Autoimmune disorder of gastrointestinal tract

This early-stage trial tests a single infusion of allogeneic CAR-T cells, called RN1201, in 18 adults with autoimmune diseases that have not responded to standard treatments. The therapy aims to reset the immune system by targeting and eliminating faulty immune cells. Before the …

Researchers at Sheba Medical Center are studying a tele-diabetes remote monitoring system for children and teens with type 1 diabetes. The system analyzes real-time glucose data from continuous monitors and sends automated WhatsApp alerts when it detects high or low patterns. The…

This study tests whether combining mycophenolate mofetil (MMF) with prednisone can better treat liver inflammation caused by checkpoint inhibitor cancer drugs. The trial includes adults with moderate to severe immune-related hepatitis who need to pause their cancer therapy. The m…

This study tests whether tirzepatide, a drug used for type 2 diabetes, can help people with type 1 diabetes. Researchers will measure how the body responds to insulin and meals before and after 6 weeks of treatment. 44 adults with type 1 diabetes who use an automated insulin pump…

This study tests whether a drug called AMX0035 can improve how the body responds to insulin in adults with type 1 diabetes. Participants take either AMX0035 or a placebo daily for 24 weeks. Researchers measure insulin sensitivity using a glucose clamp test and track blood sugar c…

This study tests a drug called teplizumab in people aged 1 to 25 who were recently diagnosed with type 1 diabetes. The goal is to see if teplizumab can help control blood sugar and reduce the need for insulin at mealtimes. Participants will receive either teplizumab or a placebo …

This study tests a new drug, CNP-103, in people aged 12 to 35 who were diagnosed with stage 3 type 1 diabetes within the last 6 months. The goal is to see if the drug is safe and can help control the disease. Participants will receive either the drug or a placebo, and researchers…

This study looks at whether changing the types of carbohydrates people with type 1 diabetes eat can improve blood sugar control. Researchers will compare a diet with more whole grains and beans to one with mostly refined grains. 80 adults will be monitored to see if the diverse c…

This study tests a next-generation automated insulin delivery system (Omnipod M) in up to 40 adults with type 1 diabetes. The goal is to see if the system safely improves blood sugar control by reducing dangerously low and high levels. Participants will use the device during hote…

This phase 2 trial tests whether ursodeoxycholic acid (UDCA), a drug already used for other liver conditions, can treat cholestatic hepatitis—a liver inflammation caused by immunotherapy—better than standard steroids. About 94 adults with cancer (excluding liver cancer) who devel…

Researchers are testing whether low-dose interleukin-2 (IL-2) can help people recently diagnosed with type 1 diabetes preserve their own insulin production. The trial enrolls 24 people aged 16 to 45 who still make some insulin. Participants first receive a two-month course of cyc…

This study compares two drugs, ATG and teplizumab, to see if they can delay or prevent type 1 diabetes in people who are at high risk. About 60 participants aged 4 to 35 will receive either two infusions of ATG or 14 daily infusions of teplizumab. Researchers will monitor them fo…

This study follows about 1,875 people aged 6 and older with type 1 diabetes who use the iLet Bionic Pancreas, an automated insulin delivery system. Over 12 months, researchers will track serious events like severe low blood sugar and diabetic ketoacidosis to see how the device pe…

This study tests whether a four-week education program can help adults with type 1 diabetes dose mealtime insulin using continuous glucose monitor (CGM) data instead of traditional carbohydrate counting. Participants are randomly assigned to either the C-Carbs program or usual ca…

This Phase 2 trial tests a drug called rezpegaldesleukin in people recently diagnosed with type 1 diabetes (within 100 days). The goal is to see if it can help the body keep producing some insulin, reducing the need for injected insulin. 66 participants will receive either the dr…

This study tests whether baricitinib, a pill, can help preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes. About 300 children and young adults (ages 1 to under 36) will take either baricitinib or a placebo for 60 weeks. The goal is to see i…

This trial tests whether verapamil, a blood pressure drug, can protect the pancreas cells that make insulin in children and teens newly diagnosed with type 1 diabetes. Participants aged 10 to 18 will take verapamil or a placebo daily for 24 weeks. Researchers will measure how muc…

This study tests whether giving a low dose of anti-thymocyte globulin (ATG) followed by either adalimumab or verapamil can help preserve the body's ability to make insulin in people aged 9 to under 21 who were recently diagnosed with type 1 diabetes. The main goal is to see if th…

This study tests a smartphone app called DailyDose that gives personalized advice on insulin doses and carbohydrate intake for people with type 1 diabetes who use multiple daily injections. The app uses data from continuous glucose monitors and insulin pens. Researchers want to s…

This study tests a treatment called VX-880 for people with type 1 diabetes who have dangerous low blood sugar episodes. The therapy uses donor cells that can produce insulin, aiming to let participants stop taking insulin shots and avoid severe hypoglycemia. About 52 adults with …

This study is testing a new tool called MODI, which is a smart algorithm that helps people with diabetes figure out the right amount of insulin to take. About 100 adults with type 1 or type 2 diabetes will use the MODI system along with a continuous glucose monitor for 13 weeks. …

This study compares a continuous glucose monitor (CGM) to standard fingerstick testing in 270 adults with type 1 or type 2 diabetes who use insulin injections. Participants wear the Accu-Chek SmartGuide sensor to track blood sugar levels continuously. The goal is to see if the CG…

This study follows 630 people with type 1 diabetes in Japan who are already prescribed Awiqli, a once-weekly injection. Researchers will track side effects and blood sugar control over one year to see how the drug works in everyday life. The goal is to manage diabetes, not cure i…

This trial tests a mobile health program called The 3Ms 2.0 for primary caregivers of Black adolescents with type 1 diabetes. The program uses interactive online sessions, video clips, and text messages to encourage daily parental monitoring of diabetes care. Researchers will com…

This study follows 1,000 people with Stage 2 Type 1 Diabetes who have received teplizumab in routine care. Researchers will track how long it takes for the disease to progress to Stage 3 and assess quality of life. The goal is to see if teplizumab delays the need for insulin ther…

This trial tests whether a silicone-based or a hydrocolloid patch placed under insulin pumps or glucose monitors can prevent contact dermatitis from coming back in children aged 2-18. Participants will use different patches and attend visits for skin exams, ultrasounds, and quest…

This study tests a new drug called SAB-142 in people recently diagnosed with type 1 diabetes. The goal is to see if it can help the body keep making its own insulin for longer, slowing the disease. About 159 people aged 5 to 40 will receive either the drug or a placebo, and resea…

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells enclosed in a protective capsule, for people with unstable type 1 diabetes who still experience severe low blood sugar episodes despite using an automated insulin pump and continuous glucose m…

This study tests a new drug called tegoprubart along with other medicines to help people with type 1 diabetes and chronic kidney disease receive pancreatic islet cell transplants. The goal is to see if this approach is safe and can improve blood sugar control without needing life…

This study tests whether using a diabetes management app alongside personalized nutrition counseling from a dietitian can help adults with insulin-requiring diabetes improve their blood sugar control, cholesterol, physical activity, and overall quality of life. Participants will …

This study tests an experimental drug called DONQ52 in people with active celiac disease who still have gut damage and symptoms even after following a gluten-free diet for at least a year. About 92 adults will receive either the drug or a placebo to see if it can heal the small i…

This study tests a program that delivers fresh produce to the homes of pregnant women with type 1 or 2 diabetes who also struggle to afford healthy food. Participants also get group classes on diabetes, nutrition, and cooking, plus help finding other resources. The goal is to see…

This study tests a new approach for teens (ages 10-17) recently diagnosed with type 1 diabetes. They will use an inhaled insulin called Afrezza along with a long-acting injected insulin. The goal is to see if this combination helps keep blood sugar in a healthy range and is safe …

This pilot study tests whether intermittent use of a continuous glucose monitor (CGM), along with regular medical visits, diabetes education, and psychological support, can improve blood sugar control in children and adolescents with high-risk type 1 diabetes in the Dominican Rep…

This study tests whether a low dose of glucagon, given before exercise, can prevent blood sugar drops in adults with type 1 diabetes who use an automated insulin pump. Eighteen participants will exercise after a meal, comparing glucagon to a standard glucose drink. The goal is to…

This phase 2 trial tests whether dulaglutide, a drug used for type 2 diabetes, can improve small blood vessel function in adults with type 1 diabetes. The study involves 47 participants aged 18-40 with long-standing type 1 diabetes. Researchers measure blood flow and insulin sens…

This study tests whether a medicine called Panzyga can prevent major infections in people with autoimmune or rheumatic conditions who have low antibody levels after receiving B-cell depletion therapy. About 360 adults will receive either Panzyga or a placebo, and researchers will…

This study tests whether an automated insulin delivery system (CamAPS FX) can help women with type 1 diabetes maintain better blood sugar control before and during pregnancy, compared to their usual insulin routine. The trial will enroll 305 women aged 18-45 who are either planni…

This study is testing a new wearable device that continuously measures both glucose (sugar) and ketone levels in adults with type 1 diabetes. The device is worn for 15 days and its readings are compared to standard lab tests. The goal is to see if it is accurate and safe enough f…

This study tests whether a nutrition program that provides twice-daily meal delivery for up to 90 days after hospital discharge, plus diet education, can reduce food insecurity in people with type 1 or type 2 diabetes. About 160 hospitalized patients who screen positive for food …

This early-stage study is testing a new treatment called GNTI-122 for adults who were recently diagnosed with type 1 diabetes. The therapy is made from a person's own blood cells and is designed to help rebalance the immune system. Sixteen participants will receive either a low o…

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after leaving the hospital helps people with diabetes who are starting insulin for the first time. About 150 adults with type 1 or type 2 diabetes will be randomly assigned to use either a CGM or…

This study tests whether a 12-week sleep-focused behavioral program can help adults with type 1 diabetes improve their sleep and blood sugar control. Participants learn sleep hygiene, stress management, and routines to target 7-9 hours of quality sleep. The study tracks sleep wit…

This study is testing a new implantable insulin pump (MIIPS 2020) in 40 adults with type 1 diabetes whose blood sugar is hard to control with standard insulin shots or external pumps. The pump is placed inside the body and delivers insulin directly, aiming to reduce dangerous hig…

This trial tests whether teaching children with celiac disease about nutrition and physical activity can improve their eating habits, growth, and quality of life. Children aged 8 to 12 who follow a gluten-free diet will be placed into one of three groups: one receiving both nutri…

This trial is testing whether semaglutide, a medication used for obesity, can improve heart health in young adults (ages 18-30) who have both type 1 diabetes and obesity. Participants will receive either semaglutide or a placebo for a year. The study will measure changes in body …

This study compares a new insulin pump system, Omnipod 6, to the current Omnipod 5 in 200 people with type 1 or type 2 diabetes who have poor blood sugar control. Participants will use both pumps for a set time to see which one helps keep blood sugar in a healthy range more effec…

This study looks at how well the Omnipod 5 Automated Insulin Delivery System works in real-world settings for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar levels in a h…

This trial tests whether an artificial intelligence system can help optimize insulin pump settings remotely for people with type 1 diabetes. The AI analyzes continuous glucose monitor and pump data to suggest personalized adjustments, which a doctor then reviews before sending to…

This study will test a new experimental automated insulin delivery system (called NMX8) in 116 people with type 1 or type 2 diabetes who need insulin. The goal is to see if the new system is safe and works as well as the current Medtronic 780G system at keeping blood sugar in a h…

This trial tests whether denosumab, a drug already used for bone conditions, can protect the beta cells that produce insulin in people with early type 1 diabetes. Researchers believe the same biological pathway that denosumab targets in bones may also help preserve beta cell func…

This trial tests whether GlycoQuest, a video game that connects to a continuous glucose monitor and adapts using artificial intelligence, can help children aged 6 to 17 who were diagnosed with type 1 diabetes in the past three months. The game includes a glucose-responsive avatar…

This study tests whether dimethyl fumarate, a drug already used for multiple sclerosis, can help preserve the body's ability to make insulin in adults with type 1 diabetes. About 96 people will either receive the drug plus standard insulin therapy or insulin alone for 24 weeks, t…

This study looks at whether adding pioglitazone (a type 2 diabetes drug) to dapagliflozin (an SGLT2 inhibitor) can reduce the liver's glucose production, fat breakdown, and ketone production in people with type 1 diabetes. These effects from dapagliflozin can raise the risk of ke…

This study enrolls 50 children and teens (ages 6 to under 18) with type 1 diabetes who have high blood sugar levels and come from low-income families. Participants will receive help from an insurance navigator to get a closed-loop insulin pump and continuous glucose monitor. The …

This study will look at whether a remote patient monitoring system, called Steno Detektor, helps people with diabetes control their blood sugar. About 12,000 patients will be monitored as part of their regular care. Researchers will compare blood sugar levels and hospital visits …

This study tests whether a combination of special immune cells (Tregs) and a drug (rituximab) can delay or prevent type 1 diabetes in children aged 6–16 who are at high risk but still produce insulin normally. About 150 participants will be randomly assigned to one of four groups…

This study tests whether inhaled insulin (Afrezza) given with a meal is safer than a standard pump insulin bolus for preventing low blood sugar during exercise afterward. About 30 adults with type 1 diabetes who use automated insulin pumps will complete three exercise sessions in…

This study compares three diets for weight loss in adults with type 1 diabetes who are overweight or obese. Participants will follow either a moderate carbohydrate restriction, an early time-restricted eating plan, or a standard calorie-restricted diet. The goal is to see which a…

This study tests a program to help new mothers with chronic conditions like high blood pressure, diabetes, or depression transition smoothly from obstetric to primary care after giving birth. The program includes automatically scheduling a primary care visit, sending personalized…

This study looks at whether automated insulin delivery (AID) systems can safely manage blood sugar during labor and delivery for pregnant people with type 1 diabetes. About 150 participants will be randomly assigned to use their usual AID system or standard intravenous insulin. T…

This study looks at how a new insulin pump system (mylife CamAPS FX with Dexcom G6 sensor) helps people with type 1 diabetes control their blood sugar and improve quality of life. About 125 adults and children in France will use the system for one year while doctors track their p…

This study tests whether teplizumab, a drug already approved in the US, can safely delay the start of full-blown type 1 diabetes in Japanese people aged 8 to 34 who are at high risk (Stage 2). Participants will receive a 14-day IV treatment and be monitored for side effects and h…

This study will follow 2,200 children and adults with type 1 diabetes who are using the Omnipod 5 system, a tubeless insulin pump that automatically adjusts insulin based on continuous glucose monitor readings. Over 12 months, researchers will track how often severe low or high b…

This study looks at whether adding GLP-1 receptor agonists or SGLT inhibitors to insulin helps adults with type 1 diabetes manage their blood sugar better. Researchers will track 300 participants for one year, measuring changes in HbA1c and other health markers. The goal is to se…

This early-stage trial tests whether TIX100, a daily oral pill, is safe and tolerable in healthy adults who are overweight or obese. Over 28 days, participants receive either TIX100 or a placebo, and researchers monitor for side effects and how the drug moves through the body. Th…

This study tests whether montelukast, a common allergy medication, can lower protein levels in urine and improve kidney and blood vessel function in people with type 1 diabetes who have early signs of kidney disease. Inflammation is thought to play a role in diabetic kidney damag…

This study tests a new care model for 80 young adults with type 1 diabetes who are moving from pediatric to adult healthcare. The program includes a nurse educator, psychologist, and transition navigator working together to provide support over six months. The goal is to see if t…

This study looks at whether a second islet transplant can safely improve blood sugar control in adults with type 1 diabetes whose first transplant stopped working. Researchers will follow 20 patients for up to 5 years, checking graft function, insulin use, and severe low blood su…

This study is testing a new blood filter called the Plasma Filter PX2. It is used in a procedure called therapeutic plasma exchange, which removes harmful substances from the blood of people with autoimmune diseases. About 46 adults will take part, and the study will check if the…

This study is testing a mobile app called Adhera Caring Digital Program for Obesity (ACDP-O) in 280 families. The app provides personalized education, mental health monitoring, and wearable device integration to support weight management and well-being in adolescents and young ad…

This early-stage trial tests a new medicine called VTP-1000 in 45 adults with celiac disease. The goal is to see if it is safe and how the body handles it, especially when exposed to gluten. Participants will receive either the drug or a placebo, and some will take a controlled g…

This study tests whether betaine hydrochloride, a dietary supplement, can safely lower high gastrin levels in people with autoimmune gastritis. High gastrin is linked to an increased risk of stomach tumors. Sixty participants will receive either betaine or a placebo before meals …

This study is testing whether a portable gluten-detection device, combined with regular telemedicine check-ins with a dietitian, can improve gut healing in adults newly diagnosed with celiac disease. Two hundred participants will use the technology and receive expert guidance to …

This study looks at whether a plant-based (vegan) diet can help children with autoimmune hepatitis achieve disease remission. Researchers will compare a vegan diet to a standard high-protein diet over 180 days in 40 newly diagnosed children. The goal is to see if diet changes can…

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to standard care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device for 13 weeks or continue their usual routine. The goal is to see if the devic…

This study tests a digital tool that helps children under 12 with type 1 diabetes calculate their insulin doses. The tool considers factors like carbs, blood sugar levels, and trends. Researchers will compare blood sugar control (HbA1c) over 6 months between kids using the tool p…

This early-phase study tests whether dichloroacetate (DCA), a drug used safely for decades in a rare metabolic disorder, can improve brain function during low blood sugar (hypoglycemia) in people with type 1 diabetes. Sixteen participants with a history of severe hypoglycemia or …

This early-stage study is testing a new insulin pill (SCD0503) in 16 men with type 1 diabetes. The goal is to see how well the pill works compared to standard injected insulin and whether it is safe. Participants will have their blood sugar carefully controlled during the study t…

This early-stage trial tests a new drug called NNC0497-0040 in healthy people, those with overweight or obesity, and people with type 1 diabetes who are also overweight. The goal is to see if the drug is safe and tolerable when given as a weekly injection. About 146 participants …

This study is testing whether semaglutide, a drug already used for type 2 diabetes, can reduce kidney damage in people with type 1 diabetes and diabetic kidney disease. About 60 adults will receive either semaglutide or a placebo for 26 weeks. Researchers will measure changes in …

This study tests whether tirzepatide, a weekly injection already used for type 2 diabetes, can help adults with type 1 diabetes use an automated insulin pump without needing to count carbohydrates at meals. About 105 participants will be randomly assigned to receive tirzepatide o…

This early-stage study tests a new drug called MTX-101 in healthy adults and people with type 1 diabetes. The main goal is to check for side effects, see how long the drug stays in the body, and learn how it affects immune cells. About 96 participants will receive either a single…

This study looks at whether regular exercise can improve how well blood vessels work in adults with type 1 diabetes who do not yet have complications. About 34 participants will be randomly assigned to an exercise program or usual care. The main goal is to see if exercise helps b…

This study tests whether taking omega-3 supplements (2.4 grams daily for 3 months) can lower inflammation and improve intestinal healing in adults newly diagnosed with celiac disease. Participants will also follow a gluten-free diet. The goal is to see if adding omega-3s helps mo…

This study tests a 16-week behavioral program called T1DAL, designed specifically for teens with type 1 diabetes who have overweight or obesity. About 50 teens will be randomly assigned to either the program or usual care. The program includes virtual group sessions and one-on-on…

This study tests whether taking a probiotic called Desulfovibrio piger for 4 weeks can lower inflammation and help preserve the body's own insulin production in people who have had type 1 diabetes for more than 5 years. Twenty adults with remaining beta cell function will receive…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study tests a stem cell transplant for people with common variable immunodeficiency (CVID) and other immune disorders. The goal is to replace the faulty immune system with a healthy donor's stem cells. Participants are aged 5 to 40 and will receive a reduced-intensity transp…

This study tests whether a special type of iron supplement (Sucrosomial iron) helps children with celiac disease who also have low iron or anemia. The trial will compare children who take the supplement plus a gluten-free diet to those who only follow the diet. The goal is to see…

This study follows 350 people with type 1 diabetes in France who use the Control-IQ insulin pump system. Researchers want to see how safe and effective the system is over 12 months, focusing on blood sugar control and quality of life. Participants must be at least 6 years old and…

This study tests whether taking a prebiotic fibre supplement for 6 months can help people with type 1 diabetes have fewer dangerous low blood sugar episodes. Researchers will also see if it improves overall blood sugar control and gut health. The study involves 144 people aged 7 …

This study tests whether the drug ZT-01 can reduce nighttime low blood sugar (hypoglycemia) in adults with type 1 diabetes. Participants will inject ZT-01 or a placebo before bed for two 4-week periods while wearing a continuous glucose monitor. The goal is to see if ZT-01 lowers…

This study looks at two ways of managing blood sugar during labor in pregnant women with type 1 diabetes. One group will follow a strict target (70-110 mg/dL), while the other will have a more relaxed target (70-140 mg/dL). The goal is to see if the relaxed approach is safe for n…

This study tests whether adding belimumab to standard therapy can better control autoimmune hepatitis, a chronic liver disease. About 48 adults with active or stable disease will receive weekly injections for 72 weeks. The goal is to reduce liver inflammation and lower the need f…

This study is testing a new continuous glucose monitoring system called ROME GS in 60 adults with type 1 or type 2 diabetes. The goal is to see if it measures blood sugar accurately and is safe to use. Participants will wear the sensor and have their glucose levels checked agains…

This study tests whether frequent, short virtual visits with diabetes educators can help adults with type 1 diabetes improve their blood sugar control. 580 participants will receive video check-ins every 1-3 weeks for 6 months, plus access to online education tools. The goal is t…

This study is testing a new glucose monitoring system called Eversense Gemini, which includes a flash glucose measurement feature. The goal is to see how accurate and safe it is for adults with type 1 or type 2 diabetes. About 80 participants will wear the device and have their g…

This study tests tirzepatide, a medication already used for obesity, in 60 adults who have both type 1 diabetes and obesity. Participants will receive either tirzepatide or standard care to see if it helps with weight loss and is safe. The goal is to understand if this drug can b…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This early-phase trial tests a single infusion of genetically modified immune cells (CAR-T cells) designed to target and calm the immune attack that causes type 1 diabetes. Nine adults with early-stage type 1 diabetes will receive the cells and be monitored for safety, insulin ne…

This study follows 200 people with stage 2 type 1 diabetes (early, no symptoms yet) who are taking TZIELD to delay the disease from getting worse. Researchers will watch for side effects over time, including serious infections and allergic reactions. The goal is to make sure the …

This phase 2 trial is testing a drug called MTX228 (Tolimidone) in 24 adults with type 1 diabetes who still produce some insulin. The goal is to see if the drug can help regrow the beta cells that make insulin, which could lower the amount of insulin they need to inject and impro…

This study follows 120 Israeli children and teens with type 1 diabetes who use the Medtronic 780G system, a closed-loop insulin pump that automatically adjusts insulin. Researchers will track blood sugar control, sleep, diet, and emotional well-being over two years. The goal is t…

This study tests a new drug called OPT101 in adults diagnosed with type 1 diabetes within the last 20 years. Participants receive injections three times a week for up to one year. The goal is to see if OPT101 can safely help the body keep making its own insulin, reducing the need…

This study tests whether a daily tablet called sotagliflozin can improve quality of life for people with both type 1 diabetes and heart failure. Researchers will give 320 participants either the drug or a placebo for 4 months, then compare symptoms like breathlessness and tiredne…

This study tests an oral drug called ZED1227 in 356 adults with celiac disease who still have symptoms like stomach pain and bloating even after following a gluten-free diet for at least a year. Participants will receive either the drug or a placebo for several weeks to see if sy…

This study tests whether automated insulin pumps (hybrid closed loop systems) can help underserved adults with type 1 diabetes better control their blood sugar. About 140 participants will be randomly assigned to use one of three FDA-approved pump systems or continue with standar…

This study tests whether a daily pill called sotagliflozin can slow kidney function loss in people with type 1 diabetes who already have moderate to severe kidney disease. About 150 participants will take either the drug or a placebo for 3 years, while following a special plan to…

This early-stage study tests a new mRNA-based treatment (ABO2203) for people with autoimmune diseases that haven't improved with standard care. The therapy works by directing the body's immune cells to attack and control overactive immune cells causing the disease. The study will…

This phase 3 study tests VX-880, a stem-cell therapy infused into the liver, in 10 people with type 1 diabetes who have already received a kidney transplant. The main goal is to see if participants can stop using insulin entirely. The therapy is given alongside standard transplan…

This study follows up to 30 people with type 1 diabetes who previously received islet cell transplants. Researchers want to see how long the transplanted cells keep working to control blood sugar. Participants must continue taking immunosuppressive drugs to prevent rejection.

This study looks at whether closely monitoring patients with mild to moderate liver inflammation from cancer immunotherapy, and only giving steroids if needed, is as safe and effective as starting high-dose steroids right away. About 56 adults with grade 2 or 3 immune-related hep…

This study tests whether the drug Myfortic can prevent the immune system from becoming sensitized after a failed islet transplant in people with type 1 diabetes. Participants have already lost their graft and will take Myfortic alone for two years. The goal is to see if this redu…

This study tests whether a special adhesive patch (COVER PATCH) can help keep continuous glucose monitors (CGMs) stuck to the skin for their full recommended wear time. About 194 people with type 1 or type 2 diabetes, aged 6 and older, will either use the patch or not for 4 month…

This study tests a two-step transplant for children with type 1 diabetes who also have an immune deficiency. First, they receive umbilical cord blood stem cells to rebuild their immune system. Then, if that works well, they get a transplant of insulin-producing islet cells. The g…

This study is testing whether a high-fiber supplement called Trimtab can help preserve beta-cell function in children aged 6 to 12 who were recently diagnosed with type 1 diabetes. For 12 weeks, participants will take the supplement daily, and researchers will measure C-peptide l…

This study tests whether a very-low-carbohydrate (ketogenic) diet can safely improve blood sugar control in adults with type 1 diabetes. Researchers will enroll 58 people and measure changes in blood sugar levels and insulin sensitivity. Participants will follow the diet for a pe…

This study tests whether a 15-minute brisk walk, taken right after a missed insulin dose, can prevent high blood sugar in people with type 1 diabetes. Researchers will compare blood sugar levels in 30 adults aged 18-24 who either take insulin before a meal, after a meal, or after…

This early-phase trial tests transplanting insulin-producing cells into the front chamber of the eye in legally blind people with diabetes. The goal is to see if the cells survive and work safely using only eye drops for immune suppression. Only 2 participants are enrolled, so th…

This study tests whether dimethyl fumarate, a drug already used for multiple sclerosis, can protect the pancreas's insulin-producing cells in adults recently diagnosed with type 1 diabetes. Ninety participants will take either the drug or a placebo twice daily for 24 weeks, along…

This phase 3 trial is testing whether semaglutide, a drug already used for type 2 diabetes and weight loss, can improve heart and kidney function in adults with type 1 diabetes. The study will measure artery stiffness, insulin sensitivity, and kidney blood flow in 60 participants…

This study tests whether combining automated insulin pumps (Omnipod 5 or Medtronic 780G) with specialized education can help adults with type 1 diabetes who have lost the ability to feel low blood sugar (hypoglycemia). The trial will enroll 324 participants and follow them for up…

This study tests whether adding a natural gut hormone called gastrin to islet cell transplants can help people with hard-to-control type 1 diabetes produce their own insulin and stabilize blood sugar. About 20 adults aged 18-68 with unstable type 1 diabetes will receive donor isl…

This study tests whether an artificial pancreas system can improve blood sugar control and, in turn, reduce heart disease risk in people with type 1 diabetes. The system combines an insulin pump with a continuous glucose monitor to mimic a healthy pancreas. Researchers will measu…

This study tests whether a new drug called CIR-0602K can help people with type 1 diabetes keep their blood sugar in a healthy range and reduce their insulin needs. The trial involves 40 adults aged 18-45 who already use an automated insulin pump. Half will get the drug and half a…

This expanded access program offers a stem cell transplant using donor cells that have been specially processed to remove certain immune cells, reducing the risk of graft-versus-host disease. It is for patients with serious blood disorders, immune deficiencies, or metabolic disea…

This study tests whether the Medtronic 780G automated insulin pump can improve blood sugar control in adults with type 1 diabetes who also have gastroparesis (stomach paralysis). Participants will use the device for three months, and researchers will measure how often blood sugar…

This early-phase trial is testing a new treatment called CELZ-201 for people recently diagnosed with type 1 diabetes. The treatment involves a one-time infusion of cells from donated tissue into the pancreas. The main goal is to see if it is safe, but researchers will also check …

This study looks at whether using ultrasound to find fatty lumps (lipohypertrophy) caused by insulin injections can help people with diabetes improve their blood sugar levels. About 50 adults with type 1 or type 2 diabetes who use insulin and a continuous glucose monitor will get…

This study aims to see if a hybrid closed-loop insulin pump (a smart insulin pump) can help adults with poorly controlled type 1 diabetes (A1c >8.5%) from diverse backgrounds. The study will enroll 40 participants from Los Angeles who do not currently use an insulin pump. The goa…

This study tests whether a single infusion of arginine hydrochloride, a natural amino acid, can help people with type 2 diabetes recover faster from diabetic ketoacidosis (DKA), a serious complication. Sixty adults arriving at emergency rooms with DKA will receive either arginine…

This Phase 3 trial is testing a drug called Neovasculgen, given as injections into the leg muscles, to see if it can help heal foot ulcers in people with diabetes. The study will include 144 adults with type 1 or type 2 diabetes who have a non-healing foot ulcer. Participants wil…

This study tests whether using a continuous glucose monitor (CGM) helps kidney transplant recipients with type 2 diabetes keep their blood sugar in a healthy range. Eighty adults who received a kidney transplant within the past year and use insulin will wear a Dexcom G6 sensor th…

This study tests whether adding a weekly medicine called tirzepatide to usual insulin therapy helps adults with type 1 diabetes control their blood sugar better. About 42 people aged 18-65 who already use an automated insulin pump will take part. The goal is to see if the combina…

This early-stage study tests an experimental drug called LY3938577 in healthy volunteers and people with type 1 diabetes. The main goals are to see how the body processes the drug and whether it can safely lower blood sugar. The study has four parts, comparing the drug to insulin…

This study is tracking 1,875 people with type 1 diabetes (ages 6 and up) who are already using the Twiist automated insulin delivery system. Researchers are monitoring for severe low blood sugar events, diabetic ketoacidosis, and hospitalizations related to the device. The goal i…

This study tracks 50 children and adults with non-malignant disorders like immune deficiencies and anemias who receive a stem cell transplant after a reduced-intensity chemotherapy regimen. The goal is to see if this approach improves survival and reduces severe graft-versus-host…

This study tests a program called T1CARE, where a community health navigator helps young adults with type 1 diabetes address social needs like housing, food, and healthcare access. 100 participants will be randomly assigned to get the navigator right away or after a wait. The goa…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This study is testing a mobile app called glUCModel that uses artificial intelligence to predict glucose levels and help people with type 1 diabetes decide how much insulin to take. About 34 adults aged 18 to 65 will use the app for several weeks while wearing a continuous glucos…

This study is testing a new automated insulin delivery system for adults with type 1 diabetes. The system uses a patch pump and a smart algorithm to adjust insulin automatically. Researchers will check if it improves blood sugar control and is safe to use in daily life. 200 parti…

This study tests a program called AHEAD that helps young people aged 16-19 with type 1 diabetes improve their blood sugar control as they move from pediatric to adult care. About 306 participants will either get usual care or the AHEAD program, which offers tailored support to bu…

This study tests whether colchicine, a drug used for gout, can improve how the body uses insulin in people with type 1 diabetes who have low-grade inflammation. 26 adults will receive either colchicine or a placebo for four weeks, and their insulin sensitivity will be measured us…

This study tests whether a 12-week sleep improvement program can help adults aged 18-40 with type 1 diabetes manage their blood sugar and reduce distress. Participants will receive coaching based on motivational interviewing and behavior change techniques. The study will track sl…

This study tests a weekly injection of semaglutide (a GLP-1 drug) in 76 adults with 'double diabetes' — a mix of type 1 diabetes and inherited insulin resistance. The goal is to see if the drug improves blood sugar control and helps with weight loss. Participants must be over 18,…

This study looks at whether adding a GLP-1 drug (semaglutide, sold as Rybelsus®) to the standard teplizumab treatment can help control blood sugar and improve blood vessel function in people with early stage type 1 diabetes. Researchers will give 24 participants a liquid meal tes…

This study tests whether giving teens with type 1 diabetes financial rewards for meeting blood sugar goals improves their diabetes management. About 96 teens will either get usual care or earn money for hitting targets. Researchers will compare blood sugar levels and quality of l…

This study is testing a less intense chemotherapy and radiation regimen before a stem cell transplant for children and young adults up to age 55 with non-cancerous blood disorders like immune deficiencies, anemias, and metabolic diseases. The goal is to see if this gentler prepar…

This study tests whether personalized nutrition education on a healthy Nordic diet can improve blood sugar control in adults with type 1 diabetes. 54 participants will either receive this education or standard brief dietary advice. The main goal is to see if the intervention incr…

This study tests whether transplanting insulin-producing islet cells from deceased donors can help people with brittle type 1 diabetes achieve safer blood sugar control without insulin shots. Up to 20 adults aged 18–70 with long-standing type 1 diabetes will receive the cells thr…

This phase 2 trial tests whether transplanting insulin-producing islet cells from deceased donors can help people with type 1 diabetes who have already received a kidney transplant. The goal is to achieve safe blood sugar levels without insulin shots. Ten participants will receiv…

This study looks at whether a community health worker (CHW) can act as a diabetes technology coach for Black children with type 1 diabetes who use an automated insulin delivery system but still have high blood sugar (HbA1c of 8% or higher). Over 6 months, families meet monthly wi…

This phase 2 trial tests whether a low dose of anti-thymocyte globulin (ATG), followed by verapamil, can help preserve the body's ability to produce insulin in adolescents and young adults recently diagnosed with type 1 diabetes. The study will enroll 60 people aged 6 to 35 who h…

This study is testing whether a flash continuous glucose monitor (CGM) can help children and young adults in Uganda with type 1 diabetes keep their blood sugar in a healthy range more often than standard finger-prick testing. Half of the 180 participants will use the CGM for the …

This early study tests whether siplizumab, given at the time of liver transplant, can safely prevent the immune system from attacking the new liver. Up to 8 adults with autoimmune hepatitis or primary sclerosing cholangitis will receive two doses. The main goal is to check for se…

This early-stage trial is testing a new long-acting insulin called GZR33 in 12 adults with type 1 diabetes. The goal is to see how well it controls blood sugar compared to an existing insulin, degludec, and to check its safety. Participants will receive both insulins at different…

This study tests a new biologic drug called FB102 in 100 adults with celiac disease who already follow a strict gluten-free diet. Participants will receive either FB102 or a placebo and then undergo a controlled gluten challenge to see if the drug can reduce intestinal damage and…

This study compares having one laser treatment versus several sessions for a serious diabetic eye condition that can cause blindness. Researchers want to see which approach is safer and works better. The study will involve 40 adults with type 1 or type 2 diabetes who have this ey…

This study tests whether using a Dexcom G7 continuous glucose monitor (CGM) instead of standard fingerstick blood sugar checks leads to better blood sugar control and fewer dangerous lows in hospitalized adults with type 1 diabetes. One hundred participants will be randomly assig…

This study tests whether a sleep coaching program can help 150 teens (ages 11-17) with type 1 diabetes sleep longer and more consistently. Participants will receive either sleep coaching or standard diabetes education. Researchers will measure sleep with a Fitbit, check blood sug…

This study is testing whether verapamil, a drug used for high blood pressure, can help children aged 4 to 9 with newly diagnosed type 1 diabetes keep making some insulin. The trial has two parts: first, 6 children will take verapamil to check safety; then, 30 more children will b…

This study tests whether a very low-calorie ketogenic diet (600-800 calories per day) can help people with type 1 diabetes and obesity lose weight safely. Fourteen adults will follow the diet for 4 weeks while using an automated insulin pump. The main goal is to see how much weig…

This study tests whether an online training and support platform can help adults with type 1 diabetes better manage their blood sugar and well-being. About 322 participants across Canada will use the platform for 12 months, either as part of their usual clinic care or on their ow…

This study tests whether an online training and peer support platform (Support-t) helps teens with type 1 diabetes prepare for the move from pediatric to adult healthcare. About 200 teens aged 14-16 will either use the platform plus usual care or just usual care. The main goal is…

This early-stage trial tests a new treatment called RGB-5088 for people with type 1 diabetes. It involves transplanting insulin-making cells under a muscle layer in the abdomen. The goal is to see if it is safe and if it can help patients control blood sugar without insulin shots…

This study looks at whether low-dose prednisolone (a steroid) can safely treat liver inflammation (hepatitis) caused by immune checkpoint inhibitors in cancer patients. Researchers will enroll 63 adults with grade 2 or 3 immune-related hepatitis and give them 0.5-1 mg/kg of predn…

This study is testing whether transplanting gut bacteria from healthy donors into people with type 1 diabetes can help control blood sugar and reduce insulin needs. Fifty participants will receive three doses of washed microbiota through the gastrointestinal tract. Researchers wi…

This study is testing whether a specially designed digital game can help children aged 8-13 with type 1 diabetes improve their blood sugar control, confidence in managing their diabetes, and overall quality of life. The game is based on a health education model and will be played…

This study tests whether a comprehensive management program—including a specialized diabetes team, structured education, peer support, and modern diabetes technology like insulin pumps and continuous glucose monitors—can improve blood sugar control in people with type 1 diabetes.…

This study is testing an artificial intelligence tool called Tia Bete that helps people with type 1 diabetes count carbohydrates and adjust their insulin doses in real time. Researchers will enroll 50 participants (children and adults) and track their blood sugar control, quality…

This study is testing whether a combined autoantibody test on a drop of blood from a finger prick (dried on special paper) can detect type 1 diabetes as accurately as the standard blood draw from a vein. The researchers will enroll 106 children newly diagnosed with type 1 diabete…

This study aims to identify people at increased risk of developing type 1 diabetes by testing for specific markers in the blood called autoantibodies. Children and adults aged 1 to 45 who have a family member or close friend diagnosed with type 1 diabetes before age 45 can join. …

This trial evaluates a new continuous glucose monitoring (CGM) system in adults with type 1 diabetes. Participants will wear the sensor for 14 days while their blood sugar is measured against standard lab tests to see how accurate and safe the device is across different glucose l…

This early study tests a single oral dose of HB-2121 in 20 adults with suspected celiac disease. The dye is given four hours before a standard endoscopy to see how it interacts with the small intestine and whether it is safe. Researchers will track side effects and measure the dy…

This study will test whether artificial intelligence (AI) can effectively screen for diabetic retinopathy (eye damage) in 400 children with type 1 diabetes. Each child will have their eyes examined using an AI-powered camera, standard eye exams, and a detailed scan. The researche…

This study evaluates whether a blood test measuring polyreactive immunoglobulin G (pIgG) can more accurately diagnose autoimmune hepatitis (AIH) and distinguish it from other liver conditions. Researchers will collect blood samples from 400 adults undergoing liver biopsy for susp…

This study tests a small, noninvasive device that analyzes breath to detect high and low blood sugar events in children and young adults with diabetes. Participants aged 7–25 who already use a continuous glucose monitor will provide breath samples during normal, high, and low blo…

This study tests whether using an AI-driven retinal camera during regular diabetes checkups can increase the number of young people screened for diabetic retinopathy, a leading cause of blindness. Researchers will enroll 500 youth with type 1, type 2, or cystic fibrosis-related d…

This study is testing a new real-time continuous glucose monitoring (CGM) system to see how accurate and safe it is for adults with type 1 diabetes. About 82 participants will wear the device, and its readings will be compared to standard lab measurements. The goal is to improve …

This study is testing a new scoring system called OC26 to help doctors more accurately diagnose autoimmune pancreatitis, a condition where the immune system attacks the pancreas. Researchers will review medical data from 82 adults suspected of having the disease. If the OC26 crit…

This study tests whether a wearable breath sensor can detect high or low blood sugar in teens with type 1 diabetes. Participants wear the device for 72 hours and provide breath samples while checking blood sugar with a finger prick. The goal is to see if breath chemicals can repl…

This study from the University of Oxford is testing whether a finger-prick blood test, done at home, can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard OGTT requires a vein drip and mult…

This study is testing how well a new continuous glucose monitor, called CareSens Air 3, measures blood sugar levels in adults with type 1 diabetes. Researchers will compare the monitor's readings to standard lab measurements. The goal is to see if the device is accurate and preci…

This study tests whether a self-administered fingerstick glucose tolerance test done at home can accurately measure blood sugar levels compared to the standard clinic-based test. Researchers will enroll 60 people at risk for or recently diagnosed with type 1 diabetes. If accurate…

This study will collect capsule endoscopy images from 10,000 patients to train an artificial intelligence system to detect bowel diseases, Crohn's disease, celiac disease, chronic diarrhea, and tumors. The goal is to improve diagnostic accuracy and reduce the time doctors spend r…

This study is testing whether an artificial intelligence system can help doctors find signs of damage in the small bowel during endoscopy. The AI is trained to spot atrophy and other abnormalities linked to celiac disease and similar conditions. Researchers will compare the AI's …

This study is translating and testing a questionnaire called PainPREDICT for Thai-speaking people with diabetes. The goal is to create a mobile app that can screen for painful diabetic neuropathy, a common complication that causes nerve pain. Researchers will check if the Thai ve…

This study tests whether the drug baricitinib can delay the onset of type 1 diabetes in children aged 1 to 36 months who are at high risk. Participants take baricitinib or a placebo daily for up to 5 years. The goal is to see if the drug can push back or prevent the need for insu…

This study tests if special sensor-equipped insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. About 400 high-risk participants will use the insoles alongside standard care or just standard care alone. The goal is to see if the insoles…

This study tests whether intensive diet and physical activity counseling from 3 months to 2 years of age can protect the pancreas in infants with a genetic risk for Type 1 diabetes. About 1,244 babies will be randomly assigned to receive the counseling or standard care, and resea…

This study is testing whether the shingles vaccine (RZV) works and is safe for adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus who are taking immune-suppressing drugs. Two hundred participants will receive two doses of the vaccine. Researchers will me…

This study tests whether giving the COVID-19 vaccine (Comirnaty) to children starting at 6 months old can lower their chance of developing type 1 diabetes. The trial will include 2,252 children who have a high genetic risk for the disease. Half will get the vaccine, half a placeb…

Researchers test whether adding a predictive app to a continuous glucose monitor changes fear of low blood sugar, sleep quality, and diabetes distress in adults with type 1 or insulin-treated type 2 diabetes. Participants use the monitor alone for two weeks, then with the app for…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help people with type 1 diabetes who also have eating disorders. Participants will be randomly assigned to ACT, supportive diabetes counseling, or a waitlist. The goal is to see if …

This study tests a mobile health program called R2D2 designed to reduce diabetes distress in children aged 8-12 with type 1 diabetes and their parents. The program uses cognitive behavioral therapy, mindfulness, and behavioral strategies to help families cope. Researchers will me…

This study tests a three-session training program to help older adults (65+) who use insulin learn to use a continuous glucose monitor (CGM). Participants will be randomly assigned to the program or standard training. The goal is to see if the program improves how often they wear…

This study tests whether a gamified education program can improve health literacy and quality of life in children aged 8-12 with type 1 diabetes. Half of the 52 participants will receive the gamified program plus standard education, while the other half gets standard education al…

This pilot study tests whether a new, faster radiation planning method can safely ease severe abdominal pain caused by advanced cancer. Instead of a separate planning session, doctors use existing scans to create a treatment plan on the spot. Only 5 people will take part, and the…

This study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) who also have depression. Ten participants will meet with a boar…

This study tests whether a single, one-on-one session focused on depression can help teens with type 1 diabetes feel better and improve their blood sugar levels. Eighty teens aged 11-18 with mild depression will either get the special session or standard diabetes education. Resea…

This study tests a mobile app that gives personalized exercise coaching and feedback on blood sugar, sleep, and mood to help middle-aged adults with type 1 diabetes exercise more. Participants get a free Garmin smartwatch and program membership. The goal is to see if the app help…

This study tests whether pairing teens with type 1 diabetes with a young adult peer mentor can help them become more physically active and improve their quality of life. The 12-week program includes in-person, virtual, and text-based support. Researchers will measure how well the…

This study tests a group-based program called Supporting Teen Problem Solving (STePS) designed to reduce diabetes-specific emotional distress in teenagers with type 1 diabetes. The program is based on cognitive-behavioral and problem-solving approaches. Researchers will enroll 36…

This study compares a psychological therapy program called ACT1VATE to standard diabetes education in 250 adults with type 1 diabetes who have high emotional distress and poor blood sugar control. The therapy is delivered in five group sessions via video call. Researchers will me…

This study is testing a serious video game designed to improve emotional well-being in teenagers aged 12 to 16, both with and without chronic conditions like type 1 diabetes, asthma, and allergies. The game uses artificial intelligence to personalize activities that build coping …

This study tests a nutrition education program for children ages 2 to 18 recently diagnosed with celiac disease. The program focuses on eating naturally gluten-free foods and avoiding ultra-processed gluten-free options. Researchers will compare this approach to standard gluten-f…

This study compares a Mediterranean diet to a Western diet to see which one better reduces fatigue in people with autoimmune hepatitis. About 48 adults will try both diets in a random order. Researchers will measure changes in fatigue and quality of life using a standard question…

This study looks at whether eating a special artisanal bread made with whole wheat flour and sourdough can reduce stomach discomfort in people who usually feel sick after eating regular bread. Forty adults who are intolerant to conventional bread but do not have celiac disease wi…

This study tests whether a special toothpaste and mousse can reduce tooth sensitivity and enamel damage in adults with celiac disease. Forty participants will either use the toothpaste alone or add a nightly mousse for six months. Researchers will measure changes in sensitivity, …

This study tests a group-based psychological program called ACTnow for emerging adults (ages 18-35) with type 1 diabetes who feel overwhelmed by their condition. The program includes six bi-weekly sessions led by a psychologist and nurse, focusing on mindfulness and acceptance st…

This phase 2 trial tests whether metoclopramide, a drug currently used for stomach issues, can restore the ability to feel low blood sugar symptoms in people with type 1 diabetes. About 36 participants will take either the drug or a placebo for four weeks. Researchers will measur…

This study tests whether a four-week online self-compassion course can reduce diabetes-related distress, self-criticism, and shame in adults with type 1 or type 2 diabetes. Researchers will enroll 50 participants to see if the program is feasible and acceptable. The course includ…

This study tests a program that gives people with diabetes a continuous glucose monitor (CGM) when they leave the hospital. The goal is to see if it makes patients more satisfied and improves their quality of life. About 37 adults with Type 1 or Type 2 diabetes who use insulin wi…

This study tests whether a daily probiotic drink called Symprove can relieve ongoing gut symptoms like bloating, pain, and diarrhoea in adults with coeliac disease who already follow a strict gluten-free diet. About 24 participants will take the probiotic and report symptom chang…

This early-stage study tests a new drug called LY4057996 in 124 healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. Participants receive the drug as a shot under the skin or into a vein, and…

This study looks at whether using a continuous glucose monitor (CGM) after hospital discharge helps people with diabetes feel more in control and satisfied with their care. About 60 adults with type 1 or type 2 diabetes who need insulin will use a CGM at home and answer questionn…

This study tracks how well a nerve block procedure called celiac plexus neurolysis (CPN) helps manage pain in people with chronic pancreatitis. Researchers will follow 35 patients for 24 weeks, recording their pain scores and pain medication use. The goal is to see if the procedu…

This study tests a mindfulness app called Calm Health in 10 young adults (ages 18-30) with type 1 diabetes or similar conditions. Participants use the app to track mindfulness, blood sugar, stress, and sleep, and get personalized feedback. The goal is to see if the app is easy to…

This study tests whether cognitive behavioral therapy for insomnia (CBTi) can improve sleep, blood sugar levels, and quality of life in adults with type 1 diabetes. Fifteen participants will either receive 8 virtual CBTi sessions or health education emails and calls over 12 weeks…

This study explores whether removing wheat and cow's milk from the diet can reduce inflammation and improve skin symptoms in people with mild-to-moderate psoriasis. 82 participants will follow either a wheat- and dairy-free diet or a control diet for 2 months, then some will be r…

This study tests a virtual peer support program for people with type 1 diabetes and their loved ones across Canada. Participants join small online meetings and larger webinars to share experiences and reduce diabetes distress. The program is designed by researchers who also live …

This pilot trial tests the Discovery Program, a 3-month behavioral intervention for adolescents and young adults with type 1 diabetes. The program combines patient surveys, in-clinic goal setting, and personalized text messages to help improve blood sugar control and reduce diabe…

This study tests a new NHS pathway to help adults with type 1 diabetes manage diabetes distress—the worry, frustration, and burnout that often comes with the condition. The pathway trains healthcare teams to recognize and discuss distress during routine visits, and offers an onli…

This study tests whether a special type of talk therapy, delivered via video calls, can reduce anxiety and depression in young adults (ages 18-64) with type 1 diabetes. The therapy also includes reviewing continuous glucose monitor data to help link emotions and blood sugar level…

This study compares two virtual group programs—one focused on emotions, the other on problem-solving—to help adults with type 1 diabetes reduce diabetes distress. Participants who don't improve can get extra one-on-one sessions. The goal is to find better ways to support emotiona…

This study tests whether a structured education program, combined with regular follow-up visits, can help adults with type 1 diabetes better control their blood sugar. Researchers at Peking University First Hospital will enroll 150 participants and provide courses on diet, exerci…

Researchers want to learn how the body's own remaining insulin production, measured by a marker called C-peptide, affects quality of life and health outcomes in people with insulin-treated diabetes. The study follows about 700 adults, including some from a previous diabetes study…

This study follows people who previously took part in type 1 diabetes trials to see how long their bodies continue to produce insulin. Researchers will also look at how immune system changes relate to insulin production. The goal is to gather information that could lead to better…

This study is looking for the genes that cause certain immune system problems. Researchers want to understand why some people get sick and others don't, even in the same family. Up to 5,000 people with immune disorders and their relatives will give blood or cheek cell samples for…

This study will analyze DNA from up to 20,000 people, including those with immune disorders and their relatives, to find genetic variants linked to conditions like atopy, autoimmunity, and primary immunodeficiency. Researchers will also study how best to return genetic results to…

Researchers want to understand how well people with diabetes in Reunion Island and mainland France can find, understand, and use health information. About 1,350 patients with type 1, type 2, or gestational diabetes who receive hospital care complete a one-time questionnaire calle…

This observational study will compare teens with celiac disease who follow a gluten-free diet strictly versus those who don't, along with healthy peers. Researchers will test walking while doing mental tasks, memory, attention, muscle strength, quality of life, and fatigue. The g…

Researchers at IRCCS San Raffaele are creating a registry of images and videos from endoscopic ultrasound procedures performed to investigate pancreatic diseases. The study will gather data from about 12,000 patients with conditions like pancreatitis, pancreatic cancer, and neuro…

This registry follows pregnant women who have taken mycophenolate, a drug used to prevent organ rejection and treat autoimmune diseases. Researchers will collect data on pregnancy complications and birth defects up to one year after birth. The goal is to better understand the dru…

This study investigates why women with type 1 diabetes (T1D) frequently develop polycystic ovary syndrome (PCOS), a condition of high androgen levels. Researchers will compare five groups of 12 participants each, including women with T1D and PCOS, women with T1D alone, men with T…

This study looks at whether a new tool helps young adults (ages 18-30) with type 1 diabetes and their doctors work together better to make care plans that fit daily life. Researchers will compare usual doctor visits with visits using the tool, and interview participants afterward…

This study is for adults aged 18 to 55 who were diagnosed with type 1 diabetes within the last 6 months. Researchers want to see how many of them carry a specific gene called HLA-DRB1*04:01. Participants will provide a blood sample or cheek swab for genetic testing. The goal is t…

Researchers at Texas A&M are testing whether a wearable device can measure insulin levels from sweat and skin fluid instead of blood. 32 healthy adults aged 18-30 or 50-90 will eat a standard meal and have their insulin tracked over time. The goal is to see if this noninvasive me…

This study tests whether structured toolkits—including staff education, referral plans, and billing guidance—can help pediatric diabetes clinics deliver a behavioral intervention called Diabetes Coaching to more families of teens with type 1 diabetes. Researchers will ask whether…

This study observes 60 people with stage 2 type 1 diabetes who received teplizumab as part of managed access programs. Researchers will review medical records to describe patient characteristics, monitoring practices, and how long it takes for diabetes to progress. The goal is to…

This study aims to understand why some people are more prone to fungal infections, especially from Candida yeast. Researchers will collect blood, saliva, urine, and tissue samples from people with immune disorders, their family members, and healthy volunteers. No treatment is giv…

This study looks at gut bacteria in young people (ages 11-18) with type 1 diabetes, comparing those who are lean to those who are overweight or obese. Researchers want to see if differences in the microbiome relate to diabetes control and beta cell health. They will also test whe…

This study follows 150 young people (ages 6-23) with autoimmune liver disease to see if MRI scans can predict how their condition will progress over the next decade. Participants will have MRI scans at the start and again at one and two years, while their clinical health is track…

This study is screening children and adolescents aged 1.5 to 18 years who have a parent or sibling with type 1 diabetes. Researchers will collect blood samples to look for early signs of the disease, such as specific autoantibodies, before symptoms appear. The goal is to identify…

This study creates a shared registry and learning network for children and young adults with autoimmune liver disease, including autoimmune hepatitis and primary sclerosing cholangitis. By collecting clinical data across multiple centers, the goal is to reduce treatment variation…

This study is testing whether MRI scans can accurately detect bile duct damage and liver scarring in young people aged 6 to 23 with autoimmune liver diseases like primary sclerosing cholangitis and autoimmune hepatitis. Researchers will compare MRI results with traditional liver …

This study is testing whether a continuous glucose monitor (CGM) can predict blood sugar problems in people who are at risk for type 1 diabetes but have no symptoms. Researchers will follow 75 people aged 5 to 39 who have diabetes-related autoantibodies. They will compare CGM dat…

This study is testing whether a mobile app called Fabla-diabetesMM, which lets people record audio diaries, is easy and helpful for older adults with type 1 or 2 diabetes who also have other health conditions. Thirty participants will use the app and answer questions about their …

This study looks at whether people with non-celiac wheat sensitivity (NCWS) have a higher chance of having fatty liver or liver scarring. Researchers will compare liver health in people with NCWS to those with irritable bowel syndrome, functional dyspepsia, and celiac disease. Th…

This pilot study is testing whether a real-time continuous glucose monitor (FreeStyle Libre 3) can reveal differences in blood sugar patterns between people with diabetes who have gastroparesis (delayed stomach emptying) and those without it. About 50 adults with type 1 or type 2…

This study aims to learn more about how celiac disease damages the gut and how it heals. Researchers will look at gut cells, bacteria, the immune system, and genetics in 220 adults. The goal is to better understand symptoms and improve care for people with celiac disease.

This observational study follows 1,000 pregnant people with type 1 diabetes who use either a commercial or an open-source automated insulin delivery (AID) system. Researchers aim to compare maternal and neonatal outcomes, blood sugar control, and emotional well-being between the …

This study screens children and adolescents aged 5 to 18 who have chronic conditions like congenital heart disease, inflammatory bowel disease, celiac disease, or rheumatic diseases for lipid metabolism disorders. Participants provide a blood sample and complete a questionnaire a…

This study looks at how different phases of the menstrual cycle affect blood glucose changes during exercise in women with type 1 diabetes who take oral contraceptives. Participants wear a continuous glucose monitor and complete a 45-minute aerobic exercise session during both th…

This study looks at how blood sugar levels affect immune cells (monocytes) and kidney cells in people with type 1 diabetes and early chronic kidney disease. Researchers will compare participants with better versus worse blood sugar control to see if certain immune cells become mo…

This study looks at how improving sleep regularity might help control blood sugar and reduce heart disease risk in adults with type 1 diabetes. Researchers will monitor 100 participants' sleep, blood sugar, and heart health markers. The goal is to understand the body clock's role…

This study looks at basic blood and clotting measures in children with type 1 diabetes compared to healthy children. Researchers want to see if diabetes causes changes in red blood cells or clotting that could lead to complications. The study involves children aged 1 month to 18 …

This study is measuring a protein called STIM1 on the surface of immune cells in 670 people with various autoimmune diseases. The goal is to find which diseases have high levels of this protein, which could help researchers develop new antibody-based treatments. Participants prov…

This study is looking for biological markers (biomarkers) in blood, saliva, and urine that signal damage to insulin-producing beta cells in the pancreas. Researchers will compare samples from people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers. The g…

This study is testing a new device that combines an insulin pump with a continuous glucose monitor in one unit for adults with type 1 diabetes. The goal is to see how insulin delivery near the sensor affects glucose readings and to gather data to improve the design. About 40 part…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study from Mayo Clinic looks at how one session of exercise changes breastmilk. Researchers will measure tiny particles called exosomes that carry messages between cells. They want to see if exercise boosts these particles in breastmilk, which might help prevent childhood ob…

This trial is studying a medical device that has not been approved by the U.S. FDA. The purpose and specific details are not publicly available. It likely involves a small group of participants to gather initial safety or effectiveness data.

This study will give 100 adults with diabetes a thermal camera that attaches to their smartphone to take daily pictures of their feet. The goal is to collect temperature data and see if hot spots can predict where foot ulcers might form. Participants will use the device at home f…

This observational study is gathering detailed metabolic data from 25 adults with insulin-dependent type 2 diabetes. After drinking a standard liquid meal, participants will have frequent blood tests to measure glucose, insulin, and other markers. They will also wear continuous g…

This study looks at how menstrual cycles and birth control pills impact blood sugar levels and exercise in women with type 1 diabetes. Researchers will monitor 150 women for three months using continuous glucose monitors and offer personalized insulin and diet adjustments. The go…

This study looks at how blood sugar changes day-to-day in people with ketosis-prone diabetes as they go into remission. Researchers will use this data to build a math model that describes the remission process. The study involves 12 African American adults with a BMI of 28 or hig…

This study looks at how accurate continuous glucose monitors (CGMs) are in children and young adults with type 1 diabetes when they have surgery. Researchers will compare CGM readings to standard blood glucose tests during the procedure. The goal is to see if these devices can be…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study looks at how social factors and health literacy affect the ability of people with diabetes to manage their own care. Researchers will survey 400 adults with type 1 or type 2 diabetes to understand these connections. The goal is to design better support programs that he…

This study looks at whether improving sleep and circadian timing can reduce heart disease risk in adolescents with type 1 diabetes who typically sleep less than 7 hours per night. Fifty teens will follow a one-month program that includes a longer sleep schedule, a low dose of mel…

This study looks at whether a genetic risk score can predict which people with newly diagnosed diabetes will eventually need insulin. Researchers will follow about 3,000 patients aged 14 to 50 for up to 3 years, tracking their C-peptide levels (a marker of insulin production) and…

This study is collecting blood samples from 1,160 people with and without type 1 diabetes to analyze the immune cells that mistakenly attack the pancreas. The goal is to better understand how these cells work, which could lead to improved treatments or prevention strategies in th…

This study looks at whether a substance in the blood called 1,5-anhydroglucitol can help measure how many insulin-making cells (beta cells) children with type 1 diabetes still have. Researchers will compare levels in 60 children with diabetes (newly diagnosed and long-term) to he…

This study aims to find out how many relatives of people with celiac disease have non-celiac wheat sensitivity (NCWS) or other gut issues like IBS. Participants will follow a strict wheat-free diet for 6 weeks and report their symptoms. The goal is to better understand the link b…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at whether exercising before breakfast (fasted) or after breakfast (fed) is better for people with type 1 diabetes. Over 12 weeks, 20 participants will do combined resistance and aerobic training three times a week. Researchers will track insulin doses and blood …

This study looks at how being overweight affects insulin sensitivity and heart-lung fitness in people with type 1 diabetes. Researchers will compare participants with and without diabetes, before and after a 15-week high-intensity interval training program. The goal is to underst…

This study is testing a new ultrasound method that uses tiny, safe bubbles to measure blood flow in the pancreas. The goal is to see if changes in blood flow can help detect type 1 diabetes early, before symptoms appear. Researchers will compare 50 healthy adults and people recen…

This study surveys up to 900 adults with type 1 diabetes who use a closed-loop insulin system for at least 4 months. The goal is to understand how satisfied they are with the special 'physical activity mode' designed to prevent low blood sugar during exercise. Participants fill o…

This study is collecting health information, lifestyle data, and biological samples from up to 100,000 adults to help researchers better understand diseases like lupus, celiac disease, and kidney disease. Participants provide data and samples through a direct-to-patient platform.…

This study is observing 55 adolescents with type 1 diabetes to understand the many factors that influence their physical activity, from personal motivation to school and community support. Participants will wear an activity tracker for a week and complete questionnaires about the…

This study looks at whether improving blood sugar control in people with type 1 diabetes can restore the normal function of HDL, or 'good' cholesterol. Researchers will compare 80 patients with poorly controlled diabetes who receive standard intensive therapy to 63 healthy people…

This study looks at how often children with celiac disease also have fatty liver disease, and whether a gluten-free diet helps. Researchers will review medical records of 91 children to track changes before and after starting the diet. The goal is to better understand the link be…

This study tests whether a machine learning program can detect lipohypertrophy—hidden lumps under the skin caused by insulin injections—using portable ultrasound. About 100 people with diabetes will first have their injection sites scanned. In a second phase, 40 people found to h…

This study is collecting small intestine tissue samples from 300 adults to better understand and diagnose celiac disease and other small-bowel conditions. Researchers will use advanced techniques like AI image analysis and genetic profiling to create more reliable diagnostic tool…

This early-stage trial tests a new insulin formula (U-500) given directly into the belly cavity in 25 adults with type 1 diabetes. Researchers want to see if it's safe, how fast it's absorbed, and how quickly it works compared to standard insulin shots. Participants will have the…

This study looks at how the immune system of children with celiac disease responds to tiny, controlled amounts of gluten. About 51 kids on a strict gluten-free diet will get either a placebo, a small dose (50 mg), or a larger dose (5 g) of gluten daily for three days. Researchers…

This study involves 40 people with non-celiac gluten/wheat sensitivity who are already on a gluten-free diet. Researchers will use a new urine test to detect gluten proteins, checking if participants accidentally eat gluten and whether that links to their symptoms. The goal is to…

This study is a large registry that will follow 20,000 people with type 1 diabetes across China. It aims to track changes in blood sugar, kidney function, heart health, and emotional well-being over many years. The goal is to better understand how the disease progresses and impro…

This study tests different ways to help teenagers and young adults with type 2 diabetes address social needs like food or housing. About 104 teens and their caregivers will try either tailored resource lists or a universal empowerment approach. The goal is to see which method is …

This study collects and freezes testicular tissue from boys and young men who are at risk of becoming infertile due to cancer, autoimmune disorders, or their treatments. The tissue is stored in a research bank, with the hope that future medical advances will allow it to be used t…

This study follows 500 infants who have a close family member with celiac disease. Researchers track their genes, diet, gut bacteria, and other factors from birth to see what leads to the disease. The goal is to find ways to predict or prevent celiac disease in children who are a…

This study looks at how people with celiac disease react to gluten in liquid form (a shake) versus solid form (a cookie). Thirty adults on a gluten-free diet will try both, in random order, with blood samples taken to measure immune markers and symptoms. The goal is to see if liq…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1000 volunteers. Researchers will use advanced technology to identify different disease types and find new targets for therapies. The goal is to pave the way for pe…

This study explores how certain immune cells (MAIT cells) and gut bacteria work together in children who either have type 1 diabetes, are at high genetic risk, or are healthy. Researchers will collect blood and gut samples from 180 children to understand these interactions. The g…

This study is looking at how certain genes affect the immune system and may increase the risk of developing type 1 diabetes. Researchers will collect blood samples from 2,800 people to study immune cells and genetic risk factors. The goal is to better understand why some people d…

This observational study will measure oxidative stress and antioxidant levels in 75 people with type 1 diabetes and 75 with LADA (a slow-progressing form of autoimmune diabetes). Researchers will collect blood samples and compare markers like d-ROMs, BAP, and HbA1c to see if oxid…

This study observes 160 cancer patients to understand why some develop liver injury from checkpoint inhibitor drugs. Researchers will track blood markers and genetic factors to identify who is at risk. No new treatment is tested; the goal is to improve diagnosis and monitoring.

This study follows people with type 1 diabetes who have had an islet transplant that later stopped working. Researchers want to learn how the body's immune system changes after the graft is lost. The goal is to gather information, not to test a new treatment.

This study looks at the gut bacteria of 3000 adults with chronic liver diseases like autoimmune hepatitis and fatty liver. Researchers want to find specific bacteria linked to each disease to better understand how the gut and liver interact. This is an observational study, not a …

This study compares a pre-recorded, on-demand webinar led by dietitians to traditional one-on-one appointments for people newly diagnosed with coeliac disease. Sixty adults will be split into two groups to see if the webinar is just as effective at teaching them how to follow a s…

This study looks at children aged 2-16 who are newly diagnosed with type 1 diabetes. It checks if those who also have diabetic ketoacidosis (a serious complication) show early signs of kidney or heart injury using special blood and urine tests. The goal is to better understand wh…

This study follows 36 people with type 1 diabetes who have received a pancreatic islet transplant. Researchers will use continuous glucose monitors to see if a measure called 'Time in Tight Range' can detect early loss of graft function. The goal is to find a simple way to spot p…

This study takes a small sample of skin, blood, or urine from people with diabetes and healthy volunteers. Scientists will turn those cells into stem cells and then into insulin-producing cells in the lab. The goal is to learn more about diabetes and pave the way for future cell-…

This study aims to understand the step-by-step process that causes type 1 diabetes by looking at genetics and environment. Researchers will follow families with a history of the disease, as well as healthy controls, for up to 10 years. Participants provide a blood sample, medical…

This study looks at how different types of exercise—walking and weight-lifting—affect blood sugar levels in post-menopausal women with type 1 diabetes. Twenty participants will wear a continuous glucose monitor and complete three sessions: one with aerobic exercise, one with resi…

This study is working to create a system that can identify people at high risk for type 1 diabetes. Researchers will follow 340 people, including patients with type 1 diabetes and their close relatives, for four years. They will collect blood, urine, and stool samples each year t…

This study aims to identify different subgroups among people with type 1 diabetes by analyzing their health data using artificial intelligence. Researchers will look at clinical records and glucose monitoring information from 800 adults. Participants do not need to do anything ex…

This study looks at how blood sugar levels change during the menstrual cycle in women with type 1 diabetes. Researchers will track 86 women in Canada using continuous glucose monitors, insulin data, ovulation kits, and activity trackers. The goal is to understand why insulin need…

This study looks at how type 1 diabetes affects the nerves that control the heart in children. Researchers will measure heart rate variability in 100 children with diabetes and compare them to healthy kids of the same age and sex. The goal is to find early signs of cardiac dysaut…

This study is testing whether it's practical to screen thousands of children for type 1 diabetes and celiac disease during their regular doctor visits. Researchers will enroll up to 33,000 children from birth to age 6 and follow them for about 5 years. The goal is to see if paren…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study looks at why people with diabetes have a higher risk of memory problems and dementia. Researchers will use brain scans and thinking tests to see if brain insulin resistance and damaged blood vessels play a role. About 150 adults aged 50-80 with type 1 or type 2 diabete…

This early study tests whether a natural protein called C-peptide can help the liver produce more sugar during insulin-induced low blood sugar in people with type 1 diabetes. Researchers will give C-peptide or a placebo to 38 volunteers and measure glucagon levels and liver sugar…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study aims to understand why people with type 1 diabetes have a higher risk of heart attacks and strokes. Researchers will compare fat and protein processing in 30 adults—some with type 1 diabetes and some healthy—using special tracer infusions and blood tests. The goal is t…

This study follows 600 adults with autoimmune atrophic gastritis, a condition where the immune system attacks the stomach lining, leading to nutrient deficiencies and increased cancer risk. Researchers aim to track how the disease progresses over time and identify factors that le…

This study tests whether a virtual education program called CGM Academy helps youth (ages 8-18) with type 1 diabetes improve their blood sugar control. Participants will receive an interactive workbook and four online group sessions with diabetes educators, while a comparison gro…

This observational study will use special PET scans to measure how much oxygen the heart and kidneys use in people with type 1 diabetes. Researchers want to see if a more intensive treatment plan (multifactorial intervention) lowers oxygen demand compared to standard care. Forty …

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at how sleep apnea (pauses in breathing during sleep) affects blood sugar levels in adults with type 1 diabetes. Researchers will track blood sugar patterns using continuous glucose monitors in 40 participants. The goal is to understand the link between sleep apn…

This study looks at how exercising in hot conditions (40°C) changes blood sugar levels in people with type 1 diabetes compared to a normal temperature (20°C). 38 adults who have had type 1 diabetes for over a year and exercise regularly will do 40 minutes of moderate exercise in …

This study looks at whether newer automated insulin delivery systems help people with type 1 diabetes have healthier eating behaviors. Researchers will survey over 100 youth and adults across Canada about their eating habits and blood sugar control. The goal is to understand if t…

This study looks at whether continuous glucose monitors (CGMs) can help seafarers who need insulin manage their diabetes while working at sea. Fifty insulin-dependent seafarers will wear a CGM for 12 months and track their glucose levels during work and rest. The goal is to see i…

This study looks at how reducing cholesterol levels affects blood cells and blood vessels in people with type 1 diabetes. Researchers will follow 125 participants for one to two months to measure changes in platelet activity, immune cell function, and blood vessel health. The goa…

This early-phase study looks at whether reducing high insulin levels (common in type 1 diabetes) with an SGLT2 inhibitor can improve heart and blood sugar health. Researchers will compare people with type 1 diabetes, those with a mild genetic diabetes (GCK-MODY), and healthy volu…

This study looks at babies diagnosed with type 1 diabetes before age 2, a rare and extreme form of the disease. Researchers want to understand what goes wrong in the immune system to cause such early onset. By studying these children and comparing them to others with diabetes and…

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and memory tests to see which factors—like insulin resistance or inflammation—are most linked to changes in brain stru…

This study looks at whether sexual activity raises the risk of low blood sugar (hypoglycemia) in adults with type 1 or type 2 diabetes who use insulin and continuous glucose monitors. Researchers will track 100 participants for 3 months, comparing glucose levels on days with and …

This study looks at whether the chemicals in your breath change throughout the day and if those changes are different for people with diabetes. Researchers will measure breath samples from 60 adults—some without diabetes, some with type 1, and some with type 2. The goal is to lea…

This study follows 550 people with stage 2 type 1 diabetes in the U.S. to see how teplizumab affects their quality of life, anxiety, and diabetes management. Some participants received teplizumab, others did not, and researchers compare their experiences over time. The goal is to…

This study aims to identify subgroups of people with diabetes who share similar patterns between their blood sugar levels and mental health. By using smartphone surveys and continuous glucose monitors, researchers will create 'digital twins'—virtual models that can predict how me…

This study aims to understand how insulin sensitivity and blood sugar levels change across menstrual cycles in women with type 1 diabetes. Researchers will track 350 women aged 18-40 who have regular periods and use automated insulin delivery systems. The goal is to identify patt…

This observational study at Turku University Hospital will use ultrasound radiomics to compare fetal liver texture between 60 pregnant women with type 1 diabetes and healthy controls. The goal is to see if this noninvasive method can detect signs of fetal hyperinsulinemia (high i…

This study looks at blood samples from 80 children (ages 2-17) recently diagnosed with type 1 diabetes and compares them to healthy children. Researchers want to understand how certain immune cells (called T cells) stop working properly, leading to the disease. The goal is to gat…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study aims to identify specific blood markers that can distinguish hepatitis caused by immune checkpoint inhibitors from other types of autoimmune hepatitis. Researchers will collect blood samples and liver tissue from 60 adults receiving immunotherapy. The goal is to improv…

This study looks at how well people with type 1 diabetes follow the Mediterranean diet after starting the Minimed 780G insulin pump, and whether that affects their blood sugar levels and insulin use. About 240 participants aged 7 and older will be observed for 12 months. The goal…

This study looks at how controlling blood sugar and using a GLP-1 drug (liraglutide) changes the way the pancreas works in people with type 1 or type 2 diabetes. Researchers will measure hormone levels before and after treatment. The goal is to understand how these treatments aff…

This study looks at how blood sugar levels change during exercise in healthy adults and those with type 1 diabetes. Participants will cycle after a standard breakfast, and their glucose will be tracked with a continuous monitor and finger-prick tests. The goal is to see if the bo…

This early-phase study is testing whether the antidepressant fluoxetine (Prozac) and/or the hormone DHEA can improve the body's ability to defend against low blood sugar in people with type 1 diabetes. About 60 adults will take the drugs or a placebo for 8 weeks, then undergo two…

This study examines whether using advanced automated insulin pumps soon after diagnosis can protect brain growth and thinking skills in children aged 5-7 with type 1 diabetes. Researchers will compare brain scans and cognitive tests over 18 months between children using standard …

This observational study is looking at how diet, gut bacteria, and genetics influence blood sugar spikes after meals in people with type 1 diabetes. Researchers will track 200 participants using continuous glucose monitors, food diaries, and stool samples. The goal is to find pat…

This study is looking at why the immune system attacks the gut in people with celiac disease and other immune-related gut disorders. Researchers will collect blood and tissue samples from 200 adults to study immune cells and genes. The goal is to better understand what goes wrong…

This study looks at whether entering fake carbohydrates into the MiniMed 780G insulin pump improves blood sugar control in children and teens with type 1 diabetes. Forty participants aged 7-18 will try two weeks with fake carbs and two weeks without, and their glucose levels will…

This study is looking at 3,500 adults with celiac disease, dermatitis herpetiformis (a related skin condition), and their healthy friends or family. Researchers want to find genetic and biological markers that explain why the disease looks different in different people. No treatm…

This study looks at why diabetes devices like insulin pumps and continuous glucose monitors can cause skin irritation, eczema, or fatty lumps. Researchers will use non-invasive tools to measure skin health in 150 people with type 1 diabetes. The goal is to find ways to prevent th…

This study looks at how the time of day (circadian rhythm) affects blood sugar levels during different types of exercise in teenagers with type 1 diabetes. Researchers will have 18 teens do continuous and intermittent exercise on a stationary bike at different times. They will tr…