Medsir

This study tests whether adding everolimus to elacestrant can help people with a certain type of advanced breast cancer (ER+/HER2-, with an ESR1 mutation) live longer without their cancer growing. About 240 adults whose cancer has worsened after standard treatments will receive e…

This study tests a targeted drug, trastuzumab deruxtecan (T-DXd), against the usual treatment (a CDK4/6 inhibitor plus hormone therapy) for people with a specific type of advanced breast cancer. The cancer must be hormone receptor-positive, HER2-low or ultralow, and have a non-lu…

This study tests a drug called repotrectinib in people with a specific type of lung cancer (ROS1-positive non-small cell lung cancer) that has spread to the brain. The goal is to see if the drug can shrink or control brain tumors. About 20 adults will take the drug by mouth, and …

This study tests whether giving the drug niraparib again after surgery can help women with ovarian cancer whose disease has come back in just a few spots. About 30 participants will take niraparib pills for as long as they work. The goal is to see if this approach can delay the c…

This study is for people with a common type of early breast cancer (HR+/HER2-) who have had surgery. Researchers will regularly test their blood for tiny bits of tumor DNA (ctDNA) to see if the cancer is coming back before it shows up on scans. If the test is positive, participan…