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Tiny study tests blood flow cuffs and stepping machine for advanced Parkinson's

NCT ID NCT07221994

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This small pilot study tested whether using inflatable cuffs on the legs (blood flow restriction) during low-intensity stepping exercise could safely improve mobility and quality of life in people with advanced Parkinson's disease. Three participants exercised twice a week for 8 weeks on a Nu-Step machine while wearing the cuffs. The main goal was to check for side effects, with secondary goals of measuring motor symptoms and functional mobility.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Blood flow restriction (BFR) device and aerobic exercise via recumbent stepping
What this could lead to
If it works, this could offer a gentle exercise option to help people with advanced Parkinson's improve mobility and daily function.
What could go wrong
This is a very small pilot study (only 3 participants) with no control group, so results may not apply to others. The main goal was safety, not proof of effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

3 people

The number who actually took part.

Started

Nov 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18+ 2. People with advanced Parkinson's disease. "Advanced PD" will include signs of progressed disease including orthostatic hypotension and/or motor issues reflective of postural instability and/or mild-moderate bilateral symptoms (confirmed visually in clinic or home by a medical provider such as an MD/PT and/or documented in the medical record. 3. Ability of individual or legal guardian/representative to understand a written informed consent document, and the willingness to sign it. 4. Diagnosis of idiopathic Parkinson's disease (self-reported okay, documented preferred) 5. Independent ambulation (≥10m with or without an assistive device) 6. Commitment to participate in the exercise intervention as outlined 7. Score of ≥21 on the Montreal Cognitive Assessment (MoCA) Exclusion Criteria: 1. History of cardiovascular disease, uncontrolled hypertension (blood pressure ≥140/90 mmHg), deep-vein thrombosis, varicose veins, or rhabdomyolysis which a patient's primary physician determines would preclude them from safe study participation. 2. Ankle branchial index ≤ 0.9 or \> 1.3 3. History of or comorbid conditions spanning cardiovascular, neurological, or orthopedic injuries which may prevent for the safe administration of the intervention (a healthcare provider's clearance or guidance will be obtained in these situations to ensure appropriateness), including current medications. 4. History of uncontrolled diabetes, BMI \> 40, or severe cognitive impairment (as measured by MoCA \<21) 5. Atypical PD diagnoses or ON PD-medication worsening of motor symptoms 6. Absolute contraindications to exercise as per the American College of Sports Medicine (uncontrolled arrhythmias, third-degree heart block, recent electrocardiogram (EKG) changes, unstable angina, acute myocardial infarction, or acute congestive heart failure)

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Conditions

The condition(s) this trial relates to.

Motor Activity Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • UCSF Health & Wellness Center (UCSF Mission Bay)

    San Francisco, California, 94158, United States

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