Digestive system disorder

This study tested whether offering hepatitis C (HCV) treatment right at methadone clinics helps more people get cured compared to sending them to outside specialists. Over 600 adults on opioid addiction therapy took part across 13 clinics in Ukraine. Some clinics provided simplif…

This trial tests whether an 8-week course of the combination pill elbasvir/grazoprevir can cure chronic hepatitis C in people with genotype 1b who have not been treated before and have mild liver fibrosis. The main goal is to see if the virus stays undetectable 12 weeks after fin…

Researchers are testing a new vaccine called LBVD that combines protection against diphtheria, tetanus, whooping cough, hepatitis B, polio, and Hib into a single injection. The study will enroll healthy infants aged 6 to 8 weeks, who will receive three doses at 6, 10, and 14 week…

This study tests an experimental drug called efinopegdutide in 80 adults with liver scarring (cirrhosis) caused by metabolic dysfunction-associated steatohepatitis (MASH), a type of fatty liver disease. The goal is to see if the drug can reduce liver fat, inflammation, and scarri…

This phase 2b trial tested whether saroglitazar magnesium can help people with nonalcoholic steatohepatitis (NASH) and liver fibrosis. 189 adults took either a 2 mg or 4 mg dose of the drug or a placebo daily for several months. The main goal was to see if the drug could resolve …

This early-stage trial is testing a drug called vixarelimab in 24 people with moderate to severe ulcerative colitis who have not improved with standard treatments. The study looks at how the drug affects the gut, how it moves through the body, and whether it is safe. It is too ea…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tests whether dapagliflozin, a drug currently used for diabetes, can help control inflammation in people with mild-to-moderate ulcerative colitis. Researchers will give 50 adults either dapagliflozin plus standard mesalamine or mesalamine alone, and track changes in sy…

This study tested a new once-weekly injection called UBT251 in 211 adults with type 2 diabetes. Participants received either UBT251, a placebo, or the existing drug semaglutide for 24 weeks. The main goal was to see how well UBT251 lowers blood sugar (HbA1c) and to find the right…

This phase 2 trial tests an experimental drug called XmAb20717 in 27 adults with advanced biliary tract cancers (bile duct or gallbladder cancer) that worsened after standard chemotherapy. The drug is a bispecific antibody designed to activate the immune system against cancer by …

This large study compares two diabetes drugs—oral semaglutide and sitagliptin—in over 25,000 people with type 2 diabetes and heart failure. Researchers want to see which drug better prevents heart failure worsening or death. The study uses existing medical records to mimic a clin…

This study tests an experimental tablet called ASC30 in 100 adults with type 2 diabetes. The goal is to see if it safely lowers blood sugar and helps with weight over 13 weeks compared to a placebo. Participants must have stable weight and a BMI of 23 or higher.

This study tested a new medicine called NNC0519-0130 in 299 adults with type 2 diabetes. The goal was to see if a once-weekly injection can lower blood sugar and body weight. Participants received up to 7 different doses for about 40 weeks. The results will help find the best dos…

This study tests a vaccine designed to help the immune system fight HPV-positive throat cancer. It is for patients who have completed surgery or chemoradiation and show no signs of cancer remaining. The trial will enroll 24 adults to find the safest and most effective dose by mea…

Researchers test whether fecal microbiota transplantation delivered by oral capsules can help cirrhosis patients whose hepatic encephalopathy no longer responds to standard lactulose and rifaximin. The trial enrolls 33 adults with cirrhosis and persistent or recurrent hepatic enc…

Researchers are testing an experimental oral drug called MBX-2982 in adults with type 2 diabetes. The trial compares three daily doses of MBX-2982 against a placebo and sitagliptin, a standard diabetes drug, over four weeks. Participants are treatment-naive or taking a single ora…

Researchers are testing whether a synbiotic supplement called SLP07 can reduce liver fat in people with metabolic dysfunction-associated fatty liver disease. The supplement combines probiotic bacteria, omega 3, and vitamin E. The trial enrolls 54 adults aged 50 and older who have…

Ulcerative colitis causes ongoing inflammation in the colon and rectum, and current treatments do not work for everyone. Researchers are testing whether adding pentoxifylline, a drug with anti-inflammatory and antioxidant effects, to standard care can reduce disease activity. The…

This study tested a smart cap that attaches to insulin pens to help people with type 1 diabetes track their injections and glucose data. 42 adults used the device or a blinded version for comparison. The goal was to see if it reduces time spent with high blood sugar and improves …

Researchers are testing whether a 24-month weight-loss program delivered by trained health coaches through an electronic medical record patient portal can help Black adults with obesity and type 2 diabetes or prediabetes. The study enrolls 352 people aged 40 to 70 in Louisiana pr…

Researchers test whether adding doxycycline to sitagliptin helps control blood sugar and heart health in adults over 40 with newly diagnosed type 2 diabetes. Participants receive both drugs, and the team tracks changes in fasting blood sugar and HbA1c. The trial also measures hea…

Researchers are testing whether adding fruquintinib to standard chemotherapy (mFOLFOX6 or FOLFIRI) helps people with metastatic colorectal cancer who have not yet received treatment for advanced disease. The trial enrolls adults up to age 75 with confirmed metastatic colorectal c…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

Researchers are testing whether combining cetuximab, a drug that blocks tumor growth, with stereotactic body radiation therapy can help patients whose head and neck cancer has returned after earlier radiation and cannot be removed by surgery. The trial enrolls about 45 people wit…

This study looks at the long-term safety of filgotinib, a drug for ulcerative colitis, in over 1,100 adults who already took part in a filgotinib trial. The main goal is to track side effects and lab test changes over time. Participants must have completed a prior filgotinib stud…

This early-phase trial tested two cancer drugs—imatinib mesylate and cyclophosphamide—given daily by mouth to 26 people with rare, advanced tumors that had no standard treatment. The main goal was to find the safest dose of imatinib when combined with a fixed dose of cyclophospha…

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This study tests a mobile app that sends personalized reminders to help older adults with diabetes manage their blood sugar, diet, and medications. 184 participants will either use the app or receive standard nurse consultations. The goal is to see if the app can improve diabetes…

Researchers are testing a 12-week low-fat, plant-based diet program delivered in a doctor's office. The program encourages whole grains, vegetables, legumes, and fruits, with no animal products or added oils, and no calorie counting. The study measures changes in weight, blood pr…

This study tested a drug called saroglitazar magnesium in 196 adults with primary biliary cholangitis (PBC), a chronic liver disease. Participants either took the drug or a placebo to see if it improved liver function markers. The goal was to lower certain liver enzymes and bilir…

This early-phase trial tests whether infusing specially grown donor-specific regulatory T cells (Tregs) can allow liver transplant recipients to safely reduce or stop their anti-rejection medications. Nine participants will receive a single dose of these cells and be monitored fo…

Researchers are testing whether a low-frequency high-intensity interval training (HIIT) program can reduce body fat and liver fat in adults with central obesity and non-alcoholic fatty liver disease. The trial enrolls 160 adults aged 18 to 60 who have a BMI of at least 25 and a l…

Researchers are testing whether continuous glucose monitoring, alone or combined with a family behavioral program, helps children under 8 with type 1 diabetes keep their blood sugar in a healthy range. The trial compares these approaches to standard home blood glucose monitoring.…

This study tests whether a cookie made from Golden Rice and red betel leaf can improve cholesterol and triglyceride levels in adults with type 2 diabetes. Over 28 days, 102 participants will eat the cookies daily, and their blood fat levels will be measured before and after. The …

This early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take pa…

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This study tests a mix of antibodies that help the immune system fight cancer, block tumor growth signals, and cut off the tumor's blood supply. It is for adults with head and neck cancer that did not respond to prior treatment or has no standard options. Participants receive inf…

This study looked at whether delivering healthy food to the homes of rural adults with type 2 diabetes and food insecurity could improve their blood sugar control and diet. Over 400 participants either received standard care alone or standard care plus free healthy food deliverie…

Researchers test whether a connected pillbox with pre-filled trays and automated text or phone reminders helps people with type 2 diabetes, high blood pressure, or high cholesterol take their medications as prescribed. The study enrolls about 50 adults who have struggled to stay …

This pilot study tests whether having a pharmacist oversee continuous glucose monitoring (using a FreeStyle Libre device) can improve blood sugar control and health behaviors in people with type 2 diabetes. Forty participants will use the monitor for 12 weeks, and their results w…

This early-stage study tests an experimental drug called MK-1403 in people with type 2 diabetes. The main goals are to check if the drug is safe and tolerable, and to see how it behaves in the body. Researchers will also measure its effect on a marker of inflammation (hsCRP). Abo…

This study tests a new drug called AHB-137 in 86 adults with chronic hepatitis B who are already on standard antiviral pills. The goal is to see if AHB-137 can clear the hepatitis B surface antigen from the blood, which would mean the virus is under control and patients might be …

This pilot trial tests whether a social media platform can provide continuous dietary and lifestyle support for women with gestational diabetes. Forty pregnant women diagnosed with gestational diabetes receive either usual care from a diabetes nurse and dietitian, or usual care p…

This study looks at how different exercise programs (moderate or high-intensity) and a diet plan affect appetite, blood sugar, and body fat in people with type 2 diabetes. About 146 adults will take part in a 12-week program. The goal is to find the best combination to improve he…

This phase 3 study tested a new once-daily pill called orforglipron against an existing oral semaglutide in nearly 1,700 adults with type 2 diabetes whose blood sugar was not well controlled on metformin. The main goal was to see how well orforglipron lowers blood sugar levels ov…

This study tests an experimental drug called NT-0796 in 176 obese adults, some with type 2 diabetes. Participants take the drug or a placebo alongside a reduced-calorie diet and increased physical activity for 6 months. The goal is to see if the drug helps with weight loss and re…

This study tested whether the drug ritlecitinib could prevent intestinal damage and symptoms when people with celiac disease ate gluten. 62 adults with well-controlled celiac disease (on a gluten-free diet) took either the drug or a placebo along with a daily gluten challenge. Th…

Researchers compare three weekly GLP-1 receptor agonists, dulaglutide, semaglutide, and tirzepatide, in 159 obese adults, 84 with diabetes and 75 without. Participants receive one of the drugs for 24 weeks. The trial measures changes in body weight, BMI, blood sugar, cholesterol,…

Researchers test whether adding high-dose radiotherapy to standard chemoembolization slows tumor growth better than chemoembolization alone in adults with hepatocellular carcinoma. Participants have liver tumors up to 9 cm that cannot be removed by surgery or treated with percuta…

Researchers test whether continuous glucose monitors (CGM) can help hospitalized adults with type 2 diabetes reach a tighter average blood sugar target of 90 to 130 mg/dL without causing dangerous low blood sugar. Participants are randomly assigned to standard care (target 140 to…

Researchers are testing whether atorvastatin, a widely used cholesterol drug, can reduce complications in people with decompensated liver cirrhosis. The trial enrolls 100 adults aged 18 to 75 who have had at least one serious cirrhosis complication, such as ascites, jaundice, or …

This study tested a drug called CC-93538 (Cendakimab) in 48 Japanese adults and adolescents with eosinophilic gastroenteritis, a condition where certain white blood cells build up in the digestive tract causing pain and other symptoms. The trial was randomized and placebo-control…

This study tests whether adding tiragolumab to atezolizumab can help control esophageal cancer that hasn't grown after standard chemoradiotherapy. About 760 adults with inoperable esophageal squamous cell carcinoma will receive either the drug combination, atezolizumab alone, or …

This study tests whether combining a shared decision-making checklist during doctor visits with mobile text reminders helps people with type 2 diabetes take their medications as prescribed. About 378 patients from community health centers in Michigan are taking part. The goal is …

Researchers at Nantes University Hospital are testing a computer model that describes how glucose and insulin interact in people with type 1 diabetes. The model aims to help doctors choose insulin pump settings, including basal rate, insulin sensitivity, and carbohydrate ratios. …

This early-phase trial tests a new drug called AI-061, which combines two immune-boosting antibodies (anti-PD-1 and anti-CTLA-4) into one treatment. The study will enroll 18 adults with advanced solid tumors that have spread or cannot be removed. The main goals are to find a safe…

This study tests a combination of two drugs, abemaciclib and ramucirumab, in people with advanced esophageal or gastroesophageal junction cancer that has spread. The goal is to see if this treatment is safe and can help control tumor growth. About 8 participants are enrolled, and…

Severe acute pancreatitis causes the pancreas to swell dangerously, and pressure building inside the abdomen can lead to organ failure. Researchers at a Shanghai hospital are testing whether adding Da-Cheng-Qi Decoction, a classic Chinese herbal formula, to standard Western treat…

This early-stage trial is testing a new drug called tuvusertib, given together with either lartesertib or avelumab, in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see how the body pr…

Researchers are testing whether regorafenib, a daily oral drug, works as well as standard combination chemotherapy for people with newly diagnosed metastatic colorectal cancer. The trial enrolls adults with good performance status who have not yet received treatment for metastati…

This early study is testing a new magnetic device that creates a shortcut in the digestive system to help people with obesity and type 2 diabetes lose weight and control blood sugar. Ten adults aged 18-65 with a BMI between 30 and 35 will have the device placed using a scope, wit…

Researchers are testing lurbinectedin, an intravenous chemotherapy drug, in adults with advanced gastrointestinal cancers that carry mutations in DNA repair genes. The trial enrolls a small group of participants whose tumors are locally advanced or metastatic and who have specifi…

This study tests a new magnetic system (MagDI) that creates a connection between two parts of the small intestine to help with weight loss and blood sugar control. It involves 25 adults with obesity and type 2 diabetes. The goal is to see if the device is safe, works as intended,…

This Phase 2 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve kidney health in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat and b…

Researchers test a blood purification device called Efferon CT combined with high-volume hemofiltration in adults with acute pancreatitis. The goal is to see if removing inflammatory molecules from the blood reduces organ dysfunction and improves recovery. The trial enrolls 28 pa…

Researchers are testing whether allopurinol can interfere with the processes that lead to hepatic decompensation, a serious complication of cirrhosis. The trial enrolls 100 adults aged 18 to 75 with cirrhosis. Participants receive either allopurinol tablets or a placebo, and rese…

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

This study tests whether adding an immunotherapy drug (atezolizumab) to standard chemotherapy and targeted therapy (trastuzumab) can better shrink HER2-positive stomach or gastroesophageal junction cancer before surgery. About 42 adults with advanced but removable tumors will rec…

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

This completed Phase 1 study tested a new fast-acting insulin called NNC0471-0119 in 43 adults with type 1 diabetes who use an insulin pump. The goal was to see how quickly the insulin enters the bloodstream, how long it works, and how safe it is compared to a standard insulin (i…

Researchers are testing whether adding an SGLT2 inhibitor to the usual treatment for type 2 diabetes improves blood sugar control and other metabolic measures. The trial enrolls about 482 adults with type 2 diabetes who are not already taking these drugs. Participants will be com…

This study tests whether giving doctors a reminder and providing patients with a one-page handout can help women who had gestational diabetes or high blood pressure during pregnancy get a primary care visit within six months of delivery. The goal is to prevent future diabetes and…

This study tested a once-daily pill called ABX464 (obefazimod) in 639 people with moderate-to-severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could help bring about remission and improve bowel inflammation within 8 weeks. …

This study tests whether giving oral zinc sulfate and ursodeoxycholic acid alongside standard light therapy can help clear jaundice faster in newborns. About 80 babies with non-hemolytic jaundice will receive one of two doses of zinc, or the liver drug UDCA, plus phototherapy. Th…

This study tested a new daily pill, ABX464, for people with moderate to severe ulcerative colitis who did not get better with other treatments. About 636 adults and teens took either 25 mg, 50 mg, or a placebo for 8 weeks. The main goal was to see if the drug could help achieve r…

This Phase 2 trial tests a once-weekly injection called petrelintide in 221 people with overweight or obesity and type 2 diabetes. Participants receive either petrelintide or a placebo for several weeks. The main goal is to see how much weight they lose and whether blood sugar im…

This study tested a new investigational medicine called CagriSema, which combines two drugs (cagrilintide and semaglutide) in one weekly injection. It was given to 274 adults with type 2 diabetes who were already taking daily insulin, with or without metformin. The goal was to se…

This study tested two ways to offer HIV treatment, hepatitis C treatment, and substance use disorder medications to people who inject drugs. One group received a telehealth-enhanced program with on-demand services like mobile blood draws and counseling, while the other group got …

This study tests a new investigational medicine called CagriSema against an approved drug, tirzepatide, in people with type 2 diabetes whose blood sugar is not well controlled by current pills. About 1,023 adults will receive either CagriSema or tirzepatide once a week for up to …

Researchers are testing an experimental drug called MRG003 in adults with biliary tract cancer that is EGFR-positive and cannot be removed by surgery or has spread. The trial enrolls people whose cancer worsened after at least one standard treatment. Everyone receives MRG003 by i…

This phase 2 trial tests whether simvastatin, a widely used cholesterol-lowering drug, can prevent liver cancer in 52 adults with liver cirrhosis. Participants take simvastatin and are monitored with blood tests and imaging to see if cancer-related markers change. The goal is to …

Researchers are testing whether lanifibranor, a drug for fatty liver disease, can improve blood sugar control in adults with NASH and type 2 diabetes. They are also studying whether combining lanifibranor with empagliflozin, a diabetes medication, works better than lanifibranor a…

This early-phase study tests a new drug called AB680, combined with immunotherapy (zimberelimab) and two chemotherapy drugs (nab-paclitaxel and gemcitabine), in people with advanced pancreatic cancer that has spread. The main goals are to check safety and find the right dose. Abo…

Researchers test whether shared decision making helps adults with type 2 diabetes who have poor blood sugar control. Participants are randomly assigned to receive either shared decision making sessions or routine health education. The trial measures changes in self-efficacy, heal…

This phase 2 trial tests whether adding an experimental drug called pixatimod to the immunotherapy nivolumab can shrink tumors in people with advanced melanoma, non-small cell lung cancer, or colorectal cancer that has stopped responding to prior treatment. One group with colorec…

This phase 2 trial tests whether peginterferon lambda, an experimental interferon drug, can safely reduce hepatitis D virus levels in people with chronic infection. Participants receive one of two doses of the drug for 48 weeks, and researchers measure changes in viral load and l…

This study tests the long-term safety and effectiveness of a weekly injection called glepaglutide in adults with short bowel syndrome, a condition where the body cannot absorb nutrients properly. Participants who completed a previous trial will receive the drug for about 2 years.…

This completed trial tested whether a faster-acting insulin (Lyumjev) used with a special conversion factor in an automated insulin pump (Control-IQ) could improve blood sugar control in 11 adolescents with type 1 diabetes. Participants were randomly assigned to use Lyumjev with …

This study tested whether a short period of intensive insulin therapy, followed by a combination of basal insulin, metformin, and vildagliptin, could help people with poorly controlled type 2 diabetes simplify their long-term treatment. The goal was to see if more participants co…

This trial tests whether 8 weeks of home-based exercise can improve physical fitness, muscle strength, and quality of life in adults with chronic liver disease. Participants are split into three groups: aerobic exercise, aerobic plus resistance exercise, or a control group receiv…

This phase 3 trial tests the long-term safety of glepaglutide, a drug that mimics a natural gut hormone, in 145 adults with short bowel syndrome. The goal is to see if it can safely help the gut absorb more nutrients, potentially reducing the need for intravenous feeding. Partici…

This phase 2 trial tests whether a natural vitamin E supplement called tocotrienol can slow the worsening of end-stage liver disease. Seventy adults with stable but advanced liver disease (MELD score 8–17) will take either tocotrienol or a placebo twice daily for three years. The…

This pilot study tested a wearable device that delivers low-intensity electric fields (TTFields) together with immunotherapy (atezolizumab) and two chemotherapy drugs (gemcitabine and nab-paclitaxel) in 84 people with metastatic pancreatic cancer who had not received prior treatm…

This phase 3 study tested an experimental once-daily pill called orforglipron (LY3502970) against a placebo in 1613 adults who are overweight or have obesity and type 2 diabetes. The goal was to see if the drug helps with weight loss and improves blood sugar control. Participants…

This phase II trial tests whether giving chemotherapy and proton beam radiation before surgery can help people with borderline-resectable pancreatic cancer. The goal is to shrink the tumor enough so that surgeons can remove it completely, with no cancer cells left at the edges. P…

This study tested a new investigational drug called CagriSema against a currently available medicine, tirzepatide, in over 1,000 adults with type 2 diabetes. The goal was to see which works better at lowering blood sugar and body weight. Participants received weekly injections of…

This Phase 2 trial tested whether oral cimetidine (Tagamet), a common heartburn drug, can reduce light sensitivity in people with erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP). These genetic conditions cause severe pain from sunlight exposure. The study en…

This study tests a decision model that aims to predict whether a person with unresectable hepatocellular carcinoma, a type of liver cancer, will benefit more from transarterial chemoembolization (TACE) alone or TACE combined with atezolizumab plus bevacizumab. Researchers will de…

This study tests whether tailored vitamin and mineral supplements can correct nutrient deficiencies that often follow surgery for esophageal or gastric cancer. Researchers will enroll 107 adults who had either an esophagectomy or a (sub-)total gastrectomy for cancer and show no s…

This study tests whether choosing diabetes medications based on a person's genetic profile helps control blood sugar better than standard treatment. About 500 adults with type 2 diabetes that is not well controlled will be randomly assigned to either gene-guided or standard care.…

This study tests whether giving higher doses of radiation, guided by MRI, can help people with pancreatic cancer that cannot be removed by surgery. Participants must have already had several months of chemotherapy without the cancer spreading. The goal is to see if this approach …

This study looked at the long-term safety and effectiveness of a drug called A4250 (odevixibat) in 116 children with progressive familial intrahepatic cholestasis (PFIC), a rare liver disease. The children took the drug for up to 72 weeks. The study measured changes in bile acid …

This early-stage trial tests an investigational drug called MWN105, given as an injection under the skin, in healthy Chinese volunteers aged 18 to 45. The study aims to check the drug's safety, how the body processes it, and whether it triggers an immune response. Researchers wil…

This phase 3 study tests whether a new combination of two immunotherapy drugs (domvanalimab and zimberelimab) plus chemotherapy works better than the current standard (nivolumab plus chemotherapy) for people with advanced stomach, gastroesophageal junction, or esophageal cancer t…

This study tests two treatments for people with repeat C. diff infections: a lab-made bacteria mix called MTC01 and a fecal transplant (FMT) from a healthy donor. Both are given during a colonoscopy. The goal is to see which is safer and better at stopping the infection from comi…

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take th…

This trial tests an oral medication called MWN109 in Chinese adults with type 2 diabetes, overweight, or obesity. Researchers want to see if the amount of water taken with the pill and the timing of the next meal change how much drug enters the blood. The study also checks safety…

This study tested whether adding a Chinese herbal formula (QingyiHuaji) to standard chemotherapy helps people with stage IV pancreatic cancer live longer. About 305 adults with advanced pancreatic cancer were randomly assigned to receive either the herbal formula plus chemo or a …

This trial tests an experimental drug called FLX475, given alone or with the immunotherapy pembrolizumab, in people with advanced cancers that have not responded to standard treatments. The study aims to find the safest dose and to see whether the combination can shrink tumors. P…

This study tested a once-daily pill called orforglipron in 559 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The pill was compared to a placebo (a dummy pill) over about 54 weeks to see if it safely lowers blood sugar levels. Th…

This pilot study tests whether injecting a corticosteroid called dexamethasone directly into the salivary glands can prevent dry mouth in people receiving radiation therapy for head and neck cancer. Researchers will enroll 10 adults with certain types of throat cancer who are sch…

This study looks at whether the amount of effort you put into strength training can improve blood sugar control and mental health in people with type 2 diabetes. About 48 adults with type 2 diabetes will do resistance exercises at different effort levels. Researchers will track b…

This phase II trial tests whether combining niraparib and dostarlimab can control metastatic pancreatic cancer in people who carry BRCA1/2 or PALB2 gene mutations. Niraparib blocks enzymes that cancer cells need to grow, while dostarlimab helps the immune system attack the tumor.…

This study looks at whether eating a high-fiber diet (over 21 grams per day) can change gut bacteria and improve the immune system's ability to fight solid tumors like colorectal cancer. About 25 adults with solid tumors will follow this diet to see if it is safe and helps with t…

This trial tests an experimental drug called zanidatamab, which targets HER2, a protein that fuels certain breast and stomach cancers. Researchers give zanidatamab alongside chemotherapy, and sometimes with the immunotherapy tislelizumab, to people with advanced HER2-positive bre…

This trial tests whether adding a Braun anastomosis, an extra connection between two parts of the small intestine, during standard pancreatic surgery helps prevent delayed gastric emptying. Delayed gastric emptying is a common complication where the stomach is slow to empty food,…

This early-phase trial tests a combination of two immunotherapy drugs (nivolumab and ipilimumab), a vaccine targeting TGFβ-15, and targeted radiation for pancreatic cancer that has not responded to standard treatments. The goal is to see if this mix can safely boost the immune sy…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This early trial tests montbretin A, a compound extracted from crocosmia plant bulbs, in people with type 2 diabetes and in healthy volunteers. The main goal is to find a safe dose and see if it causes fewer stomach side effects than standard diabetes medications. Participants ta…

This trial tests whether adding Lonsurf (trifluridine/tipiracil) to standard chemotherapy can help control metastatic colorectal cancer. Researchers will enroll about 97 adults in Taiwan whose cancer has progressed after prior treatments, including anti-VEGF therapy. Participants…

This study tests whether adding empagliflozin or semaglutide to insulin can improve blood sugar control in overweight or obese adults with type 1 diabetes. About 105 participants will take one of the two drugs or a placebo for 3 months. The goal is to see if these drugs help lowe…

This Phase 3 trial tested whether adding the immunotherapy drug retifanlimab to standard chemotherapy (carboplatin and paclitaxel) helps people with advanced anal cancer that cannot be removed by surgery. The study enrolled 308 adults who had not received chemotherapy for their a…

This trial tests an experimental drug called SNS-101, which targets a protein called VISTA that may help tumors evade the immune system. Researchers give SNS-101 alone or with another immunotherapy, cemiplimab, to adults with advanced solid tumors that have not responded to stand…

This trial tests whether combining the immunotherapy drug atezolizumab with precise, high-dose radiation (SABR) can better control metastatic cancers, including colorectal, lung, kidney, and sarcoma. The idea is that radiation may make tumors more visible to the immune system, wh…

This trial tests two popular diets for irritable bowel syndrome (IBS) in Turkish adults. Researchers will compare a 4-week low-FODMAP diet, which limits certain fermentable carbs, against a 4-week gluten-free diet. Seventy people with IBS will follow one of the diets under a diet…

This study tested whether providing medically tailored meals (10 ready-to-eat meals per week for 6 months) plus phone-based lifestyle coaching could improve blood sugar control in adults with type 2 diabetes who also face food insecurity. 215 participants were randomly assigned t…

This early study tests a small, permanent device called the Omega-Cuff in 8 adults with GERD. Placed around the weak esophageal sphincter during keyhole surgery, it aims to block acid from backing up while allowing food to pass normally. Researchers will check safety, acid levels…

This study tested an experimental drug called RZ402 in 94 people with diabetic macular edema, a condition that causes vision loss in people with diabetes. The goal was to see if the drug is safe and can reduce swelling in the retina and improve eyesight compared to a placebo. Par…

This study tested a 4-month online program that encourages a very low-carbohydrate breakfast for adults with poorly controlled type 2 diabetes. Researchers measured how satisfied participants were, how well they stuck to the diet, and changes in blood sugar, weight, and medicatio…

This trial tests whether an oral antibiotic called tebipenem-pivoxil works as well as the standard IV antibiotic ceftriaxone for children with shigellosis, a severe diarrheal disease, when first-line treatment fails. The study enrolls children aged 24 to 59 months who have not im…

This study tested two different treatment plans for people with a specific type of pancreatic cancer that is on the edge of being removable by surgery. 130 patients received either chemotherapy alone or chemotherapy plus radiation before surgery. The goal was to see which approac…

This trial tests whether tulisokibart, an experimental drug given by IV infusion, can help people with moderate to severe ulcerative colitis achieve remission. About 178 participants will receive either tulisokibart or a placebo for 12 weeks, with the option to continue treatment…

This study tests whether giving probiotics to pregnant women with diabetes can improve their babies' brain development. Researchers will give 60 mothers a probiotic supplement and then measure their infants' brain responses to sounds and sights at 1 and 6 months old. The goal is …

This study tests whether adding culturally tailored heart-health education to medically tailored meal programs helps people with type 2 diabetes and high blood pressure eat better and improve their blood sugar and blood pressure. About 176 adults from low-income New York City nei…

This phase 2 study is testing a combination of three drugs—paclitaxel (a chemotherapy), pembrolizumab (an immunotherapy), and olaparib (a targeted therapy)—in 36 adults with advanced gastric or gastroesophageal cancer that has worsened after one prior treatment. The goal is to se…

This study is checking how safe and effective an updated insulin pump system (Control-IQ 1.5) is for children ages 2 to 6 with type 1 diabetes. About 144 kids will use the pump for a year while researchers track dangerous low blood sugar events and diabetic ketoacidosis. The goal…

This phase 3 trial compares two steroid schedules for severe alcohol-associated hepatitis, a serious liver condition with high death rates. One group takes prednisolone for 7 days followed by a placebo for 7 days, while the other takes prednisolone for the full 14 days. Researche…

This Phase 2 trial tests a new way of delivering radiation therapy (SIB-IMRT) together with standard chemotherapy (5-FU and Mitomycin-C) for people with locally advanced anal cancer. The goal is to see if this approach can improve tumor control and reduce the severe side effects …

This pilot study tests a 12-week text message program called AYUDA for younger Latinx adults recently diagnosed with type 2 diabetes who are also caring for a child. Participants receive twice-weekly texts with diabetes education and self-management resources. Researchers compare…

This trial asks whether eating tinned mackerel twice a week can improve blood sugar control in South Asian adults with type 2 diabetes. Participants with diabetes will either keep their usual diet or replace some red meat or poultry with mackerel for 16 weeks. Researchers will me…

This study looks at whether it's possible to increase fiber intake in people with colorectal cancer before they have surgery. Researchers will compare personalized digital dietary advice, a dried vegetable product, and usual diet in 54 participants. The goal is to see if fiber in…

Researchers at the University of Aberdeen are testing whether a buckwheat beverage can reduce blood sugar spikes after meals. The study includes healthy adults and people with type 2 diabetes whose condition is managed by diet or metformin. Participants drink the beverage and hav…

This study tests a new insulin infusion set designed to last up to 7 days for people with type 1 diabetes. Twenty adults currently using a Tandem insulin pump and Dexcom CGM will try the SteadiSet at home. The goal is to see if the set can survive a full week without causing high…

This phase 1 trial tests an experimental drug called MRG003 in people with advanced solid tumors, including colorectal cancer, head and neck squamous cell carcinoma, and nasopharyngeal carcinoma. The study aims to find a safe dose and to see whether the drug can shrink tumors. Pa…

This trial tests whether an essential amino acid supplement can lower fat stored in the liver of teenagers with non-alcoholic fatty liver disease (NAFLD). Participants aged 13 to 18 will take the supplement or a placebo for two months, and researchers will measure liver fat with …

This study tests whether avatrombopag, a pill that boosts platelet production, can help people with gastrointestinal cancer who develop low platelets from chemotherapy. About 60 participants will receive either avatrombopag or a placebo. The goal is to see if the drug can raise p…

This trial tests whether personalized education, guided by a risk assessment for six major diabetes complications, can improve blood sugar control in adults with type 2 diabetes. Participants receive education focused on their highest predicted risk, such as kidney disease or str…

This trial tests a multimodal program for adults aged 65 and older with type 2 diabetes who are frail or prefrail. The program combines a 16-week exercise routine, educational sessions on diabetes self-care, and adjusted blood sugar and blood pressure goals. Researchers compare t…

This trial tests whether eating freeze-dried strawberry powder daily for four weeks can lower chronic inflammation and improve blood vessel function and insulin sensitivity in adults with prediabetes. Participants will be randomly assigned to receive either a low dose, a high dos…

This trial tests two medicines, nitazoxanide and metronidazole, to see which works better for diarrhea caused by Entamoeba histolytica in children. About 90 children aged 2 to 15 with confirmed amoeba infection will be randomly assigned to one of the two drugs. Nitazoxanide is gi…

This trial tests whether a 12-week program of aerobic and resistance exercises can help people with gastrointestinal cancer and cachexia, a condition marked by severe weight and muscle loss. Researchers will compare an exercise group with a standard-care group, measuring changes …

Many adults with type 1 diabetes don't get enough sleep, which can make blood sugar harder to control. This trial tests a 12-week program called Sleep-Opt that uses wearable sleep trackers, phone coaching, and educational materials to improve sleep habits. Researchers will measur…

This trial tests whether a daily 10-gram dose of sea buckthorn extract, taken for 12 weeks, can improve blood sugar control and immune cell balance in adults with type 1 diabetes. Type 1 diabetes is an autoimmune condition where the body attacks insulin-producing cells. The study…

This trial compares two timings for closing a temporary ileostomy after bowel surgery: early (within 8 weeks) versus delayed (after 8 weeks). The goal is to see which approach leads to a shorter post-operative hospital stay. Adults aged 18-65 with a temporary ileostomy scheduled …

This phase 2 trial is testing an experimental drug called HTD1801 (BUDCA) in adults with primary biliary cholangitis (PBC) who haven't responded adequately to standard treatment. The goal is to see if the drug can safely lower alkaline phosphatase (ALP) levels, a key marker of li…

This phase III trial is investigating whether adding heated chemotherapy (HIPEC) to standard surgery improves survival for people with advanced stomach cancer. Participants are randomly assigned to receive either surgery alone or surgery plus HIPEC, where a heated chemotherapy so…

This trial investigates whether high-intensity interval training (HIIT) can improve how the body uses insulin in obese adults with glucose intolerance. Participants will be assigned to either HIIT (short bursts of intense exercise) or moderate-intensity continuous training (MICT,…

This study tests a telehealth program called REAL-T, designed to help young adults with type 1 diabetes fit diabetes care into their daily habits and routines. Participants receive about 12 hours of virtual coaching from an occupational therapist over six months. The study compar…

This trial is testing whether a chemotherapy drug called idarubicin works as well as the standard drug doxorubicin when used in a procedure called transarterial chemoembolization (TACE) for liver cancer. TACE delivers chemotherapy directly to the tumor and blocks its blood supply…

This trial explores whether it is possible to run a larger study of mirtazapine, an antidepressant, in people who have both major depression and inflammatory bowel disease (IBD). About 76 adults with IBD and depression will be randomly assigned to take either mirtazapine or a pla…

This trial tests whether the type of IV fluid given to people with acute pancreatitis affects how severe the disease becomes. About 800 adults with acute pancreatitis will be randomly assigned to receive either lactated Ringer's solution or normal saline for at least 48 hours. Th…

This trial is testing whether adding anakinra, a drug used for arthritis, to standard chemoradiotherapy is safe for people with rectal cancer. The study will include about 12 patients and will use a dose-escalation design to find the highest tolerable dose of capecitabine when co…

This Phase 3 trial is testing whether a once-daily 50 mg semaglutide tablet can help East Asian adults with overweight or obesity lose weight. Participants will take either the active tablet or a placebo for 68 weeks, alongside lifestyle counseling on diet and physical activity. …

This study tests whether a supplement made from brown algae and chromium picolinate, when added to a calorie-controlled Mediterranean diet, can reduce fat buildup in the liver. Adults with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic syndrome wil…

This phase II trial is investigating whether giving the drug bevacizumab directly into the liver's main artery, alongside standard chemotherapy, can shrink liver tumors in people with colorectal cancer that has spread only to the liver. The study enrolls patients whose cancer pro…

This trial tests whether a prebiotic fiber from chicory, called fructans, can improve bowel habits in young children aged 1 to 3 with constipation. Half of the 100 participants will receive the prebiotic daily for four weeks, while the other half gets a placebo. Parents will trac…

This trial tests an experimental oral drug called HTD1801 in adults with nonalcoholic steatohepatitis (NASH), a serious liver condition, along with liver fibrosis and type 2 diabetes or prediabetes. Participants receive either HTD1801 or a placebo to see if the drug can improve l…

This trial tests whether combining a 12-herb traditional Chinese medicine formula with plant-derived probiotics can improve symptoms of slow transit constipation, a condition where the colon moves stool too slowly. About 120 adults with this condition will be randomly assigned to…

This trial tests a smart insulin pump algorithm designed to automatically adjust insulin delivery during the night to keep blood sugar levels in a safe range. The algorithm predicts when blood sugar might drop too low and pauses insulin, and when it might rise too high, it gives …

This trial investigates whether a traditional herbal drug, NOSHIN SHAHD, can improve insulin resistance and reduce inflammation and oxidative stress in people with type 2 diabetes. Participants will take the herbal drug or a placebo for about six weeks, and researchers will measu…

This registry follows thousands of adults who undergo laparoscopic surgery for gastroesophageal reflux disease (GERD) or hiatal hernia. It compares two common procedures: fundoplication, which wraps part of the stomach around the esophagus to reinforce the valve, and the LINX dev…

This trial tests whether a 12-week calorie-restricted diet, combined with the weight-management drug Contrave, can help people with type 2 diabetes and obesity achieve remission. Remission means blood sugar levels drop below the diabetes threshold without needing glucose-lowering…

This trial tests whether a digital clinic, delivered through a smartphone app, can improve health outcomes for people with alcohol-associated liver disease (ALD) and alcohol use disorder (AUD). Participants' doctors are randomly assigned to refer them to this digital platform in …

This trial is testing whether a prebiotic supplement called 2'-FL, found in human milk, can safely ease gut symptoms in young people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Participants, aged 11 to 25, are in remission and already …

This trial asks whether cooking with refined high-oleic palm oil can improve cholesterol and blood sugar levels as effectively as olive oil. Healthy adults will be randomly assigned to use one of the two oils in their daily cooking for four months. Researchers will measure change…

This study follows about 600 adults with Crohn's disease who are receiving ustekinumab (Stelara) as part of their routine care. The goal is to see how many achieve steroid-free remission after one year, using a standard symptom score. By including patients from both large researc…

This trial is testing whether adding an experimental antibody called XB2001 to a standard chemotherapy regimen can help people with advanced pancreatic cancer. The study has two parts: first, it finds the safest dose of XB2001, then it compares the antibody plus chemo against a p…

This trial investigates whether combining two laparoscopic procedures—resection rectopexy and sacrocolpopexy—can safely and effectively treat women who have both pelvic organ prolapse and obstructive defecation syndrome (a type of chronic constipation). The study will enroll 35 w…

This trial tests whether epidural analgesia—pain medicine delivered near the spinal cord—can help people with severe acute pancreatitis breathe better and avoid needing a breathing machine. About 148 ICU patients with severe pancreatitis will be randomly assigned to receive eithe…

This trial tests whether a smartphone app called Kiplin, which uses games, telecoaching, and social support, can increase daily physical activity in people with obesity or type 2 diabetes. It compares the app to a standard three-month face-to-face exercise program. The main goal …

This trial tests whether a specially designed mealtime insulin, HDV-insulin lispro, can reduce nighttime low blood sugar (hypoglycemia) in adults with type 1 diabetes. Participants will use continuous glucose monitors and work with doctors to adjust doses. One group receives the …

This trial investigates whether drinking pomegranate juice for 12 weeks can reduce gut inflammation in people with Crohn's disease or ulcerative colitis who are in remission. Participants will drink either pomegranate juice or a placebo beverage twice daily, and researchers will …

This trial tests whether time-restricted eating (TRE) — limiting all food intake to an 8-10 hour daily window — can improve blood sugar control and metabolic health in people with metabolic syndrome or prediabetes. Participants are randomly assigned to either standard nutritional…

This trial is testing a personalized treatment for people with inoperable perihilar cholangiocarcinoma, a type of bile duct cancer. The approach combines radiofrequency ablation — using heat to destroy tumor tissue — with complete drainage of bile ducts, guided by both endoscopy …

Researchers are studying whether small intestinal bacterial overgrowth (SIBO) is common in people with abdominal bloating or distension. Adults aged 18 to 70 with these symptoms take a breath test that measures hydrogen and methane in their exhaled air. The study aims to see how …

People with cystic fibrosis often develop prediabetes and then diabetes, but doctors lack a good way to predict who will progress. This pilot study at Indiana University tests whether a continuous glucose monitor worn for up to 10 days, combined with a mathematical model called t…

Researchers are studying whether PET scans help doctors plan radiation more precisely for people with locally advanced head and neck cancer. Participants receive 3-dimensional conformal radiation therapy and intensity-modulated radiation therapy, which shape beams to the tumor. T…

This study tests whether a sound-wave technique called shear wave elastography, performed during a standard upper endoscopy, can measure liver and spleen stiffness and grade liver fibrosis. Participants are adults with known or suspected cirrhosis who are already scheduled for an…

Researchers are evaluating four blood glucose meters and four HbA1c point-of-care devices to see how accurately they measure blood sugar and long-term glucose control compared with standard lab methods. The study includes people with diabetes, both adults and teenagers, some of w…

Researchers in Senegal are testing a new way to care for children under 15 who come to primary health clinics with fever or diarrhea. The strategy combines rapid tests for malaria, dengue, and strep A with a digital tool that suggests treatment based on symptoms and test results.…

Researchers in Georgia are testing whether mailing hepatitis C self-tests to people who inject drugs and men who have sex with men increases how many get tested. The trial enrolls 1,250 adults in Tbilisi and Batumi who do not know their hepatitis C status. Half receive a self-tes…

Researchers in Karachi, Pakistan, are studying whether delivering hepatitis C self-tests to people's homes increases how many get tested. The trial enrolls about 2,000 adults who live in two areas of the Malir district and have not recently been tested. Half receive a self-test k…

Researchers are testing whether giving people in Malaysia a rapid hepatitis C self-test kit to use at home increases how many get tested, compared with standard clinic-based testing. The trial enrolls 750 adults who are not known to have hepatitis C and have not been tested in th…

Researchers at Hanoi Medical University are studying whether two blood markers, AFP-L3 and PIVKA-II, can accurately detect hepatocellular carcinoma, the most common form of liver cancer. The trial enrolls 200 adults, including people with liver cancer and people with benign liver…

Researchers at ETH Zurich are testing whether analyzing exhaled breath can diagnose lactose intolerance. The study includes 112 adults aged 18 to 65 in the Zurich area who consume a lactose or glucose solution. By measuring specific gases in the breath and comparing them to urine…

Researchers are testing the Liver Incyte system, an ultrasound device that measures how stiff the liver is, to see if it can tell healthy people apart from those with liver fibrosis or steatosis. The trial includes 140 adults, some healthy and some with a history of hepatitis C o…

Researchers are testing a device called Glyconics-DS that shines near-infrared light on a fingernail to measure glycated keratin, a marker linked to blood sugar. The trial enrolls about 486 adults who do not know their diabetes status and compares the scan result with a standard …

Researchers are testing whether a fluorescent dye called cRGD-ZW800-1 can help surgeons see oral cancer tumors more clearly during surgery. The trial enrolls adults with squamous cell carcinoma of the mouth who are scheduled for tumor removal. Participants receive an injection of…

Researchers test a two-step PET scan to find colorectal cancer that has spread to the liver or other organs. The scan uses an antibody that sticks to a protein called CEA on cancer cells, then a radioactive peptide that lights up those cells. Adults with colorectal cancer that ma…

This pilot study explores whether three different home sleep apnea testing devices—NightOwl, SleepImage, and Nox T3—are practical and user-friendly for adults with type 2 diabetes. Participants will wear each device at home for three nights and answer questionnaires about their e…

Researchers at Washington State University are testing whether tailored digital messages can increase colorectal cancer screening among American Indian and Alaska Native adults aged 50 to 75. The trial compares screening rates between people who receive the messages and those who…

This completed trial tested whether a 3D imaging device helps doctors more accurately classify colon polyps and adenomas during colonoscopy compared to standard 2D imaging. 460 adults with colorectal polyps were randomly assigned to either 3D or 2D imaging before polyp removal. T…

This study looked at whether a new at-home stool DNA test (Cologuard) can help more Alaska Native people get screened for colorectal cancer, which is very common in this group. About 2,000 Alaska Native adults who were due for screening took part. The test was offered in differen…

Researchers at Assiut University are investigating whether the ratio of two blood proteins, fibrinogen and albumin, is linked to diabetic kidney disease in people with type 2 diabetes. The study compares 50 patients who have both type 2 diabetes and kidney disease with 50 patient…

This trial tests a blood-based test designed to detect multiple cancers early in people aged 40 to 74 who have no cancer symptoms. The study will enroll about 2,500 participants and will check how well the test identifies lung, colorectal, liver, gastric, and esophageal cancers. …

Researchers are comparing three bedside scoring systems, the Alvarado, AIR, and AAS, to see which one most accurately identifies acute appendicitis in adults. The study reviews records of 300 emergency patients who had their appendix removed due to suspected appendicitis. Each pa…

This study tests whether a combination of serial C-reactive protein blood tests and targeted CT scans can safely identify which rectal cancer patients can skip a temporary ileostomy after laparoscopic low anterior resection. Anastomotic leakage is a serious complication, and a pr…

This trial tests whether indocyanine green, a dye injected before surgery, can find sentinel lymph nodes as reliably as the standard technetium-99 radioactive tracer. About 744 adults with various cancers will receive both agents, and surgeons will compare detection rates using a…

This completed study tested whether artificial intelligence (AI) can detect systemic diseases, like liver problems, by analyzing eye images. Researchers trained a deep learning model on eye photos from 775 participants. The goal was to see if the AI could spot signs of disease th…

This study tests whether chemicals in a person's breath, called volatile organic compounds, can signal inflammation in inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. Researchers will collect breath, blood, and stool samples from people wi…

This study tests a new, less invasive way to measure stomach acid using a small wireless capsule (SmartPill) that patients swallow. It compares the capsule's accuracy to the standard method, which involves a tube placed through the nose into the stomach. The study includes health…

This pilot trial tests whether a new non-invasive device called Gastric Alimetry, which records stomach muscle activity through skin electrodes, can guide treatment for people with suspected gastroparesis better than the standard gastric emptying scan. Researchers will compare ma…

This trial tests a device that uses a laser to scan the inside of the mouth and help detect pre-cancer and cancer. Currently, doctors rely on their eyes to decide where to take a biopsy, which can miss early signs. The device collects molecular information from the tissue, and th…

This study follows people with a significantly elevated risk of pancreatic cancer—due to inherited gene mutations or strong family history—who choose to undergo early detection testing. Participants receive endoscopic ultrasound (EUS) and MRI scans on an alternating schedule ever…

This trial evaluates a new biopsy needle (Micro-Tech FNB) used during endoscopic ultrasound to collect tissue samples from suspected pancreatic tumors. The goal is to see if this needle provides accurate diagnoses and yields enough high-quality tissue for genetic sequencing, whic…

This study tests whether measuring gene transcripts in the blood can help diagnose neuroendocrine tumors and assess how completely surgery removed them. Researchers will track blood levels after surgery and compare them with imaging to see if a rise in these markers signals tumor…

This trial is evaluating whether a specialized ultrasound technique, called shear wave elastography, can accurately identify pancreatic cancer. The study will include 130 adults with a solid pancreatic mass of unknown cause. By measuring tissue stiffness, the technique may help d…

This trial is testing whether a special PET/CT scan, typically used for prostate cancer, can better detect hepatocellular carcinoma (the most common type of liver cancer) compared to standard CT or MRI scans. The study will enroll about 30 adults with liver lesions suspicious for…

This study investigates whether hearing problems are an under-recognized complication of diabetes. Researchers will screen 172 adults with type 1 or type 2 diabetes using hearing tests and a questionnaire. If a hearing issue is found, a more detailed assessment will be done to de…

This study tested whether treating private well water with ultraviolet (UV) light can prevent stomach and respiratory infections in children under 5. Researchers gave 28 Pennsylvania households either a real UV device or a fake one and tracked illness symptoms via weekly texts. T…

Women with class III obesity who gain too much weight during pregnancy face higher risks of diabetes, high blood pressure, cesarean delivery, and larger babies. Standard prenatal care often does not include nutrition counseling based on weight. This trial tests whether adding gro…

Researchers are testing whether tegoprazan 25 mg works as well as lansoprazole 15 mg at preventing stomach and duodenal ulcers in people who take NSAID pain relievers for at least six months. The trial enrolls adults aged 60 or older, or younger adults with a history of such ulce…

Researchers at Stanford University are testing whether the Diabetes Body Project, a six-session group program, can reduce eating disorder symptoms and improve blood sugar control in young women with type 1 diabetes. The study enrolls 55 female-identifying participants aged 15 to …

Researchers are testing whether a supplement made from nine fungal extracts, called MICODIGEST 2.0, can reduce complications after surgery for colorectal cancer. The trial enrolls 48 adults scheduled for curative-intent surgery. Half receive the supplement and half receive a plac…

This study tested whether adding a special 'pre-session'—which includes education about diabetes risks, motivational interviewing, and help solving barriers—could encourage more people to attend a national diabetes prevention program. The trial involved 483 adults at risk for dia…

This trial tests whether using a technique called hybrid argon plasma coagulation (h-APC) on the edges of the removal site can prevent colon polyps from growing back after endoscopic mucosal resection (EMR). EMR is a standard procedure for removing large polyps, but when polyps a…

This study tested a program to increase colorectal cancer screening among adults aged 50-74 in 12 counties in Appalachian Kentucky and Ohio. The program included efforts targeting clinics, doctors, patients, and the community. Researchers measured screening rates using clinic rec…

This trial tests whether a structured education program can improve colorectal cancer knowledge, health beliefs, and screening uptake in adults aged 50-70. Participants are randomly assigned to receive the program—combining face-to-face teaching, a video, and a brochure—or to a c…

Researchers are testing whether a drug called eflornithine can reduce DNA damage in stomach cells that have precancerous changes. The trial enrolls adults aged 30 to 60 with atrophic gastritis or intestinal metaplasia, conditions that raise stomach cancer risk. Participants take …

This trial tests whether sending a colorectal cancer screening kit directly to people's homes, along with the invitation letter, increases the number of people who get screened. It compares this approach to the standard practice of asking people to visit their doctor to receive t…

This trial asks whether giving dialysis patients four doses of a double-strength hepatitis B vaccine offers better protection than the standard three doses. People with kidney failure on dialysis often respond weakly to vaccines, leaving many unprotected. The study will compare a…

This pilot trial tests whether a multi-part program given to emergency department patients with metabolic syndrome can encourage more walking and healthier habits. Participants receive a Fitbit, watch a short educational video, get a written exercise prescription, receive text re…

This trial asks whether endoscopic glue injection or the beta-blocker propranolol is better at preventing the first bleeding episode from gastric varices—enlarged veins in the stomach that can rupture in people with liver cirrhosis. Adults aged 18 to 80 with cirrhosis and gastric…

This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and ca…

People with type 2 diabetes often need daily insulin injections and blood sugar checks, which can cause pain and fear. Researchers are testing whether viewing a nature image on a screen for a few minutes before these procedures reduces pain and fear. The trial enrolls 64 adults w…

This study is testing the drug eluxadoline (Viberzi) in children aged 6 to 17 who have irritable bowel syndrome with diarrhea (IBS-D). The goal is to see if it improves stool consistency and is safe for kids. About 95 children will take either the drug or a placebo for 4 weeks, a…

Researchers compare three dietary approaches for adults with irritable bowel syndrome (IBS): a low-FODMAP diet, adapted NICE dietary advice, and adapted NICE advice combined with 16:8 intermittent fasting. About 90 adults aged 18 to 65 with IBS follow one diet for two weeks. The …

Researchers at Hanoi Medical University are testing whether personalized meals and diet coaching help stomach and colon cancer patients who are starting chemotherapy. About 120 adults receive tailored menus in the hospital, then learn to prepare high-energy, high-protein diets at…

This study tests whether remimazolam, a newer anesthetic, can reduce the risk of postoperative delirium (sudden confusion) in elderly patients undergoing laparoscopic stomach cancer surgery. Researchers will compare remimazolam to standard anesthesia in 170 patients aged 65 and o…

Researchers at National Taiwan University Hospital are testing whether a single-port robotic surgery system can safely remove the gallbladder and clear stones from the bile duct in one operation. The study enrolls 24 adults with symptomatic gallstones, with or without bile duct s…

This study looked at two oral chemotherapy drugs, Xeloda and UFT with folinic acid, in 89 people with advanced or metastatic colorectal cancer. The main goal was to see which treatment patients preferred after trying both. The study also checked how safe each drug was. Results he…

This study tests whether a program combining resistance training and a Mediterranean diet is practical and helpful for people with head and neck cancer undergoing radiation. Forty participants will receive supervised exercise sessions and pre-made meals, plus dietary coaching. Th…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

This study compares two versions of a procedure called POEM for people with achalasia, a condition where the esophagus doesn't relax properly, making swallowing difficult. About 52 adults with type I or II achalasia will be randomly assigned to receive either the standard circula…

Researchers are studying whether a stoma self-care app, accessed through the LINE messaging platform, can help people with an enterostomy improve their self-care and quality of life. The study enrolls 50 adults who have a colostomy and can use a smartphone. It combines two models…

Researchers at Hacettepe University are testing whether adding aerobic exercise to abdominal massage helps adults with functional constipation. The trial enrolls 64 people aged 18 to 65 who have chronic constipation and no recent treatment changes. Participants are randomly assig…

This study tested a video-based telemedicine program called REDCHiP for parents of young children (ages 2-6) with type 1 diabetes. The program uses education, behavior training, and therapy to reduce parents' fear of hypoglycemia (low blood sugar). 396 families participated, comp…

This study tests whether a 6-week program of non-weight bearing exercise can help diabetic foot ulcers heal faster than standard wound care alone. Forty adults with type 2 diabetes and a foot ulcer will be randomly assigned to exercise plus standard care or standard care only. Re…

Researchers at Jagiellonian University are studying whether a supplement made from freeze-dried black raspberries and strawberries affects inflammation in people over 65 receiving treatment for colorectal cancer. About 70 participants take the anthocyanin-rich supplement for 21 d…

Researchers compare two surgical techniques for rebuilding the tongue after cancer removal: the submental island pedicled flap, taken from under the chin, and the radial forearm free flap, taken from the arm. Twenty-eight adults with tongue cancer that requires partial or total r…

This study compares two common anesthetics—propofol and sevoflurane—to see which one causes less confusion (delirium) after surgery in older diabetic patients. Researchers will enroll 450 people aged 60 and older undergoing non-cardiac surgery. The goal is to find the best anesth…

Many people with gastroesophageal reflux disease still have heartburn even when they take proton pump inhibitors. The SIRUP trial compares the Stretta procedure, which uses radiofrequency energy on the esophagus, with a sham procedure in adults who have at least three heartburn e…

Researchers are testing whether a two-week course of functional magnetic stimulation applied to the sole of the foot can improve feeling, foot strength, balance, and walking in adults with type 2 diabetes and diabetic peripheral neuropathy. Participants are randomly assigned to r…

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

This study tested whether adding reflective materials like aluminum foil or white cloth around babies during light therapy for jaundice helps lower bilirubin faster. 81 newborns with mild jaundice were randomly assigned to standard therapy, therapy with white cloth reflectors, or…

Researchers are testing whether taking citrulline by mouth helps people with intestinal failure build protein more effectively. The study includes adults with short bowel syndrome who are fed orally and not on parenteral nutrition. Participants receive either citrulline or a plac…

Researchers compare two drugs that reduce stomach acid, rabeprazole and omeprazole, in obese adults with gastroesophageal reflux. Participants receive a single dose of each drug, plus a placebo, and researchers measure stomach acid for 24 hours after each dose. The goal is to see…

This early-stage trial tests a noninvasive device that uses magnetic pulses to stimulate nerves in the upper back. The goal is to reduce severe nausea, vomiting, and stomach pain in people with diabetic gastroparesis (stomach paralysis). About 48 adults with moderate-to-severe sy…

Researchers are testing whether milk and dairy products made with A2 beta-casein protein can improve gut symptoms, quality of life, sleep, and nutritional blood markers in adolescents with celiac disease. The trial enrolls 50 teens aged 10 to 18 who were diagnosed with celiac dis…

This pilot study compares two types of surgical mesh, biological and synthetic, used during a combined operation for pelvic organ prolapse and rectal prolapse. Thirty participants with obstructed defecation syndrome and pelvic organ prolapse undergo laparoscopic mesh sacropexy pl…

Doctors often withhold food from patients being treated for diabetic ketoacidosis in the intensive care unit, but no evidence supports this practice. Researchers are testing whether starting an oral diet early in treatment helps resolve the condition faster and shortens ICU and h…

This study tests whether a daily dose of Skal Pro—a mix of a friendly bacteria (Lactobacillus plantarum 299v) and a prebiotic fiber—can reduce IBS symptoms like belly pain, bloating, and irregular bowel movements. Sixty adults with IBS will receive either the supplement or a dumm…

Researchers are testing whether cognitive behavioral therapy for insomnia (CBT-I) can improve blood sugar control in older Chinese adults with type 2 diabetes and insomnia. The trial compares CBT-I to usual care in 214 participants aged 60 and older. They will measure changes in …

Researchers are testing an experimental drug called soticlestat in people with two rare genetic conditions: Dup15q syndrome and CDKL5 deficiency disorder. Both conditions cause frequent motor seizures that are hard to control. The trial enrolls about 20 participants who take one …

People with type 2 diabetes often face higher rates of anxiety and depression than the general public. Researchers at Dasman Diabetes Institute are testing whether six weeks of guided breath awareness, practiced inside a pyramid-shaped structure, can reduce those symptoms. The pi…

This study tests whether a new medicine called CagriSema can reduce nerve pain in people with type 2 diabetes. About 142 adults with painful diabetic neuropathy will receive either CagriSema or a placebo for around 10 months. The main goal is to see if the drug lowers weekly pain…

People with liver cirrhosis often have abnormal cholesterol and triglyceride levels. Researchers at Northern Jiangsu People's Hospital are following 150 cirrhosis patients who undergo laparoscopic splenectomy and azygoportal disconnection, a common operation for bleeding caused b…

This study tested whether electrostimulation and compression can reduce nerve pain and improve quality of life in people with gastrointestinal cancer who developed peripheral neuropathy from oxaliplatin chemotherapy. 140 patients were split into four groups: control, electrostimu…

This study compared two methods of pain control after open stomach surgery: a nerve block (rectus sheath block) using bupivacaine versus standard epidural pain relief. Sixty adults scheduled for elective open gastrectomy were randomly assigned to one of the two groups. The resear…

Irritable bowel syndrome causes abdominal pain and changes in bowel habits, and diet often makes symptoms worse. Many patients struggle to get dietary advice because of long waits and few resources. This trial tests whether virtual dietitian consults, one-on-one and in online gro…

This small study in Uganda looks at how meals made with local fruits and vegetables affect blood sugar and fat levels in people with type 2 diabetes. Eight participants will eat five different test meals over five weeks, with blood samples taken over three hours after each meal. …

This early-phase study tests whether anakinra, a drug that blocks inflammation, can make the heart more sensitive to inotropes (medicines that strengthen heart contractions) in people with end-stage heart failure. If successful, patients might need lower, safer doses of inotropes…

This trial tests whether applying a phenytoin-loaded hydrogel to surgical wounds can improve healing after oral cancer surgery. Adults with locally advanced oral squamous cell carcinoma who are having surgery to remove the tumor will receive either standard wound care or standard…

This study tests whether morning light therapy can improve sleep timing and reduce symptoms in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Sixty-eight adults with active IBD symptoms will either use a light therapy device at hom…

This study tested whether a device that gently stimulates the vagus nerve through the ear could reduce delayed stomach emptying after a major pancreatic surgery (pancreaticoduodenectomy). 84 patients were randomly assigned to receive the stimulation during surgery or not. The goa…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This study asks whether using a continuous glucose monitor (CGM) — a small sensor worn under the skin that tracks blood sugar levels in real time — can improve quality of life for adults with type 2 diabetes. Participants will use the device for 12 months and complete questionnai…

This trial tests whether using a virtual reality headset during a rectosigmoidoscopy (a type of colonoscopy) can reduce pain and anxiety in people with ulcerative colitis. Participants will be randomly assigned to receive standard care or to wear a VR headset that provides medica…

This trial tests whether two special diets can ease the symptoms of irritable bowel syndrome (IBS), a condition causing abdominal pain and altered bowel habits. Adults aged 19-64 with IBS will follow either a low-FODMAP diet or a combined gluten-free and lactose-free diet for six…

This pilot study explores whether cancer patients are willing to complete a quick self-screening for insomnia during clinic visits, and whether a video-based cognitive behavioral therapy (CBT-I) could help them sleep better. The study involves adults with breast, colorectal, lung…

This trial tests a nurse-assisted eHealth program for patients with heart failure or colorectal cancer. After leaving the hospital, participants use a tablet with the MyDignio app to track vital signs and symptoms, and communicate with a nurse navigator. The goal is to see if thi…

This study tests whether a walking program that uses FitBit tracking and personalized coaching can help people who recently had a leg amputation due to diabetes or peripheral artery disease become more physically active. Participants will use a FitBit to monitor their steps and r…

This study follows 140 people with obstructive defecation syndrome (ODS) — a condition that causes straining and difficulty passing stool — who are scheduled for surgery. Researchers will measure depression and anxiety using standard questionnaires before and after the procedure,…

This study investigates how easy or hard it is for adults with inflammatory bowel disease (IBD) to follow three different eating plans: intermittent fasting, the Mediterranean diet, and the low FODMAP diet. Researchers will interview participants to understand what helps or hinde…

This phase 2a trial tests whether an experimental oral drug called PORT-77 can lower levels of protoporphyrin IX (PPIX) in the blood of adults with erythropoietic protoporphyria (EPP). People with EPP experience severe pain and skin reactions after even brief sun exposure. The st…

This study looks at how the drug Hydronidone is absorbed, broken down, and removed from the body. Eight healthy Chinese men will take a single dose with a radioactive tracer so researchers can measure the drug in blood, urine, and stool. The goal is to understand the drug's journ…

This study investigates whether the unique bacteria found inside digestive system tumors can help predict how well a patient will respond to neoadjuvant therapy (chemotherapy before surgery). Researchers will analyze tumor samples from 90 adults with pancreatic, gastric, colorect…

This is the first time BAR502, an experimental drug for NASH (a serious liver condition), is being tested in humans. The study involves 52 healthy adults to check the drug's safety, tolerability, and how the body processes it. Participants receive either a single dose or multiple…

Researchers compare two operations for pancreatic tumors: partial removal of the pancreas and duodenum versus total removal of the pancreas. They analyze anonymized hospital records from 2013 to 2022 for about 3,600 adults in Switzerland. The study asks whether total removal is l…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

Hospitals face rising numbers of patients with chronic and complex conditions, and care teams are stretched thin. Researchers at a Belgian university hospital are studying what happens when nurse practitioners join four departments, including digestive surgery, liver cirrhosis ca…

Researchers are analyzing national administrative records to see how often workers file recognized hernia claims and how those claims are distributed by job type, hernia type, and region. The study uses existing data from about 4,500 recognized occupational hernia claims, so no o…

This early-stage study tests a single dose of the experimental drug efimosfermin alfa in 30 healthy adults of Chinese, Japanese, and White/European ancestry. The goal is to check safety, how the body processes the drug, and immune reactions. Participants will not receive any trea…

This study explores whether a special PET/MRI scan can predict how well esophageal cancer responds to chemotherapy and radiation given before surgery. Researchers will scan 121 patients during treatment and compare the images with the actual tumor response seen after surgery. The…

Researchers at Ghent University Hospital are studying whether MRI scans combined with computer models can measure the pressure inside tumors. High pressure in tumor tissue can block cancer drugs from reaching their target. The study enrolls 22 patients with pancreatic cancer or w…

This early-stage study is testing how the drug BMS-986435 behaves in the body and whether it is safe for people with mild to moderate liver problems compared to those with healthy livers. 24 adults will receive a single dose, and researchers will measure drug levels and monitor f…

This early-stage study tests a higher dose of Hydronidone capsules in 138 healthy Chinese adults to see how the drug moves through the body and if it is safe. Participants will receive single or multiple doses, and some will take the drug with food to see if meals affect absorpti…

This observational study investigates the role of hormonal and metabolic disorders in the development of gestational diabetes mellitus (GDM). Researchers are analyzing data from over 600 pregnant women to identify risk factors and markers that could predict adverse outcomes for b…

This study looked at whether being more physically active, measured by daily steps, helps rectal cancer patients respond better to chemotherapy and radiation before surgery. About 120 participants wore smartwatches to track their steps, heart rate, and sleep. The goal was to see …

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

Researchers are looking at whether the FIB-4 index, a blood-based score that estimates liver fibrosis risk, tracks with the severity of obstructive sleep apnea (OSA) and low oxygen levels during sleep. They will review records from 373 adults who had full-night sleep studies, gro…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…

Researchers are studying how two types of ulcerative colitis treatment, tofacitinib and anti-TNF drugs, affect platelet function and the body's clotting system. The trial enrolls adults with ulcerative colitis and compares blood and tissue samples before and after they start trea…

Researchers are studying whether delays in follow-up colonoscopies after certain polyp findings raise the risk of advanced growths or colorectal cancer. The study looks at medical records of adults aged 45 to 80 who had serrated lesions or high-grade dysplasia found during a colo…

Researchers want to understand what patients with early oesophageal cancer value most when deciding whether to have major surgery. The study uses interviews and a choice experiment with about 118 people under care for Barrett's, dysplasia, or oesophageal cancer. Participants answ…

Researchers are studying whether protein patterns in the blood can predict which people with esophageal cancer will respond completely to combined chemotherapy and radiation. The trial enrolls about 50 adults with invasive esophageal cancer who receive standard radiochemotherapy.…

This study looks at whether a continuous glucose monitor (CGM) can provide better insight into blood sugar patterns in pregnant women at risk for gestational diabetes than the usual oral glucose tolerance test (OGTT). Researchers will give 400 high-risk pregnant women a CGM senso…

Researchers are studying blood and tumor tissue from people with squamous cell cancer of the larynx, pharynx, or oral cavity who have no history of smoking, heavy drinking, or workplace exposure to substances like asbestos or wood dust. The goal is to learn how DNA changes and bi…

Researchers at Renmin Hospital of Wuhan University are studying whether brown fat activity is linked to nonalcoholic fatty liver disease. They analyze stored PET/CT scans and blood samples from 96 people who had clinically indicated scans. The goal is to find blood proteins that …

Researchers are surveying people in Thailand who have chronic hepatitis B to find out how many also carry hepatitis D, a virus that can make liver disease worse. The study focuses on groups at higher risk, including people who inject drugs, men who have sex with men, prisoners, a…

Researchers at Anhui Provincial Hospital are checking whether an existing risk model can predict five-year death risk in adults with fatty liver disease. The study uses health examination records from nearly 270,000 people seen between 2018 and 2024, including liver ultrasound, e…

This study looks at how the menstrual cycle changes blood sugar and energy use in women with type 1 diabetes. About 40 women will use a closed-loop insulin pump and continuous glucose monitor to track these changes. The goal is to understand how hormone shifts affect insulin need…

This study looked at how bacteria from the gut might travel to the liver and make liver disease worse in people with hepatitis C. Thirty adults with stable liver disease took part. Researchers used blood tests, MRI scans, and liver tissue samples to measure bacterial movement and…

This completed study looked at how to best find and manage tumors in people with Zollinger-Ellison syndrome, a rare condition that causes too much stomach acid. Researchers used imaging tests and tissue samples to locate tumors and check for a related genetic condition called MEN…

Researchers at Centre Oscar Lambret are studying how immune cells get inside breast and colon tumors. They will analyze stored tumor samples from about 70 patients treated between 2005 and 2007, looking at genes and proteins on blood vessel cells that may control this process. Th…

This study checked how many organ transplant recipients in the U.S. have antibodies to the hepatitis E virus, which can become chronic in people with weakened immune systems. Researchers enrolled 447 adults who had a liver, kidney, or small bowel transplant or were on a waiting l…

Researchers are testing two ways to train VA primary care clinicians to hold goals of care conversations with veterans who have serious illnesses such as cancer, heart failure, or dementia. One approach gives clinicians written materials and online training. The other adds team f…

This completed study looked at genetic factors that might increase the risk of esophageal and stomach cancers. Researchers collected DNA samples from over 7,700 people, including patients with cancer and healthy individuals from high- and low-risk areas in China. The goal was to …

This study follows up on over 32,900 people from Linxian, China, who took part in a nutritional trial between 1985 and 1991. Researchers are tracking cancer cases and deaths to see if earlier vitamin and mineral supplements had lasting effects. They are also collecting blood samp…

This study in Bauchi, Nigeria, is testing whether giving free Oral Rehydration Salts (ORS) and zinc directly to homes can increase how often these treatments are used for children under 5 with diarrhea. Over 100,000 children are taking part, with some areas receiving the medicine…

This completed study enrolled over 50,000 adults aged 40-75 in Iran's Golestan Province to understand why esophageal cancer is so common there. Participants filled out lifestyle and diet questionnaires and provided blood, urine, hair, and nail samples. Researchers are analyzing f…

This study looked at whether a 4-week moderate resistance training program could improve diaphragm thickness, liver fat, and quality of life in healthy men aged 60-75. Thirty participants were split into an exercise group or a control group that kept their normal routine. Researc…

This study collected information from 733 people with a personal or family history of hereditary stomach cancer. The goal was to better understand how these cancers develop and what genes are involved. Participants provided medical history, blood samples, and genetic testing. The…

Researchers at a large hospital in Seoul reviewed records from nearly 33,000 adults who had curative-intent surgery for one of seven cancers in the abdomen or pelvis: pancreatic, gastric, rectal, cervical, endometrial, kidney, or prostate. They grouped patients by whether they re…

This study looked at how people with and without non-alcoholic fatty liver disease (NAFLD) process food. Researchers monitored 53 adults over two days, measuring metabolism, blood, and urine after meals. The goal was to find differences that might explain why fat builds up in the…

This study looked at 805 blood donors who tested positive for hepatitis C virus (HCV) to learn how the virus spreads and affects health over time. Researchers collected blood samples and health information to track infection and liver disease. The goal was to better understand HC…

Researchers are studying whether the lining of the small intestine shows signs of inflammation in people with Familial Mediterranean Fever (FMF), a genetic condition that causes recurring fevers and pain. The study compares intestinal biopsy samples from about 30 adults with FMF …

Researchers in Taiwan are building a nationwide registry of people diagnosed with gastrointestinal stromal tumors, a rare cancer of the digestive tract. The study collects details on how the tumors are found, their stage, the treatments patients receive, and how they fare over ti…

This study looked at how different types of aerobic exercise (moderate continuous training vs. high-intensity interval training) and diet counseling affect cell health in people with type 2 diabetes. Researchers measured changes in mitochondria (the cell's power plants) and oxida…

Researchers are studying how a single oral dose of soticlestat behaves in adults with mild or moderate liver impairment compared with healthy adults. The trial measures drug levels in the blood and tracks side effects over an 8-day clinic stay. The goal is to understand whether l…

Researchers at KK Women's and Children's Hospital are studying whether the timing of meals and snacks during pregnancy relates to blood sugar levels. About 300 pregnant women in Singapore, between 18 and 21 weeks gestation, will keep food diaries and use a food record app. The te…

Researchers want to learn which molecules on cancer cells the immune system attacks when checkpoint inhibitor drugs work well. They collect tumor and blood samples from adults with solid tumors who respond to these drugs, either during treatment or after surgery. The team then se…

This study compares two common anesthesia gases, sevoflurane and desflurane, to see which one puts less strain on the lungs during gallbladder removal surgery. Researchers will measure lung mechanics at three points during the operation in 138 adults. The goal is to find out if o…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

This completed study looked at 1759 adults aged 18-55 to uncover why some people develop type 2 diabetes. Researchers measured how the body handles sugar, uses energy, and stores fat, and also collected genetic samples. The goal was to find genetic and lifestyle factors that lead…

This study reviews medical records of 350 adults who had surgery for esophageal cancer in France between 2017 and 2024. Researchers want to understand how often infections happen after surgery, what causes them, and how they affect recovery. The goal is to find ways to prevent th…

This study is testing whether a green dye called ICG can help surgeons see tumors more clearly during surgery in children and teens with solid tumors. The dye is injected before surgery and makes tumor tissue glow under a special camera. The goal is to see if this technique helps…

Researchers are examining the medical records of 12,000 people with type 2 diabetes who visited a large diabetes care center in Southern India during 2022 and 2023. The study aims to estimate how many of these patients have kidney insufficiency, a complication that past estimates…

This study follows people treated for anal cancer with radiotherapy to see how their sexual quality of life changes over time. Participants complete questionnaires during treatment, three months later, and two years after diagnosis. The goal is to understand the long-term impact …

Researchers at the University at Buffalo are studying whether insulin can reduce inflammation by suppressing toll-like receptors, which are part of the body's immune alarm system. The trial compares insulin infusion with dextrose and saline infusions in three groups: lean healthy…

This study uses computer simulations to compare two treatment strategies for people with chronic kidney disease and type 2 diabetes. Researchers will model whether adding empagliflozin to finerenone reduces heart failure, hospitalizations, and cardiovascular death more than finer…

This study tested a new, faster care plan for people with chronic constipation at a University of Michigan gastroenterology clinic. Researchers wanted to see how often doctors ordered special tests and pelvic floor therapy, and how satisfied patients were with their care. The stu…

This observational study follows people with hepatitis B-related acute-on-chronic liver failure who receive one of three antiviral drugs: entecavir, tenofovir alafenamide, or tenofovir amibufenamide. Researchers measure two newer virological markers, HBV RNA and HBcrAg, over time…

Researchers are studying whether certain molecules in the blood can predict how well patients with liver cirrhosis will do after leaving the hospital. The trial enrolls adults aged 18 to 80 who were admitted for a serious complication of cirrhosis, such as fluid buildup, confusio…

This study looks at the gut bacteria of premature babies to see if differences exist between those who develop necrotizing enterocolitis (NEC) — a severe bowel condition — and those who do not. Researchers collect weekly blood and daily stool samples from about 300 premature infa…

This study looks at 672 people with active ulcerative colitis to find the best treatment target. Participants are split into three groups: one aiming for symptom relief only, another for symptom plus endoscopic healing, and a third for symptom, endoscopic, and microscopic healing…

People with liver cirrhosis and portal hypertension often have kidney problems because of reduced blood flow and fluid buildup. Researchers at one hospital are reviewing medical records of patients who had laparoscopic splenectomy and azygoportal disconnection, a minimally invasi…

This completed study in Kazakhstan looked at 240 adults recently diagnosed with diabetes. Researchers measured blood sugar, insulin resistance, and immune markers to understand how different forms of diabetes develop. The goal is to help doctors diagnose and treat adult-onset dia…

This study is testing whether following a Mediterranean-style diet based on U.S. dietary guidelines improves heart health more when combined with weight loss. Researchers will provide all meals for 70 adults with obesity or excess body fat for eight weeks. Participants will be sp…

Researchers are studying how the body handles two experimental drugs, VIR-2218 and VIR-3434, in adults with cirrhosis and liver impairment. Participants receive a single injection of one drug or both together. The trial measures drug levels in the blood and checks for side effect…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study looked at 30 adults with Alpha-Gal syndrome, a condition where eating red meat causes allergic reactions. Participants ate cooked ground pork with or without a sugar called alpha-gal, then researchers checked for allergic reactions, gut symptoms, and changes in immune …

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

This study follows 110 adults having elective laparoscopic gallbladder surgery to see if eating a Mediterranean diet beforehand is linked to faster bowel recovery after the operation. Researchers measure diet adherence with a questionnaire and then track when bowel sounds, gas, a…

Researchers are studying 116 people with chronic watery diarrhea to see how many actually have microscopic colitis, a gut condition that standard tests often miss. Participants will give blood and stool samples and undergo a full colonoscopy with tissue biopsies from different pa…

Researchers in Belgium are studying adults with type 2 diabetes to understand how often they develop non-alcoholic fatty liver disease (NAFLD) and what that condition looks like. Participants will undergo a liver scan, provide blood samples, and answer questionnaires about their …

Researchers are reviewing records from 60 people with liver cirrhosis and portal hypertension who had colon polyps removed during a colonoscopy. The goal is to see whether bleeding right after the procedure or in the following days happens more often in this group. The study also…

Researchers are testing whether two types of bariatric surgery, Roux-en-Y gastric bypass and sleeve gastrectomy, reduce how much dietary protein older adults digest. The study compares adults aged 65 and older who had surgery 1 to 10 years ago with younger adults and with people …

This study compares two diets in people with overweight and early signs of blood sugar problems: a low-carbohydrate diet and a Mediterranean diet, both designed to produce similar weight loss. Each participant follows both diets for four weeks, in random order, with a break in be…

This study tests whether a software tool called Synapse Medicine can help hospital pharmacists who work with medical teams make better and faster medication recommendations. The tool analyzes each patient's health information to flag potential drug-related risks, such as harmful …

Researchers are using ultrasound to measure the thickness of ankle cartilage in people with type 2 diabetes who have nerve damage, and comparing it with healthy adults. Diabetic polyneuropathy may change how the lower limbs move, which could affect the ankle joint. The study incl…

This early-stage study looks at how the experimental drug nemtabrutinib is processed in people with moderate liver impairment compared to healthy volunteers. About 32 adults will receive a single oral dose, and researchers will measure drug levels in the blood over time. The goal…

Researchers at Indonesia University are studying how diet, body measurements, genetic profiles, and blood biomarkers relate to glucose levels in healthy adults. The trial includes 181 participants split into three groups: one follows a balanced diet, one follows a low-carbohydrat…

This study looks back at the medical records of 550 children who had surgery to remove a common bile duct cyst, a condition that can block bile flow and damage the liver. Researchers want to identify which factors, such as age or lab results, are linked to faster recovery of bowe…

This early-stage study tests the safety and tolerability of a new drug called QL2401 in 70 healthy Chinese adults aged 18 to 45. Participants receive either the drug or a placebo to see how the body handles it. The goal is to gather initial safety data before testing in people wi…

This study surveys over 3,700 medical students and interns across the Middle East to find out how many have gastroesophageal reflux disease (GERD). It also looks at how eating habits, stress, anxiety, and depression relate to GERD and how the condition affects their quality of li…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study is testing whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are acceptable and easy for adults with chronic diseases like IBD, hypertension, anemia, or multiple sclerosis to take. Researchers will also check if the supplements improve how w…

This completed study looked at risk factors for diabetes and heart disease in 146 healthy African, African-American, and white women who were federal employees or contractors. Researchers compared things like triglyceride levels and insulin resistance to see if the best screening…

This study looks at whether starting to eat within 24 hours after a colon polyp removal procedure (called ESD) is safe and better than waiting longer. About 204 patients will be randomly assigned to either early feeding (water after 2 hours, then liquid diet) or delayed feeding (…

This study compares bowel function and quality of life in adults who had a sigmoidectomy, a surgery to remove the sigmoid colon, for either diverticulitis or sigmoid cancer. Researchers will measure incontinence using a standard score and track stool form with the Bristol stool c…

This study looks at how body weight influences physical activity, balance, and quality of life in 50 adults with type 2 diabetes. Researchers will measure body composition, muscle strength, walking ability, and balance using simple tests and questionnaires. The goal is to better …

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This study aims to identify the unique molecular signature of immune cells called T cells that mistakenly attack the liver in autoimmune liver diseases like autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. Researchers will analyze blood sampl…

This study looked at liver fibrosis (scarring) in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Participants underwent tests like liver biopsy, ultrasound, and CT scans to measure liver damage. The goal was to understand how common and severe liver …

This study aims to identify which of four French-validated questionnaires is most suitable for assessing sexual function in women who have had surgery for rectal or recto-sigmoid cancer. Researchers will ask 50 women to complete all four questionnaires and rank their preferences.…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study tests whether a non-invasive device called Gastric Alimetry can detect changes in stomach muscle activity caused by semaglutide (Ozempic). Researchers will measure stomach electrical signals and symptoms in people with and without diabetes before and after taking the w…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study tests whether a novel MRI technique called Fast Field Cycling imaging and the bacteria in the mouth and bowel can predict how well rectal cancer responds to chemoradiotherapy given before surgery. Researchers will scan 15 patients three times and collect saliva and sto…

This study builds a global registry of adults with anal squamous cell carcinoma, both with and without HIV infection. Researchers will collect real-world data on treatments, lab results, and outcomes to compare how the disease progresses in each group. The goal is to identify fac…

Researchers are examining whether liver fibrosis, measured by non-invasive scores, correlates with estimated 10-year cardiovascular risk in adults with metabolic dysfunction-associated steatotic liver disease (MASLD). The study uses data from 271 adults aged 30 to 79 and focuses …

This trial tests whether an early PET scan can help doctors choose the right treatment for people with locally advanced oesophago-gastric cancer. Patients receive one round of standard chemotherapy, then a second PET scan. If the tumor shows a strong response, they continue chemo…

This observational study looks at records from Israel's National Insurance Institute to understand how often diabetes is linked to permanent disability. It will compare disability rates and severity across different regions and over time, from 2020 to 2025. No treatments or tests…

This pilot study tests whether eating a low-carbohydrate, high-unsaturated-fat diet for three days can alter the liver's fat composition and the activity of genes linked to fat metabolism, inflammation, and scarring in people with pre-diabetes. Participants will follow either thi…

This trial tests whether a 15-minute educational video and a list of suggested questions can improve understanding of immunotherapy among patients with advanced cancer and their caregivers. Participants are randomly assigned to receive the educational materials or usual care, and…

This study follows adolescents with youth-onset type 2 diabetes, along with obese and lean peers, into young adulthood to see how their kidneys change over time. Using advanced imaging and kidney function tests, researchers aim to understand early signs of diabetic kidney disease…

This study aims to develop a new laboratory technique to detect specific immune cells (called CD8 T cells) that target the hepatitis C virus (HCV). Researchers will use blood samples from people infected with HCV genotypes 1 or 4 to test and refine this technique. The goal is to …

This study is looking at whether peripheral artery disease (PAD) is linked to lower levels of regenerative cells in the blood. Researchers will compare blood samples from adults with PAD to those without the condition, measuring the number of certain progenitor cells and markers …

This trial is testing whether contrast-enhanced ultrasound (CEUS) can reliably measure tumor blood flow in people with metastatic cancers like GIST, breast, kidney, colon, rectal, or melanoma. Participants will have two ultrasound scans before starting anti-angiogenic treatment, …

This study is investigating how often dangerous heart rhythm problems occur in people receiving hemodialysis for end-stage kidney disease. Researchers will implant a small device under the skin to continuously monitor heart rhythm for 18 months in 70 patients, half of whom have d…

This study looks at whether adrenaline, the body's stress hormone, triggers an immune reaction during low blood sugar (hypoglycemia) in people with and without type 1 diabetes. Researchers will lower participants' blood sugar and then give drugs that block adrenaline's effects to…

This study aims to find out which germs cause summer diarrhea in children who visit the emergency room. Researchers will collect stool samples from children aged 0 to 16 and test them for viruses, bacteria, and parasites. The goal is to better understand the causes of these infec…

This trial investigates whether gluten consumption affects digestive comfort, quality of life, and physical performance in non-celiac athletes who train intensively. Participants, who are healthy and free of digestive diseases, will be randomly assigned to a gluten-containing or …

This study looks at whether jaundice, a yellowing of the skin and eyes, makes people with cirrhosis more likely to develop infections while in the hospital. Researchers will follow 250 Egyptian patients with cirrhosis to see if those with jaundice get more hospital-acquired infec…

This study explores whether compounds in cannabis, like THC and CBD, can reduce inflammation and improve how the body responds to insulin. Researchers will measure blood markers of inflammation and insulin sensitivity in people across the weight spectrum, both after a single use …

This study looks at whether having certain E. coli bacteria in the colon after colorectal cancer surgery is linked to anxiety or depression. Researchers will compare psychiatric symptoms and diagnoses between patients who carry the bacteria and those who do not. The goal is to be…

This study looks at how a surgeon's growing experience with single-incision laparoscopic surgery—a minimally invasive technique using a single small cut—affects short- and long-term results for people with rectal or sigmoid colon cancer. By analyzing past cases from one surgical …