PARKINSON DISEASE

This early-phase study tested a vaccine called UB-312 in 8 people with Parkinson's disease or multiple system atrophy. The goal was to see if the vaccine is safe and helps the body make antibodies against a harmful protein linked to these brain diseases. The study focused on safe…

This study tested a new drug called TJ0113 in 149 people with early-stage Parkinson's disease. Half received the drug and half received a placebo (a dummy pill) for 12 weeks. The main goal was to see if TJ0113 improved motor symptoms (like movement and coordination) compared to p…

This study tested the safety of using focused ultrasound to treat movement problems in people with Parkinson's disease. Six participants who already had one side treated received a second treatment on the other side of the brain. The goal was to see if the procedure is safe and i…

This study tested an experimental drug called vutiglabridin in 99 people with early Parkinson's disease. Participants took either the drug or a placebo daily for 24 weeks. Researchers measured changes in movement, daily function, and safety to see if the drug could help control t…

This study follows one Parkinson's patient who has been receiving A-dopamine directly into the brain for years. The goal is to track safety and gradually reduce the dose to avoid sudden停药, switching to an alternative treatment if needed. It focuses on managing the transition rath…

This small pilot study tested a new way to get the drug Cerezyme into the brains of 4 people with Parkinson's disease. Doctors used MRI-guided focused ultrasound to temporarily open the blood-brain barrier, allowing the drug to reach a targeted area. The main goal was to see if t…

This study tested whether a daily supplement called nicotinamide riboside (a form of vitamin B3) can slow the progression of early Parkinson's disease. 410 people with early-stage Parkinson's took either the supplement or a placebo for 52 weeks. The main goal was to see if the su…

This study tested whether taking citalopram for 26 months could slow the buildup of harmful amyloid plaques in a brain area important for vision and thinking in people with Parkinson's disease. 58 older adults with Parkinson's took either citalopram or a placebo. Researchers used…

This study tested a new way to treat severe hand tremors in people with Parkinson's disease. Ten adults received a focused ultrasound treatment that targets a small area in the brain to stop the shaking. The goal was to see if it is safe and if it can reduce tremors without needi…

This study tested a new way to perform deep brain stimulation (DBS) for Parkinson's disease. Instead of the usual awake surgery with micro-electrode recordings, the new method uses MRI-based targeting under general anesthesia. 128 patients were randomly assigned to one of the two…

This study looked at whether nutritional supplements, specifically N-acetyl cysteine (NAC), could support brain function in people with Parkinson's disease. 51 participants were randomly assigned to receive NAC (orally and intravenously), standard care, or other oral supplements.…

This study tested a new approach for people with advanced Parkinson's disease who have severe movement problems despite standard treatments. A pump placed in the brain delivered a special form of dopamine continuously, compared to taking many oral doses each day. The goal was to …

This study tested whether lixisenatide, a drug used for diabetes, could slow the worsening of movement problems in people with early Parkinson's disease. 156 participants received either the drug or a placebo alongside their usual Parkinson's medications. The goal was to see if t…

This phase 2 study tested whether a person's own stem cells (called HB-adMSCs) could help control Parkinson's disease. Twenty-four adults with early to moderate Parkinson's received either stem cells or a placebo over 32 weeks. The main goal was to see if the treatment improved d…

This study tested whether a drug called rivastigmine, already used for memory problems in Parkinson's, can also prevent falls. 600 people with Parkinson's who had fallen in the past year took either the drug or a placebo patch for 12 months. The goal was to see if the drug could …

This study tested the long-term safety and effectiveness of tavapadon, an experimental drug for Parkinson's disease. Nearly 1,000 participants took flexible doses of the medication for 58 weeks. Researchers monitored side effects, symptom changes, and quality of life to see if th…

This study tested whether a drug called deferiprone, which removes extra iron from the body, could slow down Parkinson's disease. 372 adults with early Parkinson's who were not yet on other treatments took either deferiprone or a placebo for 9 months. The goal was to see if the d…

This study tested whether metformin, a common diabetes drug, can help people with Parkinson's disease. Researchers gave metformin to 60 adults with Parkinson's who were already taking levodopa. The goal was to see if metformin could improve movement and daily function, and also c…

This early-stage trial tested a natural brain chemical called allopregnanolone in 10 people with Parkinson's disease. Participants received weekly infusions for 12 weeks to see if the treatment is safe and well-tolerated, and to check for any signs of improvement on brain scans a…

This study tested a treatment called ExAblate subthalomotomy for people with Parkinson's disease whose motor symptoms (like tremor and stiffness) were not well controlled on one side of the body. The treatment uses focused ultrasound to target a small area in the brain. 36 partic…

This study tested whether two types of diabetes medications (DPP4 and SGLT2 inhibitors) are safe and can improve movement and thinking in people with Parkinson's disease or Lewy body dementia. 18 adults with these conditions and mild blood sugar issues took the drugs for 4 weeks.…

This study tested two different spots in the brain for deep brain stimulation to control tremors in people with Parkinson's disease. 27 participants received stimulation in both the posterior subthalamic area and the subthalamic nucleus to see which worked better. The goal was to…

This early-stage study tested whether injecting special human nerve stem cells into the brain is safe for people with Parkinson's disease. Twelve patients received the cells directly into areas of the brain affected by Parkinson's. The main goal was to check for side effects, not…

This early-phase study tested whether a drug called Leukine (sargramostim) is safe for people with Parkinson's disease when taken for 36 months. Seven participants received a weight-based dose 5 days a week. Researchers monitored side effects, immune system changes, and movement …

This study tested whether amantadine, given early in Parkinson's disease, can prevent or delay the involuntary movements (dyskinesia) caused by the standard drug L-DOPA. About 210 people with early-stage Parkinson's who had been on L-DOPA for less than a year took either amantadi…

This study tested a new way to deliver deep brain stimulation (DBS) for Parkinson's disease. The adaptive DBS (aDBS) automatically adjusts stimulation based on brain signals, while standard DBS gives constant stimulation. Researchers wanted to see if aDBS uses less total electric…

This study tested whether a single type of donated stem cell (HB-adMSCs) could help people with Parkinson's disease. 60 adults aged 45-80 received either the stem cells or a placebo. The goal was to see if the treatment improved movement and daily living skills, and to check for …

This study created and tested a simple questionnaire called the 3PDQ to help doctors diagnose pain that is directly caused by Parkinson's disease. Researchers worked with 227 French-speaking Parkinson's patients who had moderate to severe chronic pain. The questionnaire asks abou…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. The goal was to help doctors and nurses better understand a patient's fall risk and car…

This study tested whether a new type of PET scan can tell the difference between Parkinson's disease and essential tremor as well as the current standard SPECT scan. 152 adults with either condition received both scans. The goal was to see if the newer method is at least as accur…

This study tested a smartphone-based wearable system that gives real-time feedback to people with Parkinson's disease while they do balance exercises at home. Nine participants aged 50-75 used the system or followed a paper-based routine. The goal was to see if the smartphone gui…

This study looked at whether donepezil, a drug that increases a brain chemical called acetylcholine, can improve walking and balance in people with Parkinson's disease. Six participants took the drug for 12 weeks. The goal was to see if changes in a specific brain area relate to …

This study tested a new type of deep brain stimulation (DBS) that automatically adjusts its settings to help people with Parkinson's disease who have trouble walking or experience freezing of gait. Twelve participants were involved, and the system used brain signals and movement …

This study looked at whether adding Baduanjin, a gentle mind-body exercise, to standard physical therapy helps older adults with Parkinson's disease. 27 people living in a nursing home took part, with one group doing Baduanjin plus standard therapy and the other doing only standa…

This study tested whether training on a split-belt treadmill (where each leg moves at a different speed) can reduce freezing of gait during turning in people with Parkinson's disease. 26 participants completed a 4-week program that included practicing everyday turning scenarios. …

This study tested an experimental drug called suvecaltamide in 169 adults with Parkinson's disease who still had moderate to severe shaking (tremor) despite their usual medications. The goal was to see if the drug could reduce tremor and improve daily activities like eating and d…

This study looked at whether combining exercise training with a ketone ester drink could improve muscle endurance and heart fitness in people with Parkinson's disease. Nineteen participants completed cycling tests before and after the program. The goal was to see if this combinat…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve balance and walking ability in people with Parkinson's disease. Twenty-one participants received both low- and high-frequency stimulation in…

This study explored whether smart electric vehicles can detect walking problems and help improve balance in people with Parkinson's disease or dementia. 120 participants aged 60-85 with mild to moderate walking issues took part. The main goal was to see if the vehicles could assi…

This study tested a 12-week exercise program set to music for 108 adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants were split into two groups: one did the music-based exercise, the other waited. The goal was to see if this fu…

This study tested whether specially designed virtual reality exercises could improve arm and hand function in people with Parkinson's disease. 44 participants completed the program, which focused on matching arm positions. The goal was to see if this approach could help with dail…

This study tested whether a walker that provides visual and auditory cues can improve walking in people with Parkinson's disease who experience freezing of gait. Thirty participants walked with and without the cueing walker. Researchers measured walking speed, balance, and abilit…

This study tested a fun, video-game-based exercise program to help people with Parkinson's disease who have trouble walking and balancing. Twenty-five participants played specially designed games to improve their movement. The goal was to see if this approach could make everyday …

This study tested whether adding arm and hand exercises to leg exercises during high-intensity circuit training helps people with Parkinson's disease more than leg exercises alone. Sixty-four participants completed 8 exercise classes. Researchers measured reaction time, balance, …

This study tested whether infusing tiny bubbles of oxyhydrogen gas could help people with Parkinsonism. Researchers measured changes in disease severity, thinking ability, and quality of life in 35 adults aged 18-70. The treatment was given as an add-on to regular care, not as a …

This study tested whether low-frequency magnetic stimulation (rTMS) on the cerebellum can help people with Parkinson's disease. Forty adults with mild to moderate Parkinson's received the treatment while continuing their usual medications. Researchers measured changes in movement…

This study tested a gait re-education program using a special square treadmill (Tapiz Fisior) in 52 people with mild to moderate Parkinson's disease. Participants were split into two groups: one received the treadmill program plus standard physiotherapy, the other received standa…

This study tested a non-invasive magnetic stimulation device placed on the back to see if it could improve walking problems in people with Parkinson's disease who already have a brain pacemaker (deep brain stimulation). 42 adults with Parkinson's and walking difficulties took par…

This study tested whether cognitive rehabilitation using immersive virtual reality or computer-based brain games could improve mild thinking problems in people with Parkinson's or Huntington's disease better than music therapy. 64 participants completed the trial, which compared …

This study tested whether adding action observation therapy (watching movements) to standard physical therapy helps people with Parkinson's disease walk better and reduce freezing of gait. 42 participants aged 50-80 with mild to moderate Parkinson's took part. The approach aims t…

This small pilot study tested whether stimulating two brain areas at once could help Parkinson's patients who still have freezing of gait despite standard deep brain stimulation. Ten participants received combined stimulation of the substantia nigra pars reticulata and subthalami…

This study tested whether Ericksonian hypnosis can reduce chronic pain in people with Parkinson's disease. 33 adults were split into two groups: one received hypnosis sessions for 2 months, the other got usual care. Researchers measured pain intensity and other pain-related score…

This study tested a wearable device called PDVibe2 that delivers gentle vibrations to improve walking and balance in people with Parkinson's disease. 12 participants completed the trial, which measured changes in gait and movement symptoms. The goal was to see if the device is sa…

This study tested a new treatment for walking problems in Parkinson's disease. It combined a non-invasive spinal stimulation technique (repetitive transspinal magnetic stimulation) with treadmill training. 76 people with moderate Parkinson's participated. The goal was to see if t…

This study looked at vision problems in people with Parkinson's disease and tested simple eye exercises to see if they could help. Researchers compared 160 participants—some with Parkinson's and some healthy—using non-invasive vision tests. In a second phase, a group of Parkinson…

This study tested a video-based exercise program for the arms and shoulders in 30 people with Parkinson's disease who also had a stooped posture. Participants used a motion-sensing system to play guided games aimed at improving joint movement, balance, and daily function. The goa…

This study tested whether people with Parkinson's disease can use augmented reality glasses (called Cue X) to do daily rehabilitation exercises at home. Thirty participants wore the glasses for 6 weeks, guided remotely by a physiotherapist. The goal was to see if this technology …

This study tested an experimental drug called UCB0022 in 207 people with advanced Parkinson's disease. The goal was to see if adding UCB0022 to their usual treatment could reduce the daily hours when Parkinson's symptoms return (OFF time). Participants were randomly assigned to r…

This study looked at whether adding a foot stimulation device (AMPS) to regular exercise helps people with Parkinson's disease. 40 participants were split into two groups: one got real stimulation plus exercise, the other got a fake device plus exercise. The goal was to see if th…

This study looked at two common treatments for a condition where blood pressure drops sharply when standing up (orthostatic hypotension) in people with autonomic failure. The treatments were a medication called midodrine and a tight abdominal binder. Researchers measured heart he…

This study looked at whether a non-invasive nerve stimulation (like a gentle pulse on the ear) combined with physical therapy could help people with Parkinson's disease move better and feel better. Twenty-five adults with mild-to-moderate Parkinson's took part. The goal was to se…

This early study tested a drug called SAGE-718 in 18 people with Parkinson's disease who also have mild problems with memory and thinking. The main goal was to see if the drug is safe and tolerable. Researchers also looked at whether it helped with thinking, mood, and movement. T…

This study tested a new medication called tavapadon in 304 people with early Parkinson's disease. The goal was to see if it could improve movement and daily activities better than a placebo over 27 weeks. Tavapadon is designed to help control symptoms, not cure the disease.

This study looked at whether Argentine tango classes can improve thinking, mood, and movement in people with mild to moderate Parkinson's disease. 45 participants took part in the dance program. Researchers measured changes in memory, attention, walking, balance, and emotional we…

This small study tested whether people with Parkinson's disease can safely use a brain-stimulation device called tDCS at home. Six participants, aged 40 to 70, used the device for 20 minutes each day for a week, with video call support. The main goal was to see if it was practica…

This study looked at whether taking weekly improvisational dance classes for 12 weeks could improve thinking skills and daily life abilities in people with Parkinson's disease. Twenty participants were randomly assigned to either start dance right away or wait. Researchers measur…

This study tested a safe, self-administered brain stimulation technique (transcranial direct current stimulation) to see if it could improve walking in people with Parkinson's disease. Twenty-four participants used the device at home while performing walking tasks, both alone and…

This study tested whether online dance classes or online therapeutic exercises, both with music, could improve quality of life and well-being in people with Parkinson's disease. Forty participants were randomly assigned to one of the two groups. The goal was to see if these socia…

This study looked at whether a newer type of deep brain stimulation (called directional stimulation) can help improve walking and balance problems in people with Parkinson's disease. Nineteen patients who were already eligible for standard deep brain stimulation took part. Resear…

This study tested whether training with rhythmic sounds (like a beat) can help people with Parkinson's disease move their arms better. 38 participants completed a 21-day program, and those who used rhythmic sounds showed lasting improvements in hand dexterity and movement speed o…

This study tested a program that teaches people with early-stage Parkinson's disease how to add more physical activity into their daily lives. 89 participants either received the program or were put on a waiting list. The goal was to see if the program increased their moderate-to…

This study tested whether a program pairing older Latino adults with Parkinson's disease with a peer partner could help them become more physically active. Ten participants wore activity monitors, watched educational videos, met weekly with a partner online, and joined virtual ex…

This study tested whether pimavanserin, a drug already approved for Parkinson's psychosis, can reduce impulse control disorders like compulsive gambling or eating. 117 adults with Parkinson's and moderate-to-severe impulse control problems took the drug or a placebo for 8 weeks. …

This study tested an 8-session program called SMART-PD that teaches relaxation and coping skills to people with Parkinson's disease and their caregivers. The goal was to see if the program is practical and helpful for reducing stress, anxiety, and depression. 49 participants took…

This study tested whether bright light therapy can improve daytime sleepiness and mood in people with Parkinson's disease. 69 participants were randomly assigned to bright light, a placebo light, or an active control. The goal was to see if light exposure could ease these common …

This study tested whether a daily insulin nasal spray is safe for people with Parkinson's disease and whether it might help with thinking, mood, and movement. Thirty-one participants used the spray for three weeks. The main goal was to check for side effects like low blood sugar …

This study tested whether doing exercises that combine physical movement with mental tasks (like walking while counting) can improve quality of life and balance in people with Parkinson's disease. Thirty participants completed the program remotely via video calls. The goal was to…

This early-stage study tested a new drug called Lu AF28996 in 57 people with Parkinson's disease. The main goal was to see if the drug is safe and how the body processes it. Researchers measured side effects and drug levels in the blood. This is a first step to see if the drug mi…

This study tested whether music therapy could prevent hospital-acquired delirium (sudden confusion) in patients with Parkinson's disease or Lewy body dementia. Thirty hospitalized adults were randomly assigned to music therapy, self-directed music listening, or standard care. The…

This study tested a new drug called IkT-148009 in 137 adults with Parkinson's disease who were not taking any other Parkinson's medications. The goal was to see if the drug is safe and tolerable, and to measure its effects on movement and daily living symptoms over 12 weeks. Part…

This study tested two drugs, oxycodone and levodopa, against a placebo to see if they could reduce nerve pain caused by Parkinson's disease. 67 people with Parkinson's and chronic nerve pain took one of the three treatments for 10 weeks, in addition to their usual Parkinson's med…

This study tested two rhythm-based walking exercises in 74 people with mild-to-moderate Parkinson's disease. Participants either walked to music or while singing for 12 weeks. Researchers measured walking speed and brain activity changes to see which method worked better.

This study tested different doses of light therapy to see which works best for improving sleep in people with Parkinson's disease. 203 participants received either bright white or dim red light at different times of day. The goal was to find the most effective way to ease sleep p…

This study compared virtual reality-assisted walking and balance exercises to standard physical therapy in 20 people with Parkinson's disease. Participants were aged 60-80 and had mild to moderate symptoms. The goal was to see if the high-tech approach improved gait and balance m…

This study looked at whether a modified Mediterranean-ketogenic diet is safe for the gut microbiome in people with Parkinson's disease. Fifty-two adults with mild to moderate Parkinson's followed the diet for 8 weeks. Researchers measured gut inflammation and other markers to see…

This study tested an experimental drug called SAGE-718 to see if it could improve thinking and memory in people with Parkinson's disease who have mild cognitive impairment. 86 participants took either the drug or a placebo. The main goal was to measure changes in processing speed…

This study tested if a gentle, non-invasive brain stimulation called tACS could help people with Parkinson's disease think more clearly and speak more easily. 28 adults received either real or fake (placebo) stimulation for 20 minutes daily over two weeks. Researchers measured ch…

This small pilot study tested whether a mindfulness meditation program could reduce embarrassment from tremor in people with Parkinson's disease. Twenty-one participants were split into two groups: one received meditation training, the other did not. Researchers used questionnair…

This study tested a new, non-invasive technique called Low-Intensity Focused Ultrasound Pulsation (LIFUP) to see if it can improve motor symptoms in people with Parkinson's disease. 31 participants received the ultrasound while their brain activity was monitored with an MRI. The …

This study tested whether a weekly hula dance program is practical and helpful for people with Parkinson's disease. Fifteen participants took hula classes for three months, and researchers measured their balance, movement, and quality of life before and after. The goal was to see…

This study tested whether spinal cord stimulation (SCS) can help Parkinson's patients who experience freezing of gait (sudden inability to walk) that doesn't improve with medication. Ten adults with Parkinson's received SCS to see if it safely reduces freezing episodes and improv…

This study looked at whether a 6-month in-home cycling program, combined with social support and health coaching, could improve daily activities and sleep for people with Parkinson's disease. Fourteen participants used a stationary bike at home and received guidance from a health…

This study tested if a single session of automated foot stimulation could temporarily improve movement, balance, and heart function in 40 people with mild to moderate Parkinson's disease. Participants received a non-invasive foot massage-like therapy, and researchers measured cha…

This study looked at whether group drum classes could help people with Parkinson's or Huntington's disease feel better and move easier. Eighteen adults aged 18-89 took drum lessons twice a week for 12 weeks. Researchers checked their hand movement, mood, and overall well-being be…

This study looked at how Parkinson's disease affects walking and the ability to react to balance challenges. Twelve people with mild to moderate Parkinson's took part in protective step training, which involved responding to sudden movements. The goal was to see if short-term tra…

This study used virtual reality to create situations that cause freezing of gait in people with Parkinson's disease who have a deep brain stimulator (DBS). While walking in VR, brain signals were recorded from the DBS device to understand what happens in the brain during freezing…

This study tested a wearable device called the Parkinson Holter that tracks movement problems in people with moderate to severe Parkinson's disease. The goal was to see if giving doctors detailed, real-world data from the device helps them adjust medication better than relying on…

This study used brain scans to understand how Parkinson's disease changes the brain over time. Researchers compared people with definite or possible Parkinson's to healthy volunteers. Participants had up to 6 visits over 9 years for MRI scans and symptom checks. The goal was to f…

This study looked at whether people with Parkinson's disease learn better when feedback on their answers is delayed by 25 minutes instead of given right away. Researchers think delayed feedback may work through brain pathways not damaged by Parkinson's. Forty participants without…

This study tested whether a mobile app that gives visual feedback and motivational reminders can help older adults (60+) with conditions like COPD, heart failure, or Parkinson's spend more time out of bed while in the hospital and for three months after going home. Researchers tr…

This study looked at whether inner ear problems cause poor balance in people with Parkinson's disease. Researchers tested a small device that stimulates the inner ear to see if it could improve walking and balance. 72 people with Parkinson's took part in clinical tests and brain …

This study looked at how people with Parkinson's disease learn and remember fine motor tasks, like writing. Researchers compared simple practice versus practice combined with a second task (dual-tasking) to see which method leads to better long-term retention. Using brain scans a…

This study looked at how a single session of exercise changes brain activity in people with Parkinson's disease who have a brain implant (DBS). Twenty-five participants completed thinking and movement tests before and after exercise. The goal was to find brain signals linked to b…

This study translated a short, 7-question survey called PDQoL7 into Turkish and checked if it accurately measures quality of life in people with Parkinson's disease. Researchers tested the questionnaire with 129 Turkish-speaking Parkinson's patients. The goal was to give doctors …

This study looked at 158 people with Parkinson's disease to see if different thinking (cognitive) patterns are linked to specific brain changes. Researchers used brain scans to measure gray matter density and identify distinct cognitive profiles. The goal was to better understand…

This study looked at how Parkinson's disease changes the thickness of a specific back tissue, trunk flexibility, and hand dexterity. Researchers compared 80 people aged 50-80 with Parkinson's to healthy individuals of similar age. They used ultrasound, movement tests, and a pegbo…

This study looked at how people with dystonia, essential tremor, or Parkinson's disease adapt their eye movements compared to healthy volunteers. Researchers used a special eye-tracking task to measure changes in saccade (quick eye movement) accuracy. The goal was to better under…

This study looked at why people with Parkinson's disease often feel very tired. Researchers measured fatigue, mood, sleep, and physical function in 129 adults with stable Parkinson's. The goal was to better understand what contributes to this common and disabling symptom.

This study tested how accurately a robot system called Neurolocate can guide deep brain stimulation surgery. 18 patients with Parkinson's disease, dystonia, or tremor took part. The goal was to see if the robot hits its target as planned, which could make surgery faster and more …

This study looked at how a gentle electrical current applied to the scalp (tDCS) changes brain activity in people with Parkinson's disease. Researchers measured brain signals during a reaching task in 20 participants. The goal was to learn exactly how tDCS works, which could lead…

This study tested whether ultrasound imaging can detect and model hand tremors in people with Parkinson's disease or essential tremor. Researchers used the ultrasound data to design electrical stimulation that might suppress tremors during grasping. The study involved 12 adults a…

This study aimed to learn more about why people have tremors by observing brain activity and movement in 85 adults with conditions like Parkinson's disease, essential tremor, or dystonia, as well as healthy volunteers. Participants completed tasks while researchers used tools lik…

This study aims to adapt the Dresden Falls Questionnaire (DREFAQ) for Turkish Parkinson's patients and check if it is a reliable and valid tool. Researchers will ask 64 patients to fill out the questionnaire along with other scales during rehab sessions. The goal is to help docto…

This study used PET scans to watch brain activity while people performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to learn how the frontal lobe works during thinking and how certain drugs might affect it.

This study looked at why people with Parkinson's disease often gain weight after getting deep brain stimulation (a treatment that uses electrical pulses in the brain). Researchers measured how much energy 20 patients burned at rest and after eating, both with and without their re…

This study looked at how common muscle loss and weakness are in people with Parkinson's disease compared to healthy adults. Researchers measured muscle thickness, grip strength, and physical performance in 43 Parkinson's patients and 22 healthy volunteers. The goal was to better …

This study investigates why humans swing their arms when walking, a common but poorly understood movement. Researchers observed 25 people, including healthy volunteers and those with conditions like multiple sclerosis or stroke, walking on a special treadmill. The goal is to lear…

This study used PET and MRI scans to compare how the brain uses dopamine in people with Gaucher disease or Parkinson's, their family members, and healthy volunteers. The goal was to find early brain changes linked to a specific gene mutation. About 64 adults aged 21 and older too…

This study looked at 733 people with Parkinson's disease to see if certain genetic changes in the AQP4 gene are linked to worse motor, cognitive, and sleep symptoms. Researchers measured these gene variations and compared them to symptom severity. The goal was to better understan…

This study looked for early biological signs (biomarkers) of Parkinson disease in 89 people who had certain risk factors, like a family history or loss of smell. Participants underwent a series of tests, including brain scans, blood draws, and spinal taps, and were followed for s…

This completed study looked at brain activity in 87 people with and without Parkinson disease while they moved their legs. Researchers also tested how two types of partnered dance might change brain signals. The goal was to understand how the brain controls movement, not to test …

This early-stage study tested a new drug called PDM608 in 64 healthy adults to see if it is safe and how the body processes it. The goal was to check for side effects and measure drug levels in the blood. This is a first step before testing the drug in people with Parkinson's dis…

This study watched and interviewed 22 people with Parkinson's disease who have trouble swallowing and need help eating, along with their caregivers. The goal was to describe the verbal and non-verbal strategies used to make meals safer and more pleasant. No new treatments were te…

This study tested whether artificial intelligence (AI) could predict fall risk in 30 people with Parkinson's disease. Participants performed walking tests, both alone and while doing a thinking task (dual-task), to see which better predicted falls. The goal was to create a tool t…

This study tested a new questionnaire (NF-scale) designed to quickly assess mood and thinking changes that happen when Parkinson's medication wears off. Researchers worked with 130 French-speaking adults who have Parkinson's and experience motor fluctuations. The goal was to conf…

This study tested new ways of delivering deep brain stimulation (DBS) to people with Parkinson's disease. Instead of constant stimulation, researchers tried intermittent patterns to see if they could control movement symptoms while reducing effects on thinking and memory. Sixteen…

This completed online study looked at how spending time in nature (like parks, gardens, or beaches) might improve mood and thinking in 97 adults aged 40 and older, both with and without Parkinson's disease. Participants filled out surveys about their connection to nature, mood, s…

This study tested a watch-like device called the Personal KinetiGraph (PKG) to see if it can accurately measure movement problems in people with Parkinson's disease. Nineteen participants, including both people with movement disorders and healthy volunteers, wore the PKG watch wh…

This study followed 83 people with Parkinson's disease and related conditions, along with healthy volunteers, to see if walking patterns measured at home with special insoles can track disease progression. Participants wore the insoles for 10 days at a time, and their walking spe…

This study followed 29 people with Parkinson's disease to observe speech and movement issues that don't respond to standard medication. Participants underwent brain scans, breathing tests, and thinking assessments. The goal was to better understand these non-dopaminergic symptoms…

This study aimed to create a better way to help older adults with muscle, bone, or nerve problems who are at risk of falling. Researchers worked with 11 seniors to understand their health profiles, test their balance and walking, and try a special exercise program called OTAGO. T…

This study used MRI scans to look at brain activity in people with Parkinson's disease while they moved their arms and legs. The goal was to better understand why movement problems happen. 40 people took part, including those with Parkinson's and healthy older adults.

This study looked at whether a workshop about Parkinson's medications can change how patients think about their drugs. 24 people with Parkinson's took part, and researchers measured their beliefs about medicines before and after the workshop. The goal was to see if education help…

This study looked at why Hispanic/Latino people with Parkinson's disease may have more thinking and memory problems than others. Researchers focused on heart-related risks like diabetes, high blood pressure, and obesity. They tested 40 adults in California and North Carolina to s…

This study used brain scans to compare a specific serotonin receptor (5-HT4) in 40 people with mild-to-moderate Parkinson's disease versus healthy volunteers of similar age. The goal was to see how these receptors relate to movement, thinking, and mood symptoms. No treatment or d…

This study looked at how deep brain stimulation (DBS) affects brain networks in people with Parkinson's disease. Researchers used a special type of brain scan called HD-DOT to measure brain activity in 49 participants, including those with and without Parkinson's. The goal was to…

This study tested whether wearable sensors can reliably measure movement issues in people with Parkinson's disease. Fifty participants wore sensors while performing tasks like finger tapping and walking. The goal was to see if these sensors could provide accurate, objective data …

This study looked at two ways to guide brain surgery for Parkinson's disease. The goal was to see if using a special scanner (O-ARM) during surgery is better than the usual method of taking images beforehand. Twenty-four patients took part, and the main focus was on how accuratel…

This study looked at whether a probiotic called Bacillus subtilis can change certain markers in the gut and blood of people with Parkinson's disease. 26 participants took the probiotic or a placebo to see how it affected their gut bacteria, blood fats, inflammation, and other hea…

This study looked at 15 people with Parkinson's disease who have a deep brain stimulation device. Researchers used a special brain imaging technique to measure changes in brain blood flow while participants did a hand movement task and an impulse control task, both with the stimu…

This study looked at whether it's possible to use wearable motion sensors and brain scans to track Parkinson's disease symptoms when patients stop their medication for a week. Twenty people with early-stage Parkinson's took part. The goal was to see if these tools could help desi…

This study looked at 70 Parkinson's patients to see if personality traits and social factors could predict how much their quality of life improves after starting a continuous apomorphine infusion. Researchers measured personality, coping styles, and social support before treatmen…

This study aimed to identify genes and environmental factors that increase the risk of developing Parkinson's disease. Researchers compared DNA and lifestyle data from over 2,200 people, including those with Parkinson's, related brain diseases, and healthy volunteers. The goal wa…

This study looked at 300 people with early-stage Parkinson's disease to see if simple eye-tracking tests could measure how the disease changes over time. Researchers compared eye movement patterns with standard clinical exams. The goal was to find a faster, easier way to track Pa…

This study tested whether using low-intensity focused ultrasound on a brain area called the zona incerta (ZI) can reduce tremors in people with Parkinson's disease. Twenty participants completed the study, which compared this new target to the standard target. The goal was to und…

This study looked at the gut bacteria of 15 people with inflammatory bowel disease (IBD) or Parkinson's disease and compared them to healthy individuals. Researchers collected stool and blood samples to see which bacteria were present and whether bacteria were leaking from the gu…

This study looked at how different types of exercise change brain activity in people with Parkinson's disease who have a deep brain stimulator. Fifteen participants cycled while their brain signals were recorded. The goal was to understand why exercise can improve movement, which…