Can a baby aspirin prevent strokes as well as a full dose?
NCT ID NCT05868525
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a low dose (81 mg) of daily aspirin works as well as a higher dose (325 mg) to prevent strokes in people who have injured blood vessels in their neck or head. About 98 adults with blunt cerebrovascular injury will be randomly assigned to one of the two doses. The goal is to see if the lower dose can prevent strokes with fewer bleeding complications.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Aspirin (acetylsalicylic acid)
- What this could lead to
- If it works, this could show that a lower dose of aspirin is just as effective at preventing strokes after a neck or head vessel injury, with fewer side effects.
- What could go wrong
- This is a small pilot study (98 people), so results may not be definitive. Aspirin can cause bleeding, and the higher dose may increase that risk without preventing more strokes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 98 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2023
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 * All patients with blunt cerebrovascular injury are diagnosed by computed tomography angiography (CTA) upon admission Exclusion Criteria: * Age \<18 * Pregnant women * No enteral route access for Aspirin administration * Patients who are on Heparin drip or other full dose anticoagulation when BCVI diagnosed * Patients who are on other Anti-Platelets aside from Aspirin when BCVI diagnosed * Patients with BCVI grade 5 injury based on Biffl classification * Presence of any contraindication or history of allergy to Aspirin * Patient with the diagnosis of acute stroke at the time of BCVI diagnosis matching the injured vessel territory on imaging * Patients with acute spinal trauma that needs surgical intervention
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Loma Linda University Medical Center
RECRUITINGLoma Linda, California, 92354, United States