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New brain stimulation pattern may help Parkinson's patients who 'Freeze' when walking

NCT ID NCT05415774

Symptom relief Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested a new way of using deep brain stimulation (DBS) to help Parkinson's disease patients who experience freezing of gait—a sudden inability to move their feet—even with standard DBS. Ten participants received stimulation at different frequencies in two brain areas (the subthalamic nucleus and substantia nigra pars reticulata) to see if it could reduce freezing episodes. The study measured changes using a questionnaire about freezing severity over one-month periods.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
deep brain stimulation device
What this could lead to
If it works, this could offer a new stimulation pattern to reduce freezing of gait episodes in Parkinson's patients who don't respond to standard deep brain stimulation.
What could go wrong
This is a very small pilot study with only 10 participants, so results may not apply to everyone. The approach is experimental and may not provide meaningful improvement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

10 people

The number who actually took part.

Started

Sep 2022

Finished

May 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Idiopathic PD defined as by the MDS Criteria ; 2. Patients submitted to STN-DBS, for at least 6 months; 3. Patients with STN-DBS at 130Hz; 4. Patients with a troublesome FoG according to the "NFOG-Q", Part II Item II ≥ 2 or Part III Item 7 ≥ 2; 5. Mini Mental State (MMS) ≥ 25 ; 6. Ventral contact of electrodes implanted in the SNr (according to analysis of activated tissue volume models (VTA)); 7. Patients with stable parkinsonian stimulation parameters and anti-parkinsonian treatments for one month before the inclusion visit; 8. Patients with H/Y stage ≤ 3 in the Med ON/Stim On condition (at 130Hz, S-stimulation); Exclusion Criteria: 1. Patient with atypical Parkinsonian syndrome; 2. Patient with severe FoG before DBS, i.e. MDS-UPDRS item 2.13 in Med ON ≥2 or MDS-UPDRS item 3.11 ≥2 in Med On; 3. Patient whose antiparkinsonian treatments were modified during the last month before inclusion; 4. Patient with H\&Y stage ≥4 in Med On/Stim On (at 130Hz, S-stimulation) ;

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson disease

Contacts and locations

Locations

  • Uh Toulouse

    Toulouse, 31000, France

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