Cardiovascular disorder

Newborns who suffer a stroke or oxygen loss around birth can develop cerebral palsy and other lifelong disabilities, and no treatment can repair the damage. Researchers at UMC Utrecht are testing whether a single dose of bone marrow-derived mesenchymal stromal cells, sprayed into…

This study tests a minimally invasive procedure called SESAME for people with thickened heart muscle that blocks blood flow from the heart. The procedure uses a catheter to make a controlled slice in the muscle, aiming to relieve symptoms like shortness of breath. Researchers wil…

Kaiser Permanente researchers are testing whether digital outreach helps adults with heart failure refill medications they have let lapse. Participants are assigned to receive either interactive text messages or automated phone calls encouraging refills, or usual care with no ext…

This trial tests a medical device that has not been approved or cleared by the U.S. FDA. Researchers want to learn whether the device is safe and whether it can help people with a specific condition. Participants receive the device as part of the study, and the team monitors thei…

Researchers are testing whether adding finerenone to standard heart failure care can protect heart function and prevent worsening heart failure in people with heart failure with preserved ejection fraction (HFpEF). The trial enrolls adults with HFpEF who are randomly assigned to …

Researchers are running a Phase 3 trial to see whether hydroxychloroquine or corticosteroids can reduce heart valve damage in children and young people with acute rheumatic fever. The trial enrolls about 600 participants aged 4 to 25 who are hospitalized with confirmed valve infl…

This trial tests whether a drug called carfilzomib, given directly to the liver through an implanted pump, is safe for people whose colon, adrenal, or bile duct cancer has spread to the liver and persists after prior pump therapy. Participants receive weekly infusions of the drug…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

Researchers are testing resmetirom, an oral drug, in adults who have metabolic dysfunction-associated steatohepatitis (MASH) and heart failure with preserved ejection fraction (HFpEF). The trial assigns participants to receive resmetirom or a placebo for 24 weeks. The main goals …

This study tests whether stroke survivors can safely use a robot called ReHandyBot to exercise their hand at home without a therapist present. Participants first learn how to use the device at a clinic, then take it home to train on their own. The goal is to see if unsupervised h…

Researchers are comparing a drug-coated balloon procedure plus intensive medical care against intensive medical care alone in people with severely narrowed brain arteries that have caused stroke or mini-stroke symptoms. The trial enrolls 570 adults aged 18 to 80. Everyone receive…

Researchers are testing an experimental drug called YMI024 in adults with stable coronary artery disease and high levels of a blood marker of inflammation called hsCRP. The trial assigns about 180 participants to one of five doses of YMI024 or a placebo, with neither participants…

Researchers are testing whether an educational and implementation tool helps hospitals follow best-practice guidelines for preventing second strokes caused by heart conditions. The trial enrolls about 2,400 patients who have had an ischemic stroke or a transient ischemic attack. …

Researchers are testing whether seltoplasmid, a gene therapy injected into the calf muscle, can improve outcomes for people with type 2 diabetes who have poor blood flow to the foot and a non-healing ulcer. All participants first undergo a standard procedure to restore blood flow…

Researchers are studying depemokimab, an injected biologic drug, in adults aged 18 to 75 who have allergic bronchopulmonary aspergillosis (ABPA) along with severe eosinophilic asthma. The study tracks how many asthma attacks need systemic steroids and whether participants' qualit…

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

This trial tests whether treating high blood pressure in pregnancy to a stricter target (below 140/90) is better than the usual approach (below 160/110) for women with gestational hypertension or preeclampsia without severe features. About 4,120 pregnant women will be randomly as…

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

Researchers are testing whether a standardized care pathway helps adults with advanced heart failure in Latin America complete a multidisciplinary evaluation and receive a documented treatment decision within 90 days. The trial includes 360 adults with acquired or structural hear…

This study tests whether the drug telaglenastat, taken twice daily for 12 weeks, can safely lower blood pressure in the lungs and improve heart and lung function in adults with pulmonary hypertension. About 28 participants will receive the drug on top of their usual care. The mai…

This study tests a new imaging and guidance system called VERAFEYE that creates a 3D model of the heart to help doctors navigate during catheter ablation for atrial fibrillation. About 50 adults with paroxysmal or persistent atrial fibrillation will have their standard ablation p…

This study tests a program for new mothers who had high blood pressure during pregnancy. Participants wear a FitBit and receive weekly messages with personalized activity goals. The goal is to see if this approach increases daily steps and improves blood pressure, and whether mom…

Adults with a secundum atrial septal defect (a hole in the heart) who are scheduled for device closure receive either dapagliflozin or a placebo for six months. Researchers use advanced echocardiography to measure how well the right side of the heart recovers and reverses its enl…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

Researchers are testing whether a lower dose of the clot-dissolving drug alteplase can treat life-threatening pulmonary embolism as effectively as the standard full dose while causing less severe bleeding. The trial enrolls adults with acute high-risk pulmonary embolism, a condit…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests whether a virtual team of clinical pharmacists and cardiologists can help doctors prescribe the right heart failure medications for Veterans. Many patients do not receive all recommended drugs at effective doses after a hospital stay. The team reviews patient rec…

This study tests whether a citrate-based dialysis fluid with extra magnesium can slow or prevent blood vessel hardening in adults on long-term hemodialysis. Eighty stable patients will receive either the new fluid or a standard one for 12 months. Researchers will measure blood ma…

Researchers are testing whether a standardized automated blood pressure measurement protocol in Australian general practice clinics improves hypertension control among adults. The protocol uses a validated device that takes several readings automatically after a five-minute rest,…

This pilot study tests a procedure called left atrial appendage occlusion (LAAO) using the Watchman Flx PRO device in 40 dialysis patients with atrial fibrillation. The goal is to see if it safely reduces stroke and major bleeding compared to standard care. Participants will be f…

This study compares two treatments for when a leg artery stent narrows again (in-stent restenosis). About 578 patients will receive either a drug-coated balloon or a drug-eluting stent, both of which release medication to keep the artery open. The goal is to see which approach re…

This study tests whether using a 21-question tool to understand a person's daily habits, then giving tailored advice, can lower blood pressure more than routine counseling. Researchers will compare two groups of adults with hypertension over three months. The goal is to see if pe…

This observational study is looking at whether Ferretab comp., an oral iron and folic acid supplement, can improve anemia and heart-related symptoms in adults who also have coronary artery disease or heart failure. Participants take the supplement for 12 weeks as part of their us…

Researchers are studying how heart arteries change after a blocked vessel is opened with a paclitaxel drug-coated balloon instead of a metal stent. The balloon delivers a drug to the artery wall and then is removed, leaving no permanent implant. About 150 adults who had this proc…

Researchers are testing whether adding a PCSK9 inhibitor to standard statin therapy can stabilize vulnerable plaques in the carotid artery, the main blood vessel to the brain. The trial enrolls 120 adults with carotid narrowing and high-risk plaque features. Participants receive …

This study tests a new device called the VERAFEYE System, which creates a 3D model of the heart to guide doctors during catheter ablation for paroxysmal atrial fibrillation (a type of irregular heartbeat). About 100 adults who are already scheduled for ablation will have the proc…

This study explores whether measuring a hormone called renin can help doctors choose the best first medication for people with early-stage high blood pressure. Adults with low renin levels are randomly assigned to receive either spironolactone or a standard blood pressure drug fo…

Researchers are testing the FARAFLEX Mapping and Pulsed Field Ablation System in people with atrial fibrillation who need a repeat ablation procedure. The trial compares the FARAFLEX system, which uses electrographic flow mapping and pulsed electric fields, against a control trea…

Researchers are testing a medical device that has not been approved or cleared by the U.S. FDA. The trial aims to see whether the device can help control a disease, possibly by reducing symptoms or slowing its course. Participants receive the device as part of the study, and the …

This study tests whether a tablet-based brain training program and/or a powerful cholesterol-lowering drug (PCSK9 inhibitor) can improve thinking and memory in 420 adults aged 55-80 with narrowed brain arteries. Participants will be split into four groups, combining or not combin…

This study looks at how well the drug Jardiance works compared to other standard heart failure treatments in Chinese patients with a specific type of heart failure (HFrEF). Researchers will track about 5,000 adults to see which treatment better prevents heart failure hospitalizat…

Researchers compare two approaches for adults with small unruptured brain aneurysms found by chance: regular imaging surveillance without initial treatment, or immediate endovascular or surgical repair. The trial enrolls 600 adults aged 35 to 75 with aneurysms measuring 2 to 7.9 …

This study tests an experimental oral drug called AC01 in 400 people with chronic advanced heart failure and a weak heart pump. The goal is to see if AC01 can safely improve heart function over 12 weeks compared to a placebo. Participants will have heart ultrasounds and blood tes…

This study tests a new drug called EPN-701 for calciphylaxis, a rare condition causing painful skin sores with no approved treatment. About 60 adults with moderate to severe pain and at least one open sore will receive the drug. The main goals are to see if EPN-701 safely reduces…

Many people live with heart disease, kidney disease, and type 2 diabetes at the same time, but care often focuses on each condition separately. This trial tests a primary care model that brings these conditions together under one coordinated plan. Primary care centers receive tra…

Researchers test whether adding superior vena cava isolation to standard pulmonary vein isolation helps people with persistent atrial fibrillation. About 340 participants aged 18 to 75 whose AFib has lasted less than a year and who are having their first catheter ablation join th…

Researchers are testing an experimental eye injection called GenSci148 in people with neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO). GenSci148 is a fusion protein designed to block four proteins involved in blo…

Researchers are testing whether adding tirofiban to standard antiplatelet therapy improves recovery for people whose ruptured brain aneurysm is repaired with a stent. The trial enrolls adults with acute subarachnoid hemorrhage who receive stent-assisted coiling within 72 hours of…

This pilot study tests whether giving semaglutide (Ozempic) to 100 stroke patients who had a clot-removal procedure can improve recovery. Patients are randomly assigned to receive weekly injections for 12 weeks or no drug. The main goal is to see if a larger, definitive trial is …

Researchers are testing whether trametinib, an FDA-approved cancer drug, can help infants with RASopathies who have a severe, life-threatening heart condition called hypertrophic cardiomyopathy. The trial enrolls about 25 babies with a confirmed genetic diagnosis. Participants re…

This study tests whether combining a gentle nerve stimulation device worn on the ear (taVNS) with intensive arm therapy (CIMT) can help infants and toddlers (8–24 months) with perinatal brain injury improve movement in their weaker arm and hand. The therapy involves placing a mit…

Researchers are testing whether a drug-coated balloon alone can keep heart arteries open after clearing a chronic total blockage, without leaving a permanent metal stent. The study plans to enroll 38 adults with a long-standing coronary occlusion and angina or documented ischemia…

Researchers compare two timing strategies for the Impella CP heart pump in people who have a heart attack and develop cardiogenic shock, a dangerous state where the heart cannot pump enough blood. One group receives the pump before the artery-opening procedure called PCI, while t…

Researchers are testing an experimental oral drug called MN-08 in healthy adults to see how safe and tolerable it is. The trial gives participants either MN-08 or a placebo for about a week and measures side effects, vital signs, heart rhythm, and blood test changes. It also trac…

This study looks at people with a rare lung condition called CTEPH who have done well after a procedure (balloon angioplasty) and are taking a drug called riociguat. The goal is to see if stopping the drug is as safe as continuing it. About 150 participants will be randomly assig…

Researchers are testing an experimental antibody called SZN-8141 in people with diabetic macular edema, a swelling of the retina that can blur vision. About nine participants will each receive a single injection of SZN-8141 into the eye, with small groups getting increasing doses…

Researchers in Denmark are testing whether a structured weight loss program can slow the progression of atrial fibrillation in people who are overweight or obese. The trial enrolls 480 adults with symptomatic paroxysmal or early persistent atrial fibrillation and a body mass inde…

This registry will follow 2000 people with complex coronary artery disease who receive the Inspiron EVO drug-eluting stent. The stent is designed to be easier to deliver and stronger than standard stents. Researchers will track how well the stent works and whether it reduces hear…

This trial explores whether a single, low-dose radiation treatment to the heart can improve pumping function in people with advanced or end-stage heart failure. The study includes 20 adults with severe heart failure who are not eligible for a transplant or mechanical heart pump. …

This trial tests whether adding nicorandil, a drug that widens blood vessels, to standard rheumatoid arthritis (RA) treatment can reduce the buildup of plaque in arteries. People with RA have a higher risk of atherosclerosis, which can lead to heart attacks and strokes. Researche…

This early-phase trial is testing a new cell therapy called GT719 for several immune-mediated kidney diseases, including IgA nephropathy and membranous nephropathy. The therapy uses specially engineered immune cells to target and potentially control the disease. The study will en…

This study tests whether two heart failure medications, dapagliflozin and spironolactone, can help the heart recover better after aortic valve replacement. About 445 adults with severe aortic stenosis will take one or both drugs daily for 12 months. The goal is to see if these me…

This trial tests whether a sirolimus-coated balloon, guided by intravascular ultrasound, works as well as a standard drug-eluting stent for people with acute coronary syndrome and large-vessel heart blockages. Participants are randomly assigned to receive either the balloon witho…

Researchers are testing whether adults with obstructive hypertrophic cardiomyopathy can safely taper off beta-blockers after their heart condition has stabilized on mavacamten. The trial enrolls 286 people aged 18 to 75 who have been on a stable dose of mavacamten and one beta-bl…

Researchers test whether a digital care pathway app plus non-real-time messaging with a nurse helps adults in primary care lower their systolic blood pressure. About 600 patients with uncontrolled hypertension receive usual care, usual care plus the app, or usual care plus the ap…

This trial tests whether adding laser therapy to standard gum surgery improves treatment of advanced periodontitis. Adults with stage I to III periodontitis who still have deep pockets after initial non-surgical care will receive open flap debridement, a procedure that lifts the …

This study looks at people with atrial fibrillation (an irregular heartbeat) who have already had a successful mitral valve repair. It compares two approaches: catheter ablation (a procedure to fix the heart's electrical signals) versus standard medical care. The goal is to see i…

This study tests whether using a heart pump (Impella 5.5) along with standard heart failure medications can help people with severe heart failure and shock recover without needing a heart transplant or permanent artificial heart. About 250 adults with weak hearts (ejection fracti…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

Researchers are testing an experimental treatment called AB126, made from neural exosomes, in adults who have had a moderate to severe acute ischemic stroke and who showed limited improvement after a procedure to clear the blocked blood vessel. The trial aims to find out whether …

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This trial tests whether the anesthetic remimazolam keeps blood pressure more stable than the standard drug propofol in adults undergoing surgery to repair an aortic aneurysm. Maintaining steady blood pressure during these procedures helps protect vital organs. Researchers will m…

This phase 3 trial is testing whether an experimental drug called BHB-1893 works better than the standard beta-blocker metoprolol for adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM), a condition where the heart muscle thickens and blocks blood flow. The stu…

This platform trial will enroll 1,000 adults with heart failure to test several different treatments at the same time. Participants are randomly assigned to either an experimental intervention or standard care. The main goal is to see if these treatments can prevent death or hosp…

Some newborns with HIE, a brain injury from lack of oxygen at birth, also develop heart problems. This pilot trial tests whether starting a heart medication called dobutamine early, before heart failure signs appear, is feasible and safe. Forty babies receiving cooling therapy wi…

This early-stage study tests whether it is safe to take nitroglycerin spray (used for chest pain) together with an experimental drug called nurandociguat (designed to help kidneys) in 36 adults with stable coronary artery disease. Both drugs widen blood vessels, so the main conce…

The RELEASE trial tests whether adults aged 65 and older with stable ischemic heart disease can safely stop their daily low-dose aspirin. Researchers will compare stopping aspirin against continuing it in 7,000 participants who have been free of heart events for at least two year…

This trial tests whether adding Yiqi Fumai lyophilized injection to standard heart failure treatment improves symptoms and reduces heart strain in adults with chronic heart failure caused by coronary heart disease. About 100 participants at four hospitals in China will receive th…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This 52-week trial tests whether combining a structured lifestyle program with a mushroom-based supplement and the drug bupropion helps overweight adults lose weight and lower cardiometabolic risk. About 250 adults aged 18 to 55 with a BMI between 25 and 35 will be randomly assig…

This study tests whether adjusting the dose of mavacamten based on heart pumping strength can further reduce the blockage of blood flow in people with obstructive hypertrophic cardiomyopathy. Participants are adults who have been on a stable mavacamten dose for at least 12 weeks …

This pilot study tests whether giving new mothers with preeclampsia or gestational hypertension a blood pressure cuff, extra education, and a reminder bracelet helps them manage their blood pressure at home. About 40 participants will receive these tools before leaving the hospit…

This study tests whether using a patient's genetic information to choose anti-platelet drugs can lower bleeding risks compared to standard care. About 1,760 high-risk patients receiving a heart stent will be assigned to either a personalized drug plan or usual therapy. The goal i…

This trial tests a new heart valve called the INOVARE SAFESYNC, which doctors implant through a tube in the leg, avoiding open-heart surgery. The study enrolls 40 people with severe aortic stenosis, a narrowing of the heart's main valve, who are at intermediate or higher risk for…

This trial tests whether a 12-week remotely supervised exercise program can improve recovery in adults aged 50 to 75 who had catheter ablation for atrial fibrillation. Participants are randomly assigned to either the telerehabilitation group, which does aerobic, strengthening, an…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study tests whether a nurse-led, community-based program can help lower blood pressure in adults aged 25 and older with uncontrolled hypertension in Monrovia, Liberia. Trained community health nurses provide medication and lifestyle counseling at mobile clinics in high-traff…

This study tests whether combining non-invasive light therapy on the head, electrical stimulation cycling for the arms, and cognitive tasks can improve thinking and arm movement in adults who have had a stroke. Participants attend 10 sessions over 2 weeks, and researchers measure…

This trial tests whether giving naloxone during CPR helps people who have a cardiac arrest in the hospital. Naloxone is a drug that blocks opioid effects, and researchers want to see if it improves survival and recovery. About 850 adults who receive adrenaline during CPR will be …

Peripheral artery disease can completely block the superficial femoral artery in the thigh, cutting off blood flow to the leg. This trial tests a minimally invasive procedure that uses a rotating device to shave away the blockage, followed by a drug-coated balloon to widen the ar…

This study tests whether a minimally invasive heart valve repair procedure (TEER) plus standard medication can reduce hospital readmissions over two years in people with moderate mitral regurgitation that worsens with exertion. About 300 participants will be randomly assigned to …

This trial tests a 'Hospital-to-Home' support program for people recovering from acute coronary syndrome, a group of heart emergencies like heart attacks. Participants are randomly assigned to either the structured program or standard education. The program uses behavior change m…

This early trial tests a new device called Anchord that repairs leaky mitral valves without open-heart surgery. It will include 5 people with severe valve leakage who are too high-risk for standard surgery. The goal is to see if the device is safe and can reduce the leak, improvi…

This study tests whether adding a preventive procedure called pulmonary vein isolation (PVI) to the standard ablation for typical atrial flutter can reduce the risk of heart-related hospital visits, stroke, or death. The trial enrolls adults aged 55 and older with an enlarged lef…

This trial tests whether giving adolescent girls a daily multiple micronutrient supplement (with or without extra nutrients) improves their growth, brain function, bone health, and overall well-being compared to the standard weekly iron-folic acid pill. About 3,000 girls aged 10–…

This trial investigates whether adding early lumbar drainage to standard care (a drain in the head plus clot-dissolving medication) improves long-term outcomes for people with bleeding into the brain's fluid-filled spaces. The study includes adults aged 18 to 85 who have had a fi…

This trial studies people with pulmonary arterial hypertension (PAH) who live permanently above 2600 meters. Researchers want to see if spending one week at sea level and then returning to high altitude changes pressure in the lung's blood vessels. They will measure heart and lun…

This trial tests two ways of placing a pacemaker lead in the heart's left bundle branch area. One strategy aims to directly capture the heart's conduction system, while the other accepts capture of the nearby septal muscle. Researchers will compare how well the heart's pumping fu…

This trial tests whether a small leadless pacemaker, the Aveir VR, can be safely implanted through the jugular vein in the neck instead of the usual route. Researchers will enroll 15 adults with slow heart rhythms who need ventricular pacing. The main goal is to see if the proced…

This study tests whether medically tailored meals, prepared to support kidney and heart health, can improve blood pressure and kidney function in Veterans with chronic kidney disease. About 100 participants will be randomly assigned to receive these meals or usual care for three …

This trial tests whether a granule form of the Chinese herbal formula Huayu Jiedu (FTFY-919) works as well as the traditional decoction for people with acute hypertensive intracerebral hemorrhage, a type of stroke caused by bleeding in the brain. About 300 adults who have had a b…

This trial tests whether a procedure to reopen a blocked carotid artery in the neck can improve cognitive function in people who have had a stroke or mini-stroke and now have thinking or memory problems. Participants are randomly assigned to receive standard medical care alone, o…

This trial tests whether treadmill training with a robotic cable that gently pulls walkers side-to-side can improve balance and daily walking in adults who had a stroke. Participants complete 20 high-intensity treadmill sessions, either with the robotic pulling forces or without …

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This trial tests whether an 8-week home-based telerehabilitation program, delivered through a mobile app, can safely improve exercise capacity in adults with pulmonary arterial hypertension (PAH). PAH causes severe shortness of breath and fatigue, and many patients cannot easily …

This trial tests a structured care pathway called TORCH-ITAP in Latin America. The pathway standardizes how patients with congenital heart disease are identified, referred, evaluated, and matched for heart or lung transplants. Researchers will compare hospitals using the pathway …

This pilot study tests whether putting back a child's own thymus tissue during heart surgery is safe and helps support the immune system. In some congenital heart disease surgeries, the thymus is removed to reach the heart, which may weaken immunity. Researchers will compare chil…

This pilot study tests whether stroke survivors can follow a self-managed exercise program at home to maintain their health. Participants first complete an 18-session guided program with respiratory, strengthening, and cardiovascular exercises, plus weekly virtual coaching sessio…

This study tests a new, simple procedure done right after doctors remove a blood clot from the brain in severe stroke patients. The procedure involves briefly inflating and deflating a tiny balloon to gently restore blood flow, which may prevent extra brain damage. About 288 to 4…

This trial tests whether a newer ventilation method, called flow-controlled ventilation, keeps the lungs and diaphragm in better shape than the standard pressure-controlled method during elective heart bypass surgery. About 154 adults scheduled for on-pump coronary artery bypass …

This study compares two methods to remove large blood clots from the brain during a stroke: using a super large suction catheter versus a stent retriever. About 708 adults with acute ischemic stroke will be randomly assigned to one of the two techniques. The goal is to see which …

This trial tests whether starting a powerful cholesterol-lowering combination right after a heart attack can make the fatty plaques in coronary arteries more stable. Researchers will compare an early intensive strategy using a high-intensity statin, ezetimibe, and inclisiran agai…

This trial tests whether empagliflozin, a drug used for diabetes, improves blood vessel and nerve function in adults aged 45 to 75 with prehypertension. Participants take the drug or a placebo for two weeks, then switch, while a control group with normal blood pressure is observe…

This trial tests whether mazdutide, a weekly injection that targets GLP-1 and glucagon receptors, can safely reduce portal pressure in overweight adults with compensated cirrhosis and clinically significant portal hypertension. Participants receive 16 weeks of mazdutide, with the…

This study tests a stent (Carotid WALLSTENT) used with a special brain protection system (ENROUTE NPS) in 60 Chinese patients with narrowed carotid arteries. The goal is to see if the combination can be safely delivered to prevent strokes. Patients must have significant artery na…

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people who have had a brain hemorrhage (a type of stroke) recover better and avoid future heart attacks or strokes. About 1,125 adults with signs of artery disease will take either colchicine or…

This trial studies people with pulmonary arterial hypertension, a condition where high blood pressure strains the lungs, who live permanently above 2600 meters. Researchers test whether spending one week at sea level and then returning to altitude changes how far participants can…

This trial tests whether a coordinated care team, including cardiologists, pharmacists, dietitians, and rehabilitation specialists, can improve outcomes for people hospitalized with heart failure with preserved ejection fraction (HFpEF). Participants receive structured follow-up,…

This pilot study tests whether endoscopic sleeve gastroplasty (ESG), a minimally invasive procedure that reduces stomach size, can help obese adults with heart failure with preserved ejection fraction (HFpEF). Researchers will measure changes in heart failure symptoms and weight …

This study will look at how well a drug called ARNi (sacubitril/valsartan) lowers blood pressure in 500 adults with hypertension in the United Arab Emirates. Researchers will compare it to standard treatments like ACE inhibitors and calcium channel blockers. The goal is to see if…

This study tests an experimental drug called HRS-1780 in people with uncontrolled or resistant hypertension—high blood pressure that stays high despite treatment. The trial compares three different doses of HRS-1780 against a placebo to see if it safely lowers blood pressure. Par…

This study tests a medicine called tenecteplase for people who have a stroke but don't know exactly when it started, like waking up with symptoms. About 352 adults will get either tenecteplase or standard care after a simple CT scan. The goal is to see if the drug helps them reco…

This study compares two blood thinners—apixaban (Eliquis) and warfarin (Coumadin)—in 460 people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to see which drug better prevents strokes, pump clots, and serious bleeding. Participants must have had their…

This trial tests whether a new scoring system, called the Biological Congestion Score (BCS), can help doctors better manage diuretic medications in people with chronic heart failure. The BCS combines four blood biomarkers with clinical information to estimate fluid congestion and…

This trial tests a small device called the C-MIC System, which is implanted under the skin and delivers a constant low-level electrical current to the heart. The goal is to see if this microcurrent can improve heart pumping ability, exercise capacity, and quality of life in peopl…

This pilot study is testing whether a Bifidobacterium probiotic supplement can help lower blood pressure in 30 middle-aged Chinese adults with untreated hypertension. Participants will take the probiotic for 12 weeks, and researchers will monitor their blood pressure and other he…

This trial compares two ways of placing a pacemaker lead in people who develop a slow heart rhythm after cardiac surgery. One method uses conventional right ventricular pacing, while the other uses left bundle branch area pacing, which aims to activate the heart more naturally. T…

This trial compares two types of replacement heart valves used in a procedure called TAVI for people with severe aortic valve stenosis and a small aortic annulus. The two valves are the Meril Octapro+ and the Abbott Navitor. Researchers want to see which design provides better sa…

This study tests a brain-computer interface called BrainGate2 in people with expressive aphasia, a condition where stroke damage makes it hard to speak. Researchers place small sensors in the brain areas that control speech, then record brain activity while participants try to sp…

This study tests a new non-invasive brain stimulation method that targets deep brain structures through the scalp, without surgery, to improve arm and hand function in people who had a stroke at least 12 weeks ago. Participants receive either active stimulation or a sham version,…

This trial tests a support program for adults with glaucoma who struggle to take their eye drops regularly or attend clinic visits. Participants identify their main barrier, such as forgetfulness or difficulty using drops, and receive matching help like education, reminders, or t…

This trial tests whether a daily supplement combining sacha inchi oil and coenzyme Q10 can improve heart function and reduce cardiovascular risk in adults aged 40 to 75 who have risk factors like high blood pressure, high cholesterol, or diabetes. Participants take either the sup…

This trial tests whether a procedure to remove blood clots from the brain, called endovascular treatment, can improve recovery in people who have had a severe stroke with a very large area of brain damage. Participants receive either the clot-removal procedure plus standard medic…

This trial tests whether a rapid combination of minimally invasive surgery, intensive blood pressure lowering, and a clot-stabilizing drug can improve recovery after a bleeding stroke. Adults with a moderate to large bleed in the brain are randomly assigned to receive this early …

This study tests the long-term safety and effectiveness of an experimental drug called ALXN2220 in adults with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal proteins build up in the heart and impair its function. Participants who completed an earlier …

This trial tests whether a home-based electrical stimulation device can help people recovering from stroke improve their walking. Participants will use the device on leg muscles for 30 minutes, five times a week, for 12 weeks, with remote support via a smartphone app. The study c…

This trial tests whether using ultrasound to mark the correct spot on the back before spinal anesthesia improves success compared with the traditional method of feeling the bones. Sixty women having planned cesarean sections will be randomly assigned to either ultrasound marking …

This study looks at whether a clot-busting drug called prourokinase can improve recovery in people who have an acute ischemic stroke, when given within 4.5 hours of symptoms starting. About 3,000 adults will receive the drug intravenously and be followed for 90 days to see how we…

This phase 3 trial is testing whether Angong Niuhuang, a traditional Chinese medicine, can improve recovery in people who have had a bleeding stroke (intracerebral hemorrhage). About 1,100 adults who are eligible for non-surgical management will receive either the herbal pill or …

This trial compares two common treatments—hypertonic saline and mannitol—to see which is better at reducing dangerously high pressure inside the skull after a severe traumatic brain injury. The study includes 100 adults with severe head injuries and uses a simple ultrasound measu…

This study compares two catheter ablation techniques for treating atrial fibrillation, a common heart rhythm problem. One method uses a single-shot device, while the other uses a focal dual-energy approach. The trial includes 268 adults with symptomatic atrial fibrillation who ar…

This study tests whether using a drug-coated balloon during a procedure to open a blocked artery is better than medication alone for treating plaque erosions, a common cause of heart attacks. About 62 adults who have had a heart attack and have plaque erosion will be randomly ass…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This trial tests whether genistein, a natural compound found in soy, can reduce inflammation and improve blood vessel health in people living with HIV. Even with effective HIV treatment, the body stays inflamed, raising the risk of heart disease and other problems. The study give…

This trial tests whether a traditional Chinese herbal formula, Fuzheng Yangxin, can help people recover better after coronary artery bypass grafting (CABG), a common heart surgery. The study includes 230 patients who have the surgery and show signs of a specific imbalance (qi-yin…

This trial investigates whether using a temporary heart pump (microaxial flow pump) right after opening a blocked artery improves survival in people with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. It also tests whether advanced monitor…

This trial tests whether nicotinamide riboside, a form of vitamin B3, can improve walking ability in people aged 50 and older with peripheral artery disease (PAD). Participants will take either the supplement or a placebo for six months. The main goal is to see if the supplement …

This trial tests a 12-week community program for older stroke survivors who also have high blood pressure or type 2 diabetes. Participants take part in physical activities like exercise and nutrition education, plus cognitive games on an AI-enabled large screen. The goal is to se…

This trial tests whether apixaban, a blood thinner, can reduce the risk of stroke or blood clots in adults on dialysis who also have atrial fibrillation (an irregular heartbeat). Participants are randomly assigned to receive either apixaban or no oral anticoagulant, while continu…

This trial investigates whether a new technique called pulsed field ablation (PFA) can more effectively treat atrial fibrillation, a common heart rhythm problem. The procedure uses short electrical pulses to create precise lesions in the heart tissue, aiming to block faulty signa…

This trial tests whether a communication training program for emergency dispatchers can help them recognize cardiac arrest over the phone and guide callers to start CPR faster. The study involves about 987 adults who experience cardiac arrest outside of a hospital and call the SA…

This trial tests whether a team-based care program, initiated in the emergency department, can help adults with severely elevated blood pressure achieve better control. Participants are randomly assigned to either the team-based program or usual care. The team-based program inclu…

This phase 2 trial tests whether a combined antioxidant therapy—ascorbate, N-acetylcysteine, and deferoxamine—can reduce heart muscle damage when given before and during angioplasty for a first anterior ST-elevation heart attack. Adults eligible for primary PCI will be randomly a…

This trial tests whether augmented reality (AR) can allow a technical expert to support doctors remotely during a heart procedure called catheter ablation for atrial fibrillation. Using a HoloLens headset and a remote connection, the expert may guide the procedure from a differen…

This trial tests whether a drug called recombinant human prourokinase (rhPro-UK) can improve recovery in people who have had a stroke caused by a blocked medium-sized blood vessel in the brain, when given 4.5 to 24 hours after symptoms begin. Participants are selected using brain…

This trial tests whether adding a blood-filtering device, called hemoadsorption, to the heart-lung machine can reduce harmful inflammation in children undergoing complex open-heart surgery. The device is designed to remove inflammatory proteins, known as cytokines, from the blood…

This trial compares two ways of managing high blood pressure: using a cuffless wearable device that tracks blood pressure continuously for 24 hours versus traditional office measurements. About 3,000 adults with high blood pressure will be randomly assigned to one of the two stra…

This trial tests whether specific care strategies used in the intensive care unit after cardiac arrest can improve neurological recovery and survival. Adults who remain comatose after their heartbeat is restored will be cared for using either head elevation or a near-supine posit…

This Phase 3 trial is testing whether a microneedle pad delivering botulinum toxin A can improve symptoms of Raynaud's phenomenon and digital ulcers in people with systemic sclerosis. The study compares the microneedle treatment to a placebo, measuring changes in finger temperatu…

This trial tests whether a non-invasive brain stimulation technique, called transcranial temporal interference stimulation, can improve swallowing in adults who have difficulty swallowing after an ischemic stroke. Participants will receive either active or sham stimulation combin…

This trial tests whether epidural spinal cord stimulation can help people with severe brain injury breathe without a ventilator. Ten patients with stroke or traumatic brain injury who need mechanical ventilation will receive a surgically implanted electrode that delivers electric…

This trial is testing whether preparing a blocked leg artery with a special 'scoring' balloon before using a drug-coated balloon improves outcomes compared to using a standard balloon. The study involves people with severe leg artery disease (critical limb-threatening ischemia) w…

This trial asks whether people with heart failure who take SGLT-2 inhibitors (like dapagliflozin or empagliflozin) should continue the medication right up to cardiac surgery, rather than stopping it three days before as currently recommended. The study will compare outcomes like …

This trial investigates whether combining two behavioral therapies can help people with non-fluent aphasia—a condition where stroke damages the brain's language centers, making speech difficult. The approach uses Melodic Intonation Therapy (MIT), which uses singing-like intonatio…

This trial tests whether icosapent ethyl, a purified form of fish oil, can stabilize high-risk coronary plaques in people with heart disease. Participants have plaques that narrow a major heart artery by 30–70% and show at least one high-risk feature on a CT scan. Half will take …

This trial tests whether aspirin and a non-invasive physical therapy called ischemic conditioning can slow the progression of moyamoya disease, a rare brain vessel disorder that can cause strokes and cognitive decline. The study enrolls adults with moyamoya disease or syndrome wh…

This trial tests whether a newer pacing method, called left bundle branch area pacing, is better than the standard right ventricular pacing for adults with permanent atrial fibrillation and a need for a pacemaker. The goal is to see if the newer technique reduces the risk of deat…

This study looks at whether switching to a higher-dose eye injection called aflibercept 8 mg can allow people with neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DME) to go longer between treatments. It follows adults in Portugal who have already …

This trial tests whether a simple, non-invasive technique called remote ischemic preconditioning (RIPC) can reduce brain damage after an aneurysmal subarachnoid hemorrhage, a severe type of stroke. The procedure involves briefly inflating a blood pressure cuff on the leg to restr…

This trial is testing a new medical device called FRED X, designed to treat brain aneurysms—weak spots in blood vessels that can bulge and potentially rupture. The study will enroll about 15 people with a single untreated aneurysm to see if the device, used with blood-thinning me…

This study tracks the safety and effectiveness of J&J MedTech devices used to remove blood clots in people with acute ischemic stroke. It will follow about 5,000 adults who receive these devices as part of their routine care, measuring how well blood flow is restored and how pati…

This trial investigates whether guanfacine or cromolyn sodium—two drugs already approved for other conditions—can improve physical functioning and reduce symptoms like fatigue, brain fog, and gastrointestinal issues in adults with postural orthostatic tachycardia syndrome (POTS).…

This trial tests whether starting a temporary balloon pump in the aorta before the standard artery-opening procedure (angioplasty) can improve outcomes for people who arrive at the hospital 4 to 12 hours after a major heart attack. Half of the participants will receive the balloo…

This trial tests whether an experimental drug called CS1, taken as a daily pill, can improve blood vessel function in people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes the heart work harder. Participants will receive CS1 o…

This trial tests whether giving praziquantel three times a year, instead of the standard once a year, can improve liver fibrosis (scarring) caused by schistosomiasis in people aged 15-40 in Uganda. Participants with liver fibrosis will be randomly assigned to one of two treatment…

This trial is testing a new device called MRace to repair a leaky mitral valve in people with severe functional mitral regurgitation, a condition where the valve doesn't close properly, causing blood to flow backward. The device is placed through a vein in the leg and guided to t…

This study tests a new device called MRace, designed to repair severe mitral regurgitation—a condition where the heart's mitral valve doesn't close properly, causing blood to leak backward. The device is implanted through a vein in the leg, avoiding open-heart surgery, and is aim…

This trial asks whether starting dialysis early—within 6 hours—in patients with cardiogenic shock and fluid overload can reduce deaths in the hospital compared to waiting until it's clearly needed. It enrolls adults in intensive care with severe heart pump failure and signs of ex…

This study tests a new device called MRace, designed to repair a leaky mitral valve in the heart without open surgery. The device is placed through a vein in the leg and guided to the heart to help the valve close properly. The trial will include up to 15 people with severe mitra…

This trial tests whether repairing a leaky mitral valve early, using a minimally invasive clip procedure, can help people with heart failure and reduced pumping function tolerate and benefit from standard heart failure medications. Participants are randomly assigned to receive th…

This trial tests whether Cerebrolysin, given after a procedure to remove a blood clot from the brain, can reduce tissue damage and improve recovery in people with acute ischemic stroke. The study involves 100 adults aged 18 to 80 who undergo successful clot removal within 6 to 24…

This study tests whether giving creatine monohydrate, a popular sports supplement, twice a day for 12 weeks is safe and practical for children and teenagers recovering from a moderate-to-severe brain injury, including traumatic brain injury or stroke. The trial will enroll 46 par…

This trial is testing whether a new heart valve device, called Myval, can safely and effectively treat people with severe aortic regurgitation—a condition where the heart's aortic valve doesn't close properly, causing blood to leak backward. The study involves about 164 adults wh…

This trial tests whether faricimab, an eye injection, can improve vision and reduce swelling in South Asian patients with diabetic macular edema (DMO), a complication of diabetes that can lead to blindness. Previous studies mostly included Caucasian or East Asian participants, le…

This trial tests whether a smartphone app that uses light to measure heart rhythm can reliably detect when atrial fibrillation (AF) spontaneously returns to a normal heartbeat. About 200 adults with AF scheduled for an electrical cardioversion will either receive standard care or…

This trial tests whether rimegepant, a newer migraine medication, works as well as flunarizine, an older preventive, for reducing days with moderate-to-severe dizziness in people with vestibular migraine. About 400 adults aged 18 to 75 will take one of the two drugs daily for 12 …

This trial tests whether ezetimibe, a common cholesterol-lowering medication, can reduce the return of irregular heartbeats in people with persistent atrial fibrillation who undergo catheter ablation. Half of the 120 participants will take ezetimibe daily for six months after the…

This phase 2 trial is testing an investigational drug called QLS4131 in people newly diagnosed with AL amyloidosis, a condition where abnormal proteins build up in organs and cause damage. QLS4131 is a trispecific antibody designed to target and eliminate the plasma cells produci…

Researchers in Qinghai Province, China, are testing whether artificial intelligence can help primary care doctors spot congenital heart disease during school-based screening. Schools are randomly assigned to either standard listening with a stethoscope or listening plus AI analys…

This study tests advanced CT scans to find dangerous blockages in heart arteries without needing to insert a tube into the heart. About 142 adults with moderate blockages will get two types of CT scans, and results will be compared to the standard invasive test. The goal is to se…

Researchers are testing whether a smartphone app called Stethophone can help primary care doctors find moderate or severe aortic stenosis in adults aged 70 and older. The app turns a phone into a digital stethoscope and analyzes heart sounds for murmurs that may signal the condit…

Many people with diabetes skip regular eye exams, even though early treatment can prevent vision loss. This pilot study tests whether offering retinal photography during routine occupational health visits makes screening easier to access. Workers with diabetes attend one visit wh…

Researchers at Corewell Health West are testing whether medical assistants can use a handheld ultrasound device to estimate heart pumping function in people with new heart symptoms. The trial enrolls up to 100 adults at rural outpatient clinics who have not had a recent echocardi…

Researchers are studying whether the total time from heart attack symptom onset to balloon inflation during angioplasty helps predict contrast-induced nephropathy, a kidney complication that can occur after the procedure. The trial enrolls 400 adults with ST-segment elevation myo…

Researchers are testing a soft, wearable ultrasound patch that sticks to the chest and continuously images the heart in adults and children with severe heart conditions in intensive care. The study compares heart function measurements from the patch with results from standard bed…

Researchers at Massachusetts General Hospital are studying whether molecular imaging and detailed biological profiling can predict how quickly aortic stenosis gets worse. The trial enrolls 100 adults with mild to moderate calcific aortic stenosis. Participants receive a baseline …

Researchers at Assiut University Hospitals are studying how well fetal heart scans before birth match the heart diagnoses babies receive after delivery. The study includes pregnant women referred for fetal echocardiography and newborns with confirmed critical congenital heart dis…

Researchers are testing whether a non-invasive device that reads the heart's magnetic signals can help emergency department doctors tell high-risk from low-risk chest pain. The study enrolls adults 22 and older who arrive with symptoms suggesting a possible heart attack and who f…

Acute kidney injury is a common complication after coronary artery bypass grafting. This observational study examines whether two measurements from kidney Doppler ultrasound, the renal augmented velocity index and the renal resistive index, can predict which patients will develop…

Researchers at Assiut University are studying whether two ultrasound measures of fetal heart function and blood flow can predict poor outcomes in pregnancies complicated by diabetes or preeclampsia. The study enrolls 69 pregnant women, including those with gestational diabetes, p…

Researchers are testing the Circle Safe System, a device that stimulates the phrenic nerve and records the diaphragm's electrical response during pulmonary vein ablation for atrial fibrillation. The study enrolls up to 50 adults scheduled for this procedure. All participants rece…

Researchers are studying whether two bedside ultrasound techniques can help emergency doctors identify traumatic brain injury patients at risk of getting worse within 24 hours. The study enrolls 60 adults with acute traumatic brain injury and a low Glasgow Coma Scale score who ar…

Researchers are testing a noninvasive MRI technique that uses inhaled hyperpolarized xenon gas to measure lung function in adults with interstitial lung disease, pulmonary hypertension, and systemic sclerosis. The study includes about 51 participants, including healthy volunteers…

Peripheral artery disease narrows the vessels that carry blood to the legs, and surgery to restore flow does not always go well. Researchers at Fudan University are studying whether CT perfusion, a scan that measures blood flow in tiny vessels, can help predict which patients wil…

Researchers are checking whether an Indonesian version of the Oxford Cognitive Screen-Plus accurately measures thinking skills in people who have had a stroke. The study enrolls 75 adults who can read and speak Indonesian and are in the subacute or chronic phase after stroke. Par…

Carotid endarterectomy removes plaque from the neck artery, and surgeons clamp the artery briefly during the operation. In awake patients, doctors check hand strength and speech to decide if a shunt is needed. This study tests whether a forehead sensor that measures brain oxygen …

Researchers are testing an experimental PET imaging tracer called 18F-S2P to see how well it detects inflamed plaques in people with large-artery atherosclerosis. About 200 adults aged 40 to 80 with suspected atherosclerosis receive an intravenous dose of the tracer and then unde…

Researchers are testing whether continuous heart monitoring can lower unplanned hospital visits in adults with heart failure who have never shown signs of atrial fibrillation. One group receives a small monitor implanted under the chest skin, another uses a handheld device for we…

Researchers are testing whether adding organ Doppler ultrasound to standard echocardiography helps doctors better manage a common heart vessel problem in preterm infants. The trial enrolls 88 premature babies born before 34 weeks or weighing under 1800 grams. Half receive standar…

Researchers at Assiut University are investigating whether the severity of erectile dysfunction mirrors the severity of coronary artery disease in men aged 18 to 50. The study enrolls 120 men who are undergoing coronary angiography for suspected or confirmed heart conditions. Par…

Researchers at Mayo Hospital Lahore are studying whether the Surgical Apgar Score can identify patients who need direct admission to the intensive care unit after emergency abdominal surgery. The score uses three factors recorded during surgery: estimated blood loss, lowest mean …

This pilot study will test whether an AI-assisted ultrasound device can help emergency doctors quickly detect heart failure in patients with symptoms. About 84 adults visiting the ER with signs of heart failure will be enrolled. The goal is to see if this approach is practical an…

This study will test a new type of CT scanner that uses silicon-based detectors to take detailed pictures of the heart. The goal is to see if it can provide clearer images of coronary arteries while using less radiation and contrast dye than current scanners. About 1,000 adults r…

Researchers are testing whether an open-source artificial intelligence model can measure coronary artery calcium on routine chest CT scans that were not originally taken for heart imaging. The study uses existing scans from about 1,950 people at a German hospital, including patie…

Researchers are testing a new device called KV-PREDICT that sits on the chest, over clothing, and records heart signals for about 10 seconds. The study includes 120 adults with heart failure across different severity levels. The goal is to see if the device can capture clear, rep…

This study tests whether a special PET-CT scan using a drug called evuzamitide can detect signs of cardiac amyloidosis in people whose standard heart scans were unclear but who have high levels of a blood marker called TAD1. About 25 adults with heart failure or a genetic risk fo…

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This trial tests whether a bedside ultrasound of the eye can reliably detect raised pressure inside the skull, a condition that can damage the brain if not treated quickly. Researchers will measure the optic nerve sheath diameter in adults suspected of having high brain pressure …

This trial compares two imaging strategies—CT with CT angiography versus MRI with MR angiography—as the first test for people with suspected severe ischemic stroke. The goal is to see which approach is more cost-effective while still leading to good patient outcomes. Six hundred …

This study tests whether using an AI program to screen for diabetic eye disease during regular primary care visits can get more people to follow up with an eye specialist. It will include 4,000 adults with diabetes who have Medicaid and haven't had an eye exam in the past year. T…

This study tests whether a high-powered 7T MRI can measure sodium levels in the brain tissue around a bleeding stroke, and whether a drop in sodium predicts worse swelling and disability. Researchers will also use an AI algorithm to create similar sodium maps from standard 3T MRI…

Researchers at Assiut University are testing whether a new ultrasound measurement, the Amniotic-Umbilical-to-Cerebral Ratio (AUCR), can predict complications in newborns of women with hypertensive disorders of pregnancy. They will compare AUCR with the traditional Cerebroplacenta…

Researchers at Mayo Clinic are testing whether people who have a type 2 heart attack, without major blockages in the large heart arteries, are more likely to have disease in the tiny blood vessels of the heart. The study uses a special X-ray procedure called coronary reactivity t…

This trial tests whether a Huawei smartwatch can measure blood pressure accurately with fewer readings than the standard 24-hour monitor, which inflates a cuff every 15 to 30 minutes and often disrupts sleep. About 500 adults in Malaysia will participate, with a subgroup of 50 un…

This study tests whether a Huawei smartwatch can accurately identify adults at risk for hypertension (high blood pressure) in everyday settings. About 500 adults in Malaysia will wear the smartwatch, which uses light sensors to estimate blood pressure. A subgroup of about 50 peop…

This study looks at whether taking a tiny tissue sample from the heart during a pacemaker or defibrillator implant can help diagnose transthyretin cardiac amyloidosis (ATTR-CM), a condition where abnormal proteins build up in the heart. The trial enrolls people aged 65 and older …

This study tests whether a portable, radiation-free ultrasound performed at the bedside can accurately detect brain injuries in children, compared to the standard head CT scan. Researchers will enroll 220 children aged 2-17 who are already scheduled for a head CT due to suspected…

This trial tests whether an AI-guided handheld ultrasound, used during routine primary care or geriatrics visits, can detect serious heart valve disease and weak heart muscle in adults aged 65 to 85 who have no known heart problems. Half of the participants will receive this quic…

This study tests whether a computer algorithm can analyze standard EEG recordings from full-term newborns who experienced oxygen deprivation at birth to tell apart mild brain injury from moderate or severe forms. The algorithm's readings are compared against expert review of the …

This trial tests whether Epidiolex, a prescription CBD medication, can delay or prevent the first seizure in infants with Sturge-Weber syndrome, a rare condition that often leads to seizures and developmental challenges. The study enrolls babies aged 1 to 18 months who have brain…

Researchers are testing a community-led prevention program called Qungasvik-Healthy Hearts in three rural Alaska Native communities. The program adapts traditional Yup'ik practices such as hunting, gathering, and fishing to see whether they can reduce risk factors for heart and c…

Researchers are testing whether a digital program that combines a smart bracelet and a mobile app can help people who have had an ischemic stroke avoid another one. The study enrolls adults who recently had a stroke and also have high blood pressure and diabetes. Half receive usu…

Researchers are testing whether mild electrical stimulation of a nerve in the ear can prevent atrial fibrillation, a common irregular heartbeat, after off-pump coronary artery bypass surgery. Adults scheduled for this heart surgery receive either the stimulation plus standard car…

Spinal anesthesia for cesarean delivery often causes a sudden drop in blood pressure. Researchers are testing different infusion rates of phenylephrine, a drug that narrows blood vessels, to find the dose that prevents this drop in most women. The trial enrolls 200 women with ful…

Chronic pain after heart surgery through a breastbone incision affects many patients and can last for years. Researchers are testing whether an ultrasound-guided nerve block, given after anaesthesia but before the first cut, can reduce the chance of chronic pain three months late…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

This trial tests whether ticagrelor, an antiplatelet drug, can prevent stroke and delayed brain ischemia in people who have had a low-grade aneurysmal subarachnoid hemorrhage. Participants receive either ticagrelor or a placebo for 14 days, starting just before endovascular treat…

This study tests whether a numbing injection around a nerve cluster in the neck, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (irregular heartbeat) in the first week after surgery. About 450 adults scheduled for bypass will …

This trial tests whether a school-based program called Operation ToneUp can improve fitness, nutrition knowledge, and blood pressure in children in grades 3 through 6. Students in participating schools will complete two 20-minute web-based sessions each week during class time, fo…

This trial tests whether a structured oral hydration plan—drinking at least 1,500 mL of fluid within 12 hours around the procedure—can reduce the risk of contrast-induced acute kidney injury (CI-AKI) in patients with ST-elevation myocardial infarction (STEMI) undergoing primary P…

This trial tests whether giving children aged 5 to 8 a twice-daily penicillin pill can prevent rheumatic heart disease, a serious condition that can damage heart valves. Researchers will compare children who take the antibiotic with those who do not, following them for three year…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This trial tests a program called Tools for Arctic Health Promotion (TAHP) in rural Alaska Native communities. The goal is to see if community-led activities can reduce stress, anxiety, and depression while increasing life satisfaction and cultural connection. About 360 youth and…

This trial tests whether an AI-driven health management program can reduce the chance of a first ischemic stroke in adults at high risk. Participants in Beijing communities will be randomly assigned to either AI-supported care or usual community health services. The AI program us…

This trial tests whether high-intensity cholesterol-lowering therapy prevents strokes and heart problems better than moderate therapy in adults with narrowing of brain arteries but no symptoms yet. Participants are randomly assigned to one of two treatment strengths and followed …

This phase 3 trial will test whether a low dose of the blood thinner rivaroxaban plus aspirin can prevent recurrent strokes better than the standard clopidogrel plus aspirin in people with narrowed brain arteries. About 1,172 participants who recently had a stroke or high-risk TI…

This trial compares two drugs, dexamethasone and ondansetron, given before spinal anesthesia for cesarean delivery in women with preeclampsia. Spinal anesthesia often causes a sudden drop in blood pressure, which can reduce blood flow to the placenta and vital organs. Researchers…

This phase 3 trial tests whether orforglipron, a daily oral medication, can help overweight adults reduce their risk of developing obesity-related complications such as type 2 diabetes, high blood pressure, and high cholesterol, as well as progression to class 1 obesity. Particip…

This pilot study tests a lifestyle intervention called BASIC-S, which uses coaching, text messages, and video check-ins to help people improve blood pressure, activity, sleep, social connection, nutrition, and support. The goal is to see if this approach is feasible and acceptabl…

This trial tests whether pairing women who had high blood pressure during or after pregnancy with a trained community health worker for six months can lower their blood pressure compared to usual care. Participants are randomly assigned to receive either standard care or standard…

Researchers compare two sedatives, remimazolam and propofol, for patients with heart disease who need a transesophageal echocardiogram (TEE), a procedure that uses a tube in the esophagus to take pictures of the heart. Adults scheduled for an elective TEE receive one of the two d…

People on hemodialysis must closely manage fluid, diet, and their vascular access between sessions, and sticking to these routines is hard. Researchers at the University of Rome Tor Vergata built DialysisBot, an AI chatbot that answers patient questions using only a hospital-appr…

Children scheduled for angiography often feel anxious, which can affect their heart rate, blood pressure and cooperation during the procedure. This trial tests whether a short virtual reality guided breathing exercise, delivered through a headset showing calming scenery, can redu…

Researchers are testing whether enhanced external counterpulsation (EECP), a noninvasive treatment that uses inflatable cuffs on the legs and buttocks timed to the heartbeat, can improve blood pressure and erectile function in men aged 60 to 75 who have both hypertension and erec…

Researchers test whether optokinetic stimulation without a reading task improves reading speed in adults with hemianopic alexia after stroke. Participants receive 4 weeks of stimulation without a reading task and 4 weeks with a reading task, in random order. The study compares re…

Stroke survivors often walk more slowly and struggle to produce the movements needed for efficient walking. This study tests whether small wearable devices that vibrate during walking can help people with chronic stroke change specific walking movements linked to speed, propulsio…

This study tests whether giving high-flow oxygen through special nasal prongs during a less-invasive heart valve replacement (TAVR) can prevent low oxygen levels and breathing complications. About 452 older adults undergoing TAVR under sedation will be randomly assigned to receiv…

Researchers are testing whether older adults with high blood pressure who report insomnia can improve their sleep by pressing six acupoints on themselves each night for 28 days. The trial compares this self-acupressure routine with sleep hygiene training in 94 participants aged 6…

Researchers test whether adding inspiratory muscle training to a walking program helps adults on hemodialysis who also have atrial fibrillation. Participants do breathing exercises through a mouthpiece and walk for six minutes, while the study tracks heart rate, blood pressure, k…

Aortic arch surgery temporarily cuts blood flow to the brain, which can leave patients with lasting thinking and memory problems. Researchers at Seoul National University Hospital are testing whether anesthesia with remimazolam, rather than propofol, lowers the chance of that cog…

Researchers are testing whether nurse-led lessons delivered through virtual reality or a tablet help people with coronary artery disease understand their heart risks and take their antiplatelet medicines as prescribed. The trial enrolls 54 adults aged 18 to 65 who have coronary a…

Some brain tumors, including meningiomas, hemangioblastomas, and certain metastases, have a rich blood supply that makes surgical removal difficult and risky. This study tests whether blocking the tumor's feeding blood vessels with a catheter procedure before surgery reduces blee…

This study tests whether regular breathing exercises can improve symptoms of Postural Tachycardia Syndrome (POTS), a condition that causes dizziness and rapid heartbeat when standing. Twelve adults with POTS will practice breathing exercises daily for four weeks while researchers…

This trial tests whether an experimental oral drug called BR005-036C can quickly relieve migraine attacks in adults. Researchers will compare two doses of the drug against a placebo in about 2,079 people who have migraines with or without aura. The main goals are to see if the dr…

Researchers are testing a new device called the Solutio™ catheter to see if it can safely deliver numbing medicine (tumescent anesthesia) from inside the great saphenous vein before endothermal ablation, a common treatment for varicose veins. The trial enrolls 30 adults with veno…

Researchers at Emory University are testing whether a fully provided, unrefined, polyphenol-rich plant-based diet can improve blood vessel function in adults with coronary microvascular dysfunction, a condition where the heart's small vessels cannot deliver enough blood despite c…

Researchers are testing whether a structured prenatal education program based on the Roy Adaptation Model can reduce stress and improve quality of life for pregnant women with hypertensive disorders. The study enrolls 54 pregnant women between 20 and 32 weeks of gestation who hav…

Researchers compare two pulsed-field ablation catheters, the Sphere-9 lattice-tip and the FARAPULSE pentaspline, in people with symptomatic persistent atrial fibrillation. All participants undergo pulmonary vein isolation, the only allowed ablation lesion set, and receive an impl…

This study tests whether applying mild electrical stimulation to specific acupoints on the wrist before anesthesia can prevent low blood pressure in older adults undergoing surgery. Researchers will compare high-frequency versus low-frequency stimulation in 84 participants aged 6…

Researchers are testing whether adding diaphragmatic breathing training to standard physiotherapy helps people with chronic stroke improve trunk control and postural stability. Forty adults who had a stroke at least six months earlier will be randomly assigned to either breathing…

This study tests whether using a lower-sodium dialysis fluid can improve blood pressure and blood vessel function in people with kidney failure on hemodialysis. Twenty-five participants will each receive both a low-sodium and a standard-sodium dialysis for three weeks, in random …

Emergency medical services teams use defibrillator pads to shock the heart during out-of-hospital cardiac arrest. The VECTORS trial compares two standard pad placements: one with pads on the front and back of the chest, and one with pads on the front and side. Researchers will tr…

This study tests whether a structured 5-week cardiac rehabilitation program can improve exercise ability and quality of life in 40 adults with cardiac amyloidosis. Participants will undergo supervised aerobic and strength training five days a week, with tests before and after the…

Researchers are studying whether donor hearts can be safely stored and transported at 10°C using a portable cooler called the X°Port Heart Preservation System. The trial enrolls up to 25 adults who are listed for heart transplantation. Participants receive a standard heart transp…

Researchers are testing whether a rehabilitation program that combines mental tasks with balance exercises helps stroke survivors who have hemispatial neglect, a condition where the brain ignores one side of the body or space. Participants are randomly assigned to receive either …

Infantile hemangioma is a common birthmark that can grow quickly in a baby's first months. Researchers are testing a 5% simvastatin ointment applied directly to the skin of babies aged 3 to 6 months with newly diagnosed superficial hemangiomas. The study checks whether the ointme…

This study looks at how a cannabis-based drug (Dronabinol) affects blood pressure and heart function. Researchers will measure blood pressure, heart rate, and nerve activity in 50 healthy adults aged 21-40 who use cannabis occasionally. The goal is to see if cannabis can help man…

Researchers test whether infusing lidocaine into the middle meningeal artery reduces headache severity in adults who have had a bleeding brain aneurysm. Participants receive either lidocaine or a saline placebo during their endovascular aneurysm repair. The trial measures headach…

Researchers are testing an oral drug called elismetrep (K-304) to see if it can quickly relieve moderate or severe migraine attacks. The Phase III trial enrolls about 1,500 adults aged 18 to 75 who have had migraines for more than a year. Participants receive either elismetrep or…

Researchers are testing whether giving naloxone soon after resuscitation starts can help people whose hearts stop outside the hospital after an opioid overdose. The trial enrolls adults in out-of-hospital cardiac arrest who are at risk of opioid involvement and who have received …

This study looks at whether adding a non-invasive brain stimulation technique called rTMS to standard physical therapy can help people with chronic stroke-related weakness improve their movement, balance, and quality of life. Twenty adults who had a stroke at least six months ago…

Researchers are testing a cardiac pulsed field ablation system that uses a spherical catheter to treat symptomatic, recurrent paroxysmal atrial fibrillation that has not responded to drugs. The trial enrolls 284 adults and randomly assigns them to either the investigational pulse…

Hemorrhoidectomy often causes severe pain, and doctors use pudendal nerve blocks to help. Researchers are testing whether a block placed higher up near the ischial spine works better than one placed lower near the perineum. Adults having elective hemorrhoid surgery receive one of…

Adults with congenital heart disease often develop supraventricular tachycardia, a fast or irregular heartbeat that can be hard to treat because of unusual heart anatomy or prior surgeries. This study follows 40 adults who have a cardiac ablation procedure using the MAGiC ablatio…

After a stroke, many people need rehabilitation to regain movement, balance, and independence, but repetitive exercises can be hard to keep up. This small Swedish study tests a mixed-reality system called RehAtt XR, which uses special glasses to project digital holograms into the…

Researchers are testing a new defibrillator lead called the Medtronic OmniaSecure Model 3930M in people who need a defibrillator and also have moderate or worse tricuspid valve regurgitation. The lead is placed through the middle cardiac vein, a different route than usual, with t…

Researchers are testing a device called the FlowMod System in people hospitalized with acute decompensated heart failure. The device partially blocks blood flow in the large veins that return blood to the heart, which may reduce the heart's workload. The trial will check whether …

Researchers are testing whether squeezing a stress ball during femoral arterial sheath removal after coronary angiography can reduce pain and anxiety and improve patient satisfaction. The trial enrolls 34 adults who had a stent or balloon angioplasty through the femoral artery. H…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This study tests if using a cotton-tipped applicator to hold the eyelid open during eye injections is less painful and faster than the standard metal speculum. About 120 adults with certain eye conditions will take part. The goal is to improve comfort and satisfaction without com…

This trial tests a program called HEROIC, designed to support people caring for someone with advanced heart failure. Caregivers receive five one-on-one video sessions with a nurse over 10 weeks, focusing on mental health, self-care, and connecting with community and palliative re…

This trial tests whether an 8-week lifestyle program can reduce the burden of chronic migraine, a condition marked by headaches on at least 15 days per month. Adults aged 18 to 55 with chronic migraine will be randomly assigned to either the lifestyle program or a wait-list contr…

This pilot trial tests whether a 12-week home-based exercise program, called ASK, is feasible and beneficial for postpartum women who had high blood pressure during pregnancy. The program combines aerobic exercise, strength training, and Kegel exercises, guided by a mobile app an…

This trial tests a 12-week spiritual nursing program called SHS-Zikir, which combines guided spiritual sessions with Islamic dhikr practices, for Muslim adults with heart failure. The program aims to strengthen a person's connection with Allah, self, others, and the environment t…

This trial tests whether a 6-week prehabilitation program called Ready for Recovery can help adults prepare for aortic aneurysm repair surgery. The program includes education, health behavior support, psychological symptom reduction, and social support, with weekly phone sessions…

This trial tests whether guided imagery, a relaxation technique using audio recordings, can reduce anxiety and improve sleep and comfort in adults with acute coronary syndrome, such as a heart attack, who are in a cardiac intensive care unit. Participants will be randomly assigne…

Researchers at Yale University are testing whether cognitive behavioral therapy for migraine (CBTm) can improve quality of life for veterans with episodic migraine. The study compares CBTm, a six-session behavioral program, to a digital migraine education intervention. Participan…

This study tests two ways to deliver a group training program for caregivers of children with autism in low-resource areas. The program aims to reduce caregiver stress and improve the child's communication and behavior. About 320 caregivers of children aged 2 to 8 will take part.…

This pilot study tests whether adding regular sauna sessions to usual care can help lower blood pressure in people with primary aldosteronism, a condition that causes high blood pressure. Ten adults will attend three 30-minute sauna sessions per week for two weeks while wearing a…

This trial tests whether a long-acting local anesthetic, liposomal bupivacaine, provides better pain relief than the standard ropivacaine when injected around the surgical site after open hemorrhoidectomy. Adults aged 18 to 60 with grade III-IV hemorrhoids will receive one of the…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This trial tests a program that gives heart failure doctors, nurses, and social workers a structured guide for having serious conversations with older patients and their care partners. The goal is to help care teams understand what patients hope for, worry about, and know about t…

This trial tests whether listening to a personalized music playlist during coronary interventional procedures can reduce anxiety and pain. About 208 adults with acute coronary syndrome will be randomly assigned to either standard care or standard care plus music through wireless …

This study is testing whether a computer-based brain training program called RehaCom Online is acceptable and feasible for young stroke survivors (aged 18-65) who are working toward returning to work. Participants will use the program for at least 30 minutes, twice a week, for fi…

This trial tests whether wearing a light-blocking eye mask at night can improve sleep quality and reduce delirium in patients recovering from coronary artery bypass graft (CABG) surgery. About 100 adults scheduled for elective CABG will wear the mask during nighttime sleep, and t…

This trial tests whether applying a numbing medicine (lidocaine) to a nerve cluster inside the nose can quickly relieve migraine headaches, facial pain, and neck pain. Adults who have frequent headaches and facial pressure will receive either lidocaine or a saltwater placebo duri…

This trial tests whether placing a small catheter near the breastbone to deliver local anesthetic can reduce pain after coronary artery bypass surgery. Half of the participants will receive this catheter-based pain relief, while the other half gets standard care. Researchers will…

This pilot trial tests whether NeuroEyeCoach, a computer-based eye movement training program, can help stroke survivors who have lost part of their visual field. Sixty participants will be randomly assigned to receive either the training plus usual care or usual care alone. The s…

This study will take standard heart CT scans from 1000 adults with structural heart disease and use a super-computer to create ultra-high-resolution images. The goal is to see if these enhanced images show more detail than the originals. No new treatments are being tested; it's a…

This study investigates clonal hematopoiesis, an age-related condition where blood stem cells acquire mutations, and how it triggers inflammation linked to heart disease. Researchers will compare immune cells from healthy people, those with high-risk mutations, and patients with …

This study looks at 22 children with congenital heart disease who are getting a blood thinner called heparin. Doctors want to see if taking blood from a central line (a special IV) gives the same results as taking blood from an artery. They will compare three different ways of dr…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

Researchers want to know whether migraine leaves a measurable biological trace in the body. They will collect blood, saliva and tear fluid from 60 adults with episodic migraine, both during an attack and between attacks, and compare the samples with those from people who do not g…

This pilot study will test a new method to see how two pain medicines, naproxen and pregabalin, work in healthy adults. Up to 25 participants will receive each medicine and a placebo in random order. They will undergo several short, controlled pain tests, like a cold water hand b…

Researchers at University Health Network in Toronto are reviewing the records of 150 adults who had septal myectomy for hypertrophic obstructive cardiomyopathy. They compare intraoperative echocardiograms with predischarge echocardiograms to see how often moderate or worse mitral…

This study is creating a large collection of blood samples and medical information from 1000 adults with or suspected of having pulmonary hypertension (PH). Researchers hope this resource will help them find new ways to diagnose and treat PH. Participants will provide a blood sam…

This study tests whether having a neurologist consult via video during ambulance transport helps decide the best hospital for suspected stroke patients. About 484 adults with stroke symptoms will be randomly assigned to standard care or standard care plus a telemedicine consultat…

Researchers at Changhai Hospital are setting up a nationwide system to monitor how well devices and procedures for cerebrovascular conditions perform after they reach the market. The study plans to enroll about 2,000 adults with acute ischemic stroke, narrowed brain or neck arter…

Researchers want to know whether CGRP, a protein involved in migraine, also affects the vestibulo-ocular reflex, the automatic eye movement that keeps vision steady when the head turns. The trial gives 80 people at the University Hospital Zurich either a single dose of atogepant,…

This study will measure normal blood clotting values in 240 children under 18 who are having surgery or a procedure with anesthesia. The goal is to establish reference ranges for the Quantra system, a device that checks how well blood clots. This information will help doctors bet…

Researchers at Assiut University Hospitals are studying how often adults with multiple sclerosis also get primary headaches such as migraine and tension-type headache. About 100 patients will complete a single visit that includes a neurological exam, headache history, disability …

Researchers want to understand why most IVF embryo transfers fail to implant and what goes wrong in pregnancies complicated by preeclampsia. They will collect small tissue samples from the womb lining of up to 500 women aged 18 to 50 who are already scheduled for a diagnostic hys…

People with rheumatic heart disease and atrial fibrillation take warfarin to prevent strokes, but the drug only works safely when blood clotting stays in a narrow target range. Researchers at Assiut University are studying about 90 Egyptian adults on warfarin for at least six mon…

This study will test if an AI chatbot can give helpful nutrition advice to pregnant women. About 100 women will either use the chatbot or get standard care. The goal is to see if the chatbot is easy to use and if it helps improve diet and knowledge about conditions like gestation…

Researchers at Assiut University Hospitals are following 250 adults with chronic heart failure and reduced ejection fraction who are on or starting guideline-directed medical therapy. Over three months, the team measures changes in heart pumping function, kidney filtration, quali…

Anti-VEGF injections treat conditions like diabetic macular edema, age-related macular degeneration, and retinal vein occlusion by adding fluid inside the eye, which can briefly raise eye pressure. This observational study at Assiut University follows 50 adults receiving these ro…

Researchers want to know whether caffeine consumption is linked to irregular heartbeats and daily physical activity in adults with heart failure, reduced left ventricular ejection fraction, and an implantable cardioverter-defibrillator (ICD). About 170 participants fill out a one…

Researchers at Assiut University Children Hospital are studying how often children who come to the emergency department have an abnormal heart rhythm. The study includes children aged 1 month to 18 years who arrive with symptoms such as palpitations, chest pain, fainting, or trou…

This study will track 320 people in Hong Kong who have a heart attack complicated by cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will collect data on standard treatments, including the use of a heart pump called Impella, to…

This study will observe 3,000 adults in China with a type of heart failure called HFpEF who are starting the drug Jardiance. Researchers will track how many patients are hospitalized for heart failure or die from heart-related causes over time. The goal is to see how effective an…

Researchers at Lokman Hekim University are studying how migraine affects daily life and which factors track with worse disability. About 100 adults diagnosed with primary migraine complete questionnaires on headache features, sleep quality, fatigue, neck pain, and lifestyle, plus…

Researchers at Assiut University Children Hospital are following 60 newborns diagnosed with pulmonary hypertension, a condition where high blood pressure in the lungs makes breathing difficult. The study collects clinical, laboratory, and heart ultrasound data to see which early …

This study explores whether artificial intelligence can help perform high-field whole-body MRI scans faster while keeping image quality high. Researchers will compare standard MRI sequences with AI-accelerated versions in 600 adults undergoing screening for prostate, lung, or vas…

This study will collect real-world information on the VERAFEYE system, a device that creates 3D images of the heart during procedures to treat atrial fibrillation (an irregular heartbeat) and to close the left atrial appendage (a small pouch in the heart). About 50 adults will ta…

Cardiac arrest survival in hospitals stays low, and staff on regular wards rarely face these emergencies. Researchers are studying a simulation-based self-training program that lets nurses, doctors, and assistants practice CPR without leaving their department. The study looks at …

This observational study looks at adults aged 18 to 85 with neurological conditions like stroke, Parkinson's disease, or spinal cord injury who use robotic or virtual reality tools in their rehabilitation. Researchers want to see if hope and the quality of the patient-provider re…

Doctors use anti-VEGF injections to treat retinal diseases such as age-related macular degeneration and diabetic macular edema, and patients often need these shots for years. During each injection, a small tool holds the eyelids open, stretching the upper lid. Researchers want to…

Researchers are studying tiny particles called extracellular vesicles that fat tissue around the heart releases, to understand how this fat may contribute to heart problems in people with obesity. The study enrolls 100 adults and children scheduled for open-heart surgery. During …

Researchers at Chulalongkorn University are running an online survey of about 500 transgender adults in Thailand to learn how common headaches and migraines are in this group. Participants answer questions about their headache symptoms, disability, and use of gender-affirming hor…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

Heparin-induced thrombocytopenia (HIT) is a rare immune reaction that makes heparin dangerous, yet heart bypass surgery normally depends on heparin to keep the machine from clotting. Doctors at 11 French cardiac surgery centers are reviewing past cases where patients with confirm…

Researchers at Assiut University Hospital survey adults with advanced chronic kidney disease about arteriovenous fistula creation, the surgically connected vein and artery used for hemodialysis. The study includes pre-dialysis patients and people already on maintenance hemodialys…

Researchers are running a national registry of hospitalized patients aged 60 and older who have moderate or severe heart valve disease. The study records the type of valve problem, symptoms, other conditions, treatments received, and complications. By comparing this group with pa…

This study is testing whether a deep-learning computer model can predict, from a CT scan taken before surgery, which patients will develop a type II endoleak and aneurysm enlargement after endovascular aneurysm repair (EVAR). The model is being developed using data from multiple …

This study aims to create a version of the Mini-Mental State Examination (MMSE) that works better for people in Reunion Island. The current French version has questions that don't fit local culture. Researchers will test 400 people aged 60-89, both healthy and those with Alzheime…

Researchers are studying whether the Evolut FX Plus replacement heart valve allows doctors to reach the coronary arteries after a TAVI procedure. The trial enrolls about 122 people aged 65 and older with severe aortic stenosis. Right after the valve is implanted, doctors try to t…

This pilot study is testing whether wearable patch monitors can help detect heart problems early in adults undergoing treatment for breast cancer, blood cancers, or multiple myeloma. Participants will wear two patches—one that tracks heart rhythm continuously and another that rec…

This study tests whether artificial intelligence software can predict if atrial fibrillation will return within a year after a standard ablation procedure. Researchers will use the Volta AF-Xplorer II software to map abnormal electrical areas in the hearts of 125 people with pers…

This early-stage trial is asking whether two medications—one for blood pressure and one for cholesterol—can be safely taken together without affecting how each works. Healthy adult volunteers will receive each drug alone and then both together, so researchers can compare drug lev…

This study looks at people aged 65 and older who have signs of brain blood vessel disease on a past scan but no history of stroke, dementia, or other major brain conditions. Researchers will collect information on daily function, thinking skills, speech, and any new vascular even…

This study looks at how blood test results change after delivery in people with severe preeclampsia. Participants are randomly assigned to receive magnesium for either 12 or 24 hours after birth. The goal is to see if a shorter treatment is safe and effective, and to understand h…

This pilot study tests a web-based decision aid for Black and White patients with atrial fibrillation who need to choose whether to take blood thinners to prevent strokes. The tool explains risks and benefits and asks about personal preferences. The study will check if the tool i…

Pulmonary hypertension often goes undiagnosed for a long time because early symptoms are vague. Researchers at Assiut University Heart Hospital are studying whether a longer delay before diagnosis is linked to more advanced disease when patients first present. The study will revi…

Researchers are observing patients in China who have both a tumor in the sellar region of the brain and an unruptured intracranial aneurysm. The study compares three approaches: removing the tumor before treating the aneurysm, treating the aneurysm before removing the tumor, or r…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study tests whether sending an electronic letter to people with heart disease and high cholesterol encourages them to get their cholesterol checked. Researchers will compare those who receive the letter to those who don't, using national health records to track results. The …

This study looks at whether mindfulness-based stress reduction can help Black teenage girls who have been involved with the justice system and their parents or caregivers. About 90 participants will report on stress, PTSD symptoms, and other outcomes before and after the program.…

This study looks at older adults over 65 who are hospitalized after a stroke in a specialized geriatric neurovascular unit in France. Researchers will collect detailed health data, including age, other medical conditions, stroke type, and complications, to describe this populatio…

This study looks at whether a one-week stay at sea level helps people with pulmonary arterial hypertension (PAH) who live permanently above 2600 meters. Researchers will measure lung function, blood oxygen, and sleep quality before, during, and after the descent and re-ascent. Th…

Researchers are testing whether a one-week stay at sea level improves walking ability and blood oxygen in people with pulmonary arterial hypertension who live permanently above 2600 meters. The study compares these patients with healthy controls from the same altitude, measuring …

This study will use heart scans and blood tests to check for early signs of heart disease in 650 adult survivors of childhood cancer. The goal is to better understand who is at highest risk due to past cancer treatments like radiation or chemotherapy. Results will be compared to …

This observational study will use advanced imaging techniques to measure changes in the retina and choroid (the layer beneath the retina) in people with eye diseases and healthy volunteers. Over 5 years, researchers will track thickness and blood vessel density to better understa…

This study asks whether pregnant women at high risk for preeclampsia understand the condition, its warning signs, and its risk factors. Researchers will interview 160 women at Sohag University Hospital using a standardized questionnaire. The goal is to identify gaps in knowledge …

This trial asks whether a one-week stay at sea level can lower blood pressure in the lungs of people with pulmonary arterial hypertension who live permanently above 2600 meters. Researchers will compare heart and lung measurements taken at high altitude with those taken after sev…

This study looks at what happens when people with pulmonary arterial hypertension, a condition that raises pressure in the lung's blood vessels, travel from their homes above 2600 meters down to sea level for a week, and then return. Researchers will measure heart rate variabilit…

This study tests whether AI-generated avatar videos and a chatbot can better engage older Veterans in cardiovascular clinical trials compared to standard mailed letters. Veterans aged 65 and older with heart conditions will receive either a routine invitation or a link to a websi…

Researchers are studying what happens when people with pulmonary arterial hypertension who live above 2600 meters spend a week at sea level. The trial compares their sleep, blood oxygen, and breathing during sleep at altitude and after seven days at sea level. It includes both pa…

Researchers are testing whether blood levels of a protein called asprosin are higher or lower in people with Behçet disease, and whether those levels match how active the disease is. The study will enroll 44 adults who meet the international criteria for Behçet disease. No treatm…

This study builds a registry of 400 women who have angina, or chest pain, even though their coronary arteries are not blocked. Doctors call this condition ANOCA, and it is more common in women than men, yet it has been under-studied. The registry will categorize different subtype…

This study tests whether ultrasound of the optic nerve sheath, a marker of brain pressure, can track brain swelling during ascending aortic surgery. Researchers will measure the optic nerve sheath diameter before, during, and after surgery in 134 adults undergoing this procedure.…

Doctors in the ICU often check blood gases through an arterial line, but that carries risks like clots and infection. This study asks whether blood drawn from a central venous line, which is already in place for other care, gives equally useful information. Researchers will compa…

This study looks at whether a specific heart ultrasound measurement, called left atrial reservoir strain, can better predict serious heart problems within 6 months after a non-ST-elevation heart attack (NSTEMI). Researchers will measure this strain in 150 patients and compare its…

Researchers are studying whether a quick head-turning test, called video head impulse testing, can detect subtle differences in inner ear balance function in people with vestibular migraine. The study compares 30 people with the condition to 30 healthy volunteers. Each participan…

This study gathers real-world data from medical records of patients with complex vascular anomalies treated with targeted therapies like mTOR inhibitors, MEK inhibitors, or PI3K inhibitors. Researchers will look at patient characteristics, treatment patterns, and side effects acr…

This study looks at whether a blood protein called asprosin is linked to metabolic syndrome and heart risk in people with rheumatoid arthritis. Researchers will compare asprosin levels in three groups: rheumatoid arthritis patients with metabolic syndrome, those without it, and h…

This trial tests whether eplerenone, a drug already approved for other conditions, lowers eye pressure in healthy adults. Researchers will compare eplerenone with a placebo in a crossover design, where each participant takes both treatments at different times. Eye pressure is mea…

This study looks at how ready people are to make lifestyle changes after having a heart attack treated with a stent. Researchers will ask participants who had a heart attack in the past six months to fill out questionnaires about their habits, quality of life, and emotional well-…

This study will test whether wearing a magnet helmet every day can change brain inflammation linked to migraines. Ten adults with migraines will use the helmet and have brain scans before and after the treatment period. Researchers will also track migraine symptoms through questi…

This study investigates whether the speed at which blood sugar falls after starting a new diabetes medicine affects small blood vessels in the eye. Adults with type 2 diabetes who are beginning a GLP-1 receptor agonist or an SGLT2 inhibitor will undergo advanced eye scans and blo…

Severe brain injuries can leave people in a coma or with limited awareness, and doctors struggle to predict who will recover. This study tests whether brain activity during sleep, measured with EEG, can forecast how quickly a patient wakes and how well they recover over a year. R…

This study observes how supply chain problems affect the availability of intracardiac echocardiography (ICE) catheters, which are used during certain heart procedures. Researchers will track real-world procurement attempts, including delays, cancellations, and substitutions, to s…

This study follows 75 older adults having elective heart surgery to understand why some recover quickly while others face complications like delirium or slow recovery. Researchers will measure frailty, physical and mental function, and a blood marker of biological stress called G…

This study follows 7,500 children aged 5 to 8 who live in areas where rheumatic heart disease is common. Each child gets a heart ultrasound once a year for three years to check for early signs of the disease. Researchers will count how many children develop rheumatic heart diseas…

This pilot study tests whether a low-load resistance exercise program for the lower legs can improve blood flow and oxygen use in the calf muscles of people with pulmonary arterial hypertension (PAH). Participants will do the exercises for 12 weeks, and researchers will measure o…

This study looks at how renal denervation, a minimally invasive procedure for hard-to-treat high blood pressure, affects kidney function shortly after and up to a year later. Researchers will measure kidney function and analyze blood and urine samples from 50 adults with resistan…

This observational study follows people with obesity-related heart failure to see how their heart performs during exercise, using stress echocardiography. It observes those who are taking GLP-1/GIP receptor agonists (like semaglutide or tirzepatide) as part of their routine care,…

This study explores whether ultrasound measurements of the eye can detect changes in brain pressure during laparoscopic gallbladder surgery. The surgery uses carbon dioxide gas to inflate the abdomen, which may affect pressure inside the skull. Researchers will compare two differ…

This study looks at anonymized health records from about 100,000 people in a Turkish hospital network to see how common cardiometabolic conditions—like obesity, type 2 diabetes, heart disease, fatty liver, and kidney disease—are and how often they occur together. By tracking thes…

This study investigates whether tiny particles called extracellular vesicles, released by brain cells into the blood, can serve as reliable markers of nerve damage in people with multiple sclerosis or stroke. Researchers will measure these particles in blood samples from 60 parti…

This study is a large international registry that will look back at the medical records of about 1,000 adults who were treated with the AngioVac system, a device that uses suction to remove blood clots, infected tissue, or other unwanted material from the heart and major blood ve…

This study aims to develop and validate a questionnaire called the ProChange scale, designed to measure the barriers and facilitators to lifestyle changes in people at risk for chronic diseases. The scale will be tested in adults aged 45 and older who receive prevention advice on…

This study is a large, real-world registry that will include over 10,000 people with coronary artery disease from more than 50 hospitals across China. The goal is to see how often a software tool called QFR, which analyzes angiogram images to guide treatment decisions, is used in…

This study aims to build a specialized AI model, called CorAI, for coronary artery disease (CAD). Researchers will collect de-identified medical data from about 640 patients with suspected or confirmed CAD to create a rich dataset. Using this data, they will develop and test CorA…

This study looks at stroke survivors who have mild aphasia—a condition causing language difficulties. Researchers want to see if these individuals also struggle with 'executive control' of language, which helps us manage and switch between words and ideas. By testing 30 participa…

This study is a large, observational registry in Türkiye that will track the real-world practice and outcomes of a procedure called percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) — a complete blockage of a coronary artery that has been present for at l…

This study investigates whether levels of a protein called neurofilament light chain (NFL) in the blood can predict neurological recovery in people who remain comatose after a cardiac arrest. Researchers will measure NFL at several time points over the first week in the ICU and c…

This study uses imaging scans to measure the size and blood flow speed in three key arteries—the carotid, renal, and femoral—in adults with high blood pressure. The goal is to see how hypertension affects these blood vessels, both structurally and functionally. By comparing measu…

This study tests whether a small implanted sensor, called CardioMEMS, can continuously track blood pressure in the lung arteries after surgery for chronic thromboembolic pulmonary hypertension (CTEPH). The surgery, called pulmonary endarterectomy, can cure CTEPH, but some patient…

This study looks at whether inflammation levels differ on either side of a blood clot in the brain during a stroke treatment called mechanical thrombectomy. Researchers will compare blood samples taken from before and after the clot to see if the difference is linked to how well …

This study explores whether ultrasound can reliably measure aneurysms in the descending thoracic aorta, the part of the main artery that runs through the chest. Researchers will compare ultrasound measurements with standard CT scans in about 60 adults, including some with known a…