Vibrating muscles may ease Post-Stroke spasticity, early trial hopes
NCT ID NCT05315726
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether gentle muscle vibration can prevent or reduce spasticity (muscle stiffness) in people who recently had a stroke. The trial has two phases: first, it validates a measurement tool, then it compares vibration therapy to a placebo in 100 patients. The goal is to see if vibration improves arm function and brain plasticity during the critical early recovery window.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- muscle vibration
- What this could lead to
- If it works, this could provide a simple, non-drug therapy to reduce muscle stiffness and improve arm function soon after a stroke.
- What could go wrong
- This is an early-stage study with no prior results in the acute phase. The vibration may not reduce spasticity more than placebo, and benefits may be small or short-lived.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 165 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2022
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Phase 1: * Adult patient, * Medically stable on medical assessment, with no contraindications to stroke rehabilitation management management (no medical problems or acute intercurrent medical events), * Have had an ischemic and/or hemorrhagic stroke (\> 3 months post-stroke), impacting the motor skills of the upper limbs, * 1 ≤ MAS \< 4 on elbow or wrist flexors, * Having given oral consent. Phase 2: * Adult patient \> 18 years old, * Able to follow a rehabilitation program on medical opinion (no medical issues or acute intercurrent medical events), * First stroke ever \< 6 weeks, confirmed by imaging, * Hemiparesis or hemiplegia of the upper limb (FMA-UE score \< 48), particularly in the wrist and elbow flexors, * Requiring inpatient or outpatient hospitalization in a rehabilitation center, * Having given oral consent. Exclusion Criteria: * Phases 1 and 2: * Significant pain on mobilization of the wrist or elbow (VAS \> 5/10), * Presence of other neurological, muscular or osteoarticular conditions altering upper limb function, * Apparent wound, which may postpone inclusion, or very fragile skin, * Significant cognitive impairments: inability to understand simple instructions or give consent of any kind (not included if: LAST scores \< 5/7 in comprehension, and if YES/NO answers are unreliable), * Not covered by national health insurance, * Being pregnant or breastfeeding, * Being under guardianship or curatorship. * Person subject to a measure of legal protection
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Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Chu Dijon Bourgogne
RECRUITINGDijon, 21000, France
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SSR Marguerite BOUCICAUT
RECRUITINGChalon-sur-Saône, 71100, France