HORMONE-RECEPTOR-POSITIVE BREAST CANCER

This is the first study in people to test a new drug called XB010 for advanced solid tumors that have stopped responding to other treatments. The main goals are to find a safe dose and see if the drug, given alone or with another cancer drug, shows early signs of fighting the can…

This study is testing if a weight loss medication called tirzepatide can help prevent breast cancer from coming back. It will involve 40 people who have completed treatment for early-stage, hormone-positive breast cancer and are overweight. Researchers want to see if losing weigh…

This early-stage study aims to find safe doses and gather initial evidence on whether a new drug called BGB-43395 can help control advanced cancers. The trial will enroll about 300 people with hormone-positive, HER2-negative breast cancer that has spread, as well as other solid t…

This study is testing whether a combination of three existing drugs can help control advanced breast cancer that has spread and is fueled by hormones. It is for people newly diagnosed with this advanced stage or whose cancer returned after a long period of stability. The goal is …

This early-stage study aims to find the safest and most effective dose of the drug abemaciclib when given alongside radiation therapy to treat bone metastases in people with advanced, hormone-sensitive breast cancer. The study will enroll 28 adults whose cancer has spread and who…

This study is testing whether adding the drug ribociclib to standard hormone therapy can better prevent breast cancer from returning in patients who have already had a local recurrence surgically removed. The trial will enroll 200 adults with hormone-sensitive, HER2-negative brea…

This study is testing whether a combination of two targeted drugs (pertuzumab and trastuzumab) plus hormone therapy, given after surgery, can help prevent cancer from returning in people with early-stage, hormone-positive, HER2-positive breast cancer. About 375 participants will …

This is an early-stage study testing a new oral drug called BG-68501 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined with…

This study is testing whether the drug sacituzumab govitecan can help control metastatic breast cancer in people who have already received another targeted treatment called trastuzumab deruxtecan. The trial will enroll 75 adults with hormone receptor-positive, HER2-low breast can…

This early-stage study is testing whether new drug combinations are safe for people with advanced hormone-positive breast cancer that has spread. Researchers will give 120 participants either two or three drugs together to see how well they're tolerated and if they help shrink tu…

This study is testing a personalized approach to reduce chemotherapy for women with a common type of early-stage breast cancer. It uses a simple blood test to see if a targeted pill (dalpiciclib) combined with hormone therapy works as well as standard chemo before surgery. The go…

This study is testing the safety and effectiveness of a new drug, VS-6766, when combined with two existing breast cancer drugs (abemaciclib and fulvestrant). It is for people with advanced HR+/HER2- breast cancer that has worsened despite prior standard treatments. The goal is to…

This study is testing which of four different hormone therapy combinations works best for men with early-stage breast cancer before surgery. About 60 men will receive one of the treatment combinations for about 4 months to see how their cancer responds. Researchers want to find b…

This study is testing if combining two drugs, capecitabine and elacestrant, works better than just capecitabine alone for people with advanced, hormone-sensitive breast cancer. It's for patients whose cancer has stopped responding to a common class of prior medications. The main …

This study is testing a new drug called EP0062, both alone and combined with standard treatments, for women with a specific type of advanced breast cancer that has come back after prior therapy. The main goals are to find the safest and most effective dose and to see how well the…

This is an early study to test the safety of a new two-part treatment for people with advanced breast cancer that has spread or cannot be removed by surgery. The treatment involves giving patients their own modified immune cells (CLBR001), followed by a biologic drug (ABBV-461) t…

This study is testing whether a vaginal suppository called Revaree Plus can improve vaginal health for women experiencing dryness and discomfort during breast cancer treatment. Researchers will enroll 60 women with hormone-receptor positive breast cancer who have completed primar…

This study aims to find out if regular brain MRI scans can detect cancer that has spread to the brain in patients with advanced breast cancer who have no neurological symptoms. Researchers will enroll 170 patients with stage IV breast cancer to see how often these scans find hidd…

This study is testing a blood test called DiviTum®TKa to see if it can predict early whether standard hormone-based treatments for advanced breast cancer will stop working. Researchers will measure a specific marker in the blood of 100 patients with hormone-positive, HER2-negativ…