Breast carcinoma

This early-phase study tests a new drug called HLD-0117 in about 33 women with a type of advanced breast cancer (ER-positive) that has spread and stopped responding to standard therapies. The main goals are to check the drug's safety and find the right dose, while also seeing if …

This study compares two treatments for people with high-stage, estrogen-positive, HER2-negative breast cancer that has a low genetic risk of returning. One group gets standard hormone therapy plus a targeted pill (ribociclib), while the other gets chemotherapy first, then the sam…

This pilot study tests a device that uses short, high-frequency electrical pulses to shrink or destroy soft tissue tumors in people with metastatic breast cancer. The trial will enroll 20 adults with tumors near the skin that are at least 1 cm but no larger than 5 cm. The main go…

This study tests two experimental drugs, BNT323 and BNT327, together in people with advanced breast cancer that has spread or cannot be removed. The goal is to see if the combination can shrink tumors and control the disease. About 380 adults with various types of breast cancer (…

This study tests an experimental oral drug called zongertinib, which blocks HER2, a protein that fuels cancer growth. It is given alone or with other cancer drugs to adults with advanced HER2+ breast, stomach, or colorectal cancer that has spread and not responded to prior treatm…

This phase 2 trial tests whether specially selected immune cells taken from a patient's own tumor, grown in large numbers in the lab, and given back along with the drug pembrolizumab (Keytruda) can shrink tumors in people with metastatic colorectal, pancreatic, ovarian, breast, o…

This phase 2 trial tests whether adding cediranib or ceralasertib to olaparib can overcome resistance in BRCA-mutated advanced breast cancer. About 60 participants with HER2-negative, BRCA-positive tumors that have progressed on prior therapy will receive one of the two drug comb…

This early-phase trial is testing a new drug called BGB-21447, which blocks a protein that helps cancer cells survive. It is given together with standard hormone therapy (fulvestrant) and sometimes another targeted drug (BGB-43395). The study involves 120 adults with HR+/HER2- me…

This early-phase trial tests whether freezing a tumor (cryoablation) can boost the immune response to the drug pembrolizumab in people with metastatic or locally advanced triple negative breast cancer. About 30 participants will be randomly assigned to receive either the combinat…

This early-phase study tests a new drug called BGB-43395 in people with advanced HR+/HER2- breast cancer and other solid tumors. The drug blocks a protein (CDK4) that helps cancer cells grow. Researchers want to find the safest and most effective dose, either alone or combined wi…

This early-stage study tests a two-part system to find and treat metastatic cancer. First, a radioactive tracer is used to spot tumors on a PET scan. Then, a similar radioactive drug is given to deliver radiation directly to the cancer cells. The goal is to see if this approach i…

This study is testing many different drug combinations in people with metastatic breast cancer that has spread or cannot be removed by surgery. Researchers are looking at which combinations work best for different cancer types, such as triple-negative or hormone receptor-positive…

This Phase 1 trial is testing ZOLADEX (goserelin), a hormone-blocking implant, in 88 premenopausal women with HR+/HER2- advanced breast cancer. The goal is to see if it can temporarily shut down ovarian function, which may help control the cancer. Participants receive two injecti…

This early-stage study tests a new drug called BBO-10203 in people with advanced solid tumors (breast, lung, or colorectal cancer) that have not responded to standard treatments. The drug is designed to block two cancer-driving proteins (PI3K and RAS). Researchers will check safe…

Researchers are testing whether a single, concentrated dose of radiation to the tumor site can replace the usual weeks of daily radiation after breast-conserving surgery. The trial enrolls 250 women with early-stage, low-risk breast cancer that has not spread to lymph nodes. Doct…

This early-stage study tests a new drug called LOXO-783 in people with advanced breast cancer or other solid tumors that have a specific change in the PIK3CA gene. The main goals are to find the safest dose and check for side effects. About 193 participants will take the drug alo…

This study looks at how well the drug inavolisib works for people with a certain type of advanced breast cancer that has a PIK3CA gene change and has stopped responding to hormone therapy. About 500 participants in China will receive inavolisib as part of their regular care. Rese…

This phase 2 trial is testing whether adding a CDK4/6 inhibitor (palbociclib, abemaciclib, or ribociclib) to elacestrant works better than elacestrant alone for people with advanced ER+/HER2- breast cancer that has already been treated with a CDK4/6 inhibitor. The study will enro…

This phase II trial is testing whether giving a shorter, stronger course of radiation before breast surgery is safer and works better than giving it after surgery for people with non-metastatic breast cancer. The study will enroll 120 participants with different breast cancer typ…

This study tests whether giving a different antibody-drug conjugate (ADC) to people with advanced breast cancer who have already tried an ADC can still shrink tumors or slow the disease. About 160 participants will receive one of several ADCs or a targeted pill. The goal is to se…

This study tests whether adding tocilizumab, an anti-inflammatory drug, to standard chemotherapy improves outcomes for people with metastatic triple-negative or ER-low breast cancer. Researchers will compare the combination to chemotherapy alone in 168 Black and non-Black patient…

This study compares two drug combinations for people with a type of advanced breast cancer (HR+/HER2-) that has a specific genetic change (PIK3CA mutation) and has worsened after prior treatment. About 540 adults will receive either the experimental drug RLY-2608 plus fulvestrant…

This study tests a drug called trastuzumab deruxtecan (T-DXd) in 40 adults with advanced breast cancer that has no HER2 protein (HER2-0). Participants get the drug every 3 weeks. The goal is to see if it shrinks tumors and which patients benefit most.

This phase 3 trial is testing whether 6 months of HER2-targeted therapy (trastuzumab and pertuzumab) works as well as the standard 12 months for people with early-stage HER2+ breast cancer who had a complete response to initial chemotherapy. About 1,500 participants will be rando…

This early-phase study tests a new drug called DSB2455 in adults with advanced cancers (breast, ovarian, prostate, pancreatic, or brain metastases) that have a specific DNA repair problem. The main goals are to check safety and see if the drug shrinks tumors. About 180 participan…

This study tests whether a new treatment called Bria-IMT, given with an immunotherapy drug, helps people with advanced metastatic breast cancer live longer compared to standard chemotherapy. About 404 adults whose cancer has not responded to other treatments will participate. The…

This study compares a combination of two drugs (elacestrant and capecitabine) to capecitabine alone in people with advanced estrogen receptor-positive breast cancer that no longer responds to CDK 4/6 inhibitors. About 297 participants will be randomly assigned to one of the two t…

This phase 2 trial is testing two antibody-drug conjugates—trastuzumab deruxtecan (Enhertu) and datopotamab deruxtecan (Dato-DXd)—in people with HER2-negative metastatic breast cancer whose disease has worsened after prior antibody-drug conjugate therapy. Participants will receiv…

This phase 2 trial tests whether a patient's own white blood cells, genetically modified in a lab to recognize and attack their specific tumor mutations, can shrink metastatic cancers. Participants include people with several advanced solid tumors or multiple myeloma who have exh…

This study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab. The goal is to see if the combination is safe and helps the immune system attack advanced solid tumors. About 132 people with various advanc…

This study follows over 1,100 adults with HER2-low breast cancer that cannot be removed by surgery or has spread. Researchers will compare how long patients stay on trastuzumab deruxtecan (a targeted drug) versus standard chemotherapy before needing a new treatment. The goal is t…

This study compares a combination of two chemotherapy pills (capecitabine and cyclophosphamide) against standard maintenance treatments for women with advanced breast cancer whose disease is under control after initial therapy. The goal is to see which approach better delays canc…

This phase 3 trial is testing a new drug called palazestrant (OP-1250) combined with ribociclib against the standard letrozole plus ribociclib for people with ER+, HER2- advanced breast cancer who haven't had prior treatment. About 1,000 participants will be randomly assigned to …

This study looks at women with breast cancer that has spread to lymph nodes under the arm, found before surgery. Normally, doctors remove many lymph nodes, which can cause arm swelling and pain. The trial tests if removing only the first few affected nodes is just as effective fo…

This phase III trial tests whether proton craniospinal irradiation (pCSI) can improve survival compared to standard involved-field radiation therapy (IFRT) for patients with breast or non-small cell lung cancer that has spread to the lining of the brain and spinal cord (leptomeni…

This phase 2 trial is testing a type of radiation called craniospinal irradiation that avoids the hippocampus, a brain area key for memory. It is for people with breast or lung cancer that has spread to the fluid and lining around the brain and spinal cord. The goal is to see if …

This early-phase study is testing a new oral drug called BG-75202, alone or with other medications, in people with advanced breast cancer or other solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and …

This study tests a new drug called GTAEXS617 in people with advanced solid tumors (like lung, pancreatic, or ovarian cancer) that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. About 230 p…

This Phase 2 trial is testing whether the drug sacituzumab govitecan (Trodelvy) can shrink tumors in people with a specific type of advanced breast cancer (HR+/HER2 low or ultra low) who have already received another targeted drug called T-DXd. The study will enroll 75 participan…

This phase 2 trial tests whether giving the chemotherapy drug capecitabine in a flexible, response-based way (adaptive therapy) can better control metastatic ER-positive breast cancer. About 35 adults with advanced, hormone-resistant disease will receive doses that are adjusted b…

This phase II trial is testing whether an anti-viral drug called valganciclovir (Valcyte) can help treat breast cancer that has spread to the brain. The study includes 28 adults with progressive brain metastases who also have evidence of a common virus called CMV. Participants ta…

This early-stage trial tests a new drug called MEN2312, alone or with another drug (elacestrant), in 240 adults with advanced breast cancer that has specific genetic changes. The main goals are to find a safe dose and check for side effects. It is the first time MEN2312 is being …

This early-phase trial is testing a modified measles virus (MV-s-NAP) that is injected directly into tumors in people with metastatic breast cancer. The virus is designed to kill cancer cells and also carry an extra protein to boost the immune response. Researchers are monitoring…

This early-phase study tests the safety and best dose of two drugs, ZEN003694 and abemaciclib, given together. It is for people with advanced breast cancer, NUT carcinoma, or other solid tumors that have spread or cannot be removed by surgery. The goal is to see if the combinatio…

This study tests a drug called trastuzumab deruxtecan (T-DXd) against the usual treatment (a CDK4/6 inhibitor plus hormone therapy) for people with a certain type of advanced breast cancer. The cancer must be hormone receptor-positive, HER2-low or ultralow, and have a specific ge…

This phase II trial is testing whether adding a new oral drug called culmerciclib to standard anti-HER2 therapy and hormone therapy can help maintain control of advanced breast cancer that is both hormone receptor-positive and HER2-positive. The study enrolls women with metastati…

This trial tests whether using only hormone-blocking drugs can control breast cancer in women aged 70 and older who have a low-risk, hormone-sensitive tumor. Participants receive standard endocrine therapy instead of surgery or radiation. The goal is to see if this gentler approa…

This trial tests whether a silicone film called Mepitel Film can prevent radiation dermatitis — painful skin irritation — in breast cancer patients undergoing radiation therapy in Singapore's hot and humid weather. About 60 adults who have had breast cancer surgery and are schedu…

This early-phase study tests a new drug called M5A-IL2 immunocytokine together with precise radiation (SBRT) in people with advanced colorectal or breast cancer that has spread. The drug helps the immune system recognize and attack cancer cells. The goal is to find the safest dos…

This early-stage study is testing a new oral drug, PF-08032562, in people with advanced breast or colorectal cancer that has spread. The drug is given alone or with other cancer treatments. The main goals are to check safety, find the right dose, and see if it shrinks tumors. Abo…

This study investigates whether patients with HER2-positive metastatic breast cancer who have had their disease controlled for at least two years on anti-HER2 therapy can safely stop that treatment. Participants must also have no detectable cancer DNA in their blood (ctDNA-negati…

This early-phase trial tests a wearable device that creates electric fields (tumor treating fields) combined with either cabozantinib or nab-paclitaxel and atezolizumab in 43 people with advanced solid tumors in the abdomen or chest. The goal is to find the safest dose and see if…

This clinical trial is testing a combination of three drugs—entinostat, pyrotinib, and endocrine therapy—in people with advanced triple-positive breast cancer (cancer that is both hormone receptor-positive and HER2-positive) whose disease has worsened after prior treatment with t…

This study tests whether a single, high dose of radiation given before repeat breast-conserving surgery is safe and effective for women whose breast cancer has returned after previous treatment. The trial will enroll 25 women aged 50 or older with small, low-risk tumors. The goal…

This study tests whether adding tivozanib (a drug that targets blood vessel growth) to atezolizumab (an immunotherapy) can help the immune system attack cancers that normally resist immunotherapy. The trial includes people with several cancer types like bile duct, pancreatic, pro…

This early-phase trial tests the safety and best dose of a new drug combination—pidnarulex plus trastuzumab deruxtecan—in people with advanced breast cancer and other solid tumors that have the HER2 protein. The study enrolls 36 adults whose cancer has spread or cannot be surgica…

This early-stage trial is testing an experimental drug called BMS-986500 in people with advanced solid tumors or breast cancer that has not responded to prior treatments. The study will first test the drug alone, then in combination with other cancer drugs (palbociclib and fulves…

This study tests whether giving a precise, high-dose radiation treatment called SBRT to one growing tumor can help people with metastatic breast cancer keep their disease under control. Participants continue their usual drug therapy while receiving SBRT to a single site where can…

This early-phase trial is testing a new way to give the cancer drug T-DXd (Enhertu) — as a shot under the skin instead of an IV drip. The study will enroll 76 adults with metastatic solid tumors to find the safest dose and see how well the body handles it. Researchers will also c…

This study tests if a combination of three drugs (lenvatinib, pembrolizumab, and fulvestrant) is safe and works for people with ER-positive, HER2-negative breast cancer that has spread. About 54 adults whose cancer has not responded to other treatments will take part. The goal is…

This study tests a high dose of the chemotherapy drug methotrexate given through a vein in people with breast cancer that has spread to the lining of the brain. The goal is to see if it helps them live longer. The trial includes adults with triple-negative, HER2-positive, or horm…

This study compares two drugs, leuprolide and goserelin, to see how well they lower estrogen levels in premenopausal women with breast cancer. Both drugs work by temporarily stopping the ovaries from making estrogen, which can fuel cancer growth. The trial will enroll 75 women an…

This study tests whether a new drug combination (lasofoxifene plus abemaciclib) works better than a standard combination (fulvestrant plus abemaciclib) for people with advanced ER+/HER2- breast cancer that has a specific gene change (ESR1 mutation). About 500 adults whose cancer …

This study tests two drugs together for people with advanced breast cancer that cannot be removed by surgery. SYS6023 targets a protein called HER3 on cancer cells, while KN026 targets HER2. The goal is to see if the combination is safe and shrinks tumors. About 36 adults with co…

This study tests a new treatment for people with metastatic breast or prostate cancer that has stopped responding to standard therapies. Participants receive infusions of their own immune cells that have been armed with a special antibody to help them find and attack cancer cells…

This phase 3 trial is testing trastuzumab deruxtecan (T-DXd), a drug that delivers chemotherapy directly to cancer cells with a specific marker (HER2). It includes 250 people with advanced breast cancer that has low or even no HER2, which is often harder to treat. Participants re…

This study looks at whether using radiotherapy before immunotherapy can help control advanced breast cancer that has spread or cannot be removed by surgery. About 150 adults who have already had radiotherapy will receive immunotherapy, and researchers will track how long it takes…

This phase II trial is testing a radioactive drug called 177Lu-DOTATATE in 10 people with stage IV or recurrent breast cancer. The drug seeks out cancer cells that have a specific receptor (SSTR2) and delivers radiation to kill them. The goal is to see if it can shrink tumors and…

This phase 2 trial is testing a combination of three drugs—alpelisib, L-NMMA, and nab-paclitaxel—in people with a rare, aggressive form of breast cancer called metaplastic breast cancer (MpBC) that has spread or is locally advanced. The study aims to find the best dose and see if…

This phase 2 trial tests whether delivering high-dose chemotherapy directly to the liver (using a special system) followed by standard cancer drugs works better than standard drugs alone for people with breast cancer that has spread mainly to the liver. About 90 participants will…

This early-stage trial tests the safety of a new drug called ERX-315 in 36 adults with advanced solid tumors (like breast, ovarian, or pancreatic cancer) that have stopped responding to standard treatments. Participants receive the drug intravenously twice a week at increasing do…

This early-stage trial tests the drug abemaciclib (a CDK4/6 inhibitor) given together with targeted radiation for people with metastatic HR+ HER2- breast cancer that has spread to bone. The main goal is to find the safest dose of abemaciclib when combined with radiation. About 28…

This early-phase trial is testing a new type of cell therapy called p95HER2.CAR-TECH2Me for people with advanced HER2-positive breast, gastric, or endometrial cancers that have spread. The treatment uses a patient's own immune cells, which are modified in a lab to better recogniz…

This phase 2 trial tests whether combining an immunotherapy drug (cemiplimab) with a radiation treatment (Y90 radioembolization) can help people whose breast cancer has spread to the liver. The treatment aims to boost the immune system to attack tumors while also delivering radia…

This early-phase trial tests AVA6000, a chemotherapy drug that is designed to activate only in tumors, potentially reducing side effects. About 158 adults with advanced solid tumors (like breast, ovarian, or salivary gland cancer) will receive the drug intravenously. The main goa…

This study tests whether adding surgery and targeted radiation to standard treatment helps people with HER2-positive breast cancer that has spread to up to 5 spots in the body. About 178 adults will be randomly assigned to receive either standard care alone or standard care plus …

This study is testing a procedure called cryoablation, which uses extreme cold to freeze and destroy breast cancer tumors. It is for people who cannot have surgery due to medical reasons or personal choice. Researchers will follow 100 participants to see how safe the freezing tre…

This phase 2 study tests estradiol, a form of estrogen, in postmenopausal women with advanced ER+ breast cancer that has stopped responding to other hormone therapies. The goal is to see if patients with a specific genetic change (ESR1 mutation) benefit more than those without it…

This phase 2 trial is testing the safety of abemaciclib (Verzenio) combined with hormone therapy in people aged 70 and older with hormone receptor-positive metastatic breast cancer that has worsened after prior treatment with a similar drug. The study will enroll 43 participants …

This study tests if axelopran, a drug used for opioid-induced constipation, can slow tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran daily for up to a year. Res…

This phase II trial is testing whether using specific genetic tests (Ki67 and Oncotype DX) can help doctors choose the best treatment before surgery for women with a common type of breast cancer (ER-positive, HER2-negative). The study includes 81 postmenopausal women with stage I…

This study tests an experimental drug called SHR-A1811 in people with advanced breast cancer that has spread to the brain. The goal is to see if the drug can shrink brain tumors. The trial enrolls 150 adults with HER2-positive or HER2-low breast cancer who have not had radiation …

This study is for people with metastatic breast cancer that has spread to the brain, with at least two brain tumors. Participants receive an immunotherapy drug called pembrolizumab every three weeks, plus a precise, one-time radiation treatment to just one of the brain tumors. Th…

This study tests whether a combination of three drugs (anastrozole, fulvestrant, and abemaciclib) can shrink or control tumors in people with a common type of advanced breast cancer (hormone receptor positive, HER2-negative). About 20 participants whose cancer has spread or retur…

This study is for people with certain types of breast cancer (HER2-positive or triple-negative) who have a complete response to initial drug therapy. It tests whether they can safely skip surgery and only receive radiation, or skip radiation if surgery shows no cancer left. For a…

This study explores whether women with recurrent breast cancer can safely have breast-conserving surgery and a second round of radiation instead of full mastectomy. It will enroll 60 patients who had prior radiation at least 3 years ago and have small, localized tumors. The goal …

This expanded access program provides DNG64-CAR-V, a gene therapy, to patients with advanced pancreatic cancer, sarcoma, or breast cancer who have exhausted standard treatments. The therapy is given intravenously or directly into tumors, alone or with other cancer drugs. Early st…

This study looks at how long hormone-blocking therapy given before surgery (neoadjuvant endocrine therapy) affects breast cancer in people with early-stage disease. About 90 participants will receive therapy for different lengths of time, from weeks up to a year. Researchers want…

This study tests whether giving a very focused, high-dose radiation treatment (SBRT) to all visible cancer spots can delay the cancer from getting worse in people with breast or lung cancer that has spread to 1-5 places. About 145 participants will either receive standard care al…

This study tests a combination of two drugs, tucatinib and trastuzumab, in people with a specific type of advanced breast cancer that has a mutation in the HER3 gene. The cancer must be HER2-negative and has already been treated with at least two prior chemotherapies. The goal is…

This study tests whether adding the immunotherapy drug pembrolizumab, with or without the targeted drug olaparib, to standard radiation therapy is safe and effective for people with metastatic triple-negative or hormone-receptor-positive/HER2-negative breast cancer. About 34 adul…

This study tests whether a special vacuum dressing (negative pressure therapy) can reduce wound complications like infection, reopening, or slow healing after complex breast cancer surgery with reconstruction. About 254 women with risk factors like obesity or smoking will be rand…

This early-stage trial is testing a treatment called X-PACT for people with advanced head and neck cancer, breast cancer, soft tissue sarcoma, or melanoma that has not responded to standard treatments. X-PACT involves injecting a drug called methoxsalen directly into the tumor an…

This study tests a new approach for metastatic breast cancer patients. Doctors take a biopsy of a tumor and grow it in the lab to create a 'tumorogram'—a map showing which drugs might work best. Then, patients receive a treatment chosen based on this map. The goal is to see if th…

This early-phase trial is testing a personalized vaccine made from a patient's own tumor, given alone or with immune-boosting drugs (pembrolizumab or ipilimumab), for triple negative breast cancer. The goal is to see if the vaccine is safe and can train the immune system to attac…

This study tests a new drug called HRS-8080 against standard treatments chosen by doctors for women with advanced breast cancer that has worsened after hormone therapy. About 240 women aged 18-75 will take part. The main goal is to see if HRS-8080 can delay cancer growth longer t…

This phase 2 trial is testing whether using gene tests (MammoPrint and BluePrint) to guide treatment can help people with a certain type of advanced breast cancer (HR+, HER2-negative) live longer. 64 participants will receive either chemotherapy (capecitabine) or hormone therapy …

This study tests a lower daily dose of the chemotherapy drug capecitabine in 40 patients aged 60 or older, or those who are frail, with advanced breast cancer. The goal is to see if this gentler dose can still shrink tumors while causing fewer side effects. Participants will take…

This study is for people with a common type of advanced breast cancer (ER-positive/HER2-negative) that cannot be removed by surgery or has spread. It tests a new drug called FWD1802 combined with other treatments to find the safest dose and see if it shrinks tumors. About 196 par…

This study tests whether a drug called azeliragon can reduce heart damage caused by chemotherapy in women with early-stage breast cancer. About 48 participants will receive azeliragon alongside their standard chemo to see if it is safe and helps protect the heart and thinking abi…

This Phase 2 trial tests a drug called patritumab deruxtecan in people with advanced hormone-receptor-positive breast cancer that has stopped responding to hormone therapy and chemotherapy. The drug is designed to seek out and destroy cancer cells that have a protein called HER3 …

This study tests whether a blood test measuring thymidine kinase activity (TKa) can help doctors decide early if a patient's breast cancer treatment is working. Patients with HR+ HER2- metastatic breast cancer start standard therapy with a CDK4/6 inhibitor and endocrine therapy. …

This study tests a new way of giving chemotherapy called adaptive therapy for people with advanced breast cancer that has gotten worse after standard treatments. The goal is to see if adjusting the dose over time can help control the cancer longer and with fewer side effects. Abo…

This study tests a treatment called TIL therapy for people with advanced breast cancer who have run out of standard options. Doctors take immune cells from a patient's own tumor, grow them in a lab, and put them back into the body to attack the cancer. The goal is to see if it is…

This Phase II trial tests whether a precise type of radiation called photon VMAT craniospinal irradiation can help people with breast or lung cancer that has spread to the fluid and lining around the brain and spinal cord. About 35 adults with this condition will receive radiatio…

This pilot study tests a new way of giving several already-approved chemotherapy drugs in a specific order to treat hormone-positive metastatic breast cancer. The idea is to hit the cancer with a 'first strike' and then a 'second strike' to make treatment more effective. The stud…

This study is testing a drug called trastuzumab deruxtecan in 118 adults with advanced breast cancer. The goal is to see how long the drug can keep the cancer from growing and what side effects occur. Participants must be in good overall health (ECOG 0-1) and not pregnant or nurs…

This study tests two experimental drugs, MHB036C and MHB039A, given together to people with advanced breast cancer or other advanced solid tumors that have spread. The goal is to see if the combination is safe and can shrink tumors. About 210 adults aged 18 to 75 with measurable …

This study tests whether giving radiation again after a second lumpectomy is safe for women with a common type of breast cancer (ER+HER2-). About 114 women who had radiation before and whose cancer came back at least 18 months later will receive targeted radiation over 3 weeks. T…

This phase 2 trial is testing a new, ultra-short radiation schedule for women with stage I-III breast cancer who have had a lumpectomy. Instead of the usual 3-4 weeks of daily radiation, this approach delivers the entire course in just 5 days. The goal is to see if this shorter t…

This early-phase study tests a new drug called OP-3136 in people with advanced breast, lung, or prostate cancers that have not responded to other treatments. The drug works by blocking certain enzymes that help cancer cells grow. The study will first find a safe dose, then test i…

This study tests whether precise radiation (SBRT) can treat a few growing tumors in patients with ER+ breast cancer that has spread, allowing them to continue their current medication longer. About 18 adults with limited disease progression will receive SBRT and be monitored. The…

This early-stage trial is testing a new drug called [177Lu]Lu-ABY-271, which delivers a small dose of radiation directly to HER2-positive breast cancer cells. The study will enroll 21 people with advanced or metastatic HER2-positive breast cancer to see if the drug is safe, toler…

This early-phase trial tests a personalized vaccine made from a patient's own tumor cells or donor cells. The cells are modified and killed in the lab, then injected under the skin to train the immune system to attack the cancer. The study includes 50 adults with metastatic melan…

This early-stage study is testing a new drug called RLY-2608, which is designed to block a specific mutant protein (PIK3CA) that helps some cancers grow. The trial includes people with advanced solid tumors or breast cancer that has not responded to other treatments. Participants…

This study tests proton radiation therapy for women with early-stage breast cancer. The goal is to see if targeting only the tumor area can keep cancer from coming back while causing fewer side effects. About 132 women aged 50 and older will take part. Researchers will track recu…

Researchers compare two tracers, indocyanine green (ICG) and blue patent dye, for locating lymph nodes during targeted axillary dissection in breast cancer patients who have received chemotherapy before surgery. The trial measures how often each tracer successfully identifies the…

This study looks at whether adding an MRI to the yearly mammogram can help find breast cancer earlier in women with dense breasts. Participants will have a mammogram and a risk score calculated from it. Those with a high risk score will be offered an MRI. The goal is to see if th…

This study is testing whether routine brain MRIs can find brain metastases in stage IV breast cancer patients who have no neurological symptoms. Researchers will scan 170 participants at the start and again at 6 months or when their cancer first progresses. The goal is to see how…

This study is testing whether a new blood test can screen for many types of cancer at once. Researchers will enroll 24,000 adults aged 45-75 who do not have cancer. Participants will be randomly assigned to one of two blood test groups or a control group. The goal is to see how w…

This early-phase study tests a new radioactive imaging agent called [68Ga]Ga-DWJ155 in 36 adults with advanced breast cancer or non-small cell lung cancer. The agent is designed to bind to a target on cancer cells and show up on PET scans, helping doctors see where the cancer has…

This study is testing a new, highly sensitive blood test to measure tiny particles called extracellular vesicles that are released by breast cancer cells. Researchers will compare levels in women with early or metastatic breast cancer to healthy controls. The goal is to see if th…

This phase I trial is testing a new radioactive tracer called [18F]FTT, which is used with PET/CT scans to find tumor cells in people with solid tumors, including breast, ovarian, and other cancers. The study will enroll 300 participants and aims to see how well the tracer highli…

This pilot study tests a special PET/MRI scan that uses a radioactive tracer to find HER2+ breast cancer that has spread to the brain. The scan aims to show whether the cancer cells take up the tracer, which might predict if they will respond to the standard drug trastuzumab deru…

This study is testing a new device that uses specially designed bacteria and laser technology to find and study rare tumor cells in the blood of breast cancer patients. The goal is to improve early detection and personalized treatment. The study will include 80 women with either …

This early study at Mayo Clinic is testing whether a new 3D ultrasound technique can better tell if lymph nodes under the arm contain cancer in people with breast cancer. About 55 adults who already need a lymph node biopsy or have a clip placed will get both standard 2D and the …

This study tests a new imaging approach for people with advanced breast or prostate cancer. It uses two radioactive tracers to find tumors that have a specific protein (GRPR). The goal is to see if this method is safe and can help doctors see where the cancer is in the body. Abou…

This study tests a new type of PET/CT scan that uses a radioactive tracer called 68Ga-ABS011 to detect HER2, a protein found on some cancer cells. The goal is to see if this scan can more accurately determine HER2 status in people with metastatic breast cancer or other solid tumo…

This study compares synthetic mammography (a 2D image made from 3D data) to standard digital mammography for detecting breast cancer. Researchers will review medical records from 750 women to see if the synthetic method works as well or better, with the added benefit of lower rad…

This study explores whether photoacoustic imaging—a technique that uses light and sound waves—can better detect breast cancer in women with dense breasts, where mammograms often fall short. Researchers will scan up to 400 women, including those with suspicious or confirmed breast…

This study enrolls 100 people with metastatic, hormone receptor-positive, HER2-negative breast cancer to compare different genetic testing methods for detecting PIK3CA mutations. Researchers will check how well newer DNA sequencing techniques match up with standard PCR tests. The…

This study is testing whether a blood test called a liquid biopsy can accurately detect breast cancer. Researchers will compare the blood test results with mammograms and standard tissue biopsies in 490 women. If the blood test works well, it could offer a less invasive way to sc…

Researchers at Mayo Clinic are testing a new breast ultrasound method to see if it can better detect breast cancer and measure how well a patient responds to treatment. The study will involve 550 adult volunteers with suspicious breast masses or biopsy-confirmed breast cancer. Pa…

This trial tests whether contrast-enhanced ultrasound (CEUS) combined with machine learning can more accurately tell if a breast mass is benign or malignant. 100 women with suspicious breast masses will receive CEUS with a contrast agent. The goal is to see if this approach can r…

This pilot study is testing a new type of PET scan that uses a tracer called [68Ga]Ga-PentixaFor to see if it can detect metastatic triple-negative breast cancer as well as or better than the standard FDG PET scan. The study will enroll 12 patients with metastatic triple-negative…

This study tests a special PET scan that uses a radioactive tracer to detect HER2 protein on cancer cells. The goal is to see if this scan can better identify which patients with metastatic breast cancer will benefit from a targeted drug called T-DXd. About 70 women with advanced…

This study tests whether taking low-dose aspirin can lower inflammation and reduce the risk of breast cancer in women who have had a baby within the last 10 years. About 60 women planning a breast biopsy will take aspirin and have blood and tissue samples checked for changes. The…

This study tests whether mobile health (m-Health) patient navigation—using phone apps for education, reminders, and motivation—can help more women in Kenyan primary care clinics get screened for breast cancer. The trial involves 800 women and aims to improve access to mammography…

This study tests whether adding high-dose omega-3 fatty acids to low-dose tamoxifen can lower breast cancer risk more than tamoxifen alone. It includes 66 overweight or obese postmenopausal women at increased risk for breast cancer. The goal is to see if the combination improves …

This phase II trial tests whether a natural supplement called fisetin, found in strawberries, combined with exercise can prevent frailty in postmenopausal women who have had early-stage breast cancer. Fisetin may help clear aging cells that cause inflammation and damage healthy t…

This study is for premenopausal women at higher-than-average risk for breast cancer. It tests whether a low dose of tamoxifen can safely reduce breast density, which is linked to cancer risk. About 200 women will take tamoxifen, and doctors will adjust the dose if needed to get t…

This study tests whether acolbifene or a low dose of tamoxifen can reduce breast cancer risk in premenopausal women at high risk. Both drugs block estrogen from reaching breast cells. Researchers will measure changes in breast tissue, blood, and mammograms over six months in 80 w…

This study tests whether a procedure called lymphovenous bypass, done before underarm lymph node removal, can prevent lymphedema (arm swelling) in patients with breast cancer or melanoma. About 252 participants will receive the bypass during their cancer surgery. Researchers will…

This study tests whether using quilting stitches (which attach skin to muscle) with just one drain under the arm works as well as using two drains after mastectomy. The goal is to prevent seroma (fluid buildup), infection, and pain. Sixty women having a modified radical mastectom…

This phase 2 trial tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in breast and ovarian cancer patients. About 86 participants will be randomly assigned to receive either a high or low dose of the juice du…

This study tests a community program to increase cancer screening rates among low-income women in Ohio. The program includes patient education, coaching calls, and community outreach. Researchers will compare screening rates between groups that start the program early versus late…

This study tests whether using community health advocates—people who encourage their friends and family—can increase screening for breast and lung cancer. Researchers will enroll 800 participants and provide educational materials, patient navigation, and surveys. The goal is to s…

This study tests whether a comprehensive program can prevent lymphedema (chronic arm swelling) in women undergoing lymph node removal for breast cancer. The program includes immediate lymphatic reconstruction during surgery, self-directed lymphatic massage, and regular arm measur…

This study tests a laser treatment for vaginal dryness in breast cancer survivors. Many survivors experience this side effect from cancer treatments like chemotherapy or hormone therapy. The trial will compare the laser to no treatment in 250 women to see if it improves symptoms.

This study tests a virtual group lifestyle program for women with metastatic breast cancer. The goal is to see if more support helps them stick with healthy habits like diet and exercise. One hundred women will take part, and researchers will track safety and how well they follow…

This study compares two exercise programs for women receiving chemotherapy for early-stage breast cancer. One program uses a fixed amount of walking each week, while the other adjusts the amount based on how each woman responds. The goal is to see which approach better improves c…

This study tests whether a 12-week home exercise program (aerobic and resistance training) can reduce fatigue in 80 people with metastatic breast cancer who are taking Enhertu. Participants exercise on their own, and researchers will measure changes in fatigue and how well people…

This study tests whether doing breathing exercises at home can help reduce heart and lung side effects in people being treated for breast, head/neck, or lung cancer. The exercises are designed to strengthen breathing muscles and may be easier than regular aerobic exercise for pat…

This study tests whether custom 3D-printed external breast prostheses improve comfort, fit, and emotional well-being for women who have had a mastectomy without reconstruction. Fifty participants will receive a personalized prosthesis made from 3D scans of their chest. The goal i…

This study tests whether megestrol acetate, a drug often used for appetite loss, can prevent or reduce severe tiredness in 132 women with advanced breast cancer who are starting a treatment called trastuzumab deruxtecan (T-DXd). Participants will receive either megestrol acetate …

This study tests two supportive care programs—meditation and discussion sessions—for people with advanced (stage IV) cancer and their family caregivers. Researchers want to see if these programs can reduce depressive symptoms and improve quality of life. About 400 patient-caregiv…

This trial tests a blended e-health program designed to help women with breast or gynecologic cancer cope with fear of their cancer returning or worsening. The program combines remote group sessions with online modules that teach skills to manage unhelpful thoughts and promote he…

This study compares two types of nerve blocks given before breast cancer surgery (modified radical mastectomy) to see which one helps patients recover better. Sixty women will receive either a newer block called subtransverse interligamentary plane block or the standard thoracic …

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if home treatment is preferred and improves satisfaction, while also checking safety. Participants will receive their usual cance…

This study tests whether adding telephone health coaching to a symptom management handbook helps reduce symptom burden and improve quality of life for people with metastatic breast, GI, or melanoma cancer and their caregivers. About 200 participants will be split into two groups:…

This study tests whether a special cooling cap can reduce hair loss in people with metastatic breast cancer who are receiving certain chemotherapy drugs. About 120 participants will either use the Paxman Scalp Cooling System or not, and researchers will compare hair loss rates an…

This study tests whether a virtual exercise and education program can help breast cancer patients maintain their fitness, heart health, and quality of life while undergoing chemotherapy. About 120 patients with stage I-III breast cancer will be enrolled. Participants will attend …

This study tests a culturally tailored web app (CAI) designed to help Asian American breast cancer survivors better manage cancer pain and related depressive symptoms. Researchers will enroll 300 women of Chinese, Korean, or Japanese descent who have had breast cancer and experie…

This study tests whether giving iron infusions can improve anemia (low red blood cells) in cancer patients receiving chemotherapy before surgery. About 34 adults with breast, lung, stomach, or urinary cancers will receive iron sucrose infusions. The goal is to raise hemoglobin le…

This study tests a remote coaching program called PRISM for people recently diagnosed with metastatic breast cancer. The program teaches stress management, goal setting, and coping skills through video sessions. Researchers want to see if it improves resilience and quality of lif…

This study compares two non-drug treatments—cognitive rehabilitation (brain training) and the Unified Barlow Protocol (emotional therapy)—against a waitlist group to see if they can reduce memory and thinking problems in breast cancer survivors. 123 survivors with mild to moderat…

This study tests whether a 16-week virtual exercise program can improve fitness, muscle strength, and quality of life in people with indolent (slow-growing) metastatic breast cancer. Participants work with a trainer three times a week via video calls. The goal is to see if exerci…

This study compares giving cancer treatment at home versus in the clinic for people with advanced cancers. The goal is to see if home treatment reduces stress, financial burden, and improves overall experience. About 220 participants will be randomly assigned to receive their reg…

This study tests a program called MAEva, which combines mindfulness and acceptance therapy, to see if it helps improve quality of life for people treated for non-metastatic breast cancer. About 190 participants will be randomly assigned to either the MAEva program or a discussion…

This study tests a decision aid for breast cancer patients experiencing nerve damage (numbness or tingling) from chemotherapy. The tool provides information about long-term nerve symptoms and helps patients discuss treatment priorities with their doctor. Researchers will enroll 2…

This study tests whether a simple breathing exercise using a small handheld device can strengthen breathing muscles and reduce shortness of breath in women receiving chemotherapy for early-stage breast cancer. About 58 participants will use the device daily and be monitored for c…

This study is testing a Chinese herbal cream (with 1% menthol) to see if it can temporarily relieve pain and itching on the chest after breast cancer radiotherapy. Forty women who have had a mastectomy and will receive radiation are being recruited. The cream is applied twice dai…

This study tests a telehealth program called ENGAGE for people with stage IV breast, prostate, lung, or colorectal cancer. The program helps manage symptoms like pain, fatigue, and distress that interfere with daily life. About 190 participants will be randomly assigned to ENGAGE…

This study tests whether a single dose of NPX-5 (a psilocybin drug) combined with talk therapy can reduce severe anxiety in people who have trouble adjusting to a cancer diagnosis. About 87 adults aged 18–80 with moderate-to-severe anxiety will receive one of three doses (25 mg, …

This study tests whether a smartphone app that lets cancer patients report their symptoms, combined with regular calls from a specially trained nurse, can help them better manage chemotherapy side effects and improve their quality of life. The study includes 414 adults with early…

This study tests whether Revaree Plus, a hyaluronic acid vaginal suppository, can improve vaginal dryness in women with hormone-receptor-positive breast cancer. About 60 participants will use the suppository for 8 weeks. Researchers will measure changes in vaginal health using a …

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate breast reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. The goa…

This study looks at whether a 16-week exercise program called Get Real and Heel can increase physical activity and improve well-being in people with metastatic breast cancer. Researchers will enroll 50 participants to see if the program is feasible and helps with symptoms, qualit…

This study tests whether using a frozen glove plus a tight surgical glove on one hand works better than a frozen glove alone to prevent nerve damage caused by the chemotherapy drug paclitaxel. About 60 women with early-stage breast cancer will be enrolled, each acting as their ow…

This study tests whether compounds from cannabis (CBD and THC) can reduce chronic nerve pain, tingling, and numbness caused by chemotherapy in breast and colon cancer survivors. About 120 people will take part and report their symptoms over 12 weeks. The goal is to find a better …

This study tests a five-session palliative care program called TARGET-PC for people with metastatic breast cancer and their caregivers. The goal is to help patients talk with their doctors about their goals and values for care, and to have those preferences documented. The study …

This study tests whether adapted Argentine Tango dancing can reduce nerve damage symptoms caused by breast cancer chemotherapy. About 140 survivors who completed taxane-based chemo at least 3 months ago will take 16 dance sessions over 8 weeks. Researchers will measure changes in…

This pilot study tests a program called ACCESS, where a community navigator helps Black and Latina women with metastatic breast cancer connect to supportive care and community resources. Participants receive six coaching sessions and monthly check-ins over 16 weeks. The goal is t…

This study explores whether regular video or phone check-ins between hospice patients with advanced breast cancer and their oncology team can improve the hospice experience. About 200 participants, along with their caregivers and nurses, will take part. The goal is to see if this…

This study collects spinal fluid, blood, saliva, and tumor samples from 139 adults with HER2-positive or triple-negative breast cancer that has spread to other organs but not yet to the brain. Researchers will analyze these samples for tumor DNA that might predict when the cancer…

This study is for people with metastatic breast cancer, including estrogen receptor-positive and triple-negative types. It uses biomarkers from tumors and blood to guide treatment choices, comparing how long the cancer stays controlled on the new therapy versus the previous one. …

This study looks at how the timing of a blood test that detects tumor DNA (ctDNA) affects understanding of prognosis and treatment choices in people with advanced HR+/HER2- breast cancer. Researchers will follow 400 participants to see how ctDNA levels and gene mutations relate t…

This study is collecting blood samples from 170 people with metastatic breast cancer to look for ESR1 gene mutations, which can make cancer resistant to hormone therapy. Researchers will compare these blood-based results with standard tissue tests. The goal is to better understan…

This study is observing about 800 adults with advanced breast cancer (HER2-positive, low, or ultralow) who are receiving the drug trastuzumab deruxtecan as part of their normal care in Germany. Researchers are tracking how long patients stay on the drug before switching treatment…

This study looks at whether starting with a lower dose of CDK4/6 inhibitor pills (palbociclib or ribociclib) and gradually increasing the dose helps older adults (age 65+) with metastatic breast cancer tolerate side effects better and stay on treatment longer. About 500 participa…

This study is creating a registry for people with a rare type of breast cancer called invasive lobular carcinoma that has spread. Researchers will collect data from about 12 participants to develop a new tool that better measures how well treatments are working. The goal is to im…

This study investigates whether adding environmental exposure risk assessments to standard care is useful and acceptable for women at average or high risk of breast cancer, as well as those diagnosed with early-onset breast cancer. Researchers will survey patients and providers a…

This Mayo Clinic study is recruiting 4,500 women who had a benign breast biopsy between 2002 and 2022. Researchers will examine tissue samples, mammograms, and genetic data to find clues about why some women later develop breast cancer. The goal is to improve risk prediction and …

This study tests whether a computer algorithm called ENLIGHT can help find better drug matches for people with advanced breast cancer that has stopped responding to standard treatments. About 175 adults with triple-negative or hormone-resistant breast cancer will have their tumor…

This pilot study will test a decision support tool called COAST, available as a booklet and website, designed to help people with stage IV breast cancer have better conversations with their doctors about treatment options. About 100 patients will use the tool and fill out surveys…

This study is creating a large collection of mammogram images, blood samples, and health information from 10,000 women getting routine screening mammograms. The goal is to build a resource for future research on breast cancer and women's health. Participants provide a blood sampl…

This study is testing a new web and mobile app called SHIELD, designed to support women with hormone receptor-positive breast cancer who are on long-term hormone therapy. The goal is to see if the app is easy to use and helpful for managing treatment. About 30 women will particip…

This study looks at whether an artificial intelligence (AI) tool can safely and accurately help breast cancer patients learn about their condition and treatment. About 35 adults with breast cancer will use the AI tool and answer surveys. The goal is to see if the tool is helpful …

This early-stage study tests a new type of marker that shows up better on ultrasound for people with breast cancer that has spread to lymph nodes. The marker is placed in the lymph node to help doctors find and remove the right node during surgery. The goal is to see if this mark…

This study is for breast cancer patients receiving certain chemotherapies that can harm the heart. Researchers want to see if a genetic marker called TRPC6 can predict who will develop heart problems. By analyzing blood samples, they hope to find early warning signs and ways to p…

This pilot study tests whether a special PET scan (FES-PET/CT) can help doctors find the best dose of tamoxifen for people with metastatic breast cancer that has an ESR1 mutation. These mutations can make standard tamoxifen doses less effective. The study will enroll 12 participa…

This pilot study is testing whether taking endocrine therapy in the morning or evening makes a difference for people with metastatic breast or prostate cancer. Fifty participants will be randomly assigned to take their medication either within an hour of waking or within an hour …

This study tests whether having a specialist review genetic test results and guide treatment decisions can increase the use of targeted therapies for people with advanced solid tumors, including breast, lung, colorectal, and bladder cancers. Participants will have their tumor or …

This study looks at whether a special fasting schedule (eating only dinner) can make PI3K inhibitor drugs work better against metastatic breast cancer. Researchers will check if patients can stick with the fasting plan and study blood samples to see how fasting affects cancer cel…

This study tests whether a blood test called DiviTum TKa can help doctors decide to order fewer scans and other tests for women with HR+ HER2- metastatic breast cancer. The trial will enroll 55 women starting a common first-line treatment. Doctors will fill out care plans before …

This study collects tumor tissue and blood samples from 10,000 women with breast cancer to build a large biorepository. Researchers will analyze these samples to find molecular markers that may predict how well a patient responds to therapy. The goal is to better understand breas…

This study looks at whether a program called 'Couples Coping Together Against Cancer' is helpful and practical for people with advanced cancers like stage IV breast cancer, glioblastoma, or lung cancer, and their partners. Researchers at City of Hope will enroll 160 couples to se…

This study looks at whether emotional distress (like anxiety or depression) affects how well first-line therapy works in people with metastatic breast cancer. Researchers will follow 1000 patients starting standard treatments based on their cancer type. The goal is to see if thos…

This study is collecting information on side effects from proton therapy in 5,000 adults with many types of cancer. Researchers will track both short-term and long-term side effects and link them to the details of each patient's treatment plan. The goal is to better predict who m…

This study follows 960 women at high risk for breast cancer to see if their diet's inflammatory potential is linked to cancer risk. Participants complete questionnaires and physical exams over time. The goal is to identify modifiable risk factors to improve prevention and early d…

This study explores whether using ChatGPT to create personalized educational materials helps patients better understand their breast reconstruction options before surgery. Participants scheduled for a breast reconstruction consultation are randomly assigned to receive either Chat…

This study is following over 6,000 breast cancer patients in Germany to see what treatments they actually receive in routine care and how they fare over time. Researchers are collecting data on treatment patterns, survival, and quality of life from patients with early and advance…

This study tracks whether women at moderately increased risk for breast cancer get recommended screening MRIs within a year of genetic counseling. Researchers will also explore what makes it easier or harder for them to follow through. About 150 women aged 30 to 75 with certain g…

This study looks at how well patients recover after mastectomy and tissue expander placement when they stay in a special 'Care Hotel' instead of a hospital or going straight home. The Care Hotel offers a comfortable room with nursing care during the day and 24-hour video monitori…

This study uses a special microscope called intravital microscopy to look at blood vessels inside solid tumors while patients are in surgery. Researchers want to see how these vessels work and how well they let blood and dye flow through. The goal is to learn whether tumor vessel…

This study is looking at whether a blood test called DiviTum TKa can predict when hormone-receptor-positive, HER2-negative metastatic breast cancer stops responding to treatment. About 100 participants will give blood samples before and during their standard therapy. The goal is …

This study compares three different blood tests (CellSearch, Parsortix, and SmartCatch) to see which one best detects circulating tumor cells in patients with metastatic breast or prostate cancer. Researchers will take blood samples from 54 patients before they start a new treatm…

This study gathers information from over 42,000 people with metastatic breast cancer treated at 18 French cancer centers since 2008. Researchers will look at how treatments have changed over time and how they affect survival. The goal is to learn from real-world data to improve f…

This observational study tracks 800 people with metastatic breast cancer to see if differences in HER2 levels across tumors affect how well trastuzumab deruxtecan works. Researchers will compare progression-free and overall survival based on HER2 patterns. The goal is to better u…

This study is testing a new radioactive tracer called [18F]FTT to see if it can help doctors see how well standard treatments are working in people with metastatic breast cancer. The tracer attaches to a protein in cancer cells and shows up on a PET scan. About 22 participants wi…

This study looks at how radiation therapy changes immune cells inside breast cancer tumors. Researchers want to see if radiation helps immune cells enter the tumor to fight cancer. The study involves 36 adults with invasive breast cancer who will receive radiation and have tumor …

This study is investigating whether a patient's body weight changes how the drug Trastuzumab-Deruxtecan (T-DXd) behaves in the body. Researchers will compare drug levels and side effects between normal-weight and overweight or obese patients with advanced breast cancer. The goal …

This study looks at how tamoxifen, a common breast cancer drug, affects certain immune cells called neutrophils. It focuses on a process where neutrophils release web-like traps that may cause side effects. Researchers will study blood samples from 290 women with ER+ breast cance…

This study is looking at how the immune system responds to breast and ovarian cancers. Researchers will analyze tumor and blood samples from 160 women before surgery to understand immune cell activity and find markers that might predict survival. The goal is to learn more about h…

This study is testing a device called ScreenCell that counts circulating tumor cells (CTCs) in a blood sample from breast cancer patients. Researchers want to see if changes in CTC numbers over time can help track how the cancer is progressing. The study will include 93 women wit…

This study observes 100 people in Korea with advanced HER2-positive breast cancer who take a drug called T-DM1 right after another drug, T-DXd, stops working. Researchers will track how long the cancer stays controlled and how well patients respond. The goal is to learn if this d…

This study looks at whether measuring body composition (like body fat) before and after breast reconstruction surgery can help predict outcomes. Researchers will enroll 40 women with breast cancer who are having a mastectomy followed by immediate reconstruction. The goal is to se…

This study tests whether a special PET scan (EstroTEP) and blood tests can help doctors pick the best second-line treatment for people with ER-positive, HER2-negative metastatic breast cancer. About 300 participants will be assigned to either endocrine therapy or chemotherapy bas…

This study is a registry that collects information from 1867 people with advanced breast cancer that cannot be removed by surgery or has spread. Researchers will track different breast cancer subtypes and patient characteristics to better understand the disease in real-world sett…

This early study tests if a portable device that creates electric fields is safe and practical for people with breast or lung cancer that has spread to the lining of the spine. Only 5 participants will wear the device for at least 28 days. The goal is to see if the treatment is t…

This study is looking at how cancer genetic testing works in people from different ethnic backgrounds. Researchers will collect blood samples and genetic information from 1,800 adults with various solid tumors. The goal is to find cancer-related gene mutations and see if current …

This study from Mayo Clinic interviews breast cancer patients who are undergoing or have recently finished radiotherapy. The goal is to learn about their physical, emotional, and social experiences with radiation dermatitis (skin irritation from radiation). By collecting these pe…

This study is tracking 1,500 Swedish patients with metastatic breast cancer who are taking palbociclib as part of their treatment. Researchers want to see how long patients stay on the drug, what their characteristics are, and how they fare over time. It's an observational study,…

This pilot study looks at whether changes in gut bacteria are linked to fatigue and nausea in women with early-stage breast cancer undergoing chemotherapy. Researchers will collect stool and blood samples and have participants fill out questionnaires before and after treatment. T…

This study examines DNA from 162 breast cancer patients who received chemotherapy and either did or did not develop congestive heart failure. Researchers want to find specific gene changes that might increase the risk of heart problems after treatment. The goal is to better under…

This study examines DNA from 575 breast cancer patients who received the chemotherapy drug paclitaxel. Researchers want to find genetic differences that explain why some patients develop nerve damage (peripheral neuropathy) while others do not. The goal is to identify biomarkers …

This study examines DNA from 354 breast cancer patients who took the drug bevacizumab. Some developed severe high blood pressure, while others did not. Researchers will compare their DNA to find genetic changes that might raise the risk of this side effect. The goal is to better …

This study looks at whether a deep inspiration breath-hold (DIBH) technique during radiation therapy for breast cancer keeps the radiation dose on target and protects nearby organs. About 25 women who have had breast cancer surgery will be observed. The goal is to see if the plan…

This study looks at what helps and what is hard for people with advanced breast cancer, and what kind of support they still need. Researchers will talk to 50 patients and review their medical records to understand their experiences. The goal is to learn how to improve care and su…

This study tests whether a computer-generated character (PERLA) can effectively educate cancer patients about genetic testing, compared to a human genetics counselor. Researchers will enroll 800 people with certain cancers, including breast, ovarian, pancreatic, and prostate canc…

This study follows 2,000 adults with newly diagnosed breast, colorectal, lung, melanoma, or lymphoma cancer who are receiving chemotherapy or immunotherapy. Researchers will track whether using cannabis or cannabinoids helps with symptoms like pain or nausea over time. No treatme…

This study is testing whether a blood test that looks for cancer cells and genetic material can help doctors decide on treatments for metastatic breast cancer. About 187 adults with advanced breast cancer will participate. The goal is to see if the test results change how doctors…

This study looks at whether it is possible to take multiple tissue samples (biopsies) from different tumor sites in people with metastatic breast cancer at different times during treatment. The goal is to learn how cancers change and become resistant to therapy. About 200 adults …

This study collects tumor samples and medical information from 2000 people with breast cancer that has spread or come back. The goal is to create a resource for researchers to learn more about how the disease progresses and responds to treatments. No new treatments are tested her…

This study is testing whether a web and mobile phone program can help Hispanic women who have had breast, uterine, or ovarian cancer, along with their adult daughters, eat better and be more active. The program includes 8 online modules. The main goal is to see if the program is …

This study compares two types of scans—FDG-PET/CT and standard CT—to see which one better tracks breast cancer that has spread. Researchers want to know if the newer scan can find cancer growth earlier, helping doctors start new treatments sooner and potentially extend patients' …

This study is testing a patient navigation program for women newly diagnosed with breast cancer. The program helps patients understand their care options, connect to support services, and manage barriers like transportation or finances. Researchers want to see if this approach im…

This study is collecting blood and tumor samples from 13,500 breast cancer patients, both early-stage and advanced/metastatic. The goal is to discover biomarkers that can predict how well a treatment will work and to improve overall healthcare quality. Researchers will analyze ge…

This study looks at whether giving doctors the molecular subtype of a patient's metastatic breast cancer helps them pick more effective treatments. It involves 500 adults with metastatic breast cancer who are starting or have had one prior treatment. The main goal is to see how o…

This study tests a new device that prepares blood samples to look for cancer cells and DNA. Researchers will collect blood from 20 healthy volunteers and 25 people with advanced breast cancer. The goal is to see if the device works well for liquid biopsy, a less invasive way to d…

The CATCH trial is a large observational study for people with metastatic breast cancer. It uses advanced genetic testing on tumor biopsies to find unique biomarkers and drug targets. The goal is to create a precision medicine platform that helps guide patients toward the most pr…

This study is testing whether certain substances in the blood can help predict where breast cancer might spread. Researchers will measure levels of a protein called PTEN and specific microRNAs in blood samples from 160 women: 80 with metastatic breast cancer, 40 with early-stage …

This study tests whether an online self-monitoring platform helps patients with lung, colorectal, breast, or prostate cancer track medication safety events and concerns while taking oral anticancer drugs at home. Eighty adult patients currently on active cancer treatment will use…

This study looks at how sleep changes in women with early-stage breast cancer during treatment. Researchers will track sleep patterns and check for links to stress, social support, and living environment. About 100 participants will wear a sleep monitor and answer surveys before,…

This study is for people with advanced breast cancer who are about to start treatment with the drug T-DXd. The goal is to find markers in the blood that could predict serious side effects, like lung inflammation. By collecting blood samples before and during treatment, researcher…

This study looks at whether eating white button mushrooms can lower inflammation and improve immune function in obese postmenopausal women who have a high risk of breast cancer. Researchers will measure changes in immune cells and inflammatory markers in the blood. The goal is to…

This early-phase trial is testing two new antibody fragments that are designed to attach to a sugar molecule found on many solid tumors. The fragments are labeled with a radioactive tracer so they can be seen on PET/CT scans. The study aims to see where these fragments go in the …

This study looks at whether holding a deep breath during breast cancer radiation therapy can lower the amount of radiation reaching the heart. Researchers will compare heart radiation doses in 400 women who use a special breathing device versus those who breathe normally. The goa…

This study is looking at proteins and genes in breast cancer tumors from 1,780 patients. Researchers want to understand how breast cancer progresses and why it sometimes comes back. By comparing primary and recurrent tumors, they hope to find markers that could predict disease ou…

This study will look at medical records of 60 Russian patients with advanced HER2-positive breast cancer who have received trastuzumab deruxtecan. Researchers want to see how long the drug keeps cancer from growing and how safe it is. The goal is to understand how well this treat…

This study looks at how well certain markers in tumors can predict whether a type of targeted cancer treatment called antibody-drug conjugates (ADCs) will work. About 400 adults with advanced breast, stomach, bladder, or lung cancer will provide tumor samples before and after tre…

This study is developing and testing a printed decision aid for women diagnosed with early-stage breast cancer. The tool is designed to help them make informed choices about their treatment. Researchers will compare how well women who receive the aid feel about their decisions ve…

This study tests a post-treatment support program for breast cancer survivors in Western New York. The program includes group sessions and one-on-one mentoring with a long-term survivor to help with self-assessments and connecting to resources. The goal is to see if this program …

This study follows 700 adults with advanced or metastatic breast cancer who are taking CDK4/6 inhibitors (ciclib drugs). Researchers collect blood, tissue, and fluid samples to understand how the cancer responds, why resistance develops, and how well patients do over time. The go…

This study is testing whether an artificial intelligence (AI) tool can help match cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to…

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking (cognitive) changes in breast cancer survivors. Researchers will enroll 30 racially diverse women aged 40 and older who are at least five years past diagnosis. Participants comp…

This study looks at heart problems in people with HER2+ breast cancer that has spread. All participants are taking trastuzumab-based treatment. The main goal is to see how often heart issues occur, especially in those also taking beta blockers or similar heart medications. A smal…

This study asks 15 doctors, nurses, and physician assistants about a new computer tool that estimates how long patients with metastatic breast cancer might live. The goal is to see if the tool is easy to use and helpful for discussing end-of-life care. Researchers will interview …

This study looks at 1500 women treated for breast cancer in India between 2017 and 2018 to see how many stopped coming to follow-up visits. Researchers will call or message those who are 'lost to follow-up' to ask about their health and find out why they stopped. The goal is to l…

This study is tracking 2,000 people with metastatic breast cancer to understand how the cancer changes over time and in response to treatment. Researchers will analyze tumor and blood samples to find genetic markers that predict which therapies work best. The goal is to develop b…

This study is testing whether a special type of PET-CT scan (F-18 FDG PET-CT) can better track how well treatment is working in people with advanced breast cancer compared to standard imaging like CT scans. Researchers will follow 100 patients for 48 weeks after they start their …