New radiation technique aims to fight brain metastases while protecting memory
NCT ID NCT06518057
First seen Jan 08, 2026 · Last updated Jun 21, 2026 · Updated 29 times
Summary
This phase 2 trial is testing a type of radiation called craniospinal irradiation that avoids the hippocampus, a brain area key for memory. It is for people with breast or lung cancer that has spread to the fluid and lining around the brain and spinal cord. The goal is to see if this approach can control the cancer longer than standard radiation while causing fewer thinking and memory side effects.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fred Hutch/University of Washington Cancer Consortium
RECRUITINGSeattle, Washington, 98109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of California San Francisco
NOT_YET_RECRUITINGSan Francisco, California, 94143, United States
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
craniospinal irradiation with hippocampal avoidance (proton therapy or VMAT)
What this could lead to
If it works, this could offer a way to control cancer spread in the brain and spine while reducing memory and thinking problems from radiation.
What could go wrong
This is a small, early-phase trial with only 22 participants, so results may not apply widely. The treatment may still cause side effects or fail to improve survival.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.