TYPE 1 DIABETES

This study is testing whether a 12-week high-fiber diet can help protect the beta-cells (the cells that make insulin) in children aged 6 to 12 who were recently diagnosed with type 1 diabetes. The goal is to see if this dietary change can slow the loss of insulin production. Part…

This study looks at whether adding a GLP-1 drug (like semaglutide) to teplizumab helps control blood sugar and protect the heart in people with early stage type 1 diabetes. About 24 participants aged 12–50 will have meal tests and ultrasounds to measure how their bodies respond. …

This study tests a treatment called VX-880 in 10 people who have both type 1 diabetes and a kidney transplant. The goal is to see if it can help them stop taking insulin while keeping their blood sugar under control. Participants will continue taking lifelong anti-rejection drugs…

This study tests a smart insulin delivery algorithm called AIDANET in adults with type 1 diabetes. It compares three modes: fully automatic, hybrid (with some user input), and a mix. The goal is to see which mode keeps blood sugar in a healthy range more consistently. Participant…

This study is testing whether a specially designed digital game can help children aged 8 to 13 with type 1 diabetes improve their blood sugar control, confidence in managing their condition, and overall quality of life. The game is based on a health model and aims to make learnin…

This study looks at how well the Omnipod 5 automated insulin delivery system works for people with type 1 diabetes in their daily lives. About 304 participants aged 2 and older will use the system for the first time. Researchers will measure blood sugar control, quality of life, …

This study tests a 3-month program called Discovery Diabetes for teens and young adults (ages 13-21) with type 1 diabetes. Participants get personalized text messages and extra support from their clinic team. Researchers will check if this helps lower blood sugar levels (HbA1c) a…

This study is testing a treatment called washed microbiota transplantation (WMT), which is a purified fecal transplant, to see if it can help people with type 1 diabetes manage their blood sugar better. The goal is to reduce the amount of insulin they need each day and increase t…

This study tests a two-step treatment for adolescents and young adults recently diagnosed with type 1 diabetes. First, participants receive a low dose of anti-thymocyte globulin (ATG) to calm the immune system, then verapamil to reduce stress on insulin-making cells. The goal is …

This study tests whether an online training and support platform can help adults with type 1 diabetes better manage their blood sugar and well-being. About 322 participants will use the platform for 12 months, either through their usual clinic or on their own. Researchers will tr…

This study tests whether the Medtronic 780G automated insulin delivery system can safely improve blood sugar control in adults with type 1 diabetes who also have gastroparesis (stomach paralysis). About 34 participants will use the system for a period, and researchers will measur…

This study tests whether giving children (ages 8 to under 18) with newly diagnosed type 1 diabetes repeated doses of the BCG vaccine (normally used for tuberculosis) can improve blood sugar control and reduce insulin needs. The goal is to see if the vaccine can calm the immune at…

This study tests whether colchicine, an anti-inflammatory drug, can improve how well the body responds to insulin in people with type 1 diabetes who have low-grade inflammation. Researchers will measure insulin sensitivity using a special test. The trial involves 26 adults and co…

This study tests a new medicine called CNP-103 in people aged 12 to 35 who were diagnosed with stage 3 type 1 diabetes within the last 6 months. The goal is to see if the drug is safe and can help control the disease. Participants will receive either CNP-103 or a placebo over 90 …

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells (the cells that make insulin) placed inside tiny capsules. The goal is to see if transplanting these cells is safe and can help adults with unstable type 1 diabetes who still have dangerous lo…

This study tests whether a low dose of anti-thymocyte globulin (ATG) followed by either adalimumab or verapamil can help young people (ages 9 to under 21) with newly diagnosed type 1 diabetes keep making their own insulin for longer. About 120 participants will be randomly assign…

This study tests a new medicine called SAB-142 to see if it can slow the progression of type 1 diabetes in people recently diagnosed. About 159 participants aged 5 to 40 will receive either the drug or a placebo. The main goal is to check safety and whether the drug helps the bod…

This study looks at whether allowing slightly higher blood sugar levels (70-140 mg/dL) during labor is as safe as the current strict approach (70-110 mg/dL) for pregnant women with type 1 diabetes. About 44 women will be randomly assigned to one of the two groups. The main goal i…

This study tests a program that helps kids aged 10-13 with type 1 diabetes and their parents find and build on the child's strengths. The goal is to improve blood sugar control, daily diabetes care, and quality of life. The program involves youth, parents, and diabetes care provi…

This study is tracking how well the Omnipod 5 insulin pump works in real life for 2,200 children and adults with type 1 diabetes. Researchers will monitor blood sugar control, severe low blood sugar events, and quality of life over 12 months. Participants use the device as prescr…

This study tests a new care approach for 80 young adults with type 1 diabetes who are moving from pediatric to adult healthcare. The program includes a nurse educator, psychologist, and transition navigator working together to provide support. The goal is to see if this team-base…

This study tests a program called T1CARE that connects young adults with type 1 diabetes to a community health navigator who helps them resolve social needs like food, housing, or transportation. About 100 participants will be randomly assigned to receive the navigator support ri…

This study looks at whether using an artificial pancreas (a system that automatically manages blood sugar) can also improve heart health in people with type 1 diabetes. Researchers will measure blood sugar control and markers of inflammation and blood vessel function in 40 adults…

This study tests whether verapamil, a drug used for high blood pressure, can help children aged 4 to 10 with recent-onset type 1 diabetes preserve their remaining insulin production. The trial has two parts: first, a small safety check, then a larger blinded comparison with place…

This study follows 120 Israeli children and teens with type 1 diabetes who are starting to use the Medtronic 780G insulin pump system. Researchers want to see if the system helps them keep their blood sugar in a healthy range more often and improves their quality of life. Partici…

This early-stage study tests a new treatment called CELZ-201 for people recently diagnosed with type 1 diabetes. The treatment is given through an artery and aims to see if it is safe and can help control the disease. The study involves 18 adults aged 18-35 who were diagnosed wit…

This study compares a continuous glucose monitor (Dexcom G7) to standard finger-stick blood sugar tests in 100 hospitalized adults with poorly controlled type 1 diabetes. The goal is to see which method keeps blood sugar in a healthy range (70-180 mg/dL) longer and reduces danger…

This study tests whether a comprehensive management program, which includes a care team, technology, education, and peer support, can help people with type 1 diabetes better control their blood sugar and improve their mental health. The study will involve 400 participants across …

This study follows 1,000 people with early-stage (Stage 2) Type 1 Diabetes who received teplizumab during routine care. Researchers want to see how long the drug delays progression to full-blown (Stage 3) diabetes and how it affects quality of life. Participants are observed for …

This study looks at whether changing how and when people with type 1 diabetes eat carbohydrates can help control blood sugar levels. Researchers will compare two different eating patterns in 80 adults over a period of time. The goal is to find a simple dietary approach that impro…

This study follows 200 people with stage 2 type 1 diabetes who take TZIELD to delay the disease. Researchers will watch for side effects, serious events, and effects during pregnancy over many years. The goal is to understand the long-term safety of this treatment in real-world u…

This study tests an artificial intelligence tool called Tia Bete that helps people with type 1 diabetes count carbohydrates and figure out the right insulin dose. About 50 children and adults will use the tool for six months to see if it improves blood sugar control and quality o…

This early study tests a new smartphone-based system that automatically adjusts insulin delivery for adults with type 1 diabetes. Six participants will use the system for a short time under close supervision. The goal is to see if the technology works reliably and safely before l…

This study tests whether offering financial rewards can help teenagers with type 1 diabetes improve their blood sugar management. About 96 adolescents who use a continuous glucose monitor will either receive usual care or get paid for meeting daily goals. Researchers will compare…

This study tests a new system called AIDANET that uses a smartphone app to control an insulin pump and continuous glucose monitor in children aged 6-13 with type 1 diabetes. The goal is to see if it is safe and works as well as their usual diabetes care. About 36 children will pa…

This study tests whether the drug DFMO can help people with newly diagnosed type 1 diabetes keep making some of their own insulin. About 81 participants will take either DFMO or a placebo pill twice a day for 6 months. Researchers will measure insulin production and check for sid…

This study tests whether dimethyl fumarate, a drug already used for multiple sclerosis, can protect the pancreas cells that make insulin in people newly diagnosed with type 1 diabetes. About 90 adults will take either the drug or a placebo twice daily for 24 weeks, and researcher…

This study tests whether taking a prebiotic fiber supplement for 6 months can help people with type 1 diabetes better control their blood sugar and reduce dangerous lows. The researchers will also look at how the supplement affects gut bacteria and gut health. The study involves …

This study looks at how well the Omnipod 5 automated insulin delivery system works in daily life for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar in a healthy range and…

This early-stage study tests a new drug called MTX-101 in healthy adults and people with type 1 diabetes. The main goal is to check for side effects and see how the drug moves through the body. Researchers will also look at how MTX-101 affects immune cells. The study involves up …

This study tests whether a special camera with artificial intelligence can help screen more young people with diabetes for a condition called diabetic retinopathy, which can lead to vision loss. The study will include 500 children and teens with type 1, type 2, or cystic fibrosis…

This study is testing whether a fingerstick glucose test done at home can accurately screen for type 1 diabetes, compared to the standard clinic-based test. Researchers will enroll 60 people who are at risk for or recently diagnosed with type 1 diabetes. The goal is to see if the…

This study checks if a combined test on a simple blotting paper (like a dried blood spot) can accurately detect type 1 diabetes in children. Researchers will compare results from the blotting paper test with standard blood tests in 106 children newly diagnosed with diabetes. If s…

This study tests whether intensive diet and activity advice given to parents of infants at high genetic risk for type 1 diabetes can protect the cells that make insulin. About 1,244 babies will be enrolled by 4 months old and followed until age 6. Half the families get extra coun…

This study is testing a serious video game designed to help teenagers aged 12 to 16 develop emotional skills and improve their quality of life. The game includes special modules for teens with type 1 diabetes, asthma, food allergies, or allergic rhinitis. Researchers will measure…

This study tests a program called R2D2 that helps families of children with type 1 diabetes cope with diabetes-related stress. The program screens for distress and offers treatment to improve blood sugar control and quality of life. About 180 children aged 8-12 and their parents …

This study tests whether a tablet called sotagliflozin can improve quality of life for people with type 1 diabetes who also have heart failure. About 320 adults in the UK will take either the drug or a placebo daily for 4 months. The goal is to see if the drug reduces symptoms li…

This study tests a behavioral program to help teenagers with type 1 diabetes sleep longer and better. Researchers will see if improved sleep helps with blood sugar levels and thinking skills like focus and memory. About 150 teens aged 11-17 who currently get too little sleep and …

This study tests whether online cognitive behavioral therapy (CBT) combined with a continuous glucose monitor (CGM) can reduce diabetes distress in adults with type 1 diabetes. About 93 participants will be randomly assigned to receive either CBT plus CGM or CGM alone for 6 month…

This study tests a telemedicine-delivered cognitive behavioral therapy program designed to reduce anxiety and depression in young adults with type 1 diabetes. About 94 participants will receive the therapy along with continuous glucose monitor review. The goal is to see if this a…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help people with type 1 diabetes who also have eating disorders. About 235 people aged 16 to 50 will be assigned to ACT, supportive diabetes counseling, or a waitlist. Researchers w…

This study looks at how food, gut bacteria, and genetics work together to affect blood sugar after meals in people with type 1 diabetes. Researchers will track 200 participants' meals, sleep, and blood sugar using a continuous glucose monitor. No treatment is given; the goal is t…

This early-phase study looks at how a natural protein called C-peptide might help people with type 1 diabetes recover faster from low blood sugar (hypoglycemia). Researchers will measure hormone levels and liver sugar production in 38 adults. The goal is to understand if C-peptid…

This study is testing whether analyzing the chemicals in a child's breath can help doctors understand and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to see if breath patter…

This study looks at whether automated insulin delivery (AID) systems help people with type 1 diabetes have healthier eating behaviors and less stress around food. Researchers will survey 106 youth and adults across Canada about their eating habits and blood sugar control. The goa…

This study tests a telehealth program called REAL-Fam designed to help rural families manage a child's type 1 diabetes. About 16 families will take part, with some receiving the full 12-session program and others attending only 3 general meetings. The main goal is to see if the p…

This study is gathering information from medical records of about 60 people with stage 2 type 1 diabetes who received the drug teplizumab. The goal is to learn more about the patients' health history, how doctors monitor them, and how quickly their diabetes progresses. This is an…

This study aims to understand why people with type 1 diabetes have a higher risk of heart attacks and strokes. Researchers will compare fat and protein metabolism in 30 adults with and without type 1 diabetes using special tracer infusions. The goal is to uncover biological clues…

This early-stage study is testing a new concentrated insulin (U-500) given directly into the belly area in 25 adults with Type 1 Diabetes. The goal is to see if it is safe and how quickly the body absorbs and uses it. Participants will have their blood sugar kept steady for 12 ho…

This study aims to learn more about the immune cells that attack the pancreas in type 1 diabetes. Researchers will compare blood samples from 1,160 people with and without diabetes to find patterns in these cells. No treatments or medications are given—the goal is simply to gathe…

This study aims to understand how certain genes linked to type 1 diabetes affect the immune system. Researchers will follow 2,800 people over time, taking blood samples to see who develops diabetes. No treatment is given; the goal is to learn how the disease starts.

This study looks at how controlling blood sugar and using a GLP-1 drug (liraglutide) changes the way special cells in the pancreas work in people with type 1 or type 2 diabetes. Researchers will measure hormone levels during fasting and high blood sugar. The goal is to understand…

This study looks at how reducing cholesterol levels changes blood clotting cells, immune cells, and blood vessel health in people with type 1 diabetes. Researchers will follow 125 participants for one to two months, taking blood samples to measure these effects. The goal is to be…

This study looks at how being overweight and having type 1 diabetes affects heart and muscle fitness. Researchers will test 60 adults to see if insulin resistance lowers exercise capacity, and whether a high-intensity interval training program can improve it. The goal is to bette…

This study looks at blood samples from 80 children recently diagnosed with type 1 diabetes and healthy controls to understand why the immune system attacks the pancreas. Researchers will compare two types of immune cells—regulatory and conventional T cells—to find what goes wrong…

This study looks at how the time of day (circadian rhythm) affects blood sugar control during different types of exercise in teens aged 10-16 with type 1 diabetes. Researchers will compare blood sugar levels during morning and afternoon workouts, including both steady and intense…

This study looks at whether improving blood sugar control in people with type 1 diabetes can restore the function of their 'good' HDL cholesterol to normal levels. Researchers will compare 80 patients with poorly controlled diabetes who receive intensified therapy to 63 healthy v…

This study is testing whether it's possible to screen all children for type 1 diabetes and celiac disease during regular doctor visits. Researchers will enroll up to 33,000 children from birth to age 6 at Sanford Health clinics. The goal is to see if parents will agree to screeni…

This study aims to understand how different types of exercise—aerobic (like walking) and resistance (like weight lifting)—affect blood sugar levels in post-menopausal women with type 1 diabetes. Twenty participants will wear a continuous glucose monitor and complete three separat…

This study follows 550 people with stage 2 type 1 diabetes in the U.S. to see how their quality of life, anxiety, and diabetes management change over time. It compares those who received the drug teplizumab with those who did not. The goal is to understand the real-world benefits…

This study screens children and teenagers (ages 1.5 to 18) who have a parent or sibling with type 1 diabetes. The goal is to find early signs of the disease, like specific antibodies in the blood, before any symptoms appear. Participants will have two visits over 13 months to che…