New hope for hard-to-treat breast cancer: experimental combo enters human trials
NCT ID NCT06756932
First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 27 times
Summary
This early-stage study tests a new drug called BGB-21447, which blocks a protein that helps cancer cells survive. It is given together with standard hormone therapy (fulvestrant) and sometimes another targeted drug (BGB-43395) to adults with HR+/HER2- breast cancer that has spread. The main goals are to check safety and find the best dose, while also seeing if the combination shrinks tumors. About 120 participants will take part.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Calvary Mater Newcastle
RECRUITINGWaratah, New South Wales, NSW 2298, Australia
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Fred Hutchinson Cancer Research Center
RECRUITINGSeattle, Washington, 98109-4433, United States
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Fudan University Shanghai Cancer Centerpudong
RECRUITINGShanghai, Shanghai Municipality, 201321, China
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Hoag Memorial Presbyterian
RECRUITINGNewport Beach, California, 92663-4162, United States
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Linear Clinical Research
RECRUITINGNedlands, Western Australia, WA 6009, Australia
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Md Anderson Cancer Center
RECRUITINGHouston, Texas, 77030-3907, United States
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Peter Maccallum Cancer Centre
RECRUITINGMelbourne, Victoria, VIC 3000, Australia
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Saint Vincents Hospital Sydney
RECRUITINGDarlinghurst, New South Wales, NSW 2010, Australia
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Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
RECRUITINGHangzhou, Zhejiang, 310016, China
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Sun Yat Sen Memorial Hospital, Sun Yat Sen University (South)
RECRUITINGGuangzhou, Guangdong, 510245, China
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Sunshine Coast University Private Hospital
RECRUITINGBirtinya, Queensland, QLD 4575, Australia
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The First Affiliated Hospital of Nanchang University Branch Donghu
RECRUITINGNanchang, Jiangxi, 330006, China
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The First Affiliated Hospital of Zhengzhou University
RECRUITINGZhengzhou, Henan, 450052, China
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Tianjin Medical University Cancer Institute and Hospital
RECRUITINGTianjin, Tianjin Municipality, 300060, China
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University of Iowa Hospitals and Clinics
RECRUITINGIowa City, Iowa, 52242-1009, United States
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Western Health Sunshine Hospital
RECRUITINGSt Albans, Victoria, VIC 3021, Australia
Conditions
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