Cardiovascular disorder

This study tests whether using urine sodium levels to guide diuretic dosing improves outcomes for emergency department patients with acute heart failure. About 474 adults with fluid overload will be randomly assigned to either the urine-guided protocol or standard care. The goal …

Researchers are collecting real-world data on the GORE VIABAHN VBX balloon expandable endoprosthesis when doctors use it as a bridging stent with branched and fenestrated endografts to treat aortic aneurysms that involve the renal and mesenteric arteries. The registry includes ad…

This study tests a new device that uses brain signals to time magnetic pulses for stroke rehabilitation. The device reads blood flow changes in the brain and fires a magnetic pulse at the right moment to boost brain activity. Researchers will first test the system in healthy adul…

This study tests a temporary heart pump called Impella ECP in 100 adults undergoing high-risk angioplasty. The pump helps maintain blood flow during the procedure. Researchers are checking if the device is safe and works as intended, with follow-up for 30 days after the procedure…

This study tests a needle-free connector with anti-reflux technology, a special stopper that prevents blood from flowing back into IV catheters. The goal is to see if it reduces complications like blockages, infections, and pain compared to standard connectors. The trial will inv…

This study tests whether adding an interleukin-6 receptor inhibitor (a drug that reduces inflammation) to standard emergency stroke treatment helps people recover better after a severe stroke caused by a large blood clot in the front part of the brain. About 692 adults who are el…

This study tests a new drug called VCT220 in 160 adults with high blood pressure who are also overweight or obese. Participants will take either VCT220 or a placebo pill for 20 weeks. The main goal is to see if VCT220 can safely lower blood pressure more than a placebo.

This early study is testing a device that uses ultrasound to ablate (calm) nerves in the pulmonary artery. The goal is to see if this procedure can improve quality of life for 50 people with heart failure and a specific type of pulmonary hypertension (Group 2). Participants will …

This early study tests a new catheter technique called VINTAGE for people with ventricular arrhythmia that hasn't improved with standard treatment. The procedure uses special catheters to reach and destroy heart tissue causing the abnormal rhythm. Thirty adults will be enrolled a…

This large phase 3 trial tests whether newer blood thinner combinations (ticagrelor plus aspirin or rivaroxaban plus aspirin) are better than the standard clopidogrel plus aspirin at preventing stroke, brain bleeding, or death from blood vessel disease. Over 1,600 participants wi…

This study looks at the long-term safety and effectiveness of a drug called lorundrostat for people with high blood pressure. About 1,076 adults who have already taken lorundrostat in a previous study will continue taking it for up to 36 weeks. The goal is to see if the drug keep…

This study tests whether a structured exercise program done at home can improve walking ability and overall recovery in people who recently had a stroke. About 208 adults who had a stroke within the past two weeks will be assigned to either the home exercise program or usual care…

This early-stage trial is testing a new treatment called KYV-101 for people with severe autoimmune diseases like lupus, scleroderma, and vasculitis. The treatment involves taking a patient's own immune cells, modifying them to target and destroy faulty B cells, and giving them ba…

This phase 3 study tests whether erenumab (Aimovig), a monthly injection already approved for adults, can prevent migraines in children aged 6 to 17 with episodic migraine. About 457 participants receive either the drug or a placebo for 3 months. The main goal is to see if the dr…

This early study looks at whether taking tirzepatide (Mounjaro) after sleeve gastrectomy surgery helps people lose more weight and improve conditions like diabetes and high blood pressure. About 42 adults with obesity will be split into two groups: one gets surgery alone, the oth…

This study tests an experimental drug called ALN-APP in 200 adults with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain. The drug is given via spinal injection and aims to slow disease progression and reduce new brain bleeds. Participants will be …

This study tests a special balloon coated with a drug to treat heart arteries that have narrowed again after a stent was placed. About 600 adults with this condition will be randomly assigned to receive either the drug-coated balloon or a standard balloon procedure. The goal is t…

This study tests a higher dose of the drug aflibercept (8 mg) given as an eye injection every 4 weeks to people with wet age-related macular degeneration (nAMD) or diabetic macular edema (DME). The goal is to see if this dosing schedule is safe and works well for those who have a…

This early study tests a new device (LAmbre II) that closes a small pouch in the heart called the left atrial appendage in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners. Ten participants will be followed for abo…

This registry collects data on lung transplant patients whose donor lungs were preserved and transported using the LUNGguard or BAROguard devices. Researchers track outcomes such as primary graft dysfunction, rejection, survival, ICU and hospital stays, readmissions, and time on …

Researchers at Penn State University are testing whether a healthy diet that includes two eggs every day changes cholesterol and other heart-health markers compared with a healthy diet that includes three eggs a week. The study enrolls about 65 adults with mildly elevated LDL cho…

This study tests a new treatment called cipaglucosidase alfa/miglustat in children (0 to under 18 years) with late-onset Pompe disease. The goal is to see if it is safe and how well it works. Participants either have never had enzyme therapy before or have been on it for at least…

This early-phase study tests a single injection of a gene therapy called V001-BCMA for people with autoimmune diseases like lupus that have not responded to standard treatments. The therapy targets and modifies specific immune cells to reduce disease activity. The main goal is to…

This study tests whether Empagliflozin (Jardiance), a drug used for diabetes and heart failure, can help adults born with heart defects who now have a weakened heart. Forty participants will receive either the drug or a placebo for one year. Researchers will measure changes in he…

Researchers compare two timings for giving the blood thinner heparin during minimally invasive heart procedures that require a puncture through the wall between the heart's upper chambers. Adults scheduled for mitral valve repair or left atrial appendage closure join the trial. O…

This study tests a special balloon coated with the drug paclitaxel to treat in-stent restenosis, where a previously placed stent in a heart artery narrows again. Twenty adults who have this condition will receive the balloon treatment or standard care. Researchers will check if t…

This study tests whether using a special camera (OCT) inside the heart's arteries during a heart attack procedure leads to better outcomes than the standard X-ray method. About 3000 people having a heart attack will be randomly assigned to one of the two approaches. The goal is t…

This study tests a new medicine called ALN-6400 for people with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and frequent nosebleeds. First, healthy volunteers will receive a single dose to check safety. Then, HHT patients will recei…

This study tests an experimental drug called BI 764524, given as an eye injection, in 190 adults with moderate to severe diabetic retinopathy. Participants receive different numbers of injections over a year, and doctors compare eye damage improvements against a sham procedure or…

This early study is testing a new device called the DurAVR™ THV System, which is a replacement heart valve placed through a small tube in the leg (TAVI procedure). The study includes 40 people with severe aortic stenosis or a failed surgical valve. The main goal is to see if the …

This study tested a new device called the ACURATE neo2, which replaces a narrowed heart valve without open-heart surgery. About 1,900 people with severe aortic stenosis received either the new device or a standard one. The goal was to see if the new device is safe and works as we…

This phase II trial tests whether intensive blood pressure management (targeting systolic BP below 120 mmHg) is better than standard care (below 140 mmHg) for patients with advanced kidney or thyroid cancer starting anti-angiogenic TKI therapy. The study enrolls 61 participants a…

This phase 4 study tests the drug mavacamten in 63 adults with a type of heart muscle disease called obstructive hypertrophic cardiomyopathy. The goal is to see if the drug can improve heart structure, measured by MRI, and ease symptoms like shortness of breath. Participants take…

Retinal vein occlusion happens when a clot blocks a vein in the eye, leading to vision loss. Current treatments manage the fluid buildup but do not remove the clot. This trial tests whether a robot can safely guide a tiny needle into the blocked vein to inject tPA, a clot-dissolv…

This international registry study looks at a small device called a transcatheter pulmonary flow restrictor, which doctors implant in the lung arteries of young children with congenital or acquired heart disease. The goal is to see whether the device safely and effectively control…

This study tracks people with severe eosinophilic asthma who already take Fasenra (benralizumab) every 8 weeks. Participants use electronic monitors on their regular inhalers and a study-provided rescue inhaler (AirSupra) to see if asthma control stays steady throughout the dosin…

This study tests a new device that replaces a leaky tricuspid heart valve using a thin tube inserted through a leg vein, avoiding open-heart surgery. It includes 150 people with severe tricuspid regurgitation who are too high-risk for surgery. The goal is to see if the device is …

This study tests a drug called mavacamten in 132 people with hypertrophic cardiomyopathy (thick heart muscle) that blocks blood flow in the middle or tip of the heart's main pumping chamber. The goal is to see if mavacamten can reduce the pressure difference across the blockage a…

This early-stage trial tests an experimental drug called BI 3000202 in 16 adults with rare type 1 interferonopathies, such as Aicardi-Goutières syndrome. Participants take a low dose for 4 weeks, then a higher dose for 36 weeks. The main goal is to see if the drug is safe and how…

This program allows individual patients with vascular disease or end-stage kidney disease on dialysis to request an experimental lab-grown blood vessel (ATEV) if they have no other treatment options and cannot join a clinical study. The vessel is designed to replace or bypass dam…

Researchers are testing two doses of an experimental eye implant called EC-104 against the standard Ozurdex implant in adults with diabetic macular edema. The trial enrolls people whose swelling did not improve enough with anti-VEGF injections but who have tolerated steroid eye t…

This early study tests whether QLS-111 eye drops can improve blood flow to the back of the eye in people with non-proliferative diabetic retinopathy or certain types of glaucoma. Fourteen participants will use the drops twice daily for two weeks. The main goal is to measure chang…

Researchers compare two common procedures for people with severely blocked coronary arteries and a heart that pumps poorly. One group receives coronary artery bypass graft surgery, and the other receives percutaneous coronary intervention, also known as stenting. The study tracks…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This study tests if a new, automated laser treatment (DSLT) works as well as the standard laser treatment (SLT) for lowering eye pressure in people with open-angle glaucoma. About 51 adults will receive one of the two treatments and be followed for 12 months. The goal is to see i…

People with liver cirrhosis can develop dangerous bleeding from swollen veins in the esophagus or stomach. Doctors use endoscopy to find and treat the bleeding, but they do not know the best time to do it. This trial randomly assigns patients to different endoscopy timings to see…

BP-REACH tests whether a team-based program can help people who have had a stroke or heart attack lower their blood pressure. Participants receive a home blood pressure monitor, self-management education, monthly coaching calls, and medication management from a pharmacist. Resear…

This study follows 300 people with blocked leg arteries who received a treatment using a balloon coated with paclitaxel and vitamin E. The goal is to see if the balloon keeps the artery open and prevents the need for repeat procedures over one year. Participants are adults with m…

This study tests a new device called the Navitor TAVI system to replace a stiff, narrowed heart valve without open-heart surgery. It includes 1,500 people with severe aortic stenosis who are at low or intermediate risk for surgery. The goal is to see if the device is safe and eff…

Researchers are testing whether a structured primary care program can help adults aged 40 to 90 with higher heart or diabetes risk reach recommended prevention targets. The program trains doctors and nurses, uses routine data to flag at-risk patients before visits, and provides d…

This study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…

This study tests two approaches—lifestyle medicine consultations and cognitive behavioral therapy (CBT)—to reduce cardiovascular risk in autistic individuals aged 9 to 26 who have a high body mass index. Participants are randomly assigned to receive lifestyle coaching, CBT sessio…

This study compares a device called FlowTriever (used with blood thinners) to blood thinners alone for people with intermediate-risk pulmonary embolism (blood clots in the lungs). About 1,200 adults with clots in major lung arteries and signs of heart strain will be randomly assi…

This large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …

This study tests a new system that combines a leadless pacemaker with a subcutaneous defibrillator to treat dangerously fast heart rhythms. The devices communicate wirelessly to deliver pacing therapy without wires inside the heart. About 300 people at risk for ventricular tachyc…

This study tests a new device called the VariPulse catheter, which uses short electrical pulses to treat atrial fibrillation (AF), a common heart rhythm problem. Twenty adults with AF will get this treatment, and after 2-3 months, doctors will check if the treated veins are still…

This study is testing a new device called the Cephea Mitral Valve System for people with mitral valve disease (leaky or narrowed heart valves) who cannot have open-heart surgery. The goal is to see if the device is safe and works well. About 20 people will take part.

This study compares two ways to fix a leaky mitral valve in people aged 60 and older: a less invasive procedure using a clip (TEER) versus traditional open-heart surgery. About 450 participants will be randomly assigned to one of the two treatments. The goal is to see if the clip…

This Phase 2 trial tests an inhaled medication called mosliciguat in 135 people who have both lung scarring (interstitial lung disease) and high blood pressure in the lungs. Participants are randomly assigned to receive either the drug or a placebo for 16 weeks. The study measure…

This early-phase trial is testing a new treatment called CC-97540, a type of CAR T cell therapy, in 12 people with severe ANCA-associated vasculitis that has not responded to standard treatments. The therapy is designed to target and destroy certain immune cells that drive the di…

Researchers are following people with high blood pressure who already received the Barostim Neo, a small implanted device that stimulates the body's own blood pressure sensors. The study tracks long-term safety and how well the device keeps blood pressure under control. Participa…

This study is testing a new stent device called the GORE® TAG® Thoracic Branch Endoprosthesis to treat aneurysms or lesions in the aortic arch and upper part of the main artery from the heart. About 250 participants will receive the device to see if it is safe and effective. The …

Researchers are testing a branched stent graft called the GORE TAG Thoracic Branch Endoprosthesis to treat aneurysms and other damage in the aortic arch and descending thoracic aorta. The device is threaded through blood vessels to the damaged area, where it seals off the weak sp…

This study tests whether a temporary heart pump can help high-risk patients during coronary stenting. The pump supports the heart's main chamber during the procedure, aiming to prevent heart failure or death. About 300 patients with severe coronary disease and weak heart muscle w…

This study looks at people with severe aortic stenosis (a narrowed heart valve) who don't yet have symptoms. Doctors usually wait until symptoms appear before replacing the valve, but by then the heart may already be damaged. The researchers use MRI scans to find hidden scarring …

This study follows 17 people with Pompe disease who have already taken part in earlier trials of avalglucosidase alfa (Nexviadyme). It aims to check the drug's long-term safety and effectiveness by giving it every two weeks as an IV infusion. The study will continue until the dru…

This study looks at whether semaglutide, a medicine for type 2 diabetes, can slow or prevent diabetic eye disease over 5 years. About 1500 adults with type 2 diabetes will receive either semaglutide or a placebo injection once a week, in addition to their usual diabetes medicatio…

This study offers continued access to an oral medication called levosimendan for people with pulmonary hypertension (high blood pressure in the lungs) and a type of heart failure where the heart pumps normally but is stiff. About 800 participants who completed a previous levosime…

This study looks at whether a special blood test (TEG-PM) can guide doctors in adjusting blood-thinning medications for people who have had leg artery surgery for peripheral artery disease. About 130 adults will have their blood tested before and up to 9 months after surgery, and…

This study tests whether a community program centered in churches can help people on Chicago's South Side better control their blood pressure. Researchers will work with local health workers and church leaders to adapt proven strategies from a large health system. The goal is to …

This study tests whether a newer type of dialysis filter (medium cut-off membrane) can reduce inflammation and improve heart function better than the standard filter in people with end-stage kidney disease. Thirty adults on maintenance hemodialysis will use each filter for three …

This study tests a new monthly injection called ziltivekimab in 10,000 people who recently had a heart attack. The goal is to see if it can lower the risk of having another heart attack, a stroke, or dying from heart disease. Participants will receive either the study drug or a p…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older who are already on a keto diet or starting the modified Atki…

This study tests a new device that uses shock waves to break up calcium deposits in heart arteries before placing a stent. About 335 adults with coronary artery disease will receive this treatment at up to 55 US sites. The goal is to see if the device helps stents work better and…

This phase II trial tests whether adding the immunotherapy drug nivolumab to the chemotherapy paclitaxel helps shrink tumors in people with angiosarcoma who haven't had taxane drugs before. For those who have already received taxanes, the trial tests a combination of nivolumab an…

This study tests a device called a motor neuroprosthesis, an implantable brain computer interface designed to help people with severe paralysis control digital devices like computers or tablets. The device aims to bypass damaged motor pathways and transmit brain signals directly …

This study is testing a device called the Indigo Aspiration System that suctions out blood clots in people with deep vein thrombosis (DVT) in the leg. The goal is to see if it safely and effectively removes the clot and restores blood flow. About 229 participants with recent DVT …

This trial is testing a device called the Aventus Thrombectomy System, which suctions out blood clots from the lungs in people with acute pulmonary embolism. The study involves 130 participants aged 18 to 80. The goal is to see if the device is safe and effective at improving blo…

This study tests whether adding spironolactone to standard blood pressure treatment helps lower blood pressure more effectively in people who have had a stroke. About 160 adults who had a bleeding or clot-caused stroke are taking spironolactone or continuing their usual care. Res…

This program provides access to an investigational drug called donidalorsen for people with hereditary angioedema (HAE), a genetic condition that causes sudden, painful swelling in various body parts. The drug is given as a monthly or every-other-month injection under the skin. I…

This pilot trial tests whether training with a portable robotic ankle exoskeleton, called AMBLE, can improve ankle push-off and walking speed in adults with chronic stroke and ankle weakness. Participants will complete 30 walking training sessions over 8 to 9 weeks while wearing …

This Phase 2 trial tests a one-time infusion of rapcabtagene autoleucel, a CAR-T cell therapy made from a patient's own immune cells, against standard treatments for severe active granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA). About 126 adults aged 18-7…

This study tests whether Dysport injections can prevent chronic migraines in adults. Chronic migraine means having at least 15 headache days per month, with 8 being migraines. Participants receive injections into head, neck, and shoulder muscles every 12 weeks for up to 60 weeks.…

This study tests an experimental drug called QCZ484, given as an injection under the skin every 6 months, for people with mild to moderate high blood pressure. About 385 adults aged 18 to 75 are taking part. The goal is to see if the drug safely lowers blood pressure compared to …

This study will test whether an artificial intelligence (AI) system can help community doctors better manage patients who have high blood pressure along with diabetes or high cholesterol. About 6,800 adults will be split into two groups: one where doctors use the AI tool to guide…

This trial tests whether an AI system that flags at-risk Medicare Advantage members and suggests care actions, reviewed by a nurse, can reduce overall healthcare spending over a year. About 9,900 participants in Utah are assigned to either this AI-supported navigation or usual ca…

This real-world study is following 7,000 Chinese adults with established heart disease to see if adding Repatha® (a cholesterol-lowering injection) to their usual care reduces major cardiovascular events like heart attacks, strokes, and heart-related death. Participants are eithe…

This study tests a new medicine, EYP-1901, given as an eye injection to people with diabetic macular edema (DME), a condition that causes blurry vision in people with diabetes. The goal is to see if EYP-1901 works as well as the standard treatment (aflibercept) but with fewer inj…

This early-stage study tests a new drug called ADX-850 in 28 people with mild to moderate high blood pressure. The drug uses siRNA technology to target genes involved in blood pressure regulation. The main goal is to check safety and how the drug moves through the body, with a se…

This phase 3 trial tests EYP-1901, a new eye injection, against the standard treatment aflibercept for diabetic macular edema (DME), a condition that causes vision loss in people with diabetes. The study will enroll 240 participants and compare how well each drug improves vision …

This study tests whether adding ablation of scarred heart tissue to standard pulmonary vein isolation helps people with persistent atrial fibrillation stay free of irregular heartbeats. Two hundred participants will be randomly assigned to one of two ablation procedures. The main…

This trial tests whether taking a daily low dose of colchicine, an anti-inflammatory drug, can reduce the risk of heart attacks, strokes, and other heart problems in Chinese patients who have had a stent placed for coronary heart disease. Researchers will compare two different do…

This first-in-human trial tests a small device called the FIRE1 System, which is implanted in a major vein to monitor fluid buildup in people with heart failure. The study enrolls up to 50 adults who have recently needed hospital care for heart failure. Researchers check whether …

Researchers at Duke University are testing whether giving supplemental oxygen during hemodialysis can improve pulmonary hypertension in adults whose oxygen levels drop during treatment. Participants receive either oxygen through a concentrator or room air during their regular dia…

This trial tests two early interventions for people who have had an ischemic stroke: a computerized cognitive training program for the patient and a psychoeducational program for the main caregiver. Both start about 20 days after hospital admission, much earlier than most rehabil…

This study tests whether the drug nicorandil can lower the risk of serious heart problems like heart attacks and strokes in people with coronary artery disease who are on kidney dialysis. Researchers are giving 15 mg of nicorandil daily to 268 participants and tracking heart-rela…

This study tests a special stent device (GORE EXCLUDER) to treat thoracoabdominal and pararenal aortic aneurysms—bulges in the main artery that can rupture. About 102 people will receive the stent through a minimally invasive procedure. Researchers will check if the device is pla…

Researchers are testing whether a defined plant-based diet can improve blood vessel function in people with coronary artery disease. Participants will follow the diet while researchers measure changes in blood vessel health and heart rhythm over time. The goal is to see if this d…

This study tests whether a personalized 12-week cardiac rehabilitation program, offered in a safety net clinic, helps more heart patients attend rehab compared to the usual referral to an outside program. Researchers will enroll 100 adults who have had a heart attack, surgery, or…

This early-stage study tests a gene therapy called AT845 for adults with late-onset Pompe disease, a condition that weakens muscles. The treatment aims to deliver a working copy of the GAA gene to muscle cells. Eleven participants who have been on standard enzyme replacement ther…

This early study tests a new device called the NORM™ system in 25 adults with heart failure. The device is placed inside a large vein near the heart to send health information to doctors. The goal is to see if the implant is safe and can reliably transmit data, which may help man…

This study tests doing two heart procedures at the same time for people with atrial fibrillation. First, doctors use pulsed field energy to fix the heart's rhythm. Then, they implant a small device to close off a part of the heart where clots can form. The goal is to see if this …

This study compares two ways of delivering cardiac rehabilitation: in-person sessions and telehealth sessions. Cardiac rehab includes exercise training, health education, and counseling for people with heart conditions like heart attack, heart failure, or after heart surgery. The…

This early-stage study tests a new drug, RO7497372, given as an eye injection for people with diabetic macular edema (DME), a condition that causes vision loss. The trial involves 151 participants and aims to check the drug's safety, how long it stays in the eye and blood, and it…

This study tests a new device that uses heat to destroy tiny areas in the heart causing short bursts of irregular heartbeat (paroxysmal atrial fibrillation). About 300 adults with this condition will receive the procedure and be monitored for a year. The goal is to see if the tre…

This phase 2 trial is testing the drug ruxolitinib in people with hypereosinophilic syndrome, a rare condition where the body produces too many eosinophils (a type of white blood cell), causing organ damage. The study aims to see if ruxolitinib can normalize blood cell counts and…

This study investigates whether omega-3 fatty acids, natural fats found in fish and flaxseed, can help manage blood sugar and reduce inflammation in people with type 2 diabetes and heart disease. Participants take omega-3 supplements or a placebo for 28 days, and researchers meas…

This trial tests whether L-carnitine, a natural compound, can reduce the damage that occurs when blood flow is restored to the heart after a heart attack. Researchers will give L-carnitine to patients with ST-elevation myocardial infarction (STEMI) who undergo angioplasty, and me…

This study tests whether a program using community health workers and medication can lower blood pressure and prevent heart failure in 364 adults from Detroit and Cleveland. Participants with high blood pressure or risk factors will receive personalized support and medication. Th…

This study tests whether adding dapagliflozin to baxdrostat reduces protein in the urine (a sign of kidney damage) better than baxdrostat alone. About 218 adults with chronic kidney disease and high blood pressure will take either the combo or baxdrostat plus a placebo. The goal …

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, type 2 diabetes, or high blood pressure. Participants use a tablet, scale, and activity tracker at home, and some get extra support from a co…

This study tests a new device (Laminar) to close the left atrial appendage, a small pouch in the heart, in 1500 people with non-valvular atrial fibrillation. The goal is to see if it is safer and works better than existing devices to reduce the risk of stroke and blood clots. Par…

This study tests a clinic program called ActivityChoice that helps cancer survivors become more physically active to lower their risk of heart disease. About 114 adult cancer survivors will be offered a choice of group in-person, group virtual, or self-monitored digital exercise …

This phase II trial tests whether an experimental drug called LT3001, given as a single intravenous infusion, can safely improve outcomes for people with acute ischemic stroke who are undergoing endovascular thrombectomy, a procedure to remove the blood clot. The study enrolls ad…

This trial tests whether community pharmacies can run a produce prescription program for adults with type 2 diabetes or hypertension. Participants receive a monthly card loaded with funds to buy healthy foods like fruits, vegetables, beans, nuts, and seafood at their usual grocer…

This study is testing a new device that uses pulsed electric fields to treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. The procedure aims to isolate the pulmonary veins to restore normal rhythm. Researchers will enroll 440 people who have not …

This trial tests whether adding brain stimulation techniques to standard swallowing therapy helps people who have trouble swallowing after a stroke. Researchers will compare neuromuscular electrical stimulation (NMES) alone with NMES combined with either transcranial direct curre…

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This trial tests a device called the Akura Thrombectomy System, which is threaded through a catheter to mechanically remove blood clots from the lungs. The study enrolls adults with acute pulmonary embolism, a condition where clots block blood flow in the lungs and strain the hea…

This study is testing a device called the Akura Thrombectomy System, which is threaded through a blood vessel to mechanically remove clots from the lung arteries. It involves 118 adults with acute pulmonary embolism (symptoms for 14 days or less) who have a clot in a main or loba…

This study tests whether the drug sacubitril/valsartan can reduce scarring in the heart muscle of people with a type of heart failure called HFpEF (stiff heart). The trial will enroll 36 adults aged 50 and older with heart failure and a normal pumping function. Participants will …

This trial tests a device called the ATC System in people with acute pulmonary embolism, a condition where blood clots block arteries in the lungs. The device aims to mechanically remove the clots and restore blood flow. Researchers will measure how well it reduces heart strain a…

This trial tests a device called the TricValve system in people with severe tricuspid regurgitation, a condition where the heart's tricuspid valve leaks blood backward. The device is implanted through a catheter into the veins leading to the heart, aiming to reduce symptoms witho…

This trial compares two strategies for placing stents in people with coronary artery disease, where arteries that feed the heart become narrowed. One strategy uses a blood-flow measurement called fractional flow reserve to decide whether a stent is needed. The other uses intravas…

This trial tests whether sparsentan, a tablet that blocks a chemical called endothelin and lowers blood pressure, can improve blood vessel function and reduce stiffness in people with ANCA-associated vasculitis. Vasculitis is an autoimmune disease that damages blood vessels and r…

This study tests whether high-intensity interval training (HIIT) can improve cardiovascular health in adults who had surgery to repair coarctation of the aorta, a narrowing of the main artery. Participants are randomly assigned to do HIIT at home, HIIT in a supervised clinic, or …

This early-stage trial is testing whether focused sound wave pulses applied to the head—called transcranial pulse stimulation—can help people recover from a recent ischemic stroke. The study includes adults aged 20 to 80 who had a stroke 1 to 6 months ago and still have motor or …

This trial tests whether a supervised 12-week high-intensity interval training (HIIT) program can safely improve cardiorespiratory fitness in adults who have previously had spontaneous coronary artery dissection (SCAD), a cause of heart attack that often affects younger women. Pa…

This trial tests a new model where patients with infections receive intravenous antibiotics at home instead of staying in the hospital. Nurses from a municipal response team visit the patient, while hospital doctors oversee the treatment remotely using telemedicine and welfare te…

This trial tests whether a dietary supplement called Endocalyx Pro can reduce excess sodium and water in people with chronic heart failure. Participants will take either the supplement or a placebo daily for 8 weeks, with follow-up for 12 weeks. The study measures changes in a bl…

This trial tests whether a procedure to remove blood clots from veins in the brain works better than standard blood-thinning medication for people with cerebral venous sinus thrombosis (CVST), a rare type of stroke. Participants will be randomly assigned to receive either the end…

This trial tests whether high-dose vitamin D supplements can improve cognitive function in people who have had a stroke and developed thinking or memory problems. Participants will receive either vitamin D or a placebo for six months, and researchers will measure changes in cogni…

This early trial is testing a small, implantable sensor that measures pressure inside the heart for people with heart failure who are getting a mechanical heart pump (LVAD). The goal is to see if the sensor can be safely and accurately placed and whether it can provide reliable p…

This trial tests whether cryoablation, a procedure that freezes heart tissue to block faulty electrical signals, can control early persistent atrial fibrillation (AF) when used as the first treatment. Participants have symptomatic AF that has lasted between 7 days and 3 years and…

This study tests whether personalized education generated by artificial intelligence can help adults with hypertension learn more about their condition and take their medication more consistently, compared to a standard printed booklet. About 88 adults with high blood pressure wi…

This trial is testing a new device called the HARPOON system, which is designed to repair a leaky mitral valve in the heart while it is still beating, avoiding the need for open-heart surgery. The study will include people with severe degenerative mitral regurgitation, a conditio…

This study is testing a device called PASCAL, which is used to repair a leaky mitral valve in the heart without open-heart surgery. The procedure involves guiding a small clip through a blood vessel to the heart to help the valve close properly. Researchers are following about 1,…

This study compares two approaches for replacing an infected aortic valve: using a cryopreserved aortic homograft (a preserved human donor valve) versus conventional mechanical or tissue prosthetic valves. The goal is to see which method leads to fewer complications, such as deat…

This pilot trial is testing whether a device called the Coronary Sinus Reducer can help people with angina (chest pain) who have no significant blockages in their coronary arteries. The device, shaped like an hourglass, is placed into a vein in the heart to improve blood flow. Th…

This trial investigates the best way to treat people who have a heart attack and also have other narrowed arteries. It compares doing an immediate procedure to open those other arteries, guided by a pressure wire, versus waiting and using a heart scan to decide later. The goal is…

This trial tests an automated system called ADIVA that delivers two medications to control blood pressure during spinal anesthesia for cesarean delivery. Low blood pressure is a common side effect of spinal anesthesia and can cause problems for both mother and baby. The system ai…

This Phase I trial tests whether infusing specially trained immune cells, called TAA-T, can safely target and attack high-risk brain tumors in children and adults. The cells are made from the patient's own blood and are designed to recognize multiple tumor-related proteins, poten…

This trial asks whether giving only ticagrelor (a blood thinner) after a heart attack, instead of the usual ticagrelor plus aspirin, is just as safe and might reduce bleeding and heart muscle damage. About 200 people who had a type of heart attack called STEMI and underwent a ste…

This trial tests whether taking a 15-minute hot bath after each exercise session improves recovery in people who recently had a heart attack. Half of the 30 participants will do standard exercise rehab plus hot water immersion, while the other half does exercise alone. The study …

This trial is testing whether a supervised exercise program can reduce the risk of death, another heart attack, or stroke in people who have already had a heart attack. About 9,700 participants will be randomly assigned to either a four-year program with a personal trainer or to …

This study tests a new approach called 'pill-in-pocket' anticoagulation for people with atrial fibrillation (AF), a heart rhythm condition that raises stroke risk. Instead of taking blood thinners every day, participants would stop them after a 30-day AF-free period and only rest…

This trial is testing a temporary stent system designed to open blocked arteries below the knee in people with peripheral arterial disease. The stent is used along with a drug-coated balloon to help keep the vessel open. The study will check how well the treated arteries stay ope…

This trial compares standard versus extra pulsed field ablation applications during pulmonary vein isolation in people with atrial fibrillation. The goal is to see if more targeted ablations improve freedom from irregular heart rhythms for up to 18 months. Participants are adults…

This trial tests whether a digital tool that prompts doctors to adjust heart failure medications can improve care. The tool uses home monitoring and patient data to suggest medication changes. The study includes over 1,300 adults with heart failure and will measure hospitalizatio…

This trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…

This trial is testing a new type of heart valve made from a material that the body absorbs over time. It is designed for children and young adults who need surgery to fix a congenital heart defect affecting the passage from the heart to the lungs. The valve is implanted during su…

This study asks whether wearing a small heart monitor for two weeks at a time, twice, can better detect hidden irregular heartbeats (atrial fibrillation) in older adults who recently had a stroke or mini-stroke, compared to the usual 1-2 day monitoring. Atrial fibrillation is a m…

This trial tests whether a personalized exercise prescription, based on a graded exercise test and target heart rate, improves fitness more than standard perceived exertion-based exercise in older adults (60+) recovering from heart events like heart attacks or heart surgery. Part…

This trial tests whether a procedure called renal denervation can safely lower blood pressure in people with chronic kidney disease (stage 3) whose hypertension is not controlled by medication. The procedure uses ultrasound energy to calm overactive nerves in the kidney that may …

This study looks at how well the iCover stent works when used as a bridging stent during a procedure called fenestrated endovascular aneurysm repair (fEVAR) for complex abdominal aortic aneurysms. The goal is to see if the stent stays open and keeps the aneurysm sealed without co…

This study tests a new type of balance training for people who had a stroke within the past few weeks. The training uses controlled wobbles and shifts in the support surface to challenge patients' balance in a safe way, aiming to improve their ability to walk and perform daily ac…

This trial is testing whether a catheter that suctions out blood clots can restore blood flow to the intestine in people with acute mesenteric ischemia, a life-threatening blockage of the artery feeding the gut. Participants will undergo thrombus aspiration, and if needed, laparo…

This study tests whether a focused, intensive stepping training program, called FIRST, can improve walking ability in people recovering from a recent stroke. Participants in inpatient rehabilitation receive physical therapy that prioritizes walking practice at higher cardiovascul…

This trial tests whether using optical coherence tomography (OCT) during a procedure to reopen a chronically blocked carotid artery is safe. The blockage can cause strokes, and doctors often need to see what's inside the artery after crossing the blockage. OCT provides high-resol…

This trial tests two methods of harvesting the left internal mammary artery for heart bypass surgery. One method strips the artery clean of surrounding tissue; the other leaves the tissue intact. Researchers want to know which approach keeps the graft open longer and reduces the …

This trial tests whether an 8-week course of the immunosuppressive drug prednisone can reduce episodes of ventricular tachycardia (a potentially fatal fast heart rhythm) and improve heart function in people with non-ischemic cardiomyopathy and confirmed heart inflammation. Partic…

This trial compares two types of transcatheter heart valves—one designed to sit above the natural valve opening (supra-annular) and one that sits within it (annular)—in people with severe aortic stenosis and a small aortic annulus (≤23 mm). The goal is to see which valve leads to…

This study tracks the safety of avacopan, a medication for ANCA-associated vasculitis, an autoimmune disease that causes blood vessel inflammation. Researchers will compare side effects like liver injury, heart problems, serious infections, and cancer in people taking avacopan ve…

This study tests whether a home-visit program called PAT+HEALTH can help pregnant women with obesity in Nigeria improve their heart health and manage weight. About 1,000 women will be randomly assigned to receive the program or standard care. Researchers will track weight, lifest…

This trial investigates whether a shorter course of antibiotics, tailored to each patient's response, can treat left-sided endocarditis as safely as the standard 4-6 week regimen. Adults with endocarditis caused by specific bacteria (Streptococci, Enterococcus faecalis, or Staphy…

This trial investigates whether a shorter course of antibiotics, tailored to each patient's response, can safely treat bacterial endocarditis. Standard treatment lasts 4-6 weeks, but this study tests a personalized approach based on factors like fever and blood tests. The goal is…

This trial tests whether a personalized training program called 'Kleuter Extra' can improve executive functioning—skills like attention, self-control, and planning—in preschoolers aged 4 to 6 who have severe congenital heart disease. Many children with this condition face thinkin…

This study tests a prototype smartphone app called Appet HEART, designed to support personalized care for people with coronary artery disease after they leave the hospital. Researchers want to see how often patients use the app, who benefits most, and whether it improves recovery…

This study follows 100 adults with primary open-angle glaucoma who had a goniotomy procedure using the C-Rex surgical instrument. The goal is to see how well the surgery lowers intraocular pressure and reduces the need for glaucoma medications over 12 months. Researchers will als…

This study tests whether adding a PCSK9 inhibitor (a powerful cholesterol-lowering drug) to high-intensity statin therapy can prevent future cardiovascular events in people who have recently had a heart attack or unstable angina and underwent a stent procedure. About 1,200 partic…

This study investigates whether intensively lowering systolic blood pressure with FDA-approved medications can reduce the buildup of amyloid and tau proteins in the brain—hallmarks of Alzheimer's disease. The trial enrolls adults aged 60-85 with high blood pressure who are cognit…

This trial tests a procedure called pulmonary arterial denervation (PADN) for people with heart failure who also have high blood pressure in the lungs. A special catheter delivers radiofrequency energy to nerves in the pulmonary artery, which may help lower pressure and improve h…

This study tests an experimental drug, NPI-001 (AT-001), in people with hereditary cystatin C amyloid angiopathy (HCCAA), a rare genetic condition that causes repeated brain bleeding and stroke. The trial includes about 15 participants aged 12 and older who carry the specific L68…

This study tests a wrist-worn device called CardiaCare RR2 that stimulates the median nerve to calm irregular heart rhythms after catheter ablation for atrial fibrillation (AF). About 34 adults who have had AF ablation will use the device daily for six months. Half will receive a…

This trial tests whether a dietary supplement called Tertinat, containing epigallocatechin-3-gallate, can reduce major heart problems in people with atherosclerosis who have recently had bypass or stent surgery. Over two years, participants take either the supplement or a placebo…

This study investigates whether diagnosing and treating obstructive sleep apnea with CPAP therapy early, while patients are still in the hospital for heart problems, can reduce the chance of being readmitted within 30 days. The trial enrolls adults with heart failure, heart attac…

This trial tests whether placing a balloon in the aorta (REBOA) during CPR can improve blood flow to the heart and brain in people who have a cardiac arrest outside the hospital. The study includes 200 adults with non-traumatic cardiac arrest who receive CPR within 10 minutes. Re…

This trial tests a new device called the Edwards SAPIEN M3 System for people with severe mitral regurgitation, a condition where a heart valve leaks blood backward. The device is placed using a thin tube threaded through blood vessels, avoiding open-heart surgery. The study inclu…

This trial tests whether adding posterior wall isolation to standard pulmonary vein isolation reduces atrial fibrillation recurrence in people with persistent AF. About 482 adults aged 20 to 80 will be randomly assigned to one of the two procedures using pulsed-field energy. Part…

This study evaluates a special balloon coated with sirolimus, a drug that helps prevent arteries from narrowing again after angioplasty. The balloon is used during routine procedures to open blocked heart arteries in people with coronary artery disease. Researchers are tracking h…

This trial tests a device called the Edwards PASCAL system, which is used to repair a leaky tricuspid valve in the heart without open-heart surgery. The study includes 300 people with severe tricuspid regurgitation who are candidates for this procedure. Researchers are checking h…

This study investigates whether adding two common drugs—valsartan (for high blood pressure) and celecoxib (for arthritis pain)—to standard metformin therapy can improve blood sugar control in people with type 2 diabetes. The trial enrolls adults with obesity, high blood pressure,…

This study investigates whether long-acting parathyroid hormone (PTH) analogues can reduce signs of early heart and blood vessel damage in adults with chronic hypoparathyroidism. Researchers will compare artery stiffness and heart function in people taking the PTH analogue palope…

This study tests whether a structured 5-part nursing care bundle can reduce dangerous blood clots (venous thromboembolism) after total hip replacement surgery. The bundle includes patient education, ankle exercises, early walking, fluid management, and compression stockings. Abou…

This trial tests whether using a special camera inside the arteries (optical coherence tomography, or OCT) is better than standard pressure-wire measurements for deciding which non-blocked arteries need stenting in people who have just had a heart attack. About 1,425 participants…

This study tests a new treatment called NXC-201 CAR-T for people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. The therapy uses a patient's own immune cells, modified to target and destroy the cells producing these proteins. The trial is open to …

This trial tests whether a quick procedure called umbilical cord milking—pushing blood from the cord into the baby before clamping—can improve brain development in newborns who are limp or not breathing well at birth. The study follows over 3,400 infants from the earlier CORDMILK…

This study follows about 3000 people with complex coronary artery disease who receive the Ultimaster Nagomi stent, a device that slowly releases a drug to keep arteries open. The goal is to see how often the stent fails—meaning heart-related death, heart attack, or need for anoth…

This study tests whether a fully online exercise program is practical and acceptable for people with heart failure. Participants are randomly assigned to either a supervised online exercise group or a self-managed home exercise program for 8 weeks. The goal is to see if people st…

This study tests whether a gentle, targeted electrical stimulation to the brain (HD-tDCS) can safely improve how stroke survivors perceive vertical balance. Participants who have had a stroke affecting one side of the brain will receive either active or sham stimulation while per…

This trial investigates whether intravenous infusions of tiny particles (extracellular vesicles) from heart progenitor cells can safely improve heart function in people with severe dilated cardiomyopathy and heart failure. Participants receive three infusions and are monitored fo…

This trial tests a long-acting injection of leuprolide acetate in children with central precocious puberty, a condition where puberty starts too early. The goal is to suppress puberty-related hormones, slowing or stopping early development. The study includes children aged 4 to 9…

This study tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS), combined with paired associative stimulation (PAS), can improve arm and hand movement in people who have had a stroke. The trial includes 40 adults who experi…

This study tests a transitional care model for older adults (65+) hospitalized with heart failure, COPD, or pneumonia. The model provides extra education, social services, and coordination among doctors after discharge. Researchers compare this to usual care to see if it reduces …

This study compares two versions of a three-drug combination eye drop for glaucoma: one with preservatives and one without. Researchers want to see if the preservative-free version is gentler on the eye surface and leads to better treatment adherence. Participants will also use a…

This trial investigates whether using a device to continuously measure pressure inside the brain's fluid-filled spaces can improve outcomes for people who have had a bleeding stroke from a ruptured aneurysm. About 372 adults with moderate to severe bleeding will be randomly assig…

This study tests whether strengthening the muscles used for breathing can improve exercise capacity, heart function, and quality of life in people with chronic heart failure. Participants with reduced or mildly reduced heart pumping ability will be randomly assigned to one of two…

This study looks at whether starting daily low-dose aspirin in the first trimester (weeks 1–12) is safer and more effective than starting in the second trimester (weeks 13–27) for pregnant women with sickle cell disease. Researchers will track maternal deaths, preterm births, and…

This study tests whether a mechanical heart pump called the HeartMate III (an LVAD) helps people with end-stage heart failure live longer and with fewer strokes compared to taking standard heart failure medications. About 80 adults with severe heart failure are randomly assigned …

This study looks at how prostate cancer treatments, especially hormone therapy, affect heart health. It includes two parts: one that follows men over time to track heart problems, and another that tests whether a program of healthy eating, exercise, smoking cessation, and medicat…

This study investigates whether empagliflozin, a drug typically used for diabetes, can help people with worsening heart failure get rid of extra fluid. Researchers will give 60 participants either empagliflozin or a placebo for six weeks, alongside their usual diuretic medication…

This trial tests whether a chelation therapy infusion—a cocktail that removes toxic metals from the blood—can reduce the risk of heart attacks, strokes, and leg amputations in people with diabetes and critical limb ischemia (severe blockage in leg arteries). Half of the 50 partic…

This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo inj…

This study tests a new drug called TS23, a monoclonal antibody designed to help break down blood clots in the lungs. It is for people with intermediate-risk pulmonary embolism, a serious condition where clots block blood flow. The trial compares different doses of TS23 against a …

This study looks at whether giving people a heart-lung machine (ECPR) right where they collapse from a cardiac arrest can help more of them survive to leave the hospital. Researchers will compare people who get this extra treatment with those who get standard CPR and care. The st…

This study tests whether a reduced dose of the clot-dissolving drug alteplase, given alongside standard blood thinners, can improve outcomes for people with intermediate-high-risk pulmonary embolism (a serious blood clot in the lungs). About 800 adults with confirmed acute pulmon…

This trial tests whether a home-based tele-rehabilitation program is as effective as traditional center-based cardiac rehabilitation for people who have recently had a heart attack (acute coronary syndrome). Participants will either complete 20 sessions at a rehab center or 20 se…

This study tests whether a supplement called sulforaphane, found in broccoli sprouts, can help prevent age-related declines in heart function. Researchers will give the supplement or a placebo to adults over 60 with a type of heart failure called HFpEF. They will measure heart fu…

This study tests whether showing people images of their own carotid arteries (the main arteries in the neck) can improve how they and their doctors manage heart disease risk. Participants are adults aged 40, 50, or 60 who are already part of a health program in Sweden. Some recei…

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This study tests whether switching to avalglucosidase alfa is safe and more effective for people with late-onset Pompe disease whose condition has worsened on the standard treatment, alglucosidase alfa. Participants receive biweekly infusions of the new drug and are monitored for…

Researchers are studying whether artificial intelligence can extract useful warning signs from coronary CT angiography (CCTA) scans in people with coronary artery disease. The study reviews existing medical records from 3,000 patients across five hospitals who had both a CCTA and…

Researchers compare two types of CT scanners for imaging heart arteries in people with suspected chronic coronary syndrome. One scanner uses standard energy-integrating detectors, while the other uses newer photon-counting detectors that may produce clearer pictures with fewer fa…

Researchers test whether an AI algorithm called AK-AVS can spot moderate-to-severe aortic stenosis, a narrowing of the heart's aortic valve, in older adults who have not been diagnosed. The study reviews about 4,000 routine electrocardiograms (ECGs) already collected during prima…

During cardiac arrest, rescuers check for a pulse by hand, but studies show this method is often wrong. This trial tests whether a carotid ultrasound in pulsed-wave Doppler mode can detect a pulse more accurately and quickly. Researchers will compare ultrasound findings with manu…

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder that can cause dangerous blood clots. Researchers want to know how often PNH appears in people under 50 who have had a stroke, mini-stroke, or brain vein clot with no clear cause. The study will screen 200 partici…

Researchers are testing whether an implanted loop recorder can detect atrial fibrillation in people who have had a stroke. The device continuously monitors heart rhythm for up to a year or longer. The pilot trial enrolls 24 patients across three centers to see if a larger study o…

This study compares two blood test schedules for diagnosing heart attacks in the emergency room: the standard 3-hour test and a newer 1-hour test. Over 64,000 adults with chest pain will be enrolled to see if the faster test is just as safe and accurate. If it works, patients cou…

Researchers are testing whether an artificial intelligence system can analyze echocardiogram images and draft reports as accurately as experienced sonographers in patients with heart failure. The trial enrolls adults with new or worsening heart failure symptoms and elevated heart…

Researchers are testing a noninvasive ultrasound method called ARFI to see if it can detect features of carotid plaque that raise stroke risk. The study includes adults with narrowed carotid arteries, some with symptoms and some without. By measuring plaque characteristics, the t…

Researchers are studying whether high levels of a blood protein called Galectin-3 can predict which patients will develop an irregular heartbeat after coronary artery bypass grafting. About 90 adults scheduled for this surgery will give a blood sample before the operation and be …

After a traumatic brain injury, pressure can build inside the skull and cause serious harm. Doctors usually rely on a CT scan to spot this, but moving a critically ill patient to the scanner carries risks. This study tests two non-invasive ultrasound methods, transcranial Doppler…

Researchers at Beijing Anzhen Hospital are studying whether a computer model that combines two types of heart scans can predict 12-month survival in people with light-chain cardiac amyloidosis, a condition where abnormal proteins stiffen the heart. The study enrolls 49 patients w…

This trial evaluates a new device called the Photobionic IOP Tonometer (PIB) that measures eye pressure without touching the eye or using an air puff. It uses a low-power infrared light and a gentle sound to detect tiny movements on the eye's surface, which a computer analyzes to…

Researchers are testing whether artificial intelligence can combine ultrasound images with routine health data to track changes in a person's physiology over time. The study enrolls adults with heart, lung, kidney, or blood vessel conditions, as well as healthy volunteers. The go…

This study looks at two new methods to tell apart blockages in large versus tiny heart arteries. About 68 adults with known or suspected coronary artery disease will get a PET scan and a heart catheterization. Researchers will compare the new measurements with standard tests to s…

This trial tests whether actively screening adults with obesity for early signs of heart failure can improve their health outcomes. Adults aged 45 and older with a BMI of 30 or higher, who have no known heart disease, will be randomly assigned to receive either standard care or a…

This study asks whether tiny RNA molecules in the blood can signal a higher risk of dangerous heart rhythms in people who have heart failure after a heart attack and use an implanted defibrillator. Researchers collect blood samples from 57 participants and compare RNA patterns be…

This trial tests whether a point-of-care blood test for NT-proBNP, which gives results at the bedside in about 12 minutes, can help doctors diagnose new heart failure faster in hospital patients with unexplained breathlessness. Researchers will compare time to diagnosis, time to …

This trial tests whether a smartwatch can accurately detect atrial fibrillation (AF) in people at high risk, such as those who've had a stroke or have symptoms. Participants will wear the CS Medical Watch while also having an implantable loop recorder (ILR) in place, and the watc…

This trial tests whether a portable home sleep apnea test can be as effective as an in-laboratory sleep study for diagnosing obstructive sleep apnea in people with high blood pressure. Participants are randomly assigned to either the home test or the lab test, and researchers com…

This trial is testing whether a new PET imaging tracer, 18F-flurpiridaz, can detect coronary artery disease as accurately as the current standard, 82Rb-chloride. The study will involve 60 adults scheduled for a clinically indicated PET scan. Researchers will compare the diagnosti…

This trial tests whether a coronary CT angiography (CCTA) scan can safely identify heart attack patients who do not need invasive angiography. About 300 patients with non-ST-elevation myocardial infarction (NSTEMI) will undergo CCTA before the standard invasive test. The goal is …

This trial is developing an artificial intelligence system that reads electrocardiograms (ECGs) to detect congenital heart disease in children. Researchers are collecting ECG data from thousands of children, including those with common and rare heart defects, to train a deep-lear…

This study is testing whether artificial intelligence can detect transthyretin amyloid cardiomyopathy (ATTR-CM), a serious and often underdiagnosed heart condition, earlier than usual. Researchers will use AI algorithms to analyze routine ECGs and heart ultrasounds from up to 1.5…

This study tests whether a compact 3-lead ECG device can accurately detect acute coronary syndrome (heart attack) in adults arriving at the emergency department with chest pain. Participants receive a HeartBeam ECG recording within 10 minutes of the standard 12-lead ECG. The goal…

This trial tests whether adding a polygenic risk score (a DNA-based estimate of heart disease risk) to standard risk assessment helps better identify who needs preventive measures like statins or lifestyle changes. About 205 adults aged 40–69 with intermediate cardiovascular risk…

This study evaluates RDX-Aneurysm, a computer-assisted detection software designed to help radiologists find saccular intracranial aneurysms (bulging blood vessels in the brain) on MRI scans. Researchers will analyze 550 past scans—half with confirmed aneurysms and half without—t…

This study explores whether a community-based cooking program can help African-American adults at risk for heart disease cook and eat healthier. About 43 participants from Washington, D.C. will take surveys, attend cooking classes led by a chef, and track their eating habits. The…

Researchers are testing whether combining pulsed-field ablation with left atrial appendage occlusion in a single procedure can control atrial fibrillation and prevent stroke. The trial enrolls 200 adults with non-valvular atrial fibrillation and a higher stroke risk. Participants…

This study tests whether the diabetes drug metformin, combined with lifestyle changes like diet and exercise, can reduce episodes of atrial fibrillation (an irregular heartbeat) in people with pacemakers or defibrillators. About 175 participants will take metformin or a placebo a…

Researchers at Cornell University are testing whether a produce prescription program helps adults who have diet-related conditions and trouble affording food. Participants receive weekly boxes of fresh local produce for 8 to 24 weeks and attend eight nutrition education classes. …

Antiphospholipid syndrome (APS) raises the risk of blood clots and strokes, and doctors often prescribe warfarin to prevent another stroke. Warfarin requires frequent blood tests and carries bleeding risks, especially for younger patients. This trial compares clopidogrel-based an…

Researchers test whether cutting certain nerves around the heart during open-heart surgery can prevent atrial fibrillation, a common irregular heartbeat after the operation. The trial enrolls 560 adults scheduled for elective open-heart surgery. Half receive standard surgery plus…

Researchers test whether flecainide, an antiarrhythmic drug, can prevent atrial arrhythmias in adults who have a patent foramen ovale (PFO) closed after a cryptogenic stroke. Participants receive flecainide or standard care for 3 to 6 months. An insertable cardiac monitor records…

Blood clots after major cancer surgery are common and dangerous, but patients often leave the hospital without medicine that lowers that risk. Researchers at the Medical University of South Carolina are testing whether educating surgeons and adding an electronic alert in the medi…

This study tests a new medication called IPN10200, given as injections into the head and neck muscles, to prevent migraines in adults. About 641 people with episodic or chronic migraine will receive either the drug or a placebo. The goal is to see if it safely reduces the number …

This phase 3 study tests whether Dysport (a botulinum toxin type A) injections can prevent episodic migraine in adults. About 751 participants receive either Dysport or placebo injections every 12 weeks for up to 36 weeks. The goal is to see if the treatment reduces the number of…

This study tests a new medicine called atogepant to prevent migraines that happen around a woman's period. About 430 adult women with regular cycles and a history of migraines will take either atogepant or a placebo daily for 3 menstrual cycles. The goal is to see if the drug red…

This large Phase 3 study tests whether inclisiran, a twice-yearly injection, can prevent major heart problems like heart attacks, strokes, and heart-related death in people at high risk who have not yet had such an event. Over 14,000 participants are receiving either inclisiran o…

This trial tests whether routinely screening heart attack patients for H. pylori, a common stomach bacteria, can prevent upper gastrointestinal bleeding. The bacteria can cause ulcers that bleed, especially when patients take blood thinners after a heart attack. Researchers will …

This study tests whether adding metal coils to the aneurysm sac during standard endovascular repair (EVAR) can prevent type II endoleaks—a common complication where blood flows backward into the aneurysm. About 100 high-risk patients will be randomly assigned to receive EVAR alon…

This trial tests whether intensive heart rhythm monitoring after a stroke can prevent another stroke. People who have had a stroke may have atrial fibrillation, a heart rhythm problem that comes and goes and is easy to miss. Researchers compare standard care with extra monitoring…

This trial tests whether a structured prevention bundle can reduce delirium in adults aged 70 and older admitted to a cardiac intensive care unit (CICU). Participants are randomly assigned to either usual care or the bundle, which includes daily pain checks, avoiding sedatives wh…

This trial is testing a device called the Vine™ Embolic Protection System, which is implanted in the carotid arteries to trap blood clots before they travel to the brain. It is designed for people with atrial fibrillation who are already taking blood thinners but still have a hig…

This trial tests whether a combination of lifestyle interventions—brain training, yoga, music therapy, and a special diet—can slow or reverse early signs of neurological disorders like dementia, stroke, epilepsy, and Parkinson's disease. Participants are healthy adults aged 50 an…

Researchers are testing whether human urinary kallidinogenase, a protein-based drug, can improve recovery in adults who have had an acute ischemic stroke and received standard reperfusion treatment such as clot-busting drugs or clot-removal procedures. The trial enrolls about 1,2…

Researchers are testing whether a rehabilitation robot combined with neuromuscular electrical stimulation can improve upper limb movement in people who had a stroke at least six months earlier. The study enrolls 48 adults with moderate arm impairment. Participants receive up to 2…

This study tests whether combining a brain-computer interface with virtual reality can improve arm and hand movement in stroke survivors. Twelve adults who had a stroke 6 to 24 months ago will each try both the VR-enhanced training and a standard brain-computer interface training…

This study tests a small device called Cerogrin that gently stimulates a nerve in the ear, aiming to improve thinking and memory in people with vascular dementia or mild cognitive impairment. Twenty-four participants will use the device at home for 30 minutes daily over four week…

Researchers are testing whether a suture-based closure device helps patients recover faster after heart procedures that use a large tube placed in the femoral vein. The trial enrolls adults undergoing procedures such as atrial fibrillation ablation, leadless pacemaker insertion, …

Researchers are testing whether isometric handgrip training, squeezing an inflatable ball in a steady hold, can lower resting blood pressure in people doing cardiac rehabilitation from home. Adults with coronary artery disease who are cleared for exercise-based rehab join the stu…

People on hemodialysis receive needle sticks through a fistula or graft several times a week, and the pain and anxiety can build over time. This trial tests whether slow, deep breathing combined with lemongrass aromatherapy reduces pain and anxiety during needle insertion. Resear…

This study is testing a digital care program for adults with migraine. The program includes a wearable device that uses nerve stimulation, personalized exercises, and support from a care team. The goal is to see if it can reduce the number of migraine days per month. About 140 pe…

Researchers are testing whether manual vagus nerve stimulation, a hands-on technique that targets the vagus nerve without surgery or electrical devices, can improve movement, autonomic function and thinking skills in people who had a stroke at least six months earlier. Participan…

This study looks at whether wearing compression stockings for a longer time after foam sclerotherapy (a treatment for varicose veins) can reduce skin darkening (hyperpigmentation) above the treated veins. About 140 adults with varicose veins will be followed for 28 days after the…

Researchers are testing whether Azerbaijani national dance sessions can improve cardiorespiratory fitness and quality of life in older adults with chronic heart failure. The trial enrolls 120 people aged 65 to 85 whose heart failure is confirmed by an ejection fraction between 40…

After coronary artery bypass grafting, doctors place tubes to drain fluid from around the heart. This trial compares two ways of monitoring that drainage: using gentle negative pressure (suction) or letting it drain on its own. Researchers will track fluid buildup around the hear…

This study tests whether a 12-week web-based support program can improve wellbeing in adults who survived a cardiac arrest 1 to 3 months earlier. The program includes educational modules, videos, breathing exercises, and a chat forum. Researchers will compare 120 participants who…

This study tests a new program called PA-ChatS that helps people increase physical activity in the first 6 weeks after a stroke. Participants wear a Fitbit to track steps and have weekly phone meetings with an occupational therapist for 6 weeks. The study includes 25 stroke survi…

Doctors close the groin vein puncture after atrial fibrillation ablation either with a suture-based device called Perclose ProGlide or with a traditional figure-of-8 stitch. This trial randomly assigns 90 adults to one of the two methods and asks them how satisfied they are with …

Researchers are testing whether adding glenzocimab to standard endovascular therapy improves recovery in adults with acute ischemic stroke caused by a large blocked vessel and a large area of brain damage. Participants receive either glenzocimab or a placebo as an intravenous inf…

Researchers are testing whether dapagliflozin, a daily oral drug, helps people with refractory heart failure who are on peritoneal dialysis remove more salt and fluid. The trial compares two 12-week periods: one with dapagliflozin added to usual care and one without. About 31 adu…

This study tests whether taking vitamin K2 supplements for one year can improve muscle strength and brain function in people who recently had an ischemic stroke. 190 participants will receive either vitamin K2 or a placebo daily. Researchers will measure handgrip strength and oth…

This study tests whether a 14-week elastic band exercise program can improve muscle mass, strength, and physical function in heart failure patients aged 50 and older who also have sarcopenia (age-related muscle loss). Researchers will measure changes in muscle, symptoms, and qual…

This trial tests whether combining foam sclerotherapy with a transdermal laser clears spider and reticular leg veins more effectively than foam alone. Researchers will enroll 70 women with these veins on both legs, treating one leg with the combination and the other with foam onl…

This study tests a digital program called TPA4You for older adults (50+) who care for a family member with heart failure. The program uses a Fitbit, video coaching, and text messages to encourage physical activity. The goal is to see if it's feasible and helps improve caregivers'…

This small pilot study will test a brief online mindfulness program (B-MORE) in 20 adults with high blood pressure and chronic stress. Participants attend two 60-minute virtual group sessions to learn stress management techniques. The study aims to see if the program is feasible …

This study tests a new medicine called ziltivekimab in 680 adults with heart failure and signs of inflammation. Participants will receive either the drug or a placebo for up to 16 months. The goal is to see if the drug improves heart failure symptoms and physical function, like b…

This study looks at the long-term safety and effectiveness of odevixibat in 70 people with Alagille syndrome, a rare genetic condition that affects the liver and other organs. The drug aims to reduce severe itching and improve bile flow. Participants who completed a prior 24-week…

Many Veterans with heart failure or COPD struggle with breathlessness, fatigue, depression, and anxiety that routine care often misses. This study tests whether a virtual team—a nurse and a social worker—can improve quality of life by helping Veterans manage their most bothersome…

This trial tests whether a structured therapeutic education program, delivered by general practitioners, can improve quality of life for people with heart failure. Around 200 patients in primary care will be randomly assigned to receive the program or usual care, and their qualit…

People on hemodialysis need their fistula punctured with a needle three times a week, which can be painful and anxiety-provoking. This trial compares three approaches: usual care, applying an ice pack to a specific point on the hand before the needle, and using a numbing gel. Res…

This trial tests whether wearing compression stockings with a higher (32 mmHg) or lower (21 mmHg) pressure after radiofrequency ablation for varicose veins leads to less pain and swelling. About 64 adults with varicose veins and leg swelling will wear one of the two stocking type…

This study follows 250 adults in the UK who already use rimegepant for migraine attacks. Over 12 weeks, they report how quickly the drug eases pain and other symptoms. The goal is to see how consistently rimegepant works in everyday life.

This study tests a new device called the EDEN system that records and classifies electrical signals from the heart during medical procedures. About 50 adults having heart procedures for ventricular arrhythmia or pacing will participate. The device works alongside standard equipme…

This study looks at whether insurance claims data can be used to reliably identify two serious complications in people with Alzheimer's disease: brain hemorrhages larger than 1 cm and new-onset seizures. Researchers will analyze records from 600 Alzheimer's patients, linking insu…

This study tests a personalized approach to find the best beta-blocker dose for older adults with heart failure. Fifty participants will either receive the N-of-1 intervention (testing different doses in 2-week cycles) or enhanced usual care. The goal is to see if this patient-dr…

This study will collect blood, urine, stool, and DNA samples from 2000 adults with heart failure to better understand how the disease progresses. Researchers will analyze proteins and other factors linked to declining heart function. Participants will be followed for up to 5 year…

This study tests whether a heart failure medication called Entresto (sacubitril/valsartan) can boost a natural hormone that helps control blood sugar after meals. Researchers will give the drug or a comparison drug (valsartan) to 25 adults with type 2 diabetes or prediabetes and …

This study looks at oxygen levels in the kidneys of premature babies born before 32 weeks who have a heart condition called patent ductus arteriosus (PDA). Researchers want to see how kidney oxygen relates to the severity of the heart condition and whether it can predict kidney i…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

Researchers are running an international registry to follow adults who had an ischemic stroke or transient ischemic attack and also have a patent foramen ovale, a small opening between the upper chambers of the heart. The registry collects real-world information on how these pati…

This study looks at whether detailed heart scans (echocardiograms and MRIs) can improve how doctors predict short-term risks in people with a type of high blood pressure in the lungs (pulmonary arterial hypertension). Researchers will follow 50 adults for 6 months to see if addin…

Researchers are comparing two ways of finding atrial fibrillation in people who have had an ischemic stroke or a transient ischemic attack (TIA). One method uses a standard electrocardiogram (ECG) in the hospital, and the other uses a prolonged cardiac monitor worn for a longer p…

This study looks at people with late-onset Pompe disease to measure antibodies against a virus used in gene therapy and against the standard enzyme replacement therapy. It also checks for biomarkers in blood and urine. About 119 teenagers and adults will give samples over 2 years…

This study explores whether artificial intelligence (AI) combined with data from a smartwatch can predict serious heart failure events, such as hospitalizations or worsening symptoms. Adults with heart failure will wear a smartwatch for six months and take weekly ECG readings. Th…

This study collects blood and other samples from people with sickle cell disease and healthy volunteers to help researchers understand how inflammation affects blood vessels. Up to 2,000 adults aged 18 and older will take part. The samples will be used in lab tests to support fut…

Researchers at Semmelweis University are studying whether bacteria that cause gum disease also show up in damaged blood vessels. They will compare samples from the mouth and from diseased artery sites in 100 people who need surgery for aortic aneurysm or carotid artery narrowing.…

Infective endocarditis is an infection of the heart's inner lining or valves. About half of patients need surgery during their hospital stay, while others receive antibiotics alone. Researchers are following 1,046 adults with confirmed endocarditis for up to 24 months to compare …

This study tests whether a simple educational guide can help postpartum patients who had high blood pressure during pregnancy become more active in their own care. Researchers will give the tool to some mothers shortly after delivery and compare their engagement scores with those…

This study tests a new computer-based visual training task for people who have lost part of their vision due to a stroke. Participants watch moving patterns on a screen and learn to detect motion direction, with the goal of improving visual abilities. The study first checks if th…

This long-term study follows over 3,700 adults in Baltimore to understand why some people age healthier than others. Researchers are looking at how race, income, and neighborhood affect risks for diseases like diabetes, heart disease, and memory loss. Participants visit mobile he…

This pilot study looks at biomarkers in the blood of people with fragile sarcolemmal muscular dystrophy, a condition that makes muscle membranes weak. Researchers will collect blood samples at rest and after exercise during four 5-day hospital stays. The goal is to better underst…

Researchers at the University of California, San Francisco, are studying whether the pace at which a woman's ovaries age can signal her future risk of heart disease. The trial follows 865 women who were already part of a long-running reproductive health study. Participants underg…

This pilot study is testing a device called LabClasp that measures blood sugar without needles. Researchers want to see if regular, non-invasive glucose checks can help predict gestational diabetes and preeclampsia in pregnant women. The study plans to enroll 100 women with at le…

This registry is collecting data from 20,000 people with coronary artery disease to see if an AI tool that analyzes CT scans of the heart can help doctors make better treatment decisions. The AI measures the amount and type of plaque in the arteries. Researchers will compare how …

This study explores whether an Apple Watch can track walking, heart rate, breathing, and sleep in people with glioblastoma, a serious brain cancer. The goal is to see if the watch can detect symptom changes before they become serious, like seizures or blood clots. Twenty-five pat…

This study aims to uncover the genetic roots of atrial fibrillation, a common heart rhythm disorder. Researchers are collecting blood samples and health data from 1,300 adults—some with the condition and some without—to compare their DNA. The goal is to identify genetic variants …

This study compared 50,000 living kidney donors to similar healthy non-donors to see if donating a kidney raises the long-term risk of heart attack, stroke, or death. Researchers looked at health records from 1992 to 2024 in three Canadian provinces. The goal is to help doctors a…

This study looks at how the common sweetener erythritol affects blood clotting and blood vessel health compared to aspartame. Twenty-four adults with a BMI of 27 or higher will drink beverages sweetened with each sweetener for two weeks. Researchers will measure markers of platel…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

Researchers at University Hospital Freiburg are studying how blood levels of hsCRP and Lp(a), two markers linked to heart disease, change over time in patients who have had these tests more than once. The study asks whether a high result on a first test often returns to normal la…

This study looks at whether having physical therapy (PT) and occupational therapy (OT) together in one session works as well as having them separately for stroke patients in the hospital. About 567 adults admitted for acute stroke will be randomly assigned to either co-treatment …

This registry will follow 3,500 adults with atrial fibrillation who have a low risk of stroke. Researchers will track complications like stroke and hospitalizations over time to see how patients are managed in everyday medical practice. The goal is to better understand outcomes a…

This study aims to understand how genes affect obesity, diabetes, and heart disease in people of African ancestry. Researchers will collect blood samples and health information from 1,100 adults, including African Americans, Afro-Caribbeans, and migrants from sub-Saharan Africa. …

Researchers are building a registry to follow adults with recurrent pericarditis, a condition where inflammation around the heart keeps coming back. The registry collects information over time on how often flare-ups happen, what treatments patients receive, and whether they are h…

This study tests whether a balloon device, called REBOA, can be safely used by emergency teams outside a hospital to improve blood flow in people whose heart has stopped (cardiac arrest). The balloon is inserted into the main artery and inflated to redirect blood to the heart and…

Researchers at Chungnam National University Hospital are studying blood and cerebrospinal fluid from adults who had an out-of-hospital cardiac arrest and received post-resuscitation care. The goal is to map molecular changes over time and see how they relate to the severity of br…

This Phase 1 trial investigates how the drug HRS-9057 is absorbed, processed, and eliminated in healthy men. Six participants receive a single dose, and researchers measure the drug and its breakdown products in blood, urine, and stool. The goal is to understand the drug's behavi…

Researchers in Finland are surveying about 2,000 adults who were treated for a stroke between 2020 and 2022 in two regions. The postal questionnaire asks about health, daily functioning, work and income, social inclusion, and experiences with social and health services. The goal …

This study looks at how common strokes and silent brain injuries are in young adults (ages 16-25) with sickle cell anemia, especially in Nigeria where the disease is widespread. Researchers will use brain scans and blood tests to check for damage and identify risk factors like hi…

This study looks at nearly 1,200 people with or at risk for pulmonary hypertension (high blood pressure in the lungs). Researchers use many advanced tests to find new ways to classify the disease and identify biomarkers. The goal is to better understand the disease and improve fu…

This study is an early-stage trial to check the safety of a new drug called RO7763505. It involves 196 participants, first in healthy volunteers and then in people with stable coronary artery disease. The main goal is to see if the drug is safe and how the body processes it, not …

This study is testing a new video game designed to help teenagers with congenital heart disease learn how to manage their own healthcare. The game teaches skills like talking to doctors, understanding medical information, and keeping track of appointments and medications. About 1…

This pilot study is testing whether it's possible to run a larger study that focuses on heart disease in women. Researchers will gather information from 176 women aged 25-55 in Ontario who have had certain female-specific health issues like pre-eclampsia, gestational diabetes, or…

This study enrolls adults aged 60 and older who are already participating in a larger trial comparing two ways to repair a leaky mitral valve. Researchers will use heart MRI scans, wearable heart monitors, and tissue samples to look for scarring in the heart muscle and abnormal h…

This study follows 121 adults who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring or cancer. Participants are monitored for up to 10 years with regular tests, scans, and occasional liver biopsies. The goal is to learn …

This study tests a training program that teaches doctors how to better talk with, listen to, and involve patients in their own care. About 180 doctors and their patients with high blood pressure will take part. The main goal is to see if the training is practical and acceptable, …

This study looks at how often nurses should check on people in the ICU after they have had a brain aneurysm treated. The goal is to see if checking every hour versus every two hours affects how well patients sleep. Thirty adults who had a planned aneurysm coiling will take part, …

This study looks at how common kidney injury is in newborns in intensive care and what factors increase the risk. Researchers will review medical records of about 4,000 babies from hospitals around the world. The goal is to better understand short- and long-term kidney health, bu…

This study follows over 1,000 adults who had their first stroke to see how many develop spasticity—a condition where muscles become stiff or rigid—within the first year. Researchers will monitor participants and create a best-practice guide for doctors to spot and treat this comm…

This study tests whether a machine-learning model can predict serious heart events in children admitted to the hospital. The model alerts doctors when a child may need a palliative care consultation. Researchers will compare outcomes before and after the model is used, involving …

This study monitors heart rate variability in 150 adults with type 2 diabetes who also have heart failure, chronic kidney disease, or both. Participants will wear a 24-hour heart monitor before and after starting a standard SGLT2 inhibitor medication. The goal is to understand ho…

This study looks at 500 women with chest pain to compare two tests used during heart catheterization—FFR and iFR—to see which better predicts future heart problems like heart attacks or strokes. Participants will be followed for 5 years. The goal is to improve how doctors decide …

Researchers in Uzbekistan are studying common respiratory and heart conditions in children from birth to age 15. They will analyze medical records and examine blood samples to understand immune and antioxidant function in affected children. The goal is to develop and test improve…

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study looks at whether tiny RNA particles called exosomal microRNAs in the blood can act as a 'stroke clock' for people with a severe type of stroke caused by a blocked large artery in the front of the brain. Researchers will compare blood samples from stroke patients to hea…

This study looks at how holding weights in the hands or arms changes the way people walk and how their trunk and hip muscles work. Researchers will ask adults aged 18 to 80 who are in cardiac rehabilitation to walk on a treadmill at different speeds, with and without extra weight…

This study looks at whether genetic differences affect how omega-3 supplements influence heart disease risk factors like cholesterol and blood pressure. Researchers are giving 200 healthy adults omega-3 capsules daily and measuring changes in blood lipids, blood pressure, and gen…

This study follows 20 newborns and children diagnosed with late-onset Pompe disease through newborn screening. Researchers will track their health for up to 4.5 years to document early muscle and joint symptoms, biomarkers, and quality of life. The goal is to learn when to start …

This observational study follows 95 people with heart failure and preserved ejection fraction who are already receiving weight loss treatment as part of their standard care. Researchers will measure muscle blood flow, fat content, and inflammation before and after at least 7% wei…

This study tests whether a clinical decision framework helps hospital doctors feel more confident when prescribing medications for older adults (65+) with chronic conditions like diabetes and high blood pressure. About 150 doctors will attend an educational session and complete s…

This study gathers health information from children under 18 who have cardiomyopathy linked to mutations in the MYBPC3 gene. Researchers aim to map the disease's natural course, identify risk factors, and measure how it affects quality of life. By reviewing past and future medica…

This study follows 120 stroke survivors for six months, using brain scans and movement tests to understand why some people develop arm stiffness and weakness. Researchers hope to find early signs that predict recovery, which could guide future rehabilitation. Participants must ha…

This study is collecting long-term, real-world data from about 6,000 adults being treated with Roche eye medications (Faricimab or the Port Delivery System with Ranibizumab) for conditions like wet age-related macular degeneration and diabetic macular edema. The goal is to unders…

This study tests whether artificial intelligence can accurately predict how patients recover after an ischemic stroke. Researchers will enroll 1000 adults from three European hospitals and use standard hospital data plus remote monitoring via a mobile app to train AI models. The …

Researchers at Fudan University are testing whether sitting in a 16°C room for two hours changes heart rate, blood pressure, lung function, or thinking speed in healthy young adults. Each participant will also spend time in a comfortable 22°C room for comparison. The study measur…

This observational study looks at how lowering body temperature during heart-lung bypass surgery affects two common brain monitors (BIS and PSI). Researchers will track 60 adults undergoing planned coronary bypass surgery. The goal is to see if the monitors' readings change diffe…

Researchers in Shanghai are testing whether breathing traffic-related air pollution during a short walk affects heart and lung function. Healthy young adults will either walk along a busy road or in a traffic-free park for 4.5 hours, alternating walking and rest. The team will me…

This study looks at two ways of managing anesthesia during non-intubated video-assisted thoracoscopic surgery (NIVATS), a type of chest surgery where patients breathe on their own without a breathing tube. Researchers will review records of 120 adults who had this surgery to crea…

Researchers at Fudan University are testing what happens to healthy young adults when they sit in a 32°C chamber for two hours. They will measure blood vessel stiffness, lung function, and mental speed, comparing these to a day spent at a comfortable 22°C. The study aims to revea…

This study tracks how paramedics use the ZOLL 731 ventilator when helping people with serious conditions like cardiac arrest, sepsis, or heart failure before they reach the hospital. Researchers will record which ventilator modes and settings are used, and how often alarms go off…

This study follows 200 adults in Western Denmark who are having a transcatheter aortic valve implantation, a procedure to replace a narrowed heart valve. Researchers will measure quality of life before the procedure and at follow-up using a standard questionnaire. They will also …

This study tests whether the pressure gradient across an intentionally created atrial septal defect, measured right after a minimally invasive mitral valve repair called M-TEER, can indicate how much mitral regurgitation remains. Researchers will compare this gradient with echoca…

This study looks at over 3,400 newborns who are not vigorous at birth (between 35 and 42 weeks). Doctors want to see if milking the umbilical cord (pushing blood into the baby) before clamping it leads to fewer cases of brain injury or death compared to clamping the cord right aw…

This study looks at how frailty, a measure of biological age, influences the care and outcomes of patients hospitalized with a heart attack. Researchers will analyze data from the Swedish SWEDEHEART registry, which includes information on thousands of patients. They will compare …

This 5-year study follows 250 people with von Hippel-Lindau disease who have brain or spinal cord tumors. Researchers use regular MRI scans and blood tests to see how fast tumors grow and what factors like hormones might affect growth. The goal is to better understand which tumor…

This study follows 250 people with high blood pressure and 60 healthy volunteers over several years. Researchers use heart imaging and blood tests to track changes in heart structure and function. The goal is to understand why some people with hypertension develop heart failure, …

This study looks at whether the body stores salt in the skin and muscles, and if that stored salt is linked to higher blood pressure. Researchers will compare healthy people with those who have hypertension, using MRI scans to measure salt content. They will also check if people …

This study is testing whether a wearable ECG patch, combined with AI analysis, can help doctors identify a wide range of heart conditions and risks from a single recording. The Cor360 system looks at many aspects of heart health at once, such as heart failure, rhythm problems, an…

This study is looking at people hospitalized for a heart attack (STEMI or NSTEMI) who undergo a procedure to open blocked heart arteries, called percutaneous coronary intervention (PCI) or angioplasty. It compares two groups: those having a standard (non-complex) PCI and those ha…

This study follows 5,000 people who recently had an ischemic stroke or a high-risk transient ischemic attack (TIA, often called a mini-stroke). The goal is to see how well standard post-stroke care works in the real world and to track patients' health and quality of life for up t…

This observational study will enroll about 8,000 adults across Europe who have coronary heart disease or are at high risk for it, including those with diabetes or chronic kidney disease. Researchers will check whether doctors are following European guidelines for lifestyle advice…

This observational study aims to capture a real-world snapshot of how heart failure is managed across Europe and worldwide. Researchers will collect data from about 4,000 adults with chronic or acute heart failure, looking at whether routine care aligns with the 2021 ESC guidelin…

This study looks at whether a disrupted sleep-wake cycle is linked to higher blood pressure and poorer heart health in young adults aged 18 to 45 with high blood pressure. Participants wear a wrist monitor for 14 days, have their blood pressure tracked for 24 hours, and complete …

This study looks at children who had hypoxic-ischemic encephalopathy (HIE) at birth, a condition caused by lack of oxygen to the brain. Researchers want to see if combining MRI scans taken shortly after birth with scans taken at school age can better predict cognitive outcomes li…

This study follows about 5,000 people with coronary artery disease who are treated with a paclitaxel drug-coated balloon angioplasty, a procedure that opens narrowed heart arteries and releases medication to help keep them open. Researchers are combining past medical records with…

This study is developing a digital twin—a virtual model of the heart and blood vessels—to better understand and manage hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. Researchers will gather detailed health data from 2500 people with HCM or the gen…

This study follows 500 adults under 45 who have narrowing of a major brain artery, a condition that can raise stroke risk. Researchers will track participants over time to see how the narrowing progresses and who goes on to have a stroke. The goal is to better understand the natu…

This study looks at whether measuring the arm or finger can help choose the right blood pressure cuff size for pregnant women. Accurate blood pressure readings are vital during pregnancy and childbirth, but the current method of sizing cuffs may not always be correct. Researchers…

People recently released from prison face twice the risk of dying from heart disease compared to the general population. This study investigates the barriers and facilitators to healthcare access for this group, following 508 adults released from state prison in the Denver/Aurora…

This study looks back at 10 years of medical records from a scoliosis referral center to see how frequently adults with scoliosis who had surgery also develop restrictive breathing problems or signs of pulmonary hypertension on echocardiography. By analyzing data from 174 patient…

This study investigates whether people with neurodegenerative diseases—like Alzheimer's, Parkinson's, or ALS—show changes in behavior, social circumstances, or health before and after their diagnosis. Researchers will compare the records of over 61,000 patients with those of matc…

This study looks at whether sensors inside implanted heart devices can warn of worsening heart failure. Researchers will track 500 adults with heart failure or cardiomyopathy who have a Boston Scientific ICD or CRT-D equipped with HeartLogic, Sleep Incline, and Apnea Scan functio…

This study follows 60 people with abdominal aortic aneurysm who are scheduled for endovascular repair (EVAR). Researchers will measure artery stiffness, heart structure and function, and certain blood markers before the procedure and at several points afterward. The goal is to un…

This registry follows 500 people receiving a specific type of surgical aortic valve replacement (the INSPIRIS RESILIA valve) for up to five years. Researchers are tracking how pre-existing conditions like kidney disease, diabetes, and high blood pressure affect survival and valve…

This study tests whether a new scoring system, called PRO-ICH, can accurately predict how well people will recover after a spontaneous brain hemorrhage. Researchers will also check if adding certain blood markers improves the score's accuracy. The goal is to give doctors a reliab…

This trial tests whether wearable devices can measure how the body responds to everyday challenges like changes in salt intake, meals, fasting, and exercise in adults with endocrine or metabolic disorders. Participants wear home monitoring devices and follow different diet and ac…

This study follows about 400 adults with liver cirrhosis admitted to internal medicine wards across Italy. Researchers will track how doctors manage hepatic encephalopathy—a brain complication of liver disease—during hospitalization and after discharge. The goal is to identify pr…

This study explores whether a special 3D ultrasound technique, called vector flow imaging, can predict where blood clots form inside abdominal aortic aneurysms. Researchers will scan 14 people with small aneurysms (under 5.5 cm), half with existing clots and half without. They wi…

This study examines genetic test results from over 600 people who had acute myocarditis (heart muscle inflammation) confirmed by MRI. Researchers want to find out how common certain gene variants are in this group and whether they are linked to worse outcomes like heart failure o…

This study aims to better understand atrial fibrillation (AFib), the most common abnormal heart rhythm. Researchers will use mobile devices like ECG patches and a smartphone app to monitor heart rhythm, activity, and sleep in 3,000 adults, some with AFib and some without. Partici…

This observational study looks at how inserting a central venous catheter into the neck affects pressure inside the skull in patients with acute brain injury. Researchers will monitor brain pressure, blood flow, and oxygen levels during and after the procedure in about 120 ICU pa…

This pilot study looks at whether spinal cord stimulation can improve nerve health in people with small fiber neuropathy, a condition that causes chronic pain. Researchers will measure changes in nerve fiber density from skin biopsies taken before and after 12 months of routine c…

This study investigates how people physically interact with each other during tasks like collaboration, competition, and cooperation. The goal is to design robot controllers that mimic these human behaviors, which could then be used in devices like exoskeletons to improve motor l…

This study scans over 16,000 adults aged 18 to 70 without known heart disease to find hidden (silent) plaque in their arteries using ultrasound and CT scans. The goal is to measure how common silent atherosclerosis is and build a risk calculator that combines imaging, lifestyle, …

This study collects blood and tissue samples from up to 500,000 adults, including heart patients, their family members, and healthy individuals. Researchers will analyze these samples to find molecular and genetic markers linked to heart disease. The goal is to improve understand…

This study uses a non-invasive ultrasound device to monitor blood flow and detect tiny clots traveling to the brain during placement of a specialized stent-graft for thoracic aortic aneurysms or dissections. Researchers aim to understand how often these microemboli occur and how …

This pilot study investigates whether a continuous remote ECG monitor, worn as a chest patch, can predict hospital readmission or death within 30 days after discharge in patients with heart failure and atrial fibrillation. Fifty participants will wear the Vivalink ECG patch at ho…

This study looks at whether detailed analysis of heart MRI images (called radiomics) can better predict life-threatening heart rhythms in people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. Researchers will also see if the drug mavacamten, …

This study follows 172 adults over two years to compare cardiovascular function among four groups: vapers who previously smoked, vapers who never smoked, people who both vape and smoke, and ex-smokers who do not vape. Researchers measure blood vessel health, lung function, and bl…

This study uses a new, child-friendly brain imaging technique called OPM-MEG to understand how immune-related brain diseases (like autoimmune encephalitis and multiple sclerosis) and other brain conditions affect children aged 2 to 25. Standard scans often miss problems with memo…

This trial investigates whether kidney transplant candidates on dialysis can safely skip routine heart screening after being placed on the waiting list. Participants are randomly assigned to either no further screening or regular annual screening for hidden coronary artery diseas…

This study looks for biological markers in the blood and tissue of adults with Marfan syndrome that could signal when an aortic aneurysm is dangerous enough to require surgery. Researchers will compare three groups of Marfan patients: those without aortic aneurysms, those with st…

This study follows 250 people who had a type of stroke called intracerebral hemorrhage (ICH) to understand why some experience progressive cognitive decline. Participants undergo advanced brain scans and tests of thinking and movement at 12–24 months after their stroke, with foll…

This trial investigates whether measuring high-sensitive troponin, a protein released during heart injury, can predict heart complications in people undergoing surgery to open a narrowed carotid artery. About 527 participants will have their troponin levels checked before and aft…

This study follows 100 people with and without varicose veins to see how often the condition appears and how it changes over time. Participants get yearly checkups including ultrasound exams. The goal is to learn what factors make vein disease worse and how it naturally progresse…

This study follows over 3,400 adults who have had a heart stent procedure to understand how continuity of care, health literacy, and medication adherence influence their long-term health. Researchers will track hospital readmissions, medication use, and patient-reported outcomes …

This study tests whether a newer, less invasive heart-lung machine (MiECC) reduces brain swelling and stroke risk compared to the standard machine used during open heart surgery. Researchers will measure optic nerve sheath diameter (a marker of brain pressure) and track strokes o…