Antibiotics may not be needed for mild diverticulitis, new US trial suggests
NCT ID NCT07625267
First seen Jun 26, 2026 · Last updated Sep 01, 2026 · Updated 3 times
Summary
This trial tests whether people with mild diverticulitis can be safely treated at home with just pain medicines (ibuprofen and acetaminophen) instead of antibiotics. 556 participants will be randomly assigned to receive either pain medicines alone or pain medicines plus an antibiotic for 7 days. The study will compare hospital admission rates and other complications between the two groups.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ibuprofen and acetaminophen
- What this could lead to
- If this trial succeeds, it could show that many people with mild diverticulitis can avoid antibiotics and still recover safely at home.
- What could go wrong
- This is a Phase 4 trial, but it has not yet started recruiting. The results may not apply to everyone, and some people might still need antibiotics if symptoms worsen.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Expected to start
-
Jul 2026
An estimate. Start dates often move.
- Expected to finish
-
Jun 2028
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Left-sided diverticulitis, primary or recurrent * Signs of diverticulitis on CT-confirmed Hinchey (0 or 1a based on CT final report) * White Blood Cell (WBC) count \<15,000mm\^3 * Controlled symptoms in the ED (i.e., Pain score \<5 on VAS scale, tolerating PO intake, no fever) Exclusion Criteria: * Signs of complicated diverticulitis on CT with abscess, fistula, free air, Micro perforation, or signs of other diagnosis on CT Abdomen and pelvis * Inflammatory bowel disease * American Society for Anesthesiologists (ASA) physical status classification of \>=3 * Immunocompromised patient; (i.e., haematological malignancies, AIDS patients with low CD4+ counts, transplantation, chemotherapy, splenectomy, long-term corticosteroid use and genetic disorders such as severe combined immunodeficiency * Pregnancy * Ongoing antibiotic therapy or in the previous 2 weeks * High fever, affected general condition, peritonitis or sepsis * Subjects who do not have the capacity to consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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