Lung cancer

Researchers are testing whether a doctor can remotely steer a robotic bronchoscope over a 5G network to freeze small lung tumors from inside the airway. The study enrolls about 15 adults with non-small cell lung cancer or controlled metastatic lung tumors, each no larger than 3 c…

Researchers are testing whether giving targeted therapy before and after surgery helps people with stage III non-small cell lung cancer that has specific rare gene changes. The study includes 190 adults whose tumors have alterations in genes like EGFR, ALK, ROS1, MET, RET, or KRA…

Researchers are testing whether a shared checklist used during lung cancer surgery helps surgeons achieve cleaner, more complete tumor removal. The trial enrolls adults with early-stage non-small cell lung cancer who are scheduled for surgery. Half the participating hospitals use…

This trial tests a device that uses pulsed electric fields to destroy lung tumors. It is for people with early-stage non-small cell lung cancer or lung metastases that cannot be removed with surgery or treated with radiotherapy. Participants receive the ablation under general ane…

People newly diagnosed with breast, colorectal, lung, or prostate cancer often also manage other long-term conditions and take multiple medications. This pilot study tests whether a pharmacist-led medication review plus the Medisafe mobile app helps them stick to those regimens. …

This phase 2 trial tests whether zipalertinib, an oral drug that targets cancer cells with atypical EGFR mutations, can eliminate remaining cancer cells in people with early-stage non-small cell lung cancer. Participants who have completed standard treatment and show signs of min…

This trial tests whether a coordinated care pathway, involving oncologists, geriatricians, pharmacists, and pharmacologists, can reduce severe side effects in adults over 70 with certain cancers who are starting oral therapy. Participants receive extra monitoring, including blood…

This trial tests a cell therapy called DC-CTL, made from a patient's own immune cells, combined with standard anti-tumor treatment. The goal is to see if this approach is safe and may help control solid tumors such as colorectal, esophageal, lung, liver, and breast cancer. About …

This study tests whether adding a cancer vaccine (CIMAVAX-EGF) to standard targeted drugs (sotorasib or adagrasib) can help control advanced lung cancer with a KRAS G12C mutation. About 29 adults with stage III or IV non-small cell lung cancer will receive the combination. The go…

This trial tests a type of radiation called brain-avoidant proton craniospinal irradiation (BRAVO-pCSI) in people with leptomeningeal metastases, a condition where cancer spreads to the fluid and lining around the brain and spinal cord. The study includes adults with breast cance…

This trial tests a new approach to pulmonary rehabilitation, a standard programme of exercise and education for people with chronic lung disease. The twist is that informal carers, often family members, join the education and support sessions. The goal is to see if this carer-inc…

This trial tests whether a ventilation strategy based on mechanical power—a measure of energy delivered to the lungs—can reduce postoperative pulmonary complications like pneumonia and collapsed lungs in adults undergoing lung resection surgery. Participants are randomly assigned…

This trial investigates whether specially engineered T cells can safely target and fight lung cancer. Participants have advanced or relapsed lung cancer and receive a single infusion of their own T cells that have been trained to recognize cancer-specific markers. The study aims …

This trial tests whether tirzepatide, a medication used for weight management, can reduce the rapid weight gain and metabolic changes caused by lorlatinib, a targeted therapy for ALK-positive non-small cell lung cancer. Adults already taking lorlatinib will receive weekly tirzepa…

This study tests whether giving a dye called Cytalux a few days before surgery works as well as giving it closer to the operation. The dye makes tumors glow under a special light, helping surgeons remove them more completely. About 106 adults with suspected lung cancer or confirm…

This trial tests whether combining an EGFR-targeted pill (EGFR-TKI) with an antibody-drug conjugate (trastuzumab rezetecan) can shrink tumors in people with advanced non-small cell lung cancer that has both an EGFR mutation and HER2 alterations. Participants receive the combinati…

This trial tests whether MRI-guided stereotactic body radiotherapy (SBRT) can safely treat ultra-central lung tumors—growths located near the windpipe and major airways. Using an MR-LINAC machine, doctors can adjust the radiation beam in real time as the patient breathes, potenti…

This early-phase trial is testing an experimental antibody-drug conjugate called MC002 in adults with advanced solid tumors, such as esophageal or lung cancer, that have progressed after standard treatments. MC002 is designed to target a protein found on cancer cells and deliver …

This trial compares two treatments for early-stage lung cancer in patients who cannot have surgery: microwave ablation delivered through a bronchoscope versus standard stereotactic body radiotherapy. The goal is to see which approach better controls the tumor over two years, with…

This study is for people with a specific type of lung cancer (EGFR-positive adenocarcinoma) that has spread to the lining of the chest, causing fluid buildup. Researchers are testing whether combining a daily targeted pill (furmonertinib) with focused chest radiation can safely c…

This phase II trial tests the drug cemiplimab, an immunotherapy, given before and after surgery for people with early-stage non-small cell lung cancer that has high levels of a protein called PD-L1. About 33 participants will receive cemiplimab for three cycles, then undergo surg…

This early-stage trial tests a new cell therapy called GK01 for people with advanced lung cancer who have not responded to standard treatments. The therapy uses a patient's own immune cells (T cells) that are specially prepared to attack the cancer. The main goal is to check safe…

This early-phase study tests an inhaled mRNA immunotherapy for adults with advanced lung cancer or solid tumors that have spread to the lungs. The treatment is given as a dry powder through an inhaler. The main goal is to check safety and find the best dose, with 60 participants …

This study tests a combination of two drugs, QL1706 and anlotinib, for people with advanced small cell lung cancer who have already tried at least two prior treatments. The goal is to see if the combination helps control the cancer and extends survival. About 120 adults aged 18 t…

This study tests a new approach for lung cancer patients who are at high risk of incomplete tumor freezing during cryoablation. Before the freezing procedure, doctors will block small blood vessels near the tumor using a temporary, absorbable material. The goal is to make the fre…

This early-stage study tests a new treatment called DCTY1102 for people with advanced cancers (like pancreatic, colorectal, or lung cancer) that have a specific genetic change (KRAS/NRAS G12D mutation) and a certain immune type (HLA-A*11:01). The treatment uses the patient's own …

This early-stage trial tests a new drug called CRPA1A2, which helps the body's immune cells attack cancer cells. It is for people with certain advanced solid tumors (like lung, esophagus, head and neck, or liver cancer) that have not responded to other treatments. The study will …

This study tests whether adding radiation to immunotherapy and chemotherapy can help people with advanced small-cell lung cancer that has spread to the liver. It includes 30 adults aged 18-75 whose cancer did not respond to or stopped responding to prior treatments. The goal is t…

This study tests whether a special omega-3-enriched nutritional drink can improve nutrition in people with advanced lung or colorectal cancer who are at risk of malnutrition. About 118 participants will either get the drink plus dietary advice, or just dietary advice alone. The g…

This early study tests a robotic bronchoscopy system that aims to detect, sample, and treat small lung tumors in a single procedure. About 30 adults with suspicious lung nodules up to 3 cm who cannot or choose not to have surgery will participate. The system uses advanced imaging…

This early-stage trial tests injecting the chemotherapy drug cisplatin directly into lung tumors using a thin tube with a camera. The goal is to see if this approach is safe and can kill more cancer cells while causing fewer side effects than standard IV chemo. The study will enr…

This study tests whether adding capivasertib to osimertinib can help people with a specific type of advanced lung cancer whose disease has worsened after initial treatment. About 53 adults with EGFR-mutant NSCLC and additional PIK3CA/AKT1/PTEN gene changes will receive the two dr…

This phase 2 trial tests a sequence of targeted therapy (garsorasib), immunotherapy (ivonescimab), and chemotherapy before and after surgery for people with a specific type of lung cancer (KRAS G12C mutation) that can be removed. The goal is to see if this approach increases the …

This Phase 2 trial tests a combination of two drugs, tunlametinib and cetuximab β, in 55 people with advanced non-small cell lung cancer that has a KRAS mutation and has not responded to prior treatments. The goal is to see if the combo can shrink tumors and control the disease. …

This study compares two types of targeted therapy (first-generation vs third-generation EGFR TKIs) for people with advanced lung cancer that has a specific rare mutation called EGFR exon 19 deletion-insertion. About 94 participants will be randomly assigned to one of the two trea…

This study compares two treatments for high-risk patients with early-stage non-small cell lung cancer: minimally invasive surgery (wedge resection) and stereotactic body radiation therapy (SBRT). The goal is to see which approach leads to longer disease-free survival and better q…

This early-stage trial is testing a new oral drug called HS-10504 combined with several other drugs given by IV in people with advanced non-small cell lung cancer that has worsened after previous treatment. The study will enroll about 400 participants and aims to find safe doses …

This study is testing a device called the HybridTherm® system, which uses freezing and radiofrequency heat to destroy small lung tumors during a routine bronchoscopy. The procedure is done before the patient's planned surgery to remove the tumor. The main goals are to see if the …

This study tests two drugs, sacituzumab govitecan and ivonescimab, alone or together, in people with advanced non-small cell lung cancer that has specific gene changes. The goal is to see if the combination works better than either drug alone at shrinking tumors and delaying canc…

This study compares two ways of performing robotic lung surgery for early-stage non-small cell lung cancer. In one method, the surgeon controls all tools from a console (totally robotic). In the other, a bedside assistant helps with handheld staplers. The trial will measure costs…

This study tests a combination of anlotinib pills and standard chemotherapy for people with a rare, advanced lung cancer that lacks the SMARCA4 gene. About 28 adults will receive the treatment in 21-day cycles to see how long it keeps the cancer from growing and what side effects…

This phase 2 trial tests the drug golidocitinib in 16 people with advanced lung cancer who have severe blood problems caused by immunotherapy. The goal is to see if the drug can safely improve blood counts and reduce symptoms. Participants take the drug until their blood levels r…

This study looks at whether adding an SGLT2 inhibitor (a type of diabetes pill) to standard cancer treatment can help people with advanced lung cancer and diabetes live longer or slow their tumor growth. About 200 adults will take either the SGLT2 inhibitor or other diabetes drug…

This study tests a therapy that takes a patient's own immune cells, grows and strengthens them in a lab, and then gives them back to fight cancer. It is for people with advanced lung, liver, colorectal, or breast cancer that has spread. The goal is to see if this approach is safe…

This study looks at whether a drug called sacubitril/valsartan, already used for heart failure and high blood pressure, can help people with advanced lung cancer who also have high blood pressure. The goal is to see if it reduces the risk of death and heart problems. About 200 ad…

This phase 2 trial tests a combination of two drugs—sacituzumab tirumotecan and bevacizumab—in 31 adults with advanced non-squamous lung cancer that has worsened after initial treatment. The goal is to see if the combo can shrink tumors or slow the disease. Participants receive t…

This study looks back at medical records of 600 Chinese patients with advanced non-small cell lung cancer that has a KRAS G12C mutation. All patients took the drug IBI351 between August 2024 and August 2025. Researchers will check how many patients' tumors shrank or disappeared, …

This phase 2 trial tests a combination of two drugs, Sacituzumab tirumotecan and bevacizumab, in 50 people with a specific type of lung cancer (EGFR-mutant nonsquamous NSCLC) that has spread to the brain and no longer responds to standard targeted therapy. The goal is to see if t…

This study tests a robotic bronchoscope to inject a dye near small lung nodules before they are removed surgically. The dye helps surgeons see the nodule during operation, making removal more accurate. Fifty patients with hard-to-find nodules will be enrolled, and researchers wil…

Researchers are building an artificial intelligence system that analyzes chest CT images and offers decision support to doctors reading those scans for lung cancer. They use deidentified CT exams from routine care to develop and lock the AI models. In the prospective stage, about…

Radiation pneumonitis is a lung inflammation that can appear weeks after radiotherapy for lung cancer, and patients may not link their symptoms to the earlier treatment. Researchers developed a smartphone app called PneumoCheck for patients to use at home, hoping it helps detect …

Researchers at Penn State University are testing three software innovations designed to improve bronchoscopy guidance during lung cancer evaluations. The study enrolls a small number of adults who are already scheduled for a clinical bronchoscopy to examine abnormal lung tissue o…

Researchers are testing whether an electronic nose that analyzes exhaled breath can serve as a noninvasive prescreening tool for several diseases at once. The study plans to enroll up to 20,000 adults and will first standardize the breath-sampling procedure, then evaluate how wel…

This trial tests whether a new imaging method, using femtosecond laser light and artificial intelligence, can accurately predict high-risk features in lung cancer, such as spread to lymph nodes. Researchers will compare the AI's predictions with actual pathology results from surg…

This trial tests whether adding a small probe called the Iriscope to standard bronchoscopy improves the diagnosis of lung nodules. Doctors usually guide the biopsy with real-time X-rays, but sometimes they cannot see the nodule directly. The Iriscope slides into the bronchoscope …

This trial tests whether a femtosecond laser imaging technique, combined with artificial intelligence, can accurately distinguish benign from malignant lung tissue in surgical specimens. Researchers will compare the AI-assisted diagnosis against standard pathology results. The st…

This trial is testing two new imaging tracers, called CM500, to see if they can help detect solid tumors anywhere in the body. The tracers are given by injection and then used with PET scans to create detailed images. The study includes healthy volunteers and people with various …

This pilot study will offer low-dose CT scans to about 500 high-risk smokers aged 50-80 in Kuwait to see if this screening approach is practical and acceptable. The goal is to measure how many people agree to screening, identify barriers, and evaluate the use of AI to help read t…

This trial is testing whether a breath analysis device can detect unique chemical patterns—called volatile organic compounds—that may signal the presence of cancer. Researchers will collect breath samples from 1,000 people with various cancers and 1,000 healthy volunteers, then u…

This pilot study explores whether a breath sample collected with the VosCryo device can provide enough cellular material to help diagnose advanced lung cancer. Researchers will compare breath samples from 12 people with late-stage lung cancer and 12 healthy relatives to see if th…

This study tests an artificial intelligence (AI) prototype designed to quickly evaluate tissue samples taken during a bronchoscopy, a procedure used to diagnose lung cancer. The AI analyzes microscope images of the samples to determine if they are adequate for diagnosis and wheth…

This study is testing whether a blood test that looks for genetic changes (ctDNA) can help detect lung cancer early in people who have suspicious lung nodules found on CT scans. Researchers will collect blood samples from 200 participants in Hong Kong and Vietnam at the start and…

This study tests a new radioactive tracer called 68Ga-MY for PET scans. It targets a protein (5T4) found on many cancer cells but rarely on healthy cells. About 20 people with lung or breast cancer will get both a standard FDG scan and a 68Ga-MY scan. Researchers will compare the…

This study will check if low-dose CT scans can find lung cancer early in 1,716 high-risk smokers in India. Participants get a baseline scan, and if anything looks suspicious, they are referred to a team of specialists for follow-up. The goal is to see if this screening method wor…

This study will test a new, disposable freezing catheter (Celsio) in 30 people who need a lung procedure. The catheter uses extreme cold to help diagnose or treat conditions like lung cancer and interstitial lung disease. Unlike current devices, it does not need a bulky console o…

This study tests whether a new MRI contrast agent, gadopiclenol, can detect brain metastases earlier than standard methods in 180 patients with advanced lung, breast, or skin cancer. Participants will receive screening brain MRIs to compare diagnosis timing and accuracy. The goal…

This study will test whether low-dose CT scans can help find lung cancer early in high-risk smokers aged 50-79 in Hong Kong. About 15,000 participants will be randomly assigned to receive three rounds of CT scans or usual care. The main goal is to see if screening reduces lung ca…

This study tests a new PET imaging agent, 68Ga-cPP-BCH, to detect PD-L1 protein levels in tumors of people with lung cancer, melanoma, or other solid tumors. The goal is to see if this scan can identify who might benefit from anti-PD-1/PD-L1 immunotherapy without needing a tissue…

This study looks at whether low-dose CT scans can help find lung cancer early in people aged 40 to 80 who have never smoked. About 2,500 participants will fill out questionnaires, give blood and urine samples, and have lung function tests and CT scans. Researchers will track how …

This study will test whether a new type of PET scan (18F-FAPI) can more accurately detect lung cancer and help predict patient outcomes. About 120 adults already diagnosed with lung cancer will receive the scan. The goal is to see if this imaging method is better than current tec…

This study aims to see if a blood test, taken before lung cancer surgery, can predict which patients will develop serious lung complications afterward. Researchers will analyze immune cells and proteins in the blood of 100 adults undergoing lung surgery. If the test works, it cou…

This study tests if using a confocal laser microscope along with a freezing probe (cryoprobe) makes lung biopsies safer and more accurate. Forty adults with lung spots will be split into two groups: one gets the standard ultrasound-guided biopsy, the other gets the new laser-guid…

This study tests whether artificial intelligence (AI) software can help radiologists find lung cancer on low-dose CT scans more accurately. About 1,120 adults at risk for lung cancer will be randomly assigned to have their scans read with or without AI assistance. The goal is to …

This study compares a new robot-assisted system to the standard manual method for taking a tissue sample (biopsy) from a lung nodule. The goal is to see if the robot is as safe and effective at diagnosing lung cancer or other conditions. About 158 adults with suspicious lung nodu…

This study compares 3D models from non-contrast CT scans to standard contrast CT scans for planning minimally invasive lung cancer surgery. Researchers will check if the 3D models accurately show blood vessels, airways, and tumor location during surgery. If they work, patients mi…

This study will test whether a special CT scan (dual-energy CT) can be as good as MRI for mapping tumors and healthy organs before radiation therapy. Researchers will enroll 80 people with brain, bone, head/neck, or lung cancer. If DECT works well, it could save time and money co…

This trial tests whether a community-based program called Witness Project Lung can increase lung cancer screening among Black adults aged 50 to 80 who smoke or quit within the past 15 years. The program uses peer role models, videos, and tailored materials to educate participants…

This study tests a vaccine called SurVaxM in 80 current or former heavy smokers at high risk for lung cancer. The vaccine trains the immune system to recognize and attack cells that produce a protein called survivin, which is common in cancer cells. The goal is to see if the vacc…

This study tests whether home-based breathing exercises and stationary bike workouts can improve lung health in 200 current and former smokers aged 50 and older. Participants will use a handheld breathing device and a stationary bike for 12 weeks. The goal is to see if these exer…

This study compares two ways to share lung cancer screening information with people who call tobacco quitlines. Participants are quitline clients aged 50 to 80 with a heavy smoking history. One approach offers extra coaching and navigation support. The goal is to see which method…

This study aims to find the best ways to increase lung cancer screening among current and former smokers aged 50-80 in community health centers. About 19,000 participants will receive text messages and clinic support to complete eligibility checks and low-dose CT scans. The goal …

This study looks at whether the shingles vaccine can prevent shingles and improve survival in 500 lung cancer patients. Participants will either receive the vaccine or not, and researchers will track shingles cases and survival rates over time. The goal is to see if the vaccine o…

This study tests whether the blood thinner apixaban can prevent dangerous blood clots in people with lung cancer who are receiving chemotherapy or similar treatments. About 1,456 participants will take either apixaban or a placebo twice a day for six months. The goal is to see if…

This trial tests whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve sleep quality in adults undergoing surgery for lung cancer. Participants with poor sleep before surgery will receive either active rTMS or a sham (inactive) treatment over five …

This study aims to create a brief behavioral intervention for older adults (60+) with lung cancer, addressing aging-specific concerns like depression, anxiety, pain, and shortness of breath. In the first phase, patients, caregivers, and providers give feedback on the program. In …

This study tests if giving a long-lasting numbing medicine in two different places around the ribs and chest wall can reduce pain and the need for strong painkillers after robotic lung surgery. About 300 adults having this surgery will be randomly assigned to receive the numbing …

This trial tests whether adding mindfulness training to a standard respiratory symptom management program can reduce anxiety and ease breathlessness, cough, and fatigue in people with lung cancer. About 189 patients will be randomly assigned to one of three groups: the combined m…

This randomized trial tests whether immersive virtual reality (VR) can reduce anxiety in people with lung cancer during immunotherapy or chemo-immunotherapy infusions. Half of the 60 participants will use a VR headset showing calming nature scenes during four infusion visits, whi…

Shortness of breath, or dyspnea, affects most lung cancer patients and often persists despite standard treatments. This pilot study tests a stepped-care behavioral intervention called INSPIRE, which starts with brief coping skills and adds more intensive psychological support onl…

This trial tests whether a digital platform that sends symptom check-ins and self-care tips via text message can help people with head and neck or lung cancer report their health more consistently. Participants either receive standard symptom questionnaires or get extra monitorin…

This study tests whether giving a nerve block at two rib levels instead of one can better control pain after video-assisted thoracoscopic surgery for lung cancer. Eighty-eight adults scheduled for lung surgery will receive either a standard single-point block or a two-point block…

This study tests a short behavioral program called BREEZE+ to help people with advanced lung cancer manage breathlessness. The program includes three nurse-led sessions and a digital app that teaches breathing and relaxation skills. Researchers will compare this to usual care in …

This trial compares standard radiation therapy with a new method that specifically avoids damaging small airways in the lungs. The goal is to see if this airway-sparing approach helps patients with stage III non-small cell lung cancer retain better breathing function after treatm…

This study tests a home-based app for lung cancer patients on combination drug therapy. The app helps patients track symptoms, get personalized advice, and receive nurse support during treatment breaks. Researchers will see if it reduces symptom burden and improves quality of lif…

This study tests whether a smartphone reminder app can help lung cancer patients stay physically active during radiation therapy. About 32 adults with lung cancer will use the app or standard care, and their daily step counts will be compared. The goal is to see if simple digital…

This study tests whether a 12-week exercise program, delivered via Zoom, is practical and helpful for older adults (65+) with cancer who live in rural areas. Participants will do two supervised exercise sessions per week. The goal is to see if the program improves quality of life…

This study tests whether a home-based exercise program can help people with gastrointestinal or lung cancer handle chemotherapy better. Up to 120 participants will be randomly assigned to either an aerobic and resistance exercise group or a stretching group. All activities are do…

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplantation) can help advanced cancer patients who are losing weight and appetite—a condition called cachexia. About 66 adults with stomach, colorectal, or lung cancer will receive the treatment. Th…

This study will test whether mindfulness-based breathing exercises can help lung cancer patients who are undergoing chemotherapy feel less breathless and improve their quality of life. Sixty patients will be split into two groups: one will practice these breathing exercises for e…

This study tests whether a supervised exercise program, started two weeks before chemotherapy and continued for 16 weeks during treatment, can help adults aged 35 to 65 with breast, lung, or colon cancer tolerate chemotherapy better. The goal is to see if participants can receive…

This study tests whether doing special breathing exercises for a few weeks before lung cancer surgery can reduce problems like pneumonia and help patients leave the hospital sooner. 70 people scheduled for lung cancer surgery will be randomly assigned to standard care or standard…

This study tests a home-based program of exercise and breathing techniques for people with lung cancer who are scheduled for surgery. The program lasts 8 weeks before surgery and 4 weeks after, using a smartphone app to guide patients. Researchers want to see if it improves fitne…

This study tests a special breathing tube with a built-in camera for people undergoing repeat lung surgery. The tube helps doctors see exactly where it is placed, which may reduce problems like mispositioning. The trial will compare this video tube to the standard tube in 500 pat…

This study tests whether a combination of two anti-nausea drugs (rolapitant and palonosetron) can prevent vomiting and severe nausea in 238 lung cancer patients receiving both chemotherapy and radiation. The goal is to improve comfort during treatment. Participants will be follow…

This study compares a 'tubeless' approach to standard care for people having minimally invasive surgery to remove small lung nodules. The tubeless group gets a laryngeal mask instead of a breathing tube and no chest drain after surgery. The goal is to see if they recover better w…

This study tests whether Huaier Granules, a traditional Chinese medicine, can reduce proteinuria (excess protein in urine) caused by the cancer drugs bevacizumab or anlotinib in lung cancer patients. About 40 adults will be enrolled and followed for 16 weeks to see if the granule…

This study tests whether using a lung perfusion PET/CT scan to guide radiation planning can reduce lung injury compared to standard anatomical planning. About 418 adults with lung tumors receiving stereotactic body radiotherapy (SBRT) will be randomly assigned to one of the two p…

This study tests whether listening to a hypnotic audio recording during a 4D CT scan can reduce image artifacts (blurring or distortions) for 25 adults receiving lung cancer radiation therapy. Participants will have scans with and without the recording to compare quality. The goa…

This early-phase study tests whether adding malic acid (a natural fruit acid) to standard immunotherapy is safe for people with solid tumors like colorectal, lung, or melanoma cancer. About 30 participants will take malic acid by mouth while continuing their immunotherapy. The ma…

This study tests whether gentle, hands-on osteopathic techniques can stimulate the vagus nerve in people with advanced lung cancer. Researchers will measure heart rate variability, a sign of nerve health, and check if these safe, non-invasive treatments reduce anxiety during chem…

This study looks at whether Benson relaxation exercises can improve sleep quality in people with lung cancer who are staying in the hospital. About 60 patients will be randomly assigned to do the exercises or not. The goal is to see if this simple, drug-free technique helps them …

This study compares different anesthesia methods to see if they can prevent chronic cough after video-assisted lung surgery. 228 lung cancer patients will be randomly assigned to different airway management strategies during surgery. Researchers will track cough severity, duratio…

This study will screen 477 current or former smokers in Brazil for lung cancer using CT scans. It aims to see how often the scans give false alarms (false positives) in a region where lung infections are common. The goal is to improve screening accuracy and reduce unnecessary fol…

Researchers are testing an experimental cryoablation catheter that freezes lung tissue, using donated human lungs kept alive outside the body. The goal is to see whether the device can reach and cool tumors through the airways, which could offer a less invasive option than surger…

Some people who have keyhole lung cancer surgery develop lasting breathlessness and struggle with gentle exercise, even if their breathing was fine before. Researchers suspect the right side of the heart, which pumps blood to the lungs, may be weakened by the extra pressure it fa…

This study will enroll 1,500 current or former smokers aged 50-80 to see if an artificial intelligence (AI) model can help doctors better detect lung nodules and predict cancer spread. Participants will undergo CT scans, and the AI's results will be compared to standard radiologi…

Researchers are collecting blood and tumor tissue samples from 30 adults with relapsed small-cell lung cancer who are receiving a standard DLL3 T cell engager therapy. The goal is to track changes in tumor markers over time and see if those changes relate to how well the treatmen…

This study uses a special PET scan to track a tracer called 89Zr-trastuzumab in people with advanced lung cancer that has HER2 changes. The goal is to see if the tracer builds up differently in tumors with HER2 mutations versus those with too much HER2 protein. About 20 adults wi…

This study is looking at whether analyzing blood, urine, and stool samples can help predict which lung cancer patients are more likely to develop radiation pneumonitis—a type of lung inflammation—after receiving immunotherapy and radiation therapy. The researchers will collect sa…

This study aims to better understand tuberculosis (TB) across its entire spectrum—from early, symptom-free infection to active disease and after treatment. Researchers will recruit TB patients and their close contacts to analyze immune responses and identify biomarkers that could…

This trial tests a new communication workflow called CORRECT that helps radiologists and radiation oncologists work together more effectively when planning radiation therapy for lung and head-and-neck cancers. About 194 patients will be involved, and doctors will use a shared sys…

This study looks at how certain cancers develop in people with HIV and what factors might increase their risk. Researchers will analyze medical data from 1,000 HIV-positive adults to track which types of cancer occur most often and why. The goal is to improve early detection and …

This study is testing whether a blood test can locate where colorectal cancer has returned or spread after surgery. Researchers are analyzing genetic markers in the blood to build a model that predicts whether a recurrence is local or distant. The goal is to improve early detecti…

This study will enroll over 3,200 adults in Delhi and surrounding areas to understand how air pollution, especially fine particles (PM2.5), combines with other factors like smoking and genetics to increase lung cancer risk. Researchers will also look for biomarkers and identify g…

This study looks at two different methods doctors use to re-inflate a lung after it has been collapsed during surgery. About 350 people having lung surgery will take part. The goal is to see which method leads to fewer lung problems like pneumonia or collapsed air sacs in the wee…

This study looks at medical records of 3,000 adults with lung cancer to see if the stage at diagnosis is shifting to earlier, more curable stages. Researchers will track how often cancer is found through screening programs, chest X-rays, or heart scans. No new treatments or tests…

This study compares a new electromagnetic navigation system to standard CT scans for guiding surgeons to small lung nodules during surgery. About 400 adults with nodules up to 2 cm will be randomly assigned to one method. The goal is to see which approach helps surgeons find and …

This study tests whether a new real-time imaging method can make radiation therapy more accurate for cancer patients. About 40 adults with various cancers will receive their normal radiation treatment while the new imaging tracks the tumor in real time. The goal is to see if the …

This study will look back at medical records of 300 people with advanced non-small cell lung cancer (NSCLC) whose disease got worse after first-line immunotherapy. Researchers want to see which second-line treatments were used and how well they worked in real-world practice. The …

This study looks at whether people with peripheral vascular disease (narrowed leg arteries) might also be at high risk for lung cancer because of shared smoking history. Researchers will check if these patients qualify for lung cancer screening and refer them for a low-dose CT sc…

This study looks at how adults with lung nodules that might be cancer make decisions about their care before a final diagnosis. Researchers will use questionnaires to measure patients' confidence, doubts, and satisfaction with their choices. The goal is to find out what factors h…

This observational study will enroll 300 people with suspected lung lesions to see if 3D ultrasound can measure them as accurately as CT scans. Participants will undergo both ultrasound and CT imaging, and researchers will compare the results. If the 3D ultrasound works well, it …

This study looks at how different surgical tools used during lung cancer surgery might affect coughing after the operation. About 248 adults having right lung surgery will be randomly assigned to one of two tool types. The goal is to find out which tool causes less nerve damage a…

This early-stage study looks at how the drug anecatibin fumarate is processed in the body of people with and without liver problems. It will include 24 adults with lung cancer. The goal is to understand safety and drug levels, not to test if the drug works.

This study will expose 24 healthy adults to different levels of wildfire smoke in a safe, controlled room to see how it affects their lungs and brain. Researchers want to understand why some people may be more vulnerable to long-term lung diseases like asthma, COPD, and lung canc…

This pilot study will check if tumor DNA in spinal fluid can predict brain metastases in 40 patients with stage III or IV non-small cell lung cancer. Participants will undergo a lumbar puncture to collect cerebrospinal fluid, plus blood draws and an MRI six months later. The goal…

This study will test if a simple, low-intensity cycling exercise combined with a handheld monitor can predict serious complications in lung cancer patients before surgery or other treatments. Researchers will include 500 adults with suspected lung cancer. The goal is to make risk…

This study looks at sputum and blood samples from 50 adults with advanced non-small cell lung cancer who are starting immunotherapy. Researchers want to find immune cell changes that could predict which patients will respond well to treatment. The goal is to better understand the…

This study looks at whether an extra cleaning step during a common lung cancer staging procedure (EBUS) can reduce contamination of tissue samples. Researchers will collect samples from 204 adults with suspected lung cancer. The goal is to see if better cleaning leads to more acc…

This study will interview 120 cancer patients in Texas to learn what makes it easier or harder to get timely cancer treatment. Researchers will talk with patients by phone or video to understand their experiences across different cancer types and insurance plans. The goal is to i…

This study will enroll 63 people with advanced non-small cell lung cancer whose disease has been stable for at least 6 months. Participants will take part in a 3-month rehabilitation program that includes physical activity. Researchers will measure quality of life, hand grip stre…

This study looks at how cancer and its treatments change the way people experience food, including taste, mouth health, and overall eating pleasure. Researchers will ask 180 adults with different cancers to fill out a detailed questionnaire about their eating habits and feelings.…

This study tests whether extended reality (XR) can help doctors more accurately locate small lung nodules during CT scans. About 30 adults scheduled for lung nodule surgery will participate. The goal is to see if XR guidance improves precision and reduces complications.

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This large observational study will enroll 14,300 people aged 40-74 to see if combining a non-contrast CT scan with a blood test that looks for DNA changes can detect lung cancer earlier. The goal is to develop a more accurate screening method. Participants must have a lung cance…

This study uses artificial intelligence to analyze CT scans, pathology slides, and genetic reports from 1,000 lung cancer patients with EGFR mutations. The goal is to build a model that predicts how well targeted therapy will work after surgery. If successful, it could help docto…

This study looks at how a personalized strength training program affects people with different cancers, including lung, colon, breast, and blood cancers. 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers …

This study will analyze genetic data from 100,000 people to see if variations in aldehyde-metabolizing genes (ADH1B and ALDH family) are linked to lung cancer risk, especially in people who have never smoked. The goal is to understand how these genes might influence the developme…

This study will use artificial intelligence and 3D CT scans to predict how well a person's lungs will work after different treatments for early-stage lung cancer. About 192 adults with stage IA non-small cell lung cancer will be followed for two years after surgery or a minimally…

This study looks at how low body temperature during lung cancer surgery (using a tiny camera) affects pain and complications after the operation. About 144 adults having this surgery will have their temperature tracked continuously. The goal is to understand if getting cold durin…

This study will measure specific immune cells in the blood of 200 non-small cell lung cancer patients before and after surgery. The goal is to see if these markers can help predict if the cancer will come back or how long patients will live. Participants must have early-stage lun…

This study will collect blood samples from 620 adults with cancer (including lung cancer) to look for tiny markers released by tumors. Researchers want to see if these markers can help predict how well treatments work or when the cancer might come back. The study does not test a …

This large study will follow over 6,700 adults with obesity-related cancers (like breast, colorectal, or lung cancer) to track changes in their body fat and muscle using advanced imaging. The goal is to see how these changes relate to survival, cancer recurrence, and quality of l…

This pilot study looks at why some people develop chronic pain after chest surgery. Researchers will collect blood samples from 60 patients before and after surgery to measure certain molecules (cytokines) and check if changes in gene activity (epigenetics) are linked to long-ter…