PARKINSON DISEASE

This study compares a new adaptive form of deep brain stimulation (aDBS) to the standard continuous stimulation (cDBS) in 130 people with Parkinson's disease. The goal is to see if aDBS increases the amount of time patients feel good and can move well without bothersome side effe…

This early study tests whether a surgically implanted device that stimulates a specific brain network (SCAN) can improve movement problems in people with Parkinson's disease. Three adults with Parkinson's will receive the implant and be followed for 12 months. The main goal is to…

This study tests whether a new drug called BHV-8000 can slow the worsening of symptoms in people recently diagnosed with Parkinson's disease. About 550 adults aged 40-85 with early Parkinson's will receive either the drug or a placebo. The main goal is to see if the drug delays p…

This study follows 1,000 people with Parkinson's disease, essential tremor, or dystonia who receive an Abbott deep brain stimulation (DBS) system. Researchers will measure changes in movement symptoms and track any serious side effects over five years. The goal is to confirm the …

This study tests whether high-intensity treadmill exercise can slow the worsening of motor symptoms in people with early-stage Parkinson's disease. 370 participants who have not yet started medication will be assigned to either moderate or high-intensity treadmill workouts four t…

This study looks at whether a 12-month home-based aerobic exercise program can help improve thinking skills and slow cognitive decline in people with Parkinson's disease who also have mild memory or thinking problems. Researchers will measure changes in movement, mood, and blood …

This study tests whether vinpocetine, a supplement that may improve blood flow and reduce inflammation, can safely help control Parkinson's disease symptoms. Researchers will measure changes in movement and daily function using a standard rating scale, and also check blood marker…

This study compares deep brain stimulation (DBS) plus medication against medication alone for Parkinson's patients who also have impulse control disorders, like gambling or compulsive behaviors. About 60 people aged 70 or younger will be randomly assigned to one of the two groups…

This study looks at how well and how safely the drug opicapone works for people with Parkinson's disease who have early motor fluctuations (uncontrolled movements). About 200 adults aged 30 and older in Italy will take part. Researchers will check if symptoms improve after 12 mon…

This study tests a gene therapy called AAV2-GDNF for people with moderate Parkinson's disease. The treatment is delivered directly to a brain area involved in movement. The goal is to see if it safely improves daily function. About 127 adults aged 45-75 with Parkinson's for 4-10 …

This early-stage trial tests a new treatment called NouvNeu001 in 5 people with advanced Parkinson's disease. The goal is to see if it is safe and if it can improve movement and other symptoms. Participants receive a transplant of special cells and are followed for up to 96 weeks…

This early-stage trial tests if it's safe to transplant special brain cells made from a patient's own skin cells into their brain to treat Parkinson's disease. The study involves 8 people with moderate Parkinson's. The main goal is to check for side effects, but researchers will …

This early-stage study tests a new medicine called LY4006896 in healthy people and those with Parkinson's disease. The main goal is to check if the drug is safe and how the body processes it. About 127 participants will receive either the drug or a placebo through an IV. This res…

This study tests whether playing gentle sounds at night to enhance deep sleep can slow the progression of Parkinson's disease in 80 people with early-stage Parkinson's or a related sleep disorder (iRBD). Participants wear a headband and headphones for 18 months and undergo tests …

This study tests whether silymarin, a natural antioxidant from milk thistle, can protect brain cells and help manage symptoms in people with Parkinson's disease. Fifty adults aged 45–65 who are already on standard Parkinson's medication will take silymarin alongside their usual t…

This study tests an experimental drug called NEU-411 in 150 people aged 40-80 with early Parkinson's disease who have a specific genetic profile linked to higher activity of the LRRK2 pathway. Participants will be randomly assigned to receive either NEU-411 or a placebo for about…

This program offers free continued treatment with BIA 28-6156 for people with Parkinson's disease who have a specific change in the GBA1 gene and finished the ACTIVATE study. The goal is to keep providing the study drug while patients wait for possible future options. It is not a…

This study tests an experimental drug called BIIB122 in 50 people who have a specific genetic form of Parkinson's disease (LRRK2-PD). The main goal is to check the drug's safety and how it affects certain markers in the body over 12 weeks. Participants will be randomly assigned t…

This study tests whether metformin, a standard diabetes medication, can safely improve movement and quality of life in people with Parkinson's disease. Researchers will enroll 60 adults aged 50 and older who are already taking standard Parkinson's medication. The study measures c…

This study aims to improve walking and balance in 60 people with Parkinson's disease who already have a brain implant (deep brain stimulation). Researchers will use MRI and CT scans to create a computer model of each patient's brain and then find the best stimulation settings to …

This study tests whether etoricoxib, an anti-inflammatory drug, can improve symptoms in people with Parkinson's disease when added to their usual treatment. The trial will include 60 adults with Parkinson's and measure changes in movement and daily function. The goal is to see if…

This study tests whether celecoxib, an anti-inflammatory drug, can help control symptoms of Parkinson's disease. Researchers will enroll 80 adults with Parkinson's to see if the drug improves movement and daily function. The goal is to reduce brain inflammation that may worsen th…

This early-stage study tests a new oral drug called HL-400 in 86 healthy volunteers aged 18 to 65. The drug aims to reduce inflammation linked to Parkinson's disease. The main goal is to check safety and how the drug moves through the body, not yet to treat the disease.

This study tests whether montelukast, a common asthma medication, can help control symptoms of Parkinson's disease. Researchers will give the drug to 60 adults with Parkinson's who are already taking levodopa. The main goal is to see if montelukast improves movement, mood, and da…

This study tests whether dapansutrile, a drug that targets inflammation, is safe and can reduce brain and body inflammation in people with early Parkinson's disease. 36 participants will take the drug or a placebo daily for 6 months, with brain scans and spinal fluid tests to mea…

This study looks at how genetics and aerobic exercise together might slow the progression of Parkinson's disease. Two hundred people with Parkinson's will take part in a community-based cycling program three times a week for a year. Researchers will track motor symptoms and think…

This early-stage trial tests a gene therapy called IPS101A in 6 people with advanced Parkinson's disease (stages 4-5) whose symptoms are not well-controlled by current medications. The main goal is to check safety and find the best dose, while also looking for any signs of improv…

This study will test whether people with Parkinson's disease can stick to a Mediterranean-style diet for 18 months and whether it helps their gut health and symptoms. About 40 participants without dementia will be randomly assigned to either the special diet or a standard diet. R…

This study is testing three new PET/CT scans to see if they can detect alpha-synuclein, a protein linked to Parkinson's disease and similar conditions. Researchers will scan 500 adults who have or are suspected of having these diseases. The goal is to improve diagnosis by measuri…

This study is testing whether a smartphone app can help diagnose and monitor brain diseases like dementia, Parkinson's, multiple sclerosis, and motor neuron disease by recording and analyzing speech. Researchers will compare speech patterns from 150 people with these conditions t…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose dystonia, a movement disorder. The goal is to see if the AI can correctly identify dystonia and reduce the time it takes to get a diagnosis. About 1,000 people w…

This study aims to improve how Parkinson's disease is diagnosed and tracked. Researchers will collect eye movement, pupil, and walking data from 100 people with Parkinson's or similar conditions. They will use this data to train computer models that could help detect the disease …

This study is testing a special PET scan (18F-DOPA) to see if it can better detect and measure several conditions, including congenital hyperinsulinism in children, neuroblastoma, neuroendocrine tumors, Parkinson's disease, Lewy body dementia, and brain tumors. About 800 children…

This study looks at whether tissue samples taken during a routine colonoscopy can find signs of Parkinson's disease. Researchers want to see if a protein called alpha-synuclein is present in the colon of people with Parkinson's. The goal is to catch the disease earlier, before mo…

This study is testing a new, non-invasive eye scan that uses different colors of light to look for signs of brain diseases like Alzheimer's, Parkinson's, and dementia. Researchers will scan the eyes of 930 adults aged 30 and older, including those with these conditions and health…

This study looks at whether increasing physical activity using a motivational smartphone app can slow down cognitive decline in people with isolated REM sleep behavior disorder (iRBD), an early sign of Parkinson's disease. Researchers will enroll 80 people with iRBD and 50 health…

This study tests whether a supplement called tributyrin can improve memory, thinking, walking, and balance in people with Parkinson's disease who also have cognitive problems. About 45 adults will take either tributyrin or a placebo three times a day for 80-100 days. Before and a…

This study tests whether electrical spinal cord stimulation is safe for people with Parkinson's disease who have a painful bent spine (camptocormia). Six participants will receive the stimulation and be monitored for side effects for about 10-11 months. The goal is to see if this…

This study looks at how three types of exercise—cardio, resistance training, or a mix of both—affect sleep quality in people with Parkinson's disease. Researchers will track 150 participants over 12 weeks, measuring sleep with both sleep lab tests and questionnaires. The goal is …

This study tests whether speech amplification devices can help people with Parkinson's disease or related conditions who have soft, weak voices (hypophonia). Researchers will measure how well these devices improve loudness, voice quality, and clarity. The goal is to create person…

This study tests whether a new swallowing therapy works as well when done via telehealth as in person for people with Parkinson's disease. Swallowing problems are common in Parkinson's and can lead to pneumonia, a leading cause of death. The study will enroll 120 participants to …

This study tests whether balance exercises done at home with wearable sensors can help older adults with Parkinson's disease improve their stability and reduce fall risk. Researchers will enroll 80 people aged 55-85 with mild to moderate Parkinson's. Participants will be guided r…

This study tests whether pyridostigmine, a drug that boosts nerve signals, can help with constipation in people with Parkinson disease. Constipation is a common and bothersome symptom that often starts years before movement problems. Sixteen adults with Parkinson disease will tak…

This study is for people with Parkinson's disease who experience OFF episodes—times when symptoms return between medication doses. It will track how patients use SL-APO, a fast-acting treatment, to find the best dosing approach. The goal is to improve patient satisfaction and bal…

This study looks at whether using a mobile app called SpiroGym, which gives real-time visual feedback, can make breathing muscle training more effective for people with Parkinson's disease. Researchers will compare training with and without the app in 30 participants. The goal is…

This study looks at two different exercise routines for veterans with moderate Parkinson's disease. One group exercises a lot for one week, then rests for three weeks. The other group exercises every week without breaks. Researchers will measure walking speed, overall physical ac…

This study tests a new way to help people with Parkinson's improve their balance and reduce falls. Participants will play exercise video games while getting feedback on their brain activity to see if this combination works better than exercise alone. The study involves 100 people…

This study looks at how stereotactic radiosurgery (a precise type of radiation) affects quality of life and tremor severity in people with essential tremor or Parkinson's tremor whose medications aren't enough. About 60 participants will fill out questionnaires and have their tre…

This study tests whether a new type of deep brain stimulation (DBS), called patterned stimulation, is safe and tolerable for people with Parkinson's disease to use at home. About 60 adults who already have stable DBS will try the new pattern for two weeks. The goal is to see if t…

This study tests a new therapy called CereGate for people with Parkinson's disease who experience freezing of gait—a sudden inability to move their feet while walking. The therapy is used alongside their usual medication and deep brain stimulation. Researchers will measure change…

This study tests whether adding gentle electrical stimulation to the brain and spine can improve walking and balance in people with Parkinson's disease who have trouble with falls and movement. About 71 people (51 with Parkinson's and 20 healthy volunteers) will take part. Partic…

This study tests whether sleeping on a gently rocking bed (Somnomat Casa) for two months can help people with Parkinson's disease sleep better and ease their symptoms. Fifteen participants will use the bed at home, and researchers will check how well it works and if people like i…

This study tests whether a continuous apomorphine pump can reduce muscle stiffness and improve comfort for people with advanced Parkinson's disease who are nearing the end of life. The trial will enroll 80 patients receiving home hospital care. The goal is to ease suffering and i…

This study looks at whether doing intense aerobic exercise before virtual reality training can improve balance and help the brain adapt better in people with Parkinson's disease. Sixteen participants will be split into two groups: one does high-intensity exercise plus VR, the oth…

This study tests whether a newer, directional type of deep brain stimulation can better improve movement problems in people with Parkinson's disease compared to standard stimulation. Ten participants who already have brain electrodes will have their stimulator settings changed to…

This study tests a smart wearable device called gaitQ that uses cues to help people with long-term movement conditions like Parkinson's disease, stroke, multiple sclerosis, and arthritis walk better. Researchers will measure walking speed, step length, and safety in 150 participa…

This study tests an experimental oral liquid called HBI-002, which contains a low dose of carbon monoxide, in 36 adults with Parkinson's disease. Participants take the liquid daily for 14 days to see if it is safe and tolerable. The goal is to gather early information on how the …

This study follows 120 people with Parkinson's disease who are using a continuous apomorphine infusion pump (ONAPGO™) to manage their symptoms. Researchers will track how long it takes to find the right dose, how often other Parkinson's medications need to be adjusted, and how pa…

This study tests a 12-session walking training program for people with Parkinson's disease. Participants will walk on a treadmill and overground while following a metronome beat at slow and fast speeds to improve step size and speed. The goal is to see if this training helps them…

This study tests whether a non-invasive magnetic brain stimulation technique (rTMS) can improve balance and stability in people with Parkinson's disease. Forty participants with mild to moderate Parkinson's will receive high-frequency rTMS and have their balance measured using a …

This study tests whether listening to a steady beat (like a metronome) can improve walking in people with Parkinson's disease who have a brain pacemaker (deep brain stimulation). Ten participants will walk with and without the beat, and with their brain pacemaker on and off. Rese…

This study tests a non-invasive device that gently stimulates a nerve in the ear, timed with breathing, to see if it can improve apathy (lack of motivation) in people with Parkinson's disease. Sixty participants will receive either the real stimulation or a sham (fake) version fo…

This study tests a non-invasive device that sends mild electrical pulses to the spinal cord to improve walking and balance in people with Parkinson's disease. The treatment targets movement problems that don't respond well to standard medications. Twenty adults with Parkinson's w…

This study tests whether adding visual feedback exercises using a laser pointer to standard physical therapy can improve balance and mobility in people with Parkinson's disease. About 32 participants with mild to moderate Parkinson's will be split into two groups: one doing stand…

This small study tests if using a special standing desk that moves (dynamic standing) can improve walking and motor symptoms in people with Parkinson's disease. Five participants will attend 12 sessions to compare dynamic standing, regular standing, and sitting. The goal is to se…

This study tests a temporary, minimally invasive spinal cord stimulation device to help people with advanced Parkinson's disease who experience freezing of gait—a sudden inability to move their feet. The goal is to improve walking stability and reduce fall risk. Five participants…

This study tests whether a non-invasive device that uses focused ultrasound waves on the brain can safely improve movement problems in people with Parkinson's disease. About 60 adults with Parkinson's will receive either real or sham (fake) ultrasound sessions. Researchers will m…

This study tests two approaches to help people with early-stage Parkinson's disease stay active and improve their quality of life. One group uses an online self-management program, another attends in-person task training, and a third group receives no extra treatment. The goal is…

This study explores whether listening to personalized music can help reduce apathy (lack of motivation and emotion) in people with Parkinson's disease. Researchers will use brain scans to understand how music affects the brain's reward and motivation centers. Fifty participants w…

This study tests whether a 6-week home-based virtual reality program, guided remotely by a therapist, can improve memory, attention, and social skills in adults aged 40-80 with early memory concerns. Participants will be randomly assigned to either the VR program or traditional p…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve cognitive problems and mood in people with schizophrenia, autism, bipolar disorder, depression, or Parkinson's disease. Researchers will give TMS to the …

This program provides early access to the investigational drug tavapadon for people with Parkinson's disease before it is officially approved. It is for those who have no other suitable treatment options and cannot join ongoing clinical trials. A doctor must decide if the potenti…

This study tests whether a home-based, virtually-supervised exercise program combining high-intensity endurance and resistance training is safe and feasible for people with Parkinson's disease. It also looks at how exercise affects thinking skills and related biological markers. …

This study tests a new way to use deep brain stimulation (DBS) for Parkinson's disease. Standard DBS helps movement but can sometimes cause thinking or mood problems. The researchers want to see if adding a low-frequency signal to a different part of the brain, along with the usu…

This pilot study tests a new, faster version of transcranial magnetic stimulation (TMS) to treat apathy in people with Parkinson's disease. Fifteen participants will receive eight short stimulation sessions each day for six days over two weeks. The goal is to see if the treatment…

This study tests a device called Cue2Walk that automatically detects when people with Parkinson's disease freeze while walking and provides rhythmic cues to help them keep moving. The goal is to see if it improves quality of life and reduces freezing compared to usual care. About…

This study tests whether varenicline, a drug already used to help people quit smoking, can reduce falls and improve the ability to walk while doing another task in people with Parkinson disease. About 102 participants will receive either varenicline or a placebo for one year. The…

This study tests whether a daily probiotic supplement can reduce depression in people with Parkinson's disease. Sixty adults aged 40–80 with mild to moderate Parkinson's and depression will take either a multi-strain probiotic or a placebo for 12 weeks. Researchers will measure c…

This study tests a new way to use deep brain stimulation (DBS) — like a pacemaker for the brain — that automatically adjusts stimulation based on what the person is doing, like sitting, standing, or walking. The goal is to see if this "adaptive" DBS is safe and can improve walkin…

This study tests whether adding supervised water exercises to a home workout plan helps people with Parkinson's disease improve their daily activities, walking, balance, and mood. Forty-two adults aged 40-80 with mild to moderate Parkinson's will be randomly assigned to either a …

This study tests a non-invasive brain stimulation technique called accelerated Temporal Interference Stimulation (TIS) to see if it can improve motor and speech problems in people with Parkinson's disease or similar conditions. About 60 participants will receive either real or sh…

This study tests whether adding motor imagery (mentally practicing movements without actually moving) to standard physical therapy can improve balance and reduce fear of movement in people with Parkinson's disease. About 42 participants will be randomly assigned to either standar…

This study tests a new way to help people with Parkinson's disease move better. Participants will watch their own 3D motion recordings in a virtual reality headset and then practice those movements. The goal is to see if this training can reduce slowness of movement (bradykinesia…

This study tests a non-invasive brain stimulation method called MRI-guided transcranial direct current stimulation (mgTDCS) to see if it can improve depression, apathy, and working memory in people with Parkinson's disease. About 40 participants with Parkinson's and elevated depr…

This study tests a new nasal spray called XJN010 for people with Parkinson's disease who have 'off' episodes—times when their regular medication stops working and symptoms return. The spray aims to quickly improve movement and reduce the time spent in the 'off' state. The trial i…

This study tests whether a daily nasal spray containing insulin and glutathione can safely improve symptoms in people with Parkinson's disease. About 56 participants will receive either the active spray or a placebo, in addition to their usual medications. The main goal is to see…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce impulse control disorders in people with Parkinson's disease who take dopamine replacement therapy. Twenty participants will receive both real and sham (fake) stimulation in random order, t…

This study tests whether adding musical sounds that match a person's movements (sonification) to standard physical therapy can improve walking in people with Parkinson's disease, stroke, or multiple sclerosis. About 120 adults will be randomly assigned to standard rehab or rehab …

This study offers speech therapy and counseling to Korean immigrants with Parkinson's disease and their caregivers. The goal is to improve speech clarity and reduce the social and emotional impact of speaking difficulties. Researchers will measure changes in speech intelligibilit…

This study tests whether special rotational exercises can lower fall risk and improve balance and mobility in people with early-stage Parkinson's disease. Researchers will enroll 50 adults aged 50-70 who have stable symptoms. Participants will be assigned to either the rotational…

This study looks at whether using a CPAP machine (commonly used for sleep apnea) can help people with autonomic failure who have high blood pressure when lying down and low blood pressure when standing. About 59 adults aged 40-80 with conditions like Parkinson's or multiple syste…

This study is testing whether adding a gentle electrical current to the brain (called tDCS) during physical exercise can improve walking and movement in people with Parkinson's disease. Researchers will measure things like walking speed, step length, and reaction time in 100 part…

This study tests a wearable device that gives feedback on swallowing muscle activity to help people with swallowing problems from stroke or Parkinson's disease. About 120 adults aged 50-90 will either do swallow therapy in person or at home via telehealth. The goal is to see if t…

This study tests an experimental drug called AP-472 in 150 people with Parkinson's disease who have 'OFF' episodes—times when their regular medication stops working well. Participants take AP-472 or a placebo alongside their usual levodopa for 8 weeks. The goal is to see if AP-47…

This study explores whether gentle light, sound, and touch stimulation can safely change brain activity in people with mild Parkinson's disease. Researchers will measure brain waves before, during, and after stimulation to see if it boosts helpful gamma waves. The goal is to find…

This study tests whether following a Mediterranean diet for three months after deep brain stimulation surgery helps Parkinson's patients control weight gain and improve body composition. Twenty-four adults aged 45-64 who are scheduled for this surgery will be randomly assigned to…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve walking and other motor skills in people with progressive supranuclear palsy, corticobasal syndrome, or Parkinson's disease. Twenty participants will receive both real and sham stimulation…

This study tests whether fexofenadine, a common allergy medication, can improve quality of life for people with Parkinson's disease who are already on standard treatment. Researchers will enroll 46 adults aged 50 and older with mild to moderate Parkinson's. The goal is to see if …

This study looks at how well the drug Foslevodopa/Foscarbidopa works for Italian adults with advanced Parkinson's disease in everyday medical practice. About 270 participants will receive the drug as a continuous infusion under the skin for up to 12 months. The main goal is to se…

This study tests a smartphone app designed to help people with Huntington's or Parkinson's disease feel less anxious. The app works by training users to interpret everyday situations in a less threatening way. Researchers will enroll 136 participants to see if the app improves an…

This study tests whether a gentle, non-invasive brain stimulation technique called tDCS can improve thinking and memory in people with Parkinson's disease who have mild cognitive problems. About 36 participants will receive either real or fake stimulation to see if it helps resto…

This study tests whether doing fast bodyweight exercises at home, guided remotely by a physiotherapist, can reduce bradykinesia (slowness of movement) in people with Parkinson's disease. 46 participants aged 50+ with mild to moderate Parkinson's will be randomly assigned to eithe…

This study is testing a remote coaching program called Engage-Qatar PD to help people with Parkinson's disease in Qatar become more physically active. The program is designed to be used online and tailored to the local culture. Researchers will work with 40 participants to see if…

This study tests whether turning on an extra deep brain stimulation (DBS) electrode in a brain region called the GPe can improve severe insomnia in people with Parkinson's disease. Ten participants aged 40-80 with Parkinson's for 7-20 years and severe insomnia will be enrolled. T…

This study tests whether a non-invasive brain stimulation technique called patterned repetitive transcranial magnetic stimulation (prTMS) can reduce bradykinesia (slowness of movement) in people with Parkinson's disease. Researchers will compare active stimulation to a sham (fake…

This study looks at why many people with Parkinson's disease crave sugary foods and whether eating fast-acting sugars improves their symptoms. Researchers will give 50 participants a sugar drink and a placebo on different days, measuring insulin, blood sugar, and movement. The go…

This study looks at how different types of treadmill training affect the gut bacteria and movement in people with Parkinson's disease. Sixty participants will be split into three groups: standard physical therapy, treadmill training, or treadmill training with virtual reality. Re…

This study explores whether the gut's nervous system can show early signs of Parkinson's disease. Researchers will collect gut tissue and microbiome samples during routine screening colonoscopies from 60 people aged 45-75, including those with Parkinson's, those at risk, and heal…

This study tests if small motion sensors can detect internal tremors—shaking felt inside the body—in people with Parkinson's disease. Researchers will compare 60 participants (30 with Parkinson's and 30 healthy volunteers) to see if these tremors have a unique rhythm. The goal is…

This study follows 150 people with early-stage Parkinson's disease to see how symptoms like walking problems and thinking changes differ between two types: one that starts in the brain and one that starts in the body. Participants will have yearly check-ups, brain scans, and test…

This study looks at how different parts of the brain talk to each other to control movement in people with Parkinson's disease. During planned deep brain stimulation (DBS) surgery, researchers will place a thin strip of sensors on the brain's surface to record activity. The goal …

This study looks at how brain activity related to thinking and self-control affects walking in people with Parkinson's disease. Researchers will measure walking patterns, thinking tests, and brain waves in 70 participants (both with Parkinson's and healthy older adults). The goal…

This study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people already scheduled for DBS surgery will have temporary brain recordings during their procedure. The goal is to understand t…

This study aims to create a large, open database of clinical, motor, and non-motor information from people with Parkinson's disease and healthy volunteers in Brazil. Researchers will collect data through questionnaires, movement tests, and clinical scales to better understand the…

This study follows 4,500 people with Parkinson's disease, early signs of it, and healthy volunteers over time. Researchers collect medical data, brain scans, and blood samples to understand how the disease progresses. The goal is to find reliable markers that can be used in futur…

This study aims to learn how Parkinson's disease affects Black and African American people. Researchers will collect genetic and health information from 2,000 participants aged 50 and older, including those with and without Parkinson's. The goal is to find genetic risk factors un…

This study looks at why some people with Parkinson's disease suddenly feel like their feet are glued to the floor, known as freezing of gait. Researchers will use special brain recordings from already-implanted devices to compare brain activity in people with and without this sym…

This study looks for easy ways to find early signs of multiple sclerosis and Parkinson's disease in drivers. Researchers will test 200 people with these conditions using computer tasks that measure attention, reaction time, and impulse control. The goal is to make routine driver …

This study uses a special PET scan to measure brain inflammation in people with early or suspected Parkinson's disease and in healthy volunteers. Researchers will track changes over two years to see how inflammation relates to disease progression. The goal is to better understand…

This study aims to develop new ways to measure how much energy people with Parkinson's use during dance classes. Researchers will use cameras, wearable activity monitors, and questionnaires to track movement. The goal is to better understand how dance intensity relates to daily a…

This study looks at how deep brain stimulation (STN-DBS) affects speech in people with Parkinson's disease and impulse control issues. Researchers will record voices of 60 participants before and after treatment to measure changes in clarity, emotion, and thinking. The goal is to…

This study looks at brain activity related to speech in people with Parkinson's disease, essential tremor, or dystonia. Participants are already scheduled for deep brain stimulation (DBS) surgery. Researchers will record brain signals during speech tasks to better understand how …

This study aims to understand how inflammation affects the brain in Parkinson's disease. Researchers will give a mild inflammatory substance (LPS) to 30 participants, including people with Parkinson's and healthy volunteers, and use special brain scans to measure the response. Th…

This study looks at how balance problems, walking difficulties, physical activity levels, and sleep quality are connected in people with Parkinson's disease. Researchers will compare 34 participants with Parkinson's to healthy adults of similar age to see which issues are due to …

This study is testing whether a new, low-cost brain scan can find early signs of Alzheimer's and Parkinson's disease. Researchers will compare brain scans from 120 people — including those at risk for Alzheimer's, those with Parkinson's, and healthy volunteers — to see if they ca…

This study follows 100 people with Parkinson's disease who visit a clinic offering complementary treatments like homeopathy, herbalism, hypnosis, and healing, alongside their usual medical care. Researchers will track symptoms and well-being using questionnaires every three month…

This study looks at how Parkinson's disease affects the brain's ability to control actions, like stopping or switching tasks. Researchers will have 50 people with Parkinson's do joystick tasks to measure their reaction times and accuracy. The goal is to understand how dopamine me…

This study looks at how the brain works in people with Parkinson's disease who are getting Deep Brain Stimulation (DBS). The goal is to learn more about brain signals related to movement and thinking, which could help make DBS therapy better in the future. About 30 adults with Pa…

This study aims to create a model that better predicts how different types of dementia will progress over time. Researchers will follow 500 people with early dementia or mild cognitive impairment, using blood tests and thinking assessments. The goal is to improve prognostic confi…

This study aims to find new markers in our DNA, proteins, and metabolism that could help diagnose and track brain diseases like Alzheimer's, Parkinson's, and ALS. Researchers will analyze samples from 1,200 people with these conditions using advanced technology. The goal is to be…

This study looks at sleep problems in people with Parkinson's disease, those with a sleep disorder called REM sleep behavior disorder (iRBD), and healthy volunteers. Researchers will use overnight sleep tests to compare sleep quality among the three groups. The goal is to better …

This study uses a non-invasive brain stimulation technique called TMS to measure brain activity in 52 people with Parkinson's disease. The goal is to see if these measurements can tell the difference between normal thinking, mild cognitive impairment, and dementia, and predict fu…

This study looks at how pain and automatic body functions (like digestion and sweating) affect people with Parkinson's disease or multiple system atrophy. Researchers will track 280 participants during their usual rehabilitation to see if symptoms improve and how quality of life …

This study aims to find early signs of Parkinson's disease in 2000 people aged 50-99 who do not yet have the condition. Participants will be followed for five years to track changes in risk markers and symptoms. The goal is to improve early detection and understand how Parkinson'…

This study looks at whether tissue samples taken during a routine colonoscopy can find signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). Researchers are checking for a protein called alpha-synuclein in colon tissue from 40 adults aged 40-99 who already have Parki…

This study aims to understand the brain activity linked to risk-taking and reward-seeking behaviors in people with Parkinson's disease. Researchers will record brain signals during deep brain stimulation surgery while participants play a gambling task. The goal is to learn how ce…

This study is testing whether computer analysis of speech can reliably detect changes in movement, mood, and thinking in people with Parkinson's disease. Researchers will record voices from 80 participants and compare them to standard clinical tests. The goal is to develop a simp…

This study is testing whether a new digital test battery called Mindmore Distance can accurately assess thinking and memory skills in people with neurological conditions like traumatic brain injury, stroke, multiple sclerosis, Parkinson's disease, epilepsy, or brain tumors. Resea…

This study looks at how deep brain stimulation (DBS) affects walking and other movements that don't improve with standard Parkinson's medication. About 36 adults with Parkinson's who already have a Medtronic Percept DBS device will take part. Researchers will record brain signals…

This study looks at how Parkinson's disease impacts breathing, inspiratory muscle strength, physical fitness, and aerobic capacity. Researchers will compare 100 people aged 50-80 with Parkinson's to healthy volunteers of similar age. Participants undergo tests like breathing meas…

This study tests whether a small, wearable device that vibrates in time with each step can help people with Parkinson's disease walk more automatically and steadily. Researchers will measure brain activity and walking patterns in 60 participants as they use either personalized or…

This study aims to learn more about the brain activity that causes thinking and memory problems in people with Parkinson's disease. Researchers will record brain signals during deep brain stimulation surgery in 75 adults with Parkinson's. They will measure how brain areas communi…

This study aims to create a large national collection of genetic and medical data from 230 people with Parkinson's disease or a related sleep disorder. Researchers will analyze participants' complete DNA to find rare genetic changes that may cause or influence the disease. They w…

This study uses a special brain scan (PET/MRI) to measure inflammation in the brains of people with Parkinson's disease and compare it to healthy volunteers. The goal is to see if people with Parkinson's have higher levels of brain inflammation. No treatment or medication is give…

This study looks at how Parkinson's disease impacts social behavior and quality of life. Researchers will compare 500 adults with Parkinson's to people of the same age without the condition. Participants complete surveys and tasks about daily activities, mood, memory, and social …

This study aims to find out how common functional neurological disorders are in people who already have a movement disorder like Parkinson's disease, tremor, or dystonia. Researchers will examine 216 participants with neurological exams, thinking tests, and questionnaires. The go…

This study looks at brain activity related to non-motor symptoms like attention and thinking in people with Parkinson's disease. Researchers will record brain surface signals during routine deep brain stimulation surgery. About 140 participants who are already scheduled for surge…

This observational study looks at how gut bacteria relate to brain changes in healthy aging and in people with early Alzheimer's, Parkinson's, or multiple sclerosis. Researchers will collect stool and blood samples, perform brain scans, and run memory tests on 200 participants. T…

This study looks at whether changing the amount of carbidopa in Parkinson's medication can help with a common problem: a sudden drop in blood pressure when standing up, which can cause dizziness or fainting. About 36 people with Parkinson's disease or multiple system atrophy (MSA…

This study looks back at the medical records of up to 5,000 people who have or are eligible for deep brain stimulation (DBS) to treat Parkinson's disease, essential tremor, or dystonia. Researchers want to see how well DBS improves symptoms over time in everyday medical practice.…

This study looks at how deep brain stimulation (DBS) changes brain activity in people with Parkinson's disease. Researchers will record brain signals during DBS surgery to create detailed maps that could help doctors target the right brain areas and program the device more precis…

This study aims to find a new marker for Parkinson's disease by using special brain scans (PET, SPECT, and MRI). Researchers will track 44 people over time to see how certain brain cells change as the disease progresses. The goal is to better understand Parkinson's, not to test a…

This study creates a registry for up to 300 people with Gaucher disease or GBA-related Parkinson's who are already taking ambroxol (a common cough medicine) off-label. Researchers will collect real-world safety and effectiveness data from patients, parents, and doctors. No new tr…

This study is collecting information from 200 people with Parkinson's disease, dystonia, essential tremor, or other movement disorders who are scheduled to receive a standard radiofrequency (RF) ablation treatment. The goal is to see how the procedure affects patients' quality of…

This study looks at how changing the strength of deep brain stimulation affects sleep in people with Parkinson's disease. Ten participants will try three different stimulation levels over six weeks while their brain activity and sleep quality are recorded. The goal is to find whi…

This study looks at how deep brain stimulation (DBS) affects the ability to stop or control actions in people with Parkinson's disease. Researchers will measure brain activity and test impulse control using simple computer tasks before, during, and after DBS surgery. The goal is …

This study aims to find early biological markers for Parkinson's disease, multiple system atrophy, and Lewy body dementia by analyzing samples from the nose, blood, and urine. Researchers will combine clinical exams, brain scans, and advanced lab tests to build a model that can t…

This study aims to understand how the brain's outer layers handle thinking and decision-making in people with Parkinson's disease. Researchers will insert a thin, high-tech probe into the brain for a short time during awake deep brain stimulation surgery. The study involves 15 ad…

This study uses PET, SPECT, and MRI brain scans to better understand brain changes in Parkinson's disease. Researchers hope to find a biomarker that can help develop new medications to slow symptom progression. The study involves 42 adults aged 25-85 with Parkinson's disease.

This study looks at whether taking immunosuppressive drugs for other health issues can slow down Parkinson's disease. Researchers will compare two groups of people with Parkinson's: those who have been on long-term immunosuppressive medication and those who have not. The goal is …

This study looks at how midodrine and droxidopa, two drugs used for low blood pressure upon standing, affect the veins in the abdomen of people with autonomic failure. About 34 adults aged 40-80 with conditions like multiple system atrophy, pure autonomic failure, or Parkinson di…

This study looks at how the brain and balance system work together when people with Parkinson's disease start walking, turn, or change speed. Researchers will use gentle electrical stimulation and brain wave recordings to find patterns linked to freezing of gait. The goal is to b…

This study follows nearly 3,000 people, including healthy volunteers and those with memory or movement problems, to track how brain diseases like Alzheimer's and Parkinson's develop over time. Researchers use advanced brain scans and tests to find early signs of disease. The goal…

This study looks at how alcohol affects tremors in people with essential tremor, dystonia, and Parkinson's disease. 45 participants will receive either an alcoholic drink or a non-alcoholic placebo on two separate days. Researchers will measure tremor changes using a device and c…

This study is building a research database of people with Parkinson's disease and related disorders. Researchers will collect health information, brain images, and biological samples over time to better understand the disease's long-term effects and genetic factors. The goal is t…

This study looks at why deep brain stimulation (DBS) for Parkinson's disease can sometimes cause thinking or memory problems. Researchers will use brain scans to compare how the brain works with the stimulator turned on versus off. The goal is to help doctors choose the best stim…

This study is looking for better ways to diagnose Parkinson's disease and two similar conditions (Multiple System Atrophy and Progressive Supranuclear Palsy) using brain scans and artificial intelligence. Researchers will analyze scans from 90 adults to find patterns that can tel…

This study aims to find a biological marker for Parkinson's disease by using special brain scans (PET, SPECT, and MRI) in 45 people with certain genetic mutations. The goal is to better understand brain changes in Parkinson's and help develop new medications that could slow the d…

This study looks at whether letting people with Parkinson's disease choose when they get feedback helps them learn a finger-tapping task. 72 participants will either have control over their feedback or receive it on a fixed schedule. Researchers will compare how well each group r…

This study looks at how certain brain signals (beta waves) relate to movement problems in people with Parkinson's disease. Researchers will work with 25 patients already scheduled for deep brain stimulation (DBS) surgery. By adjusting stimulation in real time and measuring moveme…

This study looks at how blood pressure changes when standing up affect thinking and brain blood flow in people with Parkinson's disease. About 60 participants with and without orthostatic hypotension (low blood pressure on standing) will take thinking tests while lying down and s…

This study uses a special PET scan to measure dopamine production in the brains of people with autonomic failure, including those with Parkinson's disease, Multiple System Atrophy, or Dementia with Lewy Bodies. The goal is to find early signs that predict if a person with pure au…

This study translates a questionnaire about stomach and bowel problems (GIDS-PD) into Italian for people with Parkinson's disease. Researchers will check if the Italian version works well by testing it with 190 patients across multiple centers. The goal is to help doctors better …

This study looks at how the brain handles sensory information in people with Parkinson's disease. Researchers will measure brain activity and arm movements in 30 participants during and after deep brain stimulation surgery. The goal is to understand the brain's role in movement p…

This study aims to understand why some people with Parkinson's disease experience central pain by examining the serotonin system in the brain. Researchers will use PET and MRI scans on 34 participants to measure serotonin receptors and brain connectivity. The goal is to gather kn…

This study uses powerful MRI scanners to look at the brains of 700 people, including those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's, as well as healthy volunteers. The goal is to understand why some brains stay healthy while others develop disease. Re…

This study is testing a digital system that helps people with Parkinson's track and manage non-motor symptoms like pain, mood, and sleep problems. 30 people with Parkinson's and their care partners will use the tool for 6 months. The goal is to see if it's easy to use and helps p…