Psychiatric disorder

Researchers are testing a new enzyme replacement therapy called GNR-055 in people with Hunter syndrome (MPS II), a rare inherited disorder that causes harmful sugar molecules to build up in the body. The trial enrolls about 32 patients, including those who have never had enzyme t…

This trial tests whether allowing adults in Basel to buy cannabis from pharmacies, instead of the illegal market, changes how much they use and their mental and physical health. About 374 adults who use cannabis at least monthly will be randomly assigned to either regulated pharm…

This study tests a program called Mastering the World of Work (MWW) designed to help people with serious mental illness improve their job outcomes. The program focuses on building metacognitive skills — the ability to understand one's own thoughts and others' perspectives — throu…

This study tests whether giving low-income parents of toddlers with sleep and behavior problems a choice of coaching program leads to better outcomes than being assigned one. Families are randomly placed into one of four groups: sleep coaching, behavior coaching, a choice between…

This study tests a 6-month community-based program that pairs university students with Latinx immigrants and African refugees to provide mutual learning, resource help, and social support. The goal is to see if this approach can reduce psychological distress, financial problems, …

This trial investigates the long-term safety of ecopipam, a drug that blocks dopamine D1 and D5 receptors, in children, adolescents, and adults with Tourette syndrome. Participants who completed a prior study may enroll and receive ecopipam for up to 24 weeks or longer. The main …

This trial compares two group-based education programs for people with serious mental illness who also have chronic physical conditions like diabetes or heart disease. One program, Integrated Illness Management and Recovery (I-IMR), covers both mental and physical health self-man…

This study tests whether a digital expert team can help people on long-term sick leave with muscle or common mental health issues return to work. Participants fill out a digital questionnaire and have a video meeting with their doctor and a team of specialists who then create a p…

This phase 3 study tests whether donanemab, an antibody given through an IV, can safely slow cognitive decline in 1500 people with early Alzheimer's. Participants receive either the drug or a placebo for up to 93 weeks. The main goal is to measure changes in thinking and daily fu…

This study tests whether a 12-week mobile program can improve cognitive function and motivation in people aged 15–40 who have had psychosis symptoms for less than five years. Participants will either use the mobile training or continue their usual care, and researchers will compa…

This study tests whether one or two doses of psilocybin, the active ingredient in magic mushrooms, combined with talk therapy, can help people with treatment-resistant depression. Participants are adults aged 18 to 65 whose depression has not improved with standard treatments. Re…

This study tests different dosing schedules of the drug donanemab in about 1,175 people with early symptomatic Alzheimer's disease. The goal is to find a regimen that lowers brain amyloid plaques while reducing the risk of a side effect called ARIA-E (brain swelling or small blee…

This study compares a new blended therapy (online sessions plus in-person visits) to standard in-person therapy for teens with conduct disorder or antisocial behavior. Researchers want to see if the blended approach works just as well at reducing aggression, delinquency, and out-…

This study tests whether intensive home-based psychiatric treatment can help children and teens with mental health disorders as an alternative to being in the hospital. Over 3 months, participants receive 3 to 7 home visits per week from a team of doctors, therapists, and other s…

This study tests whether semaglutide (Wegovy), a weekly injection for weight loss, can help people in secure mental health care who have gained weight from antipsychotic drugs like clozapine or olanzapine. About 20 adults with a BMI of 35 or higher will receive the drug along wit…

This study tests whether a 6-week exercise program, done twice a week, can improve physical and mental health in 100 adults with severe mental illness. Participants are randomly assigned to either usual care or usual care plus the exercise program. The goal is to see if exercise …

This study tests a program called BECOME, where community health workers in Nepal teach stress reduction, behavioral activation, and motivational interviewing to adults aged 40 and older who have both a mental health condition (like anxiety or depression) and a chronic disease (l…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study compares two approaches to help people who are homeless or at risk of homelessness quit smoking: cytisine (a plant-based pill) versus nicotine replacement therapy (like mouth spray, patches, or gum). Both groups also get counseling. The goal is to see which strategy wo…

This study tests a new way of delivering mental health and addiction services to youth aged 14-17. Instead of standard hospital outpatient care, an integrated team offers rapid access to various services like therapy, peer support, and primary care in a youth-friendly setting. Re…

This study was designed to test whether a program called Lifestyle MIND can help people with serious mental illness (like schizophrenia or bipolar disorder) prevent or manage type 2 diabetes. The program includes group exercise and health classes twice a week for 10 weeks. Howeve…

This study tests a telehealth system called Medherent for people with serious mental illness living in the community. The system dispenses medication, monitors health data like blood pressure and blood sugar, and allows virtual doctor visits. Researchers will track whether this a…

This study tests a program that offers homeless people with severe mental illness a place to stay and intensive community support instead of going through the criminal justice system. Researchers will compare how much time participants spend back in jail over 18 months versus tho…

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study compares a structured group exercise program called Braining with standard advice to exercise on your own. Over 12 weeks, 208 psychiatric patients will attend up to three clinician-led exercise sessions per week. Researchers will measure physical activity, depressive s…

This study explores whether eye-tracking technology in a virtual reality headset can help identify schizophrenia, bipolar disorder, and depression. Researchers will compare eye movement patterns of 120 participants (including healthy controls) to find specific markers for each co…

This trial tests a school-based program called HENKA, designed to promote emotional well-being and prevent mental health problems in adolescents aged 12 to 16. The program includes eight classroom sessions on skills like self-esteem, emotional regulation, and mindfulness, taught …

Researchers are testing whether ParentText, a WhatsApp-based parenting programme, can be delivered through government health services in South Africa's Western Cape. The programme has two five-lesson modules: one on improving caregiver-child relationships and one on keeping child…

Researchers are testing whether a detailed functional exam plus motivational interviewing helps physically inactive 40-year-olds become more active. Half of the 250 participants receive a full functional profile with advice and goal-setting support; the other half get standard me…

This trial tests whether 5-10 minutes of daily mindfulness and compassion training in school can prevent anxiety and depression in children aged 6-16. About 1,750 pupils will take part, with some classes doing the training for 10 weeks and others not. Researchers will track menta…

This study tests two counseling programs to help women who use drugs in Tanzania start and stay on PrEP, an HIV prevention pill. 200 women will be randomly assigned to receive either brief motivational counseling, the same plus extra mental health support, or standard information…

This study tests a program called BasketballRx, which combines basketball activities with lessons on healthy eating, exercise, sleep, and stress management. The program is designed for teens aged 10 to 15 who are overweight or have obesity, and who identify as Black or Latino. Ov…

This study looks at whether alerting clinical pharmacists about diabetes risk can help prevent type 2 diabetes in younger adults with serious mental illness. People with conditions like schizophrenia or bipolar disorder are at higher risk for diabetes, partly due to medication si…

The PANTHERS study tests a remote, home-based program called the Infant Behavior Program (IBP) to reduce behavior problems in infants aged 12-18 months from high-risk families. 288 families will receive either IBP or standard pediatric care, all conducted remotely. The goal is to…

This study tests a program called Healthy ReStart that uses health coaching, motivational interviewing, and online tools to help adults with serious mental illness return to active lives after major disruptions like the COVID-19 pandemic. Sixty participants will receive either th…

Researchers at Cambridge Health Alliance are adapting a mental health screening and support program for racially, ethnically, and linguistically diverse youth aged 12 to 17 in the Denver Health area. The program includes screening, feedback, a single session intervention, and res…

This study adapts Project YES+, a behavioral program, to improve mental health and reduce HIV-related stigma for adolescent and young men who have sex with men living with HIV in Vietnam. Eighty participants aged 16-24 will receive individual and group sessions with peer mentors.…

This study looks at whether a guided therapeutic writing program can help adult women with chronic pain and co-occurring mental health conditions. Participants will complete writing exercises focused on emotional processing and meaning-making over four weeks, then share their exp…

This pilot study tests whether a 4-week virtual mindfulness-based group intervention with social support is feasible and acceptable for pregnant individuals at higher risk for substance use. Participants join weekly video conference groups focused on grounding, thinking patterns,…

This study compares a 3-session couples program (Brief Relationship Checkup) to standard individual care for 360 veterans and their partners who have relationship and mental health concerns. The goal is to see which approach better reduces suicide risk factors by improving relati…

This study is testing the long-term safety of a drug called ML007C-MA for people with Alzheimer's disease who also have hallucinations and delusions. About 210 adults who completed a previous study will take the drug twice daily for up to 52 weeks. The goal is to see if the drug …

This study tests a drug called neflamapimod in 20 people with a language disorder called nonfluent variant primary progressive aphasia (nfvPPA). The goal is to see if the drug is safe and if it can improve language symptoms. Participants will receive either the drug or a placebo …

This study tests whether combining cognitive remediation training (a computer-based program to improve thinking skills) with mild brain stimulation (transcranial direct current stimulation) can help people with severe mental illness who live in supported housing. The goal is to i…

This study was designed to test whether a group therapy that uses basic communication skills common to all therapies can help people with depression, anxiety, PTSD, and stress. The therapy avoids specific methods like cognitive-behavioral therapy. The trial was withdrawn before a…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This study tests a program called I-CARE for teens aged 12-17 who are in a medical hospital waiting for mental health treatment after a suicide-related emergency. The program uses 7 short videos and workbook activities to help lower emotional distress and suicidal thoughts. Resea…

This study tests whether a diet rich in fermented foods (like yogurt and kimchi) is tolerable and can improve quality of life for survivors of critical illness, including severe COVID-19. The goal is to help restore gut health and reduce inflammation. The study involves 40 partic…

This study tests an experimental nasal spray called fasedienol for quickly reducing anxiety during a public speaking challenge in adults with social anxiety disorder. About 238 participants will receive either the spray or a placebo and rate their distress levels. The goal is to …

This pilot study tests whether an 8-week mindfulness program (MBSR) can reduce anxiety, depression, and stress in people with COPD who are already in pulmonary rehab. About 44 participants will be followed for 12 months. The goal is to see if this mind-body approach improves emot…

This pilot study is testing a type of talk therapy called Metacognitive Interpersonal Therapy (MIT-ED) for adults with various eating disorders, including those who are underweight. The therapy aims to help people understand and manage the negative thoughts and feelings that driv…

This pilot study tests a youth-adapted therapy called NECT-Y to see if it can reduce self-stigma in 96 young people with bipolar disorder or multiple mental health conditions. Participants will either join a 14-week virtual group therapy or continue their usual care. The main goa…

This study tests an online cognitive behavioral therapy (CBT) program for university students with mild depression or anxiety. Two hundred students who previously took a mental health survey will receive a tailored internet treatment. The goal is to see if this e-health approach …

This study aimed to see if trazodone works better than quetiapine or a placebo for treating confusion (delirium) in adult surgical ICU patients. It planned to measure how long delirium lasts, sleep quality, and side effects. However, the study was withdrawn before enrolling any p…

This study tests whether a smartphone app designed for people with serious mental illness can help them quit smoking. About 64 adults who smoke heavily and have a mental illness will use one of two special apps or a standard app for 5 weeks. All participants also get nicotine pat…

This study tests if a therapy called FIRST, which uses five key principles to help youth manage negative emotions, works better than standard therapy. About 212 youth aged 7 to 15 with anxiety, depression, trauma, or behavior problems will take part. The goal is to see if FIRST i…

This study looks at whether adding a structured therapy journal to standard cognitive behavioral therapy (CBT) helps people with mental health conditions like depression, anxiety, or eating disorders feel better faster. About 80 adults in outpatient therapy will be randomly assig…

This study tests a new app called Express Access that helps primary care doctors refer patients to mental health therapists. About 600 adults will use the app or standard referral methods. The goal is to see if the app leads to better well-being, higher satisfaction, and faster a…

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This study tests a 10-week peer support program (UPSIDES-Swe) for adults with serious mental illness in Sweden. Half of the 300 participants will get the program plus usual care, the other half usual care alone. Researchers will measure personal recovery, social inclusion, and qu…

This study looks at whether music therapy can lower anxiety and stress in people with severe mental illness who are staying in a hospital unit. Twelve participants will attend 15 one-hour music sessions where they choose songs and talk with a nurse. Researchers will measure chang…

This pilot study tests a tool called ED-TREAT that helps emergency room staff spot and treat agitation early. The goal is to see if the tool is easy to use and can reduce the need for physical restraints. The study involves 26 adults at Yale New Haven Hospital, but enrollment is …

This study tests whether psilocybin, the active ingredient in magic mushrooms, can safely help veterans with PTSD. Fifteen veterans will receive two doses of psilocybin in a supervised therapy setting. Researchers will monitor side effects and measure changes in PTSD symptoms.

This study tests whether a type of talk therapy called Cognitive Behavioral Therapy for Insomnia (CBT-I) can improve sleep and daily functioning in veterans who have both psychosis and insomnia. About 152 veterans are taking part. The goal is to see if better sleep leads to bette…

This study tests whether adding group mindfulness-based therapy to usual treatment helps people with serious mental illnesses like schizophrenia, bipolar disorder, or major depression. Researchers will randomly assign 160 patients to either usual care alone or usual care plus min…

This study tests a group therapy called Awareness, Courage, and Love (ACL) for older adults with psychiatric disorders who feel lonely. The therapy focuses on mindfulness, sharing feelings, and building connections. Researchers want to see if the program is practical and helpful …

This study tests whether a program combining motivational interviewing and mindfulness can help people who regain weight after bariatric surgery. About 52 adults who have regained at least 5% of their lowest weight after surgery will take part. The goal is to see if this approach…

This study tests whether a 28-week program of moderate-to-vigorous physical activity, including high-intensity interval training, can reduce disability and improve thinking in 100 adults with severe mental illness. Participants are outpatients living in the community. The program…

The SHAKTI study is a 5-year observational project that will follow 6,000 people of Asian or Pacific Islander descent, aged 10 and older, with depression or related mood disorders. Researchers will collect a wide range of data—including lifestyle, clinical history, blood and stoo…

This trial tests a home-based intervention called Khanya-Ekhaya, delivered by community health workers, to support the mental health of people living with HIV in South Africa. The intervention combines counseling techniques like motivational interviewing and problem-solving thera…

This study aims to find biological markers (biosignatures) in people with ALS and FTD to make diagnosis more precise. Researchers will analyze samples like spinal fluid, skin, and tears from 230 participants using advanced techniques. The goal is to create a 'disease fingerprint'…

This study surveys 1,500 former Norwegian elite athletes to map their mental and physical health after retirement. Researchers focus on differences between weight-sensitive sports, such as weight-class, aesthetic, and endurance sports, and less weight-sensitive ones. They will ex…

This study compares two versions of school-based mental health screening to see which helps more African-American elementary students get the mental health services they need. Researchers will track referrals and disciplinary incidents across many schools. The goal is to find bet…

This study follows about 2,200 mothers and their children in Cox's Bazar, Bangladesh, including Rohingya refugees and local families. Researchers want to understand how growing up in conflict and displacement affects child development and mental health. They are also looking at w…

This study looks at whether improving sleep can help overweight or obese African Americans who don't get enough exercise become more active. About 28 people will try a sleep program either before or after a physical activity program. The goal is to see if this approach is practic…

This study uses health records from about 100,000 people in Israel to see if past viral infections (like Epstein-Barr, COVID-19, or herpes) increase the risk of developing mental illnesses such as depression, anxiety, bipolar disorder, or schizophrenia. It also looks at whether i…

This study looks at whether an 8-week program of daily brain training exercises, combined with a gentle electrical current applied to the scalp (tDCS), can improve thinking, reduce falls, and help seniors with mental health conditions stay independent. About 270 older adults livi…

This study is creating a learning healthcare system for OnTrackNY, a program that helps young people (ages 16-30) who have recently experienced psychosis. Researchers will collect data and feedback from participants, families, and clinicians to continuously improve care. The goal…

This observational study surveys 150 adults with severe mental illness to learn how they use AI chatbots for mental health support. Participants answer a one-time anonymous online survey about their experiences, expectations, and concerns. The goal is to understand usage patterns…

This study tests a 10-week program called 'Grow to Recovery' for people with mental illness. The program is co-led by a peer (someone who also has a mental illness) and a professional. Researchers want to see if it helps participants feel more hopeful and capable. 138 people are …

This study looks at how to best help people with serious mental illness take part in a program that lowers heart disease risk. Researchers will test different support strategies at community mental health clinics in Michigan and Maryland. The goal is to find the most effective wa…

This study tests whether an early assessment of activity limitations by occupational therapists can help people with mental disorders return to work. 150 participants in specialized psychiatric care will either receive the assessment or usual care. The goal is to see if this lead…

This study tests a program called 'Enhancing Your Immune Health' for adults with serious mental illness. The program teaches about immune health and how to manage it. Researchers will see if participants report better immune status and feel more confident managing their health.

This study explores how to add a mental health program called Mothers and Babies into existing home visiting services for pregnant people and new parents in Iowa and Indiana. Researchers will work with 1,750 home visitors and program recipients to see how well the program is adop…

This study explores how non-invasive brain stimulation can help understand and treat agitation in people with Alzheimer's and mixed dementia. Researchers will use transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to study brain activity, and test whether tr…

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This study tests whether a 12-week program that combines brain training, social activities, and exercise is practical and liked by seniors with mental health conditions living in community housing. About 18 participants will try the program in small groups, guided by a support wo…

This study is developing and testing a smartphone app called R-Assist for people recently released from jail who have both substance use and mental health disorders. The app tracks symptoms, connects users to resources like housing and recovery groups, and measures how easy it is…

This study reviews the medical records of 1,200 people who sought treatment for gambling disorder in Sweden over 10 years. Researchers will track changes in gambling habits, physical and mental health conditions, and use of healthcare services. The goal is to better understand th…

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This study involves 40 healthy volunteers aged 18 to 86 who will undergo MRI brain scans and transcranial magnetic stimulation (TMS). The goal is to collect reference data to recalibrate the hospital's MRI scanner after an upgrade. No treatment or drug is being tested; the result…

This study aims to understand how the brain's pain-processing systems relate to a person's ability to attempt suicide. Researchers will use fMRI scans to measure brain activity in 90 adults with depression while they experience pressure pain. The goal is to identify neural patter…

This study aimed to track brain activity in people with depression over time and see how a single dose of ketamine might change it. It was withdrawn before any participants were enrolled, so no results are available.

This study looks at how chemicals and social factors before birth may affect brain function and mental health in teenagers. Researchers will use brain scans and behavior questionnaires in 250 adolescents aged 13-20. The goal is to understand pathways linking early exposures to ps…

This study was designed to see if low-intensity focused ultrasound could safely change brain activity related to emotion and thinking. It planned to test the device on healthy volunteers using brain scans. However, the study was withdrawn before enrolling any participants, so no …

This study compares standard mental health care to an early assessment team for 588 adults referred to outpatient clinics. The goal is to see if early, personalized evaluation improves daily function, mental health, and quality of life. Participants are randomly assigned to eithe…

This study tests a method called SAIA-MH to help clinics in Mozambique better diagnose, treat, and follow up with people who have mental health conditions. Researchers will compare clinics using this approach to those that don't, involving about 155 patients. The goal is to see i…

This study looks at brain tissue and lab-grown nerve cells from people with schizophrenia, depression, bipolar disorder, frontotemporal dementia, and Alzheimer's. Researchers want to find out how problems with synapses—the connections between brain cells—differ in these condition…

This study follows 136 children from Romania who were placed in foster care after living in institutions. Researchers track their thinking skills, emotional health, brain activity, and social behavior into young adulthood. The goal is to understand whether early foster care can i…

This study was designed to track stress in real time by measuring things like heart rate, sweat, and temperature, along with how people feel. It planned to include both healthy volunteers and people with psychiatric disorders to find better ways to diagnose stress-related problem…

This study follows 192 teens aged 12 to 20 who are already receiving either Cognitive Behavioral Therapy (CBT) or Brief Strategic Therapy (BST) for anxiety, depression, or OCD. Researchers will track their progress using questionnaires and interviews over 9 months. The goal is to…

This pilot study looks at whether a computer-based alcohol intervention, combined with help from a community health worker, can reduce heavy drinking and improve HIV prevention among women. About 12 women who drink heavily and are either living with HIV or at risk for it will tak…

This study follows 120 people in group therapy for alcohol use disorder to see which patient factors—like mental health, drinking severity, personality, or thinking skills—predict who finishes treatment and stays sober a year later. Researchers hope to learn how to match patients…