New combo therapy aims to rescue failing hearts without transplant
NCT ID NCT06965504
First seen Mar 15, 2026 · Last updated Jun 15, 2026 · Updated 13 times
Summary
This study tests whether using a heart pump (Impella 5.5) along with standard heart failure medications can help people with severe heart failure and shock recover without needing a heart transplant or permanent artificial heart. About 250 adults with weak hearts (ejection fraction 40% or less) will be enrolled. The goal is to see if this combined approach reduces death, hospital stays, and the need for heart replacement.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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Abbott Northwestern
Minneapolis, Minnesota, 555407, United States
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Atrium Health
Charlotte, North Carolina, 28204, United States
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Centennial Medical Center
Nashville, Tennessee, 32703, United States
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Duke University
Durham, North Carolina, 27710, United States
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Rutgers-Robert Wood Johnson Medical School
New Brunswick, New Jersey, 08901, United States
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Tampa General Hospital
Tampa, Florida, 33606, United States
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University of Pennsylvania Health System
Philadelphia, Pennsylvania, 19104, United States
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.