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Heart Fat's tiny messengers: scientists probe particles that may drive cardiac risk

NCT ID NCT07817667

Knowledge-focused Sponsor: Assistance Publique Hopitaux De Marseille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers are studying tiny particles called extracellular vesicles that fat tissue around the heart releases, to understand how this fat may contribute to heart problems in people with obesity. The study enrolls 100 adults and children scheduled for open-heart surgery. During surgery, doctors take small samples of fat from around the heart and from under the chest skin. Scientists then compare the particles from both fat types and test how they affect inflammation and fat cell changes in the lab.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
biopsies of fat tissue around the heart and under the chest skin during heart surgery
What this could lead to
If researchers link specific particles from heart fat to inflammation, this could point toward new ways to spot or treat heart complications in people with obesity.
What could go wrong
This is an early observational study of 100 people having heart surgery, so it can show patterns but not prove cause or benefit. Biopsies add minor risk to an already major operation, and lab findings may not translate to patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Written informed consent obtained from the patient, parent(s), or legally authorized representative prior to participation. * Adult or pediatric patient. * Scheduled for open-heart cardiac surgery. * Affiliated with or beneficiary of a health insurance system. Exclusion Criteria: * Participation in another clinical research study requiring an exclusion period at the time informed consent is signed. * Individuals belonging to vulnerable populations covered by Articles L1121-5 to L1121-8 of the French Public Health Code, including adults under legal protection (guardianship or curatorship), individuals deprived of liberty, and pregnant or breastfeeding women. * Inability to understand the French language. * Contraindication to cardiac surgery, including uncontrolled sepsis or unstable hemodynamic status.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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More trials for these conditions

Other studies related to the condition(s) this trial covers.