PARKINSON DISEASE

This study explores whether altering the gut microbiome can improve how people with Parkinson's disease respond to their medication. Researchers will first analyze gut bacteria patterns, then use antibiotics to reset the microbiome in a small group of participants. The goal is to…

This early-stage study tests the safety of a new treatment called ANPD001 for people with Parkinson disease. The treatment uses a person's own skin cells to create new dopamine-producing cells, which are then injected into the brain. The goal is to see if this approach is safe an…

This study looks at whether adding physiotherapy to deep brain stimulation (DBS) helps people with Parkinson's disease move around more safely and independently in their communities. About 60 adults who are candidates for DBS will take part. The goal is to see if the combination …

This study is for people with Parkinson's disease who are already scheduled for deep brain stimulation (DBS) surgery. Researchers want to see if placing electrodes in two brain areas instead of one can better control symptoms. They also aim to create an adaptive DBS system that a…

This early-stage trial tests whether transplanting dopamine neurons made from a patient's own stem cells into the brain is safe for people with Parkinson's disease. Six participants aged 55-80 with Parkinson's for at least 5 years will receive the injection. The goal is to see if…

This study tests whether a daily dose of tocotrienols (a form of vitamin E) can slow the worsening of Parkinson's disease symptoms. About 100 adults with Parkinson's will take either the supplement or a placebo for two years. Researchers will track changes in movement, thinking, …

This study aimed to see if a special blend of essential amino acids (AMS2434) could help people with Parkinson's disease build stronger muscles and improve mood and thinking. It was designed for adults aged 55 and older with mild to moderate Parkinson's. However, the study was wi…

This expanded access program tested the safety of multiple intravenous infusions of a patient's own stem cells (HB-adMSCs) for treating Parkinson's disease. It involved 10 patients aged 76 to 95 who did not qualify for other studies. Each patient received 200 million stem cells o…

This study tests a new treatment that uses sound waves to target a small area in the brain, aiming to improve movement problems in people with early-stage Parkinson's disease. About 67 participants will either receive this focused ultrasound treatment or continue with standard me…

This study tests a new medicine called exidavnemab in people with mild to moderate Parkinson's disease or multiple system atrophy. The goal is to see if it is safe and how the body processes it. Participants continue their usual Parkinson's medications during the trial.

This study tests an experimental drug called BIIB122 in 650 adults with early-stage Parkinson's disease. The goal is to see if BIIB122 can slow down the worsening of symptoms like movement problems and daily living challenges. Participants take a daily tablet for up to 3 years, a…

This study tests a vaccine called ACI-7104.056 in 150 people with early-stage Parkinson's disease. The goal is to see if it is safe and can train the immune system to attack a harmful protein linked to Parkinson's. Participants must be on a stable low dose of levodopa. This is no…

This early-stage study tests a gene therapy called LY3884961 in 32 people with moderate to severe Parkinson's disease who have a specific genetic change (GBA1 mutation). The treatment is given as a single injection into the fluid around the brain and spinal cord. The main goal is…

This study tests whether low-dose lithium can slow Parkinson's disease progression. About 35 people who have already completed a lithium study will take the drug for 24 more weeks. Researchers will use brain scans and blood tests to measure changes.

This study tests a smart wearable airbag that detects when someone is falling and inflates to cushion the impact. It is designed for people at high risk of falling, such as those with stroke, Parkinson's disease, or a leg amputation. The goal is to see if the device can reduce fa…

This study tests whether a 12-month lifestyle program focusing on stress, exercise, nutrition, sleep, and self-management can improve quality of life for people with Parkinson's disease. 256 participants will either work on their goals independently or with a lifestyle coach. The…

This study tests a non-surgical treatment using focused ultrasound to target a small area in the brain that controls movement. It is for people with advanced Parkinson's disease whose medication no longer controls their involuntary movements or motor fluctuations. The goal is to …

This study tests an experimental pill, CVN424, in 330 people with Parkinson's disease who experience motor complications (wearing-off episodes). Participants take either a low or high dose of CVN424 or a placebo daily for 12 weeks. The main goal is to see if the drug reduces the …

This study looks at how deep brain stimulation (DBS) surgery helps people with Parkinson's disease move better and do daily activities. Researchers will measure walking speed, balance, muscle strength, and fear of falling in 40 patients before and after surgery. The goal is to se…

This expanded access program offers an experimental stem cell treatment to up to 11 people with Parkinson's disease who were not chosen for the main study. The treatment uses the patient's own fat-derived stem cells given through an IV. The goal is to see if it is safe and can he…

This early-stage trial tests whether transplanting lab-grown dopamine-producing cells into the brain is safe for people with Parkinson's disease. Eight participants with moderate Parkinson's will receive a single dose of these stem cells. The study focuses on safety and looks for…

This study tests a precise, non-invasive radiation treatment called frameless virtual cone radiosurgery for people with severe tremor from essential tremor or Parkinson's disease who cannot have deep brain stimulation. The goal is to reduce tremor and improve daily activities. Fo…

This study tests whether advanced brain imaging can help doctors fine-tune deep brain stimulation (DBS) for Parkinson's patients who already have DBS implants. The goal is to better control tremors while avoiding unwanted movements (dyskinesia). About 20 adults with Parkinson's a…

This study tests two types of memory training for people with Parkinson's disease who also have mild memory problems. 120 participants will be randomly assigned to one of two training programs and complete 8 sessions over 8 weeks. The goal is to see if these programs improve thei…

This study tests whether an 8-week program of high-intensity interval training in a pool can help people with Parkinson's disease improve their balance, physical function, and muscle health. About 56 adults aged 55 and older with mild to moderate Parkinson's will take part. The g…

This study tests whether doing physical therapy sessions at home via video call can improve balance and quality of life for people with multiple sclerosis or Parkinson's disease. Thirty-six participants will either receive 20 telerehabilitation sessions with a hospital physiother…

This study tests a specially designed drink for people with Parkinson's disease who often struggle with constipation. The drink contains extra fiber (inulin) and key vitamins that may improve gut health, nutrition, and overall well-being. About 56 adults with Parkinson's will tak…

This study looks at whether online support groups and remote doctor visits can improve quality of life for people with Parkinson's disease, Lewy body dementia, and similar conditions, as well as their caregivers. About 632 patients and their care partners are taking part. The goa…

This small study tests whether using inflatable cuffs on the legs during low-intensity stepping exercises can improve mobility and quality of life in people with advanced Parkinson's disease. Four participants will train twice a week for 8 weeks on a Nu-Step machine while wearing…

This study tests a brain-machine interface that can detect when a person with Parkinson's disease is about to freeze while walking and then stimulate the brain to prevent it. Ten people already scheduled for deep brain stimulation surgery will have extra sensors placed on the bra…

This study tests a special exercise program called TURN-IT designed to improve how people with Parkinson's disease turn, which is a common cause of falls. 55 participants with Parkinson's and a history of falls will either do the 6-week program or continue usual care. The goal is…

This study looks at whether a gentle brain stimulation technique called tDCS can improve depression and other non-motor symptoms in people with Parkinson's disease. About 80 participants will receive either real or fake tDCS for 30 minutes over 10 sessions. The goal is to see if …

This study tests a non-invasive device that stimulates a nerve in the ear to see if it can improve both movement and non-movement symptoms (like sleep and mood) in people with Parkinson's disease. Thirty adults will try three different stimulation patterns over several weeks. The…

This study tests whether a special light therapy device (Celeste) can improve quality of life and movement for people with Parkinson's disease. About 350 participants who are already on stable Parkinson's medications will use the light at home. The goal is to see if adding light …

This early-phase study tests whether using alternating-frequency deep brain stimulation (DBS) can improve walking and balance problems in people with Parkinson's disease. The study involves 12 participants who already have DBS implants. Researchers will measure changes in gait st…

This study tests a non-invasive brain stimulation technique called tTIS to see if it can improve movement problems in people with early to mid-stage Parkinson's disease. Researchers will compare two different brain targets (STN and GPi) in the same person to find which works bett…

This study tests whether a non-invasive brain stimulation technique (tDCS plus ultrasound) combined with physical therapy can improve balance problems in people with Parkinson's disease. Forty adults with Parkinson's who have balance issues will receive either real or fake stimul…

This study tests whether high-intensity interval training (HIIT) can improve cognitive function and quality of life in people with Parkinson's disease. Thirty participants will exercise in a supervised HIIT program, and their thinking skills and daily functioning will be measured…

This study is testing a set of five virtual reality games (exergames) in the metaverse designed to improve cognitive skills like memory, attention, and problem-solving in people with neurological disorders such as multiple sclerosis, Parkinson's disease, stroke, and traumatic bra…

This study tests a wearable device that delivers gentle vibrations to the skin to improve movement in people with Parkinson's disease. The treatment is meant to be used alongside regular medication and may help delay the need for higher doses. The study involves 30 participants a…

This small pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease who have memory or thinking problems. Ten participants will attend nine virtual coaching sessions and complete question…

This study tests whether taking melatonin (10 mg daily for 3 months) can improve symptoms and reduce cell damage in people with mild-to-moderate Parkinson's disease who are already taking levodopa. About 70 adults over age 45 will be randomly assigned to receive melatonin or a pl…

This study tests whether daily exposure to a flickering gamma light is safe and tolerable for people with Parkinson's disease who experience freezing of gait—a sudden feeling that their feet are glued to the floor. Twenty-four adults aged 50-80 will use the light at home for one …

This study looks at whether manual therapy (hands-on treatment by a therapist) can improve both movement and non-movement symptoms in people with Parkinson's disease. About 60 adults aged 40-75 will receive up to two therapy sessions per week for six weeks, in addition to their u…

This study tests an experimental drug called KDT-3594 in 150 people with advanced Parkinson's disease who still have movement problems despite taking levodopa. Participants take the drug or a placebo daily for 17 weeks. The goal is to see if KDT-3594 can improve motor function an…

This study tests whether a dietary fiber called resistant maltodextrin is safe and tolerable for people with Parkinson's disease. It also looks at how the fiber changes gut bacteria and whether it helps with movement and non-movement symptoms. Half of the 30 participants get the …

This study tests two different rehabilitation programs for people with Parkinson's disease who have trouble with balance and walking. One group does dual-task training (walking while doing a mental task) combined with watching and imagining movements, while the other group does d…

This study tests a new type of deep brain stimulation that adapts in real time to prevent freezing of gait in people with Parkinson's disease. Twenty participants will use wearable devices at home to track their walking. The goal is to see if this smart stimulation can reduce or …

This study explores whether low-intensity ultrasound can safely and precisely stimulate deep brain regions involved in Parkinson's disease and dystonia. Ten adults who already have deep brain stimulation (DBS) implants will receive ultrasound pulses while their DBS is off. Resear…

This study explores whether prism adaptation—using special glasses that shift vision—can improve emotional awareness and visual skills in people with Parkinson's disease. About 126 participants will undergo tests while researchers monitor brain activity with advanced imaging. The…

This study aims to understand how the brain regulates actions, especially in people with Parkinson's disease. Researchers will record brain activity from 125 patients during deep brain stimulation (DBS) surgery while they perform tasks involving decision-making, stopping, and swi…

This study is for people with Parkinson's disease who are getting deep brain stimulation (DBS). Researchers want to find brain signals that show when DBS might cause memory or thinking problems. By recording brain activity during surgery and later with the device on and off, they…

This study aims to see if a special camera (tethered capsule OCT) can safely take detailed pictures of the esophagus in people with Parkinson's disease. Researchers want to find out if there are visible changes in the gut nerves of 20 participants compared to people without Parki…

This study tests a computer program called AID-P that reads brain scans to help doctors tell the difference between Parkinson's disease and two similar conditions. About 315 adults with these diseases will get an MRI and a checkup, and the computer's diagnosis will be compared to…

This study looks at whether a device called GYKO can reliably measure balance in people with Parkinson's disease. About 25 participants will perform walking and turning tasks while wearing the sensor. Researchers will compare results from different raters and repeat tests a week …

This study looks at how the brain helps people with Parkinson's disease move more easily when they get certain cues, like visual or sound signals. Researchers will record brain activity during deep brain stimulation (DBS) surgery in 40 participants. The goal is to find brain sign…

This study aims to design and test rehabilitation strategies that combine physical and mental tasks (like walking while solving a puzzle) for people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. Researchers will work with 48 participants to see if these dua…

This study was designed to explore how a special meditation technique called orgasmic meditation (OM) affects brain function in people with Parkinson's disease. Researchers planned to use brain scans to measure dopamine and markers of inflammation. However, the study was withdraw…

This study looks at how changing the timing of deep brain stimulation (DBS) pulses affects movement symptoms and brain activity in people with Parkinson's disease, essential tremor, multiple sclerosis, or dystonia. Researchers will test different stimulation patterns in 180 parti…

This study tracks the exercise habits of 288 people with Parkinson's disease over one year using activity trackers and a phone app. Researchers compare three ways of giving exercise guidance: standard care, written advice from a neurologist, and physical therapy. The goal is to l…

This study aimed to learn how the brain controls speech in people with Parkinson's disease who are getting deep brain stimulation (DBS). Researchers planned to record brain activity during DBS surgery while participants performed speech tasks. The goal was to gather data that cou…

This study looks at whether an online educational session can help people with Parkinson's disease better understand deep brain stimulation (DBS) surgery. About 60 patients who are candidates for DBS will take part in a video call with experts and watch patient testimonials. The …

This study follows 60 Parkinson's disease patients who are scheduled for deep brain stimulation (DBS) surgery. Researchers will track their brain activity, movement, and thinking skills before, during, and after the procedure. The goal is to learn how DBS affects the brain over t…

This study follows 125 people with Parkinson's disease or related conditions over 2 years. Researchers use special brain scans to see how changes in a brain chemical called acetylcholine relate to walking difficulties and thinking skills. The goal is to better understand these pr…

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions, using yearly brain scans and other tests to see how the diseases change over time…

This study looks at whether small amounts of brain inflammation contribute to movement and thinking problems in people with Parkinson disease. Researchers will use a special PET scan with an experimental tracer to measure inflammation in the brain. The study includes 80 volunteer…

This study looks for biological signs of Parkinson's disease in blood, nasal brushings, and skin samples from 340 people, including those with Parkinson's, Alzheimer's, and healthy volunteers. Researchers aim to identify markers that reflect different disease processes, which cou…

This study tested whether a movement-recording watch, called the Personal KinetiGraph (PKG), helps doctors make better treatment decisions for people with Parkinson's disease. About 231 participants were split into two groups: one where doctors used the watch data during checkups…

This study looks at how things like social support, income, and lifestyle habits are linked to mental health and brain changes in people with conditions like depression, schizophrenia, Alzheimer's, and Parkinson's. About 1,310 European adults will complete surveys and optional br…

This study enrolls 500 adults with REM sleep behavior disorder (RBD) and healthy volunteers to track early signs of brain diseases like Parkinson's and Lewy body dementia. Participants undergo tests of thinking, movement, smell, and vision. The goal is to prepare for future clini…

This study aims to identify genetic, biochemical, and clinical factors linked to disease severity in people with Gaucher disease and other lysosomal storage disorders. Up to 1,000 participants, including patients, carriers, and healthy volunteers, will be evaluated annually. The …

This study aimed to understand how changes in blood pressure when standing up affect thinking abilities and brain blood flow in people with Parkinson's disease. Researchers planned to compare those with and without orthostatic hypotension (low blood pressure upon standing) using …

This early-phase study tests whether a new type of PET scan can measure inflammation in the brains of people with Parkinson's disease. Eleven participants, including both Parkinson's patients and healthy volunteers, will receive an imaging drug called 18F-NOS to see if it can det…

This early-phase study tests a smart brain stimulator that adjusts stimulation in real time to improve walking in people with Parkinson's disease. Ten participants will have their brain activity recorded during walking tasks to find the best way to deliver personalized stimulatio…

This study asks 1,000 people with neurological diseases (like Alzheimer's or Parkinson's) and their caregivers to share their experiences using a head device called MemorEM. The goal is to learn how to improve the device's design and make it easier to use in future studies. No tr…

This study is testing how well wearable devices like mobile EEG headsets and smartwatches can measure sleep problems and symptoms in people with Parkinson's disease. Researchers want to see if these tools are easy to use and if they can help discover new biological markers. About…

This study follows 96 people with moderate Parkinson's disease to see how their symptoms change over 3 to 24 months. Participants continue their usual medications, and doctors may adjust them for better symptom control. The study does not test a new treatment but aims to better u…

This study follows 200 people with Parkinson's disease or multiple sclerosis for one year. Participants use a smartphone app to track their daily steps and exercise. The goal is to learn how physical activity and confidence in exercising change over time, without providing any tr…

This study collects movement data from 250 people with stroke, Parkinson's, or leg amputations using wearable sensors and video. The goal is to create a database that researchers can use to better understand movement and rehabilitation. Participants range from newborns to 99 year…

This study looks at how certain cues, like visual or auditory signals, help people with Parkinson's disease move more easily. Researchers will use EEG and MRI to watch brain activity while participants perform movement tasks. The goal is to find brain patterns that could lead to …

This early-phase study uses advanced MRI to measure how well the brain clears waste fluids in people with Parkinson's disease compared to healthy volunteers. The goal is to develop better imaging methods to understand the brain's lymphatic system, which may play a role in Parkins…

This study is analyzing blood samples from 1,799 people with brain diseases (like Alzheimer's, dementia, depression, and schizophrenia) and healthy volunteers. Researchers want to see if certain substances in the blood can help doctors diagnose these conditions more accurately. T…

This study looks at whether a small skin sample can measure a protein called phosphorylated alpha-synuclein, which is linked to Parkinson's disease and REM sleep behavior disorder. Researchers will follow 100 adults aged 50 to 85 for 18 months to see if changes in this protein ma…