Stroke disorder

This study tests whether clot-busting drugs (alteplase or tenecteplase) are safe and effective for stroke patients who have taken a blood thinner (FXa inhibitor) in the last 48 hours. Current guidelines avoid this treatment due to bleeding concerns, but new evidence suggests it m…

Researchers at the University of South Carolina are testing a program that pairs nurses with community health workers to coach adults who have chronic conditions like diabetes, high blood pressure, heart disease, kidney disease, or a prior stroke. Each patient joins with a carepa…

This study tests a drug called sovateltide in 160 people who have had an ischemic stroke (a stroke caused by a blood clot). The goal is to see if the drug helps patients recover better and is safe. Participants receive either the drug or a placebo within 24 hours of their stroke,…

This study is testing whether a device that uses mild electrical pulses to stimulate arm muscles and the tongue can help stroke survivors regain arm movement. Researchers will enroll 288 participants, including stroke patients with arm weakness and healthy controls. The main goal…

This study tests whether combining a gentle brain stimulation technique (tDCS) with exercises that challenge both thinking and walking can improve how stroke survivors handle doing two things at once. Seventy-two participants who had a stroke at least six months ago will receive …

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and then emergency treatment to remove a clot. Some patients develop bleeding in the brain after the procedure, and doctors want to know if starting blood thinners early …

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This Phase 3 trial tests whether sovateltide, a drug that stimulates ETB receptors, can improve recovery after an acute ischemic stroke. About 514 adults aged 18-80 will receive either sovateltide or a placebo alongside standard care. The main goal is to see if more patients achi…

This study tests a drug called DM199 in about 728 people who have had a moderate stroke and cannot get clot-removing treatments. The drug is given through a vein and then as shots under the skin for three weeks. Researchers want to see if it helps patients recover better than a p…

This trial tests whether adding robotic rehabilitation devices to standard physiotherapy can improve arm and leg function in adults with movement problems from stroke, spinal cord injury, traumatic brain injury, or orthopedic surgery. Participants will receive robotic-assisted se…

This trial tests whether a powered leg exoskeleton called ZEPU AI9 can safely and effectively help people with walking difficulties caused by stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will be randomly assigned to receive either exoskeleton-assiste…

This trial tests whether adding a robotic leg-training device (ZEPU-AI5) to standard rehab can safely improve walking, strength, and balance in adults aged 18–60 with lower-limb problems from stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will receive …

This study is testing whether it is safe and effective to perform two heart procedures at the same time in people with atrial fibrillation (AF). The first procedure uses pulsed field ablation to correct the heart's rhythm, and the second closes off a small pouch in the heart to r…

This study tests whether a robotic device called ZEPU-AI3 can safely help people with lower limb weakness from stroke, spinal cord injury, or orthopedic surgery improve their walking. Participants receive either standard rehabilitation alone or standard rehab plus robot-assisted …

This study tests a robotic device called ZEPU-AI1 that helps people with leg weakness practice standing and walking. The trial includes adults aged 19 to 60 who have walking problems from stroke, spinal cord injury, or orthopedic surgery. Half of the participants will use the rob…

This trial tests whether robotic devices that guide arm and leg movements can safely improve strength, coordination, and daily function in adults with movement problems from stroke, spinal cord injury, brain injury, or orthopedic conditions. Participants will use the devices thre…

Researchers compare two imaging strategies for planning left atrial appendage closure in adults with nonvalvular atrial fibrillation. Participants are randomly assigned to have their heart anatomy assessed either by transesophageal echocardiography or by cardiac CT angiography be…

This pilot trial asks whether adding a robotic hand-training device to standard rehabilitation is safe, practical, and helpful for people with arm and hand motor problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic conditions. Participan…

This pilot study tests whether a virtual-reality system controlled by muscle activity can help improve arm and hand movement in people recovering from stroke or spinal cord injury. Participants use a wearable device that detects muscle signals through sensors on the skin and prov…

This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking antico…

This study looks at whether a cardiac rehabilitation program can improve recovery for people who have had a stroke. Researchers will enroll 150 stroke survivors and add cardiac rehab to their usual care. They will measure walking ability, daily function, and whether the program r…

Researchers in Belo Horizonte, Brazil, are testing iVIDAVC, a behavior-change program adapted from an Irish model, to help stroke survivors adopt healthier habits. The program combines an educational session, one-on-one coaching, and weekly group meetings led by a physiotherapist…

This trial tests whether anisodine hydrobromide can reduce brain damage in people who have had a severe ischemic stroke and are undergoing a procedure to remove the blood clot. The study includes about 200 adults aged 18 to 80 with a blockage in a major artery in the front of the…

This study tests whether a laptop-based memory training program can help people who had a stroke more than a year ago improve their ability to learn and remember new information. Participants will complete memory exercises twice a week for five weeks. Researchers will measure cha…

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This study looks at whether starting insulin to lower high blood sugar on day 4 after a severe stroke is better than starting on day 1. About 200 adults with severe stroke and high blood sugar will be randomly assigned to early or delayed treatment. The goal is to see if delaying…

This study tests a 3-month home program for people aged 50+ who recently had a stroke and are returning home. The program combines guided stepping training with tips to reduce long periods of sitting. Researchers measure changes in daily steps, mobility, and disability over 12 mo…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This study tests whether taking stroke patients directly to a special imaging and treatment room (angio suite) speeds up care compared to the usual approach of getting a CT or MRI first. About 594 adults with severe stroke symptoms will be randomly assigned to one of the two path…

This trial tests whether task-specific drawing exercises can improve hand dexterity and motor function in people recovering from a stroke, compared with standard fine motor training. Adults aged 40 to 70 with subacute stroke will be randomly assigned to one of two four-week progr…

This trial tests whether the amount of therapist supervision during home-based telerehabilitation changes arm recovery in stroke survivors. Researchers will enroll 30 adults aged 40 to 70 with mild to moderate arm impairment and randomly assign them to either three videoconferenc…

This study tests whether giving a strong cholesterol-lowering drug (PCSK9 inhibitor) before emergency stroke treatment helps people recover better. About 652 adults with a major stroke will be randomly assigned to receive either the intensive drug or standard care. The main goal …

This study looks at whether removing a large blood clot from the brain (endovascular thrombectomy) is better than standard medical care for stroke patients who already had a moderate-to-severe disability before their stroke. About 1,060 adults with a recent stroke and a pre-exist…

This study tests whether giving stroke patients a personalized diet plan within two days can lower the risk of death within 30 days. About 3,084 adults with moderate to severe stroke will take part. Dietitians will track food intake and adjust nutrition, using supplements or tube…

This trial tests a digital tongue-pressure training device that gives real-time feedback to help stroke survivors with swallowing problems, a condition called dysphagia. The device measures tongue strength in different areas and guides users through exercises. Researchers will co…

This trial tests whether adding mirror therapy to standard rehabilitation improves walking and leg function in people who had a stroke. Participants are adults aged 40 to 70 who had their first stroke 3 to 6 months ago and can walk at least 10 meters. Half will receive convention…

This study tests whether a robot can help people who had a stroke 1 to 12 months ago improve movement and feeling in their arm and hand. Participants first receive gentle, robot-guided stretching, then practice active movements with the robot, which can assist or resist as needed…

This study tests a 16-week home-based physiotherapy programme for people who have recently had a stroke. The programme combines in-person and remote sessions, an online exercise platform, and goal-setting to help participants do more rehabilitation. Researchers will see if this a…

This phase 2 trial tests whether the drug J147, given by IV after clot removal, helps people recover from an acute ischemic stroke. About 196 participants will receive either J147 or a placebo. Researchers will measure brain function and safety through MRI scans and blood tests o…

This study tests whether implanting small filters in the carotid arteries (the main neck arteries) can prevent repeat strokes in people with atrial fibrillation who have already had a stroke. Participants will receive the filters plus standard blood thinners, or blood thinners al…

This trial tests whether a computer-based rehabilitation system called NeuroTechR3 can help people improve arm and hand function after a stroke. Participants will play upper extremity rehabilitation games on a computer for 30 minutes, three times a week. The study measures change…

This trial tests whether placing a stent in a narrowed or blocked neck artery during emergency stroke treatment helps people recover better than just removing the clot in the brain. About 15-20% of severe strokes involve both a brain clot and a neck artery blockage. The study wil…

This study looks at whether successfully restoring blood flow in the brain using the Tigertriever device, a tool that removes clots during a stroke, may also help protect cognitive abilities like memory and attention. Researchers will follow 424 adults aged 18 to 75 who had a lar…

This trial tests whether adding metacognitive training—exercises that help people think about their own thinking—to standard word-finding rehabilitation can improve language skills in people with chronic aphasia after a stroke. The study involves 18 participants who will receive …

This trial tests whether adding self-administered hand therapy at home, using a videogame controller called the Twirlstone, can improve hand dexterity and coordination in stroke survivors. Participants, who are within six weeks of a stroke and have arm or hand weakness, will eith…

This study compares two procedures used to treat unruptured wide-neck brain aneurysms: flow diverter stents and stent-assisted coiling. Researchers will follow 274 adults from three centers in China who receive one of these treatments as part of routine care. The main question is…

This study tests a new device and technique (ADAPT 2.0) for removing blood clots in people having an acute ischemic stroke. The goal is to see if it can restore blood flow more completely and safely than current methods. About 750 adults who are already scheduled for clot removal…

This study tests whether the drug clevidipine can lower blood pressure quickly and steadily in people having a bleeding stroke (intracerebral hemorrhage). High blood pressure can make the bleeding worse, so getting it under control fast is critical. The trial will compare clevidi…

This trial investigates whether combining repetitive transcranial magnetic stimulation (rTMS) with aerobic exercise can treat depression and improve walking in people who have had a stroke. Participants will receive either real or sham rTMS along with exercise sessions over 12 we…

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This trial compares two rehabilitation approaches—neurodevelopmental technique (NDT) and mirror therapy—to see which better improves coordination, leg function, and walking ability in people recovering from a sub-acute stroke. Forty adults aged 45 to 65 with hemiplegia (weakness …

This trial is testing whether vitamin D supplements can improve bone density, body composition, strength, walking speed, and physical performance in people hospitalized with neurological disorders like stroke, spinal cord injury, or traumatic brain injury. Participants will recei…

This trial investigates whether a procedure to remove blood clots from arteries in the back of the brain can improve recovery in people who had a stroke more than 24 hours ago but within the last 7 days. Participants will either receive standard medication alone or the clot-remov…

This trial tests whether flushing a stent-graft with carbon dioxide before implanting it in the aorta can reduce the number of tiny air bubbles that travel to the brain during the procedure. These bubbles are a major cause of stroke and silent brain damage in patients undergoing …

This large trial compares robot-assisted rehabilitation to traditional one-on-one physiotherapy for people who have had a stroke. Researchers are measuring how well each approach helps patients regain independence in daily activities, as well as costs and patient satisfaction. Th…

This trial tests whether a structured arm therapy program delivered through video calls can improve upper limb function in people who had a stroke at least six months ago, compared with the same therapy given in a clinic. Sixty-eight participants will receive modified Constraint-…

This trial tests whether adding electrical muscle stimulation to a standard motor relearning program improves arm function more than the program alone in people recovering from a subacute stroke. Thirty-six participants will receive either the combined therapy or the program only…

This trial investigates an unapproved medical device designed to help control a specific disease. Participants receive the device to see if it can reduce symptoms or manage the condition. The study focuses on safety and effectiveness in people with the disease.

This study tests whether deep brain stimulation (DBS) combined with physical therapy can improve arm weakness in people who had a stroke 1 to 6 years ago. About 202 participants will receive either DBS plus rehab or rehab alone. The goal is to see if the treatment safely restores…

This trial tests whether apixaban, a newer blood thinner with fixed dosing, works as well as warfarin for dissolving dangerous blood clots in the heart's main pumping chamber. Adults with a confirmed left ventricular thrombus are randomly assigned to receive either apixaban or wa…

This trial compares two strategies to prevent another stroke in people with severe narrowing of a major brain artery. One group receives a drug-eluting stent (a mesh tube that releases medication to keep the artery open) along with aggressive blood-thinning medication. The other …

This study investigates whether a personalized, technology-based rehabilitation program can improve arm movement and function in people who have had a stroke. Participants will receive the technology-enhanced therapy three times a week for about a month, alongside standard care. …

This trial tests a new device called the P3 Occluder System designed to close a patent foramen ovale (PFO) — a small opening between the upper chambers of the heart. The study includes adults aged 18 to 65 who have had a stroke possibly linked to a PFO. Participants receive the i…

This study tests a surgically implanted device that uses mild electrical pulses to stimulate muscles in the legs and trunk. The goal is to help people with paralysis from spinal cord injury, stroke, or other conditions exercise, stand, step, and improve balance. Ten participants …

This trial investigates whether two medications—colchicine (an anti-inflammatory) and deferoxamine (an iron chelator)—can prevent further brain injury after a hemorrhagic stroke. Up to 2,000 adults aged 18–80 with a spontaneous brain bleed will receive one of four treatments: sta…

This study investigates whether adding neuromuscular electrical stimulation (NMES) to reactive balance training helps people who have had a stroke recover more effectively from slips and trips. Participants, who are at least six months post-stroke and able to walk on a treadmill,…

This study tests a wireless brain-computer interface implanted in the skull to help people who had a stroke regain arm movement. Ten participants will undergo intensive rehabilitation with and without the device. The main goal is to check safety, but researchers will also measure…

This study tests whether starting a special exercise program soon after a stroke can protect the brain from memory loss and dementia. Researchers will enroll 120 people who had a stroke in the past 6 months. Participants will do a mix of exercises, and the study will measure chan…

This early-stage trial tests a new drug called SNE-101 in people who have had an acute ischemic stroke within the past five days. The main goal is to see if SNE-101 is safe and tolerable, and to find the highest safe dose. The study also looks at whether SNE-101 can improve motor…

This study tests a new device called the RapidPulse Aspiration System, which uses precisely timed suction to remove blood clots from brain arteries in people having a severe stroke. The trial will enroll 170 adults aged 18 to 80 who can be treated within 8 hours of stroke symptom…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This study looks at whether adding a blood thinner to standard antiplatelet therapy helps prevent strokes and blood clots in people who develop a new, temporary irregular heartbeat after coronary artery bypass surgery. About 3,200 adults who had bypass surgery and then experience…

This study tests whether adding GM1, a natural brain substance, to standard clot-removal treatment helps people recover better after a severe stroke. About 868 adults in China who have a blocked artery in the front part of the brain will receive either GM1 or a placebo daily for …

This study compares a new 'virtual stroke unit' approach to standard stroke unit care for people with a stroke who are not eligible for a clot removal procedure. The virtual unit uses video calls and monitoring equipment to let a specialist team at a main hospital help guide care…

This study compares two blood thinner strategies after left atrial appendage closure (LAAC) in people with atrial fibrillation. Sixty participants will receive either aspirin alone or aspirin plus clopidogrel for three months. The goal is to see which approach better prevents sma…

This study tests whether the Luna EMG rehabilitation robot can help people who had a stroke more than a year ago improve arm movement. Five participants will use the robot for 30 minutes per session as part of their rehab. The goal is to see if the robot can make arm movements sm…

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with chronic stroke move their arms and legs again. Only 3 participants will be implanted with electrodes on the brain and spine. The main goal is to check safety, but researche…

This study compares two treatment strategies for elderly frail patients with atrial fibrillation (AF) who are at high risk for both stroke and bleeding. One group receives catheter ablation plus a device to close the left atrial appendage (LAAO), while the other receives ablation…

This study tests a nurse-led program called BEST CARE ICTUS_HC for adults hospitalized with acute stroke in hospitals without specialized stroke units. The program includes staff training, swallowing tests, and environmental adaptations to help with attention and safety. Research…

This study looks at people over 65 who recently had a stroke with no clear cause. Doctors suspect they may have hidden atrial fibrillation (an irregular heartbeat) not caught in the hospital. The trial compares two treatments: a blood thinner (apixaban) or aspirin, to see which b…

This study tests whether Diroximel Fumarate, a drug already used for multiple sclerosis, can reduce harmful brain swelling that often occurs after a hemorrhagic stroke. The swelling, called perihematomal edema, can worsen recovery. The trial will enroll 192 adults who have had a …

This study tests whether a structured care bundle—including rapid blood pressure control, reversal of blood thinners, and management of fever and blood sugar—can improve outcomes for people with a brain bleed. About 3500 adults in Sweden and Australia will receive either the care…

This study tests whether low-intensity focused ultrasound (tFUS) can help people with severe traumatic brain injury who have not fully recovered consciousness. Researchers will compare real tFUS to a sham (fake) treatment in 60 participants, measuring changes in consciousness usi…

This study tests whether placing a stent in the brain artery after removing a clot can improve recovery for people having a severe stroke. About 342 adults aged 18-80 with a blocked large artery and significant residual narrowing will be randomly assigned to get either standard c…

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and researchers…

This study looks at whether a 15-week lifestyle program combining weight management and exercise can improve walking and daily function in obese veterans who had a stroke at least six months ago. Researchers will measure changes in walking distance, daily steps, and overall recov…

This study tests a new decision-making tool called IMPROVE that uses MRI scans to detect unstable plaques in the carotid artery. The goal is to see if this method is at least as good as the current standard (which mainly looks at how narrow the artery is) for selecting which pati…

This study compares two medicines—apixaban (a blood thinner) and aspirin—in people who have had a brain bleed (intracerebral hemorrhage) and also have an irregular heartbeat (atrial fibrillation). The goal is to see which drug better prevents future strokes or death. About 700 pa…

This study is testing a device that sends mild electrical pulses to the vagus nerve in the neck, paired with physical therapy, to help people who had a stroke months or years ago. The goal is to see if this approach can safely improve arm and leg movement. About 40 adults with ch…

This study looks at how well and how safely the Tigertriever device works to remove blood clots from large brain vessels in people having an ischemic stroke. About 150 adults will be treated within 8 hours of their first symptoms. The goal is to restore blood flow and improve rec…

This trial is testing a drug called tenecteplase for people with a severe stroke caused by a blockage in the basilar artery at the back of the brain. About 688 participants will receive either tenecteplase or standard care within 24 hours of symptoms starting, followed by a clot-…

This study tests whether a balloon angioplasty procedure can prevent early neurological decline in people who have had a minor stroke due to a narrowed brain artery. The trial will enroll 100 adults who have already received standard medication but still show fluctuating or worse…

This study tests if briefly stopping and restarting blood flow in the neck after a stroke procedure can help the brain heal better. About 120 adults who had a major stroke and received emergency treatment to reopen a blocked artery will be randomly assigned to get this extra ther…

This study tests whether a smart glove can help people with brain disorders (like stroke or brain injury) improve arm and hand function from home. Forty adults with lasting arm weakness will either use the smart glove for guided exercises or do standard home therapy. The goal is …

This international study tests whether a robotic exoskeleton (Gloreha Sinfonia) combined with standard therapy can improve arm function in people who recently had a stroke. 130 participants will be randomly assigned to either robotic therapy plus standard care or standard care al…

This early study tests a brain-computer implant that reads brain signals to help people with severe paralysis (from ALS, stroke, or spinal cord injury) communicate. The device aims to decode imagined speech and allow control of computers. Only 2 participants will be enrolled to c…

This study looks at 180 adults with moderate to severe narrowing of brain arteries who have high LDL cholesterol. Researchers want to see if improving cholesterol management can lower the chance of having a stroke. Participants will not receive any experimental treatment; instead…

This study tests whether using remote-controlled CT scans at local medical centers, guided by a hospital stroke team via video call, can speed up treatment for stroke patients. About 52 participants with suspected stroke will be randomly assigned to either this new approach or st…

This study looks at whether a structured weight loss program, with or without added exercise, can improve physical function and emotional well-being in obese veterans who have had a stroke. Researchers will enroll 130 participants aged 35-85 who had a stroke at least 6 months ago…

This study tests whether a newer clot-dissolving drug (tenecteplase) works better than the standard drug (alteplase) when given before a mechanical procedure to remove a large blood clot from the brain. About 850 adults who have had a severe stroke within the last 4.5 hours will …

This study tests whether a team of community health workers, social workers, and nurses can help stroke survivors who face social challenges like food or housing insecurity. The team visits participants at home starting within 72 hours of hospital discharge, offering referrals, c…

This study tests whether the clot-busting drug tenecteplase can help people who have had a stroke 24 to 72 hours earlier. Currently, such drugs are only given within a few hours. The trial will compare tenecteplase to standard care (blood thinners) in 330 adults with blocked brai…

This study tests whether a home hospitalization program (NORA-HOME) is safe and effective for people who have had a minor stroke or transient ischemic attack (TIA). Researchers will compare home monitoring with standard hospital care in 250 participants. The goal is to see if hom…

This study tests whether closing a small hole in the heart (called a PFO) plus medication is better than medication alone at preventing repeat strokes in people over 60 who have had a cryptogenic stroke (a stroke with no clear cause). About 714 participants will be randomly assig…

This study tests whether a daily low dose of colchicine, an anti-inflammatory drug, can prevent heart attacks, strokes, and severe leg complications in people with peripheral artery disease (PAD). About 6,150 participants with symptomatic PAD will receive either colchicine or a p…

This study tests a new device that uses stitches to close a small hole in the heart (called PFO) in people who have had a stroke. It compares the stitch method to a standard metal plug device. About 640 adults aged 18-60 with a PFO and a recent stroke will be enrolled. The goal i…

This study looks at two ways to prevent another stroke in older adults who have a hole in the heart (PFO) and had a stroke from an unknown cause. One option is a procedure to close the hole, plus lifelong blood thinners. The other is taking blood thinners alone. Researchers will …

This study tests whether freezing specific nerves (cryoneurolysis) can reduce shoulder pain and improve movement in people with spasticity from conditions like stroke or brain injury. Fifty adults will either receive one session of nerve freezing or one session of Botox injection…

This study tests whether taking stroke patients straight to the angiography suite for clot removal, instead of first evaluating them in the emergency department, leads to better recovery. About 2,000 adults with severe stroke symptoms within 7 hours will be randomly assigned to o…

This study tests whether a high-dose, high-intensity neurorehabilitation program using digital devices (MindMotion GO, Izar) is feasible for stroke patients. 120 adults with stroke will train about one hour per day, five days a week, across inpatient and home settings. The goal i…

This study looks at the best blood-thinning medicine after a minimally invasive heart valve repair for mitral regurgitation, a common heart condition. About 1,032 participants will be randomly assigned to take either aspirin alone or aspirin plus clopidogrel. The goal is to see w…

This study looks at 880 people who had a minimally invasive heart valve repair and also need long-term blood thinners. It compares taking just one blood thinner (rivaroxaban) versus taking two (rivaroxaban plus clopidogrel) to see which causes fewer bleeding problems over one yea…

This study tests whether performing carotid artery surgery within 72 hours of a mini-stroke or minor stroke is safer and more effective than waiting 4 to 15 days. About 456 participants with a blocked neck artery will be randomly assigned to one of two timing groups. The goal is …

This study tests whether removing a blood clot from a smaller brain vessel (distal medium vessel) using a catheter-based procedure helps people recover better from a stroke than standard medical therapy alone. About 584 adults who had a stroke within the last 12 hours and cannot …

This study looks at whether giving clot-busting drugs to stroke patients who are already on blood thinners is safe and effective. About 260 adults who had a stroke while taking common blood thinners will be enrolled. The goal is to see if this treatment can improve recovery witho…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study tests a new device called the iNstroke 4F catheter, designed to remove blood clots from small blood vessels deep in the brain after a stroke. About 57 adults who have had a stroke within the past 24 hours will receive this treatment. The goal is to see if the catheter …

This study tests whether giving the clot-busting drug tenecteplase directly into the brain artery after mechanical clot removal can improve outcomes for people with acute ischemic stroke. About 132 adults aged 18-85 with large vessel blockages will be randomly assigned to receive…

This trial tests whether doing brain scans and clot-removal procedures in the same room speeds up treatment for severe strokes. About 390 patients with suspected large-vessel blockages will be randomly assigned to either the usual two-room process or a one-room approach. The goal…

This study tests a weight-loss program delivered via telehealth for people who have had a stroke. The goal is to help participants lose weight and improve their health, especially those in underserved communities. The study will compare the program to a wait-list control group an…

This study tests whether bringing blood pressure down very quickly (below 120 mmHg) after a stroke clot removal procedure improves recovery. About 910 stroke patients will be randomly assigned to either intensive or standard blood pressure management. The goal is to see if this a…

This study tests a new way to manage blood pressure in people having a stroke who receive clot-busting medication. The goal is to see if adjusting blood pressure treatment can lower the risk of bleeding in the brain. About 340 participants will be randomly assigned to either the …

This study tests a device called AtriLASH that closes a small heart pouch (the left atrial appendage) during planned heart surgery in 200 people with atrial fibrillation. The goal is to prevent blood clots that cause strokes, potentially reducing the need for blood-thinning medic…

This study tests whether blood thinners (NOACs) can prevent stroke in people who develop atrial fibrillation only during stressful events like surgery or serious illness. About 2,270 participants will be randomly assigned to take a blood thinner or not, and researchers will track…

This study compares two types of general anesthesia during emergency clot removal for stroke patients. The goal is to see which method better maintains blood flow to the brain and improves recovery. About 90 adults with severe stroke will take part at two hospitals in Los Angeles…

This Phase 3 trial tests whether adding carotid artery stenting to standard mechanical clot removal improves recovery in people with acute ischemic stroke caused by a blockage in the internal carotid artery. About 404 participants aged 18-79 will be randomly assigned to receive e…

This study tests whether common stroke-preventing medications—aspirin, clopidogrel, and statins—can reduce the risk of future stroke, heart attack, and dementia in people who have small, symptomless areas of brain damage called covert brain infarcts (CBIs). These are often found …

This study tests a new drug called TBO-309, which helps prevent blood clots, in people having a stroke. It is given alongside standard treatments like clot-busting drugs or mechanical clot removal. The main goal is to see if it is safe, especially regarding bleeding in the brain,…

This study tests whether adding high-dose steroids to standard aspirin treatment helps children recover better from a stroke caused by inflamed brain arteries. About 70 children aged 6 months to 18 years will be randomly assigned to receive either steroids plus aspirin or aspirin…

This global study tests whether a procedure that removes blood clots from the brain can safely help stroke patients treated up to 72 hours after symptoms start, using only a basic CT scan that is available in most hospitals. Currently, this treatment is only proven within 6 hours…

This study looks at whether an over-the-counter supplement called MitoQ and a technique called ischemic conditioning (using a blood pressure cuff to briefly restrict blood flow) can improve blood vessel function in people who have had a stroke. About 30 stroke survivors will take…

Researchers test whether a portable low-field MRI scanner in the emergency department can help diagnose ischemic stroke faster and guide treatment. The trial enrolls 60 adults who arrive within 6 hours of stroke symptoms and are eligible for clot-busting drugs or clot removal. By…

Researchers are testing whether a radioactive tracer called 18F-DPA714 can help PET/CT scans spot inflammation in the brain. The study includes adults with conditions linked to brain inflammation, such as stroke and neurodegenerative diseases. Each participant receives one inject…

This pilot study tests whether a special PET scan using a tracer called Florbetaben can detect inflamed plaque in arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method can identify unstable plaques that are likely to…

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This study evaluates a portable, low-field MRI device (Hyperfine Swoop) for diagnosing stroke in people arriving at the emergency department with symptoms lasting less than 12 hours. Participants receive the low-field scan in addition to standard CT imaging. The goal is to see if…

This trial tests a wearable bracelet called Stroke Alarm that detects when a stroke causes arm weakness. People aged 50 and older with certain high-risk conditions (like recent mini-stroke, atrial fibrillation, or artery disease) wear the device for 3 months. The goal is to see i…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This study compares a new wireless heart sensor patch to standard hospital monitoring for detecting atrial fibrillation (an irregular heartbeat) in people who recently had a stroke. About 450 adults will be randomly assigned to wear the patch for up to 14 days or receive usual ca…

This study aims to create a rapid blood test that can tell if a stroke is caused by bleeding or a clot, using a protein called GFAP. Researchers will test this in 527 adults with suspected stroke at the hospital. The goal is to help doctors start the right treatment faster, espec…

This study is testing whether a simple ultrasound of the optic nerve can quickly detect brain swelling and inflammation in ICU patients with conditions like meningitis, encephalitis, or stroke. Researchers will measure the optic nerve sheath diameter in 200 adults and compare it …

Researchers are testing whether primary care clinics can prevent heart attacks and strokes by automatically calculating each patient's cardiovascular risk and sending monthly text messages with advice to those at high risk. The trial enrolls about 22,000 adults aged 40 to 79 in Y…

This large study tests whether a smartphone app can help prevent strokes by detecting atrial fibrillation (an irregular heartbeat) early. Adults aged 65 and older in Austria are randomly assigned to use the 'Pulskontrolle' app for pulse checks or to receive usual care. If the app…

This study tests a special therapy for stroke patients in the hospital to help them avoid falls after they go home. Falls are common after a stroke and can cause injuries or fear of falling. The therapy includes extra exercises and education about fall risks. Researchers will tra…

This large study in Denmark is testing whether the shingles vaccine (Shingrix) can do more than prevent shingles—it may also lower the risk of heart attacks, strokes, and dementia. About 162,000 adults aged 65 and older will either get the vaccine or no vaccine, and researchers w…

This study tests whether five weekly video therapy sessions led by trained non-professional counselors can prevent depression in older, low-income stroke survivors who have mild depressive symptoms. Researchers will track 350 participants for up to three months to see if the prog…

This study tests whether hydroxyurea, a drug already used for sickle cell disease, can prevent strokes in 220 high-risk children in Nigeria. Children with sickle cell anemia and abnormal blood flow in the brain will receive low then moderate doses of hydroxyurea. The goal is to s…

This study tests whether a low dose (81 mg) of daily aspirin works as well as a higher dose (325 mg) to prevent strokes in people who have injured blood vessels in their neck or head. About 98 adults with blunt cerebrovascular injury will be randomly assigned to one of the two do…

This study looks at whether closing a small pouch in the heart (the left atrial appendage) during open-heart surgery can help prevent strokes in people with atrial fibrillation. Researchers will analyze heart tissue, blood, and ECG recordings from 1000 participants to find out wh…

This trial tests whether spinal cord stimulation (SCS) can reduce muscle spasticity in adults who have had a stroke. Participants will have a small device implanted that sends electrical pulses to the spinal cord. Half will receive active stimulation for six weeks, while the othe…

This study tests whether high-intensity interval training (HIIT) on a recumbent stepper can improve muscle power in people who have had a stroke. 66 chronic stroke survivors aged 50-80 will be randomly assigned to HIIT, moderate-intensity continuous training, or stretching for 12…

This study tests whether a personalized form of brain stimulation (tDCS) can help people who had a stroke more than 3 months ago regain arm movement. Researchers will use brain scans to tailor the stimulation to each person and measure changes in brain connectivity and motor func…

This study looks at whether adjusting deep brain stimulation (DBS) can improve movement, speech, and swallowing in people already implanted with DBS for conditions like tremor, stroke, or traumatic brain injury. Researchers will test hand dexterity, grip strength, facial movement…

Researchers are testing whether MLC901 (NeuroAiD II), a natural capsule, helps people recover after a mild to moderate ischemic stroke. The trial enrolls 80 adults aged 18 to 80 who are within 2 to 10 days of their stroke. Participants receive either MLC901 plus standard stroke c…

Researchers are testing whether transcranial direct current stimulation, a gentle electrical current applied to the scalp, combined with a cognitive behavioural programme can reduce fatigue in people who have had a stroke. The trial enrolls 75 adults who had a stroke at least six…

People who lose arm and hand function after stroke or injury often need more therapy than clinics can provide. Researchers are studying ReHandyBot, a robotic device that guides hand and forearm exercises using virtual reality and touch feedback. The trial checks whether patients …

After a stroke, some people develop unilateral spatial neglect, where they ignore one side of their body or surroundings. Researchers are testing whether an immersive virtual reality program that involves playing a virtual piano can improve this condition. Adults with stroke and …

This pilot study tests whether a device called IVS3 is tolerable and easy to use for arm recovery in people who had a stroke at least 6 months ago. The device uses mirrored video to create the illusion that the affected arm is moving. Researchers will track how many sessions part…

This study tests whether forced aerobic exercise (using a bike that helps move your legs) can improve arm and leg recovery after a stroke better than traditional therapy. About 66 people who had a stroke 3-9 months ago will take part. Researchers will also check if this approach …

This pilot trial tests whether a home-based, technology-supported hand training program can improve hand function in adults who had a stroke at least six months ago. Participants receive either remotely guided hand activities via video conferencing or a standard home exercise pam…

Researchers are testing whether combining transcranial random noise stimulation (tRNS) with neurofeedback can improve attention in adults who have sustained a brain injury from stroke, trauma, or lack of oxygen. Participants receive sessions that pair 10 minutes of tRNS with 20 m…

This study tests a treatment called repetitive transcranial magnetic stimulation (rTMS) for people who have had a stroke more than six months ago and still feel very tired. Fatigue is a common problem after a stroke that can make daily activities hard. The researchers will give r…

Researchers at the University of South Florida are testing whether stroke survivors with chronic aphasia can improve their spontaneous speech by listening to recordings of themselves and correcting mistakes. Participants complete language tasks and then use tablets and headphones…

Researchers at Georgetown University are testing whether a mild electrical brain stimulation called transcranial random noise stimulation (tRNS) can boost the effects of visual training in people who have lost part of their vision from brain damage. The study includes 30 adults w…

This study tests a wearable sensor that tracks neck muscle activity during swallowing exercises, providing real-time feedback to patients. Researchers want to see if adding this device to standard therapy improves swallowing more than therapy alone. The study includes 120 adults …

This study tests whether a small, wearable device that stimulates the ear with mild electricity can reduce long-term pain after a stroke. Researchers will enroll 24 adults who have had a stroke at least 6 months ago and still have pain in their upper arm. Participants will use th…

This study tests whether a home-based telerehabilitation program, using games, exercises, and video calls with therapists, can improve arm function and reduce disability in people who had a stroke 90-150 days ago. 202 participants will be randomly assigned to receive telerehabili…

This study tests a new behavioral therapy called PICTURE IT, delivered via telemedicine, to help people with aphasia after a stroke. The therapy uses pictures and spoken words to stimulate the right side of the brain, aiming to improve language skills. Researchers will compare it…

This study tests a system called STRIVE, which turns a hospital room TV into a motion-tracking gaming console for stroke patients. Using a camera and laptop, it tracks arm and hand movements during games that involve reaching and grasping, without needing controllers or wearable …

This study tests whether a tongue endurance exercise program can improve swallowing in adults who have had a stroke. Seventy participants will be randomly assigned to either the tongue exercise group or a sham therapy group. They will do home-based exercises for 8 weeks and have …

This pilot study tests whether the Voiceitt app can help people with speech impairments caused by conditions like cerebral palsy, stroke, ALS, or Parkinson's disease communicate more effectively. Participants use the app to see if it improves speech clarity and daily communicatio…

This study tests whether combining a gentle brain stimulation technique (tDCS) with repetitive arm and hand exercises can help people who have neglect after a stroke. Neglect means they have trouble paying attention to one side of their body or space. The study also aims to combi…

This study looks at whether yoga is a practical and helpful activity for adults who have had a stroke at least three months ago. Forty participants in Nova Scotia will try both virtual and in-person yoga classes twice a week for 90 minutes, plus one recorded session. Researchers …

This study tests whether escitalopram (Lexapro), a common antidepressant, combined with computer-based naming therapy can improve language recovery in people with aphasia after a stroke. About 88 participants who had a left-hemisphere stroke within the past 5 days will receive ei…

This early study tests a 14-day course of the oral drug zuranolone in 6 stroke survivors with moderate to severe depression. Researchers want to see if the drug is safe, well-tolerated, and improves mood. Participants take 50 mg daily and complete mood questionnaires and blood te…

This study tests whether whole-body vibration therapy, given after a Botox injection, can reduce muscle tightness and improve balance in stroke survivors. Fifty participants with ankle spasticity will either receive vibration or a placebo for 4 weeks. Researchers will measure cha…

This clinical trial investigates whether photobiomodulation, a non-invasive light therapy, can reduce muscle spasticity in adults who have had a stroke. About 42 participants with spastic hemiparesis will receive either active light therapy or a placebo treatment on their calf mu…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. About 48 participants will receive hypnosis sessions alongside standard care, while researchers monitor brain activity with …

This study tests whether extra support—like personalized mask fitting, monthly phone calls, and a tracking app—helps stroke patients with sleep apnea use their CPAP machine more consistently during rehab. About 250 participants will be randomly assigned to either this intensive s…

This trial tests whether Occupational Performance Coaching (OPC) can help adults who have had a stroke and finished rehabilitation get back to activities they value. Participants are randomly assigned to receive OPC or an attention control, both delivered virtually. The study mea…

This study tests whether adding a mild brain stimulation technique (tDCS) to a standard arm therapy (constraint-induced therapy) helps people who had a stroke more than therapy alone. Forty adults with chronic stroke and mild-to-moderate arm weakness will be randomly assigned to …

This study tests whether a digital program called Sleepio, which uses cognitive behavioral therapy for insomnia, can improve sleep in stroke survivors. Researchers will also see if better sleep helps with learning motor skills overnight. About 100 adults who have had a stroke and…

This study tests whether a gentle electrical current applied to the scalp (tDCS) combined with computer-based cognitive training can improve memory, attention, and thinking in people who had a mild stroke. About 60 participants will receive either real tDCS or a sham (fake) versi…

This phase 2 trial tests whether an oral drug called BMS-986368 can reduce spasticity—muscle tightness and spasms—in adults who had a stroke 4 to 18 months ago. The drug works by boosting natural compounds in the body that calm overactive nerves. Researchers will measure changes …

This pilot study tests whether watching special videos can help people recover leg movement after a stroke. Twelve participants will use a video system that shows their good leg moving, while they try to copy the movement with their affected leg. They will do this 5 times a week …

This study tests whether a precise form of brain stimulation (TMS) combined with language therapy can improve word-finding in people who have aphasia after a stroke. Fifty stroke survivors will receive either targeted or control stimulation during therapy sessions. The goal is to…

This study looks at a device called Phagenyx that uses mild electrical pulses to stimulate the throat muscles in stroke survivors who have severe trouble swallowing. Researchers will compare patients who received this treatment with those who did not, to see if it helps them eat …

This study tests whether adding music-like sounds (sonification) to standard walking rehabilitation can improve gait, balance, and quality of life. 120 adults with Parkinson's disease, stroke, or multiple sclerosis will be randomly assigned to standard rehab or rehab with sonific…

This study tests a wearable neuroprosthesis that uses mild electrical stimulation to help stroke survivors open their hand. Two participants will use the device at home for one year to see if it improves daily activities and quality of life. The goal is to understand how well the…

This study tests a wearable robotic knee device (AKO-R) to help people who have had a stroke walk more symmetrically. Twenty participants will do treadmill and overground walking with the device. Researchers will check safety and measure improvements in step length and stance tim…

This study tests whether adding immersive virtual reality (VR) to robotic walking rehabilitation is tolerable for people who cannot walk after a stroke. Thirty non-walking stroke patients will try both standard robotic rehab and VR-enhanced sessions. Researchers will measure moti…

This study looks at whether adding a modified form of cognitive behavioral therapy (a type of talk therapy) to standard occupational or speech therapy can improve emotional well-being and daily functioning in stroke survivors. The trial will enroll 80 adults who had a stroke at l…

This study looks at urinary problems in people recovering from a stroke. Researchers compare patients with and without bladder issues and test two simple behavioral approaches: for those with thinking difficulties, training to go to the toilet immediately when they feel the urge;…

This study tests whether adding telerehabilitation (home-based, supervised and independent arm exercises) to usual care improves arm function and reduces disability after a stroke. Twenty adults in Brazil who had a stroke about 4 months ago will participate. The goal is to see if…

This study tests a mixed-reality system called RehAtt to help people recover movement after a stroke. Ten participants with one-sided weakness will use the system for arm, walking, and balance exercises. Researchers will interview them to see if the system is easy, motivating, an…

This study tests if pairing a gentle, non-invasive brain stimulation (tDCS) with personalized physical therapy can help people with cerebellar damage (from stroke, tumor, or degeneration) improve movement and daily function. About 30 adults aged 18-75 will participate. The goal i…

This study tests whether adding a wearable vibratory device to standard physiotherapy helps improve arm function in people with hemiplegia (paralysis on one side) after a stroke. Thirty adults who had a stroke 3 to 6 months ago will be split into two groups: one gets usual therap…

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This study tests whether combining brain stimulation (rTMS) with a brain-computer interface can help people who had a stroke more than 6 months ago regain arm movement. The brain-computer interface translates thoughts of moving into electrical muscle stimulation. The trial will e…

This study tests whether adding a gentle electrical current to the brain (tDCS) during intensive arm therapy helps women recover arm movement after a stroke. Twenty-four women will receive either real or fake stimulation over two weeks. The goal is to see if the combo improves ar…

This study tests a home grip assistance glove (SaeboGlove) to help stroke survivors use their weaker arm in everyday tasks. About 100 adults who had a stroke more than three months ago and have trouble opening their hand will try the glove at home. Researchers will compare how we…

This study tests a special hand device that helps people who had a stroke and cannot open their hand to grab things. The device is designed to let users control it themselves to pick up, move, and release objects like a glass or spoon. Researchers will compare how well 30 partici…

This study compares two physical therapy approaches—rhythmic guided movements and static muscle contractions—to see which better improves arm function, strength, and coordination in people who had a stroke 1 to 6 months ago. Forty participants aged 40 to 60 with arm weakness on o…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve word-finding in people who have trouble speaking after a stroke. Researchers will use MRI scans to guide the stimulation and see how the brain responds. The trial involves 45 participants …

This study is testing whether a device that sends small electrical pulses to leg muscles can help people with chronic stroke improve their balance and walking. Twenty participants will be exposed to slip- and trip-like disturbances on a treadmill, with and without the stimulation…

This study tests whether a gentle electrical current applied to the brain can make speech therapy more effective for people with chronic aphasia (trouble speaking or understanding language) after a stroke. About 50 adults who had a stroke at least six months ago will receive eith…

This study compares Swiss ball exercises versus kinesthetic training to see which better improves balance and mobility in people who had a stroke at least six months ago. Thirty-six participants aged 45-65 will do supervised exercises for 8 weeks. Balance and movement will be mea…

This study is testing whether combining two types of electrical stimulation can help people who have had a stroke lift their toes while walking. Participants will receive mild electrical currents on their scalp and leg while doing walking exercises. The goal is to see if this com…

This pilot study tests whether a hands-on therapy called Mobilization and Tactile Stimulation (MTS) can help stroke survivors who have unilateral neglect—a condition where they are unaware of one side of their body. Six adults who are at least 20 weeks post-stroke will receive MT…

This study tests whether combining mirror therapy with a soft robotic glove can improve hand function in people who have had a stroke and have weakness on one side. 104 participants will be randomly assigned to receive either standard rehab, mirror therapy alone, the robotic glov…

This study tests a 12-week dance program designed for stroke survivors who have weakness on one side of the body. The program combines movement improvisation and adaptive dance to help improve balance, mobility, confidence, and participation in daily and social activities. Resear…

This study tests a training program for stroke survivors who have trouble paying attention to one side of their world, a condition called spatial neglect. The training teaches mental strategies to improve awareness and daily functioning. Researchers will enroll 45 people living i…

This pilot study tests whether a 4-week home-based cognitive strategy training program can help adults with chronic stroke become more independent in daily activities like dressing and cooking. Eighteen participants will work with an occupational therapist in their own homes. The…

This study tests whether stimulating the tongue with a non-invasive device can improve arm movement and brain plasticity in people who had a stroke at least six months ago. Participants will do a 4-week strength training program for their affected arm, combined with either real o…

This study tests a special mouth exercise program for people who still have trouble swallowing 12 weeks after a stroke. Researchers want to see if the device can improve swallowing function and quality of life. The trial involves 60 participants and uses a camera test to measure …

This study tests two treatments for muscle stiffness in the lower leg after a stroke: Botox injections (a single session) and dry needling (12 weekly sessions). Researchers will measure changes in muscle reflexes and thickness in 90 participants across Belgium, Spain, and Canada.…

This study tests whether high-intensity interval training (short bursts of fast walking) is better than moderate-intensity walking for improving walking ability in people who had a stroke at least 6 months ago. 156 participants will be randomly assigned to one of two 12-week exer…

This study tests whether a brain-training technique called neurofeedback can improve vision in people who have lost part of their visual field due to a stroke. Participants will learn to increase communication between brain regions using EEG feedback. The goal is to expand the vi…

This study tests a web-based program called CARE-CITE that teaches family caregivers how to better support stroke survivors with arm exercises at home. The program includes virtual home visits and phone check-ins over four weeks. Researchers will measure improvements in arm funct…

This study tests a group-based self-management program delivered via telehealth for people who had a mild or moderate stroke within the last 6 months. The program teaches problem-solving and goal-setting skills to improve daily activities and community participation. Researchers …

This study tests a new speech therapy technique for people with aphasia (trouble speaking) after a stroke. Instead of copying a therapist's voice, participants will practice speaking along with an AI-cloned version of their own voice. The goal is to see if this personalized appro…

This study looks at whether adding music training and group leisure activities to standard hospital rehab helps people recover better after a stroke. About 90 adults who recently had a stroke will be split into three groups: usual rehab, usual rehab plus individual music training…

This study tests whether numbing a nerve in the arm or leg can reduce the severe, hard-to-treat pain some people feel after a stroke. Researchers will give 36 adults either one of two numbing medicines or a saltwater injection, then measure pain changes. The goal is to see if blo…

This study tests whether adding a vibrating device (Vibramoov®) to robotic walking training helps stroke survivors walk better than robotic training alone. Forty adults who had a stroke at least 3 months ago will take part in a 4-week rehab program. Researchers will measure walki…

This study is testing a device called MyHand 2 that helps people who have had a stroke use their affected hand better. The device is worn on the hand and assists with movement. Researchers want to see if it is easy to use and helpful for daily tasks. The study involves 60 adults …

This study tests whether adding a personalized music-based aerobic exercise program to standard physical therapy helps people recovering from a stroke. About 92 patients in the subacute phase will either receive standard therapy alone or standard therapy plus 30-minute music-guid…

This study is testing whether backward walking training can help stroke survivors improve their gait and balance. About 48 veterans who had a stroke 2-4 months ago will receive either 18 or 27 sessions of backward walking on a treadmill and over ground. Researchers will also use …

This study tests whether using conversational hypnosis during a transoesophageal echocardiogram (a heart ultrasound done through the throat) can make the procedure more comfortable for patients. Researchers will enroll 150 adults and measure their comfort levels right after the e…

This study looks at whether walking on a treadmill can improve how stroke survivors move. Many people who have had a stroke walk unevenly and have different skin temperatures on their affected side. The researchers will measure changes in walking speed, endurance, and body heat p…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve breathing muscle strength in people who had a stroke 1-3 years ago. Researchers will measure lung function in 50 participants before and after treatment. If successful, TAVNS coul…

This study compares different types and intensities of walking therapy for people who had a stroke 1-6 months ago. 100 participants will receive up to 30 one-hour sessions of either high- or low-intensity walking or general physical therapy. The goal is to see which approach best…

This study tests whether a device that provides gentle stimulation to the muscles and joints (Functional Proprioceptive Stimulation) can help people who recently had a stroke recover their balance and ability to move. The study will include 32 adults who had a stroke within the p…

This study tests whether a mild electrical current applied to the back of the brain (cerebellar tDCS) can boost language therapy for people who have trouble finding words after a stroke. Sixty adults who had a left-hemisphere stroke at least six months ago and still have aphasia …

This study tests whether adding functional electrical stimulation (FES) to arm cycling exercises improves aerobic fitness and arm function in people who had a stroke within the last 6 months. 24 participants will be split into two groups: one doing arm cycling alone, the other do…

This study tests whether adding one hour of arm-hand exercises daily (5 days a week for 4 weeks) to usual care helps stroke patients regain arm function. 80 people who had a stroke within the last 5 months will be randomly assigned to either the extra arm-hand program or a lower-…

This study tests whether a 12-week high-intensity exercise program can improve language, thinking, and physical health in 120 adults with aphasia (trouble speaking or understanding language) after a stroke. Participants are randomly assigned to either high-intensity or low-intens…

This study tests whether a device that creates a visual illusion of movement can help people who had a stroke regain use of their arm and hand. About 66 participants will either get standard therapy or standard therapy plus sessions with the device. The goal is to see if the devi…

This study tests a new program where stroke survivors coach other stroke survivors to improve well-being and quality of life. Researchers will check if the program is practical and liked by both coaches and recipients. The study involves 20 adults who had a stroke within the past…

This study tests whether a 12-week home telerehabilitation program using the MindMotion GO device can help stroke survivors improve motor function. 51 participants who had a stroke more than 30 days ago will use the device for 300 minutes of weekly therapy, guided remotely by a t…

This study tests whether a smartphone or computer app that uses artificial intelligence can improve thinking and memory in people who have had a stroke. The study will include 40 adults aged 45 to 60 who have had a stroke at least 3 months ago and still have some memory or thinki…

This study tests whether combining Transcranial Magnetic Stimulation (TMS) with speech therapy can improve language in people with mild aphasia after a stroke. About 24 adults who had a left-brain stroke at least 6 months ago will receive either real or fake TMS along with 10 day…

This study tests two rehabilitation methods—functional electrical stimulation (using mild electrical pulses) and mirror therapy (using visual feedback)—to help people who had a stroke within the last 6 months improve foot clearance and walking. 38 adults aged 18-85 will receive o…

This study tests whether using EEG neurofeedback — a way to train brain activity — can improve arm movement in people who recently had a stroke. Forty adults with a stroke within the past three weeks will either get real or fake (sham) neurofeedback, plus standard rehab. The goal…

This study tests whether a non-invasive nerve stimulation (taVNS) combined with occupational therapy can improve arm movement in people who had a stroke at least 6 months ago. 60 participants will receive the stimulation during therapy sessions. The goal is to see if this approac…

This study tests a new way to help people who had a stroke and still have trouble moving one arm. It combines a gentle, non-invasive brain stimulation (called theta-burst stimulation) with a tablet-based rehab game that guides arm reaching. About 36 chronic stroke patients will g…

This study looks at whether playing music during routine hygiene care (like bed baths) can improve comfort for stroke patients in the intensive care unit. About 102 adults who recently had a stroke will take part. After care, patients will rate their comfort using a simple pictur…

This study is testing whether listening to specially chosen music every day for 4 weeks can help reduce anxiety and depression in people who have recently had a stroke. About 132 participants will either receive the music therapy plus standard care, or standard care alone. The go…

This study tests if a less invasive freezing technique (cryoneurotomy) works as well as surgery to reduce foot stiffness in people who had a stroke. About 114 adults with chronic foot spasticity will be randomly assigned to one of the two treatments. The goal is to see if the fre…

This study tests whether gentle muscle vibration can prevent or reduce spasticity (muscle stiffness) in people who recently had a stroke. The trial has two phases: first, it validates a measurement tool, then it compares vibration therapy to a placebo in 100 patients. The goal is…

This study tests whether using a robotic exoskeleton for walking practice helps stroke survivors recover their ability to walk better than standard physical therapy. The trial will enroll 54 adults who are in the early weeks after a stroke and are staying at a rehabilitation hosp…

This study looks at two ways to help people who had a stroke more than 6 months ago get more physical activity. One group will follow a personalized exercise program at a special facility, while the other group will do their own program at home. The goal is to see which approach …

This study tests whether a virtual reality system that helps move a virtual hand using muscle signals, combined with mild brain stimulation, can improve arm function in stroke survivors. 45 people who had a mild to moderate stroke will try this approach. The goal is to see if thi…

This study tests whether sensor-based robotic arm rehabilitation can improve both thinking skills (like memory and attention) and physical movement in adults with Parkinson's disease, multiple sclerosis, or stroke. Participants will receive 25 sessions of either robotic therapy w…

This study compares two rehabilitation methods—Constraint-Induced Movement Therapy (CIMT) and Bilateral Training—both combined with electrical stimulation, to see which better improves hand function and reduces muscle tightness in people with chronic stroke. About 94 adults who h…

This study looks at whether doing high-intensity walking training more often helps people who had a stroke more than six months ago improve their walking ability. Forty adults will be assigned to either frequent or less frequent training sessions, plus a home walking program. The…

This study tests whether combining a special audio-visual training with mild brain stimulation can help people who lost part of their vision after a stroke. Forty-eight participants in the early recovery phase will either get real or fake brain stimulation during daily 90-minute …

This study tests a non-invasive method called sensory augmentation for people who have had a stroke at least 6 months ago and still have balance problems. Small vibrations are applied to the skin to enhance the body's natural sense of position, aiming to make standing steadier an…

This study tests a smartphone app that uses virtual and augmented reality to help people who had a stroke improve arm movement and thinking skills from home. Seventy chronic stroke patients will either use the app or receive standard care for six weeks. The main goal is to see if…

This study tests whether combining virtual reality training with a gentle brain stimulation technique can improve arm and hand movement in people who had a stroke at least three months ago. Researchers will enroll 100 adults to compare the effects of this combination on motor ski…

This pilot study compares a nerve-freezing technique called cryoneurolysis to standard Botox injections for treating pain and stiffness caused by spasticity in people with brain or spinal cord injuries, multiple sclerosis, or stroke. Fifty adults will be randomly assigned to rece…

This study tests a new AI system that guides stroke survivors through arm exercises at home. About 192 people who had a stroke at least 6 months ago will use a video game-like rehab tool, with or without AI help, or receive standard care. The goal is to see if the AI version impr…

This study tests a 10-week power exercise program for people who had a stroke at least 6 months ago. Researchers want to see if it improves walking, strength, and balance better than standard strength training. Sixty participants will be randomly assigned to either the power prog…

This study tests whether training on a virtual reality treadmill is practical and helpful for people who had a stroke at least 6 months ago. Thirty participants will either use the VR treadmill or do traditional exercises for 45 minutes, three times a week for 12 weeks. The goal …

This study tests a walking meditation program called iWalk for adults with neurodegenerative diseases like multiple sclerosis. The goal is to see if it's feasible and helps improve resilience, stress regulation, and thinking skills. Researchers will enroll 90 participants and mea…

This study tests whether adding gentle electrical stimulation to physical therapy can help people who have had a severe stroke and developed muscle weakness in the ICU. About 24 participants will receive either standard therapy or therapy combined with functional electrical stimu…

This pilot study tests whether a non-invasive device that stimulates the vagus nerve through the ear can help people with chronic aphasia (trouble finding words) after a stroke. Thirty-six participants will use the device at home while doing computer-based speech therapy for six …

This study tests whether adding gentle vibrations to the leg muscles can help people recovering from a stroke walk faster. About 70 patients who had a stroke within the past 3 months will either get real vibrations or a fake treatment during their regular rehab. The goal is to se…

This study tests a non-invasive brain stimulation technique called iTBS to see if it can improve balance and leg movement in people who had a stroke more than six months ago. Researchers will measure changes in walking and brain activity. The goal is to find a safe, practical way…

This study tests whether a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) can improve arm and leg movement in people who had a stroke more than six months ago. 48 participants will receive either real or sham stimulation over 15 sessio…

This study tests a therapy called m-CIMT for people who recently had a stroke and have weakness in one arm. The therapy involves restraining the good arm and doing specific exercises with the weak arm to improve its use. Researchers will measure changes in arm function, daily act…

This study investigates how stroke affects arm swing during walking and whether real-time virtual reality feedback can help improve it. Researchers will measure muscle activity and movement in both stroke survivors and healthy adults to understand the differences. Participants wi…

This study looks at how stroke changes the way people move their arms when walking. Researchers will measure brain activity and muscle patterns in 84 people (some who had a stroke and some healthy) while they walk on a treadmill. The goal is to understand why arm swing is often a…

This study follows 65 infants who had a stroke around birth, tracking their brain development and motor skills over two years. Researchers use MRI scans, brain stimulation, and movement tests to find markers of recovery. The goal is to understand how the brain heals, which could …

This study looks at whether lying flat (0 degrees) or with the head raised (30 degrees or more) after a stroke clot removal procedure helps people recover better. About 2240 adults who had a stroke from a large blood vessel blockage will be randomly assigned to one of the two hea…

This study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people scheduled for DBS surgery will have extra temporary electrodes placed on the brain to measure muscle activity during stimu…

Researchers are studying how well people who have had a stroke learn a complex arm and hand skill when they train with one arm versus both arms. Participants include healthy volunteers, people in the early days after a stroke, and people more than six months past a stroke. They p…

This study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …

Researchers want to know whether training one arm after a stroke can improve the other arm, and which brain regions make that possible. The study includes healthy adults, people in the early days after a stroke, and people with long-term stroke effects. Participants play serious …

Researchers at the University of Miami are studying whether advanced eye imaging devices can reveal useful information about the eye in health and disease. The study has two parts: one observes the eyes of healthy people and people with conditions such as multiple sclerosis, dry …

This study will look at 54,000 adults having surgery with general anesthesia to see how different oxygen levels affect their recovery. Patients will receive lower, intermediate, or higher oxygen during their operation. The goal is to find which oxygen level reduces the risk of or…

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and raises the risk of strokes and dementia, over nine years. Researchers will use brain scans, blood tests, and other exams to track how the disease changes blood vessels and thinkin…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE Suit affects their balance and risk of falling over time. Participants will be followed routinely, and researcher…

Researchers are following 10,000 registered nurses in Xiamen, China, to see how genes, lifestyle, and environment relate to common chronic diseases like high blood pressure, heart disease, stroke, diabetes, kidney disease, and some cancers. The study collects health and lifestyle…

This study is testing a new PET scan tracer called 18F-GP1 that sticks to activated platelets in blood clots. Researchers will scan 120 adults who recently had an ischemic stroke to see if they can find where clots are coming from. The goal is to better understand different types…

Researchers are building a large database of high-resolution MRI scans from stroke patients in China to study the fatty plaques inside brain arteries. The study enrolls adults who recently had an ischemic stroke and have a specific plaque in a major brain artery. By tracking thes…

This study looks at whether damage to the blood-brain barrier right after a stroke can help predict who will have memory or thinking problems later. Researchers will follow 150 stroke survivors for three years, checking their thinking skills by phone. The goal is to better unders…

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This study uses a special robot called IntelliArm to measure how arm stiffness, spasticity, and movement change during recovery from a first stroke. Researchers will track 56 people who had a stroke less than a month ago, measuring their arm function with standard tests and robot…

This study aims to understand how the brain responds to magnetic stimulation when it is timed with natural brain waves. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to find ways to make brain stimulation more effective for im…

This study examines how hospital admissions and treatments for stroke and transient ischemic attack (TIA) changed during the COVID-19 pandemic across Europe. Researchers will collect data from about 40 stroke units, covering admissions, length of stay, and procedures like thrombo…

This study aims to develop and fine-tune a medical artificial intelligence (AI) model to assist with diagnosing and managing gastric, cardiovascular, and cerebrovascular diseases. Researchers will use a large dataset of patient records, medical images, and doctor-patient dialogue…

This small study tests a smartphone app that creates a 'digital twin' of the patient to help manage health after a stroke, moyamoya disease, or cerebral amyloid angiopathy. Twenty adults will either use the app plus standard care, or standard care alone. The goal is to see if pat…

This study tests different power levels and timing of low-intensity focused ultrasound (LIFUS) to see which best improves arm movement and motor learning in stroke survivors. 24 adults who had a stroke at least 6 months ago and have arm weakness will participate. The goal is to f…

This trial tests whether one session of high-frequency repetitive transcranial magnetic stimulation (rTMS) can increase brain activity in the motor cortex of stroke patients with severe arm weakness. Participants, who have had a stroke more than six months ago and cannot voluntar…

This trial tests a brain-computer interface called CortiCom, which is surgically placed on the brain's surface to record signals related to speech and arm movement. The goal is to see if these signals can be decoded to control software and devices, potentially helping people with…

This study aims to see if brain scans and a technique called transcranial magnetic stimulation (TMS) can predict how well someone will recover arm movement after a stroke. Researchers will collect data from 657 adults who recently had a stroke and have arm weakness. The goal is t…

This study is testing whether a light-based cap (HD-DOT) can measure how well the brain responds to changes in carbon dioxide, a key indicator of stroke risk. Researchers will compare this cap to standard MRI in people with and without sickle cell disease, aged 6 to 70. Participa…

This study is a long-running registry that collects detailed health information from all stroke and dementia patients in Erlangen, Germany. It aims to understand how these diseases develop and affect people over time, regardless of age or severity. Participants are followed for l…

This study tests whether a one-on-one nursing education session just before a stroke patient goes home can improve how well they follow their medication and care plan. Researchers will enroll 300 stroke survivors who are returning home and randomly assign half to receive the extr…

This study tests how Tizanidine, a drug used for muscle stiffness, changes arm movement in people who have had a stroke. Researchers will measure brain activity, muscle responses, and movement patterns in 64 participants. The goal is to understand what limits movement after strok…

This study investigates how a recent stroke affects the ability to learn new motor skills that require using both arms or hands together. Researchers will use robotic devices to measure learning and brain imaging to see which brain areas are involved. The goal is to understand wh…

This study is collecting blood samples and health data from 15,000 symptom-free adults over 40 to understand what healthy aging looks like at the molecular level. By tracking participants over time, researchers hope to establish normal ranges for thousands of blood markers and id…

This study investigates whether physical exam findings called somatic dysfunction — impaired function of the body's framework — can be linked to energy expenditure, heart rate variability, and quality of life in people who have had a stroke. Researchers will assess 100 chronic st…

This study looks at how blood levels of common blood thinners (apixaban, dabigatran, edoxaban, and rivaroxaban) change over time in Chinese patients with atrial fibrillation. Researchers will take blood samples before and after stopping the medication for medical procedures. The …

This study tests a virtual coaching program for stroke survivors and their family members. The goal is to see if it can help lower the risk of another stroke and keep the brain healthy. About 40 people will take part in this early-stage research.

This study investigates whether ultrasound measurements of thigh muscle thickness can help detect sarcopenia (muscle loss) and fear of movement in people who have had an ischemic stroke. Researchers will compare ultrasound results with standard tests like handgrip strength and a …

This study looks at whether special MRI scans can help predict which people with severe narrowing of brain arteries (70-99% stenosis) are most likely to have another stroke. Participants have already had a minor stroke and are enrolled in a larger treatment trial. They will get a…

This study follows 100 stroke survivors over six months to understand how sitting balance, standing balance, and walking recover. Using wearable sensors and an interactive assessment game, researchers measure movement, coordination, and reaction time. The goal is to identify reco…

This study tests whether a 6-week program that combines a pedometer with phone or video coaching is practical for people who had a stroke at least 6 months ago. 24 participants will track their steps and set goals with an occupational therapist. The main goal is to see if people …

This study aims to learn how patients with severe stroke move during their hospital stay. Fifty adults will wear a small activity tracker (activPAL) that records lying, sitting, standing, and stepping. Researchers will compare this data with standard mobility goals to understand …

This study tests whether gentle muscle vibrations can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and spinal cord activity in 56 participants before, during, and after a 5-week vibration treatment. The goal is to un…

This observational study investigates why some people develop epilepsy after a stroke, while others do not. Researchers will compare first-time stroke patients with healthy volunteers using brain imaging (MRI), electrical brain recordings (EEG), and overnight sleep studies. The g…

This study investigates whether monitoring brain blood flow during heart surgery can help predict strokes afterward. Researchers will use non-invasive sensors to track how well the brain regulates its own blood supply during different phases of surgery. The goal is to develop a m…

This study aims to uncover genetic and environmental risk factors for hemorrhagic stroke, a type of stroke caused by bleeding in the brain. Researchers will analyze DNA, RNA, and blood samples from 1,000 adults who have had such a stroke, comparing them to healthy controls. By id…

This study is translating and testing a French version of the Trunk Impairment Scale (TIS), a tool that measures trunk control and balance while sitting. Researchers will enroll 67 stroke patients to check if the scale is accurate and reliable. The goal is to give French-speaking…

This study is testing whether low-intensity focused ultrasound can help people with severe brain injuries who have not fully recovered consciousness. Researchers will measure changes in behavior and brain activity after ultrasound sessions. The study involves 36 participants and …

This study uses PET and MRI brain scans to compare the activity of two key brain chemicals—dopamine and acetylcholine—in 30 people who have had a stroke, half with apathy and half without. The goal is to better understand what causes apathy after a stroke, which could eventually …

This observational study is looking at 250 people who have had a stroke or mini-stroke due to narrowing of arteries in the brain. Researchers want to see if a specific platelet protein (FcγRIIa) and blood flow patterns on MRI can help predict who will have another stroke within a…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study looks at whether being left-handed or right-handed affects how well people recover arm movement after a stroke. Researchers will follow 500 adults who had a recent stroke for 6 months, measuring arm function with standard tests. The goal is to see if left-handed people…

This study aims to validate new guidelines for placing surface EMG electrodes on the calf muscles of people who have had a stroke. Researchers will compare the new EPICA guidelines with standard SENIAM guidelines using ultrasound to see which placement gives more accurate muscle …

This study uses a robotic arm and brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke and those who haven't. Researchers will measure movement paths, speeds, and accuracy. The goal is to understand brain changes after st…

This study follows 180 adults with cerebral small vessel disease to see how their condition changes over time after a stroke. Researchers will use MRI scans and blood tests to track disease progression and look for links to thinking skills, daily function, and stroke recurrence. …

This study tests whether adding immersive virtual reality (VR) to standard physical therapy helps people who recently had a stroke regain arm movement and improve quality of life. Researchers will also look at blood markers and genes that might predict recovery. About 120 adults …

This study is looking at whether a blood test measuring DNA methylation can predict the risk of silent brain injury in elderly patients undergoing TAVR, a minimally invasive heart valve replacement. About 542 people over age 70 with severe aortic stenosis will have their DNA test…

This study is testing three different doses of a non-invasive brain stimulation technique called rTMS in 26 chronic stroke survivors with arm weakness. The goal is to see which dose best boosts brain signals to the hand muscles and improves motor learning. Participants will recei…

This study tests a digital lifestyle platform designed to support patients after they leave inpatient rehabilitation. It includes people with COPD, heart problems, fractures, or minor stroke. Participants use the platform for six months, receiving personalized recommendations and…

This study tests a new set of procedures called the HI-SPEED Protocol, designed to help hospitals evaluate stroke patients faster and decide who needs to be transferred for advanced care. The goal is to reduce the time patients spend in the first hospital before being moved to a …

This 10-year study will follow 500 Korean adults with CADASIL, a genetic brain disease that causes strokes and dementia. Researchers will track symptoms, brain scans, memory tests, and genetic information to understand how the disease progresses in Koreans. The goal is to improve…

This study looks at how artificial intelligence (AI) can help emergency call operators quickly identify life-threatening situations like cardiac arrest, stroke, or severe breathing problems. Researchers will analyze millions of past emergency calls to train AI models to recognize…

This study looks at whether new, quick tests that measure how fast people can move can help doctors diagnose brain diseases like Alzheimer's and predict recovery after a stroke. Researchers will test 129 adults aged 40-85 with stroke or memory problems. The goal is to see if thes…

This study looks at sleep problems like sleep apnea and insomnia in 226 people who have had a stroke. Researchers want to see how these sleep issues affect recovery, daily activities, and quality of life. Participants will use a home sleep test and a smartwatch to track sleep and…

This study explores whether a special MRI technique can help people who have had a stroke improve their reading. Participants will practice controlling their own brain activity using real-time feedback from the MRI scanner. The goal is to retrain the brain's language areas to wor…

This study follows 24 people who had a stroke and were recently diagnosed with atrial fibrillation (AF), a heart rhythm problem. Researchers want to see how AF changes over two years by monitoring heart activity, blood markers, and heart structure. The goal is to better understan…

This study compares how well stroke neurologists and a deep learning AI model predict recovery in 250 stroke patients. Researchers will track actual disability at 24 hours and 3 months, then compare those results to predictions made by doctors and the AI. The goal is to understan…

This study tests whether a new type of exercise that retrains how muscles work together can improve arm function in people who have had a stroke. Researchers will compare this approach to standard strength training in 74 participants. The goal is to see if changing muscle coordin…

This study follows 600 adults who have had their first stroke to see how their thinking and memory change over time. Researchers will look at factors like brain reserve and daily habits to understand why some people get worse while others stay stable. The goal is to better predic…

This study tests whether a computer model can predict which reading treatment works best for people who developed dyslexia after a stroke. Twelve participants will each try two different therapies—phonomotor treatment and semantic feature analysis—for 60 hours each. The goal is t…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will participat…

This study is testing a special glove equipped with sensors to measure how well stroke survivors can feel touch. The glove is part of a larger robotic rehabilitation program aimed at improving both movement and thinking skills. Researchers will enroll 126 people who had a stroke …

This study looks at how swelling around a brain bleed affects recovery in 500 stroke patients. Researchers will use MRI scans and blood tests to understand the swelling's role. The goal is to find new ways to treat this devastating type of stroke.

This study will track how often and how intensely patients with moderate to severe brain injury are moved or exercised while in intensive care units in Scandinavia. Researchers want to see if more movement is linked to better outcomes and safety. About 198 adults on breathing mac…

This study looks at whether a fast genetic test can help doctors pick the best blood-thinning medication for people who have had a minor stroke or a high-risk mini-stroke (TIA). The test checks a gene called CYP2C19, which affects how the body processes certain antiplatelet drugs…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study is creating a biological bank of blood samples from 1,000 people with atrial fibrillation (AF) and stroke. Researchers will collect DNA and plasma to study the genetic roots of these conditions. The goal is to better understand why AF leads to stroke and find new drug …

This study looks at why about half of stroke patients don't recover well even after doctors successfully remove a blood clot from their brain. Researchers will use special MRI scans to measure blood flow changes in the brain at 3 days, 7 days, and 90 days after the procedure. The…

This study tests whether a gentle electrical current applied to the brain (tACS) can improve hand movement in people who had a stroke more than 6 months ago. Researchers will use brain scans and EEG to see how the stimulation changes brain activity. 45 participants (including hea…

This study is analyzing blood samples from 500 people who recently had a stroke and comparing them to healthy volunteers. Researchers are looking for specific RNA molecules that could serve as biomarkers to detect stroke and predict how well patients will recover. The goal is to …

This study follows 100 stroke survivors with arm weakness to see how their own sense of arm use changes during intensive rehab. Researchers compare patients' perceptions with actual arm function using standard tests. The goal is to better understand the gap between what patients …

This study collects data from 336 adults aged 18-85 who had an acute ischemic stroke and received a new clot-busting drug called non-immune staphylokinase. Researchers will check how often bleeding in the brain occurs and compare results to the standard drug alteplase. The goal i…

This study examines blood samples from 300 adults who had a stroke and received a procedure to remove the clot. Researchers look for specific RNA molecules that change before and after treatment. The goal is to find markers that can help predict how well patients will recover and…

This study looks at whether people who have a blood clot in the lungs (pulmonary embolism) are more likely to have a stroke if they also have a small hole in their heart (called a PFO). About 1 in 4 people have this hole, which can let a clot travel to the brain. Researchers will…

This study tests whether speech therapy delivered via video call works as well as traditional in-clinic therapy for people with aphasia, a language disorder caused by stroke. One hundred adults who had a stroke at least a year ago will receive either remote or in-person therapy. …

This study looks for brain signals that can track how well stroke patients recover their ability to walk. Researchers will use a mobile brain scanner while patients walk with a robotic device. The goal is to find markers that could help doctors personalize therapy and predict rec…

This early study tests whether a non-invasive device that gently stimulates a nerve in the ear (taVNS) can change brain activity and genetic markers in people who recently had a stroke. Forty-four participants with arm weakness will receive either real or sham stimulation. Resear…

This study tests whether a gentle electrical current applied to the spine (called tsDCS) can improve reflexes, walking, and balance in people who have leg weakness after a stroke. Researchers will measure changes in movement and adaptation over 15 sessions. The goal is to underst…

This study is looking for biological clues to explain why some stroke survivors improve their walking with high-intensity interval training (HIIT) while others do not. Researchers will measure blood lactate, brain chemicals, and blood flow in 55 veterans with chronic stroke. The …

This study follows 400 stroke patients in rehabilitation units to understand how walking and balance improve during the first six months after a stroke. Researchers will measure walking ability and balance using simple tests. The goal is to better predict recovery and guide thera…

This study examines the role of the plantaris, a small calf muscle, in children having surgery for tight ankles (equinus). Researchers will randomly change the order of tendon cuts during surgery to measure how much each contributes to ankle movement. The goal is to understand if…

This study looks at how the brain recovers arm movement after a stroke. Researchers will study 50 people who had a stroke 3 to 6 months ago and have trouble moving their arm. Some will get 30 hours of special arm therapy over 6 weeks, while others get usual care. The goal is to l…

This study explores how targeted brain stimulation can improve movement speed in people who have had a stroke. Researchers will first test the technique in 60 healthy volunteers, then in 20 stroke patients. The goal is to understand which brain areas control action speed and whet…

This study compares a new, data-driven method for emergency responders to decide which hospital to take a stroke patient to, versus the current standard method. The goal is to see if the new approach helps rural patients get to a hospital that can perform specialized clot-removal…

This study looks at whether paying attention to an outside target (external focus) or to your own body movements (internal focus) helps people who had a stroke stand up from a chair more evenly. Twenty adults who had a stroke at least six months ago will try both approaches. The …

This study follows 150 people who recently had a stroke to see how their walking ability recovers over time. Researchers will measure walking speed and distance, and test if specific therapies can improve recovery. The goal is to create better rules for predicting and enhancing r…

This study tests whether a 3D image overlay (fusion imaging) helps doctors reach and remove blood clots in the brain faster during a standard stroke procedure. About 300 adults having emergency clot removal will be randomly assigned to get the extra imaging or not. The goal is to…

This study collects blood, clots, and tissue from up to 1000 people having procedures for stroke or other blood vessel problems in the brain. Researchers will analyze these samples to find biological markers and understand inflammation. The goal is to learn more about how stroke …

This study aims to better understand the fatigue many people feel months or years after a stroke. About 30 adults in French-speaking Switzerland who have had a stroke will fill out a one-time, anonymous questionnaire about their fatigue, daily life, and coping strategies. There a…

This study is testing whether wearable sensors can accurately measure how people climb stairs. Researchers will compare sensor data to traditional stopwatch timing in healthy volunteers and people with conditions like cerebral palsy, Parkinson's disease, and stroke. The goal is t…

This study is following 500 adults who had an ischemic stroke (a clot blocking blood flow in the brain). Researchers are collecting blood samples, brain scans, and health data to find new markers that can predict how well someone will recover and whether they will develop heart p…

This study aims to find early signs that predict quality of life more than four years after a minor ischemic stroke. Researchers will analyze data from 1,000 patients, including MRI scans, saliva samples, and questionnaires. The goal is to build a model that helps doctors underst…

This long-term study is tracking 5,000 adults in Hong Kong who either have a brain disease (like stroke or dementia) or are at high risk due to family history or early signs. Researchers will collect medical records and questionnaires every 6 months to find what factors lead to b…

This study is looking back at medical records of 2,600 stroke patients who received clot-busting drugs between 4.5 and 24 hours after their stroke started. The goal is to see if giving the drug later than the usual 4.5-hour window can still lead to good recovery. The study does n…

This study is looking at whether simple body measurements, like muscle size and body composition, can help predict how well someone will recover after a stroke. Researchers will measure the thickness and size of a specific muscle in the head and use a special scale to check body …

This study looks at people with cerebral small vessel disease, a common condition in older adults that can lead to stroke and dementia. Researchers will measure brain activity using EEG and test whether home-based cognitive training or mild brain stimulation can improve thinking …

This study is creating a large registry and tissue bank for people with mitochondrial disorders. Researchers will collect medical information and samples from up to 1,000 participants, including those diagnosed with or suspected to have a mitochondrial disease. The goal is to gat…

This study is testing a new type of MRI scanner, called Field-Cycling Imaging (FCI), to see if it can detect brain changes within the first day of a stroke. Researchers will compare FCI scans with standard MRI scans in 40 acute stroke patients. Participants will also provide bloo…

This study looks at blood clots removed from stroke patients during a procedure called thrombectomy. Researchers will also take a small blood sample. They want to see if the clot's makeup and blood markers can tell us more about what caused the stroke, how well treatment worked, …

This study is following 500 people with cerebral small vessel disease (CSVD) to see how their genes affect their brain scans, symptoms, and health over time. Participants get genetic testing and MRI scans at the start and again after 1-2 years. The goal is to better understand th…

This study is collecting data from 5,000 people who had a stroke caused by a blood clot and received endovascular treatment (a procedure to remove the clot). The goal is to measure how well patients recover neurologically three months later. This information is rarely collected b…

This study is testing whether a special heart MRI can measure scarring in the left atrium, which might lead to atrial fibrillation. Researchers will enroll 100 people who had a stroke with no clear cause and who are already scheduled to get an implantable heart monitor. The goal …

This study is testing whether sending a portable ECG monitor to people with elevated NT-proBNP (a heart stress marker) can catch hidden atrial fibrillation and reduce strokes. 4,000 adults aged 40+ without known AF will be randomly assigned to either 7 days of home monitoring or …

This study is looking at whether certain gene changes (variants) in a protein called annexin A2 are linked to strokes that happen for no clear reason, especially in younger adults. Researchers will compare blood samples from 240 people who have had a stroke with no known cause. T…

This study looks at 92 people who had a stroke with no clear cause and received a small heart monitor. Researchers will use an artificial intelligence program called SmartECG-AF to analyze their ECGs and predict who might develop atrial fibrillation (an irregular heartbeat) in th…

This study follows 250 atrial fibrillation patients who received a left atrial appendage closure device to prevent strokes. The procedure blocks a small pouch in the heart where clots often form, allowing patients to avoid long-term blood thinners. Researchers will track how many…

This study uses powerful 3T and 7T MRI scanners to create detailed maps of brain activity and connections in 100 stroke patients and 10 healthy volunteers. The goal is to understand how the brain reorganizes after a stroke and to identify patterns linked to motor deficits. Findin…

This study tests whether combining non-invasive brain and spinal cord stimulation during a movement task can improve hand function and thinking in people with stroke or spinal cord injury. 45 participants will receive both types of stimulation separately and together to see if th…

This study is a large registry that will collect health information from up to 60,000 people with both heart and kidney disease. The goal is to better understand how these conditions interact and to find ways to predict and improve patient outcomes. No new treatments or procedure…

This study looks at whether a heart ultrasound technique called left atrial strain can predict stroke risk in people who had a stroke with no known cause. Researchers will measure heart function in 900 adults and track who has another stroke. The goal is to find a safe, low-cost …

This study will track 10,000 adults who receive tenecteplase for a stroke caused by a blood clot. Researchers want to see how well patients recover and if there are any safety issues when the drug is used in everyday hospital care. The goal is to improve stroke treatment across C…

This study is a registry that gathers medical information from up to 40,000 people who have had surgery for stroke, brain aneurysm, or other brain blood vessel problems. Researchers will look at this data to find patterns that help predict recovery and compare different treatment…

This study is testing a new questionnaire called the Pressure Relief Frequency Scale (PReFS) to see if it can reliably help wheelchair users with neurologic disorders (like spinal cord injury, stroke, or traumatic brain injury) decide how often they need to relieve pressure to pr…

This observational study is testing whether advanced heart imaging (MRI or CT scans) can find blood clots in the heart that standard ultrasound might miss. It involves 125 people who had a stroke of unknown cause and have mild heart disease. The goal is to better understand strok…

This study is working to create better methods for evaluating how children with and without stroke or cerebral palsy use their arms and hands. Researchers will observe 80 children, including those with perinatal stroke and typically developing infants, using video and play-based …

This study follows 213 adults recovering from a first ischemic stroke to see if the intensity of inpatient rehabilitation (high vs. moderate) affects their functional recovery at six months. It also compares people whose stroke was linked to atrial fibrillation with those whose s…

This study explores whether a new system using ultrasound and light sensors can remotely monitor brain blood flow in people who have had a stroke. Researchers will test the technology in 140 participants, including healthy older adults and those with stroke, dementia, depression,…

This study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…

This study tests whether a special blood pressure cuff (Doctormate) can be used during helicopter transport to protect brain tissue in people having a severe stroke. Ten patients with large vessel occlusion will receive remote limb ischemic conditioning (RLIC) while being flown t…