New hope for advanced cancers: XB010 trial launches

NCT ID NCT06545331

Recruiting now Disease control Sponsor: Exelixis Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 33 times

Summary

This early-phase study tests a new drug called XB010, alone or with another drug (pembrolizumab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and check for any side effects. About 396 adults with cancers like lung, breast, or head and neck cancer may join.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Exelixis Clinical Site #1
RECRUITING

Austin, Texas, 78758, United States
Exelixis Clinical Site #10
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Washington D.C., District of Columbia, 20007, United States
Exelixis Clinical Site #11
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Fairfax, Virginia, 22031, United States
Exelixis Clinical Site #12
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Atlanta, Georgia, 30322, United States
Exelixis Clinical Site #13
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London, England, W1G 6AD, United Kingdom
Exelixis Clinical Site #14
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Manchester, England, M20 4BX, United Kingdom
Exelixis Clinical Site #15
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Chicago, Illinois, 60637, United States
Exelixis Clinical Site #16
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London, England, W1T 7HA, United Kingdom
Exelixis Clinical Site #17
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Leicester, England, LE1 5WW, United Kingdom
Exelixis Clinical Site #18
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Orlando, Florida, 32827, United States
Exelixis Clinical Site #19
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Los Angeles, California, 90095, United States
Exelixis Clinical Site #2
RECRUITING

Fairfax, Virginia, 22031, United States
Exelixis Clinical Site #3
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Huntersville, North Carolina, 28078, United States
Exelixis Clinical Site #4
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Irvine, California, 92618, United States
Exelixis Clinical Site #5
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St Louis, Missouri, 63110, United States
Exelixis Clinical Site #6
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Oklahoma City, Oklahoma, 73104, United States
Exelixis Clinical Site #7
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Dallas, Texas, 74246, United States
Exelixis Clinical Site #8
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Houston, Texas, 77030, United States
Exelixis Clinical Site #9
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Nashville, Tennessee, 37203, United States

Conditions

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ESOPHAGEAL SQUAMOUS CELL CANCER HEAD AND NECK SQUAMOUS CELL CANCER HEAD AND NECK SQUAMOUS CELL CANCER HORMONE RECEPTOR-POSITIVE BREAST CANCER LOCALLY ADVANCED OR METASTATIC SOLID TUMORS NSCLC (NON-SMALL CELL LUNG CANCER) TRIPLE NEGATIVE BREAST CANCER (TNBC)