New drug aims to shield kidneys during heart surgery

NCT ID NCT06475274

First seen Nov 01, 2025 · Last updated May 07, 2026 · Updated 30 times

Summary

This study tested a drug called RMC-035 to see if it can protect kidney function in people at high risk for kidney injury after open-chest heart surgery. 170 adults received either a high dose, low dose, or a placebo during and after surgery. Researchers measured kidney function and safety up to 90 days after surgery to find the best dose.

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Contacts and locations

Locations

  • Research site 1

    Toronto, Canada

  • Research site 1

    Hradec Králové, Czechia

  • Research site 1

    Münster, Germany

  • Research site 1

    Madrid, Spain

  • Research site 2

    Québec, Canada

  • Research site 2

    Prague, Czechia

  • Research site 2

    München, Germany

  • Research site 2

    Madrid, Spain

  • Research site 3

    Saint John, Canada

  • Research site 3

    Essen, Germany

  • Research site 3

    Barcelona, Spain

  • Research site 4

    Montreal, Canada

  • Research site 4

    Halle, Germany

  • Research site 4

    Córdoba, Spain

  • Research site 5

    Montreal, Canada

  • Research site 5

    Dresden, Germany

  • Research site 5

    Santiago de Compostela, Spain

  • Research site 6

    Giessen, Germany

  • Research site 6

    Pamplona, Spain

Conditions

Explore the condition pages connected to this study.