Digestive system disorder

Researchers are testing whether a combination of two immunotherapy drugs, tremelimumab and durvalumab, can treat MSI-high gastric or gastroesophageal junction cancer without immediate surgery. The trial enrolls adults with resectable tumors and gives the drugs before a planned op…

This trial tests whether giving immunotherapy drugs before surgery can completely eliminate tumors in patients with a specific type of stomach or gastro-esophageal junction cancer that has a high number of genetic mutations. Participants will receive either one drug (zimberelimab…

This phase 2 trial is testing whether a short course of radiation followed by a powerful three-drug chemotherapy regimen (FOLFOXIRI) can completely eliminate tumors in people with locally advanced rectal cancer before they undergo surgery. The study enrolls adults aged 18 to 70 w…

This phase 2 trial is testing whether a therapeutic cancer vaccine called AST-301 can safely train the immune system to fight HER2-expressing gastric cancer cells. The study enrolls people with stage II or III gastric cancer who have already had surgery and completed standard adj…

This study tests a vaccine that helps the body's immune system recognize and attack advanced colon polyps, which can turn into cancer. About 110 people who have had these polyps removed will receive either the vaccine or a placebo. The goal is to see if the vaccine boosts immune …

This trial tests a new vaccine called LBVD, which combines protection against six diseases: diphtheria, tetanus, whooping cough, hepatitis B, polio, and Hib. The study enrolls healthy infants around 6 to 8 weeks old who receive three doses at 6, 10, and 14 weeks of age. Researche…

This trial is testing whether giving a single dose of radiation directly to the tumor area during surgery is safe for people with localized pancreatic cancer. Participants first receive standard chemotherapy and stereotactic body radiation therapy (SBRT), then at the time of surg…

This study tests an experimental drug, GSK4532990, in 284 adults with nonalcoholic steatohepatitis (NASH) and advanced liver scarring. The goal is to see if the drug can improve liver fibrosis and inflammation compared to a placebo over 52 weeks. Participants must have a liver bi…

This study tests a device called the iLet Bionic Pancreas, which automatically adjusts insulin delivery based on continuous glucose monitor readings, in people with cystic fibrosis-related diabetes. About 150 participants aged 14 and older will either use the bionic pancreas or t…

This early-phase trial tests whether adding triapine to standard radioactive therapy (lutetium Lu 177 dotatate) is safe and effective for people with advanced neuroendocrine tumors of the digestive system. About 31 participants whose tumors have worsened after prior treatment wil…

This Phase II trial tests whether combining lenvatinib and everolimus can shrink or slow advanced carcinoid tumors that cannot be removed by surgery. The study enrolls 36 adults with confirmed unresectable carcinoid tumors. Both drugs are taken orally and work by blocking enzymes…

This expanded access program provides continued treatment with CA102N plus lonsurf to a single patient with advanced or metastatic colorectal cancer. The patient had already completed at least 12 cycles of the same combination in an earlier clinical study. Expanded access allows …

Researchers compare two ways to remove large, non-cancerous growths from the colon. One method, endoscopic mucosal resection, removes the growth in pieces. The other, endoscopic submucosal dissection, removes it in one piece but takes longer and carries more risk. The trial tests…

This study tests a new drug called AZD7798 in 120 people with moderate to severe Crohn's disease. The goal is to see if it can reduce symptoms and improve the appearance of the gut lining. Participants are randomly assigned to receive either the drug or a placebo, and neither the…

This trial tests an artificial intelligence system called ADTPS that helps doctors remove early-stage esophageal cancer or precancerous lesions using a scope. The AI analyzes live images during the procedure and overlays a suggested cutting path on the screen. Half of the partici…

Researchers are testing whether adding an experimental drug called CA102N to the chemotherapy TAS-102 helps control metastatic colorectal cancer better than adding bevacizumab to TAS-102. The trial enrolls about 100 adults whose cancer has grown after standard chemotherapy. Parti…

This pilot study tests whether giving a combination of two immunotherapy drugs (nivolumab and ipilimumab) along with chemotherapy and radiation therapy before surgery can help treat stomach cancer that can be surgically removed. The study includes 32 participants and primarily lo…

This early-phase trial tests a freezing treatment called cryotherapy, given before and during standard chemoradiation, for people with locally advanced esophageal cancer. The main goal is to find the safest number of cryotherapy sessions. Researchers will also check if the freezi…

This study looks at how well a new insulin called icodec controls blood sugar in adults with type 2 diabetes who are switching from their current daily insulin. About 214 participants in Italy will use icodec as prescribed by their doctor for 22 to 30 weeks. Researchers will meas…

This study tests whether the Ask Me 3® educational program, which encourages patients to ask three key questions during doctor visits, can improve blood sugar control in adults with type 2 diabetes. Participants are randomly assigned to receive the program plus standard care or s…

Researchers compare two biologic drugs, ustekinumab and infliximab, in adults with moderate to severe ulcerative colitis who have not previously tried biologic therapy. The trial measures how well each drug reduces inflammation, controls symptoms, and improves quality of life, wh…

This phase III trial compares an experimental drug called YL201 with standard chemotherapy in people whose nasopharyngeal carcinoma has returned or spread and no longer responds to PD-(L)1 inhibitors and at least two prior chemotherapy regimens. About 400 participants will receiv…

This study will test a new robotic device called the Triton 1.5 System for performing colonoscopies, which are exams to look for colon cancer. About 40 adults who need a routine colonoscopy will take part. The main goal is to see if the robot is safe and can successfully complete…

This study tests a new drug called SKB264 in people with advanced solid tumors that have not responded to standard therapies. The drug is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells. The trial includes over 1,400 participants with various …

Researchers are collecting data on how well donor livers preserved with the LIVERguard device function after transplantation. The study includes liver transplant recipients whose donor organs were stored in the device, as well as a comparison group of patients who received livers…

This phase 2 trial tests the drug pasireotide in 93 adults who experience severe low blood sugar after weight-loss surgery. Participants receive either the drug or a placebo for 12 weeks, then all can receive the drug for 36 more weeks. The goal is to see if pasireotide can stabi…

This early-stage trial is testing an experimental oral drug called RGT-61159 in about 105 people with two types of cancer that have come back or stopped responding to treatment: adenoid cystic carcinoma (a rare salivary gland cancer) and colorectal cancer. The main goals are to c…

Researchers are testing whether adding the immunotherapy drug camrelizumab to chemotherapy or chemoradiotherapy before surgery helps people with locally advanced esophageal squamous cell carcinoma. The trial enrolls adults with resectable tumors who have not received prior treatm…

This study tests an experimental drug called RO7790121 in about 21 adults with moderate to severe Crohn's disease who haven't responded well to other treatments. The goal is to see if the drug can reduce gut inflammation and improve symptoms like diarrhea and stomach pain. Partic…

This study tests a new drug called ARV-806 in adults with advanced solid tumors that have a specific KRAS G12D mutation. The drug aims to break down the mutated protein that helps tumors grow. The trial has two parts: first, finding a safe dose in small groups, then testing that …

This study tests a new drug called ASKB589 combined with chemotherapy and an immunotherapy for people with advanced stomach or gastroesophageal junction cancer that has spread. The trial includes 780 participants whose tumors have a specific marker (CLDN18.2). The goal is to see …

This study is for people with liver cancer who need surgery but don't have enough healthy liver left. Doctors use a special radiation treatment (Y90) to help the liver grow larger. Once the liver is big enough, patients can have surgery to remove the cancer. The study compares st…

This study gives the drug metreleptin to 29 people with partial lipodystrophy, a rare condition that causes high blood fats and diabetes. Participants have already shown improvement from the drug in earlier studies. The goal is to keep providing the treatment and check its long-t…

This study tests AIDANET, an automated insulin delivery algorithm, in 40 adults with type 1 diabetes. Participants will use the system in three modes: fully automatic (no meal announcements), hybrid (with meal announcements), or a mix. The goal is to see which mode keeps blood su…

This study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes severe fat loss and leads to high blood fats and diabetes. Participants, aged 6 months and older, have already received metreleptin in past NIH studies but cannot get it i…

This study tests three drugs—durvalumab (an immunotherapy), olaparib (a DNA repair blocker), and cediranib (a blood vessel growth blocker)—in different combinations for people with advanced solid tumors, especially ovarian cancer. The phase 1 part finds safe doses, and the phase …

This early-phase trial tests a new treatment called NG-350A, a virus designed to stimulate the immune system inside tumors, combined with standard chemoradiotherapy for people with locally advanced rectal cancer. The study aims to see if this combination can improve the chance of…

This early-stage study tests an experimental drug called ALN-4324 in two groups: healthy overweight volunteers and overweight patients with type 2 diabetes. The goal is to check the drug's safety and how well it controls blood sugar. Participants receive either the drug or a plac…

This study looks at the long-term safety and effectiveness of balinatunfib, an oral tablet, in adults with Crohn's disease or ulcerative colitis. Participants have already completed a one-year treatment in a previous study. The trial will last up to 107 weeks and includes both do…

This study looks at how well a new once-weekly insulin, called insulin icodec, works for people with type 2 diabetes who are switching from a daily insulin. Researchers will track blood sugar control, treatment satisfaction, and how well patients stick to the new regimen over abo…

Steroid injections for knee arthritis can temporarily raise blood sugar in people with type 2 diabetes. This trial tests whether giving a short course of NPH insulin right after the injection can prevent those high blood sugar episodes. Adults with type 2 diabetes and knee osteoa…

Researchers are testing whether human umbilical cord mesenchymal stem cells can help people with end-stage liver disease, and whether the route of delivery changes the outcome. Participants receive the cells either through a peripheral vein or through the hepatic artery. The tria…

This early-phase trial tests a new treatment called RPCAR01 for people with advanced liver cancer that has not responded to standard therapies. The treatment uses a patient's own immune cells, modified in a lab to better recognize and attack cancer cells that carry a protein call…

This early-stage trial tests a therapeutic vaccine called ISA104 in 24 people with chronic hepatitis B who are already on antiviral drugs. The goal is to see if the vaccine is safe and can boost the immune system to better fight the virus. Participants will receive either ISA104 …

This phase 2 trial is testing whether a shorter course of radiation therapy, given alongside standard chemotherapy, can effectively treat high-risk anal cancer. The standard treatment typically requires about 6 weeks of daily radiation, which can be a heavy burden for patients. T…

Researchers are testing whether a blood test that detects tiny amounts of tumor DNA can guide chemotherapy after surgery for early colon cancer. The trial compares two chemotherapy regimens: an intensive one called FOLFOXIRI and a standard one called CAPOX. They want to see if th…

This study is testing three long-acting antibodies, alone or in combination, in 645 people with ulcerative colitis. The goal is to see if they are safe and can improve bowel inflammation over 48 weeks. Participants are joining from a previous study and may have already seen some …

This trial tests whether a multilingual interactive voice response (IVR) system can help adults with type 2 diabetes and low health literacy adjust their insulin doses. Participants use a feature phone to report blood sugar levels and receive algorithm-guided dose recommendations…

This study tests a combination of two drugs, candonilimab and LM-302, in people with advanced biliary tract cancer that has stopped responding to standard chemotherapy and immunotherapy. The goal is to see if the combination can shrink tumors or control the disease. About 78 part…

This early-stage trial is testing whether combining valemetostat tosylate with two different antibody-drug conjugates (T-DXd or Dato-DXd) is safe and effective for people with advanced solid tumors. About 210 adults with at least one measurable tumor will receive the drugs orally…

This study tests whether giving a higher, targeted radiation dose to the main tumor and nearby lymph nodes can improve outcomes for people with locally advanced rectal cancer. About 128 adults whose cancer has not spread beyond the pelvis will receive either standard radiation or…

This Phase III trial tests whether giving radiation in three smaller doses (FSRS) works better than a single large dose (SRS) for cancer that has spread to the brain. About 269 adults with lung, breast, melanoma, kidney, or gastrointestinal cancers will be randomly assigned to on…

Researchers are testing an experimental antibody called ONC-392 in people with advanced solid tumors, including non-small cell lung cancer and melanoma. The trial gives ONC-392 alone or with pembrolizumab, an approved immunotherapy, to see what doses are safe and how the body pro…

This study tests a program called 'Type 1 Doing Well' for youth aged 10–13 with type 1 diabetes and their parents. The program uses a smartphone app, goal-setting, and family meetings to build on the teen's diabetes strengths. Researchers want to see if it improves blood sugar co…

This phase III trial compares the standard immunotherapy drug pembrolizumab alone versus pembrolizumab plus radiation therapy in 290 patients with metastatic head and neck cancer. The goal is to see if adding radiation improves overall survival. Participants receive pembrolizumab…

This study tests a freezing device (CryoBalloon) to treat Barrett's esophagus that hasn't improved after multiple standard heat treatments. About 70 adults with precancerous changes in the esophagus will receive the freezing therapy. The goal is to safely remove all abnormal tiss…

This Phase 3 trial tests whether the drug Afimkibart can help people with moderate-to-severe ulcerative colitis achieve remission. About 400 adults who have not responded well to other treatments will receive either Afimkibart or a placebo. The study measures remission at 12 and …

This study tests a combination of two drugs, BXCL701 and pembrolizumab, in 22 people with advanced pancreatic cancer that has spread. The goal is to see if this treatment can stop the cancer from growing for at least 18 weeks. Participants must have already tried one prior treatm…

This early-phase trial tested a combination of focused radiation and an immunotherapy drug called bintrafusp alfa in just 2 patients with advanced bile duct cancer that had spread. The goal was to find the safest dose and see if the combo could help control the cancer. The study …

This study looks at whether giving chemotherapy both before and after surgery helps people with stage II-III gallbladder cancer live longer compared to the usual approach of only giving chemo after surgery. About 186 participants will be randomly assigned to one of two groups. Th…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

Researchers at Stanford University are testing whether a program that combines weekly healthy food deliveries with group lifestyle coaching helps Latino patients with type 2 diabetes. The study enrolls adults who receive care at partner clinics, have type 2 diabetes, and report f…

This phase II trial is testing whether a lower dose of chemotherapy plus radiation can work as well as the standard dose for early-stage anal cancer. The study includes 252 adults with T1-2N0M0 anal cancer. The goal is to see if the gentler approach controls the disease while imp…

This study tests a combination of two immunotherapy drugs (durvalumab and tremelimumab) as a first treatment for people with advanced liver cancer that cannot be removed by surgery. About 111 participants will receive the drugs to see how safe they are and whether they shrink tum…

This trial is testing whether giving the immunotherapy drug pembrolizumab before surgery can improve outcomes for people with high-risk stage 2 or stage 3 colorectal cancer that has a specific genetic feature called mismatch repair deficiency. About 88 participants will receive p…

This study tests different combinations of chemotherapy drugs, along with surgery, for children and young adults with two types of liver cancer: hepatoblastoma and hepatocellular carcinoma. The goal is to see which combinations work best to stop tumor growth and improve survival.…

This phase II trial tests whether combining two drugs, atezolizumab and bevacizumab, can shrink rare solid tumors like appendix cancer, anal cancer, and mesothelioma. About 133 participants with various rare cancers will receive the drugs intravenously. The goal is to see if the …

This phase II trial is testing whether giving two drugs—atezolizumab (an immunotherapy) and bevacizumab (which blocks blood vessel growth)—before surgery can help prevent liver cancer from returning. The study enrolled 16 adults with resectable liver cancer. The main goals are to…

This phase III trial is testing whether adding radiotherapy to standard chemotherapy improves survival in patients with HER2 negative esophageal or gastric cancer that has spread to a few other spots in the body (oligometastatic). About 314 participants will receive either chemot…

This pilot study tests whether adding the immunotherapy drugs cemiplimab (with or without fianlimab) after a standard liver cancer procedure called Y90 radioembolization can help control hepatocellular carcinoma. About 20 adults with liver cancer will be randomly assigned to one …

People with liver cirrhosis can develop dangerous bleeding from swollen veins in the esophagus or stomach. Doctors use endoscopy to find and treat the bleeding, but they do not know the best time to do it. This trial randomly assigns patients to different endoscopy timings to see…

This study tests three different chemotherapy combinations in people aged 70 or younger with newly diagnosed mantle cell lymphoma, a type of blood cancer. The goal is to see if adding a targeted drug called acalabrutinib to standard chemo improves how well the cancer responds. Ar…

This study tests whether adding the targeted therapy cabozantinib to a standard immunotherapy combination (nivolumab and ipilimumab) can better control advanced nasopharyngeal cancer that has returned or spread. About 50 adults whose cancer worsened after platinum chemotherapy an…

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can help lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will receive either CBT-I or a patient education program. The main goal is to see if improv…

This early-phase study tests a two-part approach for people with advanced pancreatic cancer. First, a special scan identifies cancer cells. Then, a targeted radioactive treatment is given to destroy those cells. The goal is to check safety and find the right dose in 30 participan…

This phase 3 trial is testing whether adding the immunotherapy drug nivolumab to standard chemotherapy (carboplatin and paclitaxel) helps people with metastatic anal cancer live longer without their disease getting worse. About 205 adults with inoperable or recurrent anal cancer …

Researchers are testing whether a structured primary care program can help adults aged 40 to 90 with higher heart or diabetes risk reach recommended prevention targets. The program trains doctors and nurses, uses routine data to flag at-risk patients before visits, and provides d…

This early-stage trial tests a DNA vaccine called INO-8000, given with an immune booster, to see if it can help people with chronic hepatitis C fight the virus. The study involves 33 participants and focuses on safety and finding the best dose. The vaccine is delivered through in…

This study tests whether adding two experimental drugs (elraglusib and losartan) to standard chemotherapy (FOLFIRINOX) can prevent metastatic pancreatic cancer from becoming resistant to treatment. About 70 adults with untreated, advanced pancreatic cancer will receive the combin…

This phase II trial is testing whether adding the drug veliparib to standard chemotherapy (gemcitabine and cisplatin) can shrink tumors or slow cancer growth in people with advanced pancreatic cancer who have BRCA1, BRCA2, or PALB2 gene mutations. The study has two parts: one com…

This early-phase study tests a new drug, RO7247669, that targets two immune system checkpoints (PD-1 and LAG-3) to help the body fight cancer. About 170 adults with advanced solid tumors (including melanoma, lung cancer, and esophageal cancer) who have run out of standard options…

Researchers are testing a shorter radiation schedule for people with head and neck cancer who have had surgery. Standard radiation after surgery often takes several weeks, but this trial gives five treatments over five days. The study enrolls 50 adults with high-risk features, su…

This Phase 2 study tests a new injectable drug called maridebart cafraglutide in 409 adults with type 2 diabetes. The main goal is to see if it improves blood sugar control compared to a placebo. Researchers will also check if it helps with weight loss. The trial is active but no…

This study tests an experimental drug called SAR441566 in about 204 adults with moderate-to-severe ulcerative colitis, a chronic bowel disease causing inflammation and symptoms like diarrhea and bleeding. Participants will receive either the drug or a placebo for up to 52 weeks t…

This phase 2 trial tests whether taking aspirin can prevent Barrett's esophagus from returning after it has been successfully removed with radiofrequency ablation. Researchers will measure levels of a protein linked to Barrett's in tissue samples from 21 participants over 12 mont…

This phase 2 trial tests a combination of two drugs, atezolizumab and cabozantinib, in 30 people with metastatic pancreatic cancer that has not responded to standard treatments. The goal is to see if the combination can shrink tumors or stop them from growing. Researchers will al…

This early-phase trial is testing an experimental drug called TTX-080, which blocks a protein (HLA-G) that tumors use to hide from the immune system. The study will give TTX-080 alone or combined with other cancer drugs (pembrolizumab, cetuximab, or FOLFIRI plus cetuximab) to abo…

This phase 2 trial is testing whether combining an experimental drug called S-531011 with a precise radiation technique known as RadScopal can help control metastatic colorectal cancer that has not responded to prior treatments. The study enrolls about 30 adults with advanced dis…

This Phase 2 study tests an experimental drug called ALG-000184 against a standard hepatitis B medication (tenofovir) in 200 adults with chronic hepatitis B. Participants take one pill daily for 48 weeks. The main goal is to see if the new drug can lower hepatitis B virus levels …

This study tests an experimental oral drug called GS-5290 (tilpisertib fosmecarbil) in 176 adults with moderate to severe ulcerative colitis. Participants are randomly assigned to receive either the drug or a placebo for 12 weeks. The main goal is to see if the drug can improve s…

This study is testing two simple tools to help women with type 2 diabetes better manage their condition and understand reproductive health risks. The tools include a personalized medication list for patients and an alert for doctors during checkups. Researchers will track blood s…

This Phase 2 trial tests whether adding TQ-A3334 tablets to standard nucleoside analog drugs can better control chronic hepatitis B. About 116 adults with the infection will receive either the combination or a placebo plus standard drugs. The main goal is to see if the combinatio…

This study tests an experimental drug called SAR441566 in 260 adults with moderate to severe Crohn's disease. Participants will receive different doses of the drug or a placebo for up to 52 weeks to see if it reduces gut inflammation and improves symptoms. The goal is to find a s…

This early-phase study is testing a new drug called JZP815 in people with advanced or spreading solid tumors that have specific changes in the MAPK pathway. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. About 332 adults who h…

This phase III trial tests whether adding the immunotherapy drug nivolumab after standard combined modality therapy (chemo and radiation) can improve outcomes for patients with high-risk stage IIB-IIIC anal cancer. About 344 participants will receive nivolumab or a placebo. The m…

Researchers are testing whether aerobic exercise, resistance exercise, or a combination of both can reduce liver fat in adults with metabolic dysfunction-associated steatotic liver disease. The trial enrolls 186 people aged 18 to 45 with a body mass index between 25 and 40 and ev…

This trial tests whether trained village health workers, using a smartphone app, can provide effective type 2 diabetes care in rural Lesotho. 252 adults with diabetes will either receive community-based care (lifestyle advice, metformin, statins) or be referred to a clinic. The g…

This study tests two methods for adjusting basal insulin in people with type 2 diabetes who fast during Ramadan. One method follows standard guidelines, while the other uses a personalized carbohydrate fasting test. The goal is to see which approach better controls blood sugar an…

This study tests a device called ColoSeal ICD that is placed inside the colon after surgery to divert stool away from the surgical connection. The goal is to see if it is safe and feasible in 90 adults with rectal or rectosigmoid cancer. The device stays in place for about 10 day…

This study tests whether a blood test for Epstein-Barr virus (EBV) DNA can help doctors choose the best chemotherapy after standard radiation for nasopharyngeal cancer. About 685 patients will first receive standard chemoradiation. Then, based on whether EBV DNA is still detectab…

Researchers are studying how the length of bypassed intestine during gastric bypass affects weight loss, complications, and metabolic changes in people with severe obesity. Participants will have different lengths of intestine bypassed and will provide blood and stool samples bef…

This early-phase trial tests a new drug called BAY 1895344 combined with standard chemotherapy (irinotecan or topotecan) in people with advanced solid tumors, especially small cell lung cancer, poorly differentiated neuroendocrine cancer, and pancreatic cancer. The goal is to fin…

This trial tests a procedure called High-Intensity Focused Ultrasound (HIFU) for people with pancreatic cancer that cannot be removed by surgery. The study has two parts: first, checking how safe the procedure is, and second, seeing if it helps patients live longer. About 26 part…

Researchers compare a very low calorie ketogenic diet with a Mediterranean-style low-calorie diet in 40 adults who have type 2 diabetes, obesity, and non-alcoholic fatty liver disease. Participants follow one of the two diets for several weeks. The study measures changes in weigh…

This study tests whether giving immunotherapy before surgery can help people with MSI/dMMR tumors. The goal is to shrink or eliminate the tumor before it is removed, potentially improving survival. The trial includes adults with localized, resectable cancers such as colorectal, g…

This phase 2 trial tests whether adding the immunotherapy drug serplulimab to standard chemotherapy before surgery helps patients with advanced stomach or gastroesophageal junction cancer. About 116 participants will receive either the combo or chemo alone for three cycles before…

This long-term study tests the safety and effectiveness of bitopertin (DISC-1459) in people with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP), rare conditions that cause severe pain from sunlight exposure. About 230 participants who previously took bitoper…

This study tests whether adding the drug cixutumumab to standard chemotherapy (paclitaxel) can help people with advanced esophageal or stomach-junction cancer live longer without their cancer growing. About 94 adults whose cancer has spread and who have already tried one treatmen…

This early-phase trial tests VX-264, a therapy made from stem cells that produce insulin, in 7 people with long-standing type 1 diabetes. The goal is to see if it is safe and can help control blood sugar. If successful, it may reduce or replace the need for insulin injections.

Researchers at a Prague hospital are observing whether ursodeoxycholic acid, a drug used for certain liver conditions, affects liver fat, liver enzymes, and markers of heart and blood vessel health in people with non-alcoholic fatty liver disease. The study includes 20 adults who…

Upper abdominal pain often comes from functional dyspepsia, irritable bowel syndrome, or uncomplicated gallstones. These conditions overlap and many patients do not know that tests and surgery may not help. Researchers are testing a personalized web-based education tool that expl…

This phase 2 trial tests the drug sorafenib in 38 patients with gastrointestinal stromal tumor (GIST) that has worsened despite treatment with imatinib and sunitinib. Sorafenib works by blocking enzymes that help tumors grow and by cutting off blood supply to the cancer. The stud…

This Phase 2 study tests whether adding leronlimab to standard chemotherapy and a targeted drug can shrink tumors or improve survival in people with a specific type of advanced colorectal cancer (MSS mCRC) that has not responded to prior treatments. About 66 adults will receive o…

This study is for people with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP), rare conditions that cause severe pain and skin reactions to sunlight. The purpose is to check the long-term safety of an oral medication called dersimelagon. About 301 participant…

This study tests whether delivering healthy food boxes, remote health monitoring, and one-on-one coaching can help low-income Black adults with type 2 diabetes better control their blood sugar. The trial enrolls 304 participants in the Deep South and tracks changes in HbA1c level…

Researchers are observing how elexacaftor/tezacaftor/ivacaftor triple combination therapy affects people with cystic fibrosis in routine care. The study follows two groups: children aged 6 to 11 and people aged 12 and older. Over seven years, they measure lung function, inflammat…

This study looks at whether semaglutide, a medicine for type 2 diabetes, can slow or prevent diabetic eye disease over 5 years. About 1500 adults with type 2 diabetes will receive either semaglutide or a placebo injection once a week, in addition to their usual diabetes medicatio…

This early-phase study tested a combination of three drugs (gemcitabine, dasatinib, and erlotinib) in 19 people with advanced pancreatic cancer that had spread or could not be removed by surgery. The main goal was to find the safest dose and look at side effects. Researchers also…

People with MEN1 syndrome inherit a high risk of developing multiple pancreatic neuroendocrine tumors. Surgery is the only curative option but causes major complications. Researchers are testing high-dose, high-precision MR-guided radiotherapy to see if it can shrink these tumors…

This early-stage trial tests a new drug called CA-4948 combined with standard chemotherapy (gemcitabine and nab-paclitaxel) in people with pancreatic cancer that has spread or cannot be removed by surgery. The goal is to find the safest dose and see if the combination can shrink …

This Phase 2 trial tests whether adding a personalized cancer vaccine (autogene cevumeran) and an immunotherapy drug (atezolizumab) to standard chemotherapy (mFOLFIRINOX) can keep pancreatic cancer from coming back after surgery. About 260 people whose tumors were completely remo…

This study tests a drug called olaparib in people with advanced cancers (like brain tumors, bile duct cancer, or other solid tumors) that have a specific gene change called IDH1 or IDH2 mutation. The drug works by blocking an enzyme that cancer cells need to grow. About 89 partic…

This trial is testing whether adding an experimental immunotherapy (QL1706) to a standard chemotherapy regimen (DOS) before surgery can help people with locally advanced stomach or gastroesophageal junction cancer. The goal is to see if the combination can completely eliminate th…

This Phase 3 study tests whether a daily pill combining obicetrapib and ezetimibe, or obicetrapib alone, can lower LDL (bad) cholesterol more than placebo in 300 people with type 2 diabetes or metabolic syndrome. Participants continue their standard cholesterol medications. The m…

Researchers are testing whether combining FLOT chemotherapy, trastuzumab and toripalimab before and after surgery helps people with HER2-positive stomach or esophagogastric junction cancer. The trial enrolls about 30 adults with locally advanced, operable tumors. Participants rec…

This study tests adding the immunotherapy drug durvalumab to standard chemoradiation for people with esophageal or gastroesophageal junction cancer. About 64 participants will receive the combination to see if it is safe and effective. The goal is to improve cancer control withou…

This study tests an experimental oral medication, KAI-7535, taken once daily to help people with obesity or overweight lose weight. About 320 adults with at least one weight-related condition (like high blood pressure or sleep apnea) will receive either the drug or a placebo for …

This study looks at whether a simple blood test can find tiny bits of cancer DNA left after surgery and chemotherapy for stage III colon cancer. If the test is positive, patients may get extra treatment with chemotherapy or immunotherapy to try to wipe out any remaining cancer ce…

This study observes how well insulin icodec controls blood sugar in 245 people with type 1 diabetes who have never used it before. Participants take the insulin as prescribed by their doctor, and researchers track changes in HbA1c and treatment satisfaction over about 22 to 30 we…

This study tests whether adding a person's own bone marrow stem cells to their islet transplant can help the islets survive longer and work better. It includes 42 adults with chronic pancreatitis who are already scheduled for pancreas removal and islet auto-transplant. Participan…

This study is for people with a certain genetic type of advanced colorectal cancer (BRAF V600E) who previously benefited from a specific drug combination (encorafenib plus cetuximab). Researchers want to see if giving these drugs again, guided by a blood test that looks for cance…

This phase 3 trial tests a drug called teduglutide in 13 Chinese adults with short bowel syndrome who rely on IV nutrition. Participants get a daily injection for 24 weeks to see if it reduces their need for IV support. The study also checks safety and how the body processes the …

This Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts a…

This Phase 2 trial tests two experimental injections, HRS-7249 and SHR-1918, in 108 adults with severely high triglycerides who are at high risk of acute pancreatitis. The study aims to see if these drugs can safely lower fat levels in the blood and reduce the chance of a pancrea…

This early-phase study tests a combination of two targeted drugs (vismodegib and erlotinib) with or without a standard chemotherapy drug (gemcitabine) in people with advanced pancreatic cancer or other solid tumors that cannot be removed by surgery. The main goal is to find the s…

This phase III trial compares two first-line treatments for people with a specific genetic subtype of metastatic colorectal cancer (dMMR/MSI-H). One group receives the immunotherapy drug atezolizumab alone, while the other gets atezolizumab combined with chemotherapy (FOLFOX) and…

This phase II trial tests whether adding an experimental drug called SHR-1701 to a standard chemotherapy regimen can improve outcomes for people with pancreatic cancer that is resectable or borderline resectable. Participants receive the combination before surgery, with the goal …

This study tests a mix of three drugs (durvalumab, bevacizumab, tremelimumab) plus a procedure called TACE (which delivers chemotherapy beads to the liver) in people with advanced liver or bile duct cancer. The goal is to see if this combination can stop the cancer from growing f…

This trial tests whether a combination of two common antihistamines, cetirizine and famotidine, can reduce symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D). Participants take the antihistamines or a placebo for 30 days, then switch, so each person ser…

This trial tests whether giving the immunotherapy drug durvalumab along with standard chemotherapy before surgery can shrink high-risk liver cancer (cholangiocarcinoma) and reduce the amount of tissue that needs to be removed. About 27 patients with resectable tumors will receive…

Researchers are testing a digital program called Centering Appetite in African American adults with type 2 diabetes and binge eating. The program includes web-based lessons to help people relearn their body's hunger and fullness signals, along with diabetes education and a Fitbit…

This study tests a new medicine called cagrilintide to help people who are overweight or have obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to see how much weight they lose and how …

This early-phase trial is testing a combination of two drugs—trastuzumab deruxtecan (a targeted chemotherapy) and ceralasertib (a drug that may block cancer cell repair)—in people with advanced solid tumors that have a HER2 mutation. The study has two parts: first, finding the sa…

This study tests whether semaglutide, a medicine already used for type 2 diabetes, can help people with NASH, a serious liver condition. About 1205 adults with NASH and liver scarring (stage 2 or 3) will receive weekly injections of semaglutide or a placebo for up to 5 years. The…

This early-phase study tests the safety and best dose of a drug called veliparib when given with two chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors that have spread or can't be removed. It includes patients who also have liver or kidney probl…

This early-stage trial tests an experimental drug called ONO-4578, both on its own and together with another experimental drug, ONO-4538, in people with advanced or metastatic solid tumors. The study also includes separate groups for people with gastric cancer or colorectal cance…

This study looks at the safety and effectiveness of Velsipity tablets taken daily for up to 52 weeks by people with moderate to severe ulcerative colitis. About 553 participants will be followed in real-world medical settings. The goal is to see if the drug can help control sympt…

This early-phase trial tests whether adding a cancer-killing virus called OBP-301 to standard chemotherapy and radiation is safe for people with advanced esophageal or gastroesophageal cancer who cannot have surgery. The virus is designed to infect and destroy tumor cells. Sixtee…

This phase III trial tests whether giving chemotherapy before and after surgery (perioperative) works better than giving it only after surgery (adjuvant) for people with pancreatic cancer that can be removed. The study involves 358 participants and uses a combination of four chem…

This study will test whether an artificial intelligence (AI) system can help community doctors better manage patients who have high blood pressure along with diabetes or high cholesterol. About 6,800 adults will be split into two groups: one where doctors use the AI tool to guide…

This study looks at whether a team of clinical pharmacists and community health workers can help people with type 2 diabetes improve their blood sugar levels using continuous glucose monitors (CGMs). About 318 adults aged 25-75 with high blood sugar will be enrolled. The goal is …

This trial tests whether an AI system that flags at-risk Medicare Advantage members and suggests care actions, reviewed by a nurse, can reduce overall healthcare spending over a year. About 9,900 participants in Utah are assigned to either this AI-supported navigation or usual ca…

This study tests a new medicine, EYP-1901, given as an eye injection to people with diabetic macular edema (DME), a condition that causes blurry vision in people with diabetes. The goal is to see if EYP-1901 works as well as the standard treatment (aflibercept) but with fewer inj…

This trial compares two surgical procedures for people with gastroesophageal reflux disease (GERD) and a hiatal hernia. One procedure, called transoral incisionless fundoplication (TIF), is done through the mouth without cuts. The other, laparoscopic Nissen fundoplication (LNF), …

This phase 2 trial is testing whether giving the immunotherapy drug pembrolizumab first, followed by a combination of ramucirumab and paclitaxel, can shrink tumors and delay progression in people with advanced gastric or gastroesophageal junction adenocarcinoma. The study enrolls…

This study tests whether text message reminders and a smart pillbox can help teenagers and young adults take their daily anti-rejection medicine on time after a kidney or liver transplant. About 65 participants aged 13-25 will use an electronic pillbox that tracks when they take …

This early trial tests a radioactive drug called MNPR-101-PCTA-177Lu in adults with advanced solid tumors, including bladder, breast, lung, and pancreatic cancers. Participants receive three equal doses by IV over two 12-week cycles. The main goal is to find a safe dose and under…

This study tests whether simple text messages and online activities can encourage people with Type 2 Diabetes to get more preventive dental care, like cleanings, instead of waiting for expensive treatments. Researchers will track dental insurance claims from 10,000 adults over 18…

This phase 3 trial tests EYP-1901, a new eye injection, against the standard treatment aflibercept for diabetic macular edema (DME), a condition that causes vision loss in people with diabetes. The study will enroll 240 participants and compare how well each drug improves vision …

This clinical trial is testing several combinations of immunotherapy drugs to see if they can shrink or control advanced liver cancer. The study is for people with a type of liver cancer called hepatocellular carcinoma (HCC) that has spread or cannot be removed by surgery. Partic…

This trial tests whether adding dihydroartemisinin, a malaria drug, to a standard chemotherapy plus immunotherapy combo can shrink or eliminate colorectal tumors in people whose cancer has not spread widely or has returned after first-line treatment. The goal is to make surgery m…

This early-stage trial tests an experimental mRNA-based cancer vaccine (mRNA-4157) in 161 people with solid tumors. The vaccine is designed to train the immune system to attack cancer cells. Some participants receive the vaccine alone, while others get it with the immunotherapy d…

This phase 2 trial tests whether giving pembrolizumab, bevacizumab, and chemotherapy before surgery can improve outcomes for people with a common type of locally advanced rectal cancer. The cancer must be microsatellite stable, which typically does not respond well to immunothera…

This phase 2 trial tests two oral drugs, abrocitinib and ritlecitinib, in 78 people aged 12-35 who were diagnosed with type 1 diabetes within the last 100 days. The goal is to see if these JAK inhibitors can help preserve the body's ability to produce insulin, measured by a stimu…

This study tests a new drug called INCB099280 in 73 people with advanced solid tumors who have not received immunotherapy before. The goal is to see if the drug can shrink tumors and to check for side effects. The study focuses on safety and how well the drug works in the short t…

This Phase 3 trial tests whether bitopertin, a daily pill, can help people with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP) spend more time in sunlight without pain. About 183 participants aged 12 and older will take bitopertin or a placebo for 6 months. …

This phase II trial compares a three-drug chemotherapy combination (FOLFIRINOX) against standard two-drug combos (FOLFOX or CAPOX) in 783 patients with locally advanced rectal cancer. The goal is to see if the stronger regimen leads to a complete disappearance of the tumor, poten…

This study is checking if a new insulin pump (NMX8) and continuous glucose monitor (DS5/Simplera Sync) are safe for people with type 1 or type 2 diabetes. About 400 participants, ages 7 to 85, will first wear the sensor for up to 40 days, then use the pump for about 90 days while…

This early-phase trial is testing a new treatment called LB1908, which uses a patient's own immune cells (T-cells) that have been modified in the lab to recognize and attack cancer cells that have a protein called claudin 18.2 on their surface. The study includes up to 56 adults …

This phase 1 trial tests FF-10832, a liposomal version of the chemotherapy drug gemcitabine, in adults with advanced solid tumors, including biliary tract cancer, that have not responded to standard treatment or have no standard options. Researchers give the drug as an intravenou…

This Phase 3 trial is testing whether adding an experimental drug called quemliclustat to standard chemotherapy (nab-paclitaxel and gemcitabine) helps people with metastatic pancreatic cancer live longer. About 610 participants who have not yet received treatment for their advanc…

This trial compares two treatment approaches for pancreatic neuroendocrine tumors that have spread or cannot be removed surgically. One group receives lutetium Lu 177 dotatate, a radioactive drug that targets tumor cells, while the other receives a combination of chemotherapy dru…

This phase 1 trial tests an experimental cell therapy called IX001 TCR-T in adults with advanced pancreatic or colorectal cancer that has not responded to at least two standard treatments. The therapy uses a patient's own immune cells, engineered to recognize cancer cells with KR…

This study tests whether adding the experimental drug CTX-009 to standard chemotherapy (paclitaxel) helps adults with advanced bile duct, gallbladder, or ampullary cancer that has worsened after one prior treatment. About 168 participants will be randomly assigned to receive eith…

This trial tests whether adding weekly thermotherapy, a treatment that heats the tumor and lymph nodes, to standard radiotherapy can help people with head and neck cancer who cannot receive chemotherapy. The goal is to find a safe dose of thermotherapy that does not cause severe …

This study tests a new drug called futibatinib combined with standard immunotherapy and chemotherapy in people with advanced esophageal or pancreatic cancer. The goal is to see if the combination can shrink tumors and control the disease. About 53 adults who have not had prior tr…

This early-phase trial is testing a combination of chemotherapy (FOLFOX), an anti-angiogenic drug (bevacizumab), and two immunotherapies (botensilimab and balstilimab) in 20 patients with MSS metastatic colorectal cancer, a type that usually doesn't respond to immunotherapy. The …

This study tests a new oral drug called IPN01194 in 36 adults with advanced solid tumours (melanoma, colorectal, pancreatic, or head and neck cancer) that have not responded to standard treatments. The goal is to find the right dose and check if it is safe, while also looking for…

This study compares standard radiation plus cisplatin against two experimental approaches: radiation with docetaxel and cetuximab, or radiation with cisplatin and the immunotherapy drug atezolizumab. About 613 patients with high-risk stage III-IV head and neck cancer will partici…

This early-stage trial is testing a new oral drug, PF-07799933, in people aged 16 and older with advanced solid tumors that have a specific BRAF gene change. The drug is given alone or combined with other medicines like binimetinib or cetuximab. The study aims to find safe doses …

This study tests the drug tarlatamab in people with advanced tumors that have a protein called DLL3. The goal is to see if the drug can shrink or control these tumors. About 29 adults with stage IV cancer will receive tarlatamab, and researchers will track how well it works and a…

This study investigates whether omega-3 fatty acids, natural fats found in fish and flaxseed, can help manage blood sugar and reduce inflammation in people with type 2 diabetes and heart disease. Participants take omega-3 supplements or a placebo for 28 days, and researchers meas…

This study tests a new drug called elafibranor in people with primary biliary cholangitis (PBC), a rare liver disease that can lead to scarring and liver failure. Participants either did not get enough help from or could not take the standard medicine. The goal is to see if elafi…

This study tests a new drug called BMS-986490, alone or with bevacizumab, in people with advanced solid tumors that have a specific marker (CEACAM5). The goal is to see if the treatment is safe and works against these cancers. About 360 participants will take part in this early-s…

This study looks at whether adding two immunotherapy drugs, nivolumab and ipilimumab, to standard chemotherapy and radiation helps people with esophageal or gastroesophageal junction cancer before and after surgery. About 278 adults with stage II to IVA cancer will take part. The…

This study tests a combination of three drugs (botensilimab, balstilimab, and regorafenib) in people with a type of advanced colorectal cancer that is hard to treat (MSS type) and has worsened after standard chemotherapy. The goal is to see if this mix can shrink tumors or slow t…

This study compares a new insulin that is injected once a week (insulin icodec) to a standard daily insulin (insulin glargine) in about 877 adults with type 1 diabetes. The goal is to see if the weekly insulin controls blood sugar just as well as the daily one. Participants will …

This study tests whether a new drug called zanidatamab, combined with chemotherapy and sometimes another drug (tislelizumab), works better than the current standard treatment for advanced HER2-positive stomach and esophageal cancers. About 920 adults whose cancer has spread or ca…

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes better manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals…

This early-stage trial tests two experimental pills (PF-07799544 and PF-07799933) taken twice daily at home by adults with advanced solid tumors that have a specific gene change called BRAF V600. The study aims to find safe doses and see if the drugs can shrink tumors. About 124 …

This program offers daraxonrasib to adults with metastatic pancreatic cancer that has worsened after prior treatment and who have no other good options. It is for patients who cannot join ongoing clinical trials. The goal is to provide access to this experimental drug when no sta…

This study tests whether giving two immune-calming drugs (rituximab followed by abatacept) can better preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes, compared to rituximab alone. About 74 participants aged 8 to 45 will receive the drug …

This study tests a drug called zolbetuximab that targets a protein (CLDN18.2) found in many stomach and gastroesophageal junction tumors. The drug is given alone or with chemotherapy and/or immunotherapy to see how well it controls tumor growth. The study includes 143 adults with…

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, type 2 diabetes, or high blood pressure. Participants use a tablet, scale, and activity tracker at home, and some get extra support from a co…

This study tests whether guselkumab, given as a shot under the skin, can help people with moderate to severe Crohn's disease achieve remission and heal their gut lining. About 350 adults who have not responded well to other treatments will receive either guselkumab or a placebo. …

This large study tests whether guselkumab, an injected drug, can control symptoms and heal the gut lining in people with moderate to severe Crohn's disease. About 1,400 participants will receive guselkumab, an existing treatment (ustekinumab), or a placebo. The goal is to see if …

This study tests a daily pill called elafibranor in about 18 Japanese adults with primary biliary cholangitis (PBC), a rare liver disease that can lead to scarring and liver failure. Participants had not responded well to standard treatment. The main goal is to see if the drug im…

This study tests guselkumab, a drug that targets inflammation, in over 1,000 people with moderate to severe ulcerative colitis. Participants receive either guselkumab or a placebo to see if the drug can improve symptoms and lead to remission. The goal is to find a new treatment o…

This study is testing a combination of two chemotherapy drugs (gemcitabine and nab-paclitaxel) with a precise type of radiation called proton therapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to find the highest safe dose of…

This study tests a drug called elafibranor in 68 adults with primary sclerosing cholangitis (PSC), a rare liver disease that damages bile ducts. The main goal is to check the drug's safety and side effects compared to a placebo. Researchers will also look at blood tests to see if…

This trial tests whether community pharmacies can run a produce prescription program for adults with type 2 diabetes or hypertension. Participants receive a monthly card loaded with funds to buy healthy foods like fruits, vegetables, beans, nuts, and seafood at their usual grocer…

This study tests whether early, personalized nutritional support and a simple home exercise program can prevent weight loss and improve quality of life in 200 adults with lung, colorectal, ovarian, or pancreatic cancer starting palliative chemotherapy. Participants receive guidan…

This early-phase trial is testing an experimental drug called AB598, alone or with other cancer drugs, in 40 people with advanced solid tumors like lung, bladder, or breast cancer. The main goal is to check safety and find the right dose. It is not yet known if the drug helps shr…

This study tests a drug called MRG003 in adults whose nasopharyngeal cancer has come back or spread and hasn't responded to standard treatments. The goal is to see if the drug can shrink tumors and how safe it is. About 238 participants will receive the drug, and researchers will…

This study tests a combination of three drugs—bintrafusp alfa, PDS01ADC, and entinostat—in adults with advanced HPV-related cancers (like cervical, anal, or throat cancer) or certain colon cancers that haven't responded to standard treatment. The goal is to find a safe dose and s…

This study tests a drug called amlitelimab in adults with celiac disease who still have symptoms even after following a gluten-free diet for at least a year. About 229 participants will receive either the drug or a placebo as a shot under the skin for up to 28 weeks. The goal is …

This study tests a new drug called Cetrelimab (JNJ-63723283) in 234 people with advanced solid tumors like lung, melanoma, bladder, and colorectal cancers. The drug works by blocking PD-1, a protein that stops the immune system from attacking cancer cells. The trial has two parts…

This study compares the real-world effectiveness of mirikizumab against standard biologic therapies for adults with ulcerative colitis or Crohn's disease. Researchers will track whether mirikizumab reduces the need for extra medical care, like emergency visits or treatment change…

This study tests a drug called golimumab in children aged 2-17 with moderate-to-severe ulcerative colitis, a chronic bowel disease causing inflammation and symptoms like diarrhea and bleeding. The goal is to see if the drug can bring about remission (symptom relief) within 6 week…

This study tests a drug called odevixibat in 180 children with biliary atresia, a rare liver disease. The goal is to see if the drug helps children stay alive without needing a liver transplant over the long term. Children who completed a previous study can join this open-label e…

This study tests whether combining new drugs with or without chemotherapy can safely control advanced stomach, GEJ, or esophageal cancer. About 332 adults with inoperable or metastatic disease will receive different treatment combinations. The goal is to find more effective optio…

This trial tests whether dapagliflozin, a drug used for diabetes, can reduce liver fat in people with underactive thyroid (hypothyroidism) who also have non-alcoholic fatty liver disease (NAFLD). Half of the 50 participants will take dapagliflozin daily, and the other half will t…

Researchers are testing whether having mango before or after a meal changes how the body handles blood sugar and inflammation in people with prediabetes. The study involves 33 adults aged 20 to 60 who are overweight and have elevated fasting glucose or HbA1c. Participants will co…

Researchers are testing whether a specially fermented milk drink with probiotic bacteria can improve symptoms of irritable bowel syndrome (IBS) and metabolic syndrome. The study will include 80 adults with IBS or at least one sign of metabolic syndrome, such as high blood pressur…

This trial tests whether a combination of dapagliflozin, saxagliptin, and metformin can help control blood sugar in 600 adults with type 2 diabetes who have controlled cancers. Participants take the drugs by mouth for at least 90 days. Researchers measure blood sugar and insulin …

This trial tests whether adding the immunotherapy drug toripalimab to two different chemotherapy regimens, given before surgery, can help people with locally advanced gastric adenocarcinoma. About 248 adults with HER2-negative stomach cancer will receive either docetaxel, oxalipl…

This trial asks whether a supplement made from brown algae, called fucoidan, can improve gut health in people with mild to moderate ulcerative colitis. Participants will take fucoidan or a placebo alongside their usual medication for 12 weeks. Researchers will measure changes in …

This phase II trial is testing whether a combination of three treatments—QL1706 (an immunotherapy), lenvatinib (a targeted therapy), and GEMOX (two chemotherapy drugs)—can help people with bile duct or gallbladder cancer that cannot be removed by surgery. The study will enroll ab…

This trial asks whether adding maximal tumor debulking—removing or destroying as many metastases as possible through surgery, heat ablation, chemo-embolization, or targeted radiation—to standard chemotherapy improves overall survival in people with colorectal cancer that has spre…

This trial tests whether a prebiotic supplement can ease symptoms in people with mild ulcerative colitis, a chronic inflammatory bowel disease. Participants will take either the prebiotic or a placebo for eight weeks. The study aims to see if certain gut bacteria patterns can pre…

This study tests whether a diabetes care program using continuous glucose monitors (CGM) and remote patient monitoring can help adults with uncontrolled type 2 diabetes improve their blood sugar levels and reduce diabetes-related distress. Participants will wear a CGM that shows …

This phase 2 trial is testing whether adding the immunotherapy drug durvalumab to the usual chemotherapy and radiation treatment can help people with locally advanced anal cancer stay cancer-free longer. The study includes about 180 adults with stage IIB–IIIC anal cancer. Partici…

This clinical trial is testing whether risankizumab, an experimental drug, can safely and effectively maintain remission in people with moderate to severe Crohn's disease who have already responded to initial treatment. Participants will receive either risankizumab or a placebo f…

This phase 3 trial is testing whether adding the immunotherapy drug toripalimab to standard chemotherapy and radiation can improve outcomes for people with locally advanced nasopharyngeal carcinoma, a type of head-and-neck cancer. Participants will receive either toripalimab or a…

This trial tests whether adjusting diabetes medications to keep blood sugar levels in the normal range can preserve the body's insulin-producing beta-cells and slow the natural worsening of type 2 diabetes. Adults aged 40 to 75 with type 2 diabetes will be assigned to either usua…

This trial tests whether giving radiation to a smaller area of the neck can prevent throat cancer from returning while reducing side effects. People with p16-positive oropharynx cancer (a type linked to HPV) who are getting radiation therapy may be eligible. The goal is to see if…

This pilot trial tests whether the timing of carbohydrates and protein across meals can improve glucose metabolism in people with prediabetes or type 2 diabetes who are overweight or obese. Participants follow two different isocaloric diets—one with a high-protein breakfast and h…

This trial is testing whether toripalimab, an immunotherapy drug, can help prevent liver cancer from returning after surgery. Participants are people with hepatocellular carcinoma who have a high risk of recurrence despite having had the tumor completely removed. Half will receiv…

This trial asks whether real-time continuous glucose monitoring (CGM) can improve blood sugar control in adults with type 2 diabetes who do not use insulin. Participants will either use a CGM device or stick to standard self-monitoring with a blood glucose meter. The study tracks…

This trial tests whether providing monthly food vouchers for farmers markets and mailed food stock boxes, alongside diabetes education, can help African American adults with type 2 diabetes and food insecurity achieve better blood sugar control. Participants are randomly assigned…

This trial tests whether proglumide, an older drug that blocks a specific receptor, can safely reduce pain and slow or reverse the scarring seen in chronic pancreatitis. The study includes adults with confirmed chronic pancreatitis and compares proglumide against a placebo over 1…

This early-stage trial is testing an experimental oral drug, TYRA-200, in people with advanced bile duct cancer (intrahepatic cholangiocarcinoma) and other solid tumors that have specific changes in the FGFR2 gene. The study aims to find a safe and effective dose and to see wheth…

This trial is testing whether a catheter that suctions out blood clots can restore blood flow to the intestine in people with acute mesenteric ischemia, a life-threatening blockage of the artery feeding the gut. Participants will undergo thrombus aspiration, and if needed, laparo…

This trial tests whether a low-calorie or low-carbohydrate diet can help people with type 2 diabetes achieve remission—meaning blood sugar returns to normal without medication. One hundred adults aged 20–80 with type 2 diabetes and a BMI of 27 or higher will follow a structured d…

This phase 2 trial is testing whether a combination of trifluridine/tipiracil (Lonsurf) plus oxaliplatin, with or without the immunotherapy nivolumab, can help people with advanced HER2-negative stomach, esophageal, or gastroesophageal junction cancer. The study compares these co…

This study tests whether student pharmacists can help older Asian adults (age 50+) with uncontrolled type 2 diabetes improve their blood sugar through lifestyle coaching, education, and adherence support. Participants will receive non-pharmacological guidance from student pharmac…

This study tests whether a digital platform called Haibu Diabetes helps children with type 1 diabetes manage their condition better. The platform collects health data from devices and shares it with patients, caregivers, and doctors through a single dashboard. Researchers will co…

This phase 3 trial investigates whether bovine colostrum—the nutrient-rich first milk from cows—can improve survival in people with severe alcohol-associated hepatitis. The condition involves liver inflammation, a leaky gut, and a high risk of infection. Participants receive eith…

This study tests whether an experimental drug called D-2570 can help people with moderately to severely active ulcerative colitis achieve remission. About 120 adults will receive either D-2570 or a placebo daily for 12 weeks. The main goal is to see if more people on D-2570 reach…

This trial is for people with advanced cancers who have already responded well to 6 months of standard immunotherapy. It compares continuing the same drugs at the usual frequency versus giving them every 3 months. The goal is to see if the reduced schedule can prevent cancer prog…

This phase II trial tests a personalized strategy for people with resectable esophageal squamous cell carcinoma. Participants first receive a combination of chemotherapy and the immunotherapy drug sugemalimab. Those whose tumors shrink significantly then get radiation plus more i…

This study tests whether semaglutide, a drug already used for obesity and type 2 diabetes, can reduce liver scarring in people with non-alcoholic fatty liver disease (NAFLD). Participants are adults aged 40 to 80 who are overweight or have type 2 diabetes. The trial will also val…

This phase 3 trial tests whether adding bevacizumab (a drug that starves tumors by blocking new blood vessels) to standard maintenance chemotherapy helps people with metastatic colorectal cancer stay progression-free longer. About 400 adults whose disease is controlled after 4–6 …

This study investigates whether adding two common drugs—valsartan (for high blood pressure) and celecoxib (for arthritis pain)—to standard metformin therapy can improve blood sugar control in people with type 2 diabetes. The trial enrolls adults with obesity, high blood pressure,…

This study tests a new type of mesh called Transorb that grips itself in place and dissolves over time, used during open surgery to repair ventral hernias. It focuses on patients with at least one risk factor that impairs wound healing, such as smoking or diabetes. The goal is to…

This trial tests a culturally adapted program called Health Without Barriers/Salud Sin Barreras for teens aged 11–19 and their families in Northern Colorado. The program combines mindfulness, nutrition education, physical activity, and parenting support over several sessions. Res…

This trial compares changing the dressing on a PICC line (a type of central catheter) every week versus every two weeks in people with colon or pancreas cancer receiving chemotherapy. The goal is to see if less frequent changes are just as safe, with no increase in skin injuries,…

This phase 1 trial tests a new method of delivering chemotherapy for people with cancers that have spread to the lining of the abdomen (peritoneal carcinomatosis) from gastrointestinal cancers like colorectal, stomach, or pancreatic cancer. The drug, nanoliposomal irinotecan (Oni…

This study tests whether people with type 2 diabetes who take their usual metformin on the morning of surgery have better blood sugar control and fewer problems like infections. Participants are randomly assigned to receive either metformin or a placebo before their operation. Th…

This study investigates whether SGLT2 inhibitors, a class of diabetes medications, can slow cognitive decline in people aged 50 and older with type 2 diabetes. Participants are randomly assigned to receive either standard diabetes care plus an SGLT2 inhibitor (empagliflozin or da…

This study tests whether taking agave inulin, a natural fiber, for eight weeks can improve blood sugar control and increase healthy gut bacteria in adults with type 2 diabetes. Participants receive either 10 grams of agave inulin or a placebo daily. Researchers measure changes in…

This trial tests a digital tool that helps doctors and patients manage cancer risks linked to hereditary syndromes like BRCA-related breast/ovarian cancer and Lynch syndrome. The tool provides personalized recommendations during primary care visits. Researchers compare care gaps,…

This trial tests whether giving chemotherapy before or after radiation therapy works better for people with locally advanced rectal cancer that has a high risk of coming back. Participants receive the same drugs (capecitabine and oxaliplatin) but in a different order. The goal is…

Researchers are testing whether a brain imaging measurement can predict how strongly the body reacts to low blood sugar. The study enrolls healthy adults aged 18 to 40 with a body mass index between 20 and 30. Participants undergo two procedures: a brain scan to measure glial ace…

Researchers test whether flushing the biopsy needle with heparin, a blood thinner, helps collect more and better tissue from solid abdominal tumors during endoscopic ultrasound-guided fine needle biopsy. They also test whether using a microsieve to prepare the tissue improves the…

Researchers are studying whether they can predict which patients having routine gallbladder removal for gallstones or related problems might have unsuspected gallbladder cancer. They plan to collect data from up to 30,000 adults and use risk factors to build a scoring system. The…

Functional somatic disorders cause persistent physical symptoms that doctors cannot explain by other diseases. The DISTRESS trial evaluates a new clinic where internal medicine doctors, trained to recognize these disorders, examine patients and provide guidance to their general p…

Pancreatic neuroendocrine tumors behave unpredictably: some stay slow for years while others spread quickly, and doctors lack reliable tests to tell them apart before surgery. This study examines cell-free DNA, tiny genetic fragments shed by tumors into the bloodstream, from abou…

This study tests a new way to screen for type 2 diabetes by measuring sugar levels in fingernails. Researchers will compare results from 100 adults (half with known diabetes, half without) to standard blood tests. The goal is to see if this simple, non-invasive method can accurat…

This study tests an AI tool called LEAF that helps doctors analyze CT scans of the abdomen to find liver cancer early. Researchers will use scans from 10,000 patients with confirmed liver tumors to train the AI to better detect cancer. The goal is to improve early screening and g…

This study tests whether a low-radiation CT scan, enhanced with artificial intelligence software, can detect liver tumors as accurately as a standard CT scan. About 146 adults with colorectal cancer and known liver metastases will receive both scans. The goal is to see if the low…

This early-stage trial tests a radioactive imaging agent called RAD301 in 9 people: healthy volunteers and patients with pancreatic, lung, esophageal, cervical, endometrial, or ovarian cancer. The goal is to see how safe it is and how it travels through the body. If it works, it …

Researchers are testing a blood test panel called Glycotest HCC to see if it detects early-stage liver cancer better than the standard alpha-fetoprotein (AFP) test. The study includes 766 people with cirrhosis, some of whom have early liver cancer and some who do not. Participant…

Radiation teams use cone beam CT scans to line up patients with the treatment beam, but standard images are not clear enough to map tumors or calculate doses. This study tests whether a new imaging system called HyperSight, built into the TrueBeam radiotherapy machine, can produc…

Researchers are testing an experimental imaging agent called MNPR-101-DFO*-89Zr in people with several types of solid tumors, including bladder, breast, lung, and pancreatic cancers. The agent combines an antibody with a radioactive label, which may help PET scans reveal where tu…

This early-phase trial at Memorial Sloan Kettering is testing whether a special PET scan using an experimental tracer called 18F-FAC can show how much of the standard chemotherapy drug gemcitabine is taken up by pancreatic tumors. About 30 people with pancreatic ductal adenocarci…

This study is testing a mixed meal test to better diagnose a specific type of diabetes (type 3c) that occurs in people with pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 84 who have new-onset diabetes and one of these pancreatic conditio…

This study tests a new platform called xDRIVE that combines drug sensitivity testing and AI to predict which treatments will work best for people with advanced colorectal cancer. The platform will not provide treatment itself but will give doctors a recommendation. The goal is to…

Researchers are testing whether a blood test that looks at DNA methylation patterns can find nasopharyngeal carcinoma earlier and more accurately than the standard Epstein-Barr virus (EBV) tests. The study will compare the new multi-omics model with EBV DNA quantification and two…

This study tests whether combining artificial intelligence with blood biomarkers can improve the detection of compensated advanced chronic liver disease (cACLD) in people with fatty liver disease. Researchers will enroll 408 adults with dysmetabolic liver disease and compare stan…

This study tests whether two imaging tools—laser speckle contrast imaging (LSCI) and digital thermography—can objectively grade mesenteric traction syndrome (MTS), a frequent complication during abdominal surgery that causes low blood pressure, rapid heart rate, and facial flushi…

This trial is testing a blood test that looks for DNA markers of liver cancer in people with liver cirrhosis, who are at high risk for developing the disease. The test is compared to standard ultrasound to see which method is better at detecting liver cancer. If the blood test pr…

This study explores whether a community-based cooking program can help African-American adults at risk for heart disease cook and eat healthier. About 43 participants from Washington, D.C. will take surveys, attend cooking classes led by a chef, and track their eating habits. The…

This study tests different programs to help people at high risk for cancer (such as those with BRCA or Lynch syndrome) or cancer survivors increase their physical activity and eat healthier. The goal is to see which programs work best to reduce cancer risk. About 337 participants…

Women who develop gestational diabetes are far more likely than other women to develop type 2 diabetes within a few years after giving birth. This trial tests whether a smartphone app that delivers personalized coaching on diet, exercise, sleep, and mental well-being can help pre…

This study tests whether curcumin, a compound found in turmeric, can prevent stomach cancer in people with chronic atrophic gastritis or gastric intestinal metaplasia. About 50 participants will receive either curcumin or a placebo for a period, and researchers will measure chang…

This study tests whether the nine-valent HPV vaccine can prevent long-lasting oral HPV infections in men who have HIV. About 700 men will receive either the vaccine or a placebo. The goal is to see if the vaccine reduces new persistent infections with HPV types linked to throat c…

Researchers are testing an experimental vaccine called Ad5.F35-hGCC-PADRE in adults who have had surgery and standard treatment for gastrointestinal cancers, including pancreatic, colorectal, esophageal, gastric, and small bowel adenocarcinomas. The trial aims to find a safe dose…

Researchers at Cornell University are testing whether a produce prescription program helps adults who have diet-related conditions and trouble affording food. Participants receive weekly boxes of fresh local produce for 8 to 24 weeks and attend eight nutrition education classes. …

This study tests an experimental drug called LMN-201 to see if it can prevent C. difficile infection from coming back after standard antibiotic treatment. About 375 adults with a recent C. diff infection will receive either LMN-201 or a placebo. The main goal is to see if more pe…

Researchers are testing whether a gluten-free diet during the first three years of life, or daily probiotic supplements, can prevent celiac disease in children with a high genetic risk. The trial enrolls infants before they start eating gluten and randomly assigns them to one of …

This study tests whether the anti-inflammatory drug sulindac can prevent high-risk pancreatic cysts (IPMNs) from progressing to pancreatic cancer. About 100 adults with these cysts will receive either sulindac or a placebo for up to 3 years, alongside standard monitoring. The goa…

This large study compares two common colorectal cancer screening methods: colonoscopy and annual fecal immunochemical testing (FIT). Over 50,000 veterans aged 50-75 will be randomly assigned to one of the two screenings and followed for 10 years. The goal is to see which approach…

This trial tests whether an annual stool-based test (FIT) can be as effective as routine colonoscopy for people who have had advanced polyps removed. Participants aged 50 to 65 from colorectal cancer screening programs will be randomly assigned to either yearly FIT or scheduled e…

This study tests whether screening children with a high genetic risk for type 1 diabetes, along with regular follow-up and family education, leads to an earlier diagnosis of the disease. Researchers will track 600 children to see if this approach prevents severe symptoms and diab…

This study tests whether sending personalized screening invitations based on a person's race, ethnicity, and diabetes risk, plus offering phone navigation for those who don't respond, leads to more people getting tested for diabetes compared to generic invitations or usual care. …

This trial tests whether adding a real-time continuous glucose monitor (CGM) to a YMCA healthy lifestyle program helps adults with prediabetes improve their glucose levels, diet, and physical activity. Participants attend health coaching sessions and YMCA classes, with some weari…

This trial tests whether giving women who had gestational diabetes a continuous glucose monitor and a FitBit can help them adopt healthier habits and prevent type 2 diabetes. Participants will wear the sensor for up to 14 days and use the tracker to monitor their activity. The st…

This trial tests whether adding recreational basketball to the standard National Diabetes Prevention Program (NDPP) helps adults aged 18-44 with prediabetes lose more weight, lower blood sugar, and become more active. Participants are randomly assigned to either the standard prog…

This study looks at whether massage therapy can reduce nerve problems like pain, numbness, and tingling caused by chemotherapy in people with breast or digestive system cancers. About 90 participants will receive massage sessions to see if it improves symptoms and quality of life…

Doctors remove right or left colon cancer along with nearby lymph nodes, but the deep nerves that control the gut often get damaged. That damage can leave patients with lasting diarrhea, bowel spasms, or slow bowel movements. This trial compares standard surgery with a laparoscop…

During laparoscopic surgery on the rectum or lower sigmoid colon, the small intestine can slip into the operating area and block the surgeon's view. This trial tests a disposable isolation device that holds the small intestine away from the surgical site. Researchers compare the …

Researchers are testing whether an enhanced web-based health education program helps people with hepatocellular carcinoma (liver cancer) improve their self-care and quality of life while undergoing transarterial chemoembolization (TACE). The trial enrolls 252 adults scheduled for…

This pilot study offers free legal services to caregivers and patients dealing with advanced colorectal cancer. The goal is to see if early legal support can reduce financial and emotional stress. Twenty patient-caregiver pairs will receive personalized legal help from a nonprofi…

This study tests an injected drug called Halneuron to see if it can safely reduce nerve pain caused by chemotherapy. About 240 adults who have nerve pain from platinum or taxane chemo will receive either Halneuron or a placebo shot. The goal is to measure pain relief, sleep, fati…

This early-phase study tests whether a liver cancer treatment called Y90 radioembolization can be safely done in a single session instead of the usual two-day process. The treatment uses tiny radioactive beads injected into the liver's blood supply to block tumor growth. Research…

Researchers test whether repeated cold exposure using a water-perfused cooling suit can reduce liver fat and improve liver health in adults with metabolic dysfunction-associated steatohepatitis (MASH). Eleven participants wear the suit for about two hours daily over three months.…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This early-phase study tests an oral drug called ropidoxuridine (IPdR) in people with advanced gastrointestinal cancers that cannot be cured. The goal is to find the safest dose and see if it can make radiation therapy more effective at shrinking tumors. Nineteen participants wit…

This pilot study tests MPowerHub, a smartphone app that helps adults with type 2 diabetes make sense of data from continuous glucose monitors and activity trackers. The app shows combined trends and prompts daily questions about diet, sleep, stress, and medication. Researchers wa…

This trial compares two ways to control pain after open liver surgery: an epidural pump that delivers pain medicine near the spine, versus a standard IV pump. About 230 adults having elective open liver resection will be randomly assigned to one method. The goal is to see which a…

This study tests a program of exercise, protein drinks, and mind-body activities like yoga for people aged 65 and older with advanced ovarian or pancreatic cancer. The goal is to see if patients can stick with the program while on chemotherapy before surgery. The study is small, …

This study tests whether ebastine, an allergy medication, works better than mebeverine, a common IBS drug, for reducing belly pain and improving daily life. About 200 adults with non-constipated IBS will take one of the two pills for 12 weeks. The goal is to see if ebastine provi…

This study tests whether adding mental health care to standard diabetes treatment improves mood and blood sugar control in adults with type 1 diabetes. Eighty participants will be randomly assigned to usual care or a collaborative care model that includes a behavioral health cons…

This study looks at whether treating insomnia can help people with Crohn's disease feel better, including reducing pain and inflammation. About 83 adults with mild to moderate Crohn's and insomnia will receive a remote sleep treatment. The main goal is to see if the approach is p…

Researchers are testing a virtual stress-management program for people who care for a spouse or partner with a solid tumor cancer while also holding a job. The program teaches skills such as paced respiration, relaxation, and coping with work and caregiving demands across eight s…

This study tests a proprietary amino acid drink given twice daily for up to 4 days to older adults (60+) hospitalized with infections who have delirium. 20 participants get the drink, 20 get standard care, and 20 non-delirious controls are observed. The goal is to see if the drin…

Researchers test an 8-week online precision nursing education program for young colorectal cancer survivors. The program includes Qigong exercise and mindfulness training delivered through an e-flipped classroom model. The study measures changes in depression symptoms and mindful…

This study looks at whether a special stent (Hot AXIOS) can improve quality of life for people with bile duct blockages caused by cancer, when standard drainage fails. About 162 adults will receive the stent during an endoscopic procedure. The main goal is to see if jaundice symp…

This study tests a program that combines pelvic floor physical therapy with coping skills training to help women who have had pelvic radiation for cancer. The goal is to improve sexual function and quality of life. The study involves 12 cancer survivors and focuses on whether the…

This study compares high-effort versus low-effort resistance exercise sessions to see which better controls blood sugar in people with prediabetes or type 2 diabetes. Fifteen participants will complete both types of sessions plus a no-exercise control day, with blood sugar monito…

This study tests a new augmented reality system called LUMENA that helps doctors guide needles during MRI scans of the liver. Twenty adults having a liver biopsy or tumor ablation will try the device. The goal is to see if it is safe and works well enough to use in most procedure…

This study explores whether physical activity and fitness can reduce inflammation and improve quality of life in children aged 6 to 17 with Crohn's disease or ulcerative colitis. Researchers will track 100 participants over time and test a 12-week supervised exercise program. The…

This study is testing whether a device that delivers mild electrical stimulation through the skin (called TEA) can help with chronic pain and depression in people with cirrhosis. Thirty participants will use the device at home twice daily for 8 weeks, or a sham version. The main …

This study looks at the long-term safety and effectiveness of odevixibat in 70 people with Alagille syndrome, a rare genetic condition that affects the liver and other organs. The drug aims to reduce severe itching and improve bile flow. Participants who completed a prior 24-week…

This trial tests whether people with mild diverticulitis can be safely treated at home with just pain medicines (ibuprofen and acetaminophen) instead of antibiotics. 556 participants will be randomly assigned to receive either pain medicines alone or pain medicines plus an antibi…

This study looks at how dried figs affect blood sugar and insulin in adults with pre-diabetes. Five participants will eat figs or a calorie-matched control breakfast, and researchers will measure blood glucose, insulin, and fig polyphenol levels over 24 hours. The goal is to see …

This pilot study tests a mobile phone program called STRIDE for adults with type 2 diabetes and a close friend or family member. The program includes monthly coaching calls and text message support to help with medication and goals. The study will enroll 180 people to see if the …

This pilot study tests a training program designed to improve eHealth literacy—the ability to find and use health information online—among Bangladeshi adults with type 2 diabetes in Ancona, Italy. The program, co-designed with patients and community members, includes four modules…

This trial asks whether an opioid-free anesthesia method can control acute pain after laparoscopic colorectal surgery as well as or better than standard opioid-based anesthesia. Adults aged 18 to 90 scheduled for this surgery will be randomly assigned to receive either a combinat…

This trial tests whether tocilizumab, an anti-inflammatory drug used for arthritis, can reduce pain and improve quality of life in people with chronic pancreatitis. Participants receive either tocilizumab or a placebo every four weeks for 24 weeks. The study measures changes in p…

This trial tests whether giving older adults with diabetes and other chronic conditions audio recordings of their clinic visits helps them take a more active role in their own care. Participants either receive these recordings for a year or standard after-visit summaries. The stu…

This study tests whether a supervised, home-based exercise program can help people with metastatic cancer who are starting oral targeted therapy. Participants are randomly assigned to either a weekly 60-minute session with a trained coach or to a booklet with exercise recommendat…

This trial tests whether plecanatide, a drug taken by mouth once a day, can safely improve bowel movements in children and adolescents aged 6 to 17 with functional constipation. Participants receive either low-dose plecanatide, high-dose plecanatide, or a placebo for 8 weeks. The…

This study compares two different footstool heights (7 inches vs. 9 inches) to see if using one during bowel movements can reduce straining and improve the feeling of complete emptying in people with pelvic floor dysfunction and chronic constipation. Participants use the footstoo…

This study tests whether a tailored exercise program and nutritional guidance can reduce peripheral neuropathy (nerve damage) and fatigue in people with colorectal cancer receiving chemotherapy. Participants follow a supervised exercise routine and monthly nutrition check-ins dur…

This trial tests Gelclair, a mouth rinse that forms a protective coating over the mouth's lining, to see if it eases the painful mouth sores (oral mucositis) caused by radiation therapy for head and neck cancer. The study enrolls adults with squamous cell carcinoma who will recei…

This trial tests whether removing the urinary catheter immediately after colorectal cancer surgery (before anesthesia wears off) is as safe and effective as removing it the next day. The goal is to lower the risk of urinary tract infections and help patients recover faster. About…

This study looks at tiny pieces of cancer cells or DNA floating in the blood of people with rectal cancer. Researchers want to see if these markers can help predict how the tumor responds to standard treatment. About 341 participants, including healthy volunteers, will provide bl…

Researchers are building a large bank of blood and stool samples from people with advanced lung, breast, colorectal, and pancreatic cancers, plus healthy volunteers. The goal is to learn whether the mix of bacteria in a person's gut can predict how well cancer treatment works and…

This study tests a new program designed to help head and neck cancer patients who feel depressed. The goal is to see if the program is practical and liked by patients, and if it can improve their mood and help them follow through with swallowing exercises and dental care. About 1…

This study follows over 64,000 adults who grew up on farms to see if early exposure to pesticides and other agricultural factors is linked to cancer. Participants fill out an online questionnaire and may provide biological samples. Researchers will track their health over many ye…

This study reviews medical records of 72 American Indian patients treated with immunotherapy for cancers like lung cancer, melanoma, and kidney cancer. Researchers compare their outcomes—such as how long the cancer is controlled and side effects—to those of White patients. The go…

This study is looking for biological markers (biomarkers) that might predict how well patients with certain types of squamous cell carcinoma respond to a type of immunotherapy called PD-1 inhibitors. Researchers will analyze blood and tumor tissue samples from 800 patients, both …

Researchers are building a bank of blood, urine, and stool samples from 100 adults with non-small-cell lung or colorectal cancer who are receiving checkpoint inhibitor immunotherapy. Over 12 months, participants provide five samples of each type. The goal is to study how the body…

This study checks if a Turkish version of a questionnaire about managing low blood sugar (hypoglycemia) is accurate and reliable. Researchers will ask 200 adults with type 2 diabetes who have had low blood sugar to fill out the questionnaire. The goal is to make sure the scale wo…

This early-stage study looks at how taking a new tablet called CX11 with or without food changes the amount of drug in the blood. It involves 32 healthy adults and does not aim to treat any disease. The results will help researchers decide how to give the drug in future studies f…

This pilot study is testing whether wearable activity trackers, like fitness watches, can help monitor fatigue in people with pancreatic or breast cancer who are undergoing treatment. Researchers want to see if patients will use the device daily and find it easy to use. The study…

This study looks at how Western habits—like drinking alcohol and eating late—might raise the risk of colorectal cancer. Twelve adults who have had colon polyps in the past will try four different weekly routines, including eating at normal times or late, with or without alcohol. …

This study follows up to 1,000 adults who previously received gene therapy in a National Cancer Institute study. Researchers will contact participants yearly for up to 15 years to check for any long-term side effects, such as new cancers or nerve problems. No new treatments are g…

This study is looking at how nerve pain (neuropathic pain) affects the ability to care for oneself and overall quality of life in people with type 2 diabetes. Researchers will measure pain levels and quality of life in 128 adults with type 2 diabetes. The goal is to better unders…

This study looks at the genetic and molecular factors behind type 2 diabetes, obesity, and related complications like kidney disease. Researchers will collect health information, blood and urine samples, and perform tests like eye exams and ultrasounds from over 2,300 adults, foc…

This study tests whether a special catheter (TriNav) helps deliver radiation more accurately to liver tumors. About 19 adults with liver cancer that cannot be removed by surgery will receive a test dose followed by the actual treatment. The goal is to see if the two doses match b…

This study is testing whether regular screening for prostate, lung, colorectal, and ovarian cancers can reduce deaths from these diseases. About 154,900 men and women aged 55-74 were randomly assigned to either get screened or receive usual care. Researchers are tracking cancer c…

This study looks at whether a website and a genetic family navigator can help more relatives of people with hereditary cancer get genetic testing. About 205 participants will use the online hub and work with a navigator to learn about their cancer risk. The goal is to see if this…

This long-term study follows over 3,700 adults in Baltimore to understand why some people age healthier than others. Researchers are looking at how race, income, and neighborhood affect risks for diseases like diabetes, heart disease, and memory loss. Participants visit mobile he…

This pilot study is testing a device called LabClasp that measures blood sugar without needles. Researchers want to see if regular, non-invasive glucose checks can help predict gestational diabetes and preeclampsia in pregnant women. The study plans to enroll 100 women with at le…

This study follows 500 obese adults to see how different factors like diet, exercise, stress, and sleep affect weight loss. Researchers collect blood tests, measurements, and questionnaires at the start and during follow-up. The goal is to find patterns that could lead to more pe…

Primary biliary cholangitis is a rare liver disease that slowly damages the bile ducts and can lead to cirrhosis or a liver transplant. Researchers are studying anonymised health records from about 3,000 adults in four Spanish databases to estimate how many people have the diseas…

This study collects health information and test results from 317 people at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. Researchers aim to build a database to find better ways to detect the disease early or prevent it. No …

Researchers at Cincinnati Children's Hospital are studying whether adding violet and blue wavelengths to the lighting in a neonatal intensive care unit changes how premature infants use the nutrition they receive. The study includes 32 infants born at 32 weeks or later who are ex…

This study aimed to evaluate how community cancer centers test for biomarkers in common solid cancers like breast, lung, and colorectal cancer. Researchers planned to survey pathology practices to see if they follow guidelines for key tests and how quickly results are reported. T…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study investigates why brown fat, which burns calories to generate heat, stops working when it's warm. Researchers will use cold vests on 8 healthy and obese adults to see how genes and proteins change. The goal is to find new targets for treating obesity and related metabol…

Researchers are testing a coaching program to help primary care clinics in rural West Virginia screen and treat opioid use disorder, HIV, and hepatitis C. The program includes group priority-setting, rapid-cycle improvement coaching, and provider training. Twenty clinics will tak…

Researchers at Boston Children's Hospital are studying how the immune system reacts after a single oral dose of gluten powder. The study includes people with celiac disease and healthy controls, all of whom follow a gluten-free diet before the test. By measuring blood levels of i…

This study tests a web-based education tool called HOPE-Genomics that teaches cancer patients about their genetic test results. About 465 adults with breast, colorectal, lung, ovarian, pancreatic, or prostate cancer are taking part. The goal is to see if the tool helps patients r…

This study talks to people living with HIV from diverse backgrounds to learn what helps or hinders them from getting oral health care and cancer prevention. Researchers will hold focus groups and use questionnaires to understand barriers and gather ideas for improvement. The goal…

Researchers are testing a transition program for 17-year-olds with type 1 diabetes, asthma, or obesity who are preparing to move from pediatric to adult healthcare. The program includes a consultation with the teen and family, a solo visit where the teen completes a readiness che…

This study aims to understand how genes affect obesity, diabetes, and heart disease in people of African ancestry. Researchers will collect blood samples and health information from 1,100 adults, including African Americans, Afro-Caribbeans, and migrants from sub-Saharan Africa. …

This study looks at frailty—symptoms like weight loss, weakness, and low activity—in 100 gastrointestinal cancer patients from rural and urban areas before major surgery. Researchers will use a survey, blood sample, and medical records to see if frailty affects recovery. The goal…

This study tests an expanded web-based decision aid for people with cholangiocarcinoma, colorectal cancer, or multiple myeloma. Participants use the tool to choose which genomic results—such as cancer biomarkers or inherited risks—they want to receive. The goal is to see if the t…

This large study is looking at the genes of over 9,000 people with diabetes and kidney disease, along with their family members. The goal is to find which genes make some people more likely to get diabetic kidney disease. By understanding the genetic roots, researchers hope to de…

This pilot study is testing whether it's possible to run a larger study that focuses on heart disease in women. Researchers will gather information from 176 women aged 25-55 in Ontario who have had certain female-specific health issues like pre-eclampsia, gestational diabetes, or…

Researchers are studying whether a mother's weight and blood sugar during pregnancy affect the makeup of her breast milk, and whether those differences influence how her baby grows. The study will follow pregnant women with a range of body sizes, including those with gestational …

This study follows 121 adults who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring or cancer. Participants are monitored for up to 10 years with regular tests, scans, and occasional liver biopsies. The goal is to learn …

This large study is testing whether a risk-scoring tool (called ENDPAC) can identify people with new-onset diabetes who are at higher risk for pancreatic cancer. About 8,800 participants aged 50-85 will have their medical records checked for age, weight changes, and blood sugar t…

This study watches how force feedback instruments work during robot-assisted surgeries with the da Vinci 5 system. About 200 adults having hernia, colorectal, thoracic, gynecologic, or partial kidney removal surgery will take part. The goal is to see how these tools help surgeons…

This study enrolls 400 adolescents and young adults (ages 18-39) recently diagnosed with various cancers. Participants are randomly assigned to either choose which health-related questions they answer or receive a fixed set of questions. The goal is to see if giving patients a ch…

This study monitors heart rate variability in 150 adults with type 2 diabetes who also have heart failure, chronic kidney disease, or both. Participants will wear a 24-hour heart monitor before and after starting a standard SGLT2 inhibitor medication. The goal is to understand ho…

This study gives 20 healthy adults drinks containing sucrose (table sugar), glucose, fructose, or plain water, then measures how their bodies respond. Researchers track gut hormones, blood sugar, digestion speed, and other health markers. The goal is to understand the unique effe…

This pilot study tests a digital tool that doctors use during visits to help patients with prediabetes become more active in managing their health. The tool asks patients a few questions and then gives the doctor tips on how to talk about lifestyle changes and resources like heal…

This study follows 5,000 people with diabetes who use a Dexcom continuous glucose monitoring (CGM) system in their daily routine. Researchers will track how the device performs when used as labeled and ask participants to complete questionnaires over four years. The goal is to un…

This study looks at a rare liver disease called PFIC, which causes severe itching and liver damage. Researchers compare patients who took the drug odevixibat to those who did not, using data from past studies and a patient registry. The goal is to see if odevixibat helps avoid li…

This study tests whether a clinical decision framework helps hospital doctors feel more confident when prescribing medications for older adults (65+) with chronic conditions like diabetes and high blood pressure. About 150 doctors will attend an educational session and complete s…

Researchers at the University of Aberdeen are studying how the community of microbes in the gut, known as the gut microbiota, differs in people with liver disease compared to healthy controls. The liver receives blood from the gut, and changes in gut microbes may affect liver fun…

Researchers at Amsterdam UMC are studying tumor samples from 180 people with advanced melanoma or pancreatic cancer that has stopped responding to immunotherapy. Participants give one extra tumor biopsy and a blood sample. The team will analyze the tumor's full genetic code and t…

This study compares breath gases and gut bacteria between children with functional constipation and healthy children. Researchers measure exhaled nitric oxide, hydrogen sulfide, hydrogen, and methane, and analyze stool samples for microbiome composition. The goal is to see if bre…

This study looks back at dental implant cases to see if bone-related conditions—like vitamin D deficiency, calcium problems, or kidney disease—make implant failure more likely. Researchers will compare 192 failed implants with successful ones from similar patients. The goal is to…

This study looks at whether diabetic kidney disease and blood-sugar control before surgery can help predict a common complication called pseudophakic macular edema (PME) — swelling of the central retina — after cataract surgery in people with type 2 diabetes. Researchers will rev…

This pilot study is testing whether a simple blood test can detect tiny amounts of tumor DNA (ctDNA) in patients with early-stage colorectal cancer before and after surgery. The goal is to see if this test is practical and reliable for spotting any cancer cells left behind, which…

This registry study is collecting blood samples and health data from 1,000 people being evaluated for prostate cancer. The goal is to test the accuracy of a new blood-based test called PROSTest, which looks for genetic signals of prostate cancer activity. Researchers hope this te…

This study investigates whether head and neck cancers caused by HPV have different genetic profiles compared to those linked to alcohol and tobacco use. By analyzing tumor biopsies, researchers aim to identify genetic markers that could predict how well a patient responds to chem…

This study gathers real-world information from pregnant women with type 1 diabetes in the United States to understand how they manage their condition. Participants share data from their continuous glucose monitors and insulin pumps, and complete online surveys. The goal is to lea…

This study investigates whether people with type 2 diabetes who have or are at risk for chronic kidney disease produce too much aldosterone, a hormone that regulates salt and blood pressure. Participants undergo several suppression tests—including oral sodium, saline infusion, an…

This study is testing whether a ketone supplement called beta-hydroxybutyrate (BHB) is safe and tolerable for people scheduled for a colonoscopy or flexible sigmoidoscopy as part of their standard care. Participants will take a drink containing R-1,3-butanediol three times daily …

This study compares over 1,500 people living with HIV to a similar group from the general population to see if conditions like heart disease, COPD, and liver disease are more common or develop faster in those with HIV. Using detailed scans and tests, researchers will measure the …

This study looks at how the immune system's T cells respond to two common herpesviruses—cytomegalovirus (CMV) and varicella-zoster virus (VZV)—in people who have had a liver transplant. Because transplant recipients take drugs that suppress their immune system to prevent organ re…

This study tests whether a standard nutrition screening tool, called PYMS, can accurately identify children with Crohn's disease or ulcerative colitis who are at risk of malnutrition. Researchers will use the tool on 2,000 children aged 4–18 with IBD in outpatient and inpatient c…

This study looks back at the records of about 800 adults who had minimally invasive liver surgery (laparoscopic, robotic, or hybrid) at specialized Italian centers. The goal is to see how the choice of surgical tools and techniques for cutting liver tissue relates to the risk of …

This study looks at people with eosinophilic esophagitis whose symptoms like trouble swallowing or chest pain continue even though their inflammation is under control. Researchers will use special tools to measure how stretchy the esophagus is and how it moves, and also consider …

This study follows people newly diagnosed with Crohn's disease for up to five years to see how the condition damages the bowel over time. Researchers will use imaging scans and other tests to track disease progression and understand how different treatments affect long-term outco…

This study follows about 400 adults with liver cirrhosis admitted to internal medicine wards across Italy. Researchers will track how doctors manage hepatic encephalopathy—a brain complication of liver disease—during hospitalization and after discharge. The goal is to identify pr…

This study is testing whether a simple stool test can predict if the gut lining is healing in people with moderate-to-severe ulcerative colitis who are starting biologic therapy for the first time. Researchers will measure levels of a protein called calprotectin in stool samples …

This observational study follows 200 adults with gastroesophageal reflux disease (GERD) who are scheduled for antireflux surgery in Poland. Researchers collect data on surgical techniques, symptom relief, quality of life, and complications over 12 months. The goal is to identify …

This study follows people with liver cancer who are scheduled for surgery, measuring tiny molecules called microRNAs in their blood before and after the operation. The goal is to find patterns that could signal whether the cancer has come back. Researchers will also look at gut b…

This trial compares two ways of delivering mechanical ventilation—volume-controlled and pressure-controlled—in adults undergoing laparoscopic gallbladder removal under general anesthesia. The goal is to see which mode better maintains lung flexibility and removes carbon dioxide d…

This study looks back at 371 adults who received a living donor liver transplant for hepatocellular carcinoma (a type of liver cancer) to see whether receiving a liver from a donor with an incompatible blood type affects long-term survival or cancer recurrence. Researchers compar…

This registry tracks adults with metastatic colorectal cancer who are starting their first systemic therapy. Researchers will collect information on the treatments doctors choose, how well they work, and patients' quality of life. The goal is to understand what happens in everyda…

This study looks at how chronic noncommunicable diseases like inflammatory bowel disease and breast cancer impact a person's ability to work. Researchers will follow 200 working-age adults for 12 months, collecting data on health, work performance, and well-being. The goal is to …