related side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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