Acute kidney injury

Critically ill adults with acute kidney injury or end-stage kidney disease often need continuous renal replacement therapy, a slow form of dialysis that runs for hours or days. Blood tends to clot in the dialysis circuit, so doctors add a blood thinner. This study tests whether r…

This study tested a new dialysis filter called ELISIO-HX in 22 adults with kidney failure. Participants used the new filter three times a week for 12 weeks. The goal was to see if it safely maintained albumin levels while improving removal of certain waste products. The trial is …

This trial tests whether levosimendan, a drug used to support the heart, can also improve kidney function in adults with acute kidney injury in intensive care. Participants receive either levosimendan or a placebo, and their kidney function is measured daily. The goal is to see i…

This study looked at whether giving a single dose of gabapentin before laparoscopic sleeve gastrectomy (weight-loss surgery) helps protect kidney function in people with severe obesity. 90 patients with normal kidney function were enrolled. Researchers measured kidney markers lik…

This trial tests two different concentrations of citrate solution used to prevent blood clotting during continuous kidney replacement therapy in critically ill patients with acute kidney injury. The goal is to see which concentration leads to fewer metabolic complications, such a…

This study tests whether the drug APX-115 can prevent kidney injury caused by contrast dye used in heart procedures. About 230 adults with kidney disease will receive either the drug or a placebo before and after their procedure. The goal is to see if the drug reduces kidney dama…

This study tested a single intravenous dose of TIN816, an enzyme that breaks down ATP to reduce inflammation, in 316 ICU patients with sepsis-related acute kidney injury. The goal was to see if it improves kidney function over 8 days and reduces major kidney problems by day 90. T…

This study looks at two treatments—plasma exchange (a blood-filtering procedure) and the drug daratumumab—to see if they help patients with multiple myeloma recover from acute kidney injury caused by light chain cast nephropathy. Researchers will track 450 adults to see who survi…

This study tested whether quickly alerting a kidney specialist team when hospitalized patients show signs of severe kidney disease could improve survival. Over 1,100 patients in France were included. The team of a nephrologist and pharmacist would help manage care during the hosp…

This study tested whether giving sodium bicarbonate (a common substance that neutralizes acid) to critically ill patients with severe metabolic acidosis and moderate-to-severe acute kidney injury could improve survival at 90 days. The trial enrolled 640 adults in the ICU who had …

This study tested whether metformin, a common diabetes drug, is safe and practical to use for treating acute kidney injury caused by sepsis. Researchers gave low-dose metformin to 80 ICU patients with sepsis and kidney injury, monitoring for side effects and feasibility. The goal…

This study looked at 120 critically ill patients with acute kidney injury and shock who needed dialysis. Researchers compared a special method called sodium profiling dialysis to standard dialysis to see if it helped keep blood pressure stable and reduced fluid buildup in the lun…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This study tested whether using sevoflurane gas for anesthesia during kidney transplant surgery helps the new kidney recover faster than standard propofol anesthesia. 120 adults receiving a kidney transplant were randomly assigned to one of the two anesthetics. Researchers tracke…

This study tested a new way to monitor kidney oxygen levels during liver surgery to try to prevent acute kidney injury (AKI). 80 adults having liver surgery were randomly assigned to either standard care or extra monitoring that triggered a step-by-step treatment plan if oxygen l…

This study tested whether adding regional citrate anticoagulation (RCA) to standard heparin can reduce clotting in continuous kidney dialysis circuits for patients on ECMO. Eighteen ICU adults with ARDS and acute kidney injury were enrolled. Each patient received alternating peri…

This study looked back at 400 critically ill patients with septic shock and kidney failure who needed dialysis. Researchers compared those who received a special filter (Oxiris) that removes toxins and inflammation-causing substances to those who got standard filters. The goal wa…

This study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach higher doses of life-saving heart medications (RAAS inhibitors) without dangerous potassium spikes. 112 adults with stable kidney disease and hear…

This study tested whether methylene blue, a dye that affects blood vessel function, can prevent dangerous drops in blood pressure during kidney dialysis. It involved 261 critically ill adults with acute kidney injury who needed dialysis. The goal was to see if the treatment could…

This study tested whether breathing in nitric oxide during and after heart surgery can prevent acute kidney injury. It included 250 adults with signs of blood vessel problems who were having long heart surgeries. Patients received either nitric oxide gas or a placebo (nitrogen) d…

This study looked at whether using a very small amount of contrast dye (less than 15 ml) is safe and works for opening blocked leg arteries in 18 patients with both severe leg ischemia and kidney impairment. The goal was to save the leg while protecting the kidneys. Results focus…

This study compares two medicines, terlipressin and octreotide, for treating hepatorenal syndrome—a serious kidney complication of advanced liver disease. Sixty adults aged 30 to 70 will receive one of the drugs, and doctors will check kidney function after 48 hours to see which …

This study tested whether citrate or heparin is better for keeping dialysis catheters working longer in ICU patients with sudden kidney failure. 405 adults were randomly assigned to receive either citrate or heparin as a catheter lock solution. The goal was to see which solution …

This study looked at whether giving nitric oxide gas during and after surgery could lower the risk of acute kidney injury in people undergoing emergency repair of a torn aorta. 106 adults were randomly assigned to receive nitric oxide or a placebo. The main goal was to see how ma…

This study tested whether a drug called ilofotase alfa can prevent kidney damage in people undergoing open heart surgery. 271 patients received either the drug or a placebo before and after surgery. The goal was to see if the drug could keep kidney function stable and reduce seri…

This study looked at whether adding the sedative dexmedetomidine to sevoflurane anesthesia could help prevent acute kidney injury after non-cardiac surgery. Researchers enrolled 90 patients undergoing total knee replacement. They measured changes in kidney function by checking bl…

This study tested a method to carefully remove extra fluid from critically ill patients with kidney failure who are on continuous dialysis. The goal was to keep their fluid levels balanced without causing dangerous drops in blood pressure. Researchers used advanced heart monitori…

This study looked at 1,424 veterans at high risk for heart problems who had major surgery. It compared two approaches to blood transfusion: a liberal strategy (transfusing when hemoglobin drops below 10) versus a restrictive strategy (transfusing only when hemoglobin drops below …

This study tested two types of dialysis—hemodiafiltration and hemofiltration—in 163 ICU patients with acute kidney failure. Patients received both methods in alternating order, and researchers measured how well each reduced waste products like urea in the blood. The goal was to s…

This study tested a drug called RMC-035 in 170 adults at high risk for kidney injury after open-chest heart surgery. Participants received three doses of the drug or a placebo during and after surgery. Researchers measured kidney function at 90 days to see if the drug helps prote…

This study tests whether a non-invasive light-based monitor, called near-infrared spectroscopy (NIRS), can detect kidney injury early in newborns with hypoxic-ischemic encephalopathy (HIE) who are undergoing cooling therapy. The monitor measures oxygen levels in the kidneys and b…

This study tests whether a non-invasive ultrasound measurement called the renal resistive index (RRI) can predict if acute kidney injury (AKI) will progress to a severe stage in intensive care unit (ICU) patients. Researchers will measure RRI in 120 adults with early-stage AKI wi…

This study tests whether a furosemide stress test can predict if acute kidney injury will get worse in ICU patients. Researchers will give furosemide to 140 patients and measure urine output over 2 hours. The goal is to see if the test can identify who will need dialysis, helping…

This study tests whether a quick urine measurement after a single dose of furosemide (a water pill) can predict which ICU patients with low albumin levels will develop severe acute kidney injury. Researchers will compare this test to blood biomarkers to see which is more accurate…

This study tested whether a urine test measuring two proteins (TIMP2 and IGFBP7) can tell which septic shock patients will recover normal kidney function within 72 hours. Researchers analyzed data from 77 patients in French ICUs. The goal is to help doctors decide who needs aggre…

This study tested a new urine test (RENISCHEM L-FABP) to see if it can predict acute kidney injury within 2 days after heart or blood vessel procedures that use contrast dye. Researchers measured a kidney stress marker in 382 adults at higher risk. The goal was to validate the te…

This study tested whether the Nephrocheck™ device can predict if early acute kidney injury will reverse within 72 hours in patients with septic shock. Researchers enrolled 184 adults in the ICU and measured the device's accuracy. The goal is to help doctors decide who might recov…

This study tested whether a special ultrasound score (called VEXUS) can predict acute kidney injury in women with severe preeclampsia when they are admitted to the hospital. Researchers examined 70 women using Doppler ultrasound to check blood flow in key veins. The goal was to s…

This study looked at whether a special light-based monitor (near-infrared spectroscopy) placed on the skin can help predict kidney injury after heart surgery. Researchers measured oxygen levels in the kidneys of 113 adults during surgery and checked if low levels were linked to l…

This study tested whether a fast removal of 250 ml of fluid during dialysis can predict which ICU patients with acute kidney injury are at risk of unstable blood pressure. Twenty adults on mechanical ventilation and continuous dialysis underwent two different speeds of fluid remo…

This study aims to create a better way to detect acute kidney injury early after heart surgery. Researchers will combine blood and urine tests with patient information to build a scoring system. The goal is to identify high-risk patients quickly so doctors can take steps to prote…

This study looked at 197 emergency room patients with rhabdomyolysis (severe muscle breakdown) to see if a blood test for a protein called NGAL could predict who would develop acute kidney failure within 48 hours. The goal is to help doctors identify high-risk patients earlier an…

This trial tests whether a software tool called the hypotension prediction index (HPI) can help prevent acute kidney injury after robotic-assisted urologic surgery. The tool uses arterial pressure data to forecast drops in blood pressure during the operation, allowing doctors to …

This study looks at whether giving L-Arginine soon after heart surgery that uses a heart-lung machine can lower the chance of acute kidney injury. It will follow over 5,000 adults in the intensive care unit after their operation. The goal is to see if this simple amino acid might…

This study tested whether giving caffeine early to preterm babies (born before 32 weeks) can prevent acute kidney injury. 236 newborns received either caffeine or standard supportive care within 24 hours of birth. Researchers tracked kidney injury, hospital stay length, and survi…

This study tested a 60% ethanol (alcohol) lock solution to prevent serious catheter infections in 1,460 ICU patients with acute kidney failure needing dialysis. The ethanol lock is placed inside the catheter to kill germs. The goal was to see if it reduces major catheter-related …

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This study tested whether giving the acid-reducing drug pantoprazole during heart surgery could prevent acute kidney injury, a common complication. One hundred adults at moderate-to-high risk for kidney damage were randomly assigned to receive either pantoprazole or another acid …

This study tested whether giving a bicarbonate solution (like baking soda) is better than standard saline for preventing kidney injury caused by contrast dye used in imaging. The trial involved 300 adults in intensive care who needed contrast dye. Researchers compared how many pa…

This study tested whether giving fluids as a quick bolus or as a continuous drip works better to prevent kidney injury caused by contrast dye used in CT scans. The trial included 285 emergency department patients with high creatinine levels. Researchers measured kidney function 4…

This large study tested whether giving sodium bicarbonate (a type of fluid) or N-acetylcysteine (a supplement) before and after angiography could prevent serious kidney problems, including death or need for dialysis. Over 5,000 high-risk patients with kidney disease took part. Th…

This study tested whether giving activated vitamin D (calcifediol and calcitriol) to critically ill patients in the ICU could prevent or lessen acute kidney injury (AKI). Researchers enrolled 150 adults at high risk for AKI. The goal was to see if this treatment could reduce deat…

This study tested whether a non-invasive procedure called remote ischemic preconditioning (RIPC) can prevent kidney damage caused by contrast dye in diabetic patients undergoing coronary angiography. The procedure involves using a blood pressure cuff to briefly restrict blood flo…

Researchers are testing whether oral N-acetylcysteine (NAC) can reduce signs of kidney tubular injury, oxidative stress, and inflammation in adults with non-severe leptospirosis. The trial enrolls 64 adults who have had fever for three to five days and a confirmed Leptospira infe…

This study looked at 516 patients who had surgery for a torn aorta (aortic dissection). Researchers checked if a high ankle-brachial index (a simple test of blood flow in the legs) before surgery was linked to kidney problems afterward. The goal was to see if this test could help…

This study is looking for new markers in blood and urine that could predict kidney injury after heart surgery in high-risk patients. Researchers will follow about 1,500 adults undergoing open-heart surgery and check for kidney problems within a week. The goal is to find better wa…

Researchers are studying whether children born prematurely who had acute kidney failure as newborns show signs of reduced kidney function later in childhood. The study compares about 50 preterm children with a history of neonatal kidney failure to 25 preterm children without it. …

This study follows about 36 children weighing 2.5-10 kg who have acute kidney injury or fluid overload and are treated with the Carpediem continuous renal replacement therapy system. Researchers will track survival, kidney recovery, and hospital stay lengths to see how well the d…

This study looks back at treatment records from 119 people with kidney failure who underwent haemodialysis using Genius SleddFlux filters, Ultraflux AV 600 S filters, and Genius 90 concentrates. The goal is to assess how well these devices performed in acute and chronic dialysis …

This study follows adults who had a severe form of acute kidney injury (AKI) during a hospital stay. Researchers will use non-invasive tests to measure body composition and kidney size, and review medication plans. Participants will also be contacted by phone at 90 days and 12 mo…

This study looks at whether the way you sleep before heart surgery is connected to problems like confusion (delirium) or kidney damage after the operation. Researchers will track 549 adults having planned heart surgery with a heart-lung machine. The goal is to find patterns that …

This study aims to improve how emergency dialysis is delivered in Alberta hospitals. Researchers will test a new care pathway in 18 intensive care units to see if it can lower costs and improve patient outcomes. About 4,500 adults and children receiving acute dialysis will take p…

This study uses a dye called iohexol to measure how well the kidneys are working in patients leaving the intensive care unit after acute kidney failure. The goal is to find out how many patients still have reduced kidney function even though their standard blood tests look normal…

This study looked at 110 adults having nose surgery (septoplasty) to see if different blood pressure targets during surgery affect kidney injury. Patients were split into two groups: one with a lower blood pressure target (50-57 mmHg) and one with a higher target (58-65 mmHg). Ki…

This study looked at 287 patients with acute kidney injury caused by tubular necrosis. Researchers measured two substances in urine (PIIINP and NGAL) to see if they could predict whether kidney function would return or if chronic kidney disease would develop. The goal is to find …

This study looked at 398 adults who needed a temporary dialysis catheter, comparing those who got it in the emergency department versus those who got it in the dialysis unit. Researchers tracked infections and blood clots in the catheter for 10 days after placement. The goal is t…

This study looked at 155 critically ill patients on ventilators to see if the difference between carbon dioxide in their breath and blood could predict acute kidney injury. Researchers measured this gap over the first 24 hours in the ICU. The goal was to find a simple, early warn…

This study followed 400 intensive care patients receiving beta-lactam antibiotics to see how often these drugs cause brain-related side effects like confusion or agitation. Researchers measured antibiotic levels in the blood and checked patients' neurological status several times…

This study looked at 174 adults in the intensive care unit (ICU) to find out how often acute kidney injury happens and what factors make it more likely. Researchers tracked patients who stayed in the ICU for at least 48 hours, excluding those with kidney problems at the start. Th…

This completed study looked at 170 adults who needed emergency hemodialysis for acute kidney injury. Researchers measured three blood markers (Activin A, Nostrin, and Angiopoetin-2) before dialysis to see if they could predict whether the kidneys would recover or if the patient w…

This study reviewed the records of 150 adults who had surgery to clear blood clots from the lung arteries. Researchers wanted to see who developed kidney injury within two days after surgery and what factors raised that risk. They looked at things like how long the patient was on…

This study looked at whether intentionally lowering blood pressure during nose surgeries (like rhinoplasty) might cause hidden kidney injury. Researchers measured two sensitive kidney biomarkers (NGAL and cystatin C) in 35 adults before and after surgery. The goal was to detect e…

This study looked at 1416 very sick adults in the ICU to see how well different stages of acute kidney injury (AKI) match the kidneys' actual ability to filter waste. Researchers used a urine test to measure kidney function and compared two common ways to diagnose AKI: one based …

This completed study looked at 211 people with sepsis, some of whom also had acute kidney injury. Researchers measured specific microRNAs and other markers in the blood to understand how kidney damage happens. The goal was to find new targets for diagnosis or treatment, not to te…

This study looked at whether giving antibiotics before a kidney drainage procedure (called percutaneous nephrostomy) prevents urinary tract infections in cancer patients whose urinary tract is blocked by a tumor. Researchers reviewed records of 320 cancer patients who had the pro…

This study looked at nearly 30,000 older adults (65+) having non-cardiac surgery to see if levels of homocysteine, a natural amino acid, could predict serious complications like kidney injury or death. Researchers measured homocysteine before and after surgery. The goal was to se…

This study looked at 100 critically ill adults with severe kidney failure who were receiving continuous kidney replacement therapy. Researchers used a special ultrasound technique to check for fluid buildup in the body, which can harm organs. The goal was to see how common fluid …

This completed study looked at over 3,000 heart surgery patients who developed acute kidney injury. Researchers tested new biomarkers to see if they could predict which patients would get worse. The goal is to help doctors identify high-risk patients earlier and improve care.

This study looked at how a 10 km run and a 1.5 km swim affect kidney function in 40 healthy, active adults. Researchers used sensitive urine tests to detect subtle kidney changes that standard blood tests might miss. The goal was to better understand temporary kidney stress from …

This study looked at 174 older adults (ages 65-80) having lumbar fusion surgery to see whether using sodium acetate Ringer's solution or sodium lactate Ringer's solution during the operation better protects the kidneys. Researchers measured early kidney injury markers in urine an…

This completed study collected blood, urine, and kidney tissue from 90 COVID-19 patients with acute kidney injury. Researchers aimed to build a biorepository and analyze samples to better understand how COVID-19 affects the kidneys. The goal is to speed up discoveries and improve…

This study looked at how often acute kidney injury happens in people with liver cirrhosis, and what factors might increase the risk. Researchers at Sohag University Hospital followed 180 adult patients with cirrhosis, excluding those with pre-existing kidney disease or other majo…

This study looked at how a nerve condition called cardiovascular autonomic neuropathy (CAN) affects the risk of kidney injury in people having heart bypass surgery. Researchers tracked 912 adults before, during, and after surgery to see if those with CAN had worse kidney function…

This completed study looked at whether levels of a protein called angiotensinogen in blood and urine can predict long-term kidney function in people who had acute kidney injury. Researchers followed 80 patients for three years to see if this biomarker could help identify those at…

This pilot study looked at whether giving extra oxygen during heart surgery (when a heart-lung machine is used) affects kidney function afterward. 104 adults having elective heart surgery were randomly assigned to receive either high or normal oxygen levels. The main goal was to …

This completed study looked at whether a protein called vasorin in the blood can help predict how severe kidney injury will be in people with septic shock. Researchers took blood samples from 50 intensive care patients on day 0 and day 3. The goal was to see if vasorin levels are…

This study looked at over 5,000 critically ill children from hospitals worldwide to learn more about acute kidney injury (AKI). The goal was to better understand how common AKI is, what puts children at risk, and how to predict it using a tool called 'renal angina.' The study did…

This study looked at 43 critically ill adults with acute kidney injury who needed continuous kidney replacement therapy (CRRT). Researchers measured how much of certain nutrients—like carnitine, vitamins, and amino acids—were removed during dialysis. The goal was to understand if…

This study looks at whether heparin or citrate locks used in dialysis catheters leak into the bloodstream. It involves 76 adults with acute kidney failure. Researchers measure blood clotting and calcium levels before and after injecting the lock to check for leakage and potential…

This study measured certain proteins in the blood and urine of 20 newly diagnosed multiple myeloma patients before and 30 days after starting daratumumab. The goal was to see if these markers could help detect early kidney injury. Participants provided samples during routine lab …

This study reviewed 575 adults admitted to intensive care for a severe kidney infection called acute obstructive pyelonephritis. Researchers aimed to identify factors that lead to poor outcomes such as death or lasting kidney damage. The goal is to better understand which patient…

This study looked at medical records of 59 children weighing 8-20 kg who needed a type of kidney dialysis called CRRT. Researchers compared outcomes between those who used a newer filter (HF20) and those who used an older one (M60). The goal was to see if the newer filter helped …

This study looked back at 455 adults who had heart surgery with a heart-lung machine. Researchers wanted to see if routine blood tests and other factors before surgery could predict acute kidney injury, a serious complication. They found that certain markers of inflammation and k…

This study compares two blood-filtering techniques—plasma exchange and immunoadsorption—in 40 patients with severe kidney failure caused by ANCA vasculitis or Goodpasture disease. The goal is to see which method removes disease-causing antibodies more quickly. Results may help do…

This study looked at 76 ICU patients with severe pneumonia who were placed on a lung machine (ECMO) and given minimal ventilator support. Researchers wanted to see if this approach changed how well the kidneys worked. They reviewed medical records from 2019 to 2023, comparing uri…

This study tested a prediction tool that uses routine lab results to estimate a patient's risk of kidney injury after heart surgery. Researchers looked at data from 2,500 adults who had heart surgery to see how well the tool worked. The goal is to help doctors catch kidney proble…

This study looked at whether taking ibuprofen before running in the heat increases signs of kidney injury. Twelve healthy adults took either ibuprofen or a placebo before running for an hour in a hot room. Researchers measured kidney injury markers in urine and blood before, righ…

This study looked at 380 adults in the intensive care unit with suspected or confirmed COVID-19. Researchers tracked organ problems like kidney injury and lung failure, and measured survival rates at 30 days and one year. The goal was to learn how COVID-19 causes organ damage, no…

This study tested whether a machine learning model could predict kidney injury caused by platinum chemotherapy more accurately than doctors. Researchers followed 77 cancer patients receiving cisplatin or carboplatin, tracking their kidney function over time. The goal was to see i…

This study looked at whether continuous kidney replacement therapy can cause temporary heart muscle weakness (myocardial stunning) in critically ill patients with severe acute kidney injury. Researchers used echocardiograms to measure changes in heart wall motion in 42 adults. Th…

This study looked at anonymous medical records from over 55,000 past ICU patients to find patterns that could help predict three life-threatening conditions: sepsis (body-wide infection), ARDS (severe lung injury), and acute kidney injury. Researchers used computer models to anal…

This study looked at nearly 6,000 ICU patients with severe kidney injury to see if a scoring tool called UNDERSCORE can predict when dialysis can be safely stopped. The goal was to avoid restarting dialysis or early death within 7 days. Researchers used existing hospital data to …

This study reviewed medical records of 274 adults who had emergency surgery for a torn aorta (aortic dissection). Researchers looked at how often patients had brain complications like stroke or coma after surgery and whether those complications led to longer stays in the intensiv…

This study tested a computer system that alerts pharmacists about potential kidney failure or high potassium risks in older hospital patients. Researchers wanted to see if these alerts, combined with pharmacist reviews, could reduce serious side effects from medications. The stud…

This study looked at whether a heart ultrasound (echocardiography) can help doctors better manage liver cirrhosis patients who also develop sudden kidney injury. Researchers examined 28 patients to see how their heart function related to their kidney problem. The goal was to impr…

This study looked at 80 adults on heart-lung support (ECMO) who also needed kidney dialysis (CRRT). Researchers compared two methods of connecting the machines to see which made the dialysis circuit last longer. The goal was to find a better approach for managing these complex tr…

This completed study of 88 heart attack patients looked at why some develop kidney injury after receiving contrast dye during a procedure to open blocked arteries. Researchers analyzed medical records to find which factors—like age, lab results, or procedure details—were linked t…

This study looked at hospitalized adults who needed the antibiotic vancomycin. Participants were randomly assigned to receive it as a continuous drip or as intermittent doses. Researchers measured kidney function and injury markers to see if one method is gentler on the kidneys.

This study looked at whether a simple blood test score, called the CALLY index, can help predict how well adult sepsis patients will do in the intensive care unit (ICU). Researchers reviewed medical records of 276 patients to see if the CALLY index was linked to the risk of death…

This completed study interviewed 28 people who had sepsis-associated acute kidney injury (SA-AKI) to learn about their symptoms, impacts, and treatment experiences. Participants shared their perspectives in 60-minute interviews. The goal was to better understand what patients go …

This study looked at whether using dialysis less often helps people recover from acute kidney injury that requires dialysis. 220 hospitalized adults were assigned to either a conservative (less frequent) dialysis plan or the usual thrice-weekly schedule. The goal was to see if th…

This study tested an experimental drug called TIN816 in 20 adults in the intensive care unit who had kidney injury from sepsis. The main goal was to learn how the drug behaves in the body and whether it is safe. This was an early-stage study, so it focused on gathering informatio…

This study tested whether having a clinical pharmacist work alongside doctors in a hospital ward could reduce medication errors in patients with kidney disease. Researchers followed 160 adults with reduced kidney function, comparing usual care, doctor education, and active pharma…

This study looked at 39 intensive care patients with acute kidney failure who needed dialysis to remove excess fluid. Researchers tested three different fluid removal rates (1, 2, and 3 ml per kg per hour) to see which caused the fewest drops in blood pressure while still effecti…

This pilot study tested whether using ultrasound to check fluid tolerance is feasible in hospitalized patients with acute kidney injury (AKI). 80 non-ICU adults were randomly assigned to receive either standard care or an ultrasound-guided fluid assessment. The main goal was to s…

This study looked at 319 patients who needed dialysis for severe acute kidney injury. Researchers collected their medical information to identify risk factors for developing chronic kidney disease. The goal was to create a scoring system that helps doctors decide which patients w…

This study tested a new way to send alerts to doctors when a patient develops acute kidney injury (AKI). Instead of alerting for every case, the system used a model to identify which patients would benefit most from the alert. Over 2,000 adults with AKI in the hospital were inclu…

This study looked back at the medical records of 238 severely burned adults who needed continuous kidney therapy (CRRT) in the intensive care unit. The goal was to see how the timing of starting CRRT and the severity of kidney injury related to survival and how long patients stay…

This study looked at whether continuing or temporarily stopping the blood pressure medicine Ramipril (an ACE inhibitor) before coronary angiography affects the risk of kidney injury from the contrast dye. 44 adults were randomly assigned to either keep taking their usual dose or …

This study tested whether a computer system that alerts pharmacists about patients at risk for drug-related kidney injury can help doctors make safer medication decisions. The trial involved 698 hospitalized adults across eight hospitals. Pharmacists reviewed alerts and made reco…