Disease by etiologic mechanism

Researchers compare two topical treatments for plantar warts: hydrogen peroxide 40% applied once weekly and salicylic acid 40% applied daily. The trial enrolls 70 people aged 12 and older with clinically diagnosed plantar warts. The main goal is to see how many participants achie…

Researchers are testing AMP-101, an experimental gene therapy, in people with DOK7 congenital myasthenic syndrome, a rare inherited disorder that causes muscle weakness and exercise intolerance. About 4 participants with moderate to severe DOK7 CMS will receive a single intraveno…

Researchers are testing a minimally invasive laser procedure to treat chronic pilonidal sinus, a painful condition near the tailbone. The trial enrolls adults with sinus tracts between 2 and 9 centimeters, excluding those with acute abscesses or prior surgery. During the procedur…

Researchers are testing a conditioning regimen built around thiotepa before a haploidentical, or half-matched, stem cell transplant in people aged 50 and older with severe aplastic anemia. The regimen also includes busulfan, fludarabine, anti-thymocyte globulin, and basiliximab, …

Newborns who suffer a stroke or oxygen loss around birth can develop cerebral palsy and other lifelong disabilities, and no treatment can repair the damage. Researchers at UMC Utrecht are testing whether a single dose of bone marrow-derived mesenchymal stromal cells, sprayed into…

Researchers are testing an experimental cell therapy called HS-IT101 in people with advanced non-small cell lung cancer. The treatment uses tumor-infiltrating lymphocytes (TILs), immune cells taken from the patient's own tumor, multiplied in the lab, and given back. Before receiv…

Researchers are testing an experimental therapy called SNC116 in adults with B-cell acute lymphoblastic leukemia that has returned or stopped responding to treatment. The early-stage study enrolls about 28 people and focuses on safety, side effects, and how the body processes the…

Researchers are testing CHANK-101, a therapy made from a patient's own natural killer (NK) cells, in adults with glioblastoma that has returned after standard treatment. The study enrolls 60 participants who receive intravenous infusions of these cells every two weeks for up to 1…

Researchers are testing an experimental therapy called SRN-101 in adults with recurrent high-grade glioma, an aggressive brain cancer that has returned after standard treatment. Participants receive SRN-101 directly into the tumor before planned surgery to remove it. The trial's …

Researchers are comparing two ways of performing robotic surgery to remove stomach cancer: a single-port approach and a standard multi-port approach. The trial enrolls 212 adults with stomach cancer that can be removed with distal gastrectomy. The main question is whether the sin…

This phase 3 trial tests whether adding sintilimab, an immunotherapy drug, to chemotherapy before surgery helps people with early-stage oral squamous cell carcinoma. Participants are adults aged 18 to 75 with cT2N0M0 oral cancer that can be removed by surgery. Half receive sintil…

Researchers test a new surgical approach for thyroid cancer that has invaded the windpipe. They replace the affected section with a preserved aortic graft supported by a silicone stent. The goal is to remove all cancer and improve survival. The trial includes patients whose cance…

Researchers are testing an experimental cell therapy called CT1190B in adults with large B-cell lymphoma that has returned or stopped responding to treatment. The trial enrolls up to 68 people aged 18 to 75 and gives the therapy by intravenous infusion. The main goals are to chec…

Researchers are testing whether a combination of two long-acting HIV antibodies and a low dose of the cancer immunotherapy nivolumab can help people with HIV control the virus without antiretroviral therapy. The trial enrolls 90 adults whose HIV is already well suppressed on stan…

Researchers test a one-time gene therapy infusion in children and adults with Sanfilippo syndrome (MPS IIIB), a rare inherited disease that damages the brain and body. The therapy delivers a working copy of the NAGLU gene to help the body make an enzyme that is missing or faulty.…

Researchers are testing CHT101, an experimental CAR-T cell therapy made from donor cells, in adults with T-cell or B-cell blood cancers that have come back or stopped responding to treatment. The therapy targets CD70, a marker found on these cancer cells. The Phase I trial aims t…

Researchers are testing a new dengue vaccine called VLPDEN-02 in 42 healthy adults who have never had a flavivirus infection. The vaccine combines four virus-like particles, one for each dengue virus type, with an adjuvant to boost the immune response. Participants receive three …

Researchers are testing three experimental malaria vaccines (LYB014, LYB017, and LYB027) in healthy adults aged 18 to 50. Participants receive either a low or high dose of one vaccine combined with an immune-boosting adjuvant, or the adjuvant alone as a comparison. The trial trac…

This early-stage trial will test a new HIV vaccine in 22 infants who were exposed to HIV during birth but are not infected. The vaccine is designed to train the immune system to recognize and fight HIV. The main goal is to see if the vaccine is safe and whether it triggers an imm…

This study tests a new type of COVID-19 booster vaccine given as a nasal spray. The vaccine uses a weakened live virus to train the immune system, potentially offering stronger protection in the nose and throat where the virus enters. Researchers are enrolling 80 healthy adults a…

This trial is testing whether an experimental mRNA vaccine can safely reduce moderate-to-severe acne in adolescents aged 12 to 17. Participants receive either the vaccine at different dose levels or a placebo, and researchers monitor safety and changes in facial acne lesions. The…

This Phase 1 trial tests experimental mRNA vaccines designed to protect against many types of influenza A by targeting a stable part of the virus. Healthy adults aged 18 to 59 receive one or two doses of the vaccine candidates, alone or in combination. The study checks for side e…

This study tests a new COVID-19 vaccine (LUNAR-COV19) in 56 adults who received a blood stem cell transplant within the past year. These patients often have weaker immune responses to standard vaccines. The new vaccine uses a self-amplifying mRNA that may produce a stronger and l…

Researchers are testing an experimental tuberculosis vaccine called VIR-1778 in healthy adults who do not have HIV. The vaccine uses a weakened form of human cytomegalovirus to deliver seven TB proteins to the immune system. The trial aims to see if VIR-1778 is safe and whether i…

Researchers are testing whether a doctor can remotely steer a robotic bronchoscope over a 5G network to freeze small lung tumors from inside the airway. The study enrolls about 15 adults with non-small cell lung cancer or controlled metastatic lung tumors, each no larger than 3 c…

Researchers are testing whether combining albumin-bound paclitaxel with gemcitabine helps people with metastatic pancreatic cancer who have not yet received systemic treatment. The study enrolls about 59 adults aged 18 to 75 with confirmed metastatic pancreatic adenocarcinoma. Pa…

This study tests whether adjusting chemotherapy doses for each patient can improve outcomes after a stem cell transplant for blood cancers caused by a RUNX1 gene mutation. Up to 98 people aged 4 to 70 with these cancers will receive a transplant from a half-matched donor. The goa…

Researchers are testing a new oral drug called JNJ-101556143 in people with metastatic prostate cancer that has stopped responding to hormone therapy. The trial aims to see if the drug can shrink tumors or make them disappear. About 100 participants will receive the drug, and doc…

This study tests a combination of two experimental drugs, obrixtamig and ZL-1310, designed to help the immune system fight cancer. It is for adults with advanced small cell lung cancer or other neuroendocrine cancers. The trial has two parts: the first finds a safe dose of the tw…

This phase 1 trial is testing an experimental drug called ATG-201 in adults with systemic lupus erythematosus, systemic sclerosis, or Sjögren's disease. ATG-201 is designed to bind to specific proteins on immune cells, potentially quieting the overactive immune response that driv…

Researchers compare two radiotherapy schedules for women who had breast reconstruction after mastectomy for breast cancer. One schedule gives larger daily doses over 3 weeks; the other gives smaller daily doses over 5 weeks. The trial checks whether the shorter schedule controls …

Researchers are testing whether CM336, a bispecific antibody that helps the immune system target myeloma cells, works safely and effectively when combined with daratumumab and lenalidomide. The trial enrolls adults aged 18 to 75 with newly diagnosed multiple myeloma who are not p…

This phase III trial will enroll 854 Hispanic adults who smoke and want to quit. Participants will use the iCanQuit smartphone app, which teaches skills to manage cravings and prevent relapse. Half will also receive nicotine replacement therapy (gum, patch, or lozenge) to ease wi…

Researchers are testing an experimental drug called 7MW3711 against the standard chemotherapy docetaxel in people with locally advanced or metastatic squamous non-small cell lung cancer. All participants have already received platinum-based chemotherapy and immunotherapy, and the…

Researchers are testing whether adding the experimental drug RC148 to platinum-based chemotherapy helps people with advanced non-squamous non-small cell lung cancer live longer without their disease worsening, compared with tislelizumab plus the same chemotherapy. The trial enrol…

Researchers are testing a combination of three drugs, belantamab mafodotin, cevostamab, and pomalidomide, in adults whose multiple myeloma has returned after at least two prior treatments. The phase 1b trial aims to find the best dose and see how well the combination controls the…

This trial tests a new approach for people with solid tumors that have returned or not responded to standard treatments. The therapy uses the patient's own myeloid cells, a type of immune cell, which are genetically modified in a lab to produce a cancer-fighting protein called IL…

Researchers are testing an experimental antibody drug called zuberitamab in people with primary membranous nephropathy, a kidney condition that causes protein to leak into the urine. The trial compares zuberitamab injections with cyclosporine, a standard immune-suppressing drug, …

This trial tests whether B-OK bottles, which use beads to visually explain how HIV affects health and how treatment lowers viral load, can help people with HIV stick to their medication. Researchers will roll out the bottles across HIV case management agencies in Philadelphia and…

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

This trial tests a medical device that has not been approved or cleared by the U.S. FDA. Researchers want to learn whether the device is safe and whether it can help people with a specific condition. Participants receive the device as part of the study, and the team monitors thei…

Many people who lose weight with GLP-1 drugs like semaglutide or tirzepatide face a choice: stay on the drug indefinitely or stop and risk regaining the weight. This pilot trial compares three approaches in 60 adults with obesity who have reached or nearly reached their target we…

Researchers are testing whether a five-fraction course of stereotactic body radiotherapy (SBRT) works as well as the standard 20-fraction radiotherapy for men who need radiation after prostate cancer surgery. The trial enrolls 206 adults and randomly assigns them to either the sh…

This trial is testing whether a targeted therapy called raludotatug deruxtecan (R-DXd), given alone or with bevacizumab, can help people with newly diagnosed advanced ovarian cancer live longer without their cancer growing. Participants have already completed first-line platinum-…

Researchers are testing whether a combination of rituximab, pirtobrutinib, lisaftoclax and liposomal mitoxantrone can shrink tumors in adults whose chronic lymphocytic leukemia has transformed into the aggressive cancer Richter syndrome. The trial plans to enroll 23 adults who wi…

Researchers are testing whether adding entacapone to bevacizumab is safe and can slow tumor growth in adults with glioblastoma that has returned after standard treatment. The trial enrolls about 96 participants who have not previously received bevacizumab and for whom repeat surg…

Researchers are testing whether giving targeted therapy before and after surgery helps people with stage III non-small cell lung cancer that has specific rare gene changes. The study includes 190 adults whose tumors have alterations in genes like EGFR, ALK, ROS1, MET, RET, or KRA…

This study will test whether a nutrition supplement with different forms of certain nutrients works better than standard supplements for adults with cystic fibrosis. Sixty participants will take the supplement for six weeks, and researchers will measure nutrient levels in their b…

Researchers are testing a drug combination for people with advanced hepatocellular carcinoma, a type of liver cancer that cannot be removed by surgery. Participants receive lenvatinib plus tislelizumab, and some also receive gefitinib. The trial compares how long people live with…

Researchers are testing denecimig, an experimental antibody given as an injection under the skin, in adults newly diagnosed with acquired haemophilia A. This rare condition causes the immune system to attack a clotting protein, leading to sudden and sometimes severe bleeding. The…

Researchers are running a Phase 3 trial to see whether hydroxychloroquine or corticosteroids can reduce heart valve damage in children and young people with acute rheumatic fever. The trial enrolls about 600 participants aged 4 to 25 who are hospitalized with confirmed valve infl…

This phase 2 trial is testing whether an experimental drug called RO7568282 can slow the worsening of motor symptoms in people with early-stage Parkinson's disease. Participants, aged 40 to 85, must be on stable levodopa monotherapy. The study compares the drug against a placebo …

This Phase 2 trial tests whether combining the supplement alpha-lipoic acid with the drug mirabegron can improve how the body processes sugar in people with obesity. Sixty adults aged 18 to 65 with a BMI between 30 and 45 will take the combination or a placebo for 4 weeks. The st…

This trial tests whether a drug called carfilzomib, given directly to the liver through an implanted pump, is safe for people whose colon, adrenal, or bile duct cancer has spread to the liver and persists after prior pump therapy. Participants receive weekly infusions of the drug…

Researchers are testing whether adding zolbetuximab to standard chemotherapy is safe and helps control advanced stomach or gastroesophageal junction cancer in Indian patients. The trial enrolls 50 adults whose tumors carry the Claudin 18.2 protein but not HER2. Participants recei…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This early study tests an experimental drug called zeprumetostat in people with a rare type of leukemia (T-cell large granular lymphocyte leukemia) that has not responded to or has come back after other treatments. Ten participants take the drug twice daily for two 28-day cycles.…

This phase 2 trial tests a combination of a vaccine (TriAdeno) and an immune-boosting drug (N-803) in 52 men with early-stage, low- or medium-risk prostate cancer who are currently on active surveillance. The vaccine targets three proteins found in prostate cancer cells, while N-…

This early-phase trial tests a new therapy for people with advanced small cell lung cancer or similar neuroendocrine cancers that have not responded to prior treatment. The approach involves collecting a patient's own immune cells, modifying them in a lab to recognize a protein c…

Researchers are testing whether adding cryoablation, a procedure that freezes tumors, to two drugs can help people with advanced biliary tract cancer that worsened after first-line treatment. The drugs are QL1706, a dual immunotherapy, and lenvatinib, a targeted therapy. The tria…

Researchers are running a phase 1 trial of SHR-4595, an experimental injectable drug, in adults with advanced solid tumors that have not responded to standard treatments. The study checks how safe and tolerable the drug is, how the body processes it, and what dose might work best…

Researchers are testing a combination of three oral drugs, imlunestrant, abemaciclib, and selinexor, in people with low grade serous ovarian cancer or endometrioid endometrial cancer. The trial enrolls 60 participants in two separate groups, one for each cancer type. Everyone rec…

This phase II trial tests whether combining bevacizumab, a drug that limits blood vessel growth, with PRGN-2012, a vaccine-based therapy, can help adults with recurrent respiratory papillomatosis (RRP) avoid needing more surgeries. RRP causes wart-like growths in the airway that …

Researchers are testing whether adding sacituzumab tirumotecan and subcutaneous pembrolizumab to chemoradiotherapy helps people with muscle-invasive bladder cancer live longer without the cancer growing or returning. The trial enrolls about 400 people who have chosen bladder pres…

Researchers are testing a drug called CBX-12 in children and young adults with solid tumors that have returned or stopped responding to treatment, including rhabdomyosarcoma and Ewing sarcoma. CBX-12 pairs a tumor-seeking peptide with exatecan, a chemotherapy drug that blocks can…

Researchers are testing whether QL1203, a proposed biosimilar of the drug Vectibix (panitumumab), behaves similarly in the body to the original Vectibix when both are combined with chemotherapy (mFOLFOX6). The trial enrolls adults with RAS wild-type metastatic colorectal cancer t…

This study tests two new ways to treat talaromycosis, a serious fungal infection in people with HIV. It compares a single high dose of a newer antifungal drug (liposomal amphotericin B) against two weeks of the standard drug, and also checks if adding another medicine (flucytosin…

Researchers are testing an oral drug called safusidenib in adults newly diagnosed with IDH1-mutant grade 3 oligodendroglioma or astrocytoma, two types of brain tumor. Safusidenib is designed to cross into the brain and block the mutated IDH1 enzyme that drives these tumors. All 2…

This study tests a combination of four drugs (epalrestat, HAIC, donafenib, and tislelizumab) as a first treatment for people with advanced liver cancer that cannot be removed by surgery and who also have diabetes. The goal is to see if this approach can control the cancer for at …

Researchers compare dapagliflozin, a diabetes drug, with metformin, the standard insulin-sensitizing treatment, in women with polycystic ovary syndrome. The trial enrolls 70 women aged 18 to 40 who have PCOS and infertility. Over the study, the team measures changes in follicle-s…

Researchers are testing whether adding atrasentan to standard supportive care improves kidney structure and function in adults with IgA nephropathy, a condition where the immune system damages the kidneys. About 20 participants will take atrasentan 0.75 mg once daily for 52 weeks…

This phase 2 trial tests an oral drug called nemtabrutinib in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) whose cancer has stopped responding to other targeted therapies. Participants take nemtabrutinib once daily in 28-day cycles until the …

This phase 3 trial tests a drug called tralesinidase alfa in 14 children aged 1-5 with Sanfilippo syndrome type B, a rare genetic disease that causes severe brain damage. The drug is given directly into the brain fluid to replace a missing enzyme. The goal is to see if it can slo…

After an allogeneic stem cell transplant, patients often face weeks with dangerously low platelets and need frequent transfusions. This trial tests whether romiplostim, a drug that stimulates platelet production, helps platelets recover faster. Researchers randomly assign 87 adul…

This study tests a radioactive drug called 177Lu-DOTA-EB-TATE in 18 adults with a rare thyroid cancer (Hurthle cell) that has spread and not responded to standard radioactive iodine treatment. The drug is designed to seek out and attach to cancer cells. Participants will receive …

Researchers test whether a short course of targeted radiation followed by the immunotherapy drug adebrelimab and NALIRIFOX chemotherapy can shrink locally advanced pancreatic cancer enough to allow surgery. The trial enrolls 36 adults with previously untreated pancreatic ductal a…

Researchers are testing whether an educational and implementation tool helps hospitals follow best-practice guidelines for preventing second strokes caused by heart conditions. The trial enrolls about 2,400 patients who have had an ischemic stroke or a transient ischemic attack. …

Researchers are testing whether a liver-sparing form of chemoembolization, called partial TACE, can boost the anti-tumor effects of the drug lenvatinib in people with liver cancer that cannot be removed by surgery. The trial enrolls about 40 adults with hepatocellular carcinoma w…

Researchers are testing a radiopharmaceutical called 161Tb-PSMA-1 in adults with metastatic clear cell renal cell carcinoma that has worsened after at least two prior treatments, including immunotherapy and drugs that block blood vessel growth. The trial has two parts: a dose-esc…

This trial tests an experimental drug called SFL-0821 in adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic condition that causes progressive muscle weakness. Researchers give the drug by intravenous infusion, either once or multiple times, and compare it agains…

This trial is testing an experimental eye gel called BETA-TT8 for people with wet age-related macular degeneration (AMD), a condition that causes rapid vision loss. The gel is applied to the eye up to three times daily for 12 weeks, and standard injections remain available if nee…

Researchers are studying whether patients can safely leave the hospital within 48 hours after minimally invasive colorectal surgery. The trial follows 97 adults having elective laparoscopic or robotic surgery for benign or malignant disease. It checks how many meet predefined cli…

Researchers are testing whether combining BL-B01D1, an experimental antibody-drug conjugate, with glecirasib, a targeted KRAS G12C inhibitor, can shrink tumors in adults with locally advanced or metastatic non-small cell lung cancer that carries a KRAS G12C mutation. The phase 2 …

This trial tests whether mazdutide, an experimental weekly injection, can reduce fat buildup in the pancreas of adults with overweight or obesity. About 194 participants will receive either mazdutide or a placebo, alongside standard lifestyle advice, for 48 weeks. Researchers wil…

Researchers are testing whether adding an experimental drug called F182112 to isatuximab and lenalidomide is safe and can help people with newly diagnosed multiple myeloma who are eligible for a stem cell transplant. The trial enrolls about 10 adults aged 18 to 70. Participants r…

Researchers are testing a three-drug regimen called VAM for older or unfit adults with newly diagnosed acute myeloid leukemia (AML). The regimen combines liposomal mitoxantrone, azacitidine, and venetoclax. The trial aims to find the safest and most tolerable dose of liposomal mi…

Researchers are studying depemokimab, an injected biologic drug, in adults aged 18 to 75 who have allergic bronchopulmonary aspergillosis (ABPA) along with severe eosinophilic asthma. The study tracks how many asthma attacks need systemic steroids and whether participants' qualit…

This early-stage trial tests an oral capsule containing a genetically modified probiotic yeast designed to neutralize toxins produced by C. diff bacteria. The study first evaluates safety in healthy adults, then in people at risk for recurrent C. diff infection. Participants take…

This trial tests whether treating high blood pressure in pregnancy to a stricter target (below 140/90) is better than the usual approach (below 160/110) for women with gestational hypertension or preeclampsia without severe features. About 4,120 pregnant women will be randomly as…

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

This trial tests whether a daily routine of tummy time and careful positioning can help correct cranial asymmetry—a flattened head shape—in premature newborns. About 300 babies born before 37 weeks who are in the neonatal ICU or intermediate care unit will be split into two group…

Researchers are testing whether drug testing in patient-derived organoids can guide chemotherapy for low-grade non-muscle invasive bladder cancer. Adults with primary or recurrent low-grade bladder cancer receive one of four chemo drugs, epirubicin, mitomycin C, gemcitabine, or d…

Many people who have bariatric surgery do not lose as much weight as expected or regain it over time. This trial tests whether tirzepatide, a weekly injection that acts on two gut hormones, helps adults with obesity lose more weight after surgery. Participants receive either tirz…

This early-stage trial is testing an experimental drug called SNC116 in people with refractory systemic lupus erythematosus (SLE), a form of lupus that hasn't improved with standard treatments. The study aims to see if a single intravenous infusion of SNC116 is safe and tolerable…

This study provides continued access to alpelisib for people who are already benefiting from it in a previous Novartis trial. It focuses on tracking long-term safety, including any side effects, in participants with PIK3CA-related overgrowth spectrum or certain breast cancers. Pa…

Researchers are testing REGEND001, a therapy made from a patient's own airway basal stem cells, to see if it can improve lung function in people with chronic obstructive pulmonary disease (COPD) and emphysema. The trial enrolls adults aged 40 to 75 with moderate to severe COPD. P…

Researchers are testing whether a shared checklist used during lung cancer surgery helps surgeons achieve cleaner, more complete tumor removal. The trial enrolls adults with early-stage non-small cell lung cancer who are scheduled for surgery. Half the participating hospitals use…

Researchers are testing a chemotherapy combination built around albumin-bound paclitaxel (II) for people with pancreatic cancer. The study has three groups: one for advanced cancer that cannot be removed by surgery, one for cancer that may be removable and receives treatment befo…

Researchers are testing a new biological therapy called BI 4060107 in adults with advanced solid tumors that cannot be removed by surgery. The trial is for people who have tried all available treatments and have no other options. The main goal is to find the highest dose that peo…

This trial is for people with ER-positive, HER2-negative advanced breast cancer whose disease has started to grow in a few spots while on hormone therapy and a CDK4/6 inhibitor. It tests whether adding targeted radiation (SABR) to those spots allows patients to stay on their curr…

Researchers test whether Bacillus probiotics, given alongside standard four-drug antibiotics for H. pylori infection, reduce gut side effects and improve treatment tolerance. The trial enrolls 336 adults with H. pylori who receive either a single-strain probiotic, a multi-strain …

Researchers are testing whether combining an experimental dual immunotherapy drug called QL1706 with standard chemotherapy (docetaxel, oxaliplatin and S-1) before surgery can help patients with locally advanced gastric or gastroesophageal junction cancer. The study enrolls 34 adu…

Researchers at the University of Oklahoma are testing whether adding pentamidine, an antiparasitic drug, to standard modified FOLFIRINOX chemotherapy is safe and helps shrink tumors in people with advanced or metastatic pancreatic cancer. Up to 30 adults with confirmed locally ad…

Researchers are testing a new immunotherapy called Lm-LLO-TT in adults with advanced pancreatic ductal adenocarcinoma that has already been treated with chemotherapy. Lm-LLO-TT uses a weakened form of Listeria bacteria engineered to carry a tetanus toxoid antigen, aiming to spark…

Researchers are testing whether an oral drug called vepugratinib can clear low-grade, intermediate-risk bladder cancer that has not invaded muscle, or low-grade upper tract urothelial cancer. The trial enrolls adults whose tumors carry a specific change in the FGFR3 gene. Partici…

Researchers are studying giredestrant, an experimental daily pill, in people with estrogen receptor-positive, HER2-negative early breast cancer. The trial enrolls about 1,500 participants, including some who switch to giredestrant after other treatments. It tracks how many people…

This study compares four different sequences of biologic drugs (infliximab, filgotinib, ustekinumab, and vedolizumab) in 240 adults with moderate to severe ulcerative colitis. The goal is to see which order of treatments works best to achieve and maintain remission without steroi…

Researchers are comparing an experimental oral drug called VT3989 with standard chemotherapy drugs gemcitabine or vinorelbine in adults with advanced epithelioid pleural mesothelioma. All participants have already received platinum-based chemotherapy and immunotherapy, and their …

Researchers are testing an experimental oral drug called ONO-2808 in adults with the Parkinsonian subtype of multiple system atrophy (MSA-P), a rare and progressive brain disorder. The phase 3 trial enrolls about 486 people in the early stages of the disease, within five years of…

Researchers are testing whether adding CT-guided thermal ablation of liver or lung metastases to standard systemic therapy improves tumor response in people with nasopharyngeal carcinoma. The trial enrolls 138 adults whose primary tumor was cured but who later developed up to fiv…

This phase 2 trial tests whether adding a gene therapy called nadofaragene firadenovec to standard chemotherapy and immunotherapy can improve outcomes for people with muscle invasive bladder cancer before they have their bladder removed. The gene therapy is placed directly into t…

Researchers are testing whether adding two oral drugs, avutometinib and defactinib, to standard chemotherapy (mFOLFIRINOX) is safe and can slow or shrink pancreatic ductal adenocarcinoma. The trial has two parts: one for people whose cancer has spread, and one for people whose ca…

Researchers are testing whether adding an experimental drug called HLX22 to standard trastuzumab and chemotherapy helps people with locally advanced or metastatic HER2-positive breast cancer that has already been treated with a HER2 ADC. About 90 adults will receive either HLX22 …

Researchers are testing a new way to deliver antibiotics to the brain in people with moderate to severe bacterial meningitis who are not improving on standard intravenous treatment. The approach combines standard IV antibiotics with a continuous infusion of three antibiotics (van…

Researchers are running a first-in-human Phase 1 trial of JUR-003, an intravenous biologic, in adults with metastatic prostate cancer. The study has two parts: a dose-escalation phase to find the highest dose people can tolerate, and a dose-expansion phase to look at early anti-t…

Researchers are running a Phase I trial of HEC-921, an experimental drug given by intravenous infusion, in adults with advanced malignant solid tumors. The study first gives HEC-921 alone to find the highest dose people can tolerate, then tests it in combination with oxaliplatin,…

Researchers are testing whether infusions of bone marrow-derived mesenchymal stem cells, called MesenCell, are safe for adults with moderate or severe chronic graft-versus-host disease that has not responded to steroids and other standard treatments. The trial enrolls up to 20 pe…

This study tests a new immunotherapy designed to help the immune system recognize and attack cancer cells in people with high-risk Ewing sarcoma or desmoplastic small round cell tumor (DSRCT). The treatment targets a specific genetic change found only in these cancer cells, aimin…

Researchers are testing whether women aged 65 and older with early-stage, lymph node-positive, ER+/HER2- breast cancer can safely skip chemotherapy. Participants receive CDK4/6 inhibitors, with or without endocrine therapy, after surgery. The trial tracks how many women remain fr…

When children lose bone to injury, infection, or surgery, doctors can rebuild the limb in different ways. This French study compares two established techniques: the induced membrane method and the vascularized fibula flap, which moves a piece of the calf bone with its blood suppl…

Researchers are testing an experimental drug called MWN117 to see if it is safe and how the body handles it. The trial enrolls 48 healthy and obese Chinese adults who receive a single injection under the skin of either MWN117 or a placebo. Participants are split into groups that …

This study compares two FDA-approved drugs, momelotinib and ruxolitinib, in people with myelofibrosis who also have low blood cell counts. The main goal is to see which drug does a better job at shrinking the spleen and reducing the need for blood transfusions. About 268 particip…

Adults with a secundum atrial septal defect (a hole in the heart) who are scheduled for device closure receive either dapagliflozin or a placebo for six months. Researchers use advanced echocardiography to measure how well the right side of the heart recovers and reverses its enl…

Researchers are testing an experimental injectable drug called SHR-1179 in obese adults. The trial aims to see how safe and tolerable a single dose is, and how the body processes the drug. About 50 participants with a body mass index between 28 and 35 will receive either SHR-1179…

This Phase II trial tests whether an immune-boosting drug (N-803) alone or combined with a vaccine (ETBX-071) can lower PSA levels in men whose prostate cancer has returned after targeted radiation therapy. Participants receive up to eight cycles of treatment and are followed for…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

Researchers compare two oral antifungal medicines, itraconazole and posaconazole, in people with chronic pulmonary aspergillosis, a fungal infection that damages the lungs over time. The trial enrolls 220 adults who have not yet received antifungal treatment and assigns them to o…

Researchers are testing an experimental injectable drug called ALK-N001 in adults with advanced gastrointestinal tumors, including esophageal and colorectal cancers that have worsened after standard treatment. The phase II trial gives the drug intravenously every two weeks at one…

Researchers are testing whether measuring specific proteins in tumors can help match patients with advanced pancreatic or breast cancer to antibody-drug conjugates that are more likely to work for them. The trial enrolls 225 adults whose cancer has progressed after prior treatmen…

Researchers are testing whether adding the immunotherapy adebrelimab to HS-20093 (risvutatug rezetecan) works better than HS-20093 alone in adults with advanced or metastatic non-squamous non-small cell lung cancer that has already been treated and has no actionable gene changes.…

Researchers are studying whether adding local treatments such as ablation, radiotherapy, or transarterial therapy to the drug combination atezolizumab plus bevacizumab helps certain patients with unresectable hepatocellular carcinoma live longer. The study uses medical records an…

Choledochal cyst is a congenital bile duct problem that surgeons treat by removing the cyst and rebuilding the bile duct with a Roux-en-Y hepaticojejunostomy, often using a surgical robot. Surgeons usually leave an abdominal drainage tube in place afterward, but better robot prec…

This phase 2 trial is investigating whether an experimental drug called ARGX-121 can improve outcomes for adults with IgA nephropathy, a kidney disease that can lead to kidney failure. Participants will receive either ARGX-121 or a placebo, while continuing their usual care. The …

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

Researchers are testing whether a new combination of two antibodies, JS207 and JS007, works better than the standard first-line treatment of toripalimab plus bevacizumab for advanced liver cancer. The trial enrolls about 560 adults with liver cancer that cannot be removed by surg…

This phase II trial tests whether the experimental drug BL-B01D1, given with or without a PD-1 antibody, can improve tumor shrinkage in people with high-risk locally advanced nasopharyngeal carcinoma, a type of throat cancer. Participants also receive standard chemotherapy drugs …

Researchers are testing whether giving sacituzumab tirumotecan plus toripalimab before surgery helps people with locally advanced esophageal squamous cell carcinoma. Participants receive three cycles of the combination, then undergo standard surgery to remove the tumor. The main …

This trial is testing whether a combination of drugs—inavolisib plus fulvestrant, with or without palbociclib—is safe for people with a specific type of advanced breast cancer (HR+, HER2-negative) that has a PIK3CA mutation, and who also have type 2 diabetes. The main focus is on…

Researchers are testing whether combining enfortumab vedotin and pembrolizumab can shrink muscle-invasive bladder cancer enough to avoid removing the bladder or using radiation. The trial enrolls 25 adults with confirmed muscle-invasive urothelial carcinoma that has not spread. P…

Researchers are testing whether adding the experimental oral drug HS-10370 to platinum-based chemotherapy, with or without the immunotherapy adebrelimab, works better than tislelizumab plus chemotherapy. The trial enrolls about 448 adults with previously untreated, locally advanc…

Researchers are running a first-in-human study of MGC030, an antibody-drug conjugate, in people with advanced solid tumors that have come back or stopped responding to standard treatment. The trial includes participants with urothelial, colorectal, gastric, gastroesophageal, esop…

This study tests a new drug called zanzalitinib in people with a type of advanced prostate cancer that no longer responds to hormone therapy and has spread to soft tissues or organs. The goal is to see if the drug can slow or stop cancer growth. About 19 participants will receive…

Researchers are testing whether adding focused radiation to the few remaining cancer spots helps people with advanced EGFR-mutant non-small cell lung cancer live longer without their disease getting worse. Participants first receive a third-generation EGFR-targeted drug plus plat…

This study tests if a single high dose of an antifungal drug works better than the standard daily dose for treating moderate to severe histoplasmosis, a serious lung infection. It also compares a newer oral drug to the standard one, and checks if 6 months of treatment is as good …

Researchers at Assiut University Children Hospital are studying whether a specially prepared medical milk formula called Modulen IBD can bring Crohn's disease into remission and keep it there in children and teenagers. About 40 young patients with mild to moderate active Crohn's …

This phase III trial tests whether the oral drug nerandomilast can improve symptoms of idiopathic inflammatory myopathies, a group of rare autoimmune diseases that cause muscle weakness and inflammation. Adults with active myositis are randomly assigned to take nerandomilast or a…

Researchers are testing whether an experimental drug called telisotuzumab adizutecan works better than standard chemotherapy for people with non-squamous non-small cell lung cancer that has grown after earlier treatment. The trial enrolls about 660 participants whose tumors are E…

This study tests whether a pharmacist-led electronic consultation can improve lung health for people with HIV who smoke or use certain medications that raise pneumonia risk. Pharmacists will review records and suggest changes like smoking cessation aids, vaccines, or stopping unn…

Researchers at a Malaysian hospital reviewed ten years of records for 160 adults who received intrapleural fibrinolytic therapy, a mix of alteplase and DNase delivered through a chest tube, for complicated pleural infection. The study compares how well the treatment cleared fluid…

This trial tests an experimental drug called TUB-040 in adults with advanced non-small cell lung cancer that cannot be removed with surgery or has spread. TUB-040 is designed to attach to a protein on cancer cells and deliver a toxic payload directly to the tumor, potentially kil…

This study tests whether a special low-calorie, plant-based diet taken for 5 days each month can safely improve blood flow to the brain in middle-aged adults who carry the APOE4 gene, which raises Alzheimer's risk. Forty participants aged 45-65 will be randomly assigned to either…

Researchers at Assiut University are studying whether combining cataract surgery with a procedure called goniotomy safely lowers eye pressure and reduces the need for glaucoma medications. The trial enrolls 70 adults with cataract plus either primary open-angle or primary angle-c…

Researchers are tracking how long adults with moderate to severe Crohn's disease or ulcerative colitis keep taking guselkumab, a biologic drug, in routine care. The study follows about 400 people who start the treatment and records when they stop. It also checks whether early imp…

This observational study is looking at whether Ferretab comp., an oral iron and folic acid supplement, can improve anemia and heart-related symptoms in adults who also have coronary artery disease or heart failure. Participants take the supplement for 12 weeks as part of their us…

Researchers are studying the safety of selpercatinib, an oral drug, in people in India with advanced cancers that have changes in the RET gene. The trial includes adults with RET fusion-positive non-small cell lung cancer and adults and children aged 12 and older with RET-mutant …

This phase 3 trial compares adding doxorubicin and ifosfamide (AIM chemotherapy) before standard treatment with pembrolizumab, radiation therapy, and surgery versus standard treatment alone in patients with high-risk soft-tissue sarcomas that can be removed by surgery. Participan…

Researchers are testing a combination of paclitaxel polymeric micelles and ivonescimab in adults with small cell lung cancer that has returned or stopped responding after platinum-based chemotherapy and anti-PD-1/PD-L1 therapy. The phase 2 trial aims to see how many participants'…

Researchers are testing whether limiting all meals and snacks to a 9-hour window each day improves blood sugar control, insulin levels, and daily metabolic rhythms in adults with obesity and prediabetes. The trial enrolls 26 people aged 35 to 75 who usually eat over 13 hours a da…

Critically ill patients on breathing machines often get hospital-acquired lung infections. This trial tests whether adjusting antibiotic doses using drug level monitoring and software works better than standard dosing. About 610 adults in intensive care units will receive either …

Researchers are testing an experimental drug called BL-M08D1 alongside standard immunochemotherapy in adults with diffuse large B-cell lymphoma. The trial enrolls about 204 people aged 18 to 75 whose cancer has at least one measurable lesion. Participants receive BL-M08D1 plus a …

This phase 2 trial tests a three-part treatment for people with high-risk undifferentiated pleomorphic sarcoma (UPS), a rare cancer of soft tissue. Participants receive focused radiation (SBRT), the immunotherapy drug toripalimab, and a lower dose of the chemotherapy drug liposom…

Researchers are testing whether torvutatug samrotecan, alone or with bevacizumab, works better than standard care as maintenance therapy for people with platinum-sensitive relapsed ovarian, fallopian tube, or primary peritoneal cancer. The trial enrolls about 600 participants who…

Researchers are testing an experimental eye injection called GenSci148 in people with neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO). GenSci148 is a fusion protein designed to block four proteins involved in blo…

Researchers are testing whether adding stereotactic radiation to two drugs, envafolimab and endostar, helps people with stage IV non-small cell lung cancer. Participants have tumors without common EGFR, ALK, or ROS1 mutations and have not received prior systemic treatment. Everyo…

Researchers in Denmark are testing whether a structured weight loss program can slow the progression of atrial fibrillation in people who are overweight or obese. The trial enrolls 480 adults with symptomatic paroxysmal or early persistent atrial fibrillation and a body mass inde…

Researchers are testing whether adding pirtobrutinib to methotrexate and standard chemoimmunotherapy can help people with diffuse large B-cell lymphoma that has spread to the central nervous system. The trial enrolls about 24 people aged 14 to 80 whose lymphoma involves the brain…

Researchers are studying how stable the RayOne RAO800S intraocular lens is after cataract surgery. The lens replaces the eye's cloudy natural lens and has marks to help surgeons position it. Adults scheduled for cataract surgery in both eyes receive the lens as part of routine ca…

Researchers are testing whether a tablet form of the experimental cystic fibrosis drug VX-581 gets into the bloodstream as well as the liquid form. Sixteen healthy adults will take both forms in a randomized order, and researchers will measure drug levels in their blood over time…

This phase 3 trial tests whether adding an experimental drug called BG-C9074 to bevacizumab helps adults with epithelial ovarian, fallopian tube, or primary peritoneal cancer whose disease has not worsened after initial platinum-based chemotherapy plus bevacizumab. Participants r…

Researchers are testing whether adding rimegepant to standard chemoimmunotherapy before surgery helps shrink oral or oropharyngeal squamous cell carcinoma more effectively. The trial enrolls adults with primary or recurrent disease who are scheduled for surgery. Participants rece…

Researchers are testing whether adding the immunotherapy drug adebrelimab to standard chemotherapy before and after surgery can improve outcomes for people with locally advanced cervical cancer. About 35 participants will receive three cycles of adebrelimab plus paclitaxel and ci…

Researchers are testing whether a higher dose of proton beam therapy can normalise hormone levels better than standard radiotherapy in people with functioning pituitary tumours, including acromegaly and Cushing's disease. Participants receive about six weeks of either standard-do…

Researchers are testing an investigational drug called SKB571 in adults with advanced or metastatic pancreatic cancer. The trial aims to see how well the drug shrinks tumors and how safe it is. Participants receive SKB571 every three weeks, and doctors track their response using …

Researchers are testing an investigational oral drug called catequentinib hydrochloride (AL3818) in adults with advanced or metastatic endometrial cancer, low grade serous ovarian cancer, soft tissue sarcoma, or glioblastoma. The trial has two parts: a phase 1b part to find safe …

Researchers are testing a drug called 3D185 in people with advanced or metastatic cholangiocarcinoma, a type of bile duct cancer, whose tumors have changes in the FGFR2 gene. All participants have already received at least one other systemic cancer treatment that stopped working.…

Researchers are testing the drug cemiplimab, given alone or with other anti-cancer drugs, in people with locally advanced basal cell carcinoma that cannot be treated with surgery or radiation. The trial compares how well the combinations work against cemiplimab by itself and trac…

Researchers test whether a short, highly focused course of stereotactic body radiotherapy can safely treat prostate cancer that has come back in one small area after earlier radiation. The study enrolls 60 men under 80 whose cancer returned locally and who have not yet started ho…

Researchers are running a Phase 1 trial of HRS-1597, an experimental tablet for obesity and metabolic disorders. The study gives single doses to healthy volunteers and multiple doses to obese participants to check safety, tolerability, and how the drug moves through the body. It …

Researchers want to know whether leftover bile fluid can reveal genetic changes in tumors of people with advanced biliary tract cancer, such as bile duct or gallbladder cancer. Collecting tumor tissue for genetic testing can be difficult or risky in this cancer, so the study coll…

Researchers at M.D. Anderson Cancer Center are testing whether comprehensive genomic sequencing can identify specific subtypes of large B-cell lymphoma and provide information that may help guide treatment decisions. The trial enrolls about 60 adults with stage 3 or 4 diffuse lar…

Researchers are testing a new PET imaging agent called [68Ga]Ga-OncoACP3 that targets a protein called ACP3, which is found in prostate cancer cells. The study enrolls 50 men with suspected or confirmed high-risk prostate cancer, or suspected recurrence after treatment. Each part…

Sepsis is hard to spot early because its first symptoms look like many other conditions. Researchers at emergency departments in Taiwan are studying whether two blood markers, presepsin and immature granulocytes, can help doctors tell sepsis apart from other causes of inflammatio…

Researchers are building an artificial intelligence system that analyzes chest CT images and offers decision support to doctors reading those scans for lung cancer. They use deidentified CT exams from routine care to develop and lock the AI models. In the prospective stage, about…

Researchers are testing whether a smartphone app called Stethophone can help primary care doctors find moderate or severe aortic stenosis in adults aged 70 and older. The app turns a phone into a digital stethoscope and analyzes heart sounds for murmurs that may signal the condit…

Researchers are testing a new PET/CT imaging tracer called [68Ga]-LY4257529 that targets a protein called GRPR, which some cancers make in large amounts. The study includes up to 60 adults with breast cancer or other tumors known or suspected to express GRPR, such as prostate, ov…

Researchers are studying whether immune markers in a blood sample taken before pancreatic cancer surgery can predict a serious complication called postoperative pancreatic fistula, where digestive fluids leak from the surgical connection. Adults scheduled for curative-intent panc…

Researchers are testing whether sex work managers, called queen mothers, can hand out and collect HIV self-tests and self-collected STI test kits at places where female sex workers meet and work in Lusaka. The study compares this peer-supported approach with the current standard …

Radiation pneumonitis is a lung inflammation that can appear weeks after radiotherapy for lung cancer, and patients may not link their symptoms to the earlier treatment. Researchers developed a smartphone app called PneumoCheck for patients to use at home, hoping it helps detect …

Doctors usually send colorectal tissue to a lab and wait days for results. This pilot study tests a miniaturized device called MULTISCOPE that uses light-based imaging to tell healthy tissue from cancerous tissue in real time. Researchers will examine 30 tissue samples removed du…

Researchers are reviewing medical records from about 1,125 women in Italy with newly diagnosed advanced high-grade epithelial ovarian cancer. The study focuses on how hospitals test tumors for homologous recombination deficiency (HRD), a DNA repair flaw that can make PARP inhibit…

This trial tests a new AI device that helps surgeons see brain tumors on ultrasound images during surgery. The AI highlights tumor tissue in real time, which may help remove more of the tumor while protecting healthy brain. The study involves 100 adults scheduled for brain tumor …

This study checks if a simpler way to collect blood samples works as well as the standard method for the HepQuant DuO liver test. The test involves drinking a natural substance and taking blood samples 20 and 60 minutes later. Researchers will compare different blood collection t…

Doctors often wait days for genetic tests to classify acute myeloid leukaemia (AML) and guide treatment. This trial tests whether breath analysis can detect metabolic products from leukaemia and classify the disease faster. Participants give breath samples and extra blood tests d…

Researchers at Washington University School of Medicine are studying whether a fluorescent dye called indocyanine green can help visualize the edges of head and neck squamous cell carcinoma during surgery. The study plans to enroll 25 adults who are having surgery for confirmed o…

Researchers are testing whether early symptom relief from tegoprazan can help diagnose gastroesophageal reflux disease (GERD). Adults with frequent heartburn or acid regurgitation take tegoprazan or a placebo once daily for one week. By comparing symptom improvement between the g…

Researchers are running a large observational registry to see how a blood test called metagenomic sequencing is used in routine care for people with or at risk of serious infections, including those with weakened immune systems. The study enrolls participants at multiple hospital…

This study tests whether an artificial intelligence (AI) system can help doctors spot more precancerous polyps and colorectal cancers during colonoscopy compared to standard procedures. Over 3,300 adults scheduled for screening or surveillance will be randomly assigned to AI-assi…

Researchers at Assiut University are studying whether two ultrasound measures of fetal heart function and blood flow can predict poor outcomes in pregnancies complicated by diabetes or preeclampsia. The study enrolls 69 pregnant women, including those with gestational diabetes, p…

Researchers at Penn State University are testing three software innovations designed to improve bronchoscopy guidance during lung cancer evaluations. The study enrolls a small number of adults who are already scheduled for a clinical bronchoscopy to examine abnormal lung tissue o…

Researchers swab the noses of children scheduled for elective surgery under general anesthesia to check for respiratory viruses. They want to learn how many children carry viruses without showing symptoms and whether those children have more breathing problems during or after sur…

Researchers are building a web-based simulation platform to model how long blood cultures take from collection to result reporting in sepsis cases. The study involves microbiological laboratories that perform blood culture analysis. The goal is to understand how lab infrastructur…

Researchers are checking whether a Turkish translation of the Parkinson Neuropsychometric Dementia Assessment (PANDA) gives consistent and accurate results in people with Parkinson's disease. About 100 Turkish-speaking patients will complete the questionnaire, which tests memory,…

People with hormone receptor-positive, HER2-negative advanced breast cancer often start treatment with a CDK4/6 inhibitor plus an aromatase inhibitor. Over time, some tumors develop an ESR1 mutation that can make the aromatase inhibitor stop working. This study takes blood sample…

Researchers test a new endoscopic device called the loop brush fine needle aspiration (lbFNA) to sample pancreatic cysts in people scheduled for surgery. The pilot study enrolls 8 adults with cysts that require surgical removal. Doctors use the device to puncture, brush, and aspi…

Researchers at the University of British Columbia are collecting intestinal ultrasound images from adults, including healthy people and those with inflammatory bowel disease such as Crohn disease or ulcerative colitis. The goal is to build a computer program that can measure bowe…

Researchers are testing a new way to measure how much sweat the body produces during controlled heat exposure. About 20 healthy volunteers and up to 10 people with ROSAH syndrome, a rare genetic condition that can cause reduced sweating, will sit in a temperature-controlled sauna…

Researchers are testing whether an artificial intelligence model can spot breast cancer on chest CT scans that women already receive during routine health exams. The study includes a retrospective phase to validate the AI on existing images and a prospective phase where the AI re…

Researchers are testing three advanced diffusion MRI sequences to see which one best identifies men who can safely skip a prostate biopsy. The study includes men with suspicious prostate MRI results and those already scheduled for a routine MRI. By comparing these new scans again…

This trial tests whether Epidiolex, a prescription CBD medication, can delay or prevent the first seizure in infants with Sturge-Weber syndrome, a rare condition that often leads to seizures and developmental challenges. The study enrolls babies aged 1 to 18 months who have brain…

Researchers are testing whether Sinovac's Anflu flu vaccine produces a strong immune response in pregnant women compared with Sanofi's Vaxigrip. The trial enrolls 150 healthy pregnant women between 22 and 34 weeks of pregnancy. Each participant receives one dose of either vaccine…

This study will test a mobile app called HealthMPowerment designed to help Black adolescents and young adults in Alabama take PrEP, a daily pill that prevents HIV. Ten teens and their adult supporters will use the app for a few weeks, and researchers will check if it's easy and a…

Researchers are testing whether a diet high in stearic acid, a type of saturated fat found in cocoa butter, improves blood vessel function compared with a diet high in oleic acid, the main fat in olive and canola oils. The trial enrolls 40 overweight or obese adults aged 40 to 70…

Researchers are testing whether giving an anti-PD-1 immunotherapy drug together with anlotinib after surgery can prevent or delay the return of esophageal squamous cell carcinoma. The trial enrolls adults aged 18 to 75 who had chemotherapy plus immunotherapy before surgery, then …

This study tests a school-based weight management program using a WeChat digital platform to help children in Fangshan District, Beijing, avoid excessive weight gain. About 1,400 children in grades 2 and 3 will either receive the program (health classes, daily physical activity, …

Trastuzumab deruxtecan (T-DXd) treats metastatic breast cancer but can cause interstitial lung disease (ILD), a form of lung inflammation that sometimes forces patients to stop treatment. Researchers are testing whether giving dexamethasone before each T-DXd infusion lowers the c…

Researchers at the University of Washington are studying whether an online community of practice helps pharmacists learn to prescribe PrEP, a daily pill that prevents HIV. The study enrolls about 500 pharmacists and pharmacy staff across the United States whose pharmacies do not …

Researchers test a hybrid breast cancer education program for women aged 20 to 65 who visit an obstetrics and gynecology clinic. The program combines a face-to-face session using a breast model with four weeks of educational messages and reminders sent through a mobile app. The t…

Researchers are testing whether a single dose of the antiviral drug baloxavir marboxil can stop influenza from spreading among people who live with someone who has the flu. The trial enrolls households in China where one person has confirmed influenza and up to five other members…

Clesrovimab is an FDA-approved antibody shot for infants under 8 months entering their first RSV season when their mothers did not get an RSV vaccine in pregnancy. Researchers at Emory University are measuring antibody levels in the blood and noses of 24 healthy infants who recei…

This study tests whether the drug rituximab can safely clear Epstein-Barr virus (EBV) from the blood of people who have received a solid organ transplant. High levels of EBV can lead to a serious cancer called post-transplant lymphoproliferative disorder (PTLD). The trial will en…

Researchers are testing an AI chatbot that gives personalized, culturally tailored advice on nutrition, physical activity, and goal setting to adults at risk for type 2 diabetes. About 30 adults aged 18 to 55 will use the chatbot for 6 weeks. The study will check whether the chat…

Researchers are testing whether an artificial intelligence tool can sort children by their risk of nearsightedness and guide personalized prevention, such as more outdoor time and special glasses. The trial enrolls about 1,600 students in grades 1 through 3 from public primary sc…

Researchers are testing whether a quadrivalent HPV vaccine can be given at the same time as a tetanus-diphtheria booster in healthy children and adolescents aged 9 to 15 in Indonesia. The trial compares children who receive both vaccines together with those who receive the HPV va…

This study tests whether a program led by community health workers can improve lung health for 800 people in Bhaktapur, Nepal, who are at risk for chronic respiratory diseases. The program includes tobacco cessation counseling, mask use during high pollution, handwashing, and flu…

Researchers at Emory University are running a rapid randomized controlled trial to see if small changes to digital messages and website design can help more people start and stay on HIV prevention medication (PrEP) through telehealth. The study includes adults in the United State…

Researchers are testing an experimental drug called INCA33890 in people with stage II or III colorectal cancer who have finished surgery and chemotherapy but still have tiny amounts of tumor DNA in their blood. This leftover DNA, called circulating tumor DNA or ctDNA, can signal …

This trial tests whether a short educational session during a routine primary care visit can help young people aged 13 to 26 understand overdose risks, recognize an overdose, and respond with naloxone. Providers in the intervention group deliver the education and offer naloxone a…

This study will test if using two heat probes instead of one can better prevent cervical cancer in 300 women with HIV in Zimbabwe. The standard single-probe treatment often fails in these women. The goal is to see if the two-probe method is safe, acceptable, and more effective at…

Researchers are testing a new injectable drug called VH5356136 to see if it is safe and how the body processes it. The trial enrolls about 160 healthy adults without HIV, ages 18 to 55. Participants receive a single dose of the drug or a placebo, and researchers monitor side effe…

This trial tests whether an animated health coach on a smartphone can help people who have abnormal cervical cancer screening results get the follow-up care they need. Many people skip these appointments, which can lead to preventable cancer. The study will enroll 750 adults aged…

Researchers at Tufts University are testing whether an interactive, customizable digital comic can help Black and Latino children ages 8 to 12 develop healthier eating and physical activity habits. The comic lets children make choices that change the story and health messages the…

Researchers are testing an experimental injectable drug called VH4367310 in healthy adults aged 18 to 55. The drug is a long-acting form of cabotegravir, a medicine already used to prevent HIV. This phase 1 trial gives a single increasing dose to measure how the body processes th…

Researchers at Johns Hopkins University are testing whether a short animated video and brochure, sometimes followed by a phone call, can help people at higher risk of lung cancer get low-dose CT screening. The trial enrolls adults aged 50 to 80 with a significant smoking history …

HPV vaccines can prevent thousands of cancer cases each year, but many children do not get them. Researchers at the University of Florida test whether a tablet app called Protect Me 4 helps parents and doctors talk about the vaccine and decide to give it. The trial enrolls parent…

Researchers at Vietnam National Cancer Hospital are testing whether adding one structured cognitive behavioral therapy (CBT) session to standard brief counseling helps cancer patients remain smoke-free. The trial enrolls 498 adults who smoked at cancer diagnosis and have stayed c…

Doxorubicin is a common chemotherapy for breast cancer, but it can damage the heart. This trial compares two diabetes drugs, empagliflozin and metformin, to see if either can protect heart function in women receiving doxorubicin-based treatment. About 150 women with breast cancer…

Critically ill patients on breathing machines often develop dangerous gut bacteria that can lead to hospital-acquired infections. Researchers are testing a synbiotic medical food, a mix of probiotics and prebiotics, to see if it safely reduces these harmful bacteria. The trial en…

People treated with radiation for oropharyngeal cancer can later develop damage to cranial nerves, especially the nerve that controls the tongue. This trial tests four approaches to see if they are safe and practical: high-dose prednisone, the injectable drug fremanezumab, a home…

This trial tests whether a smartphone-based mindfulness program can help adolescents and young adults with sickle cell disease manage chronic pain and sleep problems. Participants are randomly assigned to either use the mindfulness app for about 8 weeks or receive usual care. The…

Researchers are testing whether a dietary supplement called Galactol improves overall well-being and reduces gastrointestinal symptoms in adults with celiac disease who have functional abdominal bloating. The study enrolls 50 people aged 18 to 70. Participants take either Galacto…

Researchers are testing whether a noninvasive device called Hypersound can reduce chronic neuropathic or radicular pain in adults. The system uses external antennas to deliver radiofrequency energy to peripheral nerves without implants or needles. About 71 participants receive te…

This study tests a medicated foam (AMZEEQ®) on a rare skin condition called CARP, which causes brown, scaly patches. About 35 people aged 9 and older will apply the foam to one side of their body and a plain moisturizer to the other for 5 weeks. The goal is to see if the foam is …

This pilot study explores whether a personalized telerehabilitation program can help adults who notice cognitive slips in daily life. Participants include older adults and adults with Ehlers-Danlos Syndrome who report subjective cognitive complaints. Over six weeks, they receive …

This early-stage trial tests whether a single dose of pembrolizumab (Keytruda), a drug used for cancer, can safely reduce long-term neurological symptoms like brain fog and dizziness in people with long COVID. Fifteen adults who had COVID-19 at least six months ago and still have…

This early-stage trial will test whether higher-than-standard doses of memantine, a drug already approved for Alzheimer's, are safe and tolerable in 25 adolescents and young adults with Down syndrome. The study also looks for early signs that the drug might improve memory and thi…

Children scheduled for angiography often feel anxious, which can affect their heart rate, blood pressure and cooperation during the procedure. This trial tests whether a short virtual reality guided breathing exercise, delivered through a headset showing calming scenery, can redu…

Researchers are testing a six-week, nurse-led program that helps Chinese prostate cancer survivors and their female partners talk about sex, rebuild intimacy, and cope together after treatment. About 72 couples join the study, with half receiving the program plus standard survivo…

This trial tests whether ischemic conditioning — brief cycles of blood-flow restriction using pressure cuffs on the arms — can improve motor function and cognitive performance in people with Parkinson's disease. Over 12 weeks, 34 participants will receive 24 sessions of the thera…

Researchers at Hospital Universitario Austral in Argentina are testing whether a structured three-session music therapy program called MUSPAL360 can be delivered to hospitalized adults with advanced cancer receiving palliative care. The program combines live music therapy with 36…

This pilot study will test whether active music therapy (with a therapist) or passive music therapy (just listening to music) can improve exercise ability and motivation in 28 people with Parkinson's disease. Participants will do sit-to-stand and walking tests while receiving mus…

People with Parkinson's disease often struggle with balance and anxiety, and the two can make each other worse, especially when they try to walk and think at the same time. High-intensity aerobic exercise may help both, but Parkinson's symptoms make it hard for many to reach that…

Researchers compare two monthly replacement silicone hydrogel multifocal toric contact lenses in people over 40 who already wear soft contacts. The study measures how easy the lenses are to handle, especially removal, and other performance factors. About 60 participants with asti…

Researchers are testing whether Qigong, a mind-body exercise, can improve spinal mobility and reduce pain in women with fibromyalgia. The trial randomly assigns 36 women aged 30 to 50 to one of two online Qigong programs: one focused on fluid, mobility-intensive movements, the ot…

Researchers at Tongji Hospital are testing a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in 26 people with Parkinson's disease. The study uses MRI scans to customize electrode placement so the stimulation reaches deep brai…

This study tests whether a structured laughter yoga program can reduce burnout, stress, and compassion fatigue in nurse managers. Eighty nurse managers will either join laughter yoga sessions twice a week for 8 weeks or continue as usual. Researchers will measure changes in stres…

Researchers are testing an experimental drug called olatorepatide in adults with moderate to severe hidradenitis suppurativa who also live with overweight or obesity. Hidradenitis suppurativa causes painful lumps and tunnels under the skin. The trial compares olatorepatide with a…

This study tests whether a supplement called FibroThol (containing 2-Aticyto Complex and D-ribose) can help reduce pain and other symptoms in people with fibromyalgia. About 200 adults aged 18 to 65 who have had fibromyalgia for at least a year and are already on standard medicat…

Researchers at MD Anderson Cancer Center are studying whether routine electronic symptom monitoring improves quality of life and care experience for patients with pancreatic adenocarcinoma receiving chemotherapy or radiation before surgery. About 200 adults with operable or local…

Researchers at Sveti Ivan Psychiatric Hospital are testing whether high-frequency repetitive transcranial magnetic stimulation (rTMS) with the H7 coil reduces gambling disorder symptoms. The trial enrolls 60 men aged 18 to 64 who are starting treatment at a gambling disorder day …

This trial tests whether a single, two-hour online class called Empowered Relief can help American Indian adults with cancer-related pain. Participants learn three pain relief skills, create a personal plan, and get access to a free audio app for daily practice. The study aims to…

Researchers are testing whether an AI chatbot on WeChat helps early-stage cancer patients quit smoking. The chatbot uses the Multi-Theory Model to offer personalized advice, emotional support, and habit tracking around the clock. The trial compares the chatbot with phone-based pr…

Researchers at the University of North Carolina are testing a support program for young adults aged 18 to 39 who are receiving cancer treatment. A trained navigator contacts each participant at least once a month for four months by phone, text, email, or video, based on what the …

Adults with sickle cell disease often face severe pain crises that require hospital treatment with intravenous morphine. This trial compares standard morphine treatment with combinations that add paracetamol, ketamine, or nefopam. Researchers want to see if these combinations eas…

Researchers are testing a five-session meaning-centered psychotherapy called CASA in Puerto Rican patients with Stage III or IV breast cancer and their caregivers. The trial compares CASA with usual care in about 114 people to see whether the therapy reduces psychological distres…

Researchers are testing whether mazdutide, a weekly injected drug, reduces the number of gout flares in adults who have both obesity and gout. The study enrolls 30 people aged 18 to 65 with a BMI of at least 30 and at least two gout flares in the past six months. Everyone receive…

Researchers at Dana-Farber Cancer Institute are testing Healing Gardens, a mobile game that delivers pain-focused cognitive behavioral therapy and cancer pain education. The study enrolls 46 adults with advanced solid tumors who have chronic pain related to cancer or its treatmen…

This study tests a spiritual health program called PATH for cancer patients struggling with feelings of disconnection, loss of meaning, or existential distress. Twenty adults with any stage of cancer will attend six workshops combining role-playing, psychology, and dignity therap…

This trial tests whether an artificial intelligence chatbot can help men with prostate cancer better understand radiation therapy. Participants will use a plain-language chatbot alongside standard education from their care team. Researchers will measure changes in patients' confi…

Researchers compare two approaches to care after ileostomy reversal surgery in children. One group receives the Enhanced Recovery After Surgery (ERAS) protocol, which includes early feeding, early catheter removal, early walking, and multimodal pain control. The other group recei…

Researchers are testing whether a carbohydrate-rich clear drink given two hours before bariatric surgery helps patients with metabolic syndrome recover normal gastrointestinal function faster. About 208 adults scheduled for gastric bypass or sleeve gastrectomy will be randomly as…

Researchers are testing whether adding whole-body electromyostimulation (WB-EMS) to a supervised exercise program improves body composition, heart health, fitness, and quality of life in overweight or obese postmenopausal women. Thirty women aged 48 to 60 will join a 16-week prog…

Researchers are studying whether a procedure called fluoroscopy-guided transdiscal splanchnic nerve neurolysis can safely reduce severe upper abdominal pain in adults with pancreatic, gastric, or hepatobiliary cancer. Participants first receive a diagnostic nerve block with local…

Researchers are testing whether time-restricted eating, where all food is eaten within a 10-hour window each day, can reduce fatigue and slow frailty in older adults living with prostate cancer or metastatic breast cancer. The trial enrolls 132 people aged 55 and older who typica…

Many people treated with aromatase inhibitors for early-stage breast cancer develop joint pain and stiffness that can make it hard to continue the therapy. This Phase II pilot study tests whether hydroxychloroquine, an anti-inflammatory drug often used for inflammatory joint cond…

Researchers are testing whether ultrasound-guided microwave ablation can safely treat breast fibroadenomas, which are non-cancerous lumps that can cause pain or change the shape of the breast. The procedure uses a thin needle to deliver heat that destroys the lump under local ane…

Researchers at Emory University are studying a modified Argentine tango program called Adaptango for adults with Parkinson's disease, mild cognitive impairment, or dementia, alongside younger adults. Over three months, participants take part in biweekly choreographic sessions tha…

Researchers are testing whether a digital nutrition app called STRONG, paired with remote dietitian counseling, is practical and helpful for adults with pancreatic ductal adenocarcinoma who are starting chemotherapy or radiation. About 80 participants join the study and are assig…

Researchers are testing an experimental drug called GMDTC in adults with solid tumors who have mild kidney problems caused by cisplatin chemotherapy. The trial aims to find out if GMDTC is safe, what side effects it causes, and how the body processes it. Participants receive cisp…

Researchers at the University of North Carolina at Chapel Hill are testing whether daily exposure to S-cone stimulating colored light can reduce pain severity and pain sensitivity in adults with fibromyalgia or chronic widespread pain and fatigue. Participants use programmed ligh…

This study looks at whether bringing in palliative care early during an unplanned hospital stay can reduce aggressive treatments at the end of life for people with advanced cancer. About 493 adults with metastatic digestive, gynecological, ENT, or sarcoma cancers will be randomly…

Some brain tumors, including meningiomas, hemangioblastomas, and certain metastases, have a rich blood supply that makes surgical removal difficult and risky. This study tests whether blocking the tumor's feeding blood vessels with a catheter procedure before surgery reduces blee…

Researchers at Indiana University are testing whether a food carbohydrate powder made from raw corn and potato starch can raise levels of GLP-1, a gut hormone that helps people feel full. The trial enrolls 62 adolescents aged 12 to 18 with obesity. For two months, participants dr…

Researchers are testing whether personalised nutritional care from a trained dietitian improves quality of life for people aged 65 and older with pancreatic ductal adenocarcinoma. About 250 participants will be randomly assigned to either six months of individualised nutrition su…

Researchers compare two methods for replacing a missing front upper tooth with an implant right after extraction. One method, the Socket-Shield technique, leaves a thin piece of the tooth root in place to help protect the jawbone and gums. The other method uses the standard appro…

Researchers test whether adding one structured cognitive behavioral therapy session to standard brief quit-smoking advice helps cancer patients stop smoking. The trial enrolls 446 adults with cancer in Vietnam who smoked at diagnosis and still smoke. Everyone gets brief counselin…

This trial tests whether a traditional Chinese music therapy, called Ziwu Liuzhu Five-Element Music Therapy, can reduce anxiety in people with pancreatic cancer who are undergoing chemotherapy. The study will enroll 320 patients with mild-to-moderate anxiety and randomly assign t…

Researchers compare two surgical methods for removing an inflamed appendix in obese patients: laparoscopic (keyhole) surgery and traditional open surgery. The trial enrolls 166 obese adults with acute appendicitis, randomly assigning each to one of the two procedures. The main go…

Researchers are testing a gel made from orange peel extract to see if it can reduce the severity of mouth sores caused by radiation therapy in people with head and neck cancer. Thirty adults receiving radiation will be split into two groups: one gets the orange peel gel, the othe…

This study tests whether a virtual reality program can improve vision in 120 children, teens, and young adults who have lost part of their visual field (hemianopsia) after a brain tumor. Participants will use a VR headset at home for 8 weeks to do visual exercises. The goal is to…

Researchers are testing whether an intravenous lidocaine infusion works as well as a thoracic paravertebral nerve block for helping women recover after breast cancer surgery. The trial enrolls 112 adults scheduled for mastectomy or breast-conserving surgery. Participants receive …

Many people with Parkinson's disease develop hand tremor that standard drugs cannot control. This Phase 3 trial tests whether botulinum toxin injections, guided by each patient's tremor pattern, can reduce that shaking. Participants receive either the toxin or a placebo injection…

This study looks at whether an 8-week aerobic exercise program can improve blood vessel function in women who have finished chemotherapy for non-metastatic breast cancer. Forty women will exercise three times a week for 30 minutes at a moderate pace. Researchers will measure arte…

This study tests whether regular breathing exercises can improve symptoms of Postural Tachycardia Syndrome (POTS), a condition that causes dizziness and rapid heartbeat when standing. Twelve adults with POTS will practice breathing exercises daily for four weeks while researchers…

Researchers compare two palliative radiation schedules for people with incurable head and neck cancer. The standard Split Course takes several weeks and often causes hard-to-tolerate side effects. The study tests whether a shorter Quad Shot regimen can shrink tumors and ease symp…

This study looks at whether children, teens, and young adults with newly diagnosed osteosarcoma can safely leave the hospital when their methotrexate levels are slightly higher than usual after standard chemotherapy. The goal is to shorten hospital stays without increasing side e…

Researchers are testing whether a monthly injection of berobenatide can reduce the severity of obstructive sleep apnea and lower body weight in adults who have overweight or obesity and use a PAP breathing machine. The trial enrolls about 258 adults with moderate to severe sleep …

Researchers are testing a portable knee-training robot in children aged 6 to 12 with spinal muscular atrophy. Each child trains one leg with a flexible, individually tuned stiffness setting and the other leg with a rigid setting for up to 8 weeks. The trial compares how much knee…

Researchers at Lund University are testing a new way to deliver deep brain stimulation using a cluster of very thin, flexible microelectrodes. The study includes up to 12 adults with Parkinson's disease or essential tremor who are already scheduled for standard deep brain stimula…

RESP-FIT tests whether a home-based breathing muscle training program, paired with a mobile app for symptom tracking and activity monitoring, can improve breathlessness, breathing strength, and physical activity in adults with COPD. Researchers are enrolling 288 adults aged 40 an…

Researchers are testing whether a single high dose of psilocybin, given alongside a structured talking therapy called PEARL, reduces depressive symptoms in adults with advanced cancer. The trial enrolls 46 people in Ontario with stage IV solid tumors, sarcoma, melanoma, endocrine…

Researchers are testing whether mandala coloring can improve quality of life for people receiving cancer care. The trial enrolls 76 hospitalized cancer patients and assigns them to either a coloring group or a routine-care group. For three weeks, the coloring group uses a mandala…

Researchers compare two approved soft contact lenses to see which provides better distance vision in low-light conditions. The study enrolls 150 adults aged 18 to 39 who already wear reusable spherical silicone hydrogel lenses. Participants wear each lens for two weeks in a rando…

Researchers test traditional Chinese medicine body acupuncture in nurses, midwives, and doctors at an acute care hospital who report moderate or higher stress. Participants receive eight sessions over four weeks, with treatment chosen by TCM pulse and symptom patterns. The study …

This trial tests whether adding a donor nerve graft during implant-based breast reconstruction helps women regain breast and nipple sensation after nipple-sparing mastectomy. Each participant has one breast randomly chosen to receive the graft, while the other breast serves as a …

Researchers at Istanbul University are testing whether a structured home exercise program paired with self-management education helps adults with Parkinson disease improve balance, walking, hand dexterity, and quality of life. The trial enrolls 55 people aged 45 to 80 who have ha…

Researchers are testing whether placing small bands in the lower esophagus can create a barrier against stomach acid and ease GERD symptoms. The trial enrolls people with symptomatic GERD who have not had previous reflux surgery. Participants undergo an endoscopic procedure to pl…

Researchers are testing a digital tool called Mindbot, a chatbot on the LINE messaging app that guides hospitalized cancer patients through a 10-minute mindfulness session with breathing exercises and virtual reality. The trial enrolls 66 adults with cancer who are staying in the…

Researchers at Al-Azhar University are testing whether orthodontic archwires coated with zirconium dioxide nanoparticles move crowded teeth faster than standard uncoated wires. The trial enrolls 20 teenagers, ages 13 to 19, who have moderate crowding of the upper front teeth and …

Researchers are testing whether a topical gel containing sirolimus can flatten raised epidermal nevi and even out their color. The study enrolls people aged 6 and older who have had stable, non-inflammatory epidermal nevi for at least three years. Participants apply the gel twice…

Researchers are testing whether a six-week program of breathing-muscle training combined with high-intensity interval exercise improves diaphragm thickness, lung function, and aerobic fitness in boys aged 10 to 12 with obesity. Fifty boys are randomly assigned to the combined tra…

Colorectal cancer patients who live with a stoma often face stigma, social anxiety, and loneliness. Researchers are testing a six-week mindfulness and self-compassion program adapted for these patients. The pilot trial enrolls 20 adults who have finished active treatment and spea…

Researchers are testing whether a web-based game that teaches sleep hygiene can improve sleep quality and reduce fatigue in people receiving chemotherapy. The trial enrolls 56 adults undergoing chemotherapy who do not have a diagnosed sleep disorder. Half receive the gamified Sle…

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

This study investigates how eating three high-fat meals in a row changes vitamin E levels in the blood. Researchers will compare people with normal blood fats to those with high blood fats (hyperlipidemia). The goal is to understand whether fats in the blood can trap vitamin E, p…

This study investigates clonal hematopoiesis, an age-related condition where blood stem cells acquire mutations, and how it triggers inflammation linked to heart disease. Researchers will compare immune cells from healthy people, those with high-risk mutations, and patients with …

Researchers at Assiut University are studying how to identify malnutrition in critically ill children aged 1 month to 5 years admitted to a pediatric intensive care unit. The team uses a four-part ABCD approach that combines body measurements, blood markers, physical signs, and d…

Researchers want to understand the different ways pain works in people with rheumatic diseases such as lupus, rheumatoid arthritis, and Sjogren's syndrome. The study enrolls up to 225 people aged 9 to 85 who have or may have a rheumatic disease, plus healthy volunteers matched by…

Researchers are testing whether people with non-small cell lung cancer can collect their own small blood samples at home using a finger-prick kit. Participants receive standard treatment with docetaxel, paclitaxel, alectinib, or lorlatinib, and the samples measure how much cancer…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

Researchers are observing adults newly diagnosed with acute leukemia during their hospital stay to learn which factors raise the risk of venous thromboembolism, a serious blood clot condition. The study follows about 250 patients from admission to discharge or death, recording cl…

Researchers at Assiut University are studying adults with blood cancers who receive an autologous hematopoietic stem cell transplant, a procedure that uses a patient's own stem cells. The study follows 123 participants to measure survival, progression-free survival, complications…

Researchers are testing whether whole grain sorghum improves immune and metabolic health in adults with excess weight, and whether phenolic compounds in the grain drive those effects. Thirty participants eat foods made from high-phenolic sumac sorghum, low-phenolic white sorghum,…

Researchers want to know whether weight loss from laparoscopic sleeve gastrectomy changes neck pain, posture, and neck function. The study follows about 25 adults scheduled for this weight-loss operation at one hospital. Participants complete neck questionnaires, strength and mot…

Researchers want to know whether biological markers in blood and fat tissue can flag a young child's risk of becoming overweight later. The study enrolls 400 children under age 4 who are already scheduled for surgery, collecting a small blood sample and two tiny fat samples durin…

This natural history study looks at how life events during childhood might affect eating behaviors and weight gain in adults. Researchers will observe 110 healthy volunteers aged 18 to 60, measuring food intake, physical activity, blood sugar, and body fat. Participants will also…

This study looks at how a short, home-based high-intensity workout affects steroid hormones in men with low-grade prostate cancer who are on active surveillance. About 49 men will do one supervised bodyweight HIIT session and provide saliva samples. The goal is to see if the exer…

Researchers are studying how switching to efanesoctocog alfa (ALTUVOCT), a long-acting factor VIII therapy given once a week, affects adults and children with severe or moderate hemophilia A in routine care. The study tracks factor use, treatment satisfaction, and quality of life…

This study follows 400 children aged 5 to 7 with obesity or normal weight until age 12. Researchers will track puberty signs, hormones, genes, diet, and chemical exposures to see what predicts early puberty. No treatments are given; the goal is to gather information.

This study will follow 100 adults with Crohn's disease, ulcerative colitis, or other IBD, plus their healthy relatives, for up to 3 years. Researchers will collect blood, stool, tissue samples, and imaging to track how immune cells and genetics change over time. The goal is to fi…

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

This study is building a new questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will talk to 275 adults with Crohn's disease or ulcerative colitis to understand their self-care habits, then test the questionnaire to…

Researchers at the National Institute of Mental Health are studying how everyday feelings, like stress or frustration, influence decision-making. They will follow 420 adults aged 18 to 55, including healthy volunteers and people with varying levels of depression, anxiety, or addi…

Researchers are studying blood samples from 150 adults with lower-risk myelodysplastic syndromes (MDS) who receive luspatercept, a drug that boosts red blood cell production. The goal is to find metabolites and other biomarkers linked to fatigue, a common side effect of the treat…

Researchers at the University of California, San Francisco are studying how well a calibrated touch device measures sensation in the larynx and throat. The study includes adults with larynx or throat disorders, including those whose condition followed radiation or other cancer tr…

Researchers at Suleyman Demirel University are surveying lawyers registered with the Isparta Bar Association to understand how physical activity, stress, burnout, and job satisfaction relate to musculoskeletal pain. About 102 lawyers with at least five years of experience answer …

Researchers in Korea are reviewing medical records from about 2,000 patients with triple-negative breast cancer who received pembrolizumab plus chemotherapy before surgery. The study measures how many patients had no detectable cancer left in their breast and lymph nodes at surge…

This study follows 125 pregnant women from 30 weeks of pregnancy through their baby's first year. Researchers want to learn how diet, food access, and other social factors affect mothers' health, breastfeeding success, and baby growth. Participants will complete remote visits and…

Researchers are observing 300 adults aged 60 and older with inflammatory bowel disease who are starting an advanced therapy chosen by their usual care team. The study tracks immune-aging markers such as CD4/CD8 ratio and IL-6, along with frailty and nutrition, over 52 weeks. The …

Researchers at the University of California, San Francisco are following 100 adolescents and young adults, ages 12 to 21, who are starting GLP-1 weight-loss drugs like Ozempic, Wegovy, or Mounjaro. Over one year, participants answer online surveys about their eating behaviors and…

This study will follow 3,000 French patients with severe or complicated obesity who are taking semaglutide (Wegovy) as part of an early access program. Researchers will track weight changes, treatment patterns, and well-being over time using questionnaires. The goal is to underst…

Researchers are studying whether navigational memory fades before other spatial memory in people with Parkinson's disease and related conditions. The pilot includes 80 participants: those with mild or advanced Parkinson's, those with parkinsonism, and healthy volunteers. Particip…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

This study follows 70 people with PRKN- or PINK1-linked Parkinson's disease, as well as those with typical Parkinson's and healthy volunteers, over 5 years. Researchers will track movement, thinking, and mood symptoms, and collect blood, urine, and optional spinal fluid or muscle…

This study will give 50 women a Fitbit Inspire 3 to wear before and after DIEP flap breast reconstruction surgery. Researchers will track steps, heart rate, and sleep, and compare that data with short questionnaires about recovery. The goal is to learn more about how patients rec…

This study compares two approaches to notify relatives of people diagnosed with familial hypercholesterolemia (FH), a genetic condition causing very high cholesterol. One method lets patients share information themselves; the other has the study team contact relatives directly. R…

This study is testing a new questionnaire (called the QLQ-OV39) to see how well it measures quality of life in people with ovarian cancer. About 50 adults with early or advanced ovarian cancer will fill out the questionnaire and give feedback. The goal is to make sure the questio…

This study will test whether cancer patients receiving chemotherapy and radiation therapy can use wearable health devices, like fitness trackers, to monitor their heart rate and activity levels. Twenty adults will wear the device during treatment and for four weeks after, uploadi…

This observational study will take small liver samples from 8 adults with hemophilia A or B who had gene therapy at least 6 months ago. Researchers want to see how the gene therapy affected liver cells, including how many cells still carry the therapy and whether there is any liv…

Researchers want to understand why most IVF embryo transfers fail to implant and what goes wrong in pregnancies complicated by preeclampsia. They will collect small tissue samples from the womb lining of up to 500 women aged 18 to 50 who are already scheduled for a diagnostic hys…

Multiple myeloma is a blood cancer in which abnormal plasma cells build up in bone marrow, and inflammation may shape how the disease behaves. Researchers at Assiut University plan to study 60 people newly diagnosed with myeloma before any anti-myeloma treatment begins. They will…

This observational study gathers information from routine care on how localized rectal cancer is treated across Austrian hospitals. It aims to document the variety of treatment approaches, including total neoadjuvant therapy and immunotherapy, and their outcomes. By analyzing thi…

This study follows 80 people with spinal muscular atrophy (SMA) in Japan who receive Zolgensma (onasemnogene abeparvovec) as an intrathecal injection. The goal is to track safety issues, such as liver problems or blood clotting abnormalities, and to measure changes in motor funct…

Researchers are testing whether blocking three inflammation pathways at once (TL1A, IL-23, and α4β7) calms inflamed intestinal tissue more effectively than blocking each pathway alone. The study enrolls 30 people: 10 with ulcerative colitis, 10 with Crohn's disease, and 10 withou…

This study will test if an AI chatbot can give helpful nutrition advice to pregnant women. About 100 women will either use the chatbot or get standard care. The goal is to see if the chatbot is easy to use and if it helps improve diet and knowledge about conditions like gestation…

This study will follow 200 children with acute lymphoblastic leukemia or lymphoma to learn more about the short- and long-term side effects of asparaginase drugs. Researchers will track how often serious toxicities occur during standard treatment and a newer therapy called SJALL2…

This study will measure how the body uses energy and burns fat in 10 people with extreme obesity (BMI of 60 or higher). Participants will spend 23 hours in a special metabolic chamber and drink a labeled water to track energy use over a week. The goal is to better understand meta…

Anti-VEGF injections treat conditions like diabetic macular edema, age-related macular degeneration, and retinal vein occlusion by adding fluid inside the eye, which can briefly raise eye pressure. This observational study at Assiut University follows 50 adults receiving these ro…

This study tests better ways to screen and treat cervical cancer in women living with HIV in Kenya, who face a much higher risk. Researchers will use HPV self-testing, care navigators, and a mobile app to help more women get diagnosed and treated. The goal is to find strategies t…

Researchers are examining health records from adults diagnosed with diffuse large B-cell lymphoma, a fast-growing blood cancer, across multiple UK hospitals. The study asks whether a patient's ethnicity, level of socioeconomic deprivation, and other health conditions influence ho…

Researchers want to know whether caffeine consumption is linked to irregular heartbeats and daily physical activity in adults with heart failure, reduced left ventricular ejection fraction, and an implantable cardioverter-defibrillator (ICD). About 170 participants fill out a one…

This study follows 250 people with cystinosis, a rare genetic disorder that causes a buildup of the amino acid cystine, leading to damage in the kidneys, eyes, and other organs. Researchers will track how the disease progresses over time, including kidney function, eye problems, …

Researchers at Assiut University Children Hospital are studying how often children who come to the emergency department have an abnormal heart rhythm. The study includes children aged 1 month to 18 years who arrive with symptoms such as palpitations, chest pain, fainting, or trou…

This study will give 28 women with obesity either a calorie-restricted DASH diet or a standard American diet for 4 weeks. Researchers will track weight changes and analyze stool samples to see how diet affects gut bacteria and related health markers. The goal is to understand how…

This study asks whether healthcare providers in cancer centers hold negative attitudes toward patients with mental disorders, and what factors influence those views. Researchers will survey about 1,000 oncology professionals using a stigma questionnaire and interview some of them…

This study will use advanced MRI scans to look at kidney transplants in 140 patients. The goal is to see if MRI can measure how well the kidney is working and tell the difference between stable function and problems like rejection. Researchers hope this could lead to a non-invasi…

Filoviruses such as Ebola and Marburg cause severe hemorrhagic fevers with high death rates, and doctors know little about rare types like Bundibugyo virus. This observational study follows patients in France with confirmed filovirus disease to record how the illness unfolds. Res…

Researchers at Sohag University Hospitals are reviewing the medical records of 30 people treated for papillary thyroid cancer, the most common type of thyroid cancer. The study examines how far tumors extended beyond the thyroid gland and which complications appeared soon after s…

This Mayo Clinic study will test whether a special ultrasound technique, called shear wave elastography, can measure how stiff brain tumors are compared to healthy brain tissue during surgery. Researchers will enroll 30 adults with newly diagnosed or recurrent brain tumors. The g…

This study will follow 85 adults receiving stem cell transplants to track a serious but often missed complication called TA-TMA. Researchers want to find out how common it is and how it affects survival. Participants will provide blood samples and have standard follow-up care.

This study tests whether a video app that explains 'Undetectable = Untransmittable' (U=U) can help people with HIV stay on treatment and keep the virus under control. About 880 people from clinics in South Africa will use the app during counseling. The goal is to see if better un…

This study collects tumor tissue and blood samples from 120 cancer patients who are receiving or will receive immunotherapy. The samples will be stored in a biobank for future research to better understand how these treatments work. No direct treatment is given; the goal is to ga…

After thyroid surgery for differentiated thyroid cancer, patients often need to take thyroid hormone at doses that keep TSH in a specific target range. Researchers at West China Hospital are testing whether adding a short educational video to standard instructions helps patients …

Researchers at Shanghai Mental Health Center are following 500 people with obsessive-compulsive disorder to see how symptoms, daily functioning, and treatment responses change over time. The study includes adults aged 18 to 60, including some who have never received OCD treatment…

This study aims to find the best way to dose the antibiotic ceftazidime for patients in intensive care with serious infections. Many ICU patients don't get enough of the drug because their bodies process it differently. The researchers will test a personalized dosing plan to keep…

Researchers are reviewing medical records of 100 people with esophageal squamous cell carcinoma who received immunotherapy plus chemotherapy before surgery to remove the cancer. The study examines when and where cancer returns and which patient traits, treatment details, scan res…

This study looks at how the brains of women with anorexia nervosa respond to fatty food smells and images. Researchers will use brain scans to compare their reactions to those of healthy women. The goal is to understand why fatty foods cause aversion, which could help improve fut…

Researchers at the University of Texas at Dallas are studying how physical activity, sedentary behavior and self-control relate to loss of control eating in children. The study follows 200 children aged 10 to 12 for three years, using brain scans, activity monitors, and real-time…

This study explores whether artificial intelligence can help perform high-field whole-body MRI scans faster while keeping image quality high. Researchers will compare standard MRI sequences with AI-accelerated versions in 600 adults undergoing screening for prostate, lung, or vas…

Doctors use anti-VEGF injections to treat retinal diseases such as age-related macular degeneration and diabetic macular edema, and patients often need these shots for years. During each injection, a small tool holds the eyelids open, stretching the upper lid. Researchers want to…

Researchers are studying where the bacteria that infect skin sores come from in people with scabies or atopic dermatitis. They will compare bacteria grown from infected skin lesions with bacteria from nasal swabs to see if the same species appear in both places. A group of health…

Researchers at Anhui Medical University are studying bacteria found inside prostate tumors and how they relate to the immune system. The study uses leftover tissue samples and archived slides from about 100 men with prostate cancer or benign prostate disease. Scientists will sequ…

This project at King's College London asks how hospital outpatient departments can work better for people with neurofibromatosis who also have sensory challenges. About 30 patients, carers, and staff from Guy's and St Thomas' NHS Foundation Trust take part in interviews, observat…

Researchers at Anhui Medical University are studying how prostate cancer invades nerves, a feature linked to aggressive tumors and recurrence after surgery. They plan to collect tissue and clinical data from about 120 prostate cancer patients and compare nerve-invaded areas, ordi…

Researchers are studying how the cystic fibrosis drugs elexacaftor, tezacaftor and ivacaftor move through the body. The trial enrolls people aged 6 and older with cystic fibrosis who carry at least one F508del mutation and already take this drug combination. Participants keep the…

Researchers at Assiut University are studying whether metabolic syndrome, a cluster of conditions like high blood pressure and high blood sugar, relates to the clinical course of chronic Philadelphia-negative myeloproliferative neoplasms. These are rare blood cancers where the bo…

Researchers are following about 1,200 children in Zhejiang Province, China, from birth through age 7 to understand how the immune system develops and why some children get more respiratory infections or asthma. The study includes healthy children, children with a history of serio…

Researchers at Emory University are running a study to see whether influenza A or B spreads from adults who caught the flu in the community to healthy adults under controlled hospital conditions. Instead of using a lab-made flu strain, the study uses naturally infected donors as …

Researchers at the University of Bari Aldo Moro are testing whether augmented reality can help dentists perform oral surgery and orthodontic work more accurately. The study includes 10 healthy adults over 18 who need tooth extractions, dental implants, or braces. Before treatment…

Researchers at Assiut University are studying whether ionized calcium levels, measured from a routine blood sample when a patient enters the ICU, can signal how severe sepsis or septic shock is. The study follows 160 adults admitted to intensive care within 24 hours of presentati…

Some people who have keyhole lung cancer surgery develop lasting breathlessness and struggle with gentle exercise, even if their breathing was fine before. Researchers suspect the right side of the heart, which pumps blood to the lungs, may be weakened by the extra pressure it fa…

Researchers are studying how the HIV combination pill Descovy, which contains tenofovir alafenamide and emtricitabine, moves through the bodies of people with HIV who also have advanced chronic kidney disease. About 50 adults with stage 3b or stage 4 kidney disease will take part…

Researchers at the University of Liverpool are exploring how different menu labels affect food choices and feelings in adults with eating disorders, common mental health conditions like anxiety or depression, and no mental health diagnosis. Participants order a meal from a simula…

Laparoscopic fundoplication relieves reflux for most GERD patients, but 10 to 30 percent still have symptoms or side effects afterward. Researchers at Minia University Hospitals follow 470 adults scheduled for this keyhole surgery, measuring ten factors before the operation such …

Hospitals lack agreed rules for when a person with cancer should go to the intensive care unit (ICU) and when they are well enough to leave. This project brings together 30 to 40 cancer and critical care experts from around the world to vote on draft statements about ICU care. Th…

Researchers at a French sleep center are studying adults with obesity who are referred for a sleep study because of suspected obstructive sleep apnea. The team measures how much carbon dioxide builds up in the blood overnight using a skin sensor, then compares that cumulative exp…

Researchers are observing patients in China who have both a tumor in the sellar region of the brain and an unruptured intracranial aneurysm. The study compares three approaches: removing the tumor before treating the aneurysm, treating the aneurysm before removing the tumor, or r…

Researchers at Vanderbilt University Medical Center want to understand how immune cells use glucose, the body's main sugar, during critical illness. They give 25 adult ICU patients an intravenous infusion of a non-radioactive carbon-13 glucose tracer over a few hours. Then they c…

Researchers are measuring how often five animal-borne infections appear among inmates at the French Guiana Correctional Facility. The study follows newly arrived adults for up to 12 months, testing for Q fever, leptospirosis, Chagas disease, histoplasmosis, and toxoplasmosis. The…