New hope for hard-to-treat breast cancer: targeted drug takes on standard therapy
NCT ID NCT06486883
First seen Nov 01, 2025 · Last updated May 21, 2026 · Updated 28 times
Summary
This study tests a targeted drug, trastuzumab deruxtecan (T-DXd), against the usual treatment (a CDK4/6 inhibitor plus hormone therapy) for people with a specific type of advanced breast cancer. The cancer must be hormone receptor-positive, HER2-low or ultralow, and have a non-luminal gene pattern. About 200 adults will take part to see which approach works better at delaying cancer growth. The trial is currently recruiting.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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A.O.U. Ospedali Riuniti di Ancona
RECRUITINGAncona, 60126, Italy
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AOU Careggi
RECRUITINGFlorence, 50134, Italy
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Algemeen Ziekenhuis Klina
RECRUITINGBrasschaat, Belgium
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Azienda Ospedaliero- Universitaria Maggiore Della Carita
RECRUITINGNovara, 28100, Italy
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CHU Helora - Hopital de Mons
RECRUITINGMons, Belgium
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CHU Lyon Sud
RECRUITINGLyon, France
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CHU Saint Etienne
RECRUITINGSaint-Priest-en-Jarez, 42055, France
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Centro Oncológico de Galicia
RECRUITINGA Coruña, 15009, Spain
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Centro di Riferimento Oncologico di Aviano
RECRUITINGAviano, 33081, Italy
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Cliniques universitaires Saint-Luc
RECRUITINGWoluwe-Saint-Lambert, Belgium
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Complejo Hospitalario Universitario A Coruña (CHUAC)
RECRUITINGA Coruña, 15006, Spain
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Complejo Hospitalario Universitario de Santiago (CHUS)
RECRUITINGSantiago de Compostela, 15706, Spain
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Complejo Hospitalario de Jaén
RECRUITINGJaén, Jaén, 23007, Spain
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Federico II Napoli
RECRUITINGNaples, 80131, Italy
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Fondazione Policlinico Universitario Agostino Gemelli
RECRUITINGRoma, 00168, Italy
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Hospital Arnau de Vilanova de Valencia
RECRUITINGValencia, Spain
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Hospital Beata María Ana
RECRUITINGMadrid, 28007, Spain
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Hospital Clínic i Provincial de Barcelona
RECRUITINGBarcelona, 08036, Spain
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Hospital Clínico San Carlos
RECRUITINGMadrid, 28040, Spain
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Hospital Clínico Universitario Lozano Blesa
RECRUITINGZaragoza, 50009, Spain
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Hospital Clínico Universitario Virgen de la Arrixaca
RECRUITINGMurcia, Murcia, 30120, Spain
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Hospital Clínico Universitario de Valencia
RECRUITINGValencia, Valencia, 46010, Spain
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Hospital QuirónSalud Zaragoza
RECRUITINGZaragoza, 50012, Spain
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Hospital Quirónsalud Sagrado Corazón
RECRUITINGBarcelona, Barcelona, 41013, Spain
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Hospital San Pedro de Alcántara
RECRUITINGCáceres, Cáceres, 1003, Spain
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Hospital Universitari Dexeus
RECRUITINGBarcelona, 08028, Spain
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Hospital Universitari Sant Joan de Reus
RECRUITINGReus, Tarragona, 43204, Spain
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Hospital Universitari i Politècnic La Fe
RECRUITINGValencia, 46026, Spain
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Hospital Universitario Arnau de Vilanova de Lleida
RECRUITINGLleida, 25198, Spain
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Hospital Universitario Clínico San Cecilio
RECRUITINGGranada, Granada, 18007, Spain
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Hospital Universitario Doce de Octubre
RECRUITINGMadrid, 28041, Spain
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Hospital Universitario Puerta de Hierro Majadahonda
RECRUITINGMajadahonda, Madrid, 28222, Spain
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Hospital Universitario Ramón y Cajal
RECRUITINGMadrid, Madrid, 28034, Spain
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Hospital Universitario San Juan de Alicante
RECRUITINGAlicante, 03550, Spain
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Hospital Universitario Virgen Macarena
RECRUITINGSeville, 41009, Spain
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Hospital Universitario Virgen de la Victoria
RECRUITINGMálaga, 29010, Spain
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Hospital Universitario de Basurto
RECRUITINGBilbao, 48013, Spain
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Hospital de Cascais
RECRUITINGAlcabideche, 2755-009, Portugal
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Institut Català d' Oncologia Badalona (ICO)
RECRUITINGBadalona, 08916, Spain
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Institut Català d' Oncologia Girona (ICO)
RECRUITINGGirona, Girona, 17007, Spain
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Institut Curie
RECRUITINGParis, France
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Instituto Europeo di Oncologia
RECRUITINGMilan, 20141, Italy
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Instituto Portugues Oncologia de Porto (IPO)
RECRUITINGPorto, Portugal
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Instituto Valenciano de Oncología (IVO)
RECRUITINGValencia, 46009, Spain
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Istituto Nazionale Tumori Irccs "Fondazione G Pascale"
RECRUITINGNaples, 80131, Italy
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Klinikum Worms - Frauenklinik
RECRUITINGWorms, 67550, Germany
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Medtrials Sp. z o.o.
RECRUITINGKrakow, Poland
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Oncologia medica AUSL Piacenza
RECRUITINGPiacenza, 29100, Italy
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Ospedale Policlinico San Martino
RECRUITINGGenova, 16132, Italy
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Ospedale San Gerardo
RECRUITINGMonza, 20900, Italy
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Ospedale di Macerata
RECRUITINGProvince of Macerata, 62100, Italy
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UOMI Cancer Center
RECRUITINGBarcelona, 08017, Spain
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Unidade Local de Saúde Amadora/Sintra - Hospital Fernando da Fonseca
RECRUITINGAmadora, 2720-276, Portugal
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Unidade Local de Saúde de Santa Maria
RECRUITINGLisbon, 1649-035, Portugal
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Unidade Local de Saúde de Trás-os-Montes e Alto Douro
RECRUITINGLordelo, Vila Real District, 5000-508, Portugal
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Unidade Local de Saúde do Alto Ave
RECRUITINGBraga, Portugal
Conditions
Explore the condition pages connected to this study.