Liver tissue flap tested as alternative seal for burst ulcers
NCT ID NCT07813780
First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time
Summary
Perforated peptic ulcers need urgent surgery. The usual minimally invasive repair uses a piece of the omentum to patch the hole, but that tissue is sometimes scarred or unavailable. This trial randomly assigns adults with small perforations to either the standard omental patch or a flap made from the falciform ligament, a fold of tissue near the liver. Researchers compare how often the repair leaks within 30 days, along with operative time, pain, hospital stay, and ulcer healing.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Laparoscopic falciform ligament flap repair
- What this could lead to
- If the falciform ligament flap works as well as or better than the omental patch, it could offer surgeons another option when the omentum is scarred or unavailable.
- What could go wrong
- This is a small, single-center trial. The flap may not seal the ulcer as reliably as the standard patch, and results may not apply to larger or more complex perforations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients aged 18 years or older, of either biological sex. * Intra-operative diagnosis of a perforated gastric or duodenal peptic ulcer. * Perforation size ≤ 2 cm, judged suitable for closure with a patch technique rather than resection. * Hemodynamically stable enough to tolerate pneumoperitoneum and general anesthesia (American Society of Anesthesiologists \[ASA\] class I-III). * Presentation within 24 hours of onset of symptoms, or beyond 24 hours provided the patient remains a safe candidate for laparoscopy. * Patient (or legal guardian, where applicable) willing and able to provide written informed consent. Exclusion Criteria: * Perforation size \> 2 cm, or intra-operative findings requiring gastrectomy, duodenal exclusion, or other resectional surgery. * Suspicion or histopathological confirmation of a malignant gastric ulcer. * Generalized fecal or severe purulent peritonitis with septic shock or hemodynamic instability precluding a laparoscopic approach. * Severe cardiopulmonary disease or other contraindication to general anesthesia or pneumoperitoneum (ASA class IV-V). * Previous upper abdominal or hepatobiliary surgery that has excised or rendered the falciform ligament unavailable, or that precludes safe laparoscopic access. * Pregnancy. * Uncorrected coagulopathy. * Refusal of consent, or inability to comply with the planned post-operative follow-up schedule.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.