TYPE 1 DIABETES

This study is testing whether using an artificial pancreas system can improve heart and blood vessel health in people with type 1 diabetes. The artificial pancreas is a wearable device that automatically manages blood sugar. Researchers will measure heart health markers in 40 adu…

This study is comparing two different approaches to managing blood sugar during labor for pregnant people with type 1 diabetes who use an insulin pump system. Researchers want to see if allowing blood sugar to be in a slightly higher, more permissive range (70-140 mg/dL) is just …

This study is testing a new support program for young adults with type 1 diabetes as they move from pediatric to adult healthcare. The program involves a nurse, psychologist, and case manager working together to help participants manage this challenging life transition. Researche…

This study is testing whether an oral drug called DFMO can help preserve the body's own insulin production in people recently diagnosed with type 1 diabetes. About 70 participants will take either DFMO or a placebo pill twice daily for six months to see if it reduces stress on in…

This study is testing if adding a GLP-1 drug (semaglutide) to an existing immunotherapy (teplizumab) can better manage early Type 1 diabetes. Researchers want to see if this combination helps control blood sugar after meals, improves how the body uses insulin, and supports blood …

This study is testing a new automated insulin delivery system, the Medtronic 780G, for adults who have type 1 diabetes and a related stomach condition called gastroparesis. The main goal is to see if this 'closed-loop' system can help people spend more time with their blood sugar…

This study is testing whether an oral medication called dimethyl fumarate can help protect the body's remaining insulin-producing cells in adults recently diagnosed with type 1 diabetes. For 24 weeks, 90 participants will take either the drug or a placebo pill, with researchers m…

This study is testing a new, intensive management program for people with Type 1 diabetes. It combines a dedicated care team, technology like insulin pumps and glucose monitors, education, and peer support. The goal is to see if this comprehensive approach helps people achieve be…

This study is testing the early feasibility of a new automated insulin delivery system for adults with Type 1 diabetes. A smartphone app will use data from a glucose sensor to automatically control an insulin pump. The goal is to see if this 'hybrid closed-loop' system works reli…

This study follows 1,000 people with early-stage Type 1 diabetes for up to 10 years after they receive teplizumab treatment in regular medical care. Researchers want to see how well the treatment delays the need for insulin and affects patients' quality of life over time. The stu…

This study is testing whether a program that pays teenagers money helps them better manage their type 1 diabetes. About 96 teens who currently struggle with daily tasks like checking blood sugar and taking insulin will be randomly assigned to either receive cash rewards for meeti…

This study is testing a new smartphone tool called Tia Bete that uses artificial intelligence to help people with type 1 diabetes. The AI helps count carbohydrates in meals and suggests insulin doses in real-time. Researchers want to see if using this tool for six months improves…

This study is observing how well the Omnipod 5 automated insulin delivery system works for people with type 1 diabetes in their everyday lives. It will follow 304 adults and children in France for one year to see how the system affects blood sugar control, quality of life, and sa…

This study is testing if a drug called verapamil, commonly used for blood pressure, can help preserve the body's remaining insulin-making cells in children recently diagnosed with type 1 diabetes. It will involve 36 children aged 4 to 10 years old. The goal is to see if this safe…

This study is testing an investigational cell therapy called VX-880 in people who have type 1 diabetes and have already received a kidney transplant. The main goal is to see if the treatment can help participants stop needing insulin injections. Participants must already be on st…

This study is testing whether a combination of three existing drugs can help preserve the body's remaining insulin-producing cells in children and young adults recently diagnosed with type 1 diabetes. The goal is to slow disease progression and reduce dependence on injected insul…

This study is testing whether connecting young adults with type 1 diabetes to a community health navigator helps them resolve social needs like housing or food insecurity. Researchers will compare 100 participants who receive this support to those who continue with usual care. Th…

This study is testing a new, self-learning insulin calculator app for teens and young adults with type 1 diabetes. The goal is to see if this tool, used with an automated insulin pump, is safe and helps people spend more time in a healthy blood sugar range. Participants will try …

This early-stage study is testing an experimental cell therapy called CELZ-201 in adults recently diagnosed with Type 1 Diabetes. The main goal is to see if the treatment is safe and if it can help the body produce its own insulin, potentially reducing the need for insulin inject…

This study is testing a 3-month mobile health program called the Discovery Program to see if it helps teens and young adults (ages 13-21) better manage their type 1 diabetes. The program provides personalized messages and clinician support to help with daily challenges. Researche…

This study is testing if a two-step treatment can help young people recently diagnosed with type 1 diabetes. First, some will receive a low-dose immune therapy (ATG) or a placebo. Then, all will have the option to take a blood pressure drug (verapamil) for a second year. The main…

This study is testing whether transferring healthy gut bacteria from a donor (called a washed microbiota transplant) can help people with Type 1 Diabetes. Researchers will enroll 50 participants to see if the treatment safely improves blood sugar control and reduces the amount of…

This study is testing whether a 12-week high-fiber diet can help protect the body's ability to produce insulin in children recently diagnosed with type 1 diabetes. Researchers will compare children who follow the special diet to those who receive usual care. They will measure ins…

This early-stage study is testing the safety and performance of a new, concentrated insulin formulation. It involves 25 adults with Type 1 Diabetes. Researchers will inject the insulin into the abdomen and carefully monitor how the body absorbs it and controls blood sugar over 12…

This study is testing whether lowering cholesterol with specific medications can improve blood vessel health and reduce inflammation in people with Type 1 Diabetes. Researchers will follow 125 participants for 1-2 months while they receive weekly injections and daily pills to low…

This study is testing whether a new automated insulin delivery system called AIDANET is safe and practical for children aged 6-13 with type 1 diabetes. The system uses a smartphone, a special insulin pump, and a continuous glucose monitor to try to keep blood sugar levels in a he…

This study is testing whether daily omega-3 fatty acid supplements can help maintain healthy blood vessels in the eyes of people with type 1 diabetes. Researchers will enroll 80 adults with type 1 diabetes who will take omega-3 supplements for one year while having regular eye ex…

This is the first human study testing a new treatment called OPF-310, which involves transplanting specially encapsulated insulin-producing cells from pigs into people with unstable type 1 diabetes. The goal is to see if these transplanted cells can safely help control blood suga…

This study is testing whether colchicine, an anti-inflammatory medication, can help people with type 1 diabetes use insulin more effectively. Researchers are enrolling 26 adults who have type 1 diabetes with signs of ongoing inflammation and reduced insulin sensitivity. Participa…

This study is testing a new automated insulin delivery system called AIDANET for adults with type 1 diabetes. It compares how well the system works in different modes, including a 'full closed-loop' mode that doesn't require meal announcements. The goal is to see if this new syst…

This study is testing if a wearable continuous glucose monitor (CGM) is better than the standard finger-prick method for managing blood sugar in people with Type 1 diabetes while they are in the hospital. Researchers want to see if the CGM helps keep blood sugar in a safe range m…

This early-stage clinical trial is testing an investigational drug called CNP-103 in people aged 12-35 who were recently diagnosed with type 1 diabetes. The main goal is to see if the treatment is safe and if it can help protect the body's remaining insulin-producing cells. Resea…

This study is testing whether an online training and peer support platform called 'Support' helps adults with type 1 diabetes manage their daily care. Researchers are comparing two groups: one where doctors recommend the platform as part of regular care, and another where people …

This study is testing whether a sleep coaching program can help teenagers with type 1 diabetes. Researchers want to see if improving sleep duration and quality leads to better blood sugar control and sharper thinking skills. The trial will involve 150 teens and their caregivers, …

This study is testing whether a specially designed online game can help children with type 1 diabetes. Researchers will see if playing the game for 9 weeks improves blood sugar control, confidence in managing the condition, and overall quality of life. The study involves 58 child…

This study aims to monitor the long-term safety of TZIELD, a drug already approved to delay the onset of insulin-dependent type 1 diabetes in people at high risk. It will follow 200 patients in the US who either receive TZIELD or are not treated with it, tracking their health ove…

This study is testing an investigational drug called SAB-142 to see if it can slow down the progression of type 1 diabetes in people recently diagnosed. Researchers want to find out if the drug can help the body preserve its own ability to make insulin, potentially reducing the n…

This study is testing whether repeat doses of the BCG vaccine, typically used against tuberculosis, can help children recently diagnosed with type 1 diabetes. Researchers want to see if the vaccine can improve long-term blood sugar control and help the body preserve its own insul…

This study is testing a special camera that uses artificial intelligence (AI) to check for eye damage from diabetes in children and young adults. The goal is to see if using this quick, in-office camera can help more young people from underserved communities get screened. Researc…

This study is testing a new, easier way to screen for early signs of type 1 diabetes in children. Researchers are comparing a simple finger-prick test done at home on blotting paper to the standard, more complex blood tests drawn from a vein. The goal is to validate this simpler …

This study is testing how accurate a new at-home finger-prick glucose test is compared to the standard blood draw done in a clinic. It involves 60 people who are at risk for or have recently been diagnosed with type 1 diabetes. The goal is to see if this easier, home-based method…

This study is testing whether a telehealth program called REAL-Fam can help rural families better manage their child's type 1 diabetes. Researchers want to see if this 12-week virtual support program improves family quality of life, reduces stress, and helps stabilize children's …

This study is testing whether a specific type of video-delivered talk therapy, combined with reviewing continuous glucose monitor data, can help young adults with type 1 diabetes feel less anxious and depressed and improve their blood sugar control. Researchers will compare this …

This study is testing if online cognitive behavioral therapy (CBT) can help reduce the emotional distress and worry that often comes with managing type 1 diabetes. Researchers will compare the therapy, combined with a continuous glucose monitor, to using the monitor alone in 93 a…

This study is testing two different talk therapy programs to help people with type 1 diabetes who also struggle with eating disorders like binge eating or restricting insulin for weight control. Researchers want to see if these therapies can improve blood sugar levels, reduce eat…

This study is testing a new program called R2D2 that aims to help families of children with type 1 diabetes manage the emotional stress of the disease. The program screens for 'diabetes distress' in both children and parents and provides support to reduce it, with the goal of imp…

This study aims to understand if newer automated insulin delivery systems affect eating behaviors and food-related stress in people with type 1 diabetes. Researchers will observe 106 participants in Canada, comparing those using automated systems to those using injections or stan…

This study aims to find early signs of type 1 diabetes in children and teenagers who have a close family member with the condition. Researchers will screen 3,500 participants over 13 months to see how many develop these early markers. The goal is to better understand who is at ri…

This study aims to understand why blood sugar levels after meals vary so much between people with Type 1 Diabetes. Researchers will observe 200 participants to see how their diet, gut bacteria, and body chemistry interact. The goal is to gather knowledge that could lead to more p…

This study aims to understand why people with type 1 diabetes have a higher risk of heart attacks and strokes. Researchers will compare how the bodies of 30 adults with and without type 1 diabetes process certain fats and proteins in the blood. The goal is to gather knowledge abo…

This study aims to understand how the drug teplizumab is used in real-world medical practice for people with early-stage type 1 diabetes. Researchers will review the medical records of about 60 people who have already received this treatment. The goal is to learn about the patien…

This is the first study in humans for a new drug called MTX-101. Researchers want to understand its safety, how long it stays in the body, and how it affects immune cells. The study will involve healthy adults and people with type 1 diabetes to gather initial data.

This study aims to understand how the timing of exercise affects blood sugar in teens with type 1 diabetes. Researchers will compare morning versus afternoon workouts, and continuous moderate exercise versus intense interval sessions. The goal is to gather knowledge to help manag…

This study aims to understand why people with type 1 diabetes lose their natural defense against dangerously low blood sugar. Researchers will test a substance that blocks a specific hormone (GLP-1) in 12 participants to see if it helps restore a normal protective response. The g…

This study aims to understand how the immune system goes wrong in children recently diagnosed with type 1 diabetes. Researchers will compare blood samples from 80 children, half with diabetes and half without, focusing on specific immune cells. The goal is to gather knowledge tha…

This large study aims to screen 33,000 children for early warning signs of type 1 diabetes and celiac disease during their regular doctor visits. Researchers want to see if routine screening can help identify children at risk before they get seriously ill. Children who test posit…

This study aims to understand how the drug teplizumab affects the daily lives and health of people with early-stage type 1 diabetes. It will follow 550 people in the U.S. for five years, comparing those who received the drug to those who did not. The main goal is to measure chang…

This study aims to understand how a common diabetes drug (liraglutide) and blood sugar control affect a specific hormone (GLP-1) produced inside the pancreas. Researchers will compare these effects in 60 people with Type 1 and Type 2 diabetes who use insulin. The goal is to learn…

This study aims to understand if a natural protein called C-peptide can help the liver make more sugar during episodes of low blood sugar (hypoglycemia). Researchers will compare people with type 1 diabetes to healthy volunteers to see if giving C-peptide during a controlled low …

This study aims to understand how different types of exercise affect blood sugar levels in post-menopausal women with type 1 diabetes. Researchers will monitor 20 participants' blood sugar during and after rest, treadmill walking, and weight-lifting sessions. The goal is to gathe…