Scientists peek at brain's plumbing in Parkinson's patients
NCT ID NCT04768101
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study uses advanced MRI to visualize the brain's lymphatic system, which may help clear waste linked to Parkinson's and other brain diseases. Researchers will compare images from 140 people with and without Parkinson's to see if this system works differently in the disease. The goal is to develop better imaging tools, not to test a treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
-
About 140 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Apr 2020
- Expected to finish
-
Dec 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
55 to 80 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * diagnosis of Parkinson's Disease or controls * willing to participate in PET and MRI imaging Exclusion Criteria: * recent stimulant use * unstable diabetes * prior stroke * claustrophobia * prior cancer treatment with chemotherapy * history of traumatic brain injury * any unstable medical condition
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Parkinson disease are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Vanderbilt University Medical Center
Nashville, Tennessee, 37212, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a massive data registry crack the code of Parkinson's and related brain diseases?
- Reading the Brain's signals to predict who benefits from deep brain stimulation
- Giving Parkinson's patients a say may boost their Brain's ability to learn movement
- Brain scans probe why some Parkinson's patients freeze Mid-Step
- Can tango rewire the brain? dance program tested for Parkinson's and dementia
- Can a workout after walking practice help Parkinson's patients learn better?