New cancer combo aims to shrink Hard-to-Treat tumors

NCT ID NCT04626635

Ongoing Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study tests a new drug called marlotamig (REGN7075) alone or with cemiplimab (Libtayo) and sometimes chemotherapy in people with advanced solid tumors. The goal is to find the safest dose and see if the combination can shrink tumors. About 933 participants are being recruited for this early-phase trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: marlotamig (REGN7075) combined with cemiplimab (Libtayo) and sometimes chemotherapy
What this could lead to: If it works, this could offer a new treatment option for people with advanced solid tumors that have stopped responding to other therapies.
What could go wrong: This is an early-phase trial (Phase 1/2), so the main goal is safety and dosing—not yet proof of effectiveness. Side effects from the drug combo could be serious, and many experimental cancer drugs fail in later stages.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS

Contacts and locations

Locations

Baskent Universitesi

Yüreğir, Adana, 01120, Turkey (Türkiye)
Begin Army Instruction Hospital

Saint-Mandé, Île-de-France Region, 94240, France
Centre Antoine Lacassagne

Nice, Provence Alpes Cote dAzur, 06189, France
Centre Georges Francois Leclerc

Dijon, Bourgogne-Franche-Comté, 21034, France
Centre Hospitalier Universitaire (CHU) de Lille

Lille, Hauts-de-France, 59000, France
Centre Hospitalier Universitaire (CHU) de Poitiers

Poitiers, New Aquitaine, 86021, France
Centre Leon Berard (CLB) - Centre de Recherche en Cancerologie Lyon-Est (CRCL)

Lyon, Auvergne-Rhone, 69008, France
Ciftlikkoy Campus Yenisehir Mersin

Mersin, 33343, Turkey (Türkiye)
Dom Lekarski SA

Szczecin, Zach, 70-784, Poland
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi

Ankara, 06200, Turkey (Türkiye)
Erasmus MC

Rotterdam, 3015 GD, Netherlands
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Genesis Care Hospital San Francisco de Asis

Madrid, 28002, Spain
Gustave Roussy

Villejuif, Île-de-France Region, 94800, France
Hadassah Medical Center

Jerusalem, 91220, Israel
Hopital Lyon Sud

Pierre-Bénite, Auvergne-Rhône, 69310, France
Hospital 12 de Octubre

Madrid, 28041, Spain
Hospital Clinico San Carlos

Madrid, 28040, Spain
Hospital Clinico Universitario - University of Valencia

Valencia, 28040, Spain
Hospital General de Catalunya

Sant Cugat del Vallès, Barcelona, 08195, Spain
Hospital Paris Saint-Joseph

Paris, 75014, France
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28040, Spain
Hospital Universitario Quiron Salud Madrid

Pozuelo de Alarcón, Madrid, 28223, Spain
Institut Bergonie

Bordeaux, New Aquitaine, 33076, France
Institut Claudius Regaud, IUCT-Oncopole

Toulouse, Haute-Garonne, 31059, France
Istanbul Medeniyet University - Prof Dr Suleyman Yalcin Sehir Hospital

Istanbul, 81450, Turkey (Türkiye)
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medpolonia Sp. z o.o.

Poznan, Wielkopolska, 60-693, Poland
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Nantes University Hospital

Nantes, Pays de la Loire Region, 44093, France
Netherlands Cancer Institute

Amsterdam, 1066 CX, Netherlands
Rambam Health Care Campus

Haifa, 3109601, Israel
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08901, United States
START Midwest - Cancer & Hematology Centers of Western Michigan, PC

Grand Rapids, Michigan, 49546, United States
Sarah Cannon Research Institute - 25th Ave

Nashville, Tennessee, 37203, United States
Shaare Zedek Medical Center

Jerusalem, 9103102, Israel
Sheba Medical Center

Ramat Gan, Central District, 5265601, Israel
Soroka University Medical Center

Beersheba, 84101, Israel
South Texas Oncology And Hematology

San Antonio, Texas, 78229, United States
Tel Aviv Sourasky Medical Center

Tel Aviv, 64239, Israel
The Regents of the University of California, San Francisco

San Francisco, California, 94118, United States
The Stefanie Spielman Comprehensive Breast Center

Columbus, Ohio, 43212, United States
University of California Los Angeles (UCLA) Medical Center

Los Angeles, California, 90095, United States
University of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States
University of Colorado Hospital - Anschutz Cancer Pavilion - Lung Cancer Clinic

Aurora, Colorado, 80045, United States
University of Florida Health

Gainesville, Florida, 32608, United States
University of Illinois Cancer Center

Chicago, Illinois, 60612, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Washington/Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Valkyrie Clinical Trials

Los Angeles, California, 90067, United States
Vanderbilt Ingram Cancer Center

Nashville, Tennessee, 37232, United States

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