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Massive brain injury registry aims to predict patient outcomes

NCT ID NCT04994756

Knowledge-focused Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is a registry that gathers medical information from up to 40,000 people who have had surgery for stroke, brain aneurysm, or other brain blood vessel problems. Researchers will look at this data to find patterns that help predict recovery and compare different treatment methods. No new treatments are being tested; the goal is to learn from real-world results to improve future care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2019

Expected to finish

Jan 2055

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Any patients between 1 and 120 years of age, undergoing surgical intervention for central nervous system vascular lesions.

Ages

1 year to 120 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Undergoing surgical intervention for central nervous system vascular lesion * Between 1 and 120 years of age Exclusion Criteria: * No exclusion criteria

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

brain aneurysm intracranial thrombosis stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aneurysm, brain Stroke Thromboses, intracranial

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    63 sites in 9 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Albany Medical Center

    RECRUITING

    Albany, New York, 12208, United States

  • Alleghany Hospital

    RECRUITING

    Pittsburgh, Pennsylvania, 15212, United States

  • Baylor College of Medicine

    RECRUITING

    Houston, Texas, 77030, United States

  • Beth Israel Deaconess Medical Center

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Centro Hospitalar Universitário de Lisboa Central

    RECRUITING

    Lisbon, Portugal

  • Chonnam National University Hospital

    RECRUITING

    Gwangju, South Korea

  • Cottage Health Research Institute

    RECRUITING

    Santa Barbara, California, 93105, United States

  • Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Endeavor Health

    RECRUITING

    Evanston, Illinois, 60201, United States

  • Geisinger Medical Group

    RECRUITING

    Wilkes-Barre, Pennsylvania, 18702, United States

  • Global Neurosciences Institute

    RECRUITING

    Pennington, New Jersey, 08534, United States

  • HCA Houston Healthcare Kingwood

    RECRUITING

    Kingwood, Texas, 77339, United States

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, Spain

  • Hyogo College of Medicine

    RECRUITING

    Hyōgo, Japan

  • Indiana University

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Loma Linda University

    RECRUITING

    Loma Linda, California, 92350, United States

  • Louisiana State University Health Shreveport

    RECRUITING

    Shreveport, Louisiana, 71103, United States

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Mayo Clinic in Florida

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Medical University of South Carolina

    RECRUITING

    Charleston, South Carolina, 29425, United States

  • Mercy Health

    RECRUITING

    Toledo, Ohio, 43608, United States

  • Montefiore Medical Center

    RECRUITING

    The Bronx, New York, 10467, United States

  • Médica Uruguaya

    RECRUITING

    Montevideo, Uruguay

  • Nuvance Health

    RECRUITING

    Danbury, Connecticut, 06810, United States

  • Piedmont Healthcare

    RECRUITING

    Atlanta, Georgia, 30318, United States

  • Portsmouth Regional Hospital

    RECRUITING

    Portsmouth, New Hampshire, 03801, United States

  • Rush University

    RECRUITING

    Chicago, Illinois, 60612, United States

  • Rutgers University

    RECRUITING

    New Brunswick, New Jersey, 08901, United States

  • Stony Brook University

    RECRUITING

    Stony Brook, New York, 11794, United States

  • Texas Stroke Institute

    RECRUITING

    Plano, Texas, 75075, United States

  • The Feinstein Institutes for Medical Research

    RECRUITING

    Great Neck, New York, 11021, United States

  • The Queens Health Center

    RECRUITING

    Honolulu, Hawaii, 96813, United States

  • The University of Texas Medical Branch at Galveston

    RECRUITING

    Galveston, Texas, 77555, United States

  • Thomas Jefferson University

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • Tulane University

    RECRUITING

    New Orleans, Louisiana, 70112, United States

  • University Clinic for Neuroradiology

    RECRUITING

    Magdeburg, Germany

  • University of Alabama at Birmingham

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • University of Chicago

    RECRUITING

    Chicago, Illinois, 60637, United States

  • University of Florida

    RECRUITING

    Gainesville, Florida, 32611, United States

  • University of Illinois

    RECRUITING

    Chicago, Illinois, 60637, United States

  • University of Iowa

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • University of Kansas Medical Center

    RECRUITING

    Kansas City, Kansas, 66103, United States

  • University of Louisville

    RECRUITING

    Louisville, Kentucky, 40292, United States

  • University of Miami Health System

    RECRUITING

    Miami, Florida, 33136, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of Michigan Health-West

    RECRUITING

    Wyoming, Michigan, 49519, United States

  • University of North Carolina

    RECRUITING

    Raleigh, North Carolina, 27607, United States

  • University of Oklahoma

    RECRUITING

    Oklahoma City, Oklahoma, 73019, United States

  • University of Saskatchewan

    RECRUITING

    Saskatoon, Canada

  • University of South Florida

    RECRUITING

    Tampa, Florida, 33620, United States

  • University of Tennessee Health Science Center

    RECRUITING

    Memphis, Tennessee, 38163, United States

  • University of Texas Health Science Center at San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

  • University of Utah

    RECRUITING

    Salt Lake City, Utah, 84112, United States

  • University of Virginia

    RECRUITING

    Charlottesville, Virginia, 22904, United States

  • University of Washington

    RECRUITING

    Seattle, Washington, 98195, United States

  • Universitätsmedizin Göttingen

    RECRUITING

    Göttingen, Germany

  • Universitätsspital Basel

    RECRUITING

    Basel, Switzerland

  • Valley Baptist Medical Center

    RECRUITING

    Harlingen, Texas, 78550, United States

  • Wake Forest Baptist Health

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

  • Washington University in St. Louis

    RECRUITING

    St Louis, Missouri, 63110, United States

  • WellSpan York Hospital

    RECRUITING

    York, Pennsylvania, 17403, United States

  • West Virginia University

    RECRUITING

    Morgantown, West Virginia, 26506, United States

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06520, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.