New triple-drug attack targets hard-to-treat breast cancer
NCT ID NCT05660083
First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 29 times
Summary
This study tests a three-drug combination (alpelisib, L-NMMA, and chemotherapy) in people with a rare, aggressive type of breast cancer called metaplastic breast cancer that has spread or is locally advanced and hasn't responded to prior treatments. The goal is to see if adding these two drugs to standard chemo can shrink tumors or slow the cancer. About 36 adults will take part, receiving treatment in 3-week cycles until the cancer worsens or side effects become too severe.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Houston Methodist Neal Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact
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National Institute of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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