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Eye ultrasound could speed up brain swelling detection

NCT ID NCT07332234

Diagnosis Sponsor: Spitalul Clinic de Boli Infecțioase și tropicale "Dr. Victor Babeș" Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a simple ultrasound of the optic nerve can quickly detect brain swelling and inflammation in ICU patients with conditions like meningitis, encephalitis, or stroke. Researchers will measure the optic nerve sheath diameter in 200 adults and compare it with standard tests. If accurate, this painless, low-cost method could help doctors make faster treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Optic nerve sheath diameter measurement via ultrasound
What this could lead to
If successful, this could provide a quick, safe, and low-cost bedside tool to detect brain swelling and inflammation, helping doctors make faster treatment decisions.
What could go wrong
This is an early diagnostic study, not a treatment trial. The ultrasound method may not be accurate enough to replace current standard tests, and results may vary by patient condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients admitted into the Anesthesia and Intensive Care Department of the Fundeni Clinical Institute in Bucharest, and the Anesthesia and Intensive Care Department and Infectious Diseases departments of the "Dr. Victor Babes" Hospital of Infectious Diseases in Bucharest

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients admitted into one of the specified wards of the involved hospitals * Patients aged 18-60 years * Suspected meningitis, encephalitis, stroke or cerebral tumors Exclusion Criteria: * Age under 18 years or over 60 years old * Ocular lesions preventing ocular ultrasound (palpebral infections, cornean erosions, glaucoma, trauma) * Conditions preventing lumbar puncture (coagulation disorders, epidural abscesses, local infections)

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Conditions

The condition(s) this trial relates to.

brain neoplasm encephalitis intracranial hypertension meningitis meningoencephalitis neoplasm of cerebral hemisphere stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral tumors Intracranial hypertension Meningitis Meningitis/encephalitis Stroke Ultrasound

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • "Dr. Victor Babeș" Clinical Hospital for Infectious and Tropical Diseases

    RECRUITING

    Bucharest, Bucharest, 030303, Romania

  • Fundeni Clinical Institute

    RECRUITING

    Bucharest, Bucharest, 022315, Romania

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