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AI avatars could be the key to getting veterans into heart trials

NCT ID NCT07741955

Knowledge-focused Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Sep 04, 2026 · Updated 3 times

Summary

This study tests whether AI-generated avatar videos and a chatbot can better engage older Veterans in cardiovascular clinical trials compared to standard mailed letters. Veterans aged 65 and older with heart conditions will receive either a routine invitation or a link to a website where they can choose an avatar speaker and watch tailored videos about the trial. The goal is to see if this virtual approach increases the number of Veterans who actually enroll in a larger heart study.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
AI-generated avatar videos and chatbot for clinical trial outreach
What this could lead to
If effective, this approach could become a standard tool to improve diversity and enrollment in clinical trials, especially among older Veterans and others with limited health literacy.
What could go wrong
This is an early-stage behavioral study, and the impact on actual enrollment may be modest. The success depends on Veterans' comfort with and trust in AI avatars, which may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100,000 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Dec 2031

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion Criteria: \- Veteran receiving a mailed invitation to participate in the parent VA Cooperative Studies cardiovascular trial (therefore meeting inclusion criteria of the parent VA Cooperative Studies trial) Inclusion Criteria (Aim 1 Qualitative Interviews): * Veteran receiving care at VAPAHCS * Recently invited (within 3 months) to participate in an existing cardiovascular clinical trial at VAPAHCS * Able to provide informed consent in English Inclusion Criteria (Aim 1 Beta-Testing and Aim 3): * Veteran receiving care at VAPAHCS or a participating VA-CTC site * Able to view a brief video and complete a short survey in English Inclusion Criteria (Focus Groups): * VA study coordinator or trial investigator actively engaged in cardiovascular clinical trial recruitment at VAPAHCS or a VA-CTC site * Willing to participate in a 60-90 minute virtual focus group Exclusion Criteria: Exclusion Criteria: * Any exclusion criterion of the parent VA Cooperative Studies cardiovascular trial Exclusion Criteria (Aim 1 Qualitative Interviews): * Cognitive impairment documented in the electronic health record * Inability to communicate in English at a level sufficient for qualitative interview participation Exclusion Criteria (Aim 1 Beta-Testing and Aim 3): * Inability to communicate in English at a level sufficient for survey completion

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Conditions

The condition(s) this trial relates to.

atrial fibrillation cardiovascular disorder Patient Participation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrial fibrillation (AF) Cardiovascular diseases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • VA Palo Alto Health Care System, Palo Alto, CA

    Palo Alto, California, 94304-1207, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.