PARKINSON DISEASE

This study tests whether lecanemab, a drug that clears amyloid plaques in Alzheimer's disease, can also help people with Parkinson's disease who have amyloid buildup in their brains. About 60 adults aged 50-90 with mild cognitive impairment or early dementia will receive lecanema…

This study tests a single injection of AB-1005 gene therapy directly into the brain for Japanese adults with moderate Parkinson's disease. The goal is to see if it is safe and can improve daily movement and reduce 'off' time. Eight participants will be followed for 18 months.

This study tests an oral drug called GT-02287 in 111 people with early Parkinson's disease. Participants will receive either a low dose, high dose, or placebo for 48 weeks. The goal is to see if the drug can improve daily movement and motor symptoms, and to check its safety and e…

This study tests whether a mostly plant-based diet (the New Nordic diet) can improve gut health and reduce inflammation in people with Parkinson's disease. Researchers will ask 75 participants to follow this diet for several weeks and will measure changes in their gut bacteria, b…

This early-stage trial tests a one-time injection of lab-grown dopamine-producing cells into the brains of 12 people with advanced Parkinson's disease. The goal is to see if the procedure is safe and can improve motor function and quality of life. Participants must be 55-75 years…

This study tests a new way to use deep brain stimulation (DBS) in people with early-stage Parkinson's disease. The goal is to see if targeting a specific brain area can slow or stop motor symptoms from getting worse. Forty participants will receive either active DBS plus medicati…

This study tests whether a smartphone app can help doctors personalize Parkinson's medication to prevent impulse control disorders—like compulsive gambling or shopping—that affect up to half of patients. About 528 adults with early Parkinson's will be randomly assigned to standar…

This study tests whether a supervised eye-exercise program can help people with Parkinson's disease move better, keep their balance, and worry less about falling. Researchers will enroll 34 adults with mild-to-moderate Parkinson's and measure changes in walking, balance, and fall…

This study tests two types of exercise programs for people with Parkinson's disease: one that focuses on balance exercises (vestibular rehab) and another that combines thinking and movement tasks (dual-task training). The goal is to see which better improves memory, attention, wa…

This study tests whether a virtual reality (VR) rehab program done at home can help people with stroke or Parkinson's disease improve their movement and thinking skills. Sixty adults will either use a VR headset for rehab sessions or receive standard in-person therapy. The goal i…

This study will test whether combining virtual reality games with a hands-on therapy called proprioceptive neuromuscular facilitation can improve arm movement, reduce tremors, and help with coordination in people with Parkinson's disease. About 28 adults aged 50-80 with mild to m…

This study tests an experimental drug called FHL-301 in 32 adults with early-stage Parkinson's disease. Half will get the drug, half a placebo, and neither they nor their doctors will know which. The goal is to see if FHL-301 can safely improve motor symptoms like tremor and stif…

This study tests a new, high-dose form of non-invasive brain stimulation called accelerated theta burst stimulation to improve walking problems, like freezing, in people with Parkinson's disease. Researchers will enroll 20 participants to see if the treatment is acceptable and he…

This early study will test whether low-intensity focused ultrasound (LIFU) can safely stimulate the brain in 15 people with Parkinson's disease. The main goal is to check for side effects, but researchers will also look at whether it improves movement and thinking. Participants m…

This early-stage study tests a new drug called Lu AF28996 in 10 Chinese adults with Parkinson's disease. The main goal is to check the drug's safety and how the body processes it. Participants must have moderate Parkinson's with predictable movement fluctuations. This trial does …

This pilot study tests whether special shoes that vibrate can safely help people with Parkinson's disease who experience freezing of gait — a sudden inability to move their feet while walking. Researchers will enroll 20 participants to see if the vibration feedback is tolerable a…

This study tests whether a special 40 Hz flickering light can improve sleep in people with Parkinson's disease who have insomnia. Thirty participants will use either the flickering light or a regular light for 30 minutes each night for a week. The goal is to see if this simple, n…

This study tests a new, non-invasive brain stimulation technique called transcranial temporal interference stimulation (TIS) in 20 people with Parkinson's disease. The goal is to see if it can safely improve motor symptoms like tremor and stiffness. Participants will be randomly …

This study looks at different ways to treat overactive bladder symptoms in people with Parkinson's disease. Researchers want to see if combining behavioral therapy and medication helps those who don't improve with just one treatment. About 146 adults with Parkinson's and signific…

This study tests a robot-guided exercise program for people with Parkinson's disease. Participants will exercise three times a week for three weeks, either in person or remotely. The goal is to see if the program is safe, enjoyable, and helps improve movement and strength.

This study tests whether repeated sessions of a gentle, non-invasive brain stimulation technique called tDCS can improve movement in people with Parkinson's disease. Researchers will give 30 participants multiple tDCS sessions over a week and measure changes in motor function. Th…

This study tests whether a 10-week balance-focused exercise program can improve how people with Parkinson's disease start walking. Researchers will measure muscle activity and movement in 80 participants in Kuwait. The goal is to see if these exercises help control the leg muscle…

This study tests whether a gamification program can help veterans with Parkinson's disease become more physically active. About 110 veterans will be randomly assigned to either the gamification program or standard care. The goal is to see if game-like features can increase daily …

This early-stage trial tests a new virtual reality game system designed to help with Parkinson's disease rehabilitation. Thirty healthy volunteers aged 50-70 will try the system in four supervised sessions over two weeks. Researchers will measure how safe, easy to use, and accept…

This study tests whether virtual reality (VR) physiotherapy can improve balance, reduce fall risk, and boost exercise capacity in people with Parkinson's disease. Fifty participants aged 55-75 with mild to moderate Parkinson's will be randomly assigned to either VR-based or stand…

This study looks at how people with Parkinson's disease imagine movements, sense their own body, and fear physical activity. Researchers will measure these factors along with symptom severity and frailty in 100 participants. The goal is to better understand the connections betwee…

This study brings together 30 Italian healthcare experts to agree on the best ways to use deep brain stimulation (DBS) for Parkinson's disease. DBS uses electrical pulses to improve movement problems like tremors and stiffness. The goal is to create clear national guidelines so t…

This study looks at how sleep quality is linked to thinking abilities and disease severity in people with Parkinson's disease. Researchers will measure sleep, cognitive function, and disease stage in 75 participants during a single visit. The goal is to better understand these co…

This study tests a flexible, home-based care pathway for people recently diagnosed with Parkinson's disease and their caregivers. The program includes a booklet and website to help patients and families understand the disease and connect with local support. Researchers will measu…

This study will test whether an artificial intelligence system can accurately rate movement problems in people with Parkinson's disease by analyzing smartphone videos. Researchers will record 500 participants performing standard motor tasks and compare the AI's ratings to those o…

This study checks if a Turkish version of the Cognitive Self-Efficacy Questionnaire is a reliable and accurate tool for people with Parkinson's disease. About 100 adults aged 40-85 with Parkinson's and normal thinking skills will fill out the questionnaire twice. The goal is to h…