Can a protein shield your kidneys during Open-Heart surgery?
NCT ID NCT06475274
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a drug called RMC-035 in 170 adults at high risk for kidney injury after open-chest heart surgery. Participants received three doses of the drug or a placebo during and after surgery. Researchers measured kidney function at 90 days to see if the drug helps protect the kidneys and is safe.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- RMC-035 (a protein given by IV infusion)
- What this could lead to
- If it works, this could point toward a treatment to protect kidneys from damage after heart surgery.
- What could go wrong
- This is a phase 2b dose-finding study with only 170 participants, so results are preliminary. The drug may not improve kidney function or could cause unexpected side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Research site 1
Toronto, Canada
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Research site 1
Hradec Králové, Czechia
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Research site 1
Münster, Germany
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Research site 1
Madrid, Spain
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Research site 2
Québec, Canada
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Research site 2
Prague, Czechia
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Research site 2
München, Germany
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Research site 2
Madrid, Spain
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Research site 3
Saint John, Canada
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Research site 3
Essen, Germany
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Research site 3
Barcelona, Spain
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Research site 4
Montreal, Canada
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Research site 4
Halle, Germany
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Research site 4
Córdoba, Spain
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Research site 5
Montreal, Canada
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Research site 5
Dresden, Germany
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Research site 5
Santiago de Compostela, Spain
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Research site 6
Giessen, Germany
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Research site 6
Pamplona, Spain