Kidney shield? sedative drug may protect against Surgery-Related kidney damage

NCT ID NCT06835010

Completed Disease control Sponsor: Tanta University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding the sedative dexmedetomidine to sevoflurane anesthesia could help prevent acute kidney injury after non-cardiac surgery. Researchers enrolled 90 patients undergoing total knee replacement. They measured changes in kidney function by checking blood creatinine levels. The goal was to see if dexmedetomidine offers kidney protection through immune and antioxidant effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dexmedetomidine (a sedative drug) and sevoflurane (an inhaled anesthetic)
What this could lead to: If it works, this could point toward a way to reduce the risk of acute kidney injury after major surgery.
What could go wrong: This is a small, completed study with only 90 participants, all women, so results may not apply to men or larger populations. The findings are preliminary and need confirmation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AKI - ACUTE KIDNEY INJURY

Contacts and locations

Locations

Tanta University

Tanta, El Gharbyia, 13511, Egypt

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