Disease by etiologic mechanism

Researchers are comparing ceftobiprole, an intravenous antibiotic, with a standard combination of vancomycin plus aztreonam for treating acute bacterial skin and skin structure infections in hospitalized adults. The trial enrolls adults with serious skin infections such as cellul…

Researchers are testing a one-time gene therapy called exa-cel for people with severe sickle cell disease. The treatment uses CRISPR-Cas9 to edit a patient's own blood stem cells, which are then infused back after chemotherapy. The trial measures whether participants remain free …

This study tested whether offering hepatitis C (HCV) treatment right at methadone clinics helps more people get cured compared to sending them to outside specialists. Over 600 adults on opioid addiction therapy took part across 13 clinics in Ukraine. Some clinics provided simplif…

Researchers in India are studying whether a 4-month daily regimen that includes moxifloxacin can cure newly diagnosed, microbiologically confirmed pulmonary tuberculosis as effectively as the standard 6-month treatment. The study enrolls 550 adults aged 18 to 65 who have not yet …

Scabies is a skin condition caused by mites that burrow into the skin and cause intense itching. This trial compares two creams used to treat it: sulfur 7% and permethrin 5%. Ninety adults with scabies were assigned to one cream or the other. Sulfur was applied each evening for t…

Researchers are testing a vaccine called BNT113 in people whose cancers are driven by HPV16, a common virus linked to head and neck, cervical, and anogenital tumors. The trial enrolls two groups: one with head and neck cancer that has been treated and shows no signs of disease, a…

Researchers test a reduced-toxicity conditioning regimen before allogeneic stem cell transplant in children and young adults with blood cancers. The regimen combines fludarabine, full-dose busulfan, and anti-thymocyte globulin. The trial measures transplant-related mortality at o…

Researchers test a reduced-intensity conditioning regimen before allogeneic stem cell transplant in adults with high-risk AML, MDS, or ALL who cannot tolerate standard intensive treatment. The regimen combines clofarabine, busulfan, and thymoglobulin. The trial measures relapse r…

Researchers test a gentler conditioning regimen before allogeneic stem cell transplantation in adults with blood cancers. The goal is to see if this reduced-toxicity approach lowers the risk of death within the first year after transplant. Participants receive fludarabine, busulf…

Researchers are testing a treatment called TOOKAD Soluble vascular targeted photodynamic therapy in men with localized intermediate-risk prostate cancer. The approach uses a drug activated by light to destroy cancer tissue in the prostate. The trial follows 50 men for up to 60 mo…

Researchers are testing two experimental oral antimalarial drugs, cipargamin and INE963, given alone or in combination, against standard malaria treatment. The trial enrolls people aged 12 and older who have uncomplicated falciparum malaria and weigh between 35 and 90 kilograms. …

Researchers are running a first-in-human study of LXE408, an experimental oral tablet, to see how safe and well tolerated it is in healthy adults. About 88 healthy volunteers aged 18 to 65 will receive single or multiple ascending doses of LXE408 or a placebo. The study also meas…

This study tests a new vaccine (iNTS-GMMA) designed to prevent severe Salmonella infections caused by two common strains. Researchers are giving the vaccine to healthy adults, children, and infants in Ghana to check if it is safe and triggers a strong immune response. The ultimat…

Researchers are testing whether a 13-valent pneumococcal conjugate vaccine is safe and prompts a strong immune response in healthy infants in India. The trial enrolls 708 infants who receive the vaccine or an older seven-strain version alongside their routine childhood shots. The…

Researchers are testing six different formulations of a cell culture-derived H2N3 influenza vaccine in about 600 healthy adults aged 18 and older. Participants receive two injections three weeks apart and are followed for about a year. The study measures antibody levels and check…

This study tested two experimental nasal spray vaccines in 24 children aged 2 to 5 years. The vaccines target two viruses that can cause breathing problems: human metapneumovirus (HMPV) and parainfluenza virus type 3 (HPIV3). The main goal was to see if the vaccines are safe and …

This large Phase 3 trial tested an experimental mRNA-based flu vaccine (mRNA-1010) against standard flu shots in over 40,000 adults aged 50 and older. The goal was to see if the new vaccine is safer and better at preventing flu-like illness caused by influenza A or B. Researchers…

Researchers are testing an inactivated enterovirus 71 (EV71) vaccine in healthy infants and children aged 2 months to 6 years. The trial aims to see if two shots of the vaccine can prevent hand, foot and mouth disease caused by EV71 and reduce severe complications like neurologic…

This early-phase trial is testing a new way to deliver radiation therapy for people with advanced head and neck cancer. Using MRI guidance, doctors can adjust the radiation dose in real time—giving higher doses to remaining tumor while reducing doses to areas that have shrunk. Th…

This completed Phase 2 study tested an oral antiviral drug called S-892216 in 282 adults with mild-to-moderate COVID-19. Participants took either the drug or a placebo tablet for a short time. The main goal was to see if the drug could lower the amount of virus in the nose and th…

This study looks at whether adding a combination of two drugs (naltrexone and bupropion) or a behavioral weight-loss program can help people who didn't lose enough weight after bariatric surgery. About 84 participants will receive either the drugs, behavioral therapy, both, or a …

Researchers compare two surgical approaches for primary congenital glaucoma, a rare eye condition in children that raises pressure inside the eye. One group receives a combined operation: nasal goniotomy plus temporal trabeculotomy. The other group receives temporal trabeculotomy…

Researchers at Xiangya Hospital of Central South University are comparing different sedation regimens used for patients with severe pneumonia in the intensive care unit. The study looks at 260 patients and measures how long they need mechanical ventilation, how well sedation targ…

This early-stage trial is testing a drug called vixarelimab in 24 people with moderate to severe ulcerative colitis who have not improved with standard treatments. The study looks at how the drug affects the gut, how it moves through the body, and whether it is safe. It is too ea…

This early-stage study tests a new drug called LY3971297 in healthy volunteers, people with obesity and high blood pressure, and those with reduced kidney function. The main goal is to check for side effects and measure how the drug moves through the body. The study involves up t…

This study tested two new treatments for people with small cell lung cancer that came back after initial chemotherapy. The experimental drugs, lurbinectedin alone or with irinotecan, were compared to standard treatments (topotecan or irinotecan). The goal was to see if the new op…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This trial tests whether efgartigimod, an injected drug that blocks certain immune antibodies, can improve muscle strength and function in adults with active idiopathic inflammatory myopathy — a group of rare autoimmune diseases that cause muscle inflammation and weakness. About …

Researchers are testing whether delivering chemotherapy directly into the liver through a catheter in the hepatic artery can help people with biliary tract cancer or colorectal cancer that has spread to the liver and stopped responding to standard intravenous chemotherapy. The st…

This phase 2 study tested whether adding the targeted drug erlotinib to standard chemotherapy (docetaxel) works better than chemotherapy alone for people with advanced non-small cell lung cancer whose first treatment stopped working. 156 participants were randomly assigned to one…

This study tests whether dapagliflozin, a drug currently used for diabetes, can help control inflammation in people with mild-to-moderate ulcerative colitis. Researchers will give 50 adults either dapagliflozin plus standard mesalamine or mesalamine alone, and track changes in sy…

Researchers are testing whether switching from a standard three-drug HIV regimen to a two-drug regimen keeps the virus under control just as well. The trial enrolls 134 adults whose HIV is already suppressed on a three-drug regimen and randomly assigns them to continue that regim…

This early-phase trial tests whether adding an experimental drug called NKTR-255 to standard CAR-T cell therapy can improve outcomes for people with large B-cell lymphoma that has returned or not responded to treatment. The study involves 27 adults and focuses on safety and how w…

Researchers are testing whether a telehealth counseling program can reduce heavy drinking and improve HIV viral control in people with HIV. Participants receive either a single brief alcohol counseling session or that session plus a referral to a program with multiple video couns…

This phase 2 trial tests an experimental drug called XmAb20717 in 27 adults with advanced biliary tract cancers (bile duct or gallbladder cancer) that worsened after standard chemotherapy. The drug is a bispecific antibody designed to activate the immune system against cancer by …

This phase 2 trial tests a daily oral drug called sevasemten (EDG-5506) in 244 adults and adolescents with Becker muscular dystrophy, a condition that causes progressive muscle weakness. The study compares the drug to a placebo to see if it can reduce muscle damage, improve walki…

Langerhans cell histiocytosis is a rare disease in which immune cells called Langerhans cells build up in organs and cause damage. This phase 2 trial gives adults newly diagnosed with the disease a combination of two chemotherapy drugs, methotrexate and cytosine arabinoside (cyta…

Researchers are running a Phase I trial of HG146, an experimental oral drug, in adults with advanced solid tumors or lymphoma that have worsened despite standard treatments. The study first tests HG146 alone to find a safe dose, then tests it combined with a PD-(L)1 antibody, a t…

This early-stage study tests a new drug, BGB-11417, in 64 adults with B-cell blood cancers that have come back or not responded to prior treatments. The main goals are to find the safest dose and understand side effects. Researchers will also look for signs that the drug shrinks …

This study tests whether a two-step drug treatment can improve bone density in people with long-term spinal cord injury who have bone loss. Participants receive either romosozumab (a bone-building drug) or a placebo for 12 months, followed by denosumab (a bone-strengthening drug)…

This study tested a new weekly injection called UBT251 in 205 overweight or obese adults to see if it helps with weight loss. Participants received different doses of the drug or a placebo for 24 weeks. The main goal was to measure the percentage change in body weight, with addit…

This study tested a new inhaler that combines three medicines (CHF 5993) against a two-medicine inhaler (CHF 1535) in over 3,400 people with COPD. The goal was to see if the triple combination improves lung function and reduces serious breathing attacks over 52 weeks. Participant…

Researchers are testing a new oral drug called rintodestrant (G1T48) in women with advanced breast cancer that is estrogen receptor-positive and HER2-negative. The trial gives the drug alone or with palbociclib, a standard breast cancer medicine. The main goals are to find a safe…

Researchers are testing a drug called APR-246 combined with azacitidine in people with myeloid blood cancers that carry a TP53 mutation, including myelodysplastic syndrome, acute myeloid leukemia, myeloproliferative neoplasms, and chronic myelomonocytic leukemia. The trial aims t…

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

Researchers are testing whether GNR-068, a ustekinumab biosimilar, works as well as the reference drug Stelara in adults with moderate to severe plaque psoriasis. About 422 participants receive either GNR-068 or Stelara as injections over several months, and everyone eventually r…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to bone tumors before surgery is safe and can prevent the cancer from returning. About 39 adults with cancer that has spread to their bones and who need surgery to stabilize a fracture risk will recei…

This early-stage trial tests a drug called PH-762, injected directly into skin tumors, for people with squamous cell carcinoma, melanoma, or Merkel cell carcinoma. Participants receive four weekly injections into one tumor, then have it surgically removed about two weeks later. T…

Researchers are comparing two first-line treatment strategies for women with advanced HER2-positive breast cancer: pertuzumab plus trastuzumab and docetaxel, versus trastuzumab and docetaxel alone. The study uses real-world electronic health records from about 2,250 patients trea…

Researchers in China are testing three exercise programs for children and teens with obesity or metabolic syndrome. Participants are randomly assigned to low, moderate, or intermittent high intensity training using broadcast gymnastics and sports dance. The study measures changes…

This study tests a vaccine designed to help the immune system fight HPV-positive throat cancer. It is for patients who have completed surgery or chemoradiation and show no signs of cancer remaining. The trial will enroll 24 adults to find the safest and most effective dose by mea…

This study adapts a wellness program called Chetana to help men who have sex with men (MSM) and transgender women (TGW) in India who are living with HIV stay engaged in care. The program includes yoga, nutrition, legal advice, mental health support, and peer navigators who provid…

This study tests a drug called leniolisib in 20 people with common variable immunodeficiency (CVID), a condition that weakens the immune system. All participants will receive the drug for 6 months, starting at a low dose and increasing. The main goal is to check safety and tolera…

This study tests whether a steroid injection given during retinal detachment surgery can replace the usual course of antibiotic and steroid eye drops afterward. About 168 adults with a first-time retinal detachment will receive either the injection or standard drops. The goal is …

Researchers are testing an experimental antibody drug called verekitug in adults with chronic rhinosinusitis with nasal polyps, a condition where inflamed tissue grows inside the nasal passages and causes congestion. Participants receive either verekitug or a placebo injection wh…

This study tests a nasal spray called OPN-375 in about 72 teenagers (ages 12-17) who have nasal polyps—growths inside the nose that cause stuffiness and breathing trouble. The spray is given twice a day for 16 weeks, and some participants receive a placebo (inactive spray) for co…

Researchers are testing whether adding the immunotherapy drug tislelizumab to standard TAC chemotherapy helps shrink triple-negative breast cancer before surgery. The trial enrolls 36 women with newly diagnosed triple-negative breast cancer. Participants receive six cycles of tis…

Researchers are testing an experimental oral drug called MDR-001 in healthy adults and in people who are overweight or obese. The trial gives single and increasing repeated doses to see how the body processes the drug and whether it causes side effects. They also measure changes …

This phase III trial tests whether adding low-dose methotrexate to standard corticosteroid treatment works better than steroids alone for adults who develop acute graft-versus-host disease after a stem cell transplant. Participants receive either methotrexate or a placebo alongsi…

This completed Phase 4 trial tested two different doses of chemotherapy (standard and low-dose) combined with the immunotherapy drug Sintilimab in 20 people with advanced squamous non-small cell lung cancer. The goal was to see if the lower-dose combination could shrink tumors an…

This Phase 3 study tests whether adding tiragolumab (an experimental immunotherapy) to the standard combination of atezolizumab plus chemotherapy can help people with untreated, widespread small cell lung cancer live longer without their disease worsening. About 123 participants …

This study tests a new drug combination for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The two drugs, LY3295668 and osimertinib, work by blocking enzymes that help cancer cells grow. The goal is to find the safest dose and see if…

This Phase 3 study tests whether a gel containing patidegib can lower the number of new basal cell carcinomas (a type of skin cancer) on the face of adults with Gorlin syndrome. Participants apply the gel or a placebo to their face twice daily for a year. The study will compare h…

Ulcerative colitis causes ongoing inflammation in the colon and rectum, and current treatments do not work for everyone. Researchers are testing whether adding pentoxifylline, a drug with anti-inflammatory and antioxidant effects, to standard care can reduce disease activity. The…

Researchers compare two weight-loss strategies in 66 obese women: a 16:8 time-restricted eating plan (fasting 16 hours, eating within 8 hours) plus home exercise, versus a standard calorie-restricted diet plus home exercise. Over 12 weeks, they measure changes in body composition…

Researchers are testing whether a 24-month weight-loss program delivered by trained health coaches through an electronic medical record patient portal can help Black adults with obesity and type 2 diabetes or prediabetes. The study enrolls 352 people aged 40 to 70 in Louisiana pr…

This study tested whether monthly injections of two HIV drugs (cabotegravir and rilpivirine) work better than daily oral pills for people with HIV who have a history of missing doses. Over 450 participants were enrolled. The goal was to see if the long-acting shots reduce the cha…

This study is testing whether adding an experimental anti-inflammatory drug called NT-0796 to the weight-loss medication semaglutide can help people with obesity lose more weight and reduce inflammation. About 82 adults with a BMI of 30 to 45 will take either the combination or a…

Researchers are testing a combination of rituximab, acalabrutinib, and durvalumab in adults with primary central nervous system lymphoma, a rare cancer that starts in the brain or spinal cord. The trial enrolls people whose disease has returned or worsened after earlier treatment…

This study tested whether taking the drug abiraterone on an on-and-off schedule could help it work longer for men with advanced prostate cancer that no longer responds to hormone therapy. Nineteen men whose cancer had already responded to standard daily abiraterone were enrolled.…

Researchers are testing whether lucitanib, an oral drug, can slow the growth of advanced thymic carcinoma that has worsened after at least one round of chemotherapy. The trial enrolls adults with recurrent or metastatic thymic carcinoma. In one part, participants receive lucitani…

Researchers are testing whether adding fruquintinib to standard chemotherapy (mFOLFOX6 or FOLFIRI) helps people with metastatic colorectal cancer who have not yet received treatment for advanced disease. The trial enrolls adults up to age 75 with confirmed metastatic colorectal c…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

Researchers compare two versions of corneal crosslinking to treat progressive keratoconus or corneal ectasia, conditions where the cornea thins and bulges. Both use riboflavin eye drops and ultraviolet light, but one delivers the light faster and more intensely. The trial measure…

This study tests whether survodutide, a weekly injection for weight loss, is safe for the heart in people who are overweight or obese and have heart or kidney disease. About 5,500 adults will receive either survodutide or a placebo for up to 2 years, along with diet and exercise …

Researchers are testing sorafenib, a drug that blocks enzymes tumors need to grow and cuts off their blood supply, in people with angiosarcoma that is locally advanced, has spread, or cannot be removed by surgery. The trial enrolls about 88 participants and measures how many rema…

This phase 3 trial is testing the safety and tolerability of fenfluramine (Fintepla) in 25 infants aged 1 to 2 years with Dravet syndrome, a severe form of epilepsy. The drug is given as an oral solution twice daily alongside other seizure medications. Researchers will monitor he…

This study tests whether special breathing techniques called neurophysiological facilitation of respiration can improve oxygen levels and shorten hospital stays in children aged 6 months to 2 years with pneumonia. The techniques involve gentle stretches and co-contraction of the …

This study tested two treatments for people with advanced cancer who cannot have standard therapy. One group took a low-dose chemotherapy pill (cyclophosphamide) daily, and the other took a hormone pill (megestrol). The goal was to see which treatment could slow cancer growth for…

This phase 2 study tested the drug erdafitinib in 316 adults and children with advanced solid tumors that have specific FGFR gene mutations or fusions. The main goal was to see if the drug could shrink tumors. Participants took erdafitinib tablets daily. The study is now complete…

Researchers are testing two ways to give the HIV drug dolutegravir to people who also have tuberculosis and are taking rifampin-based TB therapy. Rifampin can lower dolutegravir levels in the body, so the trial compares taking 50 mg once daily with food against taking 50 mg twice…

Researchers are testing whether combining cetuximab, a drug that blocks tumor growth, with stereotactic body radiation therapy can help patients whose head and neck cancer has returned after earlier radiation and cannot be removed by surgery. The trial enrolls about 45 people wit…

Researchers are studying aflibercept (Eylea), an anti-VEGF drug given as an injection into the eye, in adults aged 50 and older with wet age-related macular degeneration. Everyone in the trial receives three monthly loading doses over 12 weeks. The team uses detailed retinal scan…

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This study looks at the long-term safety of filgotinib, a drug for ulcerative colitis, in over 1,100 adults who already took part in a filgotinib trial. The main goal is to track side effects and lab test changes over time. Participants must have completed a prior filgotinib stud…

This early-phase trial tested two cancer drugs—imatinib mesylate and cyclophosphamide—given daily by mouth to 26 people with rare, advanced tumors that had no standard treatment. The main goal was to find the safest dose of imatinib when combined with a fixed dose of cyclophospha…

This study tests a combination of laser heat therapy (LITT) and the immunotherapy drug pembrolizumab in 32 adults with recurrent glioblastoma, an aggressive brain cancer. The laser heats and destroys hard-to-reach tumors, while pembrolizumab helps the immune system fight cancer c…

Researchers are testing whether adding vitamin B12 to standard chemotherapy helps people with pleural mesothelioma that cannot be removed by surgery. The trial gives participants pemetrexed and cisplatin, two chemotherapy drugs that block tumor cell growth in different ways, alon…

Researchers are testing a radiation technique called PULSAR in people with metastatic cervical cancer. PULSAR delivers radiation in short bursts to pelvic tumors, guided by imaging, alongside standard systemic therapy. The trial aims to see whether this approach improves overall …

This study tested whether adding the drug nintedanib to standard chemotherapy (docetaxel) helps people with advanced HER2-negative breast cancer live longer without their disease getting worse. Fifty-one adults who had already received some treatment took part. The goal was to se…

Researchers are testing an experimental immunotherapy called GNR-051 in adults with advanced lung cancer, kidney cancer, or melanoma that has returned or not responded to other treatments. The Phase 1 trial aims to find the highest dose people can tolerate and to track side effec…

This study tested a drug called saroglitazar magnesium in 196 adults with primary biliary cholangitis (PBC), a chronic liver disease. Participants either took the drug or a placebo to see if it improved liver function markers. The goal was to lower certain liver enzymes and bilir…

This early-phase trial tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to turn back on genes that may slow tumor growth. The main goal was to find a safe dose and check for side effect…

This study tested an artificial version of the LCAT enzyme (ACP-501) in one person with familial LCAT deficiency, a rare genetic condition that leads to low 'good' cholesterol and kidney failure. The participant received several infusions of the drug over weeks, with regular bloo…

This study tests two experimental drugs, ERAS-007 and ERAS-601, in people with advanced solid tumors that have not responded to standard treatments. The drugs are taken orally and aim to block signals that help cancer grow. The trial will first find safe doses and then check if t…

This completed Phase 2 trial tested fecal microbiota transfer (FMT) – a freeze-dried product made from healthy donor stool – in 40 women with recurrent urinary tract infections (UTIs). The goal was to see if FMT could prevent future UTIs by restoring healthy gut bacteria. Researc…

This early-phase trial tested whether adding nilotinib (a pill) to paclitaxel (a chemotherapy) is safe and tolerable for people with advanced solid tumors that no longer respond to standard treatments. The study included 47 adults and children aged 12 and older. Researchers aimed…

Researchers at the University of Miami are testing two ways to help men who have sex with men take their HIV prevention medication, known as PrEP, more consistently. One group receives four weekly counseling sessions with a nurse, using techniques from cognitive behavioral therap…

This study tests whether a cookie made from Golden Rice and red betel leaf can improve cholesterol and triglyceride levels in adults with type 2 diabetes. Over 28 days, 102 participants will eat the cookies daily, and their blood fat levels will be measured before and after. The …

This study tests an experimental drug called AVD-104, given as an eye injection, for people with geographic atrophy, a late stage of dry age-related macular degeneration that causes blind spots. The trial involves 300 participants and aims to see if the drug is safe and can slow …

This early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take pa…

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

Researchers are studying whether trained community workers can safely deliver HIV treatment outside clinics in Cambodia. The trial enrolls about 4,000 people living with HIV who have stable treatment and no complications. Community action workers receive training to dispense drug…

This early-phase study tested a new approach for people whose B-cell cancers (like lymphoma or leukemia) came back after a donor stem cell transplant. Researchers took white blood cells from the original donor, genetically modified them to recognize and attack cancer cells, and g…

This study tests a mix of antibodies that help the immune system fight cancer, block tumor growth signals, and cut off the tumor's blood supply. It is for adults with head and neck cancer that did not respond to prior treatment or has no standard options. Participants receive inf…

This study tests whether adding the immunotherapy drug nivolumab (Opdivo) to standard radiation and hormone therapy is safe and effective for men with a very aggressive form of prostate cancer (Gleason grade group 5). About 44 men will receive the drug combination. The goal is to…

This phase 3 trial tests whether VCT220, a daily pill that targets GLP-1 receptors, can help overweight or obese adults lose weight. About 840 participants will take either a high dose, low dose, or placebo for 12 months. The main goals are to see how much weight they lose and ho…

Researchers are testing whether adding simvastatin, a widely used cholesterol-lowering drug, to zoledronic acid helps women with breast cancer that has spread to bone. Thirty-five women who have already received chemotherapy receive either simvastatin or a placebo alongside zoled…

Researchers are testing a combination of L-DEP chemotherapy (aspargase, liposomal doxorubicin, etoposide, and methylprednisolone) and a PD-1 antibody as initial treatment for people with Epstein-Barr virus-positive lymphoma-associated hemophagocytic lymphohistiocytosis, a rare an…

This early-phase study tested the safety of rituximab, a drug that targets faulty white blood cells, in 7 adults with rare immune diseases like pulmonary alveolar proteinosis and severe candidiasis. Participants received several doses over 6 months and were monitored for 18 month…

Researchers at UT Health San Antonio are testing a mobile app called PL4Y to see if it helps young people recently diagnosed with HIV stay connected to medical care. The pilot study enrolls 29 participants who either have a recent diagnosis, a high viral load, or have missed HIV …

Researchers are testing whether a ketone supplement drink can reduce protein in the urine and improve kidney function in people with chronic kidney disease or polycystic kidney disease. The study includes 45 participants who receive either the ketone drink or a placebo for four w…

Researchers compare three weekly GLP-1 receptor agonists, dulaglutide, semaglutide, and tirzepatide, in 159 obese adults, 84 with diabetes and 75 without. Participants receive one of the drugs for 24 weeks. The trial measures changes in body weight, BMI, blood sugar, cholesterol,…

Researchers are testing an experimental drug called TAK-935 in children aged 2 to 17 with Dravet syndrome or Lennox-Gastaut syndrome, two severe forms of epilepsy that often resist treatment. The trial compares TAK-935 added to standard anti-seizure medications against a placebo …

Progressive supranuclear palsy (PSP) is a rare brain disease that steadily damages movement, balance, and thinking. Researchers are testing valproic acid, a drug already used for epilepsy and mood disorders, to see if it can protect brain cells by blocking an enzyme involved in t…

Researchers compare two three-drug combinations, VTD and VCD, as initial treatment for people newly diagnosed with multiple myeloma who are eligible for a stem cell transplant. Participants receive four cycles of either combination. The trial measures how well each combination re…

Researchers are testing whether adding tocilizumab, a drug that blocks an inflammation signal called IL-6, to standard chemotherapy helps adults with high-risk acute myeloid leukemia. Participants receive idarubicin and cytarabine, the usual induction chemotherapy, plus a single …

Atypical hemolytic uremic syndrome (aHUS) is a rare disease that damages the kidneys by causing blood clots in small vessels. The drug eculizumab blocks the complement system and has greatly reduced kidney failure, but doctors do not know how long patients should stay on it. This…

Researchers are testing whether adding the experimental drug MLN9708 to lenalidomide and dexamethasone can help adults under 66 with newly diagnosed multiple myeloma. Participants receive three cycles of the triplet, then a stem cell transplant, followed by more triplet and maint…

Researchers are studying whether an enhanced package of care helps people with advanced HIV in Malawi stay in treatment and keep the virus suppressed. The package adds CD4 and TB-LAM tests and starts patients on TB preventive therapy, delivered through a hub-and-spoke system of c…

Researchers are testing whether a liposomal chemotherapy drug called CPX-351 works better than standard chemotherapy before an allogeneic stem cell transplant in adults with higher-risk myelodysplastic syndromes (MDS) or oligoblastic acute myeloid leukemia (AML). The trial enroll…

Polycystic ovary syndrome (PCOS) often comes with insulin resistance, cholesterol problems, and other metabolic issues. Researchers are testing whether metformin, a common diabetes drug, changes metabolic, vitamin B12, iron, and blood measures in women with PCOS, and whether addi…

Researchers are studying a spinal implant called the EVOS Lumbar Interbody System, which uses PEEK-OPTIMA HA enhanced cages, in adults with degenerative disc disease or grade 1 spondylolisthesis in the lower back. The study follows participants who receive the device during spina…

In sub-Saharan Africa, tuberculosis often causes sepsis in people living with HIV, and many die within days. This phase 3 trial tests two changes to standard care: starting anti-TB therapy right away instead of waiting for test results, and using a higher, sepsis-specific dose in…

Researchers are testing whether combining bevacizumab, a drug that blocks new blood vessel growth, with Optune, a device that delivers electric fields to the brain, can help people with recurrent high-grade meningioma. Participants wear the Optune device for at least 18 hours a d…

Researchers are testing a daily application of roflumilast cream 0.3% in people with chronic plaque psoriasis to see if it is safe and effective over 24 weeks. The study includes adults and children aged 2 and older, some who have used the cream before and some who have not. Part…

Hospitals use different definitions to diagnose undernutrition, and those definitions may label different numbers of patients as undernourished. This study compares the French HAS definition with the international GLIM definition in 260 adults hospitalized in diabetes-obesity, lu…

Women with pathological nipple discharge often need surgery to find the cause, but standard mammograms and ultrasounds can miss cancer. Researchers are testing a non-invasive breast scan called high-resolution magnetic resonance ductography (HR-MRD) that uses a powerful magnet an…

Researchers test whether checking infants with Down syndrome for obstructive sleep apnea every six months, starting at six months old, helps their brain development by age three. The trial compares a group that gets regular sleep studies to a group that receives standard care. Ab…

Researchers want to know whether a bedside device that measures how blood clots can predict which patients with an infection will develop sepsis. The study enrolls 147 adults arriving at an emergency department with a suspected infection. Everyone gives blood for the clotting mon…

Researchers are studying whether features from pretreatment 18F-FDG PET/CT scans can predict how well people with metastatic kidney cancer respond to first-line targeted therapy plus immunotherapy. The study reviews medical records and imaging data from 228 patients treated at a …

Researchers compare two devices, Amy Check and Osstell, for measuring the stability of dental implants placed during a graftless closed sinus lift. The trial enrolls 30 adults who need tooth replacement in the upper back jaw and have limited bone height. Each participant receives…

This study is testing a portable ultrasound device called POROUS R4C that measures bone in the lower leg without radiation. Researchers want to see if it can estimate bone mineral density as accurately as the standard X-ray method (DXA). The study will include 350 healthy men and…

Researchers are testing whether a combination of PET scans with a radioactive tracer called [18F]PSMA-1007, sodium MRI, and multiparametric MRI can accurately predict where prostate cancer is and how aggressive it is. The study enrolls men who are scheduled to have their prostate…

Researchers are studying whether small intestinal bacterial overgrowth (SIBO) is common in people with abdominal bloating or distension. Adults aged 18 to 70 with these symptoms take a breath test that measures hydrogen and methane in their exhaled air. The study aims to see how …

Malaria in pregnancy often causes no symptoms, yet it can lead to anaemia, premature birth, and low birth weight. Standard rapid tests miss many of these quiet infections. Researchers are comparing a new high-sensitivity rapid diagnostic test with conventional tests in 930 pregna…

People with cystic fibrosis often develop prediabetes and then diabetes, but doctors lack a good way to predict who will progress. This pilot study at Indiana University tests whether a continuous glucose monitor worn for up to 10 days, combined with a mathematical model called t…

Researchers are studying whether PET scans help doctors plan radiation more precisely for people with locally advanced head and neck cancer. Participants receive 3-dimensional conformal radiation therapy and intensity-modulated radiation therapy, which shape beams to the tumor. T…

This Phase 3 trial tests a radioactive imaging agent called 18F-mFBG to see if it can accurately detect neuroblastoma, a type of childhood cancer. The study involves 43 participants who either have or are suspected of having neuroblastoma. Researchers will compare the new PET sca…

Researchers are studying whether a point-of-care nucleic acid test can diagnose HIV faster than standard lab testing and help people get into care or prevention services sooner. The trial enrolls adults at a Seattle HIV clinic, including people living with HIV and those seeking t…

Malaria in pregnancy can hide in the placenta and harm both mother and baby, yet it often goes undetected. This study enrolls about 1,200 pregnant women in Africa to see whether malaria rapid diagnostic tests, blood smears, and PCR on maternal blood can accurately detect or predi…

Visceral leishmaniasis is a fatal parasitic disease if left untreated, and current methods to check whether treatment worked require invasive sampling of the spleen or bone marrow. Researchers at Gondar University Hospital in Ethiopia are evaluating blood-based immune and molecul…

Researchers in Senegal are testing a new way to care for children under 15 who come to primary health clinics with fever or diarrhea. The strategy combines rapid tests for malaria, dengue, and strep A with a digital tool that suggests treatment based on symptoms and test results.…

This study is testing whether a radiation-free ultrasound system called Scolioscan can accurately screen for scoliosis in school children. Researchers will compare ultrasound results with standard X-rays in 160 children referred for screening. If the ultrasound proves reliable, i…

Dengue fever is common in Burkina Faso, but primary health clinics often rely only on malaria rapid tests when a child arrives with fever. Researchers are testing a digital module that walks health workers through the country's dengue management guideline and pairs it with dengue…

This study tests whether a simple salt-water mouth rinse can detect pneumocystis, a lung infection that can be life-threatening in people with weak immune systems. Current diagnosis requires coughing up sputum or a tube inserted into the lungs, which can be uncomfortable. Researc…

Researchers in Georgia are testing whether mailing hepatitis C self-tests to people who inject drugs and men who have sex with men increases how many get tested. The trial enrolls 1,250 adults in Tbilisi and Batumi who do not know their hepatitis C status. Half receive a self-tes…

Researchers in Karachi, Pakistan, are studying whether delivering hepatitis C self-tests to people's homes increases how many get tested. The trial enrolls about 2,000 adults who live in two areas of the Malir district and have not recently been tested. Half receive a self-test k…

Researchers are testing whether giving people in Malaysia a rapid hepatitis C self-test kit to use at home increases how many get tested, compared with standard clinic-based testing. The trial enrolls 750 adults who are not known to have hepatitis C and have not been tested in th…

Researchers at Hanoi Medical University are studying whether two blood markers, AFP-L3 and PIVKA-II, can accurately detect hepatocellular carcinoma, the most common form of liver cancer. The trial enrolls 200 adults, including people with liver cancer and people with benign liver…

Researchers at ETH Zurich are testing whether analyzing exhaled breath can diagnose lactose intolerance. The study includes 112 adults aged 18 to 65 in the Zurich area who consume a lactose or glucose solution. By measuring specific gases in the breath and comparing them to urine…

Researchers are testing the Liver Incyte system, an ultrasound device that measures how stiff the liver is, to see if it can tell healthy people apart from those with liver fibrosis or steatosis. The trial includes 140 adults, some healthy and some with a history of hepatitis C o…

Researchers are studying whether lung ultrasound can reliably show the patterns of COVID-19 pneumonia in hospitalized patients. The trial enrolls adults admitted with confirmed COVID-19 and respiratory symptoms who need a chest CT scan. By comparing ultrasound images with CT scan…

Researchers are testing a device called Glyconics-DS that shines near-infrared light on a fingernail to measure glycated keratin, a marker linked to blood sugar. The trial enrolls about 486 adults who do not know their diabetes status and compares the scan result with a standard …

Researchers are testing whether tissue samples taken during a routine colon exam can help tell apart Parkinson's disease from two similar conditions: multiple system atrophy and progressive supranuclear palsy. The study includes 34 people aged 50 to 80, some with these conditions…

Researchers are studying whether a specialized lung MRI scan can detect changes in lung blood flow in children with cystic fibrosis before and after they start Trikafta, an FDA-approved treatment. The study enrolls 48 children aged 6 to 11 who have cystic fibrosis and at least on…

Children with sickle cell disease who are hospitalized for painful vaso-occlusive crises can develop acute chest syndrome, a serious lung complication. Doctors usually diagnose it with a chest X-ray, but researchers want to know whether lung ultrasound works as well or better. In…

Researchers compare PET scans and MRI to see which imaging method detects more myeloma lesions in adults under 65 with newly diagnosed multiple myeloma. Participants receive both scans at diagnosis, after three cycles of chemotherapy, and at the end of treatment. The study also t…

Researchers are testing whether a very-low-carbohydrate diet can help adults with prediabetes and obesity lose weight, reduce body fat, and improve insulin sensitivity. The trial enrolls adults aged 30 to 65 with obesity and newly diagnosed prediabetes. Participants are randomly …

This study tests whether a pill called mitoquinone can prevent COVID-19 in healthy adults who have had close contact with someone who has COVID-19. About 112 participants will receive either the pill or a placebo. The goal is to see if it stops infection and reduces symptoms.

Researchers are testing whether a six-month supervised exercise program can improve forearm muscle strength and support radial bone health in older adults living in nursing homes. Thirty-four participants are assigned to either an exercise group or a control group. The exercise g…

Researchers are testing whether a high-protein diet before and after abdominal surgery helps older veterans recover better. Participants receive either 30 grams of protein three times a day for two weeks before and four weeks after surgery, or standard nutrition education with on…

Researchers are testing whether adding an in-service professional development component to the WayToServe online responsible beverage service training helps alcohol servers refuse service to intoxicated patrons more often. The trial enrolls licensed premises owners, managers, and…

This study tested whether treating private well water with ultraviolet (UV) light can prevent stomach and respiratory infections in children under 5. Researchers gave 28 Pennsylvania households either a real UV device or a fake one and tracked illness symptoms via weekly texts. T…

This study tests whether a dental assistant can help patients with head and neck cancer keep their mouths clean during and after radiotherapy. Patients receive oral hygiene education and a written guide before treatment starts. Researchers measure plaque levels at the beginning a…

Researchers are testing whether pirfenidone, a drug that reduces inflammation and scarring, can prevent radiation pneumonitis in people with advanced lung cancer. Participants have already received immune checkpoint inhibitors and need chest radiation. The trial gives pirfenidone…

Women with class III obesity who gain too much weight during pregnancy face higher risks of diabetes, high blood pressure, cesarean delivery, and larger babies. Standard prenatal care often does not include nutrition counseling based on weight. This trial tests whether adding gro…

This study tests several new mRNA-based flu vaccines in about 971 healthy adults aged 18 and older. The goal is to see how well they trigger an immune response and how safe they are compared to standard flu shots. Participants receive one dose of an experimental vaccine or a comp…

Researchers test whether short messages sent through a mobile wellness app can increase flu vaccination rates among insured adults. The messages, delivered as push notifications and in-app posts, either highlight incentives or use generic wording. The study compares vaccination r…

Researchers compare one French middle school that used the e-Bug educational programme with other schools in the region to see whether classroom lessons about vaccination relate to higher HPV and meningococcal ACWY vaccine coverage. The study uses only aggregated, anonymised vacc…

Researchers in Shangrao, China, are testing whether short exercise videos played during school breaks can increase physical activity and improve attitudes toward exercise in overweight and obese children aged 9 to 15. About 100 participants are randomly assigned to either follow …

This study tests whether a mobile app called Safety in Seconds can effectively teach parents of infants about safe sleep practices to reduce the risk of Sudden Unexpected Infant Death (SUID). The app delivers educational modules on safe sleep, such as placing babies on their back…

Researchers are testing a field-based sexual health program for people recently exposed to HIV who were notified by New York City's partner services program. The program adds four services to standard contact tracing: HIV and STI testing in the field, same-day start of HIV preven…

Hospital-acquired infections are a major problem in low- and middle-income countries. Researchers are developing and piloting an infection prevention and control program for healthcare workers in Cambodia and Laos. The program aims to improve hand hygiene and equipment disinfecti…

Critically ill children with central venous catheters face a risk of bloodstream infections that can lead to longer hospital stays and serious complications. Researchers are testing whether bathing these children daily with a 2% chlorhexidine gluconate solution prevents central l…

Researchers are testing whether an antiviral tablet called S-217622 can prevent symptomatic COVID-19 in people who live with someone who has symptoms. The trial enrolls household contacts of a person with symptomatic COVID-19 and gives them either the antiviral or a placebo for a…

Researchers at Stanford University are testing whether the Diabetes Body Project, a six-session group program, can reduce eating disorder symptoms and improve blood sugar control in young women with type 1 diabetes. The study enrolls 55 female-identifying participants aged 15 to …

Very premature infants born before 28 weeks often have a blood vessel near the heart, called the patent ductus arteriosus, that stays open when it should close. A large opening can strain the heart and may affect brain development. In this trial, researchers use an early echocard…

Researchers are testing a school-based program that screens adolescents for anxiety, depression, and other mental health concerns, then offers stepped support. Students at eight schools in Spain complete regular mental health questionnaires. Based on their results, they receive d…

Researchers are testing whether low-dose tamoxifen or a 5:2 intermittent fasting diet can raise levels of a protein called sex hormone binding globulin (SHBG) in women at high risk of breast cancer. Higher SHBG levels have been linked to lower breast cancer risk. The trial enroll…

Researchers are testing an antiviral drug called tecovirimat to see if it is safe and well tolerated when taken by mouth for 14 days. The trial enrolls healthy adults aged 18 to 80 and compares tecovirimat with a placebo. The goal is to gather safety information that could suppor…

Researchers are studying whether an antiviral drug called tecovirimat (TPOXX) is safe and well tolerated when taken by mouth twice daily for 28 days. The trial enrolls healthy adults aged 18 to 80 and compares TPOXX with a placebo. The main goal is to measure drug levels in the b…

Researchers at Akdeniz University are testing Care-Up, a mobile-friendly web tool that gives family caregivers structured guidance on skin care, pressure-injury prevention, urinary-risk signs, nutrition, hydration, and when to call a professional. The trial enrolls 66 patient-car…

Researchers at George Washington University are testing a program called Juntas Adelante to see if it helps Latina transgender women in the Washington DC area learn about and use HIV prevention medicines. The program includes five short online videos and up to two virtual coachin…

Researchers at the University of Washington are adapting a brief narrative therapy session for use in a low-barrier primary care clinic that serves people experiencing homelessness in North Seattle. The study enrolls 64 adults who have had at least one therapy appointment at the …

This study tested whether ketoconazole, an antifungal drug, can reduce the skin rash caused by EGFR inhibitor cancer therapy. 58 participants with ongoing rash were given either ketoconazole or a placebo. The main goal was to see if the drug improved rash symptoms and quality of …

This study tests whether using a special monitor (ANI) during ovarian cancer surgery to guide pain medicine can lower the chance of chronic pain three months after the operation. About 126 women having open surgery for ovarian cancer will be randomly assigned to standard care or …

This study tested a device called Cereset Research that plays tones in response to a person's brainwaves, aiming to reduce stress and improve sleep. 94 stressed healthcare workers used the device for several sessions and were followed for a year. The goal was to see if the device…

Hailey-Hailey and Darier disease are rare inherited skin conditions that cause painful, itchy lesions in skin folds. Sweating makes them worse, and standard treatments often do not work well. Researchers are testing whether botulinum toxin injections into large skin folds can red…

This study tested whether rivastigmine can safely reverse delirium caused by poisoning from certain drugs like clozapine or tricyclic antidepressants. 100 patients at a poison center received rivastigmine, and doctors measured their consciousness and agitation levels. The goal wa…

Researchers are testing whether injections of botulinum toxin into the soles of the feet can reduce blistering in people with localized epidermolysis bullosa simplex, a rare skin condition that causes painful foot blisters. The trial enrolls 18 people with similar blisters on bot…

Researchers are testing whether mazdutide, a weekly injection, can lower androgen levels in obese women with polycystic ovary syndrome (PCOS). The trial enrolls 43 women who receive increasing doses of mazdutide for 24 weeks. The main goal is to see if the drug reduces the free a…

This study tests whether a special infrared light can help nurses see veins better when placing IVs in lung cancer patients receiving chemotherapy. The goal is to reduce pain, improve comfort, and strengthen trust between patients and nurses. About 160 patients will take part, wi…

Researchers are testing whether an inhaled dual bronchodilator (umeclidinium/vilanterol) can improve heart function during exercise in people who have COPD, lung hyperinflation, and mild heart failure. About 60 adults aged 40 to 85 with these conditions will take either the drug …

Researchers are testing whether a structured program of interactions with horses improves quality of life for young people and women who have finished chemotherapy or radiotherapy for cancer or blood disorders. Participants are randomly assigned to receive standard follow-up care…

Researchers are testing whether inhaling a low dose of xenon gas can ease anxiety before laser vision correction. The trial enrolls 140 people who score high on stress and anxiety tests and are scheduled for ReLEx SMILE eye surgery. Participants receive either xenon or a standard…

Researchers are testing a cognitive behavioral therapy program designed for autistic teens who have anxiety, depression, or both. The therapy focuses on exposure and behavioral activation, with adjustments for autism. Teens and their caregivers take part together. The trial compa…

This study tests whether a daily supplement called APPORTAL® can reduce fatigue in breast cancer patients undergoing chemotherapy. The supplement contains a mix of vitamins, minerals, and other nutrients. 92 women will take either the supplement or a placebo for 8 weeks, alongsid…

This study tested whether taking a cistanche supplement for 8 weeks, along with a supervised training program, improves anaerobic exercise performance and recovery in young men. 56 men aged 18-25, either elite or amateur athletes, were randomly assigned to receive cistanche extra…

This study tests if shining a special near-infrared light on the head and through the nose can improve memory and brain function in older adults at risk for Alzheimer's disease. The treatment, called photobiomodulation, is low-risk and aims to boost brain cell energy. 168 partici…

This study tested a group teletherapy platform called TheraGroup for Black college students dealing with anxiety and depression. Forty students took part in 12 weeks of cognitive behavioral therapy (CBT) coping skills training delivered online in a group setting. The goal was to …

Researchers compare two chest drain sizes, 20-Fr and 24-Fr, in people having part of a lung removed for early-stage lung cancer. After surgery, each participant receives one of the two drains to clear fluid and air from the chest. The trial tracks complications such as collapsed …

Researchers at Hanoi Medical University are testing whether personalized meals and diet coaching help stomach and colon cancer patients who are starting chemotherapy. About 120 adults receive tailored menus in the hospital, then learn to prepare high-energy, high-protein diets at…

This study tests whether remimazolam, a newer anesthetic, can reduce the risk of postoperative delirium (sudden confusion) in elderly patients undergoing laparoscopic stomach cancer surgery. Researchers will compare remimazolam to standard anesthesia in 170 patients aged 65 and o…

This trial tests whether drinking lavender herbal tea twice daily for nine days around each menstrual cycle can reduce the emotional and physical symptoms of premenstrual syndrome (PMS), such as anxiety, depression, stress, and pain. Sixty women with PMS will be randomly assigned…

Researchers are testing whether the 4-7-8 breathing technique can reduce anxiety, ease symptom burden, and improve sleep quality in people receiving chemotherapy. The trial enrolls 64 adults undergoing their third treatment cycle, splitting them into a group that practices the br…

Researchers are testing an 8-session mindfulness-based self-compassion program for women diagnosed with breast cancer. The program combines meditation, yoga, and homework to help participants focus on the present moment. The trial measures changes in self-esteem and spiritual wel…

This trial tests whether immersive virtual reality or relaxing nature videos can reduce symptom severity, distress, and improve quality of life in people with lung cancer who are starting chemotherapy. Participants will be randomly assigned to one of three groups: virtual reality…

Researchers at Sohag University are studying a minimally invasive spine surgery called MI-TLIF for people with degenerative lumbar and lumbosacral spine diseases. The trial enrolls about 30 adults with conditions such as degenerative spondylolisthesis, disc herniation, or recurre…

This study tests whether ketamine can reduce fatigue and improve thinking in people with Long COVID. Twenty adults aged 18–65 with ongoing tiredness or brain fog will receive four ketamine injections over two weeks. Researchers will track changes in symptoms, brain scans, and inf…

Researchers compare kalifilcon A daily disposable toric contact lenses with Ultra for Astigmatism lenses in adults who already wear soft contacts and need astigmatism correction. Each participant wears both lens types for about one week each, in random order. The study measures h…

Researchers test a 10-week lifestyle program for people who have finished cancer treatment. The program combines structured exercise, nutrition counseling, and behavioral therapy. They compare it with a waitlist group to see how it affects cardiorespiratory fitness and body weigh…

Nausea and vomiting are common after bariatric surgery, and researchers want to know whether a simple cold compress can help. In this trial, 60 adults having weight-loss surgery receive a gauze-wrapped cold pack on the upper neck for five minutes, and care teams rate their nausea…

Researchers test a guided exercise program for people aged 60 and older recovering from lung cancer surgery. The program combines breathing exercises, shoulder training, and strength work, taught through videos and a manual. The trial measures how far participants can walk in six…

People with Parkinson's disease often struggle with walking, and their brains have trouble learning new movement skills. Researchers want to know if adding aerobic exercise or resistance exercise after gait training helps them learn and remember walking tasks better than gait tra…

Researchers compare two dental implant connection designs to see how each affects the bone around implants that hold lower dentures. Fourteen fully edentulous men, aged 45 to 60, receive two implants in the lower jaw, with one group getting internal tri-lobe implants and the othe…

This study follows 500 breast cancer patients who receive targeted radiation therapy after surgery to remove their tumor. The goal is to track side effects and quality of life over time. Researchers want to understand how well patients tolerate this treatment and how it affects t…

This study tests whether a personalized 4-week exercise program can improve quality of life and physical function in men with metastatic prostate cancer who are receiving radiation therapy. Eighty participants will either exercise or not, and researchers will track changes in wel…

Parents of children with complex medical conditions often feel unsure about managing their child's symptoms at home. This trial tests whether a mobile app with nurse support can help. Ninety-six parents receive either the app, which offers health checks, monitoring, education, an…

This study tests whether a special light therapy device can improve quality of life and movement for people with Parkinson's disease. About 350 participants who are already on standard Parkinson's medication will use the light at home. The goal is to see if adding this light ther…

Researchers test a 12-week structured exercise program for employees at a medical garment factory. The program includes 24 sessions with aerobic exercise, team games, and stretching. The study measures changes in productivity, performance reviews, job motivation, and quality of w…

This study looked at two oral chemotherapy drugs, Xeloda and UFT with folinic acid, in 89 people with advanced or metastatic colorectal cancer. The main goal was to see which treatment patients preferred after trying both. The study also checked how safe each drug was. Results he…

This study tests whether a program combining resistance training and a Mediterranean diet is practical and helpful for people with head and neck cancer undergoing radiation. Forty participants will receive supervised exercise sessions and pre-made meals, plus dietary coaching. Th…

This study looked at whether giving a specific type of numbing medicine (called PECS) during mastectomy surgery can lower the chance of having chronic pain 6 months later. It included 194 women having a breast removed, with or without lymph node removal or reconstruction. The goa…

This study looked at whether mandala art therapy (a structured coloring activity) can lower anxiety and increase comfort in people who received a kidney transplant. Eighty adult first-time kidney transplant recipients took part. The goal was to see if this simple, non-drug approa…

Researchers compare two ultrasound-guided nerve blocks to see which one better controls pain after video-assisted thoracoscopic surgery (VATS), a minimally invasive lung operation. The trial enrolls 46 adults scheduled for VATS. Participants receive either a serratus posterior su…

Researchers at the University of Oklahoma are testing a mobile health program designed to help adults receiving chemotherapy for metastatic breast or gynecologic cancer stay physically active. The program combines a wearable activity tracker, behavior change techniques, acceptanc…

Electromyography (EMG) and nerve conduction studies (NCS) check how nerves and muscles work, and many patients find them painful or stressful. Researchers are testing whether letting adults choose and listen to their own music during these tests lowers anxiety and pain compared w…

This trial tests whether an 8-week behavioral activation program can reduce cancer-related fatigue in women who have had surgery for stage I-III breast cancer. Participants are randomly assigned to receive the program plus usual care, or usual care alone. The study measures fatig…

This study tests a new way to give radiotherapy for men with intermediate-risk prostate cancer. The goal is to lower the dose to healthy parts of the prostate while boosting the dose to the tumor, using a special MRI-guided machine (MR-linac). Twenty men will take part to see if …

Researchers are testing whether oral N-acetylcysteine (NAC) can reduce signs of kidney tubular injury, oxidative stress, and inflammation in adults with non-severe leptospirosis. The trial enrolls 64 adults who have had fever for three to five days and a confirmed Leptospira infe…

Researchers are testing whether adding alpha-lipoic acid, an antioxidant supplement, to standard letrozole treatment helps infertile women with polycystic ovary syndrome ovulate and become pregnant. The trial enrolls 150 women aged 18 to 35 who are trying to conceive. Both groups…

This study tests whether a virtual exercise program can help children and young adults (ages 8-23) recover physical function and quality of life after a stem cell transplant. Participants will have twice-weekly, 30-minute online sessions with a physical therapist for 12 weeks. Th…

This pilot study tests a new group program called Move Healthier, designed to help people with overweight or obesity increase their exercise using cognitive and behavioral skills. The goal is to see if it boosts physical activity without raising the risk of disordered eating. Onl…

Researchers at Oregon State University are testing whether a brief, Spanish-language group program can reduce anxiety in Latino/a adults. The program teaches neuroscience-informed cognitive behavioral therapy over three weekly 90-minute sessions and asks participants to track the…

Researchers at Baylor College of Medicine are studying whether weekly art therapy can ease symptoms and improve quality of life for people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement, balance, and eye control. About 20 participants with …

Researchers are testing whether adjusting a patient's body position based on where the lung infection sits, combined with mechanical vibration on the chest, helps clear infected mucus better than routine position changes. The trial enrolls 384 adults in intensive care who need a …

This study tested whether a 12-week physical activity program could improve memory and attention in children who had radiation for brain tumors. Thirty-six kids aged 8–17 who finished radiation at least a year ago took part. Half started the program right away, while the other ha…

Researchers are studying whether a stoma self-care app, accessed through the LINE messaging platform, can help people with an enterostomy improve their self-care and quality of life. The study enrolls 50 adults who have a colostomy and can use a smartphone. It combines two models…

This study tested whether metformin, a common diabetes drug, along with a text-message activity program, could help people with pulmonary artery hypertension (PAH) walk farther and feel better day-to-day. 73 adults with PAH took part. The goal was to see if these interventions im…

Many people who move to a new country face depression, anxiety, stress, and trouble adjusting. This pilot study tests whether EMDR, a psychotherapy that uses guided eye movements to process distressing memories, can help when adapted for migration-related experiences. First-gener…

Pregnancy can worsen fibromyalgia symptoms like pain, fatigue, and poor sleep, affecting both mother and baby. This trial tests a community-based nursing program that combines weekly education sessions with twice-weekly exercise, including prenatal yoga and stretching, for pregna…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

Researchers at the Philippine Eye Research Institute studied a surgical technique called a sub-incisional pocket (SIP) for sealing the small corneal incisions made during cataract surgery. The study reviewed records from 35 adults who had routine phacoemulsification with a clear …

Researchers at the University of Oxford are studying an optimized rehabilitation program for children with spinal muscular atrophy (SMA) who are already on a stable disease-modifying treatment. The program adds goal-oriented rehabilitation, hands-on physiotherapy sessions, and a …

Researchers at Jagiellonian University are studying whether a supplement made from freeze-dried black raspberries and strawberries affects inflammation in people over 65 receiving treatment for colorectal cancer. About 70 participants take the anthocyanin-rich supplement for 21 d…

Researchers are testing whether cooling local anesthetic before injecting it into the tooth's pulp reduces pain during root canal treatment. The trial enrolls 40 people with painful, inflamed lower molars who need a root canal. Each participant receives the anesthetic at either c…

Researchers compare two drugs that reduce stomach acid, rabeprazole and omeprazole, in obese adults with gastroesophageal reflux. Participants receive a single dose of each drug, plus a placebo, and researchers measure stomach acid for 24 hours after each dose. The goal is to see…

Shots and blood draws cause pain and anxiety in children, and numbing creams take time to work. Researchers are testing a device that uses cold, vibration, and distraction to block needle pain. The trial compares this device with standard numbing cream in children aged 4 to 15 at…

Researchers are testing whether memantine, a drug already used for Alzheimer's disease, can ease symptoms or slow decline in people with frontotemporal dementia. The trial enrolls adults aged 45 to 75 with mild to moderate FTD and compares memantine against a placebo over one yea…

Researchers compare two physical therapy tools for children with Down syndrome: a virtual reality game system and a whole-body vibration machine. Forty children aged 6 to 10 who can stand independently join the study. Each child receives one of the two therapies for 30 minutes, t…

Newborns with complete bilateral cleft lip and palate often wear a custom molding appliance for a few months before surgery to bring the upper jaw segments closer together. This trial compares two versions: a vomer molding appliance and a conventional molding appliance. Researche…

Researchers are testing whether breathing extra oxygen during exercise training helps people with COPD who have normal oxygen levels at rest but drop low during activity. The trial enrolls 54 adults in a three-week inpatient rehab program. Participants cycle and walk while breath…

Researchers are testing an experimental drug called soticlestat in people with two rare genetic conditions: Dup15q syndrome and CDKL5 deficiency disorder. Both conditions cause frequent motor seizures that are hard to control. The trial enrolls about 20 participants who take one …

Whole-brain radiotherapy is a common treatment for cancer that has spread to the brain, but it often harms memory and thinking. This phase III trial tests whether adding the drug memantine and using a radiation technique that avoids the hippocampus, a brain area key to memory, ca…

People with type 2 diabetes often face higher rates of anxiety and depression than the general public. Researchers at Dasman Diabetes Institute are testing whether six weeks of guided breath awareness, practiced inside a pyramid-shaped structure, can reduce those symptoms. The pi…

Researchers are testing whether insulin eye drops help the cornea heal faster and reduce pain after corneal collagen cross-linking, a procedure used to treat keratoconus. In this paired-eye study, each participant receives insulin drops in one eye and standard drops in the other,…

Researchers at Rigshospitalet in Denmark are testing whether adults newly diagnosed with acute myeloid leukemia can safely measure their own blood counts and give themselves blood and platelet transfusions at home. The study trains and certifies 22 participants to use a home bloo…

Researchers are testing whether propranolol, a common blood pressure drug, can help people with fibromyalgia who also have post-traumatic stress disorder. Participants take propranolol and then read their own traumatic story about 75 minutes later, once a week for six weeks. The …

Researchers are testing whether nicotinamide riboside, a form of vitamin B3 sold as a supplement, can reduce immune system activation in people with mild to moderate psoriasis. The trial enrolls adults aged 18 to 80 who are not on biologic therapy. Participants take either the su…

Researchers are testing a digital picture-based tool that lets children with cancer report symptoms and distress during high-dose methotrexate treatment. The study includes children aged 5 to 17, their guardians, and healthcare professionals. Children use the tool to rate distres…

Researchers are testing whether a non-invasive brain stimulation technique called temporal interference stimulation can improve motor symptoms in people with early-to-mid-stage Parkinson's disease. The study compares stimulation while participants are on and off their usual Parki…

Researchers are testing a full-spectrum medicinal cannabis extract called NTI164, which contains 0.08% THC, in children with pediatric acute-onset neuropsychiatric syndrome (PANS). PANS causes sudden, severe obsessive-compulsive symptoms, restricted eating, and other psychiatric …

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

Researchers are examining skin cancer among people whose jobs involve long hours in the sun. The study uses national administrative and medical records to describe who develops these cancers, including age, sex, region, cancer type, and disability outcomes. The goal is to underst…

Researchers are following people with Leber congenital amaurosis caused by RPE65 gene mutations to see how their vision and retinas change over time. The study enrolls children and adults, ages 3 and older, who have this inherited retinal dystrophy. Participants undergo regular e…

Researchers reviewed hospital records from 1,441 patients to compare fungal infection rates during the SARS-CoV-2 pandemic and afterward. They calculated positivity rates for Candida and Aspergillus species and other fungi. The study examines whether infection control measures ch…

This study investigates whether the unique bacteria found inside digestive system tumors can help predict how well a patient will respond to neoadjuvant therapy (chemotherapy before surgery). Researchers will analyze tumor samples from 90 adults with pancreatic, gastric, colorect…

This study will test whether an artificial intelligence chatbot can encourage men who have sex with men in Kuala Lumpur, Malaysia to get tested for HIV. 80 participants will be randomly assigned to receive either automated chatbot messages with HIV testing information or standard…

Researchers want to know whether a specific brain wave, called mismatch negativity, can serve as a marker for problems locating sound. They will compare three groups: people with normal hearing, people with single-sided deafness, and people with a cochlear implant in one ear. Par…

This study looked at how two prostate cancer drugs, darolutamide and enzalutamide, affect thinking and memory in men with advanced prostate cancer. About 111 men took one of the two drugs and completed computer-based cognitive tests over time. The goal was to see if one drug caus…

Children with growth hormone deficiency often need daily injections, which can be hard to keep up with. Researchers in Belgium and Luxembourg are asking families in the BELGROW registry to fill out a questionnaire about whether they would consider switching to long-acting growth …

This study tests a new way to find the first lymph node (sentinel node) during breast cancer surgery. Instead of using the usual armpit hairline as a guide, doctors will use ultrasound to mark the exact spot. The goal is to see if this leads to a smaller cut, less tissue damage, …

This study tests whether a new, high-field 3T MRI technique can more accurately pinpoint the subthalamic nucleus — a key brain area targeted during deep brain stimulation (DBS) for Parkinson's disease. Researchers will compare images from the new method with standard 1.5T MRI in …

This early-stage study tests a new formulation of the cancer drug HRS-2189 in 28 healthy adults aged 18-45. The goal is to compare how the body absorbs the new versus the old tablet version and to check for safety. Participants will take a single dose of each formulation in rando…

Children with congenital heart disease often need a breathing machine after surgery, and the pressure it creates can affect blood flow to the brain. This study compares conventional ventilation with NAVA, a mode that works with the child's own breathing signals, in 30 children re…

This study looked at whether obesity increases the body's production of oxalate, a substance that can lead to kidney stones. 58 adults without a history of kidney stones ate a special low-oxalate diet for 4 days and provided urine samples. Researchers measured oxalate levels to s…

This completed Phase 4 trial studied how sugammadex, a drug that reverses muscle relaxants, works in 48 patients undergoing laparoscopic surgery. Researchers measured drug levels in the blood and how quickly patients recovered muscle function. The study focused on patients with a…

Researchers in the Ile-de-France region are following adults hospitalized with COVID-19 or suspected of having it. They collect blood samples at admission and, for severe cases, at several later points, and they track health outcomes over time. The goal is to identify which facto…

This study is looking at whether tracking tiny bits of tumor DNA in the blood can help predict if breast cancer will come back after chemotherapy and surgery. Researchers will take blood samples from 180 people every 6 months for 5 years. The goal is to see if these DNA clues can…

Researchers are comparing serious health events, such as death and unplanned hospital stays, between elderly residents of retirement homes and long-term care units who received a COVID-19 vaccination and those who did not. The study includes about 3,300 residents in the Ile-de-Fr…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

Researchers compare two operations for pancreatic tumors: partial removal of the pancreas and duodenum versus total removal of the pancreas. They analyze anonymized hospital records from 2013 to 2022 for about 3,600 adults in Switzerland. The study asks whether total removal is l…

Researchers are studying whether certain immune substances in the blood are linked to physical and mental abilities in people with relapsing-remitting multiple sclerosis. The study includes 20 adults aged 19 to 45 with mild disability. Participants give blood samples, and researc…

This study looked at 40 people having both wisdom teeth removed, two weeks apart. Researchers measured two natural chemicals in the blood—serotonin and kynurenic acid—before and after surgery to see if they relate to pain and anxiety. The goal was to better understand how these c…

This study compares a new formulation (AJU-G721) of a drug used for benign prostatic hyperplasia (BPH) to the original version (G721R) in healthy adult men. The goal is to see if the two versions are absorbed and processed by the body in the same way. Participants receive a singl…

This study explores whether a special PET/MRI scan can predict how well esophageal cancer responds to chemotherapy and radiation given before surgery. Researchers will scan 121 patients during treatment and compare the images with the actual tumor response seen after surgery. The…

Researchers at Ghent University Hospital are studying whether MRI scans combined with computer models can measure the pressure inside tumors. High pressure in tumor tissue can block cancer drugs from reaching their target. The study enrolls 22 patients with pancreatic cancer or w…

This study looked at whether being more physically active, measured by daily steps, helps rectal cancer patients respond better to chemotherapy and radiation before surgery. About 120 participants wore smartwatches to track their steps, heart rate, and sleep. The goal was to see …

This study used brain imaging to understand how Parkinson's disease changes the brain over time. Researchers compared people with definite or possible Parkinson's to healthy volunteers. Participants had up to six visits over nine years, including MRI scans and symptom checks. The…

This completed study looked at 31 people with early-onset Parkinson's disease (starting before age 50) and their family members to find genetic causes. Researchers collected blood and skin samples to study DNA and create cell lines. The goal was to better understand which gene mu…

This study gives questionnaires to patients, interpreters, and healthcare professionals to understand how language and cultural differences impact care for women with gynecologic cancer. The goal is to identify barriers and improve the patient experience. About 45 people will tak…

Researchers are studying a technique to remove fewer lymph nodes in women with breast cancer that has spread to the lymph nodes and who receive chemotherapy before surgery. The approach uses a clip placed in the affected node to guide surgeons during a selective axillary dissecti…

This study tested whether training local community members as wellness coaches could help African American adults in economically disadvantaged areas manage their weight. Researchers recruited and trained coaches to lead a 12-week group lifestyle program. The goal was to see if t…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

This study compares three ways of teaching midwifery students about preeclampsia and eclampsia: a digital game, a simulation, and traditional lectures. The goal is to see which method boosts knowledge, motivation, and attitude the most. 120 fourth-year midwifery students will tak…

This study uses advanced brain imaging and non-invasive stimulation to understand how the brain changes in the early stages of Parkinson's disease. Researchers will compare people with early Parkinson's (not yet on medication) to healthy volunteers of similar age and sex. The goa…

This study looked at 85 people with tremor conditions like Parkinson's disease, essential tremor, and dystonia, plus healthy volunteers. Researchers used tests like brain scans, electrical recordings, and movement tasks to learn how the brain controls movement and what goes wrong…

This study follows 61 people who previously used the REVISYON SDS 100 device for mild-to-moderate cataract. Researchers will check for side effects and measure vision changes over about 20 months. No new treatment is given; the goal is to see if the device stays safe and works we…

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…

Researchers are studying whether daily step counts and other smartwatch measurements can predict which cancer patients will be readmitted to the hospital after discharge. Adults who have just left an oncology ward wear a Huawei smartwatch for 30 days to track steps, heart rate, a…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…

This completed study followed 26 adults aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and visual function. The goal was to better understa…

Researchers are studying whether delays in follow-up colonoscopies after certain polyp findings raise the risk of advanced growths or colorectal cancer. The study looks at medical records of adults aged 45 to 80 who had serrated lesions or high-grade dysplasia found during a colo…

Researchers are studying how traditional and non-traditional heart risk factors relate to cholesterol levels in hospitalized Mexican adults. The study focuses on HDL cholesterol, often called good cholesterol, and how it behaves in people who smoke or have certain dietary habits.…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

Researchers are studying how two types of ulcerative colitis treatment, tofacitinib and anti-TNF drugs, affect platelet function and the body's clotting system. The trial enrolls adults with ulcerative colitis and compares blood and tissue samples before and after they start trea…

Researchers want to understand what patients with early oesophageal cancer value most when deciding whether to have major surgery. The study uses interviews and a choice experiment with about 118 people under care for Barrett's, dysplasia, or oesophageal cancer. Participants answ…

This study looks at whether using a mobile health app (called Penelope) is a cost-effective way to manage high blood pressure disorders during pregnancy. About 250 pregnant women at risk for conditions like preeclampsia will either use the app or track their health on paper. Rese…

This study collects videos and images from 1,650 adults having a camera test of their stomach or bowel (endoscopy). Researchers will use these recordings to see how well artificial intelligence (AI) can spot early signs of cancer. The goal is to improve detection and help doctors…

This study checks for muscle loss (sarcopenia) in 25 women with advanced ovarian cancer before they start chemotherapy. Using CT scans, researchers want to see how common this condition is and if it affects treatment timing. The goal is to better understand how muscle health rela…

This study looked at whether a special PET scan (FDG-PET) can detect early whether breast cancer is responding to chemotherapy. 63 women with breast cancer had a PET scan before and after their first chemo cycle. The goal was to see if the scan could tell responders from non-resp…

Researchers are studying people who have surgery for cervical radiculopathy, a condition where a pinched nerve in the neck causes arm or hand weakness. The study follows about 2,000 patients to see how many recover full strength and whether factors like how severe the weakness wa…

Researchers are studying whether protein patterns in the blood can predict which people with esophageal cancer will respond completely to combined chemotherapy and radiation. The trial enrolls about 50 adults with invasive esophageal cancer who receive standard radiochemotherapy.…

This study followed 76 children with brain tumors to learn how radiation therapy affects their quality of life, thinking, and body functions over time. Researchers collected blood, urine, and MRI scans before and after treatment, along with tests of memory, behavior, vision, and …

This completed study looked at how well different eye tests can track changes in retinitis pigmentosa (RP), a group of blinding eye diseases. Researchers tested 49 people with RP and healthy volunteers using exams like vision tests, retinal imaging, and electrical signal recordin…

This study looked at whether high-intensity interval training (HIIT) or weight-loss surgery can reduce the risk of nerve damage (peripheral neuropathy) in people with obesity. About 140 adults who were candidates for bariatric surgery took part. Researchers measured nerve health …

This study looked at the emotional and practical challenges faced by patients with incurable cancer and their caregivers when planning to return home for end-of-life care. Researchers measured how each person perceived the burden, using surveys and statistical analysis to find fa…

This completed study used a 3D camera system called stereophotogrammetry to take pictures of the torso in healthy volunteers and people with scoliosis, chest wall deformities, or obesity. The goal was to refine the imaging technique, not to test a treatment. About 199 participant…

Researchers are studying blood and tumor tissue from people with squamous cell cancer of the larynx, pharynx, or oral cavity who have no history of smoking, heavy drinking, or workplace exposure to substances like asbestos or wood dust. The goal is to learn how DNA changes and bi…

Researchers are surveying people in Thailand who have chronic hepatitis B to find out how many also carry hepatitis D, a virus that can make liver disease worse. The study focuses on groups at higher risk, including people who inject drugs, men who have sex with men, prisoners, a…

This completed study looked at blood and tumor samples from 66 women with breast cancer who were about to receive chemotherapy before surgery. Researchers searched for unique protein patterns that might show whether the tumor would shrink with treatment. The goal was to find a wa…

This completed Phase 2 trial looked at whether the sentinel lymph node technique—a less invasive way to check if cancer has spread—works for women with multifocal breast cancer (more than one tumor in the same breast). 216 women with early-stage, node-negative multifocal breast c…

This study followed 150 people with solid tumors who were starting immunotherapy (immune checkpoint inhibitors) as part of their regular care. Researchers collected data on side effects and asked patients to fill out questionnaires before each treatment. The goal was to better un…

This study looks at a new, less invasive way to monitor blood flow during heart ablation procedures. Doctors will use a special device to track heart function beat-by-beat. The goal is to see if this method helps improve care for 27 adult patients having heart ablation.

Researchers surveyed 751 high school students aged 15 to 17 in Istanbul to see how obesity awareness relates to weight status and daily habits. Students answered questionnaires about diet, physical activity, screen time, sleep, and family background, and researchers measured thei…

This study tests whether wearable sensors and caregiver questionnaires can capture the behavioral signs of apathy in people with dementia during daily life. Patients with Alzheimer's or frontotemporal dementia and their caregivers wear a sensor bracelet for 28 days, while caregiv…

Lidocaine is often injected through an existing epidural catheter to numb women for urgent cesarean delivery, and the drug can cross the placenta to the baby. Researchers at multiple hospitals are measuring lidocaine levels in paired umbilical cord blood samples collected right a…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study created a registry of medical records from women with inborn errors of metabolism—rare conditions that affect how the body turns food into energy. Researchers collected data from past or current pregnancies and followed babies for one year after birth. The goal was to …

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This study aims to understand why testicular cancer sometimes runs in families. Researchers will collect DNA samples and medical information from about 750 people in families with multiple cases of testicular cancer. No treatment is given; the goal is to find genes that increase …

This completed study looked at why some people develop scarring in their kidneys, including rare diseases like FSGS and a mysterious form of chronic kidney disease affecting farm workers. Researchers collected blood, urine, and kidney tissue from 537 participants to better unders…

This study investigated whether environmental exposures during military service increase the risk of developing myositis, a rare autoimmune disease that attacks muscles. Researchers compared 37 military personnel with and without myositis using questionnaires and blood samples. N…

This completed study enrolled 377 individuals and families with a high risk of breast or ovarian cancer due to known or suspected genetic factors. Researchers collected medical records, questionnaires, and biological samples to better understand the disease's natural history and …

This study looked at 629 children in California to see if exposure to pesticides at home or from nearby farms is linked to childhood leukemia. Researchers collected dust from carpets and vacuum cleaners and mapped crops near homes. The goal was to measure chemical levels and see …

Dengue has become a recurring illness on Reunion Island, and repeat infections tend to be more severe. Researchers are following 258 adults and children who arrive at two island hospitals with confirmed or suspected dengue, collecting blood samples and health questionnaires over …

This study looked at whether standard radiation treatment for cancer that has spread to the brain causes changes in thinking skills like memory and attention. 35 adults with brain metastases received radiation and took tests and surveys before and after treatment. The goal was to…

This study followed 775 healthy children aged 2-9 in Cambodia over three years to learn how mosquitoes spread dengue and other viruses. Researchers took blood samples every wet and dry season to check for past or current infections. The goal was to understand why young children g…

This study tests a new way to choose treatments for people with multiple myeloma or plasma cell leukemia that has returned or stopped responding to standard therapy. Researchers use a lab test that checks many drugs at once, along with genetic information, to find which drug or d…

This study looked at how forced and voluntary exercise change brain signals and thinking skills in 25 people with Parkinson's disease who have a brain pacemaker (DBS). Participants did one session of each exercise type while off their usual medications and DBS. The goal was to fi…

This study looked at how bacteria from the gut might travel to the liver and make liver disease worse in people with hepatitis C. Thirty adults with stable liver disease took part. Researchers used blood tests, MRI scans, and liver tissue samples to measure bacterial movement and…

This study tested new screening methods like MRI, duct lavage, and PET scans in 200 women with BRCA gene mutations who are at high risk for breast cancer. The goal was to see if these tools can find cancer earlier than standard mammograms. Participants were followed for three yea…

This completed study looked at how to best find and manage tumors in people with Zollinger-Ellison syndrome, a rare condition that causes too much stomach acid. Researchers used imaging tests and tissue samples to locate tumors and check for a related genetic condition called MEN…

Researchers are studying whether adults with Dunnigan lipodystrophy, a rare genetic condition that changes how the body stores fat, have higher levels of inflammation than people without it. The trial enrolls 64 non-diabetic adults on Reunion Island, including those with the cond…

Researchers at Centre Oscar Lambret are studying how immune cells get inside breast and colon tumors. They will analyze stored tumor samples from about 70 patients treated between 2005 and 2007, looking at genes and proteins on blood vessel cells that may control this process. Th…

This study tested whether two light-based technologies, fNIRS and DCS, can safely measure brain activity in children with rare neurocognitive disorders like Niemann-Pick disease and Smith-Lemli-Opitz syndrome. 73 participants, including healthy volunteers, wore a cap with lights …

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

This completed study looked at how genetic differences might change the way immune cells in the lungs respond to environmental triggers like dust and germs. Researchers collected blood and lung samples from 20 healthy adults to compare cell function between people with different …

This study checked how many organ transplant recipients in the U.S. have antibodies to the hepatitis E virus, which can become chronic in people with weakened immune systems. Researchers enrolled 447 adults who had a liver, kidney, or small bowel transplant or were on a waiting l…

Researchers are testing two ways to train VA primary care clinicians to hold goals of care conversations with veterans who have serious illnesses such as cancer, heart failure, or dementia. One approach gives clinicians written materials and online training. The other adds team f…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study followed 50 adults with a C9ORF72 gene mutation that can cause ALS or frontotemporal dementia. Over three years, researchers measured changes in strength, thinking, memory, and behavior using brain scans, spinal fluid tests, and other assessments. The goal was to under…

This study looks at whether closely following a standard enhanced recovery after surgery (ERAS) protocol affects nutritional status in 120 adults undergoing lung cancer surgery. Researchers will measure nutritional risk and a nutritional index before surgery and two days after, a…

This study in Bauchi, Nigeria, is testing whether giving free Oral Rehydration Salts (ORS) and zinc directly to homes can increase how often these treatments are used for children under 5 with diarrhea. Over 100,000 children are taking part, with some areas receiving the medicine…

This completed study analyzed genetic material from 1,340 patients with lymphoma, leukemia, or multiple myeloma. Researchers used DNA microarrays and other tools to find new molecular subtypes that could explain why some patients respond better to treatment than others. The goal …

This study looked at 190 HIV-positive women starting HIV medicines to see how often herpes virus symptoms appear or get worse. Researchers collected blood, urine, and vaginal samples over a year to track virus activity. The goal was to understand why some women have herpes flare-…

This study follows up on over 32,900 people from Linxian, China, who took part in a nutritional trial between 1985 and 1991. Researchers are tracking cancer cases and deaths to see if earlier vitamin and mineral supplements had lasting effects. They are also collecting blood samp…

This completed study looked at genetic factors that might increase the risk of esophageal and stomach cancers. Researchers collected DNA samples from over 7,700 people, including patients with cancer and healthy individuals from high- and low-risk areas in China. The goal was to …

This completed study analyzed leftover tissue samples from 130 people with lymphoma or related conditions. Researchers measured levels of histone and other proteins to find patterns linked to different lymphoma types. The goal was to better understand the biology of these cancers…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This completed study enrolled over 50,000 adults aged 40-75 in Iran's Golestan Province to understand why esophageal cancer is so common there. Participants filled out lifestyle and diet questionnaires and provided blood, urine, hair, and nail samples. Researchers are analyzing f…

Researchers want to know how common a BRCA2 gene mutation is among people diagnosed with breast cancer on Reunion Island. Earlier work found that more than half of patients there with a BRCA mutation carry a variant specific to the island's population. This study collects blood s…

This study aims to find the genetic causes of hereditary hearing loss and balance disorders. Researchers will study families with these conditions, collecting medical history, blood or cheek swabs, hearing and balance tests, and sometimes scans. The goal is to identify genes and …

This study collected information from 733 people with a personal or family history of hereditary stomach cancer. The goal was to better understand how these cancers develop and what genes are involved. Participants provided medical history, blood samples, and genetic testing. The…

This study looks at how the severity of carpal tunnel syndrome relates to ultrasound images of the nerve, nerve conduction tests, hand grip strength, and pain sensitivity. Researchers will assess 90 adults with the condition using these measures during a single visit. The goal is…

This study tested whether three new diagnostic tools could help doctors pick the best antibiotic faster for ICU patients with Gram-negative bloodstream infections. Researchers compared standard lab methods to the new tests in 100 patients. The goal was to see if more patients got…

Researchers want to know whether the amount, location, and behavior of body fat contribute to two hormone conditions in women: hypothalamic amenorrhea, where menstrual periods stop, and polycystic ovary syndrome (PCOS). The study enrolls 50 women across five groups, including ath…

This study followed 78 people with GNE myopathy, a rare genetic disease that causes progressive muscle weakness starting in young adulthood. Researchers collected medical history, blood samples, and muscle function tests over up to two years to understand how the disease progress…

This study tested a computer-assisted method for people to self-administer alcohol intravenously, aiming to achieve precise blood alcohol levels for research. 229 healthy volunteers aged 21-45 took part in sessions where they could give themselves alcohol infusions using a comput…

This study followed 17 adults with neurofibromatosis type 1 (NF1) over two years to learn how their skin tumors (dermal neurofibromas) grow and change. Researchers used special cameras and skin biopsies to measure tumor growth and look for genes that might influence it. The goal …

This study measured how common pulmonary hypertension (high blood pressure in the lungs) is in adults with sickle cell anemia. Nearly 1,000 participants had heart ultrasounds and blood tests, then were contacted by phone for up to 3 years to track their health. The goal was to un…

Anesthesiology residents in Turkey face long hours and high-stakes work, and researchers want to measure how many of them are experiencing burnout. The study surveys 154 residents using the Maslach Burnout Inventory, a standard questionnaire that scores emotional exhaustion, deta…

This study looks at people who have severe allergic reactions (anaphylaxis), especially when the cause is unknown. Researchers will do blood tests and bone marrow biopsies to find genetic or molecular clues. The goal is to understand what goes wrong in the body, not to test a new…

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This study looked at whether offering genetic testing to all young adults with cancer (ages 18-39) is better than only testing those who meet certain guidelines. About 749 participants were randomly assigned to either universal testing with a broad gene panel or standard testing …

This completed study looked at how lean and obese individuals respond to thirst and water deprivation. Researchers gave 75 healthy men a high-salt infusion and a 24-hour water fast, measuring their thirst, hormone levels, and water intake. The goal was to understand if body fat a…

Many female athletes eat less carbohydrate than they need. Researchers want to know whether showing teen athletes their own metabolic test results changes their attitudes about carbohydrate more than a standard nutrition lesson does. Girls aged 13 to 19 at a sports academy join e…

Researchers at a large hospital in Seoul reviewed records from nearly 33,000 adults who had curative-intent surgery for one of seven cancers in the abdomen or pelvis: pancreatic, gastric, rectal, cervical, endometrial, kidney, or prostate. They grouped patients by whether they re…

This study gathered information from 326 adults with rare central nervous system tumors, such as medulloblastoma and ependymoma. Participants completed surveys about their symptoms, treatments, and lifestyle, and provided a saliva sample for genetic analysis. The goal was to lear…

This study looked at people with three rare genetic conditions—xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD)—that affect the body's ability to repair DNA. Researchers examined 709 participants to understand how these defects relate to cancer ri…

This study looks at how different meals before exercise affect amino acid levels in adults with phenylketonuria (PKU). Ten participants will try water, carbohydrates, or protein before doing aerobic and resistance exercises. Researchers will measure changes in blood amino acids t…

This study searched for genetic factors that may cause focal segmental glomerulosclerosis (FSGS), a kidney disease that can lead to kidney failure. Researchers compared DNA from 616 people, including African-Americans with FSGS, African-Americans with HIV but no FSGS, and non-Afr…

This study collected and stored biological samples from nearly 10,000 tin miners in China who are at high risk for lung cancer due to workplace exposures. The goal is to use these samples to discover early markers of the disease, which could lead to better screening and preventio…

This study looked at how people with and without non-alcoholic fatty liver disease (NAFLD) process food. Researchers monitored 53 adults over two days, measuring metabolism, blood, and urine after meals. The goal was to find differences that might explain why fat builds up in the…

This study looked at 805 blood donors who tested positive for hepatitis C virus (HCV) to learn how the virus spreads and affects health over time. Researchers collected blood samples and health information to track infection and liver disease. The goal was to better understand HC…

This study follows people who have or had anthrax, those exposed, and healthy vaccinated volunteers to learn how the body fights the disease. Researchers will track symptoms, immune responses, and long-term health for up to 2 years. The goal is to better understand anthrax and im…

This completed study investigated how eating behaviors and food preferences, especially for high-fat foods, contribute to obesity. Researchers studied 669 healthy adults, including Pima Indians (who have high obesity rates) and Caucasians, using questionnaires and food intake mea…

Researchers are studying whether the lining of the small intestine shows signs of inflammation in people with Familial Mediterranean Fever (FMF), a genetic condition that causes recurring fevers and pain. The study compares intestinal biopsy samples from about 30 adults with FMF …

Researchers in Taiwan are building a nationwide registry of people diagnosed with gastrointestinal stromal tumors, a rare cancer of the digestive tract. The study collects details on how the tumors are found, their stage, the treatments patients receive, and how they fare over ti…

Sepsis and septic shock cause organ failure and death, and doctors need simple ways to flag the patients most at risk. Researchers at Benha University Hospital followed 60 adults with sepsis or septic shock in a surgical intensive care unit for 28 days. They compared two ratios c…

Researchers at the University of Malaya are studying how COVID-19 affects muscle loss and strength in critically ill patients. They will compare quadricep muscle thickness and cross-sectional area, along with handgrip and knee extension strength, between COVID-19 and non-COVID-19…

Researchers want to learn which molecules on cancer cells the immune system attacks when checkpoint inhibitor drugs work well. They collect tumor and blood samples from adults with solid tumors who respond to these drugs, either during treatment or after surgery. The team then se…

Researchers at the University of California, San Francisco are studying how the brain processes rewards in people with early-onset schizophrenia, major depressive disorder, post-traumatic stress disorder, or gambling disorder, compared with healthy volunteers. Participants comple…

Researchers at Nantes University Hospital are studying whether nerves feel stiffer in people with three rare peripheral neuropathies: CIDP, CMT1a, and anti-MAG neuropathy. They use ultrasound shear wave elastography to measure nerve stiffness in 36 participants aged 18 to 65 and …

Idiopathic hypersomnia causes severe daytime sleepiness that differs from narcolepsy, yet researchers do not know what drives it. This study uses 64-electrode EEG to look for local slow waves, a sign of sleep-like activity in parts of an otherwise awake brain, while participants …

Researchers are testing whether data from a commercial smartwatch and a mobile app can help personalize treatment for Parkinson's disease. The study enrolls 54 adults with Parkinson's who take levodopa and experience daily motor fluctuations. Participants wear a Garmin Vivosmart …

Researchers are following 110 people aged 1 to 65 who have homocystinuria caused by a missing or faulty CBS enzyme. The study observes how the condition changes over time under standard care, without testing any new treatment. Participants give blood samples, complete quality-of-…

Breast cancer surgery often involves removing lymph nodes from the armpit, which can lead to lasting arm swelling and reduced arm function. This study follows 258 breast cancer patients who have this node removal and compares two groups: those whose surgeons preserve small vein b…