STROKE

This study tests if a newer blood thinner called apixaban works better and causes fewer side effects than the standard drug warfarin in people with advanced heart failure who have a HeartMate 3 heart pump. About 460 adults who have had the pump for at least 3 months will be rando…

This study tests whether a robotic arm treatment can improve arm movement in people who had a stroke more than 6 months ago. Sixty right-handed adults with mild to moderate arm weakness will receive 15 robotic therapy sessions over three weeks, plus standard rehab. Researchers wi…

This study tests whether giving a clot-busting drug (tenecteplase) directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 344 adults with large vessel occlusion stroke will be randomly assigned to receive the drug or a…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The program includes digital tools, personalized guidance, and ongoing support. Researchers will compare it…

This study tests whether a drug called ulinastatin can lower the chance of having a stroke after brain tumor surgery. Strokes, including ones that are hard to notice, are common after these operations. The trial will give 1,370 patients either ulinastatin or a placebo before and …

This study tests whether a brain implant can help people who had a stroke regain movement in their arm. Ten participants will first do standard rehab, then get the implant and continue rehab for six months. The goal is to see if the device is safe and helps improve arm function.

This study tests whether a clot-dissolving drug called tenecteplase works better than standard antiplatelet pills for people who have had a mild but disabling stroke caused by a large blocked artery. The treatment is given 4.5 to 24 hours after symptoms start. About 864 adults wi…

This study looks at whether a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar after a stroke can lead to worse outcomes. The trial will involve 82 adul…

This study looks at doing two heart procedures at the same time in people with atrial fibrillation (an irregular heartbeat). The first uses targeted energy to fix the heart's electrical signals, and the second closes a small pouch in the heart to lower stroke risk. Researchers wa…

This study tests whether cooling the head (using a special cap) during emergency stroke treatment can reduce the amount of brain tissue that dies. About 182 adults having a major stroke and undergoing a clot-removal procedure will be randomly assigned to receive either standard c…

This study tests whether adding relaxin, a natural hormone, to standard care can reduce abnormal heart rhythms in 208 veterans with atrial fibrillation who are scheduled for a heart procedure called catheter ablation. The goal is to see if relaxin lowers the daily burden of atria…

This early study tests if a drug called RK-4 can be safely injected through the skull into the brain for people with a severe stroke. The goal is to see if this method works and is safe for patients who cannot get standard treatments. Only 6 adults aged 18 to 80 with a first-time…

This study tests two devices, Supernova and Neutron, that doctors use to remove blood clots from large brain arteries in people having a stroke. The goal is to restore blood flow within 24 hours of symptoms starting. About 3,000 participants will be followed for 90 days to see if…

This study tests a new, drug-free treatment for people having an ischemic stroke (a clot blocking blood flow to the brain). The approach uses two devices: a blood pressure cuff on the arm that briefly restricts blood flow, and inflatable leg sleeves that pump blood upward. The go…

This study tests whether cooling the brain directly through a catheter, combined with standard clot removal, helps people recover from a severe stroke. About 322 adults with a large stroke will be randomly assigned to receive either the cooling plus clot removal or clot removal a…

This study tests if a single daily polypill (combining blood pressure, cholesterol, and anti-clotting drugs) can reduce the risk of another stroke or heart attack in 500 recent stroke patients in Ghana. Participants will take the polypill or receive usual care for 24 months. The …

This study tests a gentler balloon angioplasty procedure to improve blood flow in people with severely narrowed brain arteries that have already caused a minor stroke. The goal is to see if the procedure is safe and can prevent future strokes. About 159 participants who recently …

This study tests whether a low-dose daily pill called colchicine can help people recover better and avoid future heart attacks or strokes after a brain hemorrhage. About 1,125 adults who have had a brain bleed and also have signs of artery disease will take either colchicine or a…

This study tests if a new device (Cocoon PFO Occluder) is as safe and effective as the standard device (Amplatzer) for closing a small hole in the heart called a PFO. The hole can let blood clots travel to the brain, causing strokes. About 1,260 adults who had a stroke or mini-st…

This study tests whether adding a WhatsApp-based education and counseling program to standard care helps stroke patients with type 2 diabetes improve their healthy habits, blood sugar control, and diabetes knowledge. About 84 participants will be split into two groups: one gets r…

This study tests whether adding a drug called GM1 to standard clot-removal treatment helps people recover better after a major stroke. About 868 adults with a blocked artery in the front part of the brain will receive either GM1 or a placebo. The goal is to see if more patients c…

This study tests whether a procedure that closes off a small heart pouch (left atrial appendage occlusion) combined with a heart-rhythm correction (catheter ablation) is safer and more effective than ablation plus daily blood thinners for frail patients aged 75 and older with atr…

This study tests whether lying flat (0 degrees) or with the head elevated (30 degrees or more) after a stroke clot removal procedure helps patients recover better. About 2,240 adults who had a stroke from a large blood vessel blockage will be randomly assigned to one of the two h…

This study tests a program called Moxie that sends weekly health tips by mail and offers a mobile app to help people manage chronic conditions like heart disease, diabetes, and kidney disease. The goal is to see if it reduces the number of times people are readmitted to the hospi…

This study tests a community-based exercise program for adults aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, or arthritis. The goal is to see if personalized exercise can improve heart and muscle fitness, mobility, and overall well-b…

This study will test a small, portable MRI machine to see how well it can detect brain injuries from lack of oxygen or blood flow in children. About 200 children in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version can acc…

This study checks if an AI program can help less-experienced doctors read stroke MRIs as accurately as a brain scan specialist. About 500 adults with stroke symptoms will take part. The goal is to see if AI can speed up and improve stroke diagnosis, not to test a new treatment.

This study will test whether an artificial intelligence (AI) system can accurately assess stroke severity by analyzing video and audio of patients. About 297 adults with a recent stroke will participate. If successful, the AI could help doctors make faster, more consistent treatm…

This study looks at whether new web-based tests on a tablet can accurately detect visuospatial neglect—a condition where stroke survivors ignore one side of space. About 105 stroke patients will take both digital and traditional paper-and-pencil tests. The goal is to see if the d…

This study tests whether extra balance training and fall-risk education during hospital rehab can prevent falls after stroke patients go home. About 134 participants will be split into two groups: one gets the extra therapy, the other gets usual care. Researchers will track falls…

This study compares apixaban alone versus apixaban plus clopidogrel in 586 adults who recently had a stroke due to atrial fibrillation and hardened brain arteries. Participants take either one or two blood thinners for 30 days. The goal is to see if the combination better prevent…

This study tests whether the drug cilostazol can prevent another stroke or heart attack in 1,100 people in Ghana who recently had a stroke. Participants take cilostazol or a placebo twice a day for two years, along with their usual aspirin or clopidogrel. The goal is to see if th…

This study tests whether a gentle brain stimulation technique called tDCS, combined with standard rehabilitation, can prevent the development of chronic pain after a stroke. Researchers will enroll 60 stroke survivors who are at high risk for pain and give half of them real stimu…

This study tests whether electronic alerts in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goal …

This study tests whether allowing the pelvis to move freely during robot-assisted walking training helps stroke survivors walk better, improve balance, and feel less afraid of falling. About 36 adults who had a stroke at least 6 months ago will receive either pelvic-free or pelvi…

This study looks at whether intensive music therapy can improve thinking skills like memory and attention in people recovering from a stroke. It involves 36 adults who had a stroke within the last 3 months and have mild to moderate cognitive issues. The goal is to see if music th…

This study tests whether a gentle brain stimulation technique called tDCS, combined with hand muscle electrical therapy, can improve hand function in people who had a stroke. Fifty-six participants will receive either real or fake tDCS for 20 sessions over four weeks. Researchers…

This study tests a new training method called MINT that uses muscle signals to control a computer interface, aiming to improve walking after a stroke. About 72 adults who had a stroke at least 6 months ago and have trouble walking will participate. The goal is to see if this appr…

This study tests a new virtual reality (VR) walking program for people with traumatic brain injury or stroke. Participants will use a VR headset while walking overground, and their progress will be tracked with a Fitbit and walking tests. The goal is to see if this immersive ther…

This study tests a new, gentle brain stimulation technique called kTMP to help people who had a stroke and still have arm weakness. Researchers will measure if this method improves arm and hand movement. The study plans to enroll 100 adults aged 18-80 who have had a stroke.

This study tests a web-based program that combines physical exercises with brain games for people who had a stroke at least 6 months ago. Researchers want to see if doing these activities at home for 12 weeks can improve walking, balance, memory, and attention compared to usual c…

This study tests whether a gentle vibration treatment, called focal vibration therapy, can reduce shoulder pain in people who have had a stroke. About 60 adults with chronic stroke and shoulder pain will receive either the vibration treatment plus standard rehab, or a fake treatm…

This study tests whether a virtual home rehabilitation program helps stroke survivors in underserved Texas communities recover better than usual care alone. About 80 participants will use a tablet-based program to improve daily activities and mobility. The goal is to make rehab m…

This study tests whether a virtual reality (VR) rehab program done at home can help people with stroke or Parkinson's disease improve their movement and thinking skills. Sixty adults will either use a VR headset for rehab sessions or receive standard in-person therapy. The goal i…

This study tests whether a single session of a mental practice technique called PETTLEP-based Action Observation and Motor Imagery (AOMI) can immediately improve arm movement in stroke survivors. Participants watch and mentally rehearse a reaching task, while a control group does…

This study will test a wearable grasping neuroprosthesis—a device that uses mild electrical stimulation to help open the hand—in two stroke survivors who have trouble extending their fingers. Participants will use the device at home for one year, with regular check-ins to see if …

This study tests three different high-intensity walking training programs in 20 stroke patients during inpatient rehab. The goal is to find which approach best improves balance, walking speed, and endurance. Participants will be randomly assigned to one of the three programs, and…

This study tests whether adding posture-oriented kinesio taping to standard rehabilitation helps stroke survivors improve their mobility, balance, coordination, and ability to perform daily tasks. About 60 adults who had a stroke at least one month ago and have trouble with postu…

This study tests whether adding immersive virtual reality to stationary cycling helps people who have had a stroke walk better. Twenty-five adults who are at least 6 months post-stroke will try the combined therapy or standard physiotherapy alone. Researchers will measure changes…

This study tests whether a device that delivers frequency-tuned electromagnetic fields can safely improve arm function in people who had a stroke 6 months to 5 years ago. 25 adults aged 18-80 with moderate arm weakness will use the device in clinic and at home for 3 months. The m…

This study tests a new type of physical therapy using augmented reality (AR) to help people who have had a stroke improve their balance and ability to move. The therapy, called AR-FIT, uses special glasses to add digital objects into the real world during exercises. Researchers w…

This study tests whether virtual reality (VR) exercises can help people who had a stroke within the last three months improve arm and hand function and promote brain healing. Forty adults aged 50-65 will use VR games as part of their therapy. Researchers will measure arm movement…

This study tests whether a home-based music rehabilitation program can improve attention and processing speed in stroke survivors. About 36 adults in Malaysia who had a stroke within the past year will participate. They will use music exercises at home, and researchers will measu…

This study tests whether adding thinking tasks to arm and hand exercises helps stroke survivors recover better than standard therapy alone. Twenty adults aged 40-70 with mild to moderate arm weakness will be split into two groups and trained for eight weeks. Researchers will meas…

This study tests whether adding functional electrical stimulation (FES) to task-oriented training improves arm and hand function in people who have had a stroke and still have muscle tightness. About 40 adults who have already received Botox for arm spasticity will be randomly as…

This study tests whether a special wearable suit that delivers mild electrical stimulation can quickly reduce muscle stiffness (spasticity) and improve arm, leg, and walking function in people who have had a stroke. 26 participants will wear the suit for one hour and be tested be…

This study tests a structured strength training program (FaStEx) for people who feel very tired after a stroke. Sixteen participants will either do supervised strength exercises twice a week plus home activity, or just home activity alone, for eight weeks. The goal is to see if t…

This study tests a new, low-cost robotic walking device designed for home use by people who have had a stroke. Twenty adults with walking problems after a first stroke will either use the device at home plus usual care, or just usual care, for 12 weeks. The goal is to see if the …

This study tests whether a trained volunteer visiting a stroke survivor at home for 8 weeks can make it easier to cope after leaving the hospital. About 840 people who had a stroke and are returning home will either get this extra support or just their usual care. Researchers wil…

This study compares 3D-printed splints with traditional splints to see which helps stroke survivors recover arm function better. One hundred adults with chronic stroke and mild to moderate arm weakness will receive 20 sessions of task-oriented therapy over four weeks. The goal is…

This study tests a personalized robotic telerehabilitation program for people who have arm weakness after a stroke. Participants use a wearable robotic device with virtual reality exercises at home, supervised remotely. The goal is to improve arm movement and daily function compa…

This study looks at whether special glasses called Fresnel prisms can help stroke survivors who have trouble seeing on one side. The glasses may improve balance, walking, and daily activities. About 50 adults who had a stroke 1-3 months ago will either get the glasses plus regula…

This study looks at whether raising the head of the bed 30 degrees and playing Quran recitation (murottal therapy) can help stroke patients with blood pressure, pain, and vomiting. About 112 Muslim stroke patients will receive this added to standard care for 3 days. The goal is t…

This study will test a non-invasive device called the Spatial StimeMD (SSMD) in 120 adults aged 18-80 who have had a stroke, traumatic brain injury, spinal cord injury, or peripheral nerve damage within the past 2 years. The device uses gentle stimulation to help improve arm and …

This study tests a new rehab program that uses multiple technologies to help people recover mobility after a stroke. About 62 participants will use the program, and their progress will be compared to stroke patients who received standard care. The goal is to see if the tech-based…

This study tests whether shining a low-level laser on the wrist can reduce muscle tightness (spasticity) and improve hand function in 40 stroke survivors aged 45 to 60. Participants will receive laser therapy, and researchers will measure changes in spasticity, grip strength, mus…

This study tests a device called BurtVision that combines a robotic arm with augmented reality games to help people who had a stroke at least 6 months ago. The goal is to see if playing games that use one or both arms can improve how often and how well they use their affected arm…

This study tests whether a virtual reality (VR) system called VALOR can help stroke survivors improve arm and hand function from home. About 48 adults who had a stroke at least 3 months ago will either use the VR program or receive standard care. The goal is to see if VR-guided p…

This study looks at whether combining Frenkel exercises (repetitive movements to improve coordination) with electrical muscle stimulation (gentle electrical pulses that make muscles contract) can help stroke patients aged 50-65 improve their balance, coordination, and body awaren…

This study tests whether a home-based stroke rehabilitation program called PEER-HOMEcare is practical and helpful for adults recovering from stroke. The program adapts the home environment with support from therapists and family to encourage brain recovery and engagement. About 4…

This study tests whether combining robot-assisted walking training with a mild electrical stimulation of the spinal cord can help people who have had a stroke and cannot walk. Twenty chronic stroke survivors will receive the combined therapy to see if it is feasible and improves …

This study will test whether adding robotic leg training to standard physical therapy helps stroke survivors feel better emotionally and physically. About 36 adults who had a stroke at least 3 months ago will receive either robot-assisted walking training or treadmill training, p…

This study compares early task-oriented rehabilitation (practicing real-life activities like walking or dressing) with traditional physical therapy for people who recently had a stroke. About 158 adults with ischemic or hemorrhagic stroke will start therapy within 48 hours and be…

This study tests robotic leg braces (exoskeletons) to help people who have had a stroke walk more easily. Twenty adults who had a stroke at least 6 months ago will try these devices indoors and outdoors. The goal is to see if personalized hip and ankle assistance can improve walk…

This study tests whether playing specially designed AI-based video games can improve thinking skills and arm function in people who have had a stroke. Forty adults aged 45-60 who are at least six months post-stroke will participate. They will use a smartphone app for cognitive te…

This study tests whether adding occupation-based bilateral arm training (practicing meaningful daily activities with both arms) to standard therapy helps stroke survivors improve arm movement and daily participation. 150 adults with a first stroke within the last 6 months will be…

This study tests a gentle, non-invasive brain stimulation method (tACS) to see if it can improve working memory in people who have trouble thinking after a stroke. Twenty-four adults who had a stroke 1-6 months ago will receive either real or fake stimulation for 40 minutes daily…

This study tests a new way to improve vision loss caused by a stroke. Researchers will use low-intensity focused ultrasound to stimulate brain areas that control sight, combined with virtual reality therapy. The study involves 28 adults who had a stroke 6 to 24 months ago and hav…

This study tests if using augmented reality (AR) games can help people with brain injuries stick with their rehab therapy. Researchers will have 30 adults try the GlenXRose AR program alongside standard care to see if it improves how often they practice and their overall recovery…

This study tests whether adding artificial intelligence-driven virtual reality (VR) therapy to standard rehabilitation helps stroke patients recover arm movement better than standard therapy alone. The trial will include 50 adults recently hospitalized with a stroke who have arm …

This study tests whether adding a gentle brain stimulation technique (tDCS) to a focused arm therapy (Constraint-Induced Therapy) can improve arm and hand movement in people who had a stroke at least six months ago. Forty participants will be split into two groups: one gets both …

This study tests whether watching moving visual patterns (optokinetic stimulation) can help stroke patients who have spatial neglect—a condition where they ignore one side of their body or space. The goal is to see if this simple, non-invasive technique improves balance and aware…

This study looks at whether special breathing exercises can make the diaphragm and chest muscles thicker in people who have had a stroke. About 35 adults aged 18–65 will do the exercises for 4 weeks, with check-ups at 2, 4, and 8 weeks. Researchers will use ultrasound to measure …

This early-phase trial tests whether taking three drugs (Telmisartan, Cilostazol, and Metformin) during robot-assisted arm and hand therapy can help chronic stroke survivors regain more movement. About 50 adults who had a stroke at least six months ago and have moderate to severe…

This study tests whether targeted muscle vibration or whole-arm vibration works better to reduce muscle stiffness and improve arm movement in people who had a stroke 3 to 6 months ago. Fifty-four adults aged 45 to 60 will receive one of the two vibration treatments. The goal is t…

This study tests whether combining two non-invasive brain stimulation techniques (tDCS and TMS) can improve memory, thinking, and movement in people who have had a stroke. Twenty-four participants will receive either real or fake (sham) stimulation daily for a week. Researchers w…

This study aims to create and test a self-rehabilitation program for people who have had a stroke more than 6 months ago. The program is based on everyday activities like dressing or cooking, designed with input from patients. Researchers will see if this approach helps improve m…

This study tests if applying gentle vibration to the bottom of the foot can improve walking speed and balance in people who have had a stroke. Researchers will measure changes using simple walking and balance tests. The goal is to see if this easy, non-invasive method can help st…

This study looks at whether doing simple mental math (like addition or subtraction) right before walking can help stroke survivors move better. About 17 participants will be asked to walk after either doing math or resting. The goal is to see if this "brain warm-up" improves walk…

This study looks at whether doing special exercises along with rhythmic music can improve balance, walking, and quality of life in people who have had a stroke. The researchers will work with 32 adults aged 40 to 60 who have weakness on one side of the body and trouble walking. T…

This study tests whether combining two therapies—blood flow restriction training (using a cuff to partially restrict arm blood flow during exercise) and repetitive transcranial magnetic stimulation (a non-invasive brain stimulation)—can improve arm and leg function in people who …

This study tests whether a virtual reality headset (H'Ability Home) helps stroke survivors improve their independence and walking speed better than traditional paper exercise booklets. About 44 people who have had their first stroke and are finishing in-center rehab will use the …

This study tests a stepped-care program to support relatives of people with serious brain diseases or injuries. 160 relatives will either receive the program or usual care. The goal is to reduce caregiver burden and improve well-being.

This study tests whether adding scalp acupuncture to standard brain stimulation (rTMS) and rehab therapy helps stroke survivors regain arm movement. About 44 adults who had a stroke 1-6 months ago will participate. Researchers will measure brain activity and arm function to see i…

This study tests whether adding a second type of electrical stimulation (NMES) to standard TENS therapy works better for stroke patients with shoulder pain. About 40 adults who had a stroke within the past year and have at least moderate shoulder pain will be randomly assigned to…

This study tests a home-based virtual reality system (MUVITY) to help people who had a stroke 3 to 12 months ago improve their movement and balance. About 322 participants will either get usual rehab instructions or use the VR system, which adapts exercises as they progress. The …

This study tests whether special balance exercises that target the inner ear (vestibular system) can help people who had a stroke walk more safely in their community and reduce their risk of falling. The study will include 40 adults who had a stroke at least 6 months ago and can …

This study tests a new robot-based therapy (ROBUST) to improve arm function in people who had a stroke more than 6 months ago. 109 participants will either receive the robot therapy or standard care. The goal is to see if the robot helps with movement and daily tasks.

This study tests whether a gentle brain stimulation technique called tDCS can be easily added to regular speech therapy for people who have had a stroke and now have aphasia (trouble speaking or understanding language). The study will include 30 stroke survivors in a hospital reh…

This study compares two treatments—neuromuscular electrical stimulation (NMES) and EMG biofeedback—for shoulder subluxation (partial dislocation) in 36 stroke survivors. The goal is to see which therapy better improves shoulder muscle thickness, range of motion, pain, and quality…

This study will compare two physical therapy techniques—pelvic proprioceptive neuromuscular facilitation and multiplanar trunk training—to see which one better improves balance and walking ability in people who have had a stroke. The study plans to enroll 48 adults who are at lea…

This study tests a special training program for the soleus muscle (a calf muscle) to see if it helps people who have had a stroke walk better and improve muscle activity. The study will include 40 adults aged 45-60 who had a stroke and can walk at least 10 meters. Researchers wil…

This study tests whether a chatbot in the Doubao app can help people with depression after a stroke. About 240 participants will use the chatbot to receive positive psychological counseling. The goal is to see if it reduces depressive symptoms and improves quality of life.

This study tests whether a specific type of leg exercise program (called PNF) can improve balance, walking, and daily life in people who have had a stroke. Forty adults who can walk with or without help will be randomly assigned to either the PNF program or standard physical ther…

This study will test a new augmented reality-based mirror therapy system (MirrARm) to help stroke patients recover arm movement and daily function. Thirty adults who had a first stroke 3 to 12 months ago will use the system or standard mirror therapy three times a week for eight …

This study tests a gentle, non-invasive ear stimulation device to help people over 70 improve swallowing after a stroke. Twenty participants will receive either the active device or a sham (inactive) device alongside standard speech therapy for three weeks. Researchers will measu…

This study tests whether listening to music for 30 minutes each day can improve attention, language, and quality of life in people with aphasia (trouble speaking or understanding language) after a stroke. Researchers will compare music listening to audiobook listening and a contr…

This study tests whether combining aromatherapy with transcranial magnetic stimulation (a non-invasive brain stimulation technique) can improve sleep in stroke patients who have insomnia. Six adults aged 24 to 65 with a stroke diagnosis and insomnia will receive the treatment. Th…

This study will see if yoga classes (both online and in-person) are practical and helpful for adults who had a stroke at least three months ago. Forty participants in Nova Scotia will take yoga twice a week for 90 minutes, plus one recorded session. Researchers will measure satis…

This study tests a new virtual reality therapy for people who had a stroke. It compares standard VR mirror therapy to a version that adds focused attention on objects, with or without sound cues. The goal is to see if this approach improves arm movement and brain activity after j…

This study tests whether taking probiotics can improve quality of life, daily activities, and anxiety in people who have had a moderate stroke. About 110 adults aged 18 to 80 will take probiotics and be monitored for changes in how they feel and function. The goal is to see if a …

This study tests whether a treatment called extracorporeal shock wave therapy (ESWT) can reduce leg muscle stiffness and improve walking in people who have had a stroke. About 85 adults who have had a stroke at least 3 months ago and have stiff leg muscles will be randomly assign…

This study tests whether wobble board or Swiss ball exercises are better at improving balance and stability in people who have had a stroke. About 38 adults aged 40 to 60 who had a stroke more than 6 months ago will participate. The goal is to see which exercise method helps redu…

This study tests whether specially adapted shoes can improve walking quality in people who have had a stroke. It includes 58 adults who have leg stiffness and a tip-toeing walk due to stroke. Participants will wear the adapted shoes for 30 days, and researchers will measure chang…

This study tests whether using a GPS-like system (neuronavigation) to guide brain stimulation (rTMS) helps people with arm weakness after a stroke recover better than the standard method. Thirty adults who had a stroke within the last 2 weeks to 6 months will receive 10 sessions …

This study tests whether using an intermittent pneumatic compression device on the leg can improve ankle joint awareness (proprioception) and balance in people who have had a stroke. Fifty-six participants aged 50-65 with moderate balance problems will be measured on how accurate…

This study tests whether augmented reality (AR) can help people who have had a stroke walk with more balanced steps. Twenty adults who had a stroke within the past 6 months will try two types of visual feedback (an avatar or bars) while walking in an AR environment. The goal is t…

This study looks at whether a short, intense workout on a special stepper machine is safe and doable for people recovering from a stroke in the hospital. Researchers will check for side effects, how many people can finish the 10-minute session, and if participants enjoy it. The g…

This study looks at whether the clot-busting drug tenecteplase is safe and effective for people having a stroke who receive it more than 4.5 hours after symptoms began. Researchers will follow 3,000 patients in China to see how well they recover after 90 days. The goal is to gath…

This study looks at how the immune system and inflammation change in people having a stroke who receive clot-busting drugs or mechanical clot removal. Researchers will take blood samples at several time points over a year to measure inflammatory markers. The goal is to see if the…

This study looks at whether a special nurse-led education session right before stroke patients go home helps them stick to their medications and care plan. About 300 patients will take part, with half getting the extra nurse talk and half getting usual care. The goal is to see if…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis caused by stroke or spinal cord injury, compared to healthy volunteers. Researchers will measure tendon stiffness, length, and volume using ultrasound and strength tests. The goal is…

This study will test a new device that combines a brain-computer interface (BCI) with Apple Vision Pro to help people with ALS, traumatic brain injury, spinal cord injury, or stroke communicate. Up to 10 participants will use the system for 3-4 months to see how well it works and…

This study looks at how certain genes may influence stroke risk in 1,000 Brazilian adults. Half have had a stroke, half have not. Researchers will compare their DNA to find genetic differences that might explain why some people have strokes. This is an observational study, not a …

This study tests whether an artificial intelligence system can help therapists set up and adjust robotic arm exercises for people recovering from a stroke. About 100 participants will receive either AI-guided or therapist-guided robotic rehab. The goal is to see if the AI approac…

This study checks if an artificial intelligence (AI) system can accurately score how well stroke patients recover, compared to scores given by trained healthcare workers. About 490 adults with confirmed stroke will participate. The goal is to see if the AI can provide a faster, m…

This study aims to find out if certain substances in the mouth and saliva are linked to stroke. Researchers will compare 120 adults who have had a stroke with healthy volunteers, looking at things like inflammation markers and mouth bacteria. No treatments are given—the goal is s…

This study looks at how tightness in the ankle muscles (plantar flexor spasticity) affects balance, the risk of falling, and daily activities in people who have had a stroke. Researchers will measure muscle stiffness, balance, and mobility in 68 adults aged 45 to 60 who had a str…

This pilot study will test whether automated, personalized coping messages can help stroke survivors increase their physical activity. About 50 adults who had a stroke 3 months to 3 years ago and can walk independently will receive these prompts over 3 months. The main goal is to…

This study tests a community-based program designed to reduce loneliness and social isolation in older adults (60+) living in rural Ecuador. The program includes group activities, peer support, and home coaching. Researchers will measure if it improves heart health, thinking skil…

This study will observe 3,000 stroke patients in China who receive clot-busting medication more than 4.5 hours after their stroke started. The goal is to see how well this late treatment works and how safe it is in everyday hospital settings. Participants must be at least 18 year…

This study looks at how the mood and sleep problems of people caring for stroke patients affect their sense of burden. Researchers will ask 100 caregivers and their stroke patients (ages 18-80) to fill out questionnaires about sleep, anxiety, depression, and the challenges of car…

This study looks at 150 adults having emergency clot removal for a stroke. Researchers will measure substances in the blood that show blood vessel damage and inflammation. The goal is to better understand why some patients recover well and others do not, even when the clot is suc…

This study tests a new recruitment method called the ORDER toolkit, which uses brochures and videos designed with women patients to encourage more women to join stroke research. Researchers will compare this approach to standard recruitment in 1,600 people with stroke or mini-str…

This study looks at how the brain changes and reorganizes after a stroke that causes arm weakness. Researchers will use MRI scans to track brain activity and connections in 30 adults over six months. The goal is to learn why some people recover better than others, which may help …

This study tests whether an artificial intelligence (AI) system can help doctors find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 400 participants will be split into two groups: one gets AI-guided monitoring with wearable devices and…

This study will follow about 12,750 adults and children who have had a stroke (either from a clot or bleeding in the brain). Researchers will collect information from before hospital arrival through recovery and long-term follow-up to understand what treatments work best and how …

This study looks at how well people who have had a stroke can imagine movements (motor imagery) and how that relates to their neglect, arm function, daily activities, and quality of life. Researchers will assess 50 stroke survivors using tests for motor skills, neglect, and image…

This study will check if certain walking and balance tests are reliable for people who have had a stroke at least 6 months ago. Researchers will test 30 participants using a walking questionnaire, a 400-meter walk, a falls confidence scale, and a vision test. The goal is to impro…

This study looks at whether using smart technology during early stroke rehabilitation can improve thinking, daily function, and quality of life. About 200 recent stroke patients will be split into four groups: three will use different interactive rehab devices, and one will recei…

This study looks at when to start physical therapy after a stroke caused by a blocked artery. The goal is to see if waiting until day 3 is safer and helps recovery better than starting earlier. About 50 adults with persistent artery blockages will take part. The findings may guid…

This study looks at how well stroke survivors can move around and how that affects the mental health of the family members who care for them. Researchers will measure the patient's mobility and the caregiver's anxiety, depression, and overall burden. The goal is to understand thi…

This study translates and tests a questionnaire that measures how stroke patients feel about their treatment and daily self-care. Researchers will enroll 170 adults aged 18-80 who have been home for at least a month after a stroke. The goal is to create a reliable Turkish version…

This study tests whether a one-week educational campaign at primary health centers can help adults recognize stroke symptoms and call for emergency help faster. About 350 adults aged 18 and older will take part. The campaign uses simple, clear information to improve how people re…

This study looks at how a device that sends small electrical signals to the leg muscles affects walking in people with stroke, traumatic brain injury, or multiple sclerosis. Researchers will measure walking speed, step length, and balance in 90 adults who have trouble lifting the…

This study aims to validate the Stroke Mimics Score, a tool that uses information collected when a patient arrives at the emergency room to help doctors quickly tell the difference between a real stroke and other conditions that mimic stroke symptoms. Researchers will enroll 1,00…

This study tests whether a gentle, non-invasive brain stimulation method called cTBS can improve attention in adults who, after a stroke, ignore one side of their world. Sixty participants will receive real or fake stimulation to the cerebellum or cerebrum while researchers track…

This study tests whether a robotic hand that moves when you imagine moving it (using brain signals) works better than one that moves automatically. Twenty adults with chronic stroke will try both methods to see which improves hand function and brain activity more. The goal is to …

This study looks at how the sense of touch and vibration can help predict hand recovery in people who have had a stroke. Researchers will test hand movement and feeling using special tools and brain scans. The goal is to better understand which patients will improve their hand de…

This observational study aims to understand why stroke survivors experience muscle fatigue differently. Researchers will compare 120 participants (stroke survivors and healthy volunteers) by measuring brain and leg muscle activity during repeated exercises. The goal is to identif…

This study looks at how much social support adult stroke patients feel they have and whether that affects their life satisfaction and ability to take part in social activities. Researchers will compare stroke survivors to healthy adults. The goal is to better understand the role …

This study explores whether personalized magnetic stimulation can boost thinking skills after a stroke. Researchers will first use brain scans to find the right spot for each person, then test if temporarily disrupting that spot affects task performance. The study includes 10 hea…

This study will follow 500 adults who recently had a stroke to see if their handedness affects how well they regain arm movement. Researchers will measure arm function early on and again after 6 months. The goal is to understand if left-handed people recover better, which could h…

This study tests a new robotic and virtual reality system called NeglectARm 3D to see if it can better measure spatial neglect in people who have had a stroke. Fifteen participants will use the system twice, three weeks apart, while researchers check if it is easy to use and reli…

This study looks at whether stroke patients recover better with separate physical and occupational therapy sessions or with combined therapy from both therapists at the same time. About 567 adults admitted to the hospital for a recent stroke will take part. Researchers will measu…

This study looks at whether people who had a stroke more than 6 months ago and cannot move their fingers can regain that ability. Researchers will use brain stimulation and electrical muscle therapy to see who improves. The goal is to understand which patients are most likely to …

This study checks if a tool called the Hypertonia Assessment Tool (HAT) works well for adults who have had a stroke. The HAT helps doctors tell apart different types of muscle tightness, like spasticity and rigidity, which can guide better therapy. Researchers will test 60 stroke…

This study will test whether a special ultrasound of the brain's blood vessels can help predict how well people recover from a stroke. Researchers will measure blood flow in 50 adults within 24 hours of their stroke and compare it to their recovery over 72 hours. The goal is to f…

This study uses robots and eye-tracking to measure how vision and body awareness (proprioception) affect arm movement after a stroke. Researchers will follow 425 people for six months to understand how these senses interact and how brain damage influences recovery. No new treatme…

This study will look at 2000 adults in the Middle East who have had a stroke to find out how common risk factors like high blood pressure, diabetes, high cholesterol, and smoking are. The goal is to understand how these risks differ from those in Western countries, which could he…

This study looks at a specific type of stroke called Branch Atheromatous Disease (BAD), where a small artery deep in the brain gets blocked. Researchers will compare three treatments: a clot-busting drug (IV thrombolysis), one antiplatelet drug, or two antiplatelet drugs. They wi…

This study tests whether a smartphone app can help adults who have had a stroke with their rehabilitation. The app uses AI to create personalized exercises. Researchers want to see if people can use the app and if it adapts to their needs. 30 participants will use the app daily f…

This study tests a support program to help stroke survivors better manage their health after leaving the hospital. About 140 adults who have had a stroke will take part. Half will get usual care, and the other half will also attend 5 weekly sessions to learn self-management skill…

This study looks at how well people who have had a stroke can walk backward and how that connects to their leg function, sense of joint position, trunk control, and balance. About 30 adults aged 30-85 who had a stroke within the last 3 days to 24 months will be tested using simpl…

This study aims to understand if specific markers on brain scans can better predict which patients with brain hemorrhage face higher risks of death or disability. Researchers will compare scan findings with existing prediction methods in 50 participants. The goal is to improve ri…