Heart valve leaks after myectomy may resolve without extra surgery
NCT ID NCT07831811
First seen Sep 21, 2026 · Last updated Sep 21, 2026
Summary
Researchers at University Health Network in Toronto are reviewing the records of 150 adults who had septal myectomy for hypertrophic obstructive cardiomyopathy. They compare intraoperative echocardiograms with predischarge echocardiograms to see how often moderate or worse mitral regurgitation improves to mild or less. The study asks whether some postoperative mitral regurgitation is temporary and linked to posterior leaflet restriction rather than a structural valve problem. The goal is to inform whether a conservative approach to mitral valve intervention is reasonable.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If the pattern holds, doctors could avoid extra mitral valve surgery in some patients and rely on echocardiography to guide a wait-and-see approach.
- What could go wrong
- This is a small, single-center review of past records, so its findings may not apply to other hospitals or patients. It cannot prove cause and effect, and image quality limits what can be measured.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 150 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
We will be enrolling all patients who are ≥18 years and underwent Septal Myectomy surgery between January 1, 2022 and December 31, 2025
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients (≥18 years) * Undergoing septal myectomy for HOCM * Availability of intraoperative post-cardiopulmonary bypass TEE images * Availability of predischarge TTE Exclusion Criteria: * Concomitant primary mitral valve disease due to structural abnormalities, prior ischemic MR or previous MV intervention (repair or replacement) * Inadequate echocardiographic image quality precluding MR assessment * Patients without paired TEE and TTE studies
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
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How to take part
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The official record
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A doctor treating you
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