New pill targets rare gene mutations in advanced cancers
NCT ID NCT05265091
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests an experimental drug called KL590586, taken as a capsule, in people with advanced solid tumors that have specific RET gene changes. The trial has two phases: Phase I checks safety and the right dose, while Phase II looks at how well the drug shrinks tumors. Up to 414 participants with cancers like lung or thyroid that have not responded to standard treatments will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- KL590586 capsules
- What this could lead to
- If successful, this could provide a new targeted treatment option for people with advanced solid tumors that have specific RET gene changes.
- What could go wrong
- This is an early-phase trial (Phase I/II) with a small number of participants, so the drug may not prove effective or safe enough for wider use. Side effects and limited benefit are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sichuan Kelun Botai Biopharmaceutical Co.
Chengdu, Sichuan, 610000, China
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