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Hong kong launches study to track heart shock survival

NCT ID NCT07323238

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Recruiting now
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Not yet recruiting This study
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By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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The trial has finished. Results may not be published yet.
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Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jun 27, 2026 · Last updated Sep 17, 2026 · Updated 2 times

Summary

This study will track 320 people in Hong Kong who have a heart attack complicated by cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will collect data on standard treatments, including the use of a heart pump called Impella, to see what works best. The goal is to improve survival and care for future patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 320 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Oct 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

HKCSI will approximately include 320 cases over 5 years. For subjects in GCSI-eligible cohort (expect n=80), data will be shared with GCSI Study Team and performed together with their Global Database. Analysis of the whole HKCSI cohort will be conducted locally. Study sites will screen all acute myocardial infarction complicated by cardiogenic shock patients, NSTEMI and STEMI, for participation in this trial.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of acute myocardial infarction (AMI) with the ECG and/or biomarker evidence of S-T elevation myocardial infarction (STEMI) or non -S-T elevation myocardial infarction (NSTEMI) * Cardiogenic Shock is defined as presence of at least two of the following 1. Hypotension (systolic blood pressure ≤ 100 mmHg, or inotropes/vasopressors to maintain systolic blood pressure ≥ 100 mmHg) 2. Evidence of end organ perfusion: elevated serum lactate levels (venous or arterial), cool extremities, oliguria/anuria 3. Hemodynamic criteria represented by cardiac index of \<2.2 L/min/m² or a cardiac ≤ 0.6 watts * Patient is supported with a transvalvular MCS as the initial device (criteria for GCSI-eligible Cohort) * Patients undergo PCI within 12 hours of hospital presentation (criteria for GCSI-eligible Cohort) * Subject or legally designated representative (LDR) has provided written informed consent. For patients not able to provide consent, data collection will be conducted in retrospective manner with study consent waived. Exclusion Criteria: * Unwitnessed out of hospital cardiac arrest or any cardiac arrest in which return of spontaneous circulation (ROSC) is not achieved within 20 minutes * Patients demonstrate any signs of anoxic brain injury prior to the INDEX PCI (signs of anoxic injury include, posturing, seizures). * IABP placed prior to MCS (criteria for GCSI-eligible Cohort) * Septic, anaphylactic, hemorrhagic, and neurologic causes of shock * Non-ischemic causes of shock/hypotension (pulmonary embolism, pneumothorax, myocarditis, tamponade, etc.) * Active bleeding for which MCS in contraindicated * Recent major surgery for which MCS is contraindicated * Mechanical complication of AMI (acute ventricular septal defect (VSD) or acute papillary muscle rupture) * Known left ventricular thrombus for which MCS in contraindicated (criteria for GCSI-eligible Cohort) * Mechanical aortic prosthetic valve (criteria for GCSI-eligible Cohort) * Contraindication to intravenous systemic anticoagulation which precludes placement of MCS. Patients who fulfills all Eligibility Criteria would be recruited and considered GSCI-eligible. AMI-CS patients that did not use MCS, ie. Not fulfiliing both Inclusion Criteria 3, 4, would not be considered screen failure and would still be screened and recruited into HKCSI GCSI-ineligible cohort. Likewise, patients who meet any of Exclusion Criteria will not be GCSI-eligible. Specifically, patients who met exclusion criteria 3, 9, 10 only will be recruited into GCSI-ineligible cohort.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Prince of Wales Hospital

    Hong Kong, Shatin, 0000, Hong Kong

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Other studies related to the condition(s) this trial covers.