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Could a common blood pressure drug help kids with type 1 diabetes keep making insulin?

NCT ID NCT07199946

Disease control Sponsor: Johnny Ludvigsson Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether verapamil, a drug used for high blood pressure, can help children aged 4 to 9 with newly diagnosed type 1 diabetes keep making some insulin. The trial has two parts: first, 6 children will take verapamil to check safety; then, 30 more children will be randomly assigned to get verapamil or a placebo for 12 months. Researchers will measure insulin production and blood sugar control over 24 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Verapamil (a blood pressure drug)
What this could lead to
If it works, this could help children with type 1 diabetes keep making some of their own insulin, reducing the amount of insulin they need to inject.
What could go wrong
This is an early phase I/II trial with only 36 children, so results are preliminary. Verapamil may not work as well in children as it did in adults, and there are risks like low blood pressure or heart issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

May 2030

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

4 to 9 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: • Informed consent given by patients and caregivers/parents * Type 1 diabetes according to the ADA classification within the previous 3 months at the time of screening * Age 4.00 -9.99 years at Diagnosis of Type 1 diabetes * Fasting C-peptide \>0.12 nmol/ml * Elevated levels of any diabetes-related antibody/ies (eg GADA, IAA, IA-2A, ZnT8A ) is/are present. Exclusion criteria: • Cardiac disease/problems, abnormal ECG, or history of abnormal blood pressure * Previous or current treatment with immunosuppressant therapy (although topical or inhaled steroids are accepted) * Continuous treatment with any inflammatory drug (sporadic treatment e.g. because of headache or in connection with fever a few days will be accepted) * Treatment with any oral or injected anti-diabetic medications other than insulin * A history of anaemia or significantly abnormal haematology results at screening * Participation in other clinical trials with a new chemical entity within the previous 3 months * Inability or unwillingness to comply with the provisions of this protocol * A significant illness other than diabetes within 2 weeks prior to first dosing. However treated celiac disease and hypothyroidism with adequate treatment will be accepted. * Deemed by the investigator not being able to follow instructions and/or follow the study protocol

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Type 1 diabetes

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Crown Princess Victoria Children´s Hospital, University Hospital

    RECRUITING

    Linköping, SE58185, Sweden

  • Pediatric Clinic , Ryhovs hospital

    NOT_YET_RECRUITING

    Jönköping, Sweden

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