Kidney shield? sedative drug may protect against Surgery-Related kidney damage
NCT ID NCT06835010
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether adding the sedative dexmedetomidine to sevoflurane anesthesia could help prevent acute kidney injury after non-cardiac surgery. Researchers enrolled 90 patients undergoing total knee replacement. They measured changes in kidney function by checking blood creatinine levels. The goal was to see if dexmedetomidine offers kidney protection through immune and antioxidant effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dexmedetomidine (a sedative drug) and sevoflurane (an inhaled anesthetic)
What this could lead to
If it works, this could point toward a way to reduce the risk of acute kidney injury after major surgery.
What could go wrong
This is a small, completed study with only 90 participants, all women, so results may not apply to men or larger populations. The findings are preliminary and need confirmation.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Tanta University
Tanta, El Gharbyia, 13511, Egypt