Digestive system disorder

Researchers are comparing two ways of performing robotic surgery to remove stomach cancer: a single-port approach and a standard multi-port approach. The trial enrolls 212 adults with stomach cancer that can be removed with distal gastrectomy. The main question is whether the sin…

This phase 3 trial tests whether adding sintilimab, an immunotherapy drug, to chemotherapy before surgery helps people with early-stage oral squamous cell carcinoma. Participants are adults aged 18 to 75 with cT2N0M0 oral cancer that can be removed by surgery. Half receive sintil…

This trial is testing an experimental therapy called IOV-5001, which uses a patient's own immune cells (tumor-infiltrating lymphocytes) to attack cancer. The study involves adults with advanced solid tumors, including non-small cell lung cancer, triple-negative breast cancer, col…

This study tests whether liver transplantation can extend survival for adults with colorectal cancer that has spread only to the liver and cannot be removed or destroyed by local treatments. About 260 participants aged 18 to 65 will receive a new liver from a deceased or living d…

Researchers are testing whether a combination of chemotherapy (mFOLFOX6) plus two immunotherapy drugs, suvemcitug and enlonstobart, can shrink high-risk mid-rectal cancer enough to safely skip pelvic radiation before surgery. The trial enrolls 52 adults with locally advanced rect…

Researchers are testing whether adding a PD-1 antibody and pegylated interferon to standard antiviral pills can help people with chronic hepatitis B lose the hepatitis B surface antigen. The trial enrolls adults whose virus is already suppressed by nucleos(t)ide analogues and who…

Researchers are testing a combination treatment for people with recurrent cryptoglandular perianal fistula, a painful tunnel that keeps coming back after surgery. The study enrolls 25 adults who have had at least two failed fistula operations and have a seton drain in place for a…

This phase 1 trial tests whether injecting RGB-5088 islet cells under the abdominal muscle can safely help people with type 2 diabetes. The study enrolls 10 adults aged 18 to 65 who have had diabetes for at least 5 years and currently use insulin. Researchers will monitor safety …

This study tests whether giving the immunotherapy drug dostarlimab for a longer period can completely eliminate tumors in people with a specific genetic type of rectal cancer. Participants have stage II or III rectal cancer that is mismatch repair deficient (dMMR) or microsatelli…

Researchers test whether a short course of targeted radiation followed by the immunotherapy drug adebrelimab and NALIRIFOX chemotherapy can shrink locally advanced pancreatic cancer enough to allow surgery. The trial enrolls 36 adults with previously untreated pancreatic ductal a…

Researchers are testing whether a liver-sparing form of chemoembolization, called partial TACE, can boost the anti-tumor effects of the drug lenvatinib in people with liver cancer that cannot be removed by surgery. The trial enrolls about 40 adults with hepatocellular carcinoma w…

Researchers are studying whether patients can safely leave the hospital within 48 hours after minimally invasive colorectal surgery. The trial follows 97 adults having elective laparoscopic or robotic surgery for benign or malignant disease. It checks how many meet predefined cli…

This study looks at the safety and effectiveness of Rybelsus, a pill for type 2 diabetes, in everyday medical practice in Korea. About 600 adults will take the medicine as their doctor prescribes, and researchers will track side effects and blood sugar control for 26 weeks. The g…

Researchers are testing whether seltoplasmid, a gene therapy injected into the calf muscle, can improve outcomes for people with type 2 diabetes who have poor blood flow to the foot and a non-healing ulcer. All participants first undergo a standard procedure to restore blood flow…

This early-stage trial tests an oral capsule containing a genetically modified probiotic yeast designed to neutralize toxins produced by C. diff bacteria. The study first evaluates safety in healthy adults, then in people at risk for recurrent C. diff infection. Participants take…

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

This trial tests whether a drug called carfilzomib, given directly to the liver through an implanted pump, is safe for people whose colon, adrenal, or bile duct cancer has spread to the liver and persists after prior pump therapy. Participants receive weekly infusions of the drug…

This study tests whether a continuous glucose monitor (CGM) is better than standard finger-prick tests for managing blood sugar in 100 pregnant women with gestational diabetes. Participants will either wear a small sensor or continue finger-pricking. The goal is to see if CGM is …

Researchers are testing a chemotherapy combination built around albumin-bound paclitaxel (II) for people with pancreatic cancer. The study has three groups: one for advanced cancer that cannot be removed by surgery, one for cancer that may be removable and receives treatment befo…

Researchers are testing whether combining an experimental dual immunotherapy drug called QL1706 with standard chemotherapy (docetaxel, oxaliplatin and S-1) before surgery can help patients with locally advanced gastric or gastroesophageal junction cancer. The study enrolls 34 adu…

Researchers are testing a new immunotherapy called Lm-LLO-TT in adults with advanced pancreatic ductal adenocarcinoma that has already been treated with chemotherapy. Lm-LLO-TT uses a weakened form of Listeria bacteria engineered to carry a tetanus toxoid antigen, aiming to spark…

Researchers at the University of Oklahoma are testing whether adding pentamidine, an antiparasitic drug, to standard modified FOLFIRINOX chemotherapy is safe and helps shrink tumors in people with advanced or metastatic pancreatic cancer. Up to 30 adults with confirmed locally ad…

This study compares four different sequences of biologic drugs (infliximab, filgotinib, ustekinumab, and vedolizumab) in 240 adults with moderate to severe ulcerative colitis. The goal is to see which order of treatments works best to achieve and maintain remission without steroi…

Researchers are testing whether adding CT-guided thermal ablation of liver or lung metastases to standard systemic therapy improves tumor response in people with nasopharyngeal carcinoma. The trial enrolls 138 adults whose primary tumor was cured but who later developed up to fiv…

Researchers are testing whether adding two oral drugs, avutometinib and defactinib, to standard chemotherapy (mFOLFIRINOX) is safe and can slow or shrink pancreatic ductal adenocarcinoma. The trial has two parts: one for people whose cancer has spread, and one for people whose ca…

Researchers are running a Phase I trial of HEC-921, an experimental drug given by intravenous infusion, in adults with advanced malignant solid tumors. The study first gives HEC-921 alone to find the highest dose people can tolerate, then tests it in combination with oxaliplatin,…

Acute uncomplicated diverticulitis is often treated with antibiotics, but evidence suggests they are not always needed. This study evaluates whether a standardized treatment approach based on clinical findings, lab results, other health conditions, and CT scans can reduce unneces…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

Researchers are testing an experimental injectable drug called ALK-N001 in adults with advanced gastrointestinal tumors, including esophageal and colorectal cancers that have worsened after standard treatment. The phase II trial gives the drug intravenously every two weeks at one…

Researchers are testing whether measuring specific proteins in tumors can help match patients with advanced pancreatic or breast cancer to antibody-drug conjugates that are more likely to work for them. The trial enrolls 225 adults whose cancer has progressed after prior treatmen…

Choledochal cyst is a congenital bile duct problem that surgeons treat by removing the cyst and rebuilding the bile duct with a Roux-en-Y hepaticojejunostomy, often using a surgical robot. Surgeons usually leave an abdominal drainage tube in place afterward, but better robot prec…

Researchers are studying whether adding local treatments such as ablation, radiotherapy, or transarterial therapy to the drug combination atezolizumab plus bevacizumab helps certain patients with unresectable hepatocellular carcinoma live longer. The study uses medical records an…

Researchers test whether coconut oil pulling or a moringa mouthwash can reduce gingivitis in children with diabetes, compared with chlorhexidine. Thirty children aged 6 to 12 with mild to moderate gingivitis use one of the three rinses. The team measures gum inflammation and leve…

Researchers are testing whether a new combination of two antibodies, JS207 and JS007, works better than the standard first-line treatment of toripalimab plus bevacizumab for advanced liver cancer. The trial enrolls about 560 adults with liver cancer that cannot be removed by surg…

Researchers are testing whether giving sacituzumab tirumotecan plus toripalimab before surgery helps people with locally advanced esophageal squamous cell carcinoma. Participants receive three cycles of the combination, then undergo standard surgery to remove the tumor. The main …

This phase II trial tests whether the experimental drug BL-B01D1, given with or without a PD-1 antibody, can improve tumor shrinkage in people with high-risk locally advanced nasopharyngeal carcinoma, a type of throat cancer. Participants also receive standard chemotherapy drugs …

This trial is testing whether a combination of drugs—inavolisib plus fulvestrant, with or without palbociclib—is safe for people with a specific type of advanced breast cancer (HR+, HER2-negative) that has a PIK3CA mutation, and who also have type 2 diabetes. The main focus is on…

Researchers are testing whether a combination of four experimental oral drugs, AD-233A, AD-233B, AD-233C and AD-233D, can improve blood sugar control in adults with type 2 diabetes. The Phase III trial enrolls about 354 participants and compares the drug combination against an ac…

Researchers are running a first-in-human study of MGC030, an antibody-drug conjugate, in people with advanced solid tumors that have come back or stopped responding to standard treatment. The trial includes participants with urothelial, colorectal, gastric, gastroesophageal, esop…

Researchers at Assiut University Children Hospital are studying whether a specially prepared medical milk formula called Modulen IBD can bring Crohn's disease into remission and keep it there in children and teenagers. About 40 young patients with mild to moderate active Crohn's …

Researchers are tracking how long adults with moderate to severe Crohn's disease or ulcerative colitis keep taking guselkumab, a biologic drug, in routine care. The study follows about 400 people who start the treatment and records when they stop. It also checks whether early imp…

Researchers are running a phase 1 trial to find out how safe and tolerable ATTO-1091 is in healthy adults and in people with ulcerative colitis. The study also measures how long the drug stays in the body. About 96 participants will receive either ATTO-1091 or a placebo, visit th…

This trial tests whether a combination of two investigational drugs (QL-1706) plus chemotherapy and bevacizumab, with or without radiation, can shrink or eliminate tumors in people with locally advanced rectal cancer before surgery. The goal is to see if this neoadjuvant approach…

This study looks at whether propranolol, a drug often used for high blood pressure, helps or harms people with advanced cirrhosis (severe liver scarring). The trial will include 466 adults with a MELD score over 9, meaning their liver disease is fairly advanced. Researchers will …

This phase III trial is testing whether adding an experimental drug called BL-B01D1 to standard maintenance therapy with a PD-1 antibody can help people with recurrent or metastatic nasopharyngeal carcinoma live longer without their cancer progressing. Participants first receive …

Researchers are testing whether nitazoxanide, an antiparasitic drug with anti-inflammatory properties, can help people with mild-to-moderate ulcerative colitis when added to their usual treatment. The trial enrolls adults aged 18 to 65 with active disease and stable therapy. Over…

Researchers are testing whether adding serplulimab, an immunotherapy, to standard CAPOX chemotherapy and bevacizumab can shrink locally advanced colorectal tumors before surgery. The study enrolls about 85 adults with locally advanced rectal adenocarcinoma. The main goal is to se…

Researchers are testing whether a probiotic yeast, Saccharomyces boulardii, works as well as the antibiotic rifaximin for adults with small intestinal bacterial overgrowth (SIBO) who have bloating and diarrhea. The trial enrolls 222 people aged 18 to 70 with a positive breath tes…

Researchers are testing whether giving chemotherapy before surgery helps people with pancreatic cancer that can be removed. The trial compares two drug combinations, gemcitabine plus nab-paclitaxel and FOLFIRINOX, in adults with resectable pancreatic adenocarcinoma. After treatme…

This study tests an experimental drug called WGI-0301 combined with lenvatinib in 80 people with advanced liver cancer who have already tried one treatment. The goal is to see if the combination is safe, tolerable, and shrinks tumors. It is an open-label, non-placebo trial across…

This study will enroll 20 severely obese adults scheduled for metabolic surgery. Half will use a continuous glucose monitor (CGM) and half will use standard finger-stick testing to track blood sugar. Researchers want to see if the CGM leads to steadier blood sugar levels and fewe…

The HARVEST study is testing whether eating a special low-glycemic, high-protein rice instead of regular white rice can improve blood sugar control in people with prediabetes or type 2 diabetes. Over 16 weeks, 225 adults in Singapore will replace their usual rice with one of thre…

This trial tests whether eating almonds as an evening snack improves overnight blood sugar in pregnant women with gestational diabetes. About 156 women will either eat 43 grams of whole almonds daily or a nut-free snack for 28 days. Researchers will measure blood sugar levels ove…

Researchers are testing whether combining trastuzumab with retlirafusp alfa helps people with HER2-positive gastric or gastroesophageal junction cancer that has worsened after standard first-line treatment. The trial enrolls about 35 adults whose tumors test HER2 2+ or 3+. Partic…

Many people live with heart disease, kidney disease, and type 2 diabetes at the same time, but care often focuses on each condition separately. This trial tests a primary care model that brings these conditions together under one coordinated plan. Primary care centers receive tra…

This early-stage trial is testing a new drug called ACT500 in 24 people who have both fatty liver disease and chronic hepatitis B. The main goal is to check the drug's safety and how the body processes it at different doses. Participants will take ACT500 or a placebo daily, and r…

This trial investigates whether adding a once-weekly injection of tirzepatide to standard diabetes pills can improve blood sugar control and promote weight loss in obese adults with type 2 diabetes. Over six months, researchers will compare changes in HbA1c and body weight betwee…

Researchers are testing whether a digital behavioral therapy app, added to standard diabetes care, can improve blood sugar control and lower the risk of liver fibrosis in adults with type 2 diabetes. The trial enrolls 180 adults with type 2 diabetes who are at low to moderate ris…

Researchers are testing a combination of three drugs in adults with advanced gastric cancer that has grown after one standard chemotherapy regimen and whose tumors carry the PD-L1 protein. The drugs are irinotecan liposome (a chemotherapy wrapped in fat particles), fruquintinib (…

Researchers test whether giving mFOLFOXIRI plus bevacizumab before surgery can shrink locally advanced rectal cancer enough to avoid removing the rectum. Adults with stage II or III rectal cancer receive six cycles of the drug combination. Depending on how well the tumor responds…

Researchers are testing an experimental drug called BL-M08D1 in adults with nasopharyngeal carcinoma that has come back or spread, as well as other solid tumors. Participants receive the drug by intravenous infusion every three weeks. The trial aims to find a safe dose for furthe…

Researchers are testing whether adding an experimental drug called ONO-4578 to nivolumab and chemotherapy helps people with advanced or metastatic gastric cancer, esophagogastric junction cancer, or esophageal adenocarcinoma. The trial enrolls about 600 adults whose tumors are HE…

This early-stage study tests a new oral drug called ACT500 in 24 adults with fatty liver disease (MASLD). The main goal is to check safety and how the drug moves through the body. Participants take one pill daily in different dose groups. The study does not aim to cure the diseas…

Researchers are testing how safely and comfortably people with type 2 diabetes can switch from semaglutide to CagriSema, a weekly injection that combines cagrilintide and semaglutide. About 210 adults who have taken a stable dose of branded semaglutide for at least three months w…

Pancreatic and other biliopancreatic cancers often block the bile duct, causing jaundice and serious infections. Doctors use endoscopic procedures to place stents that restore bile flow, but several techniques exist and it is unclear which works best. This study follows 300 patie…

Researchers test whether adding retlirafusp alfa, an experimental immunotherapy, to standard targeted drugs and chemotherapy can shrink colorectal cancer that has spread to the liver enough to allow surgery. The trial enrolls about 80 adults with initially unresectable liver meta…

This phase 2 trial tests the safety of belzutifan, a daily oral tablet, in adolescents with rare solid tumors that cannot be surgically removed or have spread. The study includes three tumor types: pheochromocytoma/paraganglioma (PPGL), wild-type gastrointestinal stromal tumors (…

Researchers are testing whether combining retlirafusp alfa, famitinib, and AG chemotherapy (nab-paclitaxel plus gemcitabine) can slow cancer growth in people with unresectable pancreatic cancer. The trial enrolls about 88 adults with locally advanced or metastatic pancreatic duct…

Researchers are testing whether adding targeted radiation plus the immunotherapy drug cadonilimab to standard second-line chemotherapy helps adults with colorectal cancer that has spread only to the peritoneum. The trial enrolls about 198 participants and randomly assigns them to…

This study tests whether a smartphone app that shows real-time blood sugar and activity data can help adolescents and young adults with type 2 diabetes improve their glucose control. Participants use a continuous glucose monitor and Fitbit, and some receive prompts to reflect on …

Researchers are studying whether microwave ablation, helped by a saline injection that separates the liver tumor from the diaphragm, is safe and effective for hepatocellular carcinoma. They compare this approach with surgical resection in patients whose single tumor is 5 cm or sm…

Researchers are testing UrDiaCare, an Urdu-language app that gives diabetes self-management education and support through WhatsApp or Android. The trial includes 406 adults aged 30 to 70 in Pakistan who have type 2 diabetes and higher-than-recommended blood sugar levels. Particip…

Researchers are testing whether adding olomorasib, an experimental drug that targets the KRAS G12C mutation, to cetuximab and standard chemotherapy (mFOLFOX6) helps people with advanced colorectal cancer that cannot be removed by surgery or has spread. The trial enrolls about 50 …

Researchers are testing a wafer called EF-009 that surgeons place directly onto pancreatic tumors during a minimally invasive operation. The trial enrolls adults with borderline resectable or unresectable pancreatic cancer, meaning tumors that surgery may or may not be able to re…

This phase 2 trial tests whether an oral supplement called N-acetylglucosamine (GlcNAc) can safely help control Crohn's disease in the ileum or ileocolon. Forty adults with stable Crohn's will receive either GlcNAc or a placebo for 6 weeks, then switch after a washout period. The…

Researchers at El Katib Hospital are testing a procedure called endoscopic band ligation on the upper part of the small intestine in people with type 2 diabetes. The goal is to reshape the duodenal lining so it may release more gut hormones that help control blood sugar. Ten adul…

This study tests whether a blood test that detects HPV DNA can help doctors choose the right treatment for people with HPV-positive oropharyngeal cancer. About 116 participants with stage I to III cancer will receive either the immunotherapy drug pembrolizumab (Keytruda) or stand…

Researchers are testing whether adding rimegepant to standard chemoimmunotherapy before surgery helps shrink oral or oropharyngeal squamous cell carcinoma more effectively. The trial enrolls adults with primary or recurrent disease who are scheduled for surgery. Participants rece…

This study looks at people with atrial fibrillation (an irregular heartbeat) who have already had a successful mitral valve repair. It compares two approaches: catheter ablation (a procedure to fix the heart's electrical signals) versus standard medical care. The goal is to see i…

This trial tests whether adding diloxanide furoate to the standard antibiotic metronidazole improves recovery from amoebic liver abscess, a serious infection of the liver caused by a parasite. About 220 adults with a new diagnosis will receive either the added drug or a placebo, …

Researchers are testing a new drug called TS-104 in adults with advanced solid tumors, including lung, head and neck, ovarian, endometrial, esophageal, and gastric cancers. TS-104 is a peptide drug conjugate: it uses a targeting peptide to carry the chemotherapy drug MMAE directl…

This study tests whether oral vancomycin, an antibiotic, can help children aged 6-15 with inflammatory bowel disease (IBD), especially types linked to liver problems. About 140 kids will either get vancomycin plus standard care or standard care alone for up to a year. Researchers…

Researchers are testing whether a multidisciplinary care model helps people with type 2 diabetes and chronic kidney disease start and adjust five classes of heart and kidney protective medicines within four months. The trial enrolls about 570 adults at high or very high risk of k…

People newly diagnosed with breast, colorectal, lung, or prostate cancer often also manage other long-term conditions and take multiple medications. This pilot study tests whether a pharmacist-led medication review plus the Medisafe mobile app helps them stick to those regimens. …

Perforated peptic ulcers need urgent surgery. The usual minimally invasive repair uses a piece of the omentum to patch the hole, but that tissue is sometimes scarred or unavailable. This trial randomly assigns adults with small perforations to either the standard omental patch or…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

Researchers are testing an investigational drug called SKB571 in adults with advanced or metastatic pancreatic cancer. The trial aims to see how well the drug shrinks tumors and how safe it is. Participants receive SKB571 every three weeks, and doctors track their response using …

Researchers are testing whether an experimental immunotherapy called ZG005, combined with bevacizumab, works better than the standard combination of sintilimab and bevacizumab for people with advanced hepatocellular carcinoma who have not yet received systemic treatment. The tria…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

Researchers are observing how tirzepatide works in routine care for adults in Pakistan who have obesity, prediabetes, or type 2 diabetes. The study follows 330 people starting the medicine as part of their normal treatment at ten diabetes and endocrinology centres. Doctors decide…

Researchers are testing a drug called 3D185 in people with advanced or metastatic cholangiocarcinoma, a type of bile duct cancer, whose tumors have changes in the FGFR2 gene. All participants have already received at least one other systemic cancer treatment that stopped working.…

This phase 1 trial tests an investigational drug called DEM301 in adults with advanced colorectal cancer that has progressed after standard treatments. DEM301 is an antibody-drug conjugate, a type of therapy designed to deliver a toxic agent directly to cancer cells. The study ai…

This trial tests whether the GX-01S continuous glucose monitoring system helps adults with type 1 or type 2 diabetes improve their blood sugar control. Participants wear the sensor for about 4.5 months, with the first 15 days blinded to establish a baseline, then full access to r…

Researchers are testing whether a diet low in serine and glycine, combined with chemotherapy, immunotherapy, and radiotherapy, improves outcomes for people with locally advanced rectal cancer. The trial enrolls 140 adults aged 18 to 80 with stage cT3, cT4, or node-positive rectal…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

Researchers in Oman are testing whether a structured education program that combines diabetes and oral health advice can improve blood sugar control and gum health in adults with type 2 diabetes. The trial enrolls 290 adults aged 35 and older who have had type 2 diabetes for at l…

This trial tests whether an experimental drug called HRS-7172, when combined with other antitumor therapies, can safely shrink or control advanced pancreatic cancer that has RAS mutations or amplifications. The study includes adults aged 18 to 70 with locally advanced or metastat…

This trial tests whether adding N-acetylcysteine (NAC), an antioxidant, to standard care improves early response in people with liver cirrhosis who develop spontaneous bacterial peritonitis (SBP), a serious infection of the abdominal fluid. Researchers will give 60 adults either …

This phase II trial is testing whether a 16-hour fast before each dose of the immunotherapy drug serplulimab, combined with chemotherapy, can improve outcomes for people with a common type of locally advanced rectal cancer. The approach aims to boost the immune system's ability t…

This trial tests whether individualized nursing care can help adults with diabetes feel more confident and capable in managing their condition. Participants receive structured, personalized sessions that include education, goal-setting, and self-monitoring guidance. The study mea…

This early-phase trial tests an oral drug called R01 in people with advanced squamous cell lung cancer, gastric cancer, or esophageal cancer that has progressed after standard treatment. The study aims to find the safest dose and check whether R01 can shrink tumors. Participants …

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This trial tests whether an automated insulin delivery system, the DEKA TWIIST pump with Tidepool Loop software, can safely manage glucose levels in pregnant people with type 1 diabetes. The system adjusts insulin automatically and can be set to pregnancy-specific glucose targets…

This trial tests whether adding nitazoxanide, a drug used for parasitic infections, to standard antibiotics can improve outcomes for people with liver cirrhosis who develop spontaneous bacterial peritonitis, a severe infection of the abdominal fluid. Researchers will compare two …

This trial tests whether two moderate low-carbohydrate diets, one higher in protein and one higher in fat, improve blood sugar, blood fats, and weight more than a standard diet. Adults with type 2 diabetes, high triglycerides, and overweight or obesity will follow one of the thre…

This study tests two common methods for calculating mealtime insulin doses in hospitalized adults with type 2 diabetes. One method, carbohydrate counting, adjusts the insulin dose based on the grams of carbs a patient actually eats. The other uses a fixed dose that changes only w…

This phase 2 trial tests whether giving two immunotherapy drugs, pembrolizumab and porustobart, before surgery can shrink tumors in adults with a common type of colon cancer called MSS (microsatellite stable) that has not spread. Participants receive the drugs through a vein, wit…

This early-stage trial tests an experimental drug called STRO-006 in adults with advanced solid tumors, including head and neck, lung, esophageal, gastric, colorectal, endometrial, bladder, and breast cancers that have not responded to standard treatments. The study has three par…

This phase 2 trial tests whether adding the investigational drug becotatug vedotin to pucotenlimab and capecitabine before standard chemoradiotherapy can improve outcomes for people with locally advanced squamous cell carcinoma of the anal canal. Participants first receive two cy…

This trial tests an experimental oral drug called DES-1357 in adults with metastatic colorectal cancer that has specific genetic features (dMMR or MSI-H). The study runs in three parts: first, to find a safe dose; second, to check tolerability and early signs of tumor shrinkage; …

This early-stage trial tests an investigational drug called ABBV-253 in adults with advanced solid tumors, including lung, colorectal, and pancreatic cancers. The study aims to find safe doses and see whether the drug can shrink tumors. Participants receive the drug by infusion, …

This study tests a drug called sacituzumab tirumotecan in 20 people with advanced anal or rectal cancer that has spread or cannot be removed and has not responded to other treatments. The goal is to see if the drug can shrink tumors and how safe it is. Participants will receive t…

This trial tests an experimental drug called SGC001 in people who are likely to develop severe acute pancreatitis, a painful inflammation of the pancreas that can lead to organ failure. Participants receive either SGC001 or a placebo as a single intravenous infusion alongside sta…

This phase III trial tests an experimental drug called YL201 against standard chemotherapy in people with metastatic pancreatic cancer that has progressed after gemcitabine-based treatment. YL201 is designed to deliver a toxin directly to cancer cells that carry a specific marker…

This pilot study tests whether an herbal supplement called Biocidin REMOVE can clear small intestinal bacterial overgrowth (SIBO) in adults with irritable bowel syndrome (IBS). SIBO involves an overgrowth of bacteria in the small intestine, which can worsen IBS symptoms. About 40…

This trial tests whether pembrolizumab, an immunotherapy drug, is safe when combined with chemotherapy or chemoradiotherapy for people in India with advanced gastric or gastroesophageal junction cancer, advanced biliary tract cancer, or high-risk locally advanced cervical cancer.…

This trial tests whether combining two targeted therapies, with or without chemotherapy, can improve outcomes for people with resectable stomach or gastroesophageal junction cancer. Participants receive the treatment before and after surgery to remove the tumor. The main goal is …

This study tests a 12-week digital program led by a nurse to help young adults (ages 18-45) with type 2 diabetes better manage their condition. Participants use a web or mobile app for education, goal-setting, and direct messaging with a nurse. The goal is to see if this approach…

This trial tests whether adding an experimental immunotherapy (SHR-1701) and a targeted drug (apatinib) to standard chemotherapy (gemcitabine and nab-paclitaxel) can help people with advanced pancreatic cancer. The study enrolls adults aged 18 to 75 who have not yet received trea…

This trial tests whether a coordinated care pathway, involving oncologists, geriatricians, pharmacists, and pharmacologists, can reduce severe side effects in adults over 70 with certain cancers who are starting oral therapy. Participants receive extra monitoring, including blood…

This phase 2 trial tests whether choosing treatment based on the genetic changes in a person's pancreatic cancer works better than standard chemotherapy. Adults with advanced pancreatic cancer that has progressed after first-line treatment may join if their tumor has a genetic ch…

This trial tests whether adding an experimental drug called TQA3605 to standard antiviral therapy helps more adults with chronic hepatitis B reach undetectable virus levels. About 930 participants who have been on antiviral treatment for at least a year will receive either TQA360…

This trial tests whether a special cooling tube placed near the pancreas can help people with acute pancreatitis recover faster. Participants are randomly assigned to receive either standard care alone or standard care plus the cooling device for up to three days. The study measu…

This trial tests whether an experimental drug called LBL-024, when combined with standard treatments like bevacizumab, oxaliplatin, capecitabine, or fruquintinib, can safely shrink tumors in people with metastatic colorectal cancer. The study includes adults aged 18 to 75 who hav…

This early-phase trial tests two immunotherapy drugs (ivonescimab and ADG126) alone or with chemotherapy in 30 adults with advanced or metastatic MSS colorectal cancer, a type that doesn't respond well to standard immunotherapy. The main goal is to find safe doses and check for s…

This trial tests whether preparing the bowel before fistula laser closure surgery helps the wound heal better. Anal fistulas are abnormal tunnels that can form near the anus, and laser closure is a technique to seal them while sparing the muscle. Researchers will compare two grou…

This trial tests whether fluoxetine, a common antidepressant, can improve bowel function in adults with chronic constipation that has not responded to standard laxatives. Participants also show features of somatic symptom disorder, where emotional distress appears as physical sym…

This trial is testing whether adding a non-invasive ultrasound treatment called histotripsy to the immunotherapy drug durvalumab can strengthen the body's immune response against advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer. Histotripsy uses focused sound …

This study tests whether peer support specialists—people who have been through liver transplant for alcohol-related disease themselves—can help others in the same situation stay sober and attend medical appointments. About 95 participants will meet regularly with a peer supporter…

This early-phase trial tests whether adding vitamin C to standard steroid treatment helps people with gastrointestinal graft-versus-host disease (GVHD), a serious complication after a donor stem cell transplant. About 35 participants aged 5 and older will receive vitamin C plus s…

This study tests a combination of two immunotherapy drugs (tremelimumab and durvalumab) plus chemotherapy (gemcitabine and cisplatin) in people with a rare, advanced liver cancer called combined hepatocellular-cholangiocarcinoma that cannot be removed by surgery or has spread. Ab…

This trial tests whether giving a combination of immunotherapy (sintilimab) and two chemotherapy drugs (paclitaxel polymeric micelles and cisplatin) before surgery can help people with a certain type of esophageal cancer. The treatment aims to shrink tumors and improve the chance…

This study looks at whether a preventive endoscopic procedure (sphincterotomy) can lower the risk of future bile duct problems in frail patients who cannot have their gallbladder removed after a bout of pancreatitis caused by gallstones. About 92 adults will be randomly assigned …

This early study tests if injecting a person's own stem cells into the upper gut is safe and feasible for treating type 2 diabetes. The stem cells are taken from belly fat and processed before being injected during a scope procedure. Only 15 people will take part, and the main go…

This trial tests a cell therapy called DC-CTL, made from a patient's own immune cells, combined with standard anti-tumor treatment. The goal is to see if this approach is safe and may help control solid tumors such as colorectal, esophageal, lung, liver, and breast cancer. About …

This trial tests whether adding Bacillus probiotic spores to standard treatment can help people with Crohn's disease or ulcerative colitis. Researchers will give 150 adults either a placebo or one of two probiotic formulas for 30 days, alongside their usual care. The goal is to s…

This trial compares two surgical approaches for people with pancreatic cancer in the left side of the pancreas. One method removes the spleen along with the tumor, which is standard practice. The other preserves the spleen, potentially reducing complications and avoiding lifelong…

This trial tests whether a minimally invasive laser procedure can close low perianal fistulas as effectively as traditional open surgery. Adults with a primary low perianal fistula are randomly assigned to receive either laser closure or open fistulectomy. Researchers track heali…

This trial tests whether mazdutide, a weekly injection that targets GLP-1 and glucagon receptors, can safely reduce portal pressure in overweight adults with compensated cirrhosis and clinically significant portal hypertension. Participants receive 16 weeks of mazdutide, with the…

This phase 1 trial tests the safety and tolerability of LMT503, an oral drug intended for inflammatory bowel disease, in healthy adults aged 18 to 65. Participants receive either LMT503 or a placebo in single or multiple ascending doses, with some also checking how food affects t…

This phase II trial tests whether adding retlirafusp alfa to standard chemotherapy and bevacizumab can shrink tumors in people with advanced RAS-mutated colorectal cancer that has spread to the liver. The study enrolls 46 adults who have not had prior systemic treatment and whose…

This trial looks at people who have both periodontitis (gum disease around natural teeth) and peri-implantitis (inflammation around dental implants). Researchers will measure three proteins in the fluid around teeth and implants before and after routine non-surgical therapy, whic…

This trial tests whether continuous glucose monitoring (CGM) can improve blood sugar control and reduce complications in hospitalized adults with type 2 diabetes, compared to standard finger-prick testing. Participants are randomly assigned to either CGM with a sensor-guided insu…

This 8-week pilot trial tests whether eating at least 56 grams of almonds daily can raise blood levels of vitamin E and improve overall diet quality in adults taking GLP-1 medications like semaglutide or tirzepatide for obesity or type 2 diabetes. Participants are split into two …

This trial tests whether giving hydrocortisone during and right after pancreatic surgery can lower the risk of a postoperative pancreatic fistula, a serious leak of digestive fluids. About 20 adults with pancreatic, duodenal, or bile duct cancer will be randomly assigned to recei…

This trial tests whether adding trastuzumab rezetecan, a targeted antibody-drug, to standard chemotherapy and bevacizumab can safely control advanced colorectal cancer that carries the HER2 marker. Researchers will enroll 48 people with HER2-positive, unresectable or metastatic c…

This early-stage trial tests an experimental medicine called BI 3822971 in adults with advanced or metastatic solid cancers, such as lung, head and neck, breast, esophageal, bladder, vulvar, or cervical cancer, who have no standard treatment options left. The goal is to find out …

This Phase 2 trial tests an investigational once-weekly injection called SYH2069 in adults with type 2 diabetes whose blood sugar is not well controlled by diet, exercise, or metformin alone. Researchers compare several doses of SYH2069 against a placebo and an existing diabetes …

This trial tests whether infusions of stem cells from human umbilical cords can help people with primary biliary cholangitis, a liver disease that damages bile ducts. It is for patients who have not responded well to the standard medicine, ursodeoxycholic acid. The study first ch…

This trial tests whether an experimental drug called ATG-022 can slow the growth of advanced stomach or gastroesophageal junction cancer better than standard chemotherapy. The study enrolls adults whose tumors show a specific marker called CLDN18.2 and who have already tried at l…

This phase 2 trial tests a combination of two drugs, XL-092 and pembrolizumab (Keytruda), given before surgery to people with a type of oral cancer that is HPV-negative and can be removed. The goal is to see if the drugs can shrink or eliminate the tumor before the operation. Abo…

This observational study tracks how long patients with moderate-to-severe Crohn's disease or ulcerative colitis continue taking guselkumab, a biologic treatment, in everyday clinical practice. Researchers will measure time until treatment discontinuation and early responses like …

This trial tests whether a single oral dose of ondansetron, a drug that curbs vomiting, can help children with cholera keep down oral rehydration solution (ORS). About 120 children aged 6 months to 17 years with suspected or confirmed cholera and active vomiting will receive eith…

This trial tests whether a specially designed smartphone app can improve self-management and blood sugar control in adults with type 2 diabetes. Participants use the app for daily tracking, video health lessons, and guidance from a team of doctors, nurses, dietitians, and pharmac…

This phase II trial tests a new treatment approach for people with locally advanced nasopharyngeal carcinoma, a type of head and neck cancer. The regimen avoids platinum-based chemotherapy, using a combination of gemcitabine, camrelizumab, endostar, and low-dose radiotherapy befo…

This trial is testing whether a new oral drug called HRS-2329, which blocks multiple RAS proteins, can shrink tumors or slow disease when combined with other anti-cancer therapies. It is enrolling adults with advanced pancreatic cancer that has RAS mutations or amplifications and…

This phase II trial is testing whether an experimental oral medication, DA-302168S, can help people with type 2 diabetes control their blood sugar. The study will compare the drug against a placebo in about 272 adults who are already taking metformin. Researchers will measure cha…

This trial is testing whether CRB-701, a targeted chemotherapy that delivers a potent drug directly to cancer cells, can shrink tumors and extend life in people with recurrent or metastatic oropharyngeal (throat or tonsil) cancer. Participants will have already tried platinum-bas…

This trial tests whether a dietary fiber called resistant potato starch can reduce the amount of drug-resistant bacteria living in the gut. The study enrolls Veterans who carry these bacteria without symptoms, and half will take the starch daily while the other half takes a place…

This trial tests whether a daily supplement of calcium-HMB plus vitamin D3 can help adults aged 65 to 85 with type 2 diabetes keep their muscle mass and metabolism while starting semaglutide, a common weight-loss and diabetes medication. Participants take the supplement or a plac…

This pilot study tests whether a surgeon located at a different hospital can safely perform parts of robotic prostate or colorectal cancer surgery using the Toumai robotic system. The local surgical team remains with the patient and can take over control at any moment. Researcher…

This trial tests whether draining the gallbladder through an endoscope works better than the standard percutaneous approach for people with acute cholecystitis who are too sick for surgery. Researchers will randomly assign 212 participants to receive either endoscopic ultrasound-…

This trial tests whether adding daily oral zinc to standard targeted therapy and immunotherapy helps people with advanced liver cancer. About 60 participants will be randomly assigned to receive the standard treatment alone or with either 20 mg or 30 mg of zinc each day. The main…

This pilot trial tests a personalized AI platform called PIPE-AI, enhanced by DiabetesGPT, to see if it can help adults with prediabetes or type 2 diabetes improve their self-management and knowledge. Participants are randomly assigned to either use the AI platform for three mont…

This Phase 2 trial is testing whether rilvegostomig, an experimental immunotherapy that blocks two immune-suppressing pathways (PD-1 and TIGIT), can produce a stronger immune response against advanced gastric cancer than the standard single-target drug pembrolizumab. About 50 peo…

This study tests whether hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — can help heal perianal fistulas in people with Crohn's disease who haven't improved with standard treatments. Participants will either receive HBOT or continue with conven…

This early-stage trial is testing whether combining two chemotherapy drugs—liposomal irinotecan and cisplatin—can safely shrink or control advanced solid tumors that have not responded to standard treatments. The study will enroll about 44 adults aged 20 to 85 with various types …

This trial tests whether using a dye to identify and remove only the sentinel lymph nodes (the first nodes cancer might spread to) during esophageal cancer surgery is as effective as removing all nearby lymph nodes. The study includes 200 adults with early-stage esophageal squamo…

This phase 3 trial is testing whether the experimental drug zanzalintinib, alone or combined with an immunotherapy (pembrolizumab plus berahyaluronidase alfa), can improve disease-free survival in people with stage II or III colorectal cancer who have molecular residual disease (…

This study looks at how zanidatamab, a targeted drug for HER2-positive gastroesophageal cancer, is used in real-world clinical practice. Researchers will track about 300 adults with advanced or metastatic disease who are starting zanidatamab as their first treatment, recording pa…

This trial is testing whether an investigational drug called AZD6234, given as a weekly injection, can help adults with type 2 diabetes and excess weight lose more weight than a placebo. Participants will receive either AZD6234 or a placebo for 68 weeks, and researchers will meas…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This trial compares two oral medications for active ulcerative colitis, a chronic inflammatory bowel disease causing diarrhea, bleeding, and pain. About 320 Chinese adults will be randomly assigned to take either etrasimod, a newer drug that blocks immune cells from entering the …

This trial is testing whether combining the drug mirikizumab with a surgical procedure can help heal perianal fistulas in people with Crohn's disease. Participants will receive the drug through infusions and injections, along with two surgical steps to clean and close the fistula…

This trial tests a 12-week community program for older stroke survivors who also have high blood pressure or type 2 diabetes. Participants take part in physical activities like exercise and nutrition education, plus cognitive games on an AI-enabled large screen. The goal is to se…

This trial is testing whether adding dapagliflozin to metformin can improve levels of a growth-related hormone (IGF-1) in men with type 2 diabetes and fatty liver disease. The study will include 84 men aged 30-60 who are already taking metformin. Half will continue metformin alon…

This trial aims to find out whether a standard exercise program (Otago) or a specialized balance training that engages multiple senses (multisensory integration) is more effective at improving balance and walking in older adults with type 2 diabetes. Participants, aged 65 to 75, …

This clinical trial aims to find the safest and most effective hepatitis C treatment for people with chronic kidney disease (CKD). Researchers will compare two drug combinations based on how well the kidneys are working: one for patients with moderate kidney function and another …

This study tests whether people with certain gastrointestinal cancers—like stomach, esophageal, or colorectal—can safely skip radical surgery after responding well to precision therapies such as immunotherapy or targeted drugs. Participants with specific molecular markers will be…

This phase II trial is testing whether adding tocilizumab, an anti-inflammatory drug, to a standard two-drug immunotherapy regimen can reduce severe immune-related side effects in people with advanced liver cancer. The study enrolls about 51 adults with hepatocellular carcinoma t…

This trial tests whether a single dose of ferric carboxymaltose can treat iron-deficiency anemia after stomach cancer surgery as effectively as multiple doses of iron sucrose. About 160 adults who had curative stomach cancer surgery and developed anemia will be randomly assigned …

This trial tests whether a wearable device and a personalized prehabilitation program can help adults recover better after surgery for pancreatic cancer or related conditions. Participants will wear a monitor to track vital signs and activity, and follow a program of exercise, nu…

This phase 2 trial is testing whether combining the immunotherapy drug pembrolizumab with a short course of high-dose radiation, with or without additional radiation to nearby lymph nodes, can shrink or eliminate head and neck tumors before surgery. Adults with resectable squamou…

This phase 2 trial is testing whether adding the immunotherapy drug sintilimab and the anti-angiogenic drug suvemcitug to standard chemoradiation can improve outcomes for people with locally advanced rectal cancer that is microsatellite-stable (pMMR). The study plans to enroll 18…

This trial is testing whether adding the immunotherapy drug serplulimab to a standard chemotherapy regimen (SOX) after surgery can help prevent stomach or gastroesophageal junction cancer from coming back. The study includes adults with stage II-III cancer whose tumors show certa…

This trial is testing an experimental procedure called pulsENDO therapy for adults with type 2 diabetes whose blood sugar is not well controlled with current medications. The procedure uses a thin tube to deliver gentle electric pulses to the lining of the small intestine, aiming…

This phase II trial is testing whether adding an experimental immunotherapy drug called AK112 to a standard chemotherapy regimen (gemcitabine, cisplatin, and albumin-bound paclitaxel) can shrink locally advanced gallbladder tumors enough to allow surgery. Adults with gallbladder …

This trial tests whether a home-based prehabilitation program, supported by 5G and artificial intelligence, can help gastric cancer patients prepare for surgery after chemotherapy. The program includes personalized exercise, nutrition, and psychological support, all supervised re…

This trial tests a new laparoscopic procedure called SIBS, which combines sleeve gastrectomy with a side-to-side connection between the duodenum and ileum, without cutting the duodenum. The goal is to see if the surgery is safe and technically feasible in adults with obesity and …

This phase 2 trial is testing whether combining two immunotherapy drugs—vilastobart and retifanlimab—can shrink tumors in people with metastatic pancreatic cancer that has a BRCA1, BRCA2, or PALB2 gene mutation. Participants receive both drugs by IV infusion over several months. …

This phase 2 trial is investigating whether adding a ketogenic diet and/or high-dose intravenous vitamin C to standard chemoradiotherapy and immunotherapy can improve outcomes for patients with locally advanced rectal cancer that is mismatch repair proficient (pMMR/MSS). The stud…

This trial is testing an investigational drug called mizagliflozin to see if it can prevent low blood sugar (hypoglycemia) in people who experience this condition after bariatric surgery. The study will include adults who had Roux-en-Y bariatric surgery more than a year ago and h…

This phase 2 trial is testing whether an investigational drug called SL-325 can help adults with moderate to severe Crohn's disease. The study will compare SL-325 against a placebo to see if it reduces gut inflammation and improves symptoms. Participants will receive the treatmen…

This trial tests whether giving praziquantel three times a year, instead of the standard once a year, can improve liver fibrosis (scarring) caused by schistosomiasis in people aged 15-40 in Uganda. Participants with liver fibrosis will be randomly assigned to one of two treatment…

This trial is testing a new device called MRace to repair a leaky mitral valve in people with severe functional mitral regurgitation, a condition where the valve doesn't close properly, causing blood to flow backward. The device is placed through a vein in the leg and guided to t…

This study tests a new device called MRace, designed to repair severe mitral regurgitation—a condition where the heart's mitral valve doesn't close properly, causing blood to leak backward. The device is implanted through a vein in the leg, avoiding open-heart surgery, and is aim…

This study tests a new device called MRace, designed to repair a leaky mitral valve in the heart without open surgery. The device is placed through a vein in the leg and guided to the heart to help the valve close properly. The trial will include up to 15 people with severe mitra…

This trial is testing whether taking a daily Ceylon cinnamon supplement, combined with a structured educational program, can improve blood sugar control, cholesterol levels, and nerve pain in adults with type 2 diabetes and painful diabetic peripheral neuropathy. About 900 partic…

This phase 2 trial is testing whether adding the immunotherapy drug durvalumab to standard chemotherapy (FLOT before surgery, TS-1 after) can improve outcomes for people with resectable gastric or gastroesophageal junction cancer. The study aims to see if this combination increas…

This trial tests whether open-source automated insulin delivery (AID) systems can control blood sugar as well as commercial systems in adults with type 1 diabetes, even when meals are not announced. Participants will use both types of systems for four weeks each, with a focus on …

This trial is testing whether artificial intelligence can create 'digital twin' models of esophageal cancer patients to predict how they will respond to a combination of immunotherapy and chemotherapy. The study will compare the AI's predictions against real outcomes in patients …

This trial tests whether tirzepatide (Zepbound) can reduce daily bowel frequency in adults with an ileal pouch-anal anastomosis (IPAA) who have chronic high bowel frequency despite standard anti-diarrheal therapy. Participants will be assigned to receive tirzepatide or standard c…

This pilot trial is asking whether emergency abdominal surgery for newborns with a serious gut condition called necrotising enterocolitis should be done in the operating theatre or right on the neonatal unit. It will compare outcomes like stability during surgery, wound infection…

This phase 2 trial is testing whether pirfenidone, a drug already used for lung scarring, can help people with chronic pancreatitis—a long-term inflammation of the pancreas that causes severe pain. The study will enroll 60 adults with chronic pancreatitis and moderate-to-severe p…

This trial is testing whether a special type of radiation called radscopal radiotherapy—which combines low-dose radiation to the main tumor and precise high-dose radiation to distant metastases—can enhance the effects of two immunotherapy drugs (sintilimab and ipilimumab) in peop…

This trial tests whether extending a 6-month exercise coaching program to 12 months helps people with type 2 diabetes maintain a healthier activity level. Participants will be randomly assigned to either the standard 6-month program or an extended version with sessions every two …

This trial is testing whether a probiotic supplement called Colipral, which contains a specific strain of E. coli bacteria, can improve gut health in people with ulcerative colitis who are in remission but still have digestive issues. Participants will take either the supplement …

This early trial is testing an experimental biologic drug called aletekitug in adults with moderate to severe ulcerative colitis. The main goal is to see if the drug is safe and tolerable when given repeatedly. Researchers will monitor side effects and changes in lab tests, vital…

This phase 3 trial is testing whether giving targeted therapies that match specific genetic abnormalities in a person's tumor can delay or prevent biliary tract cancer from coming back after surgery. Participants will have their tumor tested for certain markers, and if found, the…

This trial tests whether a medicine called emapalumab, which calms a specific part of the immune system, can prevent liver failure in children aged 1 year and older with severe hepatitis that hasn't improved with steroids. The study includes a screening group to observe all sever…

This trial tests whether a daily supplement of 5-methyltetrahydrofolate (a form of folate) can improve markers of liver health in people with metabolic dysfunction-associated steatotic liver disease (MASLD), a common type of fatty liver. Over 90 days, participants receive either …

This phase III trial is testing whether switching liver transplant recipients to an everolimus-based, calcineurin inhibitor-free regimen one year after surgery can better preserve kidney function compared to staying on a low-dose calcineurin inhibitor. The study enrolls 150 adult…

This trial is testing whether a combination of two newer drugs—envafolimab and suvemcitug—plus chemotherapy delivered directly to the liver can shrink advanced liver tumors enough to allow surgery. The study enrolls adults aged 18–75 with liver cancer that is currently too advanc…

This phase 3 trial tests whether giving the targeted therapy cetuximab plus FOLFIRI chemotherapy in scheduled breaks works as well as continuous treatment for people with a specific genetic type of metastatic colorectal cancer (RAS/BRAF wild-type). The study compares how long the…

This trial tests whether an artificial intelligence system can tailor the timing of follow-up scans for people who have had liver cancer surgically removed or ablated. Instead of fixed-interval scans every four months, the AI uses routine clinical data to estimate each person's c…

This trial explores whether starting transdermal estradiol (a skin gel or patch) soon after menopause can protect the heart and brain in women who have hot flashes and at least one cardiovascular risk factor. One hundred women will be randomly assigned to receive the hormone ther…

This pilot study tests whether a voice-activated smart speaker can help adults aged 50 and older with poorly controlled type 2 diabetes improve their blood sugar levels. Participants receive weekly diabetes education and skills training calls through the smart speaker for 12 week…

Many people with diabetes skip regular eye exams, even though early treatment can prevent vision loss. This pilot study tests whether offering retinal photography during routine occupational health visits makes screening easier to access. Workers with diabetes attend one visit wh…

Researchers are studying whether immune markers in a blood sample taken before pancreatic cancer surgery can predict a serious complication called postoperative pancreatic fistula, where digestive fluids leak from the surgical connection. Adults scheduled for curative-intent panc…

Doctors usually send colorectal tissue to a lab and wait days for results. This pilot study tests a miniaturized device called MULTISCOPE that uses light-based imaging to tell healthy tissue from cancerous tissue in real time. Researchers will examine 30 tissue samples removed du…

This study checks if a simpler way to collect blood samples works as well as the standard method for the HepQuant DuO liver test. The test involves drinking a natural substance and taking blood samples 20 and 60 minutes later. Researchers will compare different blood collection t…

Researchers are testing whether early symptom relief from tegoprazan can help diagnose gastroesophageal reflux disease (GERD). Adults with frequent heartburn or acid regurgitation take tegoprazan or a placebo once daily for one week. By comparing symptom improvement between the g…

This study tests whether an artificial intelligence (AI) system can help doctors spot more precancerous polyps and colorectal cancers during colonoscopy compared to standard procedures. Over 3,300 adults scheduled for screening or surveillance will be randomly assigned to AI-assi…

Researchers at Assiut University are studying whether two ultrasound measures of fetal heart function and blood flow can predict poor outcomes in pregnancies complicated by diabetes or preeclampsia. The study enrolls 69 pregnant women, including those with gestational diabetes, p…

Researchers at Gaziantep City Hospital are using bedside ultrasound to measure stomach volume in pregnant women right before a scheduled cesarean section. They compare women who have gestational diabetes with those who do not, to see whether diabetes affects how much food or flui…

Many cancer trials require patients to have specific molecular markers, so researchers test large numbers of people to find the few who qualify. This study evaluates FATHOM, an AI system that reads clinical trial records and routine tumor slides to predict which patients carry th…

Researchers are testing whether artificial intelligence can assess colorectal cancer risk by analyzing facial features, tongue images, and exhaled breath. The study enrolls adults aged 18 to 80 who are scheduled for a colonoscopy, collecting their multimodal data before the proce…

This study compares two needle devices used to take tissue samples from pancreatic lesions during an endoscopic ultrasound. The goal is to see which device provides better quality tissue for diagnosis with fewer needle sticks. About 30 adults with pancreatic solid lesions larger …

This trial tests whether a laser-based imaging device can help surgeons assess blood flow in the bowel during rectal cancer surgery. About 100 adults with rectal cancer will have the laser imaging performed alongside standard fluorescence imaging. The goal is to see if the laser …

Colonoscopy helps doctors find and remove polyps that can turn into bowel cancer, but the right side of the bowel often stays dirty even after standard preparation, so polyps there can be missed. This trial tests whether giving a small sodium phosphate enema into the right colon …

Researchers test a new endoscopic device called the loop brush fine needle aspiration (lbFNA) to sample pancreatic cysts in people scheduled for surgery. The pilot study enrolls 8 adults with cysts that require surgical removal. Doctors use the device to puncture, brush, and aspi…

Researchers at Assiut University are studying whether two types of routine blood measurements can help predict how quickly kidney disease worsens in people with diabetes. The first is the Triglyceride-Glucose index, a calculation from standard cholesterol and blood sugar tests. T…

Researchers at the University of British Columbia are collecting intestinal ultrasound images from adults, including healthy people and those with inflammatory bowel disease such as Crohn disease or ulcerative colitis. The goal is to build a computer program that can measure bowe…

Researchers at Mayo Hospital Lahore are studying whether the Surgical Apgar Score can identify patients who need direct admission to the intensive care unit after emergency abdominal surgery. The score uses three factors recorded during surgery: estimated blood loss, lowest mean …

This study is testing whether two different ultrasound measurements can predict a sudden drop in blood pressure that sometimes happens when anesthesia is given. The trial will include adults aged 40 to 70 with intestinal obstruction who are having exploratory abdominal surgery. R…

Researchers at Assiut University Children Hospital are measuring fecal calprotectin, a protein linked to gut inflammation, in preterm infants. The study compares levels between babies who develop necrotizing enterocolitis and those who do not, and between exclusively breastfed an…

Researchers are testing whether a previously validated artificial intelligence model can help identify high-grade dysplasia or pancreatic cancer in real time during a procedure called digital per-oral pancreatoscopy. The study enrolls 60 adults who need this procedure for suspect…

This study tests whether two simple blood markers, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), can signal inflammation caused by Helicobacter pylori infection in the stomach. Researchers will compare these ratios in adults with dyspepsia who h…

Pancreatic cancer is hard to catch early, and screening guidelines for high-risk people remain uncertain. Researchers at UNC are testing an electronic decision support tool that guides patients and doctors through a shared conversation about whether to screen. The pilot study enr…

Researchers at Assiut University are testing whether a stool test for calprotectin, a protein linked to inflammation, can accurately detect gut inflammation in children with chronic digestive symptoms. The study will compare stool test results with findings from endoscopy and tis…

Peritoneal dialysis uses the belly lining as a natural filter for people with kidney failure, but over time this membrane can scar and stop working. This study tests whether levels of a protein called DKK3 in blood, urine, and dialysis fluid can serve as an early warning sign of …

This registry study follows 400 people at increased risk for pancreatic ductal adenocarcinoma who receive PancreaSure, a blood test designed to detect early-stage disease. Researchers track whether the test results lead doctors to change surveillance plans, such as scheduling mor…

This trial tests whether a new non-invasive device, called Body Surface Colonic Mapping, can accurately measure colon movement in children. The device uses a sticky pad with electrodes placed on the abdomen to detect electrical activity from the colon. Researchers will compare it…

This study focuses on American Indian communities, who face high colorectal cancer death rates. Researchers will test a program where a navigator helps clinics and patients schedule diagnostic colonoscopies within 60 days after a positive screening. The goal is to improve early d…

This trial tests two new imaging modes, VIST and SFI, during colonoscopy to see if they help doctors find and classify colorectal polyps better than standard white light. About 990 adults undergoing screening or surveillance colonoscopy will be randomly assigned to one of the thr…

This study tests whether special MRI scans can predict how well HPV-positive throat cancer responds to standard chemotherapy and radiation. Researchers will scan 30 adults before treatment and track their outcomes. The goal is to see if MRI patterns can identify low-risk patients…

This study tests whether using an AI program to screen for diabetic eye disease during regular primary care visits can get more people to follow up with an eye specialist. It will include 4,000 adults with diabetes who have Medicaid and haven't had an eye exam in the past year. T…

Researchers are testing whether an artificial intelligence tool can measure fibrosis, or scarring, in intestinal biopsies from people with Crohn's disease. The study will use previously collected biopsy samples and medical records from 100 adults to see if the AI's fibrosis score…

This study tests whether community pharmacies can help find undiagnosed type 2 diabetes and prediabetes in adults living in Irbid, Jordan. Participants without a diabetes diagnosis will fill out a risk questionnaire and, if their score is high, receive a quick finger-prick HbA1c …

This trial tests whether measuring glucose in umbilical cord blood, already collected at birth, can screen newborns for congenital hyperinsulinism, a condition that causes dangerously low blood sugar and can lead to brain damage if missed. Researchers will check the test's accura…

This study is testing whether a combination of simple, non-invasive tests—like a liver scan and blood samples—can accurately detect advanced liver fibrosis (scarring) in people at risk for fatty liver disease. Researchers will follow 1,200 adults aged 40 to 70 who have obesity, t…

This pilot study is testing whether a rapid, point-of-care blood test can help identify early signs of infection and sepsis in preterm infants. Researchers will measure inflammatory markers like IL-6, PCT, CRP, and MxA in blood samples from about 40 to 80 premature babies, compar…

This trial aims to develop and validate a standardized MRI protocol for staging esophageal squamous cell carcinoma and assessing how well tumors respond to neoadjuvant therapy. About 500 adults scheduled for surgery will be enrolled, with some undergoing MRI before surgery and ot…

This study looks at whether a special ultrasound technique called detective flow imaging (DFI) can help doctors tell the difference between benign and malignant solid pancreatic lesions. Researchers will examine the blood vessel patterns seen with this technique and compare them …

This study investigates whether tiny particles shed by tumors into the blood, called extracellular vesicles, can serve as a non-invasive biomarker for metastatic colorectal cancer. Researchers will analyze blood samples from 290 patients at different treatment stages to see if th…

This study tests whether combining two stool tests—fecal immunochemical test (FIT) and fecal calprotectin (FC)—can accurately detect precancerous or cancerous changes in people with long-standing ulcerative colitis. Participants will provide stool samples and then undergo a speci…

This trial tests whether an AI system called GI Genius can help doctors accurately tell apart small colorectal polyps (5 mm or less) during a colonoscopy—identifying which ones are harmless versus those that need monitoring. For each small polyp, doctors first record their own di…

Researchers are testing an AI chatbot that gives personalized, culturally tailored advice on nutrition, physical activity, and goal setting to adults at risk for type 2 diabetes. About 30 adults aged 18 to 55 will use the chatbot for 6 weeks. The study will check whether the chat…

This study tests whether an enhanced version of the Intensive Diabetes Prevention Program (IDPP) works better than the standard program at recruiting and keeping participants in district health centres. Researchers will compare the two approaches in 170 adults with prediabetes, l…

Pancreatitis is a painful inflammation of the pancreas that can happen after an ERCP procedure. Doctors often give rectal indomethacin around the time of ERCP to lower that risk, but it still occurs. This trial randomly assigns adults having ERCP to receive either rectal indometh…

Researchers are testing an experimental drug called INCA33890 in people with stage II or III colorectal cancer who have finished surgery and chemotherapy but still have tiny amounts of tumor DNA in their blood. This leftover DNA, called circulating tumor DNA or ctDNA, can signal …

Researchers are testing whether an intensive Mediterranean diet program started in the first trimester of pregnancy lowers the chance of developing gestational diabetes in women at high risk. The trial enrolls about 1,200 pregnant women aged 18 to 50 with a single, unassisted pre…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

Researchers are testing whether a nasal catheter that diverts stool from the small intestine can prevent leaks after surgery for mid to low rectal cancer. The trial compares this catheter approach with a standard protective ileostomy, a temporary opening in the abdomen to divert …

Many homes in rural Central Appalachia rely on private wells and springs rather than treated utility water. Researchers are testing whether giving households a multi-stage point-of-use water filter reduces acute gastrointestinal illness and waterborne infections. The trial enroll…

Researchers are testing whether adding family health history and family participation to the standard Diabetes Prevention Program helps adults with prediabetes. The trial enrolls 400 adults with prediabetes and a family member who joins them. Participants are assigned to either t…

Researchers at New York University are testing whether a package of online tools can help low-income families with teens at risk for type 2 diabetes buy and eat more fruits, vegetables, and legumes. The trial enrolls 200 households that receive SNAP or have low incomes and includ…

Hirschsprung's disease is a rare birth defect where part of the bowel lacks nerve cells, causing blockage. Even after surgery to remove the affected section, many children still struggle with constipation, bloating, or a dangerous gut inflammation called enterocolitis. Researcher…

This study tests whether delivering prepared meals or boxes of unprepared food to pregnant people at risk of gestational diabetes is practical and acceptable. Researchers will give participants either ready-to-heat meals from a diabetes-friendly menu or boxes with fresh produce a…

This trial tests whether giving semaglutide (Wegovy) to women shortly after a pregnancy affected by gestational diabetes can reduce their risk of developing metabolic syndrome, a cluster of conditions that raise the chance of heart disease and diabetes. About 226 postpartum women…

This trial tests a program where trained community members, called Colon Health Champions, lead discussions about colorectal cancer risk and screening barriers. The goal is to see if this peer-led approach is feasible and acceptable for adults aged 45 to 75 who are due for routin…

This phase 3 trial tests whether orforglipron, a daily oral medication, can help overweight adults reduce their risk of developing obesity-related complications such as type 2 diabetes, high blood pressure, and high cholesterol, as well as progression to class 1 obesity. Particip…

This Phase 2 trial tests whether psilocybin, a psychedelic compound, can prevent or lessen chemotherapy-induced peripheral neuropathy (nerve damage) in people with breast, colorectal, or head and neck cancer. About 83 participants will receive either psilocybin, a low-dose placeb…

This trial tests whether a single intravenous dose of tacrolimus, given just before an ERCP procedure, can lower the chance of developing post-ERCP pancreatitis (PEP) in adults at moderate-to-high risk. Participants receive either tacrolimus or a placebo infusion, along with stan…

This trial tests whether combining time-restricted eating (eating only within a 10-hour window each day) with moderate-to-high intensity exercise can improve heart and metabolic health in women who recently had gestational diabetes. Participants are randomly assigned to either an…

This trial tests whether applying 5-ASA (mesalamine) directly to the ileal pouch after surgery for ulcerative colitis can prevent pouchitis—a painful inflammation that affects more than half of patients. Adults with UC who are scheduled for pouch surgery are randomly assigned to …

Researchers are testing a program that combines mindful eating and yoga-based movement for adults with type 2 diabetes. The trial enrolls 60 people aged 40 and older who have had diabetes for at least six months. Half receive the mindfulness program and half receive standard diet…

Researchers are testing whether intermittent fasting improves quality of life for adults with acute or chronic pancreatitis. Participants follow a daily 16-hour fast or receive standard calorie guidance. The study measures pancreas-related quality of life, pain, opioid use, weigh…

Researchers compare two approaches to care after ileostomy reversal surgery in children. One group receives the Enhanced Recovery After Surgery (ERAS) protocol, which includes early feeding, early catheter removal, early walking, and multimodal pain control. The other group recei…

Researchers are studying whether a procedure called fluoroscopy-guided transdiscal splanchnic nerve neurolysis can safely reduce severe upper abdominal pain in adults with pancreatic, gastric, or hepatobiliary cancer. Participants first receive a diagnostic nerve block with local…

Researchers are testing whether a digital nutrition app called STRONG, paired with remote dietitian counseling, is practical and helpful for adults with pancreatic ductal adenocarcinoma who are starting chemotherapy or radiation. About 80 participants join the study and are assig…

This study looks at whether bringing in palliative care early during an unplanned hospital stay can reduce aggressive treatments at the end of life for people with advanced cancer. About 493 adults with metastatic digestive, gynecological, ENT, or sarcoma cancers will be randomly…

Researchers are testing whether personalised nutritional care from a trained dietitian improves quality of life for people aged 65 and older with pancreatic ductal adenocarcinoma. About 250 participants will be randomly assigned to either six months of individualised nutrition su…

Researchers at the University of Michigan are studying whether a home device called Transcutaneous Electrical Acustimulation (TEA) can help adults with cirrhosis manage chronic pain. The trial enrolls 100 people who report ongoing pain on most days. Participants use either a real…

This trial tests whether a traditional Chinese music therapy, called Ziwu Liuzhu Five-Element Music Therapy, can reduce anxiety in people with pancreatic cancer who are undergoing chemotherapy. The study will enroll 320 patients with mild-to-moderate anxiety and randomly assign t…

Researchers compare two surgical methods for removing an inflamed appendix in obese patients: laparoscopic (keyhole) surgery and traditional open surgery. The trial enrolls 166 obese adults with acute appendicitis, randomly assigning each to one of the two procedures. The main go…

Researchers are testing a diabetes education program that combines standard self-management lessons with hands-on activities involving miniature horses. Children and teens ages 8 to 20 with type 1 or type 2 diabetes, along with their caregivers, attend four sessions led by a diab…

Intrahepatic cholestasis of pregnancy is a liver condition that causes severe itching and can pose risks to both mother and baby. Researchers are testing whether an oral drug called maralixibat is safe and well tolerated in pregnant women with this condition. All 15 participants …

People with spinal cord injuries often rely on a bowel program to manage neurogenic bowel, a condition that makes it hard to control bowel movements. This trial compares three tools used during those programs: a bisacodyl suppository, a mini enema called Enemeez, and a transanal …

This study tests whether a 15-week well-being program can improve mood, reduce IBS symptoms, and boost quality of life in 150 adults with Irritable Bowel Syndrome. Participants will attend weekly one-hour sessions and be followed for up to 9 months. The goal is to see if focusing…

A loose seton is a thread surgeons place through a complex anal fistula to keep it draining. This pilot study follows 50 adults who already have a polypropylene seton and whose surgeon decides, as part of routine care, to replace it with a braided polyester one. Researchers ask e…

Diabetic foot ulcers heal in only about half of patients, even with standard care. Researchers are testing a turmeric-derived nanoparticle hydrogel applied to the wound alongside usual treatment, such as medication, insulin, or surgery. The trial enrolls adults with type 1 or typ…

This study tests a mobile app designed to help Black and Hispanic adults with inflammatory bowel disease (IBD) manage stress and improve their quality of life. The app teaches coping skills, mindfulness, and disease acceptance. Researchers want to see if the app is practical and …

This trial tests whether a personalized 6-month exercise program can reduce persistent fatigue in people with inflammatory bowel disease (IBD) who are in remission. Researchers will randomly assign 120 participants to either the exercise program or usual care. Fatigue levels are …

Researchers at Mayo Clinic are running a pilot study to see whether clearing a blocked pancreatic duct improves how the pancreas makes insulin in people with chronic pancreatitis. Participants are adults with minimally symptomatic chronic pancreatitis and a duct blockage. The stu…

Researchers are testing DiaFootCare, a mobile app that teaches foot self-care, sends medication and care reminders, guides users through taking wound photos, and shares information with pharmacists. The trial enrolls 139 adults aged 40 to 60 with diabetes and an active foot ulcer…

This phase 2 trial tests whether a combination of fosamprenavir (an HIV medication) and sodium alginate (a seaweed-based thickener) can ease heartburn and regurgitation in people whose reflux doesn't improve with standard acid-blocking pills. Sixty adults aged 18 to 65 will take …

Researchers are testing whether placing small bands in the lower esophagus can create a barrier against stomach acid and ease GERD symptoms. The trial enrolls people with symptomatic GERD who have not had previous reflux surgery. Participants undergo an endoscopic procedure to pl…

Researchers are testing whether adding the probiotic yeast Saccharomyces boulardii to standard care helps children aged 6 months to 5 years recover faster from acute diarrhea. All children receive fluids and zinc, and half also receive the probiotic from hospital admission to dis…

This pilot study tests whether delivering pain medication directly to the spinal cord via an implanted pump can better control severe pain in people with pancreatic cancer. The trial enrolls adults whose pain is not well managed by standard treatments or who cannot take typical p…

Researchers are testing whether foot care education delivered with digital tools helps people with type 2 diabetes take better care of their feet. Ninety participants are randomly assigned to either a structured education program or standard care. The program includes two face-to…

Cancer near the liver's bile duct junction can block bile flow, causing jaundice and infection. Doctors usually drain the bile with a plastic stent placed through an endoscope. This trial randomly assigns about 70 adults with inoperable high-grade hilar biliary obstruction to one…

Achalasia makes it hard to swallow because the valve between the esophagus and stomach stays tight. Researchers randomly assign 220 adults with newly diagnosed achalasia to two procedures that cut that valve muscle: POEM, done through the mouth with no skin cuts, or laparoscopic …

Colorectal cancer patients who live with a stoma often face stigma, social anxiety, and loneliness. Researchers are testing a six-week mindfulness and self-compassion program adapted for these patients. The pilot trial enrolls 20 adults who have finished active treatment and spea…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This trial tests a virtual mind-body group program for female survivors of colorectal and anal cancer who experience sexual well-being challenges. Participants join weekly group sessions with other survivors to learn coping skills for physical changes, social factors, and thought…

This study tests whether an 8-week mindfulness-based stress reduction (MBSR) program can lower stress and improve well-being in people with inflammatory bowel disease (IBD). Seventy adults with mild-to-moderate IBD will either take the MBSR course online or watch an educational s…

This trial tests whether a structured, one-on-one educational session led by a nurse before an endoscopic retrograde cholangiopancreatography (ERCP) can reduce patient anxiety and improve knowledge about the procedure. Sixty adults scheduled for elective ERCP will be randomly ass…

This trial tests whether a TAP block, an injection of local anesthetic into the abdominal wall, can reduce pain after laparoscopic gallbladder surgery. Researchers will compare 200 patients who receive the block with those who do not, measuring pain scores, painkiller use, and ho…

This trial tests whether a lidocaine gel applied to the feet can ease painful diabetic neuropathy as well as the oral drug duloxetine. Adults with type 2 diabetes and moderate-to-severe nerve pain will be randomly assigned to one of the two treatments for 8 weeks. Researchers wil…

This study tests whether a 10-session virtual group psychotherapy program can help people with inflammatory bowel disease (IBD) who also have anxiety or depression. The therapy is adapted from a standard manual called Mind Over Mood and includes education on the brain-gut connect…

This study tests a new way to fix hernias using a needle guided by ultrasound, avoiding large cuts and general anesthesia. It is for adults who cannot or do not want standard surgery. About 30 people will be followed for 8 months to see if the procedure is safe and improves quali…

This trial tests two drug-free programs to help adults with cirrhosis manage everyday pain. One group gets a self-guided digital platform with automated messages, while the other adds personalized coaching, group sessions, and a structured walking or meditation plan. Researchers …

This trial tests whether a traditional Chinese exercise called Baduanjin can improve quality of life and emotional well-being in people with pancreatic cancer who are receiving chemotherapy. Researchers will enroll 96 patients and randomly assign them to either a 12-week Baduanji…

This trial tests whether a virtual reality version of Mindfulness-Based Stress Reduction (MBSR-VR) can be delivered to young adults aged 16 to 20 with type 1 diabetes who report high stress. Participants will attend group sessions that teach meditation, body awareness, and mindfu…

This study asks whether drinking kefir every day can reduce gastrointestinal symptoms and improve quality of life in adults with celiac disease who follow a strict gluten-free diet. In a crossover design, 30 participants will consume 200 mL of kefir daily for four weeks, then con…

This trial tests whether a structured art therapy program, grounded in positive psychology, can improve self-compassion and hope in children aged 8 to 12 who are staying in a hospital ward. Half of the 80 participants will receive the art therapy sessions alongside standard nursi…

This trial investigates whether a traditional Chinese medicine formula, Xingqi Daozhi Decoction, can relieve constipation that often occurs as a side effect of antipsychotic medications in people with schizophrenia. The study will enroll 46 adults with schizophrenia who have deve…

This study tests whether a 4-week rehabilitation program is practical and helpful for patients who experience severe complications after pancreatic surgery. The program includes personalized exercise, nutritional guidance, and techniques to reduce anxiety, and can be done at home…

This trial compares two types of exercise—calisthenics (bodyweight moves like squats and planks) and cycling—to see how they affect inflammation and quality of life in young women with irritable bowel syndrome (IBS). Participants, aged 18 to 25, will follow an exercise program wh…

This phase III trial tests whether a daily probiotic supplement, OXXYSLAB®, can reduce peripheral neuropathy—nerve damage causing pain and numbness—in people with stage III colon cancer receiving oxaliplatin-based chemotherapy (FOLFOX or XELOX). About 130 participants will take e…

Researchers at Assiut University are studying whether an underactive thyroid makes liver scarring worse in people with metabolic dysfunction-associated steatotic liver disease (MASLD). The trial enrolls 120 adults with MASLD, half of whom have overt or subclinical hypothyroidism …

This study follows 500 adults and children who are getting a stem cell transplant to see how their liver is affected. Researchers will track liver function, perform biopsies and scans, and look for factors that lead to liver damage. The goal is to better understand and eventually…

Researchers are observing 300 adults aged 60 and older with inflammatory bowel disease who are starting an advanced therapy chosen by their usual care team. The study tracks immune-aging markers such as CD4/CD8 ratio and IL-6, along with frailty and nutrition, over 52 weeks. The …

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

Autoimmune hepatitis makes a child's immune system attack their liver. Researchers at Assiut University Children's Hospital want to know how many children with this liver condition also develop thyroid disorders such as Hashimoto thyroiditis or Graves' disease. The team will test…

This study will follow 100 adults with Crohn's disease, ulcerative colitis, or other IBD, plus their healthy relatives, for up to 3 years. Researchers will collect blood, stool, tissue samples, and imaging to track how immune cells and genetics change over time. The goal is to fi…

This study will test whether combining continuous glucose monitor (CGM) data with information from a smartwatch and a phone app (like meals and activity) can better predict blood sugar levels in people with type 2 diabetes. Thirty-six adults will wear a CGM and smartwatch and log…

This observational study gathers information from routine care on how localized rectal cancer is treated across Austrian hospitals. It aims to document the variety of treatment approaches, including total neoadjuvant therapy and immunotherapy, and their outcomes. By analyzing thi…

Researchers are testing whether blocking three inflammation pathways at once (TL1A, IL-23, and α4β7) calms inflamed intestinal tissue more effectively than blocking each pathway alone. The study enrolls 30 people: 10 with ulcerative colitis, 10 with Crohn's disease, and 10 withou…

This pilot study looks at whether it is safe to stop giving antibiotics after surgery for a burst (perforated) appendix. About 100 adults will be randomly assigned to receive either antibiotics or no antibiotics after their operation. The main goal is to see if a larger study is …

This study will test if an AI chatbot can give helpful nutrition advice to pregnant women. About 100 women will either use the chatbot or get standard care. The goal is to see if the chatbot is easy to use and if it helps improve diet and knowledge about conditions like gestation…

Researchers at Assiut University Hospitals are studying whether a simple calculation from two routine blood tests, the leukocyte glucose index, relates to how severe diabetic ketoacidosis becomes in adults with diabetes. The index multiplies white blood cell count by blood sugar …

Researchers are reviewing medical records of 100 people with esophageal squamous cell carcinoma who received immunotherapy plus chemotherapy before surgery to remove the cancer. The study examines when and where cancer returns and which patient traits, treatment details, scan res…

This study looks at how anxiety, depression, and stress might cause advanced IBD treatments to stop working. Researchers will ask 450 people with IBD to fill out questionnaires about their mental health while they receive regular infusions. The goal is to understand if mental hea…

People with type 2 diabetes often have high lactate levels, which researchers link to heart failure and thinking problems. This early study uses a carbon-13 MRI contrast agent called hyperpolarized pyruvate to watch how the heart and brain process pyruvate, lactate, and bicarbona…

Researchers at Al-Azhar University are studying whether type 2 diabetes is linked to changes in women's hair and scalp. The study compares 130 women aged 20 to 60, half with diabetes for at least a year and half healthy controls matched by age. Participants undergo clinical hair …

Researchers at Kırıkkale University are studying how GLP-1 receptor agonists, drugs prescribed for type 2 diabetes and obesity, affect saliva and oral health. Fifty adults aged 18 to 65 who are newly prescribed these drugs provide saliva samples and undergo dental exams at the st…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

This study aims to develop a method using advanced MRI scans to predict whether rectal cancer has been completely eliminated after chemoradiation. About 115 patients will be enrolled to test the accuracy of this MRI-based prediction. If it works, some patients might safely avoid …

Researchers at Assiut University Children Hospital are comparing conventional and biologic therapies in children and adolescents with inflammatory bowel disease, including Crohn's disease and ulcerative colitis. The study tracks about 100 patients to measure clinical remission at…

Irritable bowel syndrome looks different from person to person, and doctors usually classify it by bowel habits alone. This study asks 500 adults with a confirmed IBS diagnosis to complete a detailed online questionnaire covering symptoms, mood, diet triggers, sleep, and digital …

Researchers at Karolinska University Hospital are following 900 people diagnosed with intrahepatic or perihilar cholangiocarcinoma, two types of bile duct cancer. The study tracks how tumors respond to treatment, how patients feel and function, and changes in biomarkers over time…

Researchers are studying whether extracellular vesicles released by pancreatic islets can indicate islet quality and be used to improve their fitness before transplantation. The trial involves adults with type 1 diabetes who are on the waiting list for an islet transplant. The go…

This study is exploring whether a rapid, non-invasive stool test can help monitor inflammatory bowel disease (IBD) in children. The test uses a technology called differential mobility spectrometry (DMS) to analyze the molecular profile of stool samples. Researchers will compare t…

Some people with inflammatory bowel disease who take anti-TNF drugs develop painful rashes in skin folds and around the mouth, a condition called SPIDER. Researchers at a French hospital are studying whether levels of Staphylococcus aureus bacteria in these rashes change over six…

Laparoscopic fundoplication relieves reflux for most GERD patients, but 10 to 30 percent still have symptoms or side effects afterward. Researchers at Minia University Hospitals follow 470 adults scheduled for this keyhole surgery, measuring ten factors before the operation such …

Rectal cancer treatment can involve chemotherapy, radiation, surgery, or watch-and-wait surveillance, and each can affect bowel, urinary, sexual, and stoma function. Most studies measure quality of life at a single point or after one type of treatment, leaving gaps in how patient…

Children who suffer traumatic injuries and severe bleeding can develop shock, which slows blood flow to the gut and delays stomach emptying. When food or fluid stays in the stomach, it raises the risk of vomit entering the lungs during emergency breathing tube placement or surger…

Researchers are studying whether repeated bedside ultrasound scans of the neck, chest, and abdomen can be done reliably in hospitalized patients with cirrhosis and ascites. The study also asks how long the scans take, how often all measurements can be captured, and how patients f…

This study looks at children and teenagers with type 1 diabetes to see how many have abnormal liver function tests. Researchers will check blood samples for signs of liver stress and try to find patterns or risk factors. The goal is to understand whether liver issues are common i…

Researchers at Mass General Brigham are testing whether genetic information can help identify people who might benefit from early screening for type 1 diabetes, even before they feel sick. The study involves 150 adults from the MGB Biobank who agreed to be recontacted. Participan…

Researchers are testing a visual sampling capsule that collects fluid from different parts of the intestine without surgery. They will use it in 250 people, including those with active or remission Crohn's disease or ulcerative colitis, plus healthy volunteers. By analyzing the m…

This phase 1 trial asks whether a single dose of tirzepatide changes how quickly the stomach empties in adults with type 1 diabetes who are overweight or have obesity. Researchers will give participants either tirzepatide or a placebo injection, then measure stomach emptying usin…

This observational study tests whether artificial intelligence can predict how well pancreatic cancer responds to chemotherapy and how the disease may progress. Researchers will analyze data from 700 patients, including endoscopic ultrasound images, CT/MRI scans, lab results, and…

This study will watch how doctors use a special camera (endoscopic ultrasound) to diagnose suspected pancreatic or bile duct diseases in 2500 adults across Lombardy, Italy. The goal is to see how accurate the procedure is, how safe it is, and how quickly patients get a final diag…

Researchers are testing whether standard blood tests can indicate the quality of stem cells taken from the heel bone during foot or ankle surgery. The study includes adults aged 40 to 80, some with type 2 diabetes and diabetic foot ulcers. Before surgery, participants give blood …

This study follows 328 adults aged 60 and older who are having surgery for gastric cancer. Researchers will measure frailty, nutrition, and muscle mass before surgery, then track complications, delirium, and recovery afterward. The goal is to see whether these factors, along with…

This study looks at whether showing AI suggestions a few seconds later helps doctors make better decisions when diagnosing small colon polyps. Seventy endoscopists will watch 100 polyp videos, with some seeing AI advice right away and others seeing it after a delay. The goal is t…

This observational study tracks how patients with stage II to IVB gastric or gastroesophageal junction cancer are actually treated in routine clinical practice across Greece. Researchers will collect data on patient characteristics, treatment choices, timing of therapies, and bio…

This study looks at how 'leaky' the gut is and what bacteria live in the intestines of 150 very low birth weight preterm babies. Researchers want to understand why some babies develop a life-threatening gut emergency called NEC. They will measure gut permeability using harmless s…

This study looks back at medical records from high-volume hospitals in Russia and China to compare how patients with stomach cancer or cancer at the junction of the stomach and esophagus fare after a specific surgery called proximal gastrectomy with double-tract reconstruction. R…

This observational study follows 400 people with intermediate to advanced or unresectable hepatocellular carcinoma (the most common type of liver cancer) who are receiving systemic therapies such as atezolizumab plus bevacizumab or nivolumab plus ipilimumab, sometimes combined wi…

This study investigates whether the bacteria living in the gut influence the development of diverticular disease and acute diverticulitis. Researchers will compare the gut microbiota of people with and without these conditions to identify differences and risk factors. The goal is…

This study enrolls adults with stomach or gastroesophageal junction cancer who had a strong response to chemotherapy before surgery, with no or very little cancer left in the removed tissue. Researchers will use a personalized blood test that tracks tumor DNA to see if it can ide…

Doctors in the ICU often check blood gases through an arterial line, but that carries risks like clots and infection. This study asks whether blood drawn from a central venous line, which is already in place for other care, gives equally useful information. Researchers will compa…

Researchers at Assiut University are studying how nutrition, diet-related inflammation, and blood markers relate to disease activity in people with inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. The study will enroll 100 adults aged 18 to…

This study looks at whether routine blood test results can help predict which patients with acute pancreatitis will develop severe disease or die within 28 days. Researchers will track 109 adults admitted with acute pancreatitis and compare their blood cell ratios, such as neutro…

Researchers are studying whether common clinical signs and blood tests can predict short-term death in people with cirrhosis who develop acute kidney injury. They will follow 100 hospitalized adults and look at factors like fluid buildup, brain function, and levels of creatinine …

This study enrolls 150 adults with suspected or confirmed pancreatic cancer who are scheduled for chemotherapy. Researchers will collect tumor samples via endoscopic ultrasound before and during treatment to analyze gene activity. They aim to understand how the cancer changes acr…

This study investigates how different genetic pathways affect the body's response to food and to a short course of orforglipron, an oral GLP-1 drug used for weight management and blood sugar control. Researchers will enroll about 100 adults, with or without type 2 diabetes, who a…

Researchers at National Taiwan University Hospital are looking back at records of adults who came to the emergency department with right-sided belly pain and were diagnosed with either epiploic appendagitis or diverticulitis. They will compare symptoms, lab results, and CT and ul…

This study investigates whether the speed at which blood sugar falls after starting a new diabetes medicine affects small blood vessels in the eye. Adults with type 2 diabetes who are beginning a GLP-1 receptor agonist or an SGLT2 inhibitor will undergo advanced eye scans and blo…

Researchers at Fudan University are testing whether an artificial intelligence tool can score bowel preparation quality by measuring fecal coverage during colonoscopy. The study enrolls 560 adults aged 45 to 75 who have not had a colonoscopy in the past three years. The goal is t…

This study follows 100 adults with diabetes who are on peritoneal dialysis or about to start it. Researchers use a continuous glucose monitor to track blood sugar levels over time. They will look for links between glucose patterns and health events like hospitalizations, heart pr…

This trial tests whether people living with HIV can collect their own anal swabs for anal cancer screening, compared with swabs taken by a clinician. About 700 participants in Australia will provide both types of swabs, which will be checked for high-risk HPV and precancerous cel…

This study tests a remote education program to help people at higher risk for pancreatic cancer learn about genetic testing and a blood test that screens for multiple cancers. The program targets Black, Latino/a, and Medicaid-enrolled individuals in Massachusetts who may have had…

This study explores whether providing home self-sampling kits for six sexually transmitted infections (STIs) can help sex workers get tested more easily. Participants receive a kit to collect samples at home and return them by mail, along with a questionnaire about their backgrou…

This study explores the real-life experiences of adults with type 2 diabetes who have used a continuous glucose monitoring (CGM) device daily for at least a year. Through in-depth interviews, researchers aim to uncover the benefits and challenges people face with these devices. T…

This study looks at how children and teens with type 1 diabetes use the Omnipod 5, a tubeless insulin pump that automatically adjusts insulin based on glucose readings. Researchers will track how quickly families adopt the system, who chooses it, and how it affects blood sugar co…

This study looks at anonymized health records from about 100,000 people in a Turkish hospital network to see how common cardiometabolic conditions—like obesity, type 2 diabetes, heart disease, fatty liver, and kidney disease—are and how often they occur together. By tracking thes…

This observational study looks at whether critically ill adults on ECMO—a machine that supports heart and lung function—experience delayed stomach emptying more often than those on a breathing machine only. Researchers will measure stomach emptying using bedside methods like ultr…

This study looks at whether children with celiac disease may have a higher risk of heart rhythm problems compared to healthy children. Researchers will measure specific heart rhythm intervals using an ECG in children diagnosed with celiac disease and compare them to healthy child…

This study compares two standard pre-surgery treatments for a common type of esophageal cancer: chemoradiotherapy (radiation plus chemo) versus immunochemotherapy (immunotherapy plus chemo). Using data from 400 patients' medical records, researchers will analyze which approach is…

This observational study looks at whether combining several scoring tools—measuring fatigue, frailty, overall health, and liver disease severity—can better predict short-term outcomes for adults with cirrhosis who are waiting for a liver transplant. The researchers will track ear…

This observational study looks at whether changes in liver stiffness, measured by a device called iLivTouch, can predict serious liver-related events and death in people with fatty liver disease that has progressed to advanced scarring. The study follows over 2,000 adults with th…

This observational study will follow 1,500 adults with chronic pancreatitis for several years, collecting health data and biological samples like blood, stool, and bile. The goal is to track how the disease changes over time, especially in those undergoing ERCP treatment, and to …

This study tests whether continuous glucose monitors (CGMs) like the Dexcom G7 can be safely and effectively used in intensive care units. The monitors provide real-time blood sugar readings and alarms for dangerously high or low levels, potentially reducing the need for frequent…

This observational study looks at how pancreatic cancer changes immune cells in the blood. Researchers will compare blood samples from 50 people with newly diagnosed, untreated pancreatic cancer to 50 age-matched people with a non-cancerous pancreatic condition. They aim to ident…

This study looks at whether a structured surveillance program using regular ultrasound and a blood test (alpha-fetoprotein) can detect liver cancer at an earlier, more treatable stage in people at high risk. About 300 adults with liver cirrhosis, chronic hepatitis B, or advanced …

This study looks at people who had surgery for advanced lower rectal cancer, comparing two procedures: one that removes the rectum and anus (requiring a permanent stoma) and one that removes the rectum but keeps the anus (with a reconnection). The goal is to see which approach le…

This study looks at how bariatric surgery affects the liver's energy processing in people with obesity and fatty liver disease. Researchers will use safe, non-radioactive tracer infusions and MRI scans before, during, and six months after surgery to measure changes in liver metab…

This trial investigates how the severity of liver cirrhosis changes the way the body processes certain drugs. Adults with mild, moderate, or severe cirrhosis will receive a single low dose of five common drugs—caffeine, warfarin, esomeprazole, metoprolol, and midazolam—each used …

This study looks at whether a combination of immune cell activity, genetic changes, and imaging features can help predict if colorectal cancer that has spread to the liver will come back after surgery. Researchers will analyze tumor tissue, blood samples, and scans from about 210…

This study looks at the long-term urinary, sexual, and bowel health of people aged 7 to 25 who had surgery for Hirschsprung disease as young children. Hirschsprung disease is a rare birth defect where part of the large intestine lacks nerve cells, causing blockages. Surgery remov…

This study investigates why children with inflammatory bowel disease (IBD) have an overactive immune response in the gut, and whether blood stem cells can be engineered to restore tolerance. Researchers will analyze blood and intestinal tissue samples from 80 children with IBD, w…

This observational study looks at whether the total antioxidant capacity of a person's diet is linked to levels of inflammation and nutritional health in adults with type 2 diabetes. Researchers will compare people with well-controlled blood sugar to those with poorly controlled …

This study looks at whether levels of a protein called Neuregulin-4 (NRG4) in the blood are linked to obesity, insulin resistance, and different diabetes treatments in people with type 2 diabetes. Researchers will compare NRG4 levels across groups including obese and non-obese pa…