New pill aims to tame ulcerative colitis Flare-Ups
NCT ID NCT05507203
First seen Jun 25, 2026 · Last updated Sep 11, 2026 · Updated 4 times
Summary
This study tested a once-daily pill called ABX464 (obefazimod) in 639 people with moderate-to-severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could help bring about remission and improve bowel inflammation within 8 weeks. The trial is now complete, and results will show whether this new option is safe and effective.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ABX464 (obefazimod), a once-daily pill
- What this could lead to
- If successful, this could provide a new once-daily treatment option to help control ulcerative colitis and reduce symptoms.
- What could go wrong
- This is a completed Phase 3 trial, but results are not yet published. It may not show a clear benefit over placebo, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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639 people
The number who actually took part.
- Started
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Nov 2022
- Finished
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Jun 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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16 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Men or women at least 16 years old; Adolescent subjects will only be enrolled if approved by the country regulatory/health authority. If these approvals have not been granted, only subjects ≥ 18 years old will be enrolled. To be eligible, adolescent subjects must weight ≥ 40 kg and meet the definition of Tanner Stage 5 at the screening visit. * Subjects must understand, sign and date the written voluntary informed consent form at the visit prior to any protocol-specific procedures. For under-aged subjects, national requirements regarding consent should also be met. * Documented diagnosis of UC confirmed by endoscopy and histology. Should endoscopy/histology results not be available at screening, results from endoscopies or biopsies taken at screening may be used. * Active disease defined by modified Mayo score (MMS) ≥ 5 with rectal bleeding subscore (RBS) ≥ 1 and endoscopy subscore (MES) of 2 or 3 (confirmed by central reader). * Subjects with documented inadequate response (defined as lack of response or loss of response or intolerance) to at least one of the following treatments: corticosteroids, immunosuppressant, biologic or biosimilar therapies, S1P receptor modulators and/or JAK inhibitors and/or new drugs approved during the study (note: failure to only 5-ASA or sulfasalazine is not accepted). * Women of childbearing potential (WOCBP) subjects and male subjects with WOCBP partner must agree to comply with the contraception requirements described in the protocol. * Subjects able and willing to comply with study visits and procedures as per protocol. * Subjects should be affiliated to a health insurance policy whenever required by a participating country or state. Exclusion Criteria: * Subjects with UC limited to an isolated proctitis (≤ 15cm from anal verge) determined by endoscopy central reading. * Subjects with primary sclerosing cholangitis or autoimmune hepatitis. * Subjects who have failed on 5-ASA or sulfasalazine therapy only. * Subjects with CD or presence or history of fistula, indeterminate colitis, infectious/ischemic colitis or microscopic colitis (lymphocytic and collagenous colitis). * History or current evidence of toxic megacolon, fulminant colitis, bowel perforation. * History of colonic cancer or colonic low grade or high grade dysplasia adenomatous polyps, and/or at the screening endoscopy, evidence of colonic cancer or evidence of low grade or high grade dysplasia adenomatous polyps (fully removed or not). * Recent or planned bowel surgery or history of proctocolectomy or partial colectomy or current stoma. * Subjects on antidiarrheals including those working on motility (e.g., loperamide, diphenoxylate with atropine, etc.). * Subjects on probiotics (e.g., Culturelle® \[Lactobacillus GG, i-Health, Inc.\], Saccharomyces boulardii). * Subjects who do not meet the washout period requirements prior to the screening endoscopy * Subjects with the following hematological and biochemical laboratory parameters obtained during the screening period: * Hemoglobin ≤ 8.0 g dL-1 * Absolute neutrophil count \< 750 mm-3 * Platelets \< 100,000 mm-3 * Creatinine clearance \< 60 mL.min-1 (Cockroft-Gault formula) * Total serum bilirubin \> 1.5 x ULN * Alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \> 2 x ULN * Subjects with the following conditions (infection): * Subjects with chronic or recurrent grade 3 or grade 4 infection within the last 2 months prior to screening or a history of opportunistic infection while not on immunosuppressive therapy. * Herpes zoster reactivation within the last 2 months prior to screening. * Subjects with active infection at screening or any major episode of infection that required hospitalization or treatment with intravenous antibiotics within 1 month of screening or during screening. Fungal infection of nail beds is allowed. * Positive assay or stool culture for pathogens (ova and parasite examination, bacteria) or positive test for Clostridium difficile toxin at screening. If C. difficile is positive, subject may be treated and retested ≥ 2 weeks after completing treatment. * Subjects with HIV infection. * Subjects having acute or chronic hepatitis B infection at screening (positive for hepatitis B surface antigen \[HbsAg\], or negative for HbsAg and positive for anti-hepatitis B core antibody in conjunction with detectable HBV DNA, or detectable HBV DNA). * Subjects having acute or chronic hepatitis C infection at screening as defined by positive for hepatitis C antibody (subjects successfully treated and without recurrence ≥ 1 year with no detectable HCV RNA \[assessed centrally\] are eligible). * Active tuberculosis (TB) or untreated latent TB are ruled out. For subjects with positive or intermediate QuantiFERON test see study protocol. * Subjects with an uncontrolled ischemic heart disease and/or a history of congestive heart failure with New York Heart Association (NYHA) class 3 or 4 symptoms. * Subjects with a family or personal history of congenital or acquired long QT syndrome, or subjects with a marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTc interval \[Fridericia or Bazett correction\] \>450 milliseconds for male and \> 460 milliseconds for female). * Subjects with a history of torsade de pointe (TdP). * Acute or chronic of clinically relevant pulmonary, hepatic, pancreatic or renal functional abnormality, encephalopathy, neuropathy or unstable central nervous system pathology such as seizure disorder, or any other clinically significant medical problems as determined by physical examination and/or laboratory screening tests and/or medical history (note: treated autoimmune hypothyroidy and autoimmune diabetes are allowed). * Serious illness requiring hospitalization within 4 weeks prior to screening (except UC flare). * Subjects previously treated with ABX464. * Subjects with a known hypersensitivity to the active substance or to any of the excipients. * WOCBP subject who is pregnant or breast-feeding at screening, or intends to become pregnant during the study, or male subject with WOCBP partner who intends to be pregnant during the study. * Illicit drug or alcohol abuse or dependence. * Subjects who received live vaccine within 3 months prior to screening and/or who's planning to receive such a vaccine during the study duration. * Use of any investigational or non-registered product within 3 months or within 5 half-lives preceding baseline, whichever is longer, and during the study. * Subjects committed to an institution by virtue of an order issued either by the judicial or the administrative authorities. * Any condition, which in the opinion of the investigator, could compromise the subject's safety or adherence to the study protocol.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AKH - Medizinische Universität Wien
Vienna, 1090, Austria
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AMICARE spółka z ograniczoną odpowiedzialnością spółka komandytowa
Lodz, 90-644, Poland
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AZ Sint-Lucas
Bruges, 8310, Belgium
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Access Research Institute
Brooksville, Florida, 34613, United States
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Acibadem Kozyatagi Hospital
Istanbul, 34742, Turkey (Türkiye)
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Advanced Research Institute, Inc.
New Port Richey, Florida, 34653, United States
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Advanced Research Institute, Inc.
Orlando, Florida, 32825, United States
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Amrita Institute Of Medical Sciences and Research Centre
Kochi, Kerala, 682041, India
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Amsterdam UMC, Locatie AMC
Amsterdam, 1105 AZ, Netherlands
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Asan Medical Center
Seoul, 05505, South Korea
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Auzmer Research
Lakeland, Florida, 33813, United States
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Azienda Ospedaliera Giuseppe Brotzu
Cagliari, 09134, Italy
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Azienda Ospedaliera Ospedali Riuniti "Villa Sofia-Cervello"
Palermo, 90146, Italy
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Azienda Ospedaliero Universitaria Pisana (Presidio di Cisanello)
Pisa, Italy
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Baylor College Of Medicine
Houston, Texas, 77030, United States
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Baylor Scott and White
Dallas, Texas, 75246, United States
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Bekes Varmegyei Kozponti Korhaz
Békéscsaba, 5600, Hungary
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Bernhoven Uden
Uden, 5406 PT, Netherlands
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Binzhou Medical University Hospital
Binzhou, Shandong, 256603, China
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Biopharma Informatic, Inc. Research Center
Houston, Texas, 77043, United States
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Biopharma Informatic, LLC
Houston, Texas, 77084, United States
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Birmingham Digestive Health Research
Homewood, Alabama, 35209, United States
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Blue Ridge Medical Research
Lynchburg, Virginia, 24502, United States
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Box Hill Hospital
Box Hill, Victoria, 3128, Australia
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Bury Care Organisation
Bury, Greater Manchester, BL9 7TD, United Kingdom
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C. H. U. St-Pierre
Brussels, 1000, Belgium
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CCR Brno, s.r.o.
Brno, 60200, Czechia
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CCR Ostrava s.r.o.
Ostrava, 70200, Czechia
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CHU Besançon - Hôpital Jean Minjoz
Besançon, Doubs, 25000, France
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CHU Bordeaux - Hôpital Haut-Lévêque
Pessac, Gironde, 33604, France
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CHU Clermont Ferrand - Hopital d'Estaing
Clermont-Ferrand, Puy De Dome, 63000, France
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CHU Dijon - Hôpital Bocage Central
Dijon, Cote D'or, 21000, France
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CHU Nantes - Hôtel Dieu
Nantes, Loire Atlantique, 44093, France
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CHU Reims - Hôpital Robert Debré
Reims, Ardennes, 51100, France
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CHU Saint Etienne - Hôpital Nord
Saint-Étienne-de-Montluc, Pays de la Loire Region, 42055, France
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CHU UCL Namur
Yvoir, 5530, Belgium
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CNCE Khmelnytskyi Regional Hospital of Khmelnytskyi Regional Council
Khmelnytskyi, 29000, Ukraine
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CNCE Kyiv City Clinical Hospital #1 of Executive Body of Kyiv City Council
Kyiv, 02091, Ukraine
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CNCE of Lviv Regional Council Lviv Regional Clinical Hospital
Lviv, Ukraine
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CNE Cherkasy Regional Hospital of Cherkasy Regional Council
Cherkasy, 18009, Ukraine
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CNE M.I. Pyrohov Vinnytsia RCH of Vinnytsia Regional Council, RSC Gastro Center
Vinnytsia, 21018, Ukraine
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CNE Regional Clinical Hospital of Ivano-Frankivsk Regional Council
Ivano-Frankivsk, 76008, Ukraine
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CNE Uzhhorod city MCH of UCC Dept of Therapy
Uzhhorod, 88000, Ukraine
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California Medical Research Associates Inc.
Northridge, California, 91324, United States
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Canberra Hospital
Canberra, Australian Capital Territory, 2605, Australia
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Care Access Research LLC
Ogden, Utah, 84403, United States
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Care Access Research Lumberton
Lumberton, North Carolina, 28358, United States
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Central Texas Clinical Research, LLC
Austin, Texas, 78705, United States
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Centre Hospitalier de Pau - Hôpital François Mitterrand
Pau, Pyrénées Atlantique, 64000, France
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Centro Hospitalar de Entre o Douro e Vouga, E.P.E - Hospital de São Sebastião
Santa Maria da Feira, 4520-211, Portugal
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Centrum Medyczne Oporow
Wroclaw, 52-416, Poland
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Charité - Campus Benjamin Franklin
Berlin, 12203, Germany
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Charlotte Gastroenterology and Hepatology, P.L.L.C
Charlotte, North Carolina, 28207, United States
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Chhatrapati Shahuji Maharaj (CSM) Medical University
Lucknow, Uttar Pradesh, 226003, India
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Chopda Medicare & Research Centre
Nashik, Maharashtra, 422005, India
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Chung-Ang University Hospital
Seoul, 06973, South Korea
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Claraspital
Basel, 4058, Switzerland
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Clinexpert Kft.
Budapest, 1033, Hungary
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Clinic of the SRI of Invalid Rehab (EST Complex) of Pirogov Memorial NMU
Vinnytsia, 21029, Ukraine
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Clinica Gaias - Santiago
Santiago de Compostela, La Coruña, 15702, Spain
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Clinical Hospital Feofaniia of State Management of Affairs
Kyiv, 03143, Ukraine
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Clinical Research Of Brandon, LLC
Brandon, Florida, 33511, United States
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Clinnova Research Solutions
Orange, California, 92868, United States
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Concord Repatriation General Hospital
Concord, New South Wales, 2139, Australia
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Coral Sea Clinical Research Institute
North Mackay, Queensland, 4740, Australia
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DCC "Alexandrovska", EOOD
Sofia, 1431, Bulgaria
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DSI Research LLC
Springboro, Ohio, 45066, United States
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Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
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Dayanand Medical College and Hospital
Ludhiana, Punjab, 141001, India
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Debreceni Egyetem
Debrecen, Hungary
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Del Sol Research Management, LLC
Tucson, Arizona, 85715, United States
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Digestive Health Specialists of the Southeast
Dothan, Alabama, 36305, United States
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Digestive Research of Central Texas, LLC
Waco, Texas, 76301, United States
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Dnipro Division Medical Center Clinic of Family Medicine of LLC
Dnipro, 49000, Ukraine
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Dong-A University Hospital
Busan, 49201, South Korea
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ETG Zamosc
Zamość, 22-400, Poland
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ETZ Elisabeth
Tilburg, 5022 GC, Netherlands
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Eagle Clinical Research
Chicago, Illinois, 60621, United States
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Ege University Medical Faculty
Izmir, 35100, Turkey (Türkiye)
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Endoscopic Research, Inc.
Orlando, Florida, 32803, United States
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First Affiliated Hospital of Kunming Medical University
Kunming, Yun'nan, 650032, China
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Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Fondazione IRCCS Policlinico San Matteo
Pavia, 27100, Italy
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Fondazione Poliambulanza Istituto Ospedaliero
Brescia, 25124, Italy
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Fortis Memorial Research Institute
Gurgaon, Haryana, 122002, India
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GI Alliance
Sun City, Arizona, 85351, United States
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GI Alliance
Glenview, Illinois, 60026, United States
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GI Alliance
Gurnee, Illinois, 60031, United States
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GI Alliance - Garland
Garland, Texas, 75044, United States
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GI Alliance - Southlake
Austin, Texas, 76092, United States
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GI Alliance - Webster
Webster, Texas, 77598, United States
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GI Alliance -Gurnee
Mansfield, Texas, 76063, United States
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Gachon University Gil Medical Center
Incheon, 21565, South Korea
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Gastro Care Institute
Lancaster, California, 93534, United States
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Gastro Health & Nutrition
Katy, Texas, 78754, United States
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Gastroenterologie Berlin Karlshorst
Berlin, 10318, Germany
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Gastroenterology Associates of Pensacola, PA
Pensacola, Florida, 32503, United States
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Gastroenterology Center of the MidSouth PC
Germantown, Tennessee, 38138, United States
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Gastroenterology and Internal Medicine Research Institute
Edmonton, Alberta, T5R 1W2, Canada
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Gazi University Medical Faculty
Ankara, 06500, Turkey (Türkiye)
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General Hospital of Athens "Evangelismos"
Athens, 10676, Greece
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General Hospital of Eastern Theater Command
Nanjing, Jiangsu, 210002, China
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General Hospital of Thessaloniki "Hippokration"
Thessaloniki, 54642, Greece
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HUB Erasme
Brussels, 1070, Belgium
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Hammersmith Hospital
London, Greater London, W12 0HS, United Kingdom
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Hepato-Gastroenterologie HK s.r.o.
Hradec Králové, 50012, Czechia
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Hopital Saint Eloi
Montpellier, Herault, 34295, France
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Hospital Privado Centro Medico de Cordoba S.A
Córdoba, X5016KEH, Argentina
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Hospital Universitari i Politecnic La Fe
Valencia, 46026, Spain
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
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Hospital da Luz
Lisbon, 1500-650, Portugal
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Hospital da Senhora da Oliveira Guimarães
Guimarães, 4835-044, Portugal
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Hospital de Braga
Braga, 4710-243, Portugal
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Huddersfield Royal Infirmary
Huddersfield, West Yorkshire, HD3 3EA, United Kingdom
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Huzhou Central Hospital
Huzhou, Zhejiang, 313099, China
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Hôpital Bicêtre
Le Kremlin-Bicêtre, Val De Marne, 94275, France
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Hôpital Henri Mondor
Créteil, Val De Marne, 94010, France
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Hôpital Saint-Louis
Paris, 75475, France
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I.R.C.C.S Policlinico San Donato
San Donato Milanese, Milano, 20097, Italy
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IRCCS Ospedale Casa Sollievo della Sofferenza
San Giovanni Rotondo, Foggia, 71013, Italy
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Indiana University School of Medicine
Indianapolis, Indiana, 46202, United States
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Inje University Haeundae Paik Hospital
Busan, 48108, South Korea
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Inselspital - Universitaetsspital Bern
Bern, 3010, Switzerland
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Instituto de Investigaciones Clinicas Quilmes
Quilmes, Buenos Aires, B1878GEG, Argentina
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Intesto Gastroenterologische Praxis, Crohn-Colitis-Zentrum Bern
Bern, 3012, Switzerland
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Jiangxi Gannan Medical College Affiliated 1 st Hospital
Ganzhou, Jiangxi, 341000, China
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Jinan Central Hospital
Jinan, Shandong, 250013, China
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K.L.E. Society's Dr. Prabhakar Kore Hospital and Medical Research Centre
Belagāve, Karnataka, 590010, India
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KH der Barmherzigen Brüder St.Veit an der Glan
Sankt Veit an der Glan, 9300, Austria
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Kiepury Clinic MAŁGORZATA JARNOT SPECJALISTYCZNA PRAKTYKA GINEKOLOGICZNO-POŁOŻNICZA
Sosnowiec, 41-200, Poland
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King's College Hospital
London, Greater London, SE5 9NU, United Kingdom
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Kingsway Hospital
Nagpur, Maharashtra, 440001, India
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Kocaeli Universitesi Tip Fakultesi
Kocaeli, 41380, Turkey (Türkiye)
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Korea University Ansan Hospital
Ansan-si, Gyeonggi-do, 15355, South Korea
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Kyung Hee University Hospital
Seoul, 02447, South Korea
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Kyungpook National University Hospital
Daegu, 41944, South Korea
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LKH - Universitaetsklinikum Graz
Graz, 8036, Austria
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LKH - Universitätsklinikum der PMU Salzburg
Salzburg, 5020, Austria
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LLC Medical Center The Clinic of Hospodarskyy
Ternopil, 46002, Ukraine
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LMU - Campus Grosshadern
Munich, Bavaria, 81337, Germany
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Lakeview Clinical Research
Guntersville, Alabama, 35976, United States
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Liaocheng People's Hospital
Liaocheng, Shandong, 252000, China
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Limited Liability Company Medical Center Health Clinic, Medical Clinical Research Center
Vinnytsia, 21009, Ukraine
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Liuzhou People's Hospital
Liuzhou, Guangxi Zhuang, 545006, China
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Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
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Lubbock Digestive Disease Associates
Lubbock, Texas, 79410, United States
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Lucida Clinical Trials LLC
New Bedford, Massachusetts, 02740, United States
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M. S. Ramaiah Medical College and Hospital
Bangalore, Karnataka, 560054, India
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Mater Misericordiae Ltd
South Brisbane, Queensland, 4101, Australia
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McGill University Health Centre- Montreal General Hospital
Montreal, Quebec, H3G 1A4, Canada
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Medical Center of Limited Liability Company Medical Center Concilium Medical
Kyiv, 04050, Ukraine
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Medical Center of Limited Liability Company Saliutas
Lviv, 79005, Ukraine
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Medical Professional Clinical Research Center
Miami, Florida, 33165, United States
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Medical center Medconsult Pleven OOD
Pleven, 5800, Bulgaria
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Medizinische Hochschule Hannover
Hanover, Lower Saxony, 30625, Germany
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Medizinische Universität Innsbruck
Innsbruck, 6020, Austria
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Mersin University Medical Faculty
Mersin, 33343, Turkey (Türkiye)
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Midas Multispeciality Hospital Pvt Ltd
Nagpur, Maharashtra, 440010, India
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NSZOZ Termedica - Centrum Badan Klinicznych
Poznan, 60-681, Poland
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NZOZ Centrum Medyczne ProMiMed
Krakow, 31-637, Poland
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NZOZ VIVAMED Jadwiga Miecz
Warsaw, 03-580, Poland
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Nanfang Hospital of Southern Medical University
Guangzhou, Guangdong, 510515, China
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Nature Coast Clinical Research - Inverness
Inverness, Florida, 34452, United States
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Navneet Memorial Hospital 'Sushrusha'
Ahmedabad, Gujarat, 380009, India
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Nemocnice Slany
Slaný, 27401, Czechia
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Nil Ratan Sircar Medical College
Kolkata, West Bengal, 700014, India
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Novel Research LLC
Bellaire, Texas, 77401, United States
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One Health Research Clinic Atlanta, LLC
Norcross, Georgia, 30093, United States
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Orlando Health-Orlando Regional Medical Center
Orlando, Florida, 32806, United States
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Ospedale Sacro Cuore Don Calabria
Negrar, Italy
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Ospedale San Raffaele
Milan, 20132, Italy
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Pannonia Maganorvosi Centrum
Budapest, 1136, Hungary
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Peak Gastroenterology Associates
Colorado Springs, Colorado, 80907, United States
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Peking University First Hospital
Beijing, Beijing Municipality, 100034, China
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Peking University Third Hospital
Beijing, Beijing Municipality, 100191, China
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PlanetMed sp. z o.o.
Wroclaw, 52-210, Poland
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Praxis fuer Gasroenterologie Prof. Dr. med Robert Ehehalt
Heidelberg, Baden-Wurttemberg, 69121, Germany
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PreventaMed s.r.o.
Olomouc, 77200, Czechia
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Przychodnia Specjalistyczna Insula
Bełchatów, 97-400, Poland
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Qilu Hospital of Shandong University
Jinan, Shandong, 250012, China
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RCNE Chernivtsi Regional Clinical Hospital Gastroenterology Subdivision Bukovinian SMU
Chernivtsi, 58001, Ukraine
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Renji Hospital Shanghai Jiaotong University School of Medicine - West Branch
Shanghai, Shanghai Municipality, 200127, China
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Renmin Hospital, Wuhan University
Wuhan, Hubei, 430060, China
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Rochester Clinical Research
Rochester, New York, 14609, United States
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Royal London Hospital
London, Greater London, E1 1FR, United Kingdom
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Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
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Royal Perth Hospital
Perth, Western Australia, 6000, Australia
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Ruby Hall Clinic
Pune, Maharashtra, 411001, India
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Ruijin Hospital of Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, 200025, China
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S. R. Kalla Memorial Gastro & General Hospital
Jaipur, Rajasthan, 302001, India
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SOLUMED Centrum Medyczne
Poznan, 60-529, Poland
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STAT Research S.A.
Ciudad Autonoma Buenos Aires, C1013AAB, Argentina
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Sahyadri Specialty Hospital
Pune, Maharashtra, 411028, India
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Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lecznej
Łęczna, 21-010, Poland
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Samsung Medical Center
Seoul, 06351, South Korea
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Scott Shulman Medicine Professional Corporation
North Bay, Ontario, P1B 2H3, Canada
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Semmelweis Egyetem
Budapest, 1082, Hungary
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Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Shengjing Hospital of China Medical University
Shenyang, Liaoning, 110022, China
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Shree Giriraj Multispeciality Hospital
Rajkot, Gujarat, 360005, India
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Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310018, China
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St Mark's the National Bowel Hospital
London, Greater London, NW10 7NS, United Kingdom
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St Vincent's Hospital Melbourne
Fitzroy, Victoria, 3065, Australia
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Staedisches Klinikum Brandenburg
Brandenburg an der Havel, Brandenburg, 14770, Germany
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SurGal Clinic s.r.o.
Brno, 60200, Czechia
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Szpital Zakonu Bonifratow Sp. z o.o.
Katowice, 40-211, Poland
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Taian City Central Hospital
Tai’an, Shandong, 271000, China
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Texas Digestive Disease Consultants
Cedar Park, Texas, 78613, United States
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The 2nd Xiangya Hospital of Central South University
Changsha, Hu'nan, 410011, China
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The 900th Hospital of The Chinese People's Liberation Army Joint Logistics Support Force
Fuzhou, Fujian, 350025, China
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The Affiliated Hospital of Qingdao University
Qingdao, Shandong, 266003, China
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The Affiliated Hospital of Southwest Medical University
Luzhou, Sichuan, 646099, China
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The Alfred Hospital
Melbourne, Victoria, 3004, Australia
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The Catholic University of Korea, Daejeon St. Mary's Hospital
Daejeon, 34943, South Korea
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The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, 06591, South Korea
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The Catholic University of Korea, St. Vincent's Hospital
Suwon, Gyeonggi-do, 16247, South Korea
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The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, 230022, China
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The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, 350005, China
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The First Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, 471003, China
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The First Affiliated Hospital of Nanyang Medical College
Nanyang, Henan, 473000, China
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The First Affiliated Hospital of Sun Yat-sen University
Yuexiu, Guangdong, 510080, China
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The First Affiliated Hospital of University of South China
Hengyang, Hu'nan, 421001, China
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450000, China
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The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310003, China
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The First People's Hospital of Foshan
Foshan, Guangdong, 528000, China
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The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
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The Sixth Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, 510655, China
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The Ulster Hospital
Belfast, BT16 1RH, United Kingdom
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Theia Clinical Research Centers, LLC
Temple Terrace, Florida, 33617, United States
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Tianjin Union Medical Center
Tianjin, Tianjin Municipality, 300121, China
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Twoja Przychodnia Opolskie Centrum Medyczne
Opole, 45-819, Poland
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Twoja Przychodnia PCM
Poznan, 61-293, Poland
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Twoja Przychodnia-Szczecinskie Centrum Medyczne Sp. z o. o.
Szczecin, 71-434, Poland
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UMHAT 'Tsaritsa Yoanna - ISUL', EAD
Sofia, 1527, Bulgaria
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UMHAT Prof. Dr. Stoyan Kirkovich AD
Stara Zagora, 6000, Bulgaria
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UZ Leuven
Leuven, 3000, Belgium
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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430022, China
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Unity Hospital ICU and Trauma
Surat, Gujarat, 395010, India
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Universitaetsklinikum Erlangen
Erlangen, Bavaria, 91054, Germany
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Universitaetsklinikum Essen
Essen, North Rhine-Westphalia, 45147, Germany
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Universitaetsklinikum Frankfurt Goethe-Universitaet
Frankfurt am Main, Hesse, 60590, Germany
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Universitaetsklinikum Heidelberg
Heidelberg, Baden-Wurttemberg, 69120, Germany
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Universitaetsklinikum Schleswig-Holstein - Campus Kiel
Kiel, Schleswig-Holstein, 24105, Germany
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Universitaetsspital Zuerich
Zurich, 8091, Switzerland
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University of Kansas Medical Center Research Institute, Inc.
Kansas City, Kansas, 66160, United States
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University of Utah
Salt Lake City, Utah, 84112, United States
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University of Washington
Seattle, Washington, 98195, United States
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Varlik Mah. Kazim Karabekir Cad.
Muratpaşa, 07100, Turkey (Türkiye)
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Vojenska nemocnice Brno
Brno, Czechia
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West China Hospital, Sichuan University
Sichuan, China
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Wexner Medical Center
Columbus, Ohio, 43210, United States
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Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, 200082, China
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Yeovil District Hospital
Yeovil, Somerset, BA21 4AT, United Kingdom
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Yeungnam University Hospital
Daegu, Gyeongsangbuk-do, 42415, South Korea
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Yijishan Hospital of Wannan Medical College
Wuhu, Anhui, 241001, China
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Yonsei University Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, 26426, South Korea
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Zhongda Hospital Southeast University
Nanjing, Jiangsu, 210009, China
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Zhongshan Hospital Xiamen University
Xiamen, Fujian, 361004, China
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Zuyderland Medisch Centrum - Sittard-Geleen
Sittard, 6162 BG, Netherlands
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ongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
Wuhan, Hubei, 430030, China
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