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Exercise plus VR may boost balance in Parkinson's – small study underway

NCT ID NCT06133283

Symptom relief Sponsor: The University of Texas Health Science Center at San Antonio Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tests whether doing high-intensity exercise before virtual reality training can improve balance and brain flexibility in people with Parkinson's disease. Sixteen participants will be split into two groups: one does intense exercise plus VR, the other does stretching plus VR, for 8 weeks. Researchers will measure balance, walking, and brain changes at the start, end, and 6 weeks later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high intensity endurance exercise and virtual reality gaming
What this could lead to
If it works, this could point toward a non-drug way to improve balance and brain adaptability in Parkinson's disease.
What could go wrong
This is a very small early study with only 16 people, so results may not apply widely. The exercise and VR may be too demanding for some participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Feb 2024

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Diagnosis of idiopathic PD (ages 18 -85) in Hoehn and Yahr stages 2 - 3. 2. Subjects need to demonstrate a score of equal to or greater than 23 on the Mini Mental State Examination. 3. Subjects who have a score of ≤21.5 on the Mini Balance Evaluations Systems Test (miniBESTest). Exclusion Criteria: 1. Subjects with a history of other neurological diseases (i.e., stroke, multiple sclerosis). 2. Subjects with a history of severe cardiopulmonary disease, uncontrolled hypertension, orthostatic hypotension, uncontrolled diabetes, severe osteoporosis, severe arthritis affecting their lower extremity joints. 3. Subjects with a history of PD-specific surgical procedures such as deep brain stimulation etc. 4. Subjects with a history of head injury. 5. Subjects with a history of seizures or epilepsy. 6. Subjects who are currently pregnant. 7. Individuals who use of medications that could alter corticomotor excitability or increase risk of seizure. 8. Individuals with skull abnormalities, fractures or unexplained, recurring headaches.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson disease

Contacts and locations

Locations

  • UT Health San Antonio- Dept. of Physical Therapy

    San Antonio, Texas, 78229, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.