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Did vitamins prevent cancer? 33,000 people tracked for decades

NCT ID NCT00342654

First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 38 times

Summary

This study follows up on a large trial from the 1980s where over 33,000 people in Linxian, China, took vitamin and mineral supplements to see if they could prevent esophageal and stomach cancer. Researchers are now tracking cancer cases and deaths in the years after the supplements stopped, and collecting blood samples to study genetic and environmental factors. The goal is to understand if the earlier benefits, like reduced stomach cancer, lasted over time.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Cancer Institute and Hospital, Chinese Academy of Medical Sciences

    Beijing, China

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

vitamins and minerals (beta-carotene, vitamin E, selenium, and multivitamins/minerals)

What this could lead to

If successful, this study could clarify whether taking certain vitamins and minerals can reduce the risk of esophageal and stomach cancer over the long term.

What could go wrong

This is a follow-up observational study, not a new treatment trial. The original intervention ended in 1991, so any benefits may have faded, and results may not apply to other populations.

Conditions

The condition(s) this trial relates to.

Esophageal Neoplasms gastric cancer gastric neoplasm neoplasm esophageal cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.